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Extreme low birth weight

Brian A Darlow, Julia Martin, L John Horwood
OBJECTIVE: To assess the physical well-being and components of the metabolic syndrome in a national cohort of very low birth weight (VLBW) young adults and same age controls. STUDY DESIGN: The New Zealand VLBW Study cohort prospectively included all infants with birth weight <1500 g born in 1986, with 338 (82%) surviving to discharge home. Height and weight were measured at age 7-8 years. The VLBW cohort (n = 229; 71% alive) and term-born controls (n = 100) aged 27-29 years were clinically assessed in a single center over 2 days, including assessment for components of the metabolic syndrome...
December 10, 2018: Journal of Pediatrics
Andréa Araujo de Oliveira Cortines, Patrícia Corrêa-Faria, Liselotte Paulsson, Paulo Sucasas Costa, Luciane Rezende Costa
OBJECTIVE: Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake, and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants. SUBJECTS AND METHODS: In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Trained and calibrated dentists examined the oral cavity of these children to identify and categorize DDE...
December 7, 2018: Oral Diseases
P Thakore, A E Dunbar, E B Lindsay
A 710 g male infant was born at a referring hospital at a gestational age of 23 weeks and 2 days via vaginal delivery and was transferred to our facility at 14 days of age. His delivery was complicated by the breech presentation with difficult head extraction. The infant's initial course was significant for respiratory distress syndrome, grade III-IV intraventricular hemorrhage (IVH), acute kidney injury, and large PDA. On the day of life 29, a gradual increase in serum sodium level refractory to increasing total fluid volume was noted...
December 1, 2018: Journal of Neonatal-perinatal Medicine
Danielly S Santana, Renato T Souza, Fernanda G Surita, Juliana L Argenton, Cleide M Silva, Jose G Cecatti
Birth records as SINASC (Brazilian Live Birth Information System) are highlighted in uncommon conditions such as twin pregnancy whose prevalence rarely exceeds 2 to 3% of the total number of births. The objective of this study was to assess the prevalence of twin pregnancies in Brazil and their maternal and perinatal characteristics using data from the national birth e-Registry. All births in Brazil from 2011 to 2014 were assessed. Prevalence of twin pregnancies per region was assessed and correlated with the Human Development Index (HDI)...
2018: BioMed Research International
Milena Tana, Alessandra Lio, Chiara Tirone, Claudia Aurilia, Eloisa Tiberi, Francesca Serrao, Velia Purcaro, Mirta Corsello, Piero Catenazzi, Vito D'Andrea, Giovanni Barone, Cinzia Ricci, Roberta Pastorino, Giovanni Vento
Objective: To evaluate if weaning from high-frequency oscillatory ventilation (HFOV) directly to a non-invasive mode of respiratory support is feasible and results in successful extubation in extremely low birth weight (ELBW) infants. Design: Prospective observational study. Setting: Tertiary neonatal intensive care unit. Patients: One hundred and eight ELBW infants of 26.2±1.4 weeks of gestational age (GA) directly extubated from HFOV...
2018: BMJ paediatrics open
Shunsuke Araki, Shin Kato, Fumihiko Namba, Erika Ota
BACKGROUND: Vitamin A (VA) supplementation reduces the risk of developing bronchopulmonary dysplasia (BPD). However, a previous meta-analysis showed that VA had minimal efficacy for preventing BPD in very low birth weight infants (VLBWIs). AIMS: To elucidate the effects of VA supplementation for BPD prevention in extremely low birth weight infants (ELBWIs). STUDY DESIGN: This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
2018: PloS One
Despina D Briana, Aimilia-Eirini Papathanasiou, Stavroula Gavrili, Sophia Georgantzi, Antonios Marmarinos, Christos Christou, Konstantinos Voulgaris, Dimitrios Gourgiotis, Ariadne Malamitsi-Puchner
BACKGROUND/OBJECTIVE: To study the concentrations of preadipocyte factor-1 (Pref-1) -an inhibitor of adipocyte differentiation, implicated in adipose tissue metabolism, late metabolic disorders and fetal growth- in maternal and umbilical cord serum, as well as maternal milk and correlate above concentrations with intrauterine growth and other perinatal parameters. MATERIAL AND METHODS: Pref-1 concentrations were determined by ELISA in antepartum maternal and umbilical cord serum, as well as day 3 to 4 postpartum breast milk, deriving from 80 women, who delivered 40 appropriate (AGA), 20 large for gestational age (LGA) and 20 intrauterine growth restricted (IUGR) neonates, classified by the use of customized birth-weight standards adjusted for significant determinants of fetal growth...
