keyword
https://read.qxmd.com/read/38344730/systematic-review-of-the-link-between-oxford-mest-c-classification-and-complement-activation-in-iga%C3%A2-nephropathy
#21
JOURNAL ARTICLE
Gabriel Ștefan, Eric Alamartine, Christophe Mariat, Nicolas Maillard
INTRODUCTION: IgA nephropathy's (IgAN's) MEST-C classification relationship with complement activation is still not fully understood because of limited and conflicting evidence. Our study aimed to delineate this relationship through a systematic review. METHODS: We adhered to the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines and conducted a systematic review, utilizing databases like MEDLINE (PubMed), Embase, Scopus, and Cochrane from January 2016 (year of updated MEST-C classification) to January 2023...
February 2024: KI Reports
https://read.qxmd.com/read/38341430/association-study-of-the-complement-component-c4-gene-and-suicide-risk-in-schizophrenia
#22
JOURNAL ARTICLE
Mahbod Ebrahimi, Kowsar Teymouri, Cheng C Chen, Ayeshah G Mohiuddin, Jennie G Pouget, Vanessa F Goncalves, Arun K Tiwari, Clement C Zai, James L Kennedy
Schizophrenia is a severe mental illness and a major risk factor for suicide, with approximately 50% of schizophrenia patients attempting and 10% dying from suicide. Although genetic components play a significant role in schizophrenia risk, the underlying genetic risk factors for suicide are poorly understood. The complement component C4 gene, an immune gene involved in the innate immune system and located in the major histocompatibility complex (MHC) region, has been identified to be strongly associated with schizophrenia risk...
February 10, 2024: Schizophrenia (Heidelb)
https://read.qxmd.com/read/38329151/serum-concentrations-of-complement-c3-and-c4-in-dogs-with-idiopathic-epilepsy
#23
JOURNAL ARTICLE
Seonggweon Kang, Yoonhoi Koo, Taesik Yun, Yeon Chae, Dohee Lee, Hakhyun Kim, Mhan-Pyo Yang, Byeong-Teck Kang
BACKGROUND: High concentrations of complement factors are presented in serum of animal epilepsy models and human patients with epilepsy. OBJECTIVES: To determine whether complement dysregulation occurs in dogs with idiopathic epilepsy (IE). ANIMALS: The study included 49 dogs with IE subgrouped into treatment (n = 19), and nontreatment (n = 30), and 29 healthy dogs. METHODS: In this case-control study, the serum concentrations of the third (C3) and fourth (C4) components of the complement system were measured using a canine-specific ELISA kit...
February 8, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38328248/overexpression-of-the-schizophrenia-risk-gene-c4-in-pv-cells-drives-sex-dependent-behavioral-deficits-and-circuit-dysfunction
#24
Luke A Fournier, Rhushikesh A Phadke, Maria Salgado, Alison Brack, Sonia Bolshakova, Jaylyn R Grant, Nicole M Padró Luna, Alberto Cruz-Martín
Fast-spiking parvalbumin (PV)-positive cells are key players in orchestrating pyramidal neuron activity and thus serve an indispensable role in cognitive function and emotional regulation. Feed-forward excitatory inputs, essential for the function of PV cells, are disrupted in various neurological conditions, including schizophrenia (SCZ). However, it is not clear how disease-associated stressors such as immune dysregulation contribute to defects in particular cell types or neuronal circuits. We have developed a novel transgenic mouse line that permits conditional, cell-type specific overexpression (OE) of the immune complement component 4 ( C4 ) gene, which is highly associated with SCZ...
January 28, 2024: bioRxiv
https://read.qxmd.com/read/38326047/-efficacy-of-rituximab-therapy-for-10-patients-suffering-from-systemic-lupus-erythematosus-with-intestinal-involvement
#25
JOURNAL ARTICLE
Y R Zhao, Z Zhao, J Zhang, K P Li, J S Yang, F Sun, S M Liao, J L Zhang, F Huang, J Zhu
We retrospectively analyzed therapy efficacy and the adverse reactions of 10 patients suffering from systemic lupus erythematosus (SLE) with intestinal involvement treated with rituximab (RTX). Patients were hospitalized in the Department of Rheumatology and Immunology of the First Medical Center of PLA General Hospital from January 2015 to January 2023. Among the 10 patients, two were men and eight were women. The age of the cohort was (41.9±8.8) years. The age at disease onset was (28.8±9.2) years...
