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https://www.readbyqxmd.com/read/30551490/mesenchymal-stem-cell-based-therapy-of-osteoarthritis-current-knowledge-and-future-perspectives
#1
REVIEW
C Randall Harrell, Bojana Simovic Markovic, Crissy Fellabaum, Aleksandar Arsenijevic, Vladislav Volarevic
Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions, meniscal damage, and synovitis. Innate immune cells (natural killer cells, macrophages, and mast cells) play the most important pathogenic role in the early inflammatory response, while cells of adaptive immunity (CD4 + Th1 lymphocytes and antibody producing B cells) significantly contribute to the development of chronic, relapsing course of inflammation in OA patients...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30550021/-knee-osteotomies-a-renaissance
#2
Benjamin Tschopp, Trieu Hoai Nam Ngo, Robin Martin
There is a regain of interest for knee osteotomies over the last decade. A better knowledge of their long-term benefits and potential adverse events has increased their importance in the treatment of unicompartmental osteoarthritis. Emerging indications result from increasing evidence that the control of knee alignment is crucial in knee instability, meniscal transplantation and cartilage repair.
December 12, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/30547410/utilizing-atlas-based-modeling-to-predict-knee-joint-cartilage-degeneration-data-from-the-osteoarthritis-initiative
#3
Mika E Mononen, Mimmi K Liukkonen, Rami K Korhonen
Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to build subject-specific knee models. Therefore, the objective of this study was to develop a template-based modeling method for rapid prediction of knee joint cartilage degeneration. Knee joint models for 21 subjects were constructed with two different template approaches (multiple templates and one template) based on the MRI data...
December 13, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/30542221/clinical-outcomes-after-combined-anterior-cruciate-ligament-and-anterolateral-ligament-reconstruction
#4
Jean-Romain Delaloye, Jozef Murar, Mauricio Gonzalez, Thiago Amaral, Vikram Kakatkar, Bertrand Sonnery-Cottet
Background: Graft rupture rate, return to sport and persistent rotational instability remain a concern postoperatively following anterior cruciate ligament (ACL) reconstruction. The anterolateral ligament (ALL) has recently been shown to act as a lateral knee stabilizer that helps improve rotational stability. To improve functional and clinical outcomes, a combined ACL reconstruction with an associated ALL reconstruction has been proposed. Purpose: The main purpose of this study was to evaluate the clinical outcomes of the combined ACL and ALL reconstruction...
December 2018: Techniques in Orthopaedics: TIO
https://www.readbyqxmd.com/read/30542220/the-anterolateral-ligament-is-not-the-whole-story-reconsidering-the-form-and-function-of-the-anterolateral-knee-and-its-contribution-to-rotatory-knee-instability
#5
Andrew J Sheean, Jason Shin, Neel K Patel, Jayson Lian, Daniel Guenther, Volker Musahl
The heterogeneity of available cadaveric, histologic, and radiographic results related to the anterolateral ligament (ALL) does not support its existence as a discrete anatomic structure. Moreover, focusing narrowly on the ALL in isolation, what has previously been referred to as "ALL myopia," obscures a thorough appreciation for the stability contributions of both capsular and extracapsular structures. We consider injury to the soft tissues of the anterolateral knee-the anterolateral complex-just one component of what is frequently found to be a spectrum of pathology observed in the rotationally unstable, anterior cruciate ligament (ACL)-deficient knee...
December 2018: Techniques in Orthopaedics: TIO
https://www.readbyqxmd.com/read/30540611/management-of-long-term-complications-in-the-setting-of-lateral-meniscal-deficiency-after-saucerization-of-a-discoid-lateral-meniscus-in-an-adolescent-patient-a-case-report-and-review-of-the-literature
#6
Ryan A Smith, Curtis D Vandenberg, J Lee Pace
CASE: A 14-year-old adolescent with bilateral discoid menisci who had previously undergone discoid meniscal saucerization presented with pain and mechanical knee symptoms bilaterally. She had a torn left discoid lateral meniscus, a right lateral meniscal deficiency with an associated osteochondral defect, and valgus collapse of the right femur. She underwent successful repair of the left discoid meniscus as well as a femoral osteotomy, a meniscal transplant, and an osteochondral allograft transplantation in the right knee...
December 12, 2018: JBJS Case Connector
https://www.readbyqxmd.com/read/30536862/cellular-and-chemical-gradients-to-engineer-the-meniscus-to-bone-insertion
#7
Leanne E Iannucci, Alexander J Boys, Mary Clare McCorry, Lara A Estroff, Lawrence J Bonassar
Tissue-engineered menisci hold promise as an alternative to allograft procedures but require a means of robust fixation to the native bone. The insertion of the meniscus into bone is critical for meniscal function and inclusion of a soft tissue-to-bone interface in a tissue engineered implant can aid in the fixation process. The native insertion is characterized by gradients in composition, tissue architecture, and cellular phenotype, which are all difficult to replicate. In this study, a soft tissue-to-bone interface is tissue engineered with a cellular gradient of fibrochondrocytes and mesenchymal stem cells and subjected to a biochemical gradient through a custom media diffusion bioreactor...
December 10, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/30533371/technique-for-arthroscopically-assisted-superficial-and-deep-medial-collateral-ligament-meniscotibial-ligament-repair-with-internal-brace-augmentation
#8
Aaron K Black, Calvin Schlepp, Matthew Zapf, John B Reid
Deep medial collateral ligament (MCL) injury leads to meniscal lift-off and extrusion of the medial meniscus, resulting in instability and increased medial compartment pressures with subsequent cartilage damage. Repair of the deep MCL meniscotibial ligament in concert with superficial MCL repair or reconstruction is intended to restore the native anatomy , stability, and function of the medial meniscus. We present an arthroscopically assisted technique using standard arthroscopy portals and a medial open approach...
November 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/30533368/outside-in-single-lasso-loop-technique-for-meniscal-repair-fast-economic-and-reproducible
#9
Jose Maria Silberberg Muiño, Alessandro Nilo Fulvi, Martin Gimenez, Jose Ramon Muina Rullan
The current understanding of the biomechanical role of the meniscus, in conjunction with the increasing efforts to achieve its preservation within the orthopaedic community during treatment of meniscal lesions, has prompted the development of different meniscal repair techniques. The outside-in technique is recommended for anterior horn and middle-segment meniscal tears and has been recognized as a low-cost procedure with a low incidence of complications. Diverse modifications of this technique have been published over the past decade...
November 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/30531827/ultrasonography-of-the-late-stage-knee-osteoarthritis-prior-to-total-knee-arthroplasty-comparison-of-the-ultrasonographic-radiographic-and-intra-operative-findings
#10
Mika T Nevalainen, Kyösti Kauppinen, Juho Pylväläinen, Konsta Pamilo, Maija Pesola, Marianne Haapea, Juhani Koski, Simo Saarakkala
The purpose of this study was to assess the effectiveness of the ultrasonography (US) on detecting osteoarthritis of the knee, and compare US and radiographic findings to intraoperative total knee arthroplasty (TKA) findings. Fifty-seven late-stage osteoarthritic knees undergoing TKA were evaluated with US and radiography. Standard knee US assessing femoral cartilage damage, osteophytes, effusion, synovitis, and meniscal extrusion was performed. On radiographs, osteophytes, joint space narrowing, and Kellgren-Lawrence grade were evaluated...
December 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30531327/how-do-race-and-insurance-status-affect-the-care-of-pediatric-anterior-cruciate-ligament-injuries
#11
Joshua T Bram, Nakul S Talathi, Neeraj M Patel, Christopher J DeFrancesco, Brendan M Striano, Theodore J Ganley
OBJECTIVE: To identify associations between race or insurance status and preoperative, intraoperative, and postoperative findings in a large cohort of pediatric anterior cruciate ligament (ACL) reconstructions. DESIGN: Retrospective cohort study. SETTING: Division of Orthopaedics at an urban tertiary care children's hospital. PATIENTS: 915 pediatric (<21) patients undergoing primary ACL reconstruction between January 2009 and May 2016...
November 28, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/30528853/appraisal-of-clinical-practice-guideline-knee-pain-and-mobility-impairments-meniscal-and-articular-cartilage-lesions-revision-2018
#12
Goris Nazari
No abstract text is available yet for this article.
December 6, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/30528724/influence-of-anterolateral-ligament-injuries-on-stability-and-second-look-arthroscopic-findings-after-allograft-transtibial-anterior-cruciate-ligament-reconstruction
#13
Jae-Sung Yoo, Sung-Hyun Kim, Hee-Gon Park, Sung-Hyun Yoon, Seung-Gwan Park
BACKGROUND: The purpose of this study was to evaluate the influence of anterolateral ligament (ALL) injuries on stability and second-look arthroscopic findings after anterior cruciate ligament (ACL) reconstruction. METHODS: One-hundred and nineteen consecutive patients underwent a second-look arthroscopic surgery after ACL reconstruction and magnetic resonance imaging (MRI) examination of the ALL. The patients were divided into an ALL intact group (n = 39) and ALL injured group (n = 80)...
