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eosinophilic bronchiolitis

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https://www.readbyqxmd.com/read/30253848/pathological-lesions-in-the-lungs-of-red-deer-cervus-elaphus-l-induced-by-a-newly-described-dictyocaulus-cervi-nematoda-trichostrongyloidea
#1
Anna M Pyziel, Izabella Dolka, Joanna Werszko, Zdzisław Laskowski, Żaneta Steiner-Bogdaszewska, Jan Wiśniewski, Aleksander W Demiaszkiewicz, Krzysztof Anusz
The large lungworms of the genus Dictyocaulus are causative agents of parasitic bronchitis in various ungulate hosts, including red deer. Recently, the red deer-derived lungworm D. cervi was described and separated from D. eckerti. Little is known of the transmission patterns, epidemiology, geographical distribution and pathogenicity of D. cervi. Histological examinations were performed on 22 formalin-fixed lung tissue samples of hunted red deer. Exclusively, D. cervi adults were derived from 15 red deer and confirmed molecularly (GenBank accession: MH183394)...
September 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/30240701/severe-bronchiolitis-profiles-and-risk-of-developing-recurrent-wheezing-by-age-3-years
#2
Orianne Dumas, Kohei Hasegawa, Jonathan M Mansbach, Ashley F Sullivan, Pedro A Piedra, Carlos A Camargo
BACKGROUND: A better understanding of bronchiolitis heterogeneity may help clarify its relationship with the development of recurrent wheezing and asthma. OBJECTIVES: To identify severe bronchiolitis profiles by a clustering approach, and to investigate for the first time their association with allergy/inflammatory biomarkers; nasopharyngeal microbiota; and development of recurrent wheezing by age 3 years. METHODS: We analyzed data from a prospective, 17-center U...
September 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30184280/monocytes-accumulate-in-the-airways-of-children-with-fatal-asthma
#3
Ibon Eguíluz-Gracia, Kristiina Malmstrom, Sinan Ahmed Dheyauldeen, Jouko Lohi, Antti Sajantila, Ragnhild Aaløkken, Arvind Y M Sundaram, Gregor D Gilfillan, Mika Makela, Espen S Baekkevold, Frode L Jahnsen
BACKGROUND: Activated T-helper type 2 (Th2) cells are believed to play a pivotal role in allergic airway inflammation, but which cells attract and activate Th2 cells locally has not been fully determined. Recently, it was shown in an experimental human model of allergic rhinitis (AR) that activated monocytes rapidly accumulate in the nasal mucosa after local allergen challenge, where they promote recruitment of Th2 cells and eosinophils. OBJECTIVE: To investigate whether monocytes are recruited to the lungs in paediatric asthma...
September 5, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29929509/parasitic-pneumonia-in-roe-deer-capreolus-capreolus-in-cornwall-great-britain-caused-by-varestrongylus-capreoli-protostrongylidae
#4
Victor R Simpson, Damer P Blake
BACKGROUND: Roe deer (Capreolus capreolus) became extinct over large areas of Britain during the post mediaeval period but following re-introductions from Europe during the 1800s and early 1900s the population started to recover and in recent decades there has been a spectacular increase. Many roe deer are shot in Britain each year but despite this there is little published information on the diseases and causes of mortality of roe deer in Great Britain. CASE PRESENTATION: The lungs of two hunter-shot roe deer in Cornwall showed multiple, raised, nodular lesions associated with numerous protostrongylid-type nematode eggs and first stage larvae...
