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Complement c4

Durga Chougule, Milind Nadkar, Krishnamurthy Venkataraman, Anjali Rajadhyaksha, Niwrutti Hase, Tukaram Jamale, Seema Kini, Prasad Khadilkar, Vidya Anand, Manisha Madkaikar, Vandana Pradhan
BACKGROUND: Adipokines are chemical mediators released from adipose tissue involved in regulation of appetite, insulin sensitivity, immune system and inflammatory responses. Adipokines contributes to low grade inflammatory response in autoimmune disease like Systemic Lupus Erythematosus (SLE) but the pathophysiology is yet not clear. The aim of this study is to understand role of adipokine interactions in SLE disease pathogenesis. METHODS: Sixty newly diagnosed treatment naïve SLE patients fulfilling the ACR criteria and forty age-sex matched healthy subjects were enrolled in thiscase-control study...
August 8, 2018: Cytokine
Huimin Zhang, Hongrui Jiang, Yongliang Fan, Zhi Chen, Mingxun Li, Yongjiang Mao, Niel A Karrow, Juan J Loor, Stephen Moore, Zhangping Yang
Mastitis is a highly prevalent disease in dairy cows that causes large economic losses. Streptococcus agalactiae is a common contagious pathogen, and a major cause of bovine mastitis. The immune response to intramammary infection with S. agalactiae in dairy cows is a very complex biological process. In order to understand the host immune response to S. agalactiae-induced mastitis, mammary gland of lactating Chinese Holstein cows was challenged with S. agalactiae via nipple tube perfusion. Visual inspection, analysis of milk somatic cell counts, histopathology and transmission electron microscopy of mammary tissue was performed to confirm S...
August 10, 2018: Journal of Agricultural and Food Chemistry
Mohammadhossein Baradaranfar, Mohammadhossein Dadgarnia, Vahid Zand, Sedighe Vaziribozorg, Fatemeh Sadat Mirzade, Mojtaba Mirzade
Introduction: In this study, we examined the role of immunological factors on sudden sensory neural hearing loss (SSNHL). Materials and Methods: This prospective case-controlled study was performed in patients with SSNHL who referred to the ear, nose, and throat (ENT) ward. Fifty-six patients with SSNHLoccurring within a 72-hr period were selected as the case group and 56 participants who had no recent history of disease were assigned to the control group. Mean levels of immunological factors including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), antinuclear antibody (ANA), anti-neutrophil cytoplasmic antibody (ANCA) (C, P), anti-cyclic citrullinated peptide (anti-CCP), DSM, hemoglobin (Hb), complement component 3 (C3), and complement component 4 (C4) were evaluated in the blood samples in each group...
July 2018: Iranian Journal of Otorhinolaryngology
Aishwarya Ravindran, Fernando C Fervenza, Richard J H Smith, An S De Vriese, Sanjeev Sethi
OBJECