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Victoria Hemming, Adam D Jakes, Geoff Shenton, Bob Phillips
BACKGROUND: Febrile neutropenia (FNP) causes significant morbidity and mortality in children undergoing treatment for cancer. The development of clinical decision rules to help stratify risks in paediatric FNP patients and the use of inflammatory biomarkers to identify high risk patients is an area of recent research. This study aimed to assess if procalcitonin (PCT) levels could be used to help diagnose or exclude severe infection in children with cancer who present with febrile neutropenia, both as a single measurement and in addition to previously developed clinical decision rules...
January 5, 2017: BMC Pediatrics
Hiroki Suzuki, Shun Hamao, Yoshiki Seto, Hideyuki Sato, Jennifer Wong, Robert K Prud'homme, Hak-Kim Chan, Satomi Onoue
We present a combined nanoparticle (NP) formation process and spray drying to create a nano-matrix formulation of cyclosporine A (CsA) and mannitol (nCsA/MAN) to increase the bioavailability of CsA. CsA NPs were prepared by flash nano precipitation (FNP) using a multi-inlet vortex mixer, and spray-dried with or without mannitol to prepare nCsA/MAN or nanoprecipitated CsA powder (nCsA), respectively. Pre-forming the NPs by FNP uncouples the sizes of the CsA inclusions from the ultimate micron-sized powders produced by spray drying...
January 10, 2017: International Journal of Pharmaceutics
Milan Borišev, Ivana Borišev, Milan Župunski, Danijela Arsenov, Slobodanka Pajević, Živko Ćurčić, Jovica Vasin, Aleksandar Djordjevic
Over the past few years, significant efforts have been made to decrease the effects of drought stress on plant productivity and quality. We propose that fullerenol nanoparticles (FNPs, molecular formula C60(OH)24) may help alleviate drought stress by serving as an additional intercellular water supply. Specifically, FNPs are able to penetrate plant leaf and root tissues, where they bind water in various cell compartments. This hydroscopic activity suggests that FNPs could be beneficial in plants. The aim of the present study was to analyse the influence of FNPs on sugar beet plants exposed to drought stress...
2016: PloS One
Mariana Seke, Danijela Petrovic, Aleksandar Djordjevic, Danica Jovic, Milica Labudovic Borovic, Zdenko Kanacki, Milan Jankovic
Fullerenol (C60(OH)24) is present in aqueous solutions in the form of polyanion nanoparticles with particles' size distribution within the range from 15 to 42 nm. In this research it is assumed that these features could enable fullerenol nanoparticles (FNPs) to bind positively charged molecules like doxorubicin (DOX) and serve as drug carriers. Considering this, fullerenol/doxorubicin nanocomposite (FNP/DOX) is formed and characterized by ultra-performance liquid chromatography tandem mass spectrometry, dynamic light scattering, atomic force microscopy and transmission electron microscopy...
December 2, 2016: Nanotechnology
Nikolas T Weissmueller, Hoang D Lu, Amanda Hurley, Robert K Prud'homme
One factor limiting the expansion of nanomedicines has been the high cost of the materials and processes required for their production. We present a continuous, scalable, low cost nanoencapsulation process, Flash Nanoprecipitation (FNP) that enables the production of nanocarriers (NCs) with a narrow size distribution using zein corn proteins. Zein is a low cost, GRAS protein (having the FDA status of "Generally Regarded as Safe") currently used in food applications, which acts as an effective encapsulant for hydrophobic compounds using FNP...
November 14, 2016: Biomacromolecules
Sue Channon, Marie-Jet Bekkers, Julia Sanders, Rebecca Cannings-John, Laura Robertson, Kristina Bennert, Christopher Butler, Kerenza Hood, Michael Robling
BACKGROUND: Motivational Interviewing (MI) is a person-centred counselling approach to behaviour change which is increasingly being used in public health settings, either as a stand-alone approach or in combination with other structured programmes of health promotion. One example of this is the Family Nurse Partnership (FNP) a licensed, preventative programme for first time mothers under the age of 20, delivered by specialist family nurses who are additionally trained in MI. The Building Blocks trial was an individually randomised controlled trial comparing effectiveness of Family Nurse Partnership when added to usual care compared to usual care alone within 18 sites in England...