February 1, 2024: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://read.qxmd.com/read/38326043/-analyses-of-the-risk-factors-for-the-progression-of-primary-antiphospholipid-syndrome-to-systemic-lupus-erythematosus
#26
JOURNAL ARTICLE
S Y Chen, M M Zheng, C H Wang, H Jiang, J Li, J L Zhao, Y Zhao, R H Hou, X F Zeng
Objectives: Analyze the clinical characteristics of patients with primary antiphospholipid syndrome (PAPS) progressing to systemic lupus erythematosus (SLE).Explore the risk factors for the progression from PAPS to SLE. Methods: The clinical data of 262 patients with PAPS enrolled in Peking Union Medical College Hospital from February 2005 to September 2021 were evaluated. Assessments included demographic data, clinical manifestations, laboratory tests (serum levels of complement, anti-nuclear antibodies, anti-double-stranded DNA antibodies), treatment, and outcomes...
February 1, 2024: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://read.qxmd.com/read/38314205/association-of-urine-autoantibodies-with-disease-activity-in-systemic-lupus-erythematosus
#27
JOURNAL ARTICLE
Yuxian Zhang, Xiaoxia Qu, Lishui Wang, Lijun Song
OBJECTIVE: The presence of urinary autoantibodies in patients with systemic lupus erythematosus (SLE) has been confirmed by several studies; however, the significance of their presence in urine remains unclear. This study aims to further investigate the association between urine autoantibodies and disease activity as well as organ involvement in SLE. METHODS: This cross-sectional study included 89 SLE patients. Data collected included anti-nuclear antibody (ANA), anti-ENA antibodies, and anti-dsDNA antibody levels in both serum and urine, complement (C) 3, C4 levels in serum, SLE disease activity index-2000 (SLEDAI-2000), renal domains of SLEDAI (RSLEDAI) and non-renal SLEDAI (NRSLEDAI)...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38301948/lower-complement-c1q-levels-in-first-episode-psychosis-and-in-schizophrenia
#28
JOURNAL ARTICLE
Marja Koskuvi, Susmita Malwade, Jessica Gracias Lekander, Elin Hörbeck, Sanna Bruno, Jessica Holmen Larsson, Aurimantas Pelanis, Anniella Isgren, Anneli Goulding, Helena Fatouros-Bergman, Samudyata, Martin Schalling, Fredrik Piehl, Sophie Erhardt, Mikael Landen, Simon Cervenka, Funda Orhan, Carl M Sellgren
Recent evidence has implicated complement component (C) 4A in excessive elimination of synapses in schizophrenia. C4A is believed to contribute to physiological synapse removal through signaling within the C1q initiated classical activation axis of the complement system. So far, a potential involvement of C1q in the pathophysiology of schizophrenia remains unclear. In this study, we first utilized large-scale gene expression datasets (n = 586 patients with schizophrenia and n = 986 controls) to observe lower C1QA mRNA expression in prefrontal cortex tissue of individuals with schizophrenia (P = 4...
February 1, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38287556/relationship-between-cd274-gene-polymorphism-and-systemic-lupus-erythematosus-risk-in-a-chinese-han-population
#29
JOURNAL ARTICLE
Lu-Qi Yang, Zhen Qin, Lu Fu, Wang-Dong Xu
OBJECTIVE: Relationship between surface antigen differentiation cluster 274 (CD274) gene polymorphism and systemic lupus erythematosus (SLE) risk is limited. This study aims to discuss whether in a Chinese Han population, CD274 gene polymorphisms may relate to SLE susceptibility. METHODS: Three hundred and ten SLE patients and 390 healthy controls were included in this case-control study. Using the Kompetitive Allele-Specific PCR (KASP) approach, five single nucleotide polymorphisms (SNPs), including rs2890658, rs4143815, rs822339, rs2282055, and rs2297137, were genotyped for CD274 gene polymorphisms...
January 2024: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/38286181/lower-serum-amh-concentration-is-correlated-with-serum-igg1-decreased-in-the-infertile-woman-a-real-world-retrospective-study
#30
JOURNAL ARTICLE
Pan Wang, Lin Qi, Nan Yang, Yuting Xue, Jiansuo Zhou, Yonghua Wu, Tiancheng Wang, Liyuan Cui
OBJECTIVES: In this real-world approach, we examined the serum Anti-Mullerian Hormone (AMH) level and the relationship with serum IgG subclass in the infertile women. METHODS: A total of 574 female participants were recruited for this study. The serum AMH, IgG subclass(IgG1, IgG2, IgG3, IgG4) and immunoglobulin (Ig) G、IgM、IgA、IgE as well as complement C3 , C4 were analyzed. The difference in serum AMH level was assessed according categorized as above or below the median of the ratio of serum IgG subclass(IgG1, IgG2, IgG3, IgG4) to total IgG (RIgG subclass/IgG )...
