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Extreme low birth weight

Elisa Mariani, Augusto Biasini, Lucia Marvulli, Silvia Martini, Arianna Aceti, Giacomo Faldella, Luigi Corvaglia, Alessandra Sansavini, Silvia Savini, Francesca Agostini, Marcello Stella, Erica Neri
Objective: The aim of this observational study was to evaluate the effects of two different protein intake regimes on feeding tolerance, in-hospital growth, anthropometric data and psychomotor outcome up to 24 months corrected age (CA) in extremely low birth-weight (ELBW; birth weight <1000 g) infants. Methods: During the period 2008-2013, 52 ELBW infants admitted at birth to two Neonatal Intensive Care Units of Emilia Romagna (Italy) were fed according to different protocols of protein fortification of human milk: an estimated protein intakes at maximum fortification levels of 3...
2018: Frontiers in Public Health
Hatice T Aksoy, Nilüfer Güzoğlu, Zeynep Eras, F Emre Canpolat, Nurdan Uraş
PURPOSE: To compare complete blood count (CBC) parameters in extremely low birth weight (ELBW) infants born to mothers with and without preeclampsia and to evaluate whether these parameters could be used to determine the prognosis of infants born to mothers with preeclampsia. METHOD: Thirty-eight infants of preeclamptic mothers (IPM) and 77 infants of non-preeclamptic mothers (INPM) were included in the study. The CBC parameters of ELBW infants were evaluated at the sixth hour of life...
September 22, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
Maria Vollsæter, Thomas Halvorsen, Trond Markestad, Knut Øymar, Per Magne Ueland, Klaus Meyer, Øivind Midttun, Anne-Lise Bjørke-Monsen
BACKGROUND: Preterm birth and low birth weight are associated with reduced nephron numbers and increased risk of hypertension and kidney disease in later life. AIMS: We tested the hypothesis that extremely preterm birth and intrauterine growth restriction is associated with decreased renal function in mid childhood. METHODS: At 11 years of age the following measures were obtained in a regional cohort of children born extremely premature (EP, i...
2018: PloS One
Anett Nagy, Anna Mária Beke, Renáta Cserjési, Rózsa Gráf, Magda Kalmár
INTRODUCTION: Owing to the rapid progress of the medical science and technology, the chances of survival of the extremely low birth weight (<1000 g) preterm babies have dramatically improved. Nevertheless, the research findings on their long-term developmental outcome are inconsistent. AIM: Our study has attempted to contribute to the understanding of the developmental mechanisms in the extremely low birth weight preterm infants and to the prediction of the developmental outcomes taking into account of the risk factors of development...
October 2018: Orvosi Hetilap
Swati Murthy, Pamela R Parker, Steven J Gross
OBJECTIVE: We examined the effect of two strategies to prevent necrotizing enterocolitis (NEC) in extremely low birth weight (ELBW) infants-adherence to a standardized feeding protocol and use of a hospital-based milk bank to provide exclusive preterm human milk feedings. STUDY DESIGN: We conducted a single-center observational study from 2010 to 2015. Infants received preterm human milk, initially trophic feeds from days 7 to 14 after birth, followed by advancement of 15 mL/kg/day to reach a goal of 180 mL/kg/day...
October 5, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Charles T Wood, Olivia Linthavong, Eliana M Perrin, Alan Leviton, Elizabeth N Allred, Karl C K Kuban, T Michael O'Shea
BACKGROUND: Childhood obesity is a pervasive public health problem with risk factors such as maternal prepregnancy BMI and rapid infant weight gain. Although catch-up weight gain promotes more favorable neurodevelopment among infants born preterm, it is not clear whether faster weight gain early in life, or other correlates of preterm birth, are associated with later obesity in this population. METHODS: We used prospective data from the multicenter, observational Extremely Low Gestational Age Newborn Study...
October 5, 2018: Pediatrics
Roxanne Bélanger, Chantal Mayer-Crittenden, Michèle Minor-Corriveau, Manon Robillard
Purpose: The developing brain of a premature infant is vulnerable to injury. As a result, the long-term consequences of a premature birth include motor deficits, cognitive and behavioural problems. It is crucial to identify motor dysfunction during the preschool period because it interferes with a child's ability to explore the world. The goals of this study were to (1) provide preliminary data on the gross motor outcomes of children born prematurely and (2) determine the proportion and characteristics of the children who had maintained delays over the course of follow-up...