December 6, 2018: Knee
https://www.readbyqxmd.com/read/30527276/an-efficient-and-fast-computer-aided-method-for-fully-automated-diagnosis-of-meniscal-tears-from-magnetic-resonance-images
#14
Ahmet Saygılı, Songül Albayrak
Menisci are structures that directly affect movement, so early detection of meniscus tears also helps to prevent progressive knee disorders such as osteoarthritis. Manual segmentation of the menisci and diagnosis of the meniscal tear is a costly process in terms of time and effort for a radiologist. The aim of this study is to automatically determine the location and the type of meniscal tears that are important in the diagnosis and effective treatment of this problem. For this purpose, 29 different MR images, which were provided by Osteoarthritis Initiative (OAI), were used in the study...
December 4, 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/30525899/static-lateral-tibial-plateau-subluxation-predicts-high-grade-rotatory-knee-laxity-in-anterior-cruciate-ligament-deficient-knees
#15
Jayson Lian, João V Novaretti, Andrew J Sheean, Neel K Patel, Sean Whaley, Adam Popchak, Volker Musahl
BACKGROUND: In anterior cruciate ligament-deficient (ACL-D) knees, injury pattern and bony morphologic features have been shown to influence both static anterior tibial subluxation relative to the femur and dynamic rotatory knee laxity. Therefore, the relationship between static anterior tibial subluxation and dynamic rotatory knee laxity was investigated. PURPOSE: To determine whether static tibial subluxation as measured on magnetic resonance imaging (MRI) is associated with the grade of rotatory knee laxity in ACL-D knees...
December 7, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/30525875/quantitative-and-qualitative-assessment-of-the-posterior-medial-meniscus-anatomy-defining-meniscal-ramp-lesions
#16
Nicholas N DePhillipo, Gilbert Moatshe, Jorge Chahla, Zach S Aman, Hunter W Storaci, Elizabeth R Morris, Colin M Robbins, Lars Engebretsen, Robert F LaPrade
BACKGROUND: Meniscal ramp lesions have been defined as a tear of the peripheral attachment of the posterior horn of the medial meniscus (PHMM) at the meniscocapsular junction or an injury to the meniscotibial attachment. Precise anatomic descriptions of these structures are limited in the current literature. PURPOSE: To quantitatively and qualitatively describe the PHMM and posteromedial capsule anatomy pertaining to the location of a meniscal ramp lesion with reference to surgically relevant landmarks...
December 7, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/30514716/exercise-therapy-versus-arthroscopic-partial-meniscectomy-for-degenerative-meniscal-tear-in-middle-aged-patients-randomised-controlled-trial-with-two-year-follow-up
#17
(no author information available yet)
No abstract text is available yet for this article.
December 4, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/30511095/torn-discoid-lateral-meniscus-is-associated-with-increased-medial-meniscal-extrusion-and-worse-articular-cartilage-status-in-older-patients
#18
Zhong Zhang, Xiao-Ke Shang, Bei-Ni Mao, Jian Li, Gang Chen
PURPOSE: To compare the clinical, imaging, and arthroscopic characteristics of the torn discoid lateral meniscus (TDLM) in patients greater than 40 years of age with matched controls. METHODS: One hundred and ninety-four older patients (211 knees) who underwent arthroscopic surgery for a TDLM were consecutively recruited (Group 1). Another 211 age- and sex-matched controls with a torn semilunar lateral meniscus were included in this study (Group 2). Statistical analyses were used to determine the differences in the clinical, imaging, and arthroscopic characteristics between the two groups...
December 3, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/30509433/editorial-commentary-more-evidence-that-anterior-cruciate-ligament-deficiency-contributes-to-knee-arthritis-in-search-of-an-optimal-biomechanical-model
#19
EDITORIAL
Andrew G Geeslin
Patients with anterior cruciate ligament (ACL) tears have a greater incidence of knee arthritis than the general population. Acute chondral injury, acute or delayed meniscal pathology, and altered contact mechanics have all been implicated in the development of arthritis. Dynamic models (i.e., testing during simulated knee motion) have shown the biomechanical influence of ACL tears on knee laxity, although most investigations of contact mechanics rely on static models (i.e., testing during no relative tibiofemoral motion) wherein pressure distribution is mapped by thin films loaded in compression...
December 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/30509432/editorial-commentary-fresh-frozen-meniscal-allografts-cold-does-not-always-cause-shrinkage
#20
EDITORIAL
Brian J Cole, Neal B Naveen, Taylor M Southworth, Joseph N Liu
Meniscal allograft transplantation is an effective treatment for the symptomatic, young, active patient with meniscal deficiency. Modern graft-preservation techniques may reduce clinical sequelae of meniscal shrinkage after transplantation. We prefer fresh-frozen nonirradiated allografts because of easier processing, lower immunogenicity, and lower cost, and on the basis of a 2-decade clinical experience with fresh-frozen meniscal allograft transplantations, we are pleased with our survivorship results.
December 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
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