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Cerebral aneurysm randomized

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https://www.readbyqxmd.com/read/30093204/efficacy-of-cilostazol-in-prevention-of-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage-a-meta-analysis
#1
Hamidreza Saber, Aaron Desai, Mohan Palla, Wazim Mohamed, Navid Seraji-Bozorgzad, Muhammed Ibrahim
OBJECTIVES: Cilostazol, a selective inhibitor of phosphodiesterase 3, may reduce symptomatic vasospasm and improve outcome in patients with aneurysmal subarachnoid hemorrhage considering its anti-platelet and vasodilatory effects. We aimed to analyze the effects of cilostazol on symptomatic vasospasm and clinical outcome among patients with aneurysmal subarachnoid hemorrhage (aSAH). PATIENTS AND METHODS: We searched PubMed and Embase databases to identify 1) prospective randomized trials, and 2) retrospective trials, between May 2009 and May 2017, that investigated the effect of cilostazol in patients with aneurysmal aSAH...
August 6, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/30080684/transcranial-doppler-in-the-diagnosis-of-cerebral-vasospasm-an-updated-meta-analysis
#2
Jean-Mathieu Mastantuono, Christophe Combescure, Nadia Elia, Martin R Tramèr, Christopher Lysakowski
OBJECTIVES: To evaluate the performance of transcranial Doppler and transcranial color-coded duplex Doppler in patients with cerebral vasospasm due to aneurysm rupture. Angiography was considered as the gold standard comparator. DATA SOURCES: Search in MEDLINE, Embase, and Central from January 2001 to October 2017, without language restriction. Bibliographies of retrieved articles were screened for additional studies. STUDY SELECTION: Randomized studies comparing transcranial Doppler or transcranial color-coded duplex Doppler with angiography in adults...
August 3, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/30075557/the-effect-of-anesthetic-agents-on-cerebral-vasospasms-after-subarachnoid-hemorrhage-a-retrospective-study
#3
Jong Wha Lee, Jae Hee Woo, Hee Jung Baik, Dong Yeon Kim, Ji Seon Chae, Na Rae Yang, Eui Kyo Seo
Cerebral vasospasm is the most important cause of morbidity after an aneurysm clipping in the early postoperative period. The aim of this retrospective study was to evaluate whether the incidence of vasospasms differs when using propofol or desflurane for an emergent aneurysm clipping.The data from 102 patients (50 in the propofol group, 52 in the desflurane group) were analyzed. The occurrence of vasospasm based on daily transcranial Doppler, angiography, and cerebral infarction during 14 days after surgery were compared by anesthetic agents...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30045274/knowledge-based-iterative-model-reconstruction-comparative-image-quality-with-low-tube-voltage-cerebral-ct-angiography
#4
RANDOMIZED CONTROLLED TRIAL
Xinrui Wang, Chengcheng Zhu, Jing Li, Andrew J Degnan, Tao Jiang, Jianping Lu
The aim of this study was to compare image quality of low tube voltage cerebral computed tomography angiography (CTA) reconstructed with knowledge-based iterative model reconstruction (IMR), filtered back projection (FBP), and hybrid iterative reconstruction (HIR).A total of 101 patients with suspected cerebrovascular diseases were enrolled and randomized into 2 groups, 100 kVp tube voltage (n = 53) and reduced tube voltage (80 kVp) (n = 48). Computed tomography data were reconstructed with IMR, FBP, and HIR algorithms...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30033486/dose-dependent-inhibitory-effects-of-cilostazol-on-delayed-cerebral-infarction-after-aneurysmal-subarachnoid-hemorrhage
#5
Hidenori Suzuki, Yoshinari Nakatsuka, Ryuta Yasuda, Masato Shiba, Yoichi Miura, Mio Terashima, Yume Suzuki, Koichi Hakozaki, Fuki Goto, Naoki Toma
Cilostazol is a selective inhibitor of phosphodiesterase type III that downregulates tenascin-C (TNC), a matricellular protein, which may cause delayed cerebral infarction after aneurysmal subarachnoid hemorrhage (SAH). The authors increased the dosage and evaluated the dose-dependent effects of cilostazol on delayed cerebral infarction and outcomes in SAH patients. This was a retrospective cohort study in a single center. One hundred fifty-six consecutive SAH patients including 67 patients of admission World Federation of Neurological Surgeons grades IV-V who underwent aneurysmal obliteration within 48 h post-SAH from 2007 to 2017 were analyzed...
