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https://www.readbyqxmd.com/read/28929769/design-and-solidification-of-fast-releasing-clofazimine-nanoparticles-for-treatment-of-cryptosporidiosis
#1
Yingyue Zhang, Jie Feng, Simon A McManus, Hoang D Lu, Kurt D Ristroph, Eugene J Cho, Ellen L Dobrijevic, Hak-Kim Chan, Robert K Prud'homme
Clofazimine, a lipophilic (log P = 7.66) riminophenazine antibiotic approved by the US Food and Drug Administration (FDA) with a good safety record, was recently identified as a lead hit for cryptosporidiosis through a high-throughput phenotypic screen. Cryptosporidiosis requires fast-acting treatment as it leads to severe symptoms which, if untreated, result in morbidity for infants and small children. Consequently, a fast-releasing oral formulation of clofazimine in a water-dispersible form for pediatric administration is highly desirable...
September 20, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28925107/formulation-of-long-wavelength-indocyanine-green-nanocarriers
#2
Vikram J Pansare, William J Faenza, Hoang Lu, Douglas H Adamson, Robert K Prud'homme
Indocyanine green (ICG), a Food and Drug Administration (FDA)-approved fluorophore with excitation and emission wavelengths inside the "optical imaging window," has been incorporated into nanocarriers (NCs) to achieve enhanced circulation time, targeting, and real-time tracking in vivo. While previous studies transferred ICG exogenously into NCs, here, a one-step rapid precipitation process [flash nanoprecipitation (FNP)] creates ICG-loaded NCs with tunable, narrow size distributions from 30 to 180 nm. A hydrophobic ion pair of ICG-tetraoctylammonium or tetradodecylammonium chloride is formed either in situ during FNP or preformed then introduced into the FNP feed stream...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28862257/outcomes-of-lower-eyelid-retractor-recession-and-lateral-horn-lysis-in-lower-eyelid-elevation-for-facial-nerve-palsy
#3
P Tan, J Wong, W F Siah, R Malhotra
PurposeTo report outcomes and complications of lower eyelid retractor recession and lateral horn lysis (RR) for lower eyelid elevation in patients with facial nerve palsy (FNP).Patients and methodsRetrospective review. Patients with FNP undergoing RR alone (group 1) or with adjunctive procedures (canthal suspension-group 2, tarsorrhaphy-group 3, and full-thickness skin graft-group 4) during a 5-year period were included. Patient demographics, lagophthalmos, occurrence of eyelid malpositions, recurrent retraction, and repeat procedures were noted from medical records...
September 1, 2017: Eye
https://www.readbyqxmd.com/read/28799197/cost-effectiveness-of-the-family-nurse-partnership-fnp-programme-in-england-evidence-from-the-building-blocks-trial
#4
Belen Corbacho, Kerry Bell, Eugena Stamuli, Gerry Richardson, Sarah Ronaldson, Kerenza Hood, Julia Sanders, Michael Robling, David Torgerson
RATIONAL, AIMS, AND OBJECTIVES: The Family Nurse Partnership (FNP) is a licensed intensive home visiting intervention developed in the United States. It has been provided in England by the Department of Health since 2006. The Building Blocks trial assessed the effectiveness and cost-effectiveness of FNP in England. METHODS: We performed a cost-utility analysis (National Health Service (NHS) perspective) alongside the Building Blocks trial (over 2.5 y). The analysis was conducted in accordance with National Institute for Health and Clinical Excellence (NICE) reference case standards...
August 11, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28742546/flipping-the-objective-structured-clinical-examination-a-teaching-innovation-in-graduate-nursing-education
#5
Cristi Day, Connie Barker, Eva Bell, Elizabeth Sefcik, Deborah Flournoy
Objective evaluation of distance-based family nurse practitioner (FNP) students can be challenging. One FNP program piloted a teaching innovation, the video-enhanced objective structured clinical examination (VE-OSCE) or "flip" of the traditional face-to-face OSCE, to assess student clinical performance in a controlled online environment using a teleconferencing platform. This project sought to assess the VE-OSCE design, implementation, and ability to identify FNP student learning needs.