2018: Physiotherapy Canada. Physiothérapie Canada
Shyam Sathanandam, Kaitlin Balduf, Sandeep Chilakala, Kristen Washington, Kimberly Allen, Christopher Knott-Craig, Benjamin Rush Waller, Ranjit Philip
BACKGROUND: Patent ductus arteriosus (PDA) is common in extremely low birth weight (ELBW) infants. The objectives of this study were to describe our early clinical experience of transcatheter PDA closure (TCPC) in ELBW infants, compare outcomes with surgical ligation of PDA (SLP), and identify risk factors for prolonged respiratory support. METHODS: A retrospective review was performed comparing infants born <27 weeks, weighing <1 kg at birth and < 2 kg during TCPC with 2:1 propensity-score matched group of infants that underwent SLP...
September 30, 2018: Catheterization and Cardiovascular Interventions
Maria Rosales-Rueda
This paper investigates the persistent effects of negative shocks in utero and in infancy on low-income children's health and cognitive outcomes and examines whether timing of exposure matters differentially by skill type. Specifically, I exploit the geographic intensity of extreme floods in Ecuador during the 1997-1998 El Niño phenomenon, which provides exogenous variation in exposure at different periods of early development. I show that children exposed to severe floods in utero, especially during the third trimester, are shorter in stature five and seven years later...
August 17, 2018: Journal of Health Economics
K L Hon, S Liu, J Cy Chow, K Yc Tsang, H S Lam, K W So, Y Ky Cheng, A Kc Leung, W Wong
BACKGROUND: Extremely low birth weight (ELBW) infants exhibit high rates of mortality and morbidity. We retrospectively assessed factors associated with mortality and morbidity among ELBW infants. METHODS: Perinatal demographic data were reviewed for all ELBW infants born between 2010 and 2017 at a tertiary neonatal unit. RESULTS: For non-survivors (21% of ELBW infants) and survivors, the median gestational ages were 24.1 and 26.2 weeks, respectively, and median birth weights were 650 g and 780 g, respectively (all P<0...
October 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
F J Murcia Pascual, J I Garrido Pérez, A Siu Uribe, V Vargas Cruz, L Delgado Cotán, F Vázquez Rueda, R M Paredes Esteban
OBJECTIVES: The management of advanced necrotizing enterocolitis (NEC) in preterm birth with low weight remains controversial. The aim of this study consists in the analysis of the results of treatment in these patients, as well as the evaluation of the role of peritoneal drainage as a definitive therapeutic option. METHODS: Observational and descriptive study of 31 patients under 1,500 g of weight with advanced NEC, whom have had surgery in our center in the last 15 years...
August 3, 2018: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
A J Solaz-García, L Segovia-Navarro, J L Rodríguez de Dios-Benlloch, L Benavent-Taengua, D Y Castilla-Rodríguez, M A Company-Morenza
INTRODUCTION: Delayed meconium expulsion is a cause of bowel obstruction in the extremely premature newborn (<28 WGE) weighing less than 1500g at birth. OBJECTIVE: To evaluate the efficacy of conservative treatment in the prevention of meconium obstruction in very-low-birt- weight preterm infants. METHOD: Descriptive and retrospective study performed at the Neonatal Intensive Care Unit of a tertiary level hospital. All very-low-birth-weight preterm infants who were born during the study period, from August 2016 to January 2017, and who had meconium obstruction were included...
September 20, 2018: Enfermería Intensiva
Kazuya Matsumura, Yohei Matsuzaki, Mariko Hida, Kazushige Ikeda, Midori Awazu
BACKGROUND: Extremely low birth weight (ELBW) survivors may develop glomerulosclerosis due to low nephron number, whereas their tubular function remains unknown except for hypercalciuria and phosphaturia. METHODS: Fifty-three subjects (30 boys and 23 girls, aged 7 months-19 years, median 36 months) were studied retrospectively. The median gestational age and birth weight were 26 weeks (range 22-32) and 745 g (range 316-999), respectively. Urine calcium-to-creatinine ratio (Ca/Cr), N-acetyl-β-D-glucosaminidase-to-creatinine ratio (NAG/Cr), β2 microglobulin-to-creatinine ratio (β2m/Cr), uric acid-to-creatinine ratio (UA/Cr), glucose-to-creatinine ratio (glu/Cr), and microalbumin-to-creatinine ratio (malb/Cr) were examined...
September 20, 2018: Clinical and Experimental Nephrology
Yuichiro Miura, Tatsuya Watanabe, Toshihiko Uchida, Tatsuro Nawa, Naobumi Endo, Taichi Fukuzawa, Ryuji Ohkubo, Junji Takeyama, Ayako Sasaki, Kiyoshi Hayasaka
Congenital central hypoventilation syndrome is a disorder of respiratory control caused by mutations in the paired-like homeobox 2B gene. Mutations in the paired-like homeobox 2B gene are also responsible for Hirschsprung's disease. Variant Hirschsprung's disease is a rarer disorder that does not meet the diagnostic criteria of Hirschsprung's disease, although severe functional bowel obstruction persists. We present a case of an extremely low birth weight infant with congenital central hypoventilation syndrome and variant Hirschsprung's disease...