July 23, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/30021063/stretchable-implantable-nanostructured-flow-diverter-system-for-quantification-of-intra-aneurysmal-hemodynamics
#6
Connor Howe, Saswat Mishra, Yun-Soung Kim, Yanfei Chen, Sang-Ho Ye, William R Wagner, Jae-Woong Jeong, Hun-Soo Byun, Jong-Hoon Kim, Youngjae Chun, Woon-Hong Yeo
Random weakening of an intracranial blood vessel results in abnormal blood flow into an aneurysmal sac. Recent advancements show that an implantable flow diverter, integrated with a medical stent, enables a highly effective treatment of cerebral aneurysms by guiding blood flow into the normal vessel path. None of such treatment systems, however, offers post-treatment monitoring to assess the progress of sac occlusion. Therefore, physicians rely heavily on either angiography or magnetic resonance imaging. Both methods require a dedicated facility with sophisticated equipment settings and time-consuming, cumbersome procedures...
July 20, 2018: ACS Nano
https://www.readbyqxmd.com/read/30014184/clinical-trial-protocol-phase-3-multicenter-randomized-double-blind-placebo-controlled-parallel-group-efficacy-and-safety-study-comparing-eg-1962-to-standard-of-care-oral-nimodipine-in-adults-with-aneurysmal-subarachnoid-hemorrhage-newton-2-nimodipine-microparticles
#7
Daniel Hänggi, Nima Etminan, Stephan A Mayer, E Francois Aldrich, Michael N Diringer, Erich Schmutzhard, Herbert J Faleck, David Ng, Benjamin R Saville, R Loch Macdonald
BACKGROUND: Nimodipine is the only drug approved in the treatment of aneurysmal subarachnoid hemorrhage (aSAH) in many countries. EG-1962, a product developed using the Precisa™ platform, is an extended-release microparticle formulation of nimodipine that can be administered intraventricularly or intracisternally. It was developed to test the hypothesis that delivering higher concentrations of extended-release nimodipine directly to the cerebrospinal fluid would provide superior efficacy compared to systemic administration...
July 16, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/30004285/surgical-or-endovascular-management-of-ruptured-intracranial-aneurysms-an-agreement-study
#8
Tim E Darsaut, Robert Fahed, R Loch Macdonald, Adam S Arthur, M Yashar S Kalani, Fuat Arikan, Daniel Roy, Alain Weill, Alain Bilocq, Jeremy L Rempel, Michael M Chow, Robert A Ashforth, J Max Findlay, Luis H Castro-Afonso, Miguel Chagnon, Guylaine Gevry, Jean Raymond
OBJECTIVE Ruptured intracranial aneurysms (RIAs) can be managed surgically or endovascularly. In this study, the authors aimed to measure the interobserver agreement in selecting the best management option for various patients with an RIA. METHODS The authors constructed an electronic portfolio of 42 cases of RIA in which an angiographic image along with a brief clinical vignette for each patient were displayed. Undisclosed to the responders was that the RIAs had been categorized as International Subarachnoid Aneurysm Trial (ISAT) (small, anterior-circulation, non-middle cerebral artery location, n = 18) and non-ISAT (n = 22) aneurysms; the non-ISAT group also included 2 basilar apex aneurysms for which a high number of endovascular choices was expected...
July 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29998428/prediction-of-delayed-cerebral-ischemia-with-cerebral-angiography-a-meta-analysis
#9
Gyanendra Kumar, Oana M Dumitrascu, Chia-Chun Chiang, Cumara B O'Carroll, Andrei V Alexandrov
OBJECT: Cerebral catheter angiography is the gold standard for diagnosing cerebral artery vasospasm (vasospasm) in aneurysmal subarachnoid hemorrhage (SAH). We have previously published a meta-analysis of prediction of delayed cerebral ischemia (DCI) from transcranial Doppler (TCD) evidence of vasospasm. Analogous data relating to prediction of DCI have not been previously collated for cerebral angiography nor reconciled against TCD. METHODS: We searched PUBMED, the Cochrane database, and clinicaltrials...