July 24, 2017: Nurse Educator
https://www.readbyqxmd.com/read/28736263/facile-assembly-and-loading-of-theranostic-polymersomes-via-multi-impingement-flash-nanoprecipitation
#6
Sean Allen, Omar Osorio, Yu-Gang Liu, Evan Scott
Flash nanoprecipitation (FNP) has proven to be a powerful tool for the rapid and scalable assembly of solid-core nanoparticles from block copolymers. The process can be performed using a simple confined impingement jets mixer and provides an efficient and reproducible method of loading micelles with hydrophobic drugs. To date, FNP has not been applied for the fabrication of complex or vesicular nanoarchitectures capable of encapsulating hydrophilic molecules or bioactive protein therapeutics. Here, we present FNP as a single customizable method for the assembly of bicontinuous nanospheres, filomicelles and vesicular, multilamellar and tubular polymersomes from poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers...
September 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28714227/transepithelial-transport-of-milk-derived-angiotensin-i-converting-enzyme-inhibitory-peptide-with-the-rlsfnp-sequence
#7
Yuxing Guo, Junai Gan, Qian Zhu, Xiaoqun Zeng, Yangying Sun, Zhen Wu, Daodong Pan
BACKGROUND: To exert an antihypertensive effect after oral administration, Angiotensin I-converting enzyme (ACE) inhibitory peptides must remain active after intestinal transport. The purpose of this article is to elucidate the transport permeability and route of ACE inhibitory peptide Arg-Leu-Ser-Phe-Asn-Pro (RLSFNP) across the intestinal epithelium using a Caco-2 cell monolayers. RESULTS: Intact RLSFNP and RLSFNP breakdown fragments F, FNP, SFNP and RLSF were found in RLSFNP transport solution across Caco-2 cell monolayers using ultra-performance liquid chromatography tandem mass (UPLC-MS)...
July 17, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28560625/fullerol-c60-oh-24-nanoparticles-and-mycotoxigenic-fungi-a-preliminary-investigation-into-modulation-of-mycotoxin-production
#8
Tihomir Kovač, Bojan Šarkanj, Tomislav Klapec, Ivana Borišev, Marija Kovač, Ante Nevistić, Ivica Strelec
Increased use of fullerols in various fields and expected increase of their environmental spread impose the necessity for testing fullerol nanoparticles (FNP) effects on microbiota. There is little information available on the interaction of mycotoxigenic fungi and FNP, despite FNP having a great potential of modifying mycotoxin production. Namely, FNP exhibit both ROS-quenching and ROS-producing properties, while oxidative stress stimulates mycotoxin synthesis in the fungi. In order to shed some light on the extent of interaction between FNP and mycotoxigenic fungi, the effects of fullerol C60(OH)24 nanoparticles (10, 100, 1000 ng/mL) on mycelial growth, aflatoxin production and oxidative stress modulation in an aflatoxigenic strain of Aspergillus flavus (NRRL 3251) during 168 h of incubation in a liquid culture medium were examined...
July 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28556268/incidence-of-non-amyloidogenic-mutations-in-the-transthyretin-gene-in-patients-with-autonomic-and-small-fiber-neuropathy
#9
Todd D Levine, Ruth J Bland Fnp
Introduction Mutations of the transthyretin (TTR) gene have been associated with polyneuropathy; the protein product has a tendency to form amyloid deposits in the peripheral nervous system. METHODS: Patients with small fiber neuropathy (SFN) with or without autonomic symptoms were given skin biopsies to assess nerve fiber density. Any patient with autonomic symptoms was assessed for autonomic neuropathy (AN). If testing revealed no clear cause of neuropathy, the TTR gene was sequenced...