2016: BMC Nursing
Amit Wolfovitz, Noam Yehudai, Michal Luntz
OBJECTIVES/HYPOTHESIS: To identify and analyze factors influencing the outcome of facial nerve palsy (FNP) in a pediatric population. STUDY DESIGN: Retrospective study. METHODS: Sixty-seven pediatric patients (72 consecutive cases) diagnosed with and treated for FNP were divided into two severity subgroups. Associations between recovery in these groups and categorical variables were assessed using the Fisher exact test and for age using the t test...
September 19, 2016: Laryngoscope
Prabhat Kumar, Riyaz Charaniya, Anish Bahl, Anindya Ghosh, Juhi Dixit
Facial nerve palsy (FNP) is a common medical problem and can be unilateral or bilateral. Unilateral facial palsy has an incidence of 25 per 100,000 population and most of them are idiopathic. However, facial diplegia or bilateral facial nerve palsy (B-FNP) is rare with an incidence of just 1 per 5,000,000 population and only 20 percent cases are idiopathic. Facial diplegia is said to be simultaneous if the other side is affected within 30 days of involvement of first side. Guillain-Barre Syndrome (GBS) is a common cause of facial diplegia and almost half of these patients have facial nerve involvement during their illness...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Wacław Kopala, Andrzej Kukwa
INTRODUCTION: The stapedius nerve is one of the branches of the facial nerve in the temporal bone. It supplies the stapedius muscle, which is responsible for the attenuation reflex that protects the inner ear from loud noises. The stapedius (acoustic) reflex (SR) test is useful in identifying the site of facial nerve injury. The return of the SR (acoustic) to normal after an injury is a good prognostic factor in the treatment of facial nerve palsy. OBJECTIVE: The aim of this study was to evaluate the effect of FNP on the SR (acoustic) response and determine the acoustic reflex threshold (ART) levels on the affected side...
October 2016: International Journal of Pediatric Otorhinolaryngology
Elaine Webber, Mary Serowoky
INTRODUCTION: Health care provider support is essential for breastfeeding success. Family Nurse Practitioners (FNP) are in a unique position to promote and manage breastfeeding. There is a gap in the literature regarding the amount and type of breastfeeding curricular content in FNP programs. METHOD: An online survey of FNP programs was conducted. Data collection included program descriptors, didactic breastfeeding coursework, and clinical breastfeeding opportunities available to students...
August 20, 2016: Journal of Pediatric Health Care
Angela Phillips
Nephrology nurses play a major role in every aspect of caring for patients on dialysis. It is always challenging to witness patients and families struggling through dialysis modality changes coupled with end-of-life decisions. Open discussions and care provided by an interdisciplinary team approach provides the foundational structure for quality care necessary for this population. In the case of Mr. T., a dialysis modality change was a necessary change in his life. The FNP PCP played a significant role in coordinating his care to achieve the desired outcomes and ensure there was a coordinated team approach...
May 2016: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
Ramona Ann Parker, Linda D Hook, Mary Elaine Jones
BACKGROUND AND PURPOSE: Care coordination and specialized knowledge of prescriptive authority are fundamental to advanced nursing practice. Little research documents patient clinical outcomes in primary care when nurse practitioners are members of an interprofessional education and collaborative practice (IPECP) team. This cross-sectional study examined differences in glycemic control among Texas patients who received care by a Family Nurse Practitioner (FNP) and an IPECP team in one calendar year...
December 2016: Journal of the American Association of Nurse Practitioners
Margarida Ferreira, João Firmino-Machado, Elisa A Marques, Paula C Santos, Ana Daniela Simões, José A Duarte
OBJECTIVE: The main aim of this study was to identify the prognostic factors that contribute to complete recovery at 6 weeks and 6 months in patients with Bell's palsy. MATERIAL AND METHODS: This is a prospective, longitudinal, and descriptive study that included 123 patients diagnosed with facial nerve palsy (FNP) at a hospital in Guimarães, Portugal. However, only 73 patients with Bell's palsy (BP) were included in the assessment of recovery at 6 weeks and 6 months...
October 2016: Neurological Research
Ranganayaki Muralidharan, Anish Babu, Narsireddy Amreddy, Kanthesh Basalingappa, Meghna Mehta, Allshine Chen, Yan Daniel Zhao, Uday B Kompella, Anupama Munshi, Rajagopal Ramesh
BACKGROUND: Human antigen R (HuR) is an RNA binding protein that is overexpressed in many human cancers, including lung cancer, and has been shown to regulate the expression of several oncoproteins. Further, HuR overexpression in cancer cells has been associated with poor-prognosis and therapy resistance. Therefore, we hypothesized that targeted inhibition of HuR in cancer cells should suppress several HuR-regulated oncoproteins resulting in an effective anticancer efficacy. To test our hypothesis, in the present study we investigated the efficacy of folate receptor-α (FRA)-targeted DOTAP:Cholesterol lipid nanoparticles carrying HuR siRNA (HuR-FNP) against human lung cancer cells...