June 22, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29707330/aberrant-epithelial-remodeling-with-impairment-of-cilia-architecture-in-non-cystic-fibrosis-bronchiectasis
#5
Zhuang-Gui Chen, Ying-Ying Li, Zhao-Ni Wang, Ming Li, Hui-Fang Lim, Yu-Qi Zhou, Liang-Ming Cai, Ya-Ting Li, Li-Fen Yang, Tian-Tuo Zhang, De-Yun Wang
Background: Aberrant epithelial remodeling and/or abnormalities in mucociliary apparatus in airway epithelium contribute to infection and inflammation. It is uncertain if these changes occur in both large and small airways in non-cystic fibrosis bronchiectasis (non-CF bronchiectasis). In this study, we aim to investigate the histopathology and inflammatory profile in the epithelium of bronchi and bronchioles in bronchiectasis. Methods: Excised lung tissue sections from 52 patients with non-CF bronchiectasis were stained with specific cellular markers and analyzed by immunohistochemistry and immunofluorescence to assess the epithelial structures, including ciliated cells and goblet cells morphology...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29549834/interferon-lambda-receptor-1-ifnl1r-transcript-is-highly-expressed-in-rhinovirus-bronchiolitis-and-correlates-with-disease-severity
#6
Alessandra Pierangeli, Maura Statzu, Raffaella Nenna, Letizia Santinelli, Laura Petrarca, Antonella Frassanito, Massimo Gentile, Guido Antonelli, Fabio Midulla, Carolina Scagnolari
BACKGROUND: As the expression of type III IFN receptor is restricted to the mucosal surfaces, its evaluation could be crucial to characterize the role of IFNλs during bronchiolitis. OBJECTIVES: This study was designed to investigate airway type III IFN receptor (IFNLR1/IL10RB) expression during respiratory syncytial virus (RSV) or human rhinovirus (HRV) bronchiolitis. STUDY DESIGN: Seventy-one 1-6 month old infants hospitalized with their first episode of acute RSV or HRV bronchiolitis were selected for this study...
May 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29222007/current-concepts-in-pathogenesis-diagnosis-and-management-of-smoking-related-interstitial-lung-diseases
#7
REVIEW
Anupam Kumar, Sujith V Cherian, Robert Vassallo, Eunhee S Yi, Jay H Ryu
Tobacco exposure results in various changes to the airways and lung parenchyma. Although emphysema represents the more common injury pattern, in some individuals, cigarette smoke injures alveolar epithelial cells and other lung cells, resulting in diffuse infiltrates and parenchymal fibrosis. Smoking can trigger interstitial injury patterns mediated via recruitment and inappropriate persistence of myeloid and other immune cells, including eosinophils. As our understanding of the role of cigarette smoke constituents in triggering lung injury continues to evolve, so does our recognition of the spectrum of smoking-related interstitial lung changes...
August 2018: Chest
https://www.readbyqxmd.com/read/28914741/eosinophilic-bronchiolitis
#8
Haruka Sato, Fumito Okada, Shunro Matsumoto, Asami Ono, Tomoko Nakayama, Hiromu Mori, Tomoko Ono, Yuko Usagawa, Junichi Kadota
No abstract text is available yet for this article.
November 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28598702/a-safe-and-efficient-bcg-vectored-vaccine-to-prevent-the-disease-caused-by-the-human-respiratory-syncytial-virus
#9
REVIEW
Emma Rey-Jurado, Jorge Soto, Nicolás Gálvez, Alexis M Kalergis
The human Respiratory Syncytial Virus (hRSV) causes lower respiratory tract infections including pneumonia and bronchiolitis. Such infections also cause a large number of hospitalizations and affects mainly newborns, young children and the elderly worldwide. Symptoms associated with hRSV infection are due to an exacerbated immune response characterized by low levels of IFN-γ, recruitment of neutrophils and eosinophils to the site of infection and lung damage. Although hRSV is a major health problem, no vaccines are currently available...
September 2, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28570692/natural-killer-t-cell-sensitization-during-neonatal-respiratory-syncytial-virus-infection-induces-eosinophilic-lung-disease-in-re-infected-adult-mice
#10
Seung Young Lee, Youran Noh, Jung Hyun Goo, Semi Rho, Min Jung Kim, Chang-Yuil Kang, Manki Song, Jae-Ouk Kim
Respiratory syncytial virus (RSV) is a major viral pathogen that causes severe lower respiratory tract infections in infants and the elderly worldwide. Infants with severe RSV bronchiolitis tend to experience more wheezing and asthma in later childhood. Because invariant natural killer T (iNKT) cells are associated with the asthma pathology, we investigated whether neonatal iNKT cells are involved in the aggravation of pulmonary diseases following RSV infection in mice. Intranasal exposure to the iNKT cell ligand α-galactosylceramide (α-GC) with RSV primary infection in neonatal mice elicited neither cytokine production (except for a slight increase of IL-5) nor pulmonary eosinophilia, despite the presence of both CD1d+ cells and NKT cells...
2017: PloS One
https://www.readbyqxmd.com/read/28273842/immunological-features-of-respiratory-syncytial-virus-caused-pneumonia-implications-for-vaccine-design
#11
REVIEW
Emma Rey-Jurado, Alexis M Kalergis
The human respiratory syncytial virus (hRSV) is the causative agent for high rates of hospitalizations due to viral bronchiolitis and pneumonia worldwide. Such a disease is characterized by an infection of epithelial cells of the distal airways that leads to inflammation and subsequently to respiratory failure. Upon infection, different pattern recognition receptors recognize the virus and trigger the innate immune response against the hRSV. Further, T cell immunity plays an important role for virus clearance...
March 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28079597/histologic-findings-of-severe-therapy-resistant-asthma-from-video-assisted-thoracoscopic-surgery-biopsies
#12
Humberto E Trejo Bittar, Daniel Doberer, Mitra Mehrad, Diane C Strollo, Joseph K Leader, Sally Wenzel, Samuel A Yousem
The histologic changes occurring in severe/therapy-resistant asthma (SA) as defined by the European Respiratory Society/American Thoracic Society guidelines, particularly at the level of the distal airways are unknown. This study describes the clinical, radiologic, and histologic characteristics of 29 SA patients who underwent video-assisted thoracoscopic surgery lung biopsy. Pathologic observations were correlated with clinical features, especially the presence of autoimmune disease (AID) (15/29, 51.7%). Ten biopsies (10/29, 34...
February 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27984136/pathology-of-diacetyl-and-2-3-pentanedione-airway-lesions-in-a-rat-model-of-obliterative-bronchiolitis
#13
Gordon P Flake, Daniel L Morgan
Inhalation of diacetyl vapors by workers has been associated with obliterative bronchiolitis (OB), a poorly understood fibroproliferative disease of the small airways. Significant insights into the pathogenesis of OB have been obtained through the use of a rat model. Inhalation exposure of rats to diacetyl or 2,3-pentanedione, a related flavoring agent, can cause severe injury to the airway epithelium and underlying basement membrane. Repeated exposure to diacetyl or 2,3-pentanedione leads to aberrant repair, fibroproliferation and partial to complete occlusion of the airway lumen...
August 1, 2017: Toxicology
https://www.readbyqxmd.com/read/27933655/immunological-diversity-in-phenotypes-of-chronic-lung-allograft-dysfunction-a-comprehensive-immunohistochemical-analysis
#14
COMPARATIVE STUDY
Elly Vandermeulen, Elise Lammertyn, Stijn E Verleden, David Ruttens, Hannelore Bellon, Mario Ricciardi, Jana Somers, Ken R Bracke, Kathleen Van Den Eynde, Thomas Tousseyn, Guy G Brusselle, Erik K Verbeken, Johny Verschakelen, Marie-Paule Emonds, Dirk E Van Raemdonck, Geert M Verleden, Robin Vos, Bart M Vanaudenaerde
Chronic rejection after organ transplantation is defined as a humoral- and cell-mediated immune response directed against the allograft. In lung transplantation, chronic rejection is nowadays clinically defined as a cause of chronic lung allograft dysfunction (CLAD), consisting of different clinical phenotypes including restrictive allograft syndrome (RAS) and bronchiolitis obliterans syndrome (BOS). However, the differential role of humoral and cellular immunity is not investigated up to now. Explant lungs of patients with end-stage BOS (n = 19) and RAS (n = 18) were assessed for the presence of lymphoid (B and T cells) and myeloid cells (dendritic cells, eosinophils, mast cells, neutrophils, and macrophages) and compared to nontransplant control lung biopsies (n = 21)...
February 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27798551/risk-factors-for-virus-induced-acute-respiratory-tract-infections-in-children-younger-than-3-years-and-recurrent-wheezing-at-36-months-follow-up-after-discharge
#15
Ambra Nicolai, Antonella Frassanito, Raffaella Nenna, Giulia Cangiano, Laura Petrarca, Paola Papoff, Alessandra Pierangeli, Carolina Scagnolari, Corrado Moretti, Fabio Midulla
BACKGROUND: We sought to know more about how 14 common respiratory viruses manifest clinically, and to identify risk factors for specific virus-induced acute respiratory tract infections (ARTIs) in children younger than 3 years old and for wheezing at 36-month follow-up. METHODS: We retrospectively studied the clinical records for 273 full-term children (median age, 2.9 months; range, 0.26-39; boys, 61.2%) hospitalized for ARTIs, whose nasopharyngeal specimen tested positive for a respiratory virus and 101 children with no history of respiratory diseases (median age, 8 months; range, 0...