May 26, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28555605/surgical-treatment-for-epstein-barr-virus-otomastoiditis-complicated-by-facial-nerve-paralysis-a-case-report-of-two-young-brothers-and-review-of-literature
#10
REVIEW
Evelien van Eeten, Hubert Faber, Dirk Kunst
We report the case of two young brothers with Epstein-Barr virus (EBV) otomastoiditis complicated by a facial nerve paralysis. The boys, aged 7 months (patient A) and 2 years and 8 months (patient B), were diagnosed with a facial nerve paralysis House-Brackmann (HB) grade IV (A) and V (B). After unsuccessful pharmacological treatment, patient A underwent mastoidectomy and atticoantrotomy and patient B underwent a transmastoidal surgical decompression of the facial nerve. They recovered to HB grades I and II facial nerve palsy (FNP), respectively...
April 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28468702/bridging-the-policy-clinical-practice-divide-a-conversation-with-parmeeth-m-s-atwal-jd-msn-rn-mph-fnp
#11
Marie Manthey
Marie Manthey, founder of Creative Health Care Management, interviews Parmeeth "Par" Atwal, whose first career included representing the National Association of Community Health Centers as an attorney, editor of a major health policy journal, and a senior position in the Office of the National Coordinator for Health Information Technology at the U.S. Department of Health and Human Services. He then became an active participant in the health care system, earning a bachelor of science in nursing, working in cardiac critical care, and now becoming a family nurse practitioner...
May 1, 2017: Creative Nursing
https://www.readbyqxmd.com/read/28467139/campus-health-centers-lack-of-information-regarding-providers-a-content-analysis-of-division-i-campus-health-centers-provider-websites
#12
Evan K Perrault
Campus health centers are a convenient, and usually affordable, location for college students to obtain health care. Staffed by licensed and trained professionals, these providers can generally offer similar levels of care that providers at off-campus clinics can deliver. Yet, previous research finds students may forgo this convenient, on-campus option partially because of a lack of knowledge regarding the quality of providers at these campus clinics. This study sought to examine where this information deficit may come from by analyzing campus health centers' online provider information...
May 3, 2017: Health Communication
https://www.readbyqxmd.com/read/28457546/comparison-of-4-label-based-immunochromatographic-assays-for-the-detection-of-escherichia-coli-o157-h7-in-milk
#13
Kai Luo, Liming Hu, Qi Guo, Chenghui Wu, Songsong Wu, Daofeng Liu, Yonghua Xiong, Weihua Lai
Immunochromatographic assays (ICA) are widely used to detect pathogens. In this study, we used traditional gold nanoparticles (GNP), quantum dots (QD), fluorescent nanoparticles (FNP), and europium (Eu) (III) chelate nanoparticles (EuNP) as ICA labels. We first compared the ability of the 4 ICA test strips to quantitatively detect Escherichia coli O157:H7 in milk. We then optimized various parameters influencing the ICA. The sensitivity to E. coli O157:H7 of the GNP-ICA, QD-ICA, FNP-ICA, and EuNP-ICA was 2...
July 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28402738/ferrule-effect-dominates-over-use-of-a-fiber-post-when-restoring-endodontically-treated-incisors-an-in-vitro-study
#14
P Magne, P C Lazari, M A Carvalho, T Johnson, A A Del Bel Cury
OBJECTIVES:  The aim of this study was to investigate the restoration of broken-down endodontically treated incisors with the ferrule effect using glass ceramic crowns bonded to composite resin core buildups with or without a fiber post. A no-ferrule group with post was also included for comparison. METHODS AND MATERIALS:  Thirty decoronated endodontically treated bovine incisors with a 2-mm ferrule were restored with a direct buildup using a nanohybrid direct composite resin (Miris 2 and Optibond FL) with or without a glass-fiber-reinforced post...
July 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28319397/scalable-platform-for-structured-and-hybrid-soft-nanocolloids-by-continuous-precipitation-in-a-confined-environment
#15
Victoria E Lee, Chris Sosa, Rui Liu, Robert K Prud'homme, Rodney D Priestley
Geometrically structured polymer nanocolloids, including Janus nanocolloids, have been widely investigated for their unique properties, which are derived from their anisotropy. Controlled surface decoration with inorganic nanoparticles could induce another level of functionality into structured nanocolloids that could enable applications in fields ranging from rewriteable electronics to biphasic catalysis. Here, we demonstrate flash nanoprecipitation (FNP) as a one-step, scalable process platform for manufacturing hybrid polymer-inorganic nanocolloids in which one phase is selectively decorated with a metal nanocatalyst by tuning the molecular interactions between the feed ingredients during the process...