January 28, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38285640/clonorchis-sinensis-infection-amplifies-hepatocellular-carcinoma-stemness-predicting-unfavorable-prognosis
#31
JOURNAL ARTICLE
Qiumei Lin, Zeli Tang, Yuling Qin, Xueling Deng, Caibiao Wei, Fengfei Liu, Xiaolan Pan, Dengyu Liu, Tingzheng Zhan, Min Fang
BACKGROUND: Extensive evidence links Clonorchis sinensis (C. sinensis) to cholangiocarcinoma; however, its association with hepatocellular carcinoma (HCC) is less acknowledged, and the underlying mechanism remains unclear. This study was designed to investigate the association between C. sinensis infection and HCC and reveal the relationship between C. sinensis infection and cancer stemness. METHODS: A comprehensive analysis of 839 HCC patients categorized into C...
January 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38283766/immunological-features-of-children-with-gastrointestinal-bleeding-due-to-henoch-sch%C3%A3-nlein-purpura
#32
JOURNAL ARTICLE
Lingrong Yang, Jing Guo, Fu Xiong
BACKGROUND: This study aims to evaluate the immunological features of gastrointestinal (GI) bleeding in children with Henoch-Schönlein purpura (HSP). STUDY DESIGN: This retrospective study was conducted on children with HSP. Demographic and clinical data were collected, including serum immunoglobulin (Ig) levels, complement C3 and C4 levels, and lymphocyte subtype percentage. RESULTS: A total of 446 hospitalized children had HSP. Eighty-six children with HSP had GI bleeding, 114 had proteinuria, and 107 had hematuria...
2024: Pediatric Health, Medicine and Therapeutics
https://read.qxmd.com/read/38265626/clinical-characteristics-of-lung-consolidation-with-mycoplasma-pneumoniae-pneumonia-and-risk-factors-for-mycoplasma-pneumoniae-necrotizing-pneumonia-in-children
#33
JOURNAL ARTICLE
Xue Zhang, Ruiyang Sun, Wanyu Jia, Peng Li, Chunlan Song
INTRODUCTION: Mycoplasma pneumoniae necrotizing pneumonia (MPNP) is an uncommon but increasingly recognized severe complication of pneumonia, and the delayed diagnosis and treatment are prone to pulmonary sequelae. The aim of this study is to explore independent risk factors for MPNP in children with lung consolidation. METHODS: A retrospective observational study was conducted on 118 children with MPNP (MPNP group) and 184 children with lung consolidation of Mycoplasma pneumoniae pneumonia (MPP) (control group) admitted to Children's Hospital Affiliated to Zhengzhou University from June 2018 to August 2023...
January 24, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38262166/anti-sft2d2-autoantibodies-alter-dendrite-spine-and-cause-psychotic-behavior-in-mice
#34
JOURNAL ARTICLE
Duilin Liu, Zhongman Jin, Hui Wei, Caiyun Zhu, Kejiang Liu, Pengsheng You, Jiahang Ju, Jinming Xu, Wanwan Zhu, Qi Xu
BACKGROUND: Autoimmunity plays an important role in schizophrenia (SCZ). Autoantibodies against SFT2D2 have been reported in patients with SCZ; however, the specific mechanism remains unclear. This study aimed to describe an autoimmune model, namely, mice immunized against SFT2D2-peptides. METHODS: ApoE-/- and WT mice (C57BL/6) were immunized four times (day 0, day 14, day 21, day 35) with SFT2D2 peptide or KLH via subcutaneous injection. Behavioral tests were conducted after the third immunization, and immunochemistry of brain tissue were performed after the sacrifice of the mice...
January 10, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38252367/complement-system-deficiencies-in-elite-athletes
#35
JOURNAL ARTICLE
Libor Vítek, Jana Woronyczova, Veronika Hanzikova, Helena Posová
BACKGROUND: Although regular physical activity improves immune competency and reduces the prevalence of inflammatory diseases, strenuous training in elite athletes is associated with an increased susceptibility to infectious complications. Therefore, the objective of our study was to assess the routinely examined parameters of the complement system in elite athletes. The study was carried out in a cohort of elite athletes (n = 134) and healthy control subjects (n = 110)...