September 15, 2018: European Journal of Medical Genetics
Virginia Diaz, Edgardo Abalos, Guillermo Carroli
BACKGROUND: Almost 358,000 women die each year in childbirth, mainly in low-income countries. More than half of all maternal deaths occur within 24 hours of giving birth; severe bleeding in the postpartum period is the single most important cause. Depending on the rate of blood loss and other factors, such as pre-existing anaemia, untreated postpartum haemorrhage (PPH) can lead to hypovolaemic shock, multi-organ dysfunction, and maternal death, within two to six hours.This review investigated different methods for estimating blood loss...
September 13, 2018: Cochrane Database of Systematic Reviews
Do-Hyun Kim
Neonates, especially extremely low birth weight infants, are among the groups of patients undergoing transfusion frequently. Since they are exposed to higher specific transfusion risks compared to the patients of other age groups, there are many special aspects that must be considered for transfusion therapy in neonates. The transfusion risks in neonates include adverse outcomes specific for preterm infants as well as increased metabolic, immunologic, and infectious complications. To reduce the risks of transfusion-transmitted cytomegalovirus infection and transfusion-associated graft-versus-host disease, leukoreduced and irradiated cellular blood products should be used for all neonates...
September 2018: Korean Journal of Pediatrics
Peter J Anderson, Katherine J Lee, Gehan Roberts, Megan M Spencer-Smith, Deanne K Thompson, Marc L Seal, Chiara Nosarti, Andrea Grehan, Elisha K Josev, Susan Gathercole, Lex W Doyle, Leona Pascoe
OBJECTIVE: To assess the effectiveness of Cogmed Working Memory Training compared with a placebo program in improving academic functioning 24 months post-training in extremely preterm/extremely low birth weight 7-year-olds. STUDY DESIGN: A multicenter double-blind, placebo-controlled randomized controlled trial was conducted across all tertiary neonatal hospitals in the state of Victoria, Australia. Participants were 91 extremely preterm/extremely low birth weight 7-year-old children born in Victoria in 2005...
August 31, 2018: Journal of Pediatrics
Fionnuala M Caulfield, Omolola A Ihidero, Marie Carroll, Margo Dunworth, Marie Hunt, Desmond McAuliffe, Roy K Philip
BACKGROUND: Emergency baptism remains an important emotional and spiritual element for many parents of critically ill infants in the neonatal unit. There is no published data available as to which neonates are baptised and their outcomes. OBJECTIVES: To evaluate trends, outcomes and characteristics of newborn infants baptised over a 15-year period in an Irish maternity hospital. METHODS: Retrospective study of infants baptised in University Maternity Hospital Limerick (UMHL) over a 15-year period...
August 27, 2018: Irish Journal of Medical Science
Qi Meng, Kosuke Inoue, Beate Ritz, Jørn Olsen, Zeyan Liew
Perfluoroalkyl substances (PFASs) are widespread industrial pollutants that are extremely persistent in the environment. A previous study in the Danish National Birth Cohort (DNBC) found prenatal perfluorooctanoate (PFOA) exposure was associated with decreased birth weight, but had insufficient statistical power to evaluate adverse birth outcomes. Here, we conducted additional analyses in three samples originating from the DNBC for 3535 mothers and infant pairs to evaluate associations between prenatal PFASs exposures and low birth weight and preterm birth...
August 24, 2018: International Journal of Environmental Research and Public Health
Kristie L Poole, Louis A Schmidt, Saroj Saigal, Michael H Boyle, Katherine M Morrison, Ryan J Van Lieshout
Although the developmental course of self-esteem has been examined in general population samples, there is a lack of research examining the trajectory of self-esteem in populations who experience unique developmental challenges. We compared the trajectory of self-esteem in extremely low birth weight (ELBW; <1000 grams) survivors and normal birth weight (NBW) controls from mid-adolescence through their early 30s. Self-esteem was reported during three follow-up periods (age 12-16, age 22-26, age 30-35). Adjusting for sex, chronic health problems, socioeconomic status, and social support, no difference was noted in self-esteem in the two groups in adolescence, but birth weight status predicted rate of change of self-esteem from adolescence to adulthood...
May 2018: Journal of Applied Developmental Psychology
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