July 11, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29977363/glycerol-fructose-combined-with-vitamin-b6-is-beneficial-to-postoperative-recovery-of-patients-with-cerebral-aneurysm
#10
Xiya Chen, Ting Lei
The aim of the present study is to investigate whether glycerol fructose combined with vitamin B6 is beneficial to the postoperative recovery of patients with cerebral aneurysm (CA). A total of 134 patients receiving embolization of CA in the Central Hospital of Wuhan between February, 2013 and June, 2015 and were divided into observation and control groups according to the random number table method, with 67 cases in each group. The control was given vitamin B6 routine treatment, while the observation group received glycerol fructose on the basis of treatment in the control group...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29951958/a-systematic-review-of-outcome-measures-employed-in-aneurysmal-subarachnoid-hemorrhage-asah-clinical-research
#11
REVIEW
Christopher R Andersen, Emily Fitzgerald, Anthony Delaney, Simon Finfer
Consensus on appropriate outcome measures to use in aneurysmal subarachnoid hemorrhage (aSAH) research has not been established, although the transition toward a core outcome set (COS) would provide significant benefits. To inform COS development, we conducted a systematic review to identify outcome measures included in reports of randomized clinical trials (RCTs) of interventions in patients with aSAH. Ovid Medline, EMBASE, CINAHL, and CENTRAL were searched. RCTs investigating aSAH published between January 1996 and May 2015 were included...
June 27, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29924781/-therapeutic-policy-in-stenosis-of-the-internal-carotid-artery-combined-with-intracranial-vascular-malformation
#12
A I Khripun, A D Priamikov, A B Mironkov, L D Gulina
Presented herein is the world experience of surgical treatment and various tactical approaches in a combined lesion of the extracranial and intracranial portions of the internal carotid artery (ICA): a combination of its stenosis or occlusion with vascular malformation of the brain (a cerebral aneurysm, pathological anastomoses, arteriovenous malformations). Also pointed out is the prevalence of the pathology involved, followed by describing various types of surgical policy in this condition: staged and simultaneous interventions, endovascular and standard operative auxiliary techniques...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29882696/propofol-post-conditioning-after-temporary-clipping-reverses-oxidative-stress-in-aneurysm-surgery
#13
Di Guo, Yanli Li, Haiyun Wang, Xinyue Wang, Wei Hua, Qingkai Tang, Lumin Miao, Guolin Wang
Animal studies have demonstrated that propofol post-conditioning produces long-term neuroprotection in focal cerebral ischemia-reperfusion injury. However, whether propofol post-conditioning provides neuroprotection in human beings has never been explored. The aim of this study was to evaluate the role of propofol post-conditioning on oxidative stress and post-operative cognitive function following aneurysm clipping. Sixty patients undergoing intracranial aneurysm clipping were randomized into a propofol post-conditioning group or a sevoflurane group...
June 8, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29789153/adjunct-retrograde-cerebral-perfusion-provides-superior-outcomes-compared-with-hypothermic-circulatory-arrest-alone-a-meta-analysis
#14
David H Tian, Justin Weller, Shaheen Hasmat, Aung Oo, Paul Forrest, Hosen Kiat, Tristan D Yan
OBJECTIVE: Retrograde cerebral perfusion is becoming less frequently used as a method of neuroprotection during aortic surgery. The present meta-analysis aims to compare outcomes after arch surgery with hypothermic circulatory arrest versus hypothermic circulatory arrest + retrograde cerebral perfusion. METHODS: Electronic searches were performed using 7 databases from their inception to September 2016. Relevant comparative studies that included patient groups who underwent aortic arch surgery using hypothermic circulatory arrest with continuous retrograde cerebral perfusion or hypothermic circulatory arrest alone were identified, and data were extracted by 2 independent researchers...
April 21, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29770118/neuroinflammation-as-a-target-for-intervention-in-subarachnoid-hemorrhage
#15
REVIEW
Airton Leonardo de Oliveira Manoel, R Loch Macdonald
Aneurysmal subarachnoid hemorrhage (SAH) is a sub-type of hemorrhagic stroke associated with the highest rates of mortality and long-term neurological disabilities. Despite the improvement in the management of SAH patients and the reduction in case fatality in the last decades, disability and mortality remain high in this population. Brain injury can occur immediately and in the first days after SAH. This early brain injury can be due to physical effects on the brain such as increased intracranial pressure, herniations, intracerebral, intraventricular hemorrhage, and hydrocephalus...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29733918/complication-rate-of-intraarterial-treatment-of-severe-cerebral-vasospasm-after-subarachnoid-hemorrhage-with-nimodipine-and-percutaneous-transluminal-balloon-angioplasty-worth-the-risk
#16
Daniela Adami, Joachim Berkefeld, Johannes Platz, Jürgen Konczalla, Waltraud Pfeilschifter, Stefan Weidauer, Marlies Wagner
BACKGROUND AND PURPOSE: Delayed cerebral ischemia (DCI) is a complication of aneurysmal subarachnoid hemorrhage (SAH). Arterial cerebral vasospasm (CVS) is discussed as the main pathomechanism for DCI. Due to positive effects of per os nimodipine, intraarterial nimodipine application is used in patients with DCI. Further, percutaneous transluminal balloon angioplasty (PTA) is applied in focal high-grade spasm of intracranial arteries. However, clinical benefits of those techniques are unconfirmed in randomized trials so far, and complications might occur...