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27719975/clinical-radiologic-pathologic-correlation-of-smoking-related-diffuse-parenchymal-lung-disease
#16
REVIEW
Seth Kligerman, Teri J Franks, Jeffrey R Galvin
The direct toxicity of cigarette smoke and the body's subsequent response to this lung injury leads to a wide array of pathologic manifestations and disease states that lead to both reversible and irreversible injury to the large airways, small airways, alveolar walls, and alveolar spaces. These include emphysema, bronchitis, bronchiolitis, acute eosinophilic pneumonia, pulmonary Langerhans cell histiocytosis, respiratory bronchiolitis, desquamative interstitial pneumonia, and pulmonary fibrosis. Although these various forms of injury have different pathologic and imaging manifestations, they are all part of the spectrum of smoking-related diffuse parenchymal lung disease...
November 2016: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/27660154/transbronchial-cryobiopsy-in-diffuse-parenchymal-lung-disease-retrospective-analysis-of-74-cases
#17
Kamonpun Ussavarungsi, Ryan M Kern, Anja C Roden, Jay H Ryu, Eric S Edell
BACKGROUND: Diagnostic evaluation of patients with diffuse parenchymal lung disease (DPLD) is best achieved by a multidisciplinary team correlating clinical, radiological, and pathologic features. Surgical lung biopsy remains the gold standard for histopathologic diagnosis of idiopathic interstitial pneumonias. Emerging data suggest an increasing role for transbronchial cryobiopsy (TBC) in DPLD evaluation. We describe our experience with TBC in patients with DPLD. METHODS: We retrospectively reviewed medical records of patients with radiographic features of DPLD who underwent TBC at Mayo Clinic in Rochester, Minnesota from June 2013 to September 2015...
February 2017: Chest
https://www.readbyqxmd.com/read/27658983/a-hur-tgf-%C3%AE-1-feedback-circuit-regulates-airway-remodeling-in-airway-smooth-muscle-cells
#18
Na Wang, Di Yan, Yi Liu, Yao Liu, Xianmin Gu, Jian Sun, Fei Long, Shujuan Jiang
BACKGROUND: Asthma is a worldwide health burden with an alarming prevalence. For years, asthma-associated airway injury remains elusive. Transforming growth factor β1 (TGF-β1) is a pleiotropic cytokine that has been shown to be involved in the synthesis of the matrix molecules associated with airway remodeling. Human antigen R (HuR), the member of the Hu RNA-binding protein family, can bind to a subset of short-lived mRNAs in their 3' untranslated regions (UTR). However, the functional roles and relevant signaling pathways of HuR in airway remodeling have not been well illustrated...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27640404/migrating-persistent-pulmonary-consolidation-in-a-child-a-case-of-follicular-bronchiolitis
#19
Yeongsang Jeong, Yong Hyun Bang, Yun-Kyung Kim
Migrating pulmonary lesions in children are uncommon, and most are caused by eosinophilic lung disease and parasite, fungus, and tuberculosis infections. A 12-year-old boy was referred to our hospital because of an abnormal chest x-ray. Serial computed tomography scans performed over several months showed a migrating pulmonary consolidation in the left lung, although the patient remained asymptomatic. Finally, surgical biopsy was performed and follicular bronchiolitis was diagnosed. The consolidation disappeared 17 months later without treatment, and the patient has remained asymptomatic...
May 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27560829/the-helminth-derived-immunomodulator-avcystatin-reduces-virus-enhanced-inflammation-by-induction-of-regulatory-il-10-t-cells
#20
Martijn J Schuijs, Susanne Hartmann, Murray E Selkirk, Luke B Roberts, Peter J M Openshaw, Corinna Schnoeller
Respiratory Syncytial Virus (RSV) is a major pathogen causing low respiratory tract disease (bronchiolitis), primarily in infants. Helminthic infections may alter host immune responses to both helminths and to unrelated immune triggers. For example, we have previously shown that filarial cystatin (AvCystatin/Av17) ameliorates allergic airway inflammation. However, helminthic immunomodulators have so far not been tested in virus-induced disease. We now report that AvCystatin prevents Th2-based immunopathology in vaccine-enhanced RSV lung inflammation, a murine model for bronchiolitis...
2016: PloS One
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