March 29, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28315688/fullerenol-nanoparticles-prevents-doxorubicin-induced-acute-hepatotoxicity-in-rats
#16
Vesna Jacevic, Aleksandar Djordjevic, Branislava Srdjenovic, Vukosava Milic-Tores, Zoran Segrt, Viktorija Dragojevic-Simic, Kamil Kuca
Doxorubicin (DOX), commonly used antineoplastic agent, affects bone marrow, intestinal tract and heart, but it also has some hepatotoxic effects. Main mechanism of its toxicity is the production of free reactive oxygen species. Polyhidroxilated C60 fullerene derivatives, fullerenol nanoparticles (FNP), act as free radical scavengers in in vitro systems. The aim of the study was to investigate potential FNP protective role against DOX-induced hepatotoxicity in rats. Experiments were performed on adult male Wistar rats...
April 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28213909/improving-prescribing-practices-a-pharmacist-led-educational-intervention-for-nurse-practitioner-students
#17
Jennifer A Sabatino, Maria C Pruchnicki, Alexa M Sevin, Elizabeth Barker, Christopher G Green, Kyle Porter
BACKGROUND AND PURPOSE: To assess impact of a pharmacist-led educational intervention on family nurse practitioner (FNP) students' prescribing skills, perception of preparedness to prescribe, and perception of pharmacist as collaborator. METHOD: Prospective pre-post assessment of a 14-week educational intervention in an FNP program in the spring semester of 2014. Students participated in an online module of weekly patient cases and prescriptions emphasizing legal requirements, prescription accuracy, and appropriate therapy...
May 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28209378/facial-nerve-paralysis-after-super-selective-intra-arterial-chemotherapy-for-oral-cancer
#18
S Sugiyama, T Iwai, S Oguri, T Koizumi, K Mitsudo, I Tohnai
Facial nerve paralysis (FNP) after super-selective intra-arterial chemotherapy (SSIAC) is a relatively rare local side effect of SSIAC to the maxillary artery (MA) or the middle meningeal artery (MMA). The incidence and prognosis of FNP after SSIAC in 381 patients with oral cancer (133 with catheterization of the MA, 248 without) was investigated retrospectively. Only three patients (two male and one female) had FNP, for an incidence of 0.8%. All patients with FNP had undergone catheterization of the MA, and the incidence of FNP in this group was 2...
February 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28161243/facial-nerve-paralysis-associated-with-temporal-bone-masses
#19
Hironobu Nishijima, Kenji Kondo, Ryoji Kagoya, Hitoshi Iwamura, Kazuo Yasuhara, Tatsuya Yamasoba
OBJECTIVE: To investigate the clinical and electrophysiological features of facial nerve paralysis (FNP) due to benign temporal bone masses (TBMs) and elucidate its differences as compared with Bell's palsy. METHODS: FNP assessed by the House-Brackmann (HB) grading system and by electroneurography (ENoG) were compared retrospectively. RESULTS: We reviewed 914 patient records and identified 31 patients with FNP due to benign TBMs. Moderate FNP (HB Grades II-IV) was dominant for facial nerve schwannoma (FNS) (n=15), whereas severe FNP (Grades V and VI) was dominant for cholesteatomas (n=8) and hemangiomas (n=3)...
February 1, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28141956/bell-s-facial-nerve-palsy-in-pregnancy-a-clinical-review
#20
Ahsen Hussain, Charles Nduka, Philippa Moth, Raman Malhotra
Bell's facial nerve palsy (FNP) during pregnancy and the puerperium can present significant challenges for the patient and clinician. Presentation and prognosis can be worse in this group of patients. This article reviews the background, manifestation and management options of FNP. In particular, it focuses on the controversies that exist regarding corticosteroid use during pregnancy and outlines approaches to diagnosis and treatment. Based on this review, we recommend an early evidence-based approach using guidelines derived from non-pregnant populations...
May 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
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