Marja Koskuvi, Susmita Malwade, Jessica Gracias Lekander, Elin Hörbeck, Sanna Bruno, Jessica Holmen Larsson, Aurimantas Pelanis, Anniella Isgren, Anneli Goulding, Helena Fatouros-Bergman, Samudyata, Martin Schalling, Fredrik Piehl, Sophie Erhardt, Mikael Landen, Simon Cervenka, Funda Orhan, Carl M Sellgren
Recent evidence has implicated complement component (C) 4A in excessive elimination of synapses in schizophrenia. C4A is believed to contribute to physiological synapse removal through signaling within the C1q initiated classical activation axis of the complement system. So far, a potential involvement of C1q in the pathophysiology of schizophrenia remains unclear. In this study, we first utilized large-scale gene expression datasets (n = 586 patients with schizophrenia and n = 986 controls) to observe lower C1QA mRNA expression in prefrontal cortex tissue of individuals with schizophrenia (P = 4...
February 1, 2024: Brain, Behavior, and Immunity