November 17, 2018: Cytokine
Karen M Puopolo, William E Benitz, Theoklis E Zaoutis
Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm infants with very low birth weight are treated empirically with antibiotics for risk of EOS, often for prolonged periods, in the absence of a culture-confirmed infection. Retrospective studies have revealed that antibiotic exposures after birth are associated with multiple subsequent poor outcomes among preterm infants, making the risk/benefit balance of these antibiotic treatments uncertain...
November 19, 2018: Pediatrics
Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa
OBJECTIVES: The current prebirth cohort study investigated the relationship between maternal B vitamin intake during pregnancy and behavioral problems in Japanese children aged 5 years. METHODS: Subjects were 1199 mother-child pairs. Dietary intake was assessed using a diet history questionnaire. Emotional problems, conduct problems, hyperactivity problems, peer problems, and low prosocial behavior were examined using the Japanese parent-report version of the Strengths and Difficulties Questionnaire...
November 19, 2018: Nutritional Neuroscience
Andrew S Thagard, Peter G Napolitano, Allison S Bryant
Background: The interpregnancy interval (IPI) defines the time between two consecutive gestations. In the general population, women with IPIs that fall outside the recommended 18-24 month range appear to be at modestly increased risk for adverse obstetric outcomes. Objective: The aim of this review was to assess the impact of extremes in IPI in populations with an increased baseline risk for adverse obstetric outcomes due to disparities in health and health care, including racial and ethnic groups, adolescents, and those of lower socioeconomic status...
October 2018: Current Women's Health Reviews
Hitesh Agrawal, Benjamin Rush Waller, Sushitha Surendan, Shyam Sathanandam
Patent ductus arteriosus (PDA) in extremely low-birth-weight infants puts this vulnerable population at high risks of morbidity and mortality. Inclusion of a multidisciplinary team and newly available transcatheter PDA occlusion devices in the management of these infants can mitigate those risks and promote better long-term outcomes. It is important that specific techniques with venous-only approach outlined in this article be followed to achieve optimal results.
January 2019: Interventional Cardiology Clinics
Jacob Young, Calan Savoy, Louis A Schmidt, Saroj Saigal, Ryan J Van Lieshout
OBJECTIVES: To examine associations between parent-reported child sleep walking or talking, nightmares, and trouble sleeping at age eight and psychiatric problems in adulthood (age 30-35) in extremely low birth weight (ELBW; <1000 g) survivors and matched normal birth weight (NBW; >2500 g) control participants. METHODS: At age eight, parents of ELBW survivors and NBW control participants completed sleep items on the Child Behavior Checklist assessing the presence of sleep walking/talking, nightmares, or trouble sleeping...
September 29, 2018: Sleep Medicine
Soichi Shibuya, Eiji Miyazaki, Go Miyano, Takaaki Imaizumi, Takashi Mikami, Takanori Ochi, Hiroyuki Koga, Geoffrey J Lane, Tadaharu Okazaki, Atsuyuki Yamataka
PURPOSE: Laparoscopic percutaneous extraperitoneal closure (LPEC) has become routine for repairing pediatric inguinal hernia (IH). Reports on the effective repair of IH in challenging cases, such as extremely low birth weight infants (ELBWI) who become symptomatic soon after birth and have surgery before 1 year of age, are rare; and conventional herniotomy (CH) in ELBWI requires extensive experience of neonatal surgery. We compared LPEC with CH for treating ELBWI with IH. METHODS: Consecutive ELBWI with IH treated by either LPEC (n = 17) or CH (n = 22) before 1 year of age between 2012 and 2017 were reviewed...