June 21, 2016: Journal of Nanobiotechnology
Takahiro Kanno, Shintaro Sukegawa, Hiroto Tatsumi, Masaaki Karino, Yoshiki Nariai, Eiji Nakatani, Yoshihiko Furuki, Joji Sekine
PURPOSE: The retromandibular transparotid approach (RMA) to condylar fractures of the mandible provides excellent access, but can increase the risk of complications. The aim of this study was to estimate the frequency of facial nerve paralysis (FNP) and associated postoperative complications after open reduction and rigid internal fixation (ORIF) of subcondylar fractures through the RMA. MATERIALS AND METHODS: This was a retrospective cohort study of patients with condylar fractures requiring ORIF through the RMA...
October 2016: Journal of Oral and Maxillofacial Surgery
Kunal R Sinha, Daniel B Rootman, Babak Azizzadeh, Robert A Goldberg
IMPORTANCE: Understanding the prevalence and clinical features of eyelid malpositions in facial nerve palsy (FNP) may inform proper management of patients with FNP and supplement our knowledge of eyelid physiology. OBJECTIVE: To describe eyelid malposition in FNP. DESIGN, SETTING, AND PARTICIPANTS: In this retrospective cohort study, patients with FNP seen at the Center for Advanced Facial Plastic Surgery and Jules Stein Eye Institute between January 1, 1999, and June 1, 2014, were reviewed for study inclusion...
September 1, 2016: JAMA Facial Plastic Surgery
Preeti Patil-Chhablani, Sowmya Murthy, Meenakshi Swaminathan
BACKGROUND: Facial nerve palsy (FNP) occurs less frequently in children as compared to adults but most cases are secondary to an identifiable cause. These children may have a variety of ocular and systemic features associated with the palsy and need detailed ophthalmic and systemic evaluation. METHODS: This was a retrospective chart review of all the cases of FNP below the age of 16 years, presenting to a tertiary ophthalmic hospital over the period of 9 years, from January 2000 to December 2008...
December 2015: Eye Science
Yuan Qian, Honglin Jin, Sha Qiao, Yanfeng Dai, Chuan Huang, Lisen Lu, Qingming Luo, Zhihong Zhang
The design of peptide-based subunit vaccine formulations for the direct delivery of tumor antigen peptides (Aps) to dendritic cells (DCs) localized within draining lymph nodes (DLNs) is challenging. Mature DCs (mDCs) are abundantly distributed within DLNs but have dramatically reduced endocytic uptake and antigen-processing abilities, so their role as potential vaccine targets has been largely overlooked. Here we report an ultra-small biocompatible nanovaccine (α-Ap-FNP) functionalized by avidly targeting delivery of Ap via the scavenger receptor class B1 (SR-B1) pathway to mDCs...
May 5, 2016: Biomaterials
Hoang D Lu, Brian K Wilson, Andrew Heinmiller, Bill Faenza, Shahram Hejazi, Robert K Prud'homme
Photoacoustic (PA) imaging is an emerging hybrid optical-ultrasound based imaging technique that can be used to visualize optical absorbers in deep tissue. Free organic dyes can be used as PA contrast agents to concurrently provide additional physiological and molecular information during imaging, but their use in vivo is generally limited by rapid renal clearance for soluble dyes and by the difficulty of delivery for hydrophobic dyes. We here report the use of the block copolymer directed self-assembly process, Flash NanoPrecipitation (FNP), to form series of highly hydrophobic optical dyes into stable, biocompatible, and water-dispersible nanoparticles (NPs) with sizes from 38 to 88 nm and with polyethylene glycol (PEG) surface coatings suitable for in vivo use...
June 15, 2016: ACS Applied Materials & Interfaces
Lindsayws Andrews
First-time teenage mothers and their babies are likely to have increased levels of need. This article explores how supervision supports Family Nurse Partnership (FNP) nurses to undertake complex work with teenage, first-time mothers and their babies. Careful application of a supervision model can provide the structure for a safe, containing, reflective space.
January 27, 2016: Nursing Times
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