May 4, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29701554/long-term-results-of-middle-cerebral-artery-aneurysm-clipping-in-the-barrow-ruptured-aneurysm-trial
#17
Michael A Mooney, Elias D Simon, Scott Brigeman, Peter Nakaji, Joseph M Zabramski, Michael T Lawton, Robert F Spetzler
OBJECTIVE A direct comparison of endovascular versus microsurgical treatment of ruptured middle cerebral artery (MCA) aneurysms in randomized trials is lacking. As endovascular treatment strategies continue to evolve, the number of reports of endovascular treatment of these lesions is increasing. Herein, the authors report a detailed post hoc analysis of ruptured MCA aneurysms treated by microsurgical clipping from the Barrow Ruptured Aneurysm Trial (BRAT). METHODS The cases of patients enrolled in the BRAT who underwent microsurgical clipping for a ruptured MCA aneurysm were reviewed...
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682015/spinal-cerebrospinal-fluid-drainage-for-prevention-of-vasospasm-in-aneurysmal-subarachnoid-hemorrhage-a-prospective-randomized-controlled-study
#18
Sachin Anil Borkar, Manmohanjit Singh, Shashank Sharad Kale, Ashish Suri, Poodipedi Sarat Chandra, Rajender Kumar, Bhawani Shankar Sharma, Shailesh Gaikwad, Ashok Kumar Mahapatra
Introduction: Cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is a major cause of mortality and morbidity. Despite various treatment modalities, the optimal management of vasospasm remains elusive. In this regard; we undertook a prospective, randomized controlled study to evaluate the effectiveness of lumbar cerebrospinal fluid drainage (LCSFD) for prevention of cerebral vasospasm and its sequelae. Materials and Methods: Patients with aneurysmal SAH who met the inclusion criteria were randomized into two groups - Group I (30 patients) underwent LCSFD whereas Group II (30 patients) did not undergo LCSFD...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29674324/indications-for-the-performance-of-intracranial-endovascular-neurointerventional-procedures-a-scientific-statement-from-the-american-heart-association
#19
REVIEW
Clifford J Eskey, Philip M Meyers, Thanh N Nguyen, Sameer A Ansari, Mahesh Jayaraman, Cameron G McDougall, J Kevin DeMarco, William A Gray, David C Hess, Randall T Higashida, Dilip K Pandey, Constantino Peña, Hermann C Schumacher
Intracranial endovascular interventions provide effective and minimally invasive treatment of a broad spectrum of diseases. This area of expertise has continued to gain both wider application and greater depth as new and better techniques are developed and as landmark clinical studies are performed to guide their use. Some of the greatest advances since the last American Heart Association scientific statement on this topic have been made in the treatment of ischemic stroke from large intracranial vessel occlusion, with more effective devices and large randomized clinical trials showing striking therapeutic benefit...
May 22, 2018: Circulation
https://www.readbyqxmd.com/read/29653275/safety-and-efficacy-of-flow-diverter-treatment-for-aneurysm-in-small-cerebral-vessels-a-systematic-review-and-meta-analysis
#20
REVIEW
Yazhou Yan, Deyuan Zhu, Haishuang Tang, Qinghai Huang
PURPOSE: To clarify the safety and efficacy of flow diverter (FD) treatment for aneurysm in small cerebral vessels, we conducted a systematic review of the literature analyzing perioperative and long-term clinical and angiographic outcomes. METHODS: A comprehensive review of the up-to-date literature for studies with ≥10 patients related to FD treatment of small vessel aneurysms published was performed. Random-effects meta-analysis was used to pool the following outcomes: complete occlusion, technical procedural success, perioperative mortality, perioperative stroke, procedure-related morbidity and mortality, all complications, long-term mortality, and overall good outcome...
July 2018: World Neurosurgery
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