November 2, 2018: Pediatric Surgery International
Hope K Lima, Xi Lin, Sheila K Jacobi, Caolai Man, Jeffrey Sommer, William Flowers, Anthony Blikslager, Liara Gonzalez, Jack Odle
Background: Like many species, pregnant swine mobilize and repartition body nutrient stores during extreme malnutrition to support fetal development. Objective: The objective of this study was to model chronic human maternal malnutrition and measure effects of methylating-vitamins (MVs, containing choline, folate, B-6, B-12, and riboflavin) and docosahexaenoic acid (DHA) supplementation on fetal growth and development. Methods: Pregnant gilts ( n  = 24) were either fully nourished (2...
March 2018: Current developments in nutrition
Victoria C Ziesenitz, Erin Fox, Mark Zocchi, Samira Samiee-Zafarghandy, Johannes N van den Anker, Maryann Mazer-Amirshahi
BACKGROUND: Prescription drug shortages have increased significantly during the past two decades and also impact drugs used in critical care and pediatrics. OBJECTIVES: To analyze drug shortages affecting medications used in neonatal intensive care units (NICUs). METHODS: Drug shortage data for the top 100 NICU drugs were retrieved from the University of Utah Drug Information Service from 2001 to 2016. Data were analyzed focusing on drug class, formulation, reason for shortage, and shortage duration...
November 1, 2018: Neonatology
Aiko Igarashi, Ikue Hata, Miori Yuasa, Takashi Okuno, Yusei Ohshima
Background Although hepatic infantile hemangioma (IH) may correlate with consumptive hypothyroidism consequent to the overexpression of thyroid hormone inactivating enzyme by hemangioma cells, hypothyroidism has been rarely recognized in infants with cutaneous hemangioma. Case presentation A male infant born at 28 weeks of gestational age with an extremely low birth weight (775 g) developed a massive cutaneous hemangioma on his neck and severe abdominal distension. Imaging examinations detected a small mass lesion in the brain but no hepatic hemangioma...
October 26, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Mitchell S Cappell, Stavros Nicholas Stavropoulos, David Friedel
AIM: To systematically review safety/efficacy of therapeutic endoscopic-retrograde-cholangiopancreatography (ERCP) performed during pregnancy, considering fetal viability, fetal teratogenicity, premature delivery, and future postpartum development of the infant. METHODS: Systematic computerized literature search performed using PubMed with the key words "ERCP" and "pregnancy". Two clinicians independently reviewed the literature, and decided on which articles to incorporate in this review based on consensus and preassigned priorities...
October 16, 2018: World Journal of Gastrointestinal Endoscopy
Hee-Beom Yang, Ji-Won Han, Joong Kee Youn, Chaeyoun Oh, Hyun-Young Kim, Sung Eun Jung
There are few reports on enterostomy closure (EC) timing for acute abdomen in extremely low birth weight (ELBW) patients. We retrospectively reviewed ELBW patients who underwent enterostomy formation (EF) and subsequent EC. We investigated baseline characteristics, surgical outcomes, and follow-up data of 55 patients and analyzed optimal timing by age at EC, enterostomy duration, and body weight (Bwt) at EC. The minimum p-value approach (MPA) using the Chi-squared test was used to determine each cut-off value...
October 24, 2018: Scientific Reports
J M Meyers, S Tan, E F Bell, A F Duncan, R Guillet, B J Stoll, C T D'Angio
OBJECTIVE: To compare neurodevelopmental outcomes in linear growth-restricted (LGR) infants born <29 weeks with and without weight gain out of proportion to linear growth. STUDY DESIGN: We compared 2-year neurodevelopmental outcomes between infants with and without LGR and between LGR infants with and without weight gain out of proportion to linear growth. The outcomes were Bayley-III cognitive, motor, and language scores, cerebral palsy, Gross Motor Function Classification System (GMFCS) level ≥ 2, and neurodevelopmental impairment...
October 23, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Laura Sillers, Sara C Handley, Jennifer R James, Elizabeth E Foglia
BACKGROUND: The most recent guidelines by the Neonatal Resuscitation Program recommend use of electrocardiography monitoring during advanced resuscitation. OBJECTIVE: We describe a case in whom detection of pulseless electrical activity (PEA) on electronic heart rate monitoring complicated delivery room management of an extremely low birth weight infant and offer suggestions for the identification of PEA for neonatal providers. CONCLUSION: Further prospective studies are needed to determine the true incidence of PEA in the delivery room setting as well as its prognosis in newborns...
October 23, 2018: Neonatology
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