January 22, 2024: Sports Medicine—Open
https://read.qxmd.com/read/38250251/the-spectrum-of-thrombotic-microangiopathy-related-to-monoclonal-gammopathy
#36
JOURNAL ARTICLE
Daan P C van Doorn, Myrurgia A Abdul-Hamid, Leon A M Frenken, Pieter van Paassen, Sjoerd A M E G Timmermans
BACKGROUND: Recent studies showed a high prevalence of monoclonal gammopathy (MG) in patients with thrombotic microangiopathy (TMA) aged over 50 years and suggested that complement dysregulation is pivotal for the disease to develop. Here, we studied this premise in seven patients with TMA and coexisting MG. METHODS: Patients with TMA on kidney biopsy and/or peripheral blood were recruited from the prospective COMPETE cohort (NCT04745195) and Limburg Renal Registry...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38243017/soluble-terminal-complement-complex-blood-levels-are-elevated-in-schizophrenia
#37
JOURNAL ARTICLE
Susa Savukoski, Marco Mannes, Lisa Wohlgemuth, Anke Schultze, Paul C Guest, Gabriela Meyer-Lotz, Henrik Dobrowolny, Borna Relja, Markus Huber-Lang, Johann Steiner
The role of the complement system in schizophrenia (Sz) is inconclusive due to heterogeneity of the disease and study designs. Here, we assessed the levels of complement activation products and functionality of the classical pathway in acutely ill unmedicated Sz patients at baseline and after 6 weeks of treatment versus matched controls. The study included analyses of the terminal complement complex (sTCC) and C5a in plasma from 96 patients and 96 controls by enzyme-linked immunosorbent assay. Sub-group analysis of serum was conducted for measurement of C4 component and activity of the classical pathway (28 and 24 cases per cohort, respectively)...
January 19, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38242261/comparative-transcriptome-analysis-reveals-potential-regulatory-mechanisms-of-genes-and-immune-pathways-following-vibrio-harveyi-infection-in-red-drum-sciaenops-ocellatus
#38
JOURNAL ARTICLE
Jiale Zhou, Jingyao Yu, Qing Chu
Red drum (Sciaenops ocellatus), as an important economical marine fish, has been affected by various bacterial diseases in recent years. Vibrio harveyi cause fatal vibriosis in S. ocellatus, leading to massive mortality and causing significant setbacks in aquaculture. However, the regulatory mechanisms of S. ocellatus response to V. harveyi infection are poorly understood. In this regard, we performed transcriptomic analysis with head kidney tissues of S. ocellatus after V. harveyi infection from 12 h to 48 h to reveal genes, gene expression profiles, and pathways involved in immune and inflammation responses...
January 17, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38232223/comparison-of-efficacy-of-continuous-mycophenolate-mofetil-with-sequential-cyclophosphamide-and-tacrolimus-as-maintenance-therapy-for-lupus-nephritis
#39
JOURNAL ARTICLE
Mai Kawazoe, Toshihiro Nanki
OBJECTIVES: To evaluate the renal response to mycophenolate mofetil (MMF) as maintenance therapy for lupus nephritis (LN) in Japanese patients, we compared the efficacy of MMF and the sequential use of monthly intravenous cyclophosphamide (IVCY) followed by tacrolimus (TAC). METHODS: We examined 14 patients with LN who were treated with continuous MMF as induction and maintenance therapies (MMF group) and 10 patients with LN who received monthly IVCY as induction therapy followed by maintenance therapy with TAC (IVCY-TAC group)...
January 17, 2024: Lupus
https://read.qxmd.com/read/38227433/complement-c4d-as-a-biomarker-for-systemic-lupus-erythematosus-and-lupus-nephritis
#40
REVIEW
Sihao Qin, Xueyao Wang, Jiahui Wang, Hao Wu
Background: Increasing studies in the last decade have led to the widespread understanding that C4d, a split product of complement component 4 (C4), is a potential biomarker for systemic lupus erythematosus (SLE) and lupus nephritis (LN). Purpose : The aim of this review is to summarize the highlights of studies investigating the use of C4d as a biomarker for diagnosing and monitoring SLE and LN patients. Data collection: we searched PubMed/Medline and Wanfang databases using the terms "C4d and systemic lupus erythematosus", "C4d and lupus nephritis", and "Complement C4d"...
February 2024: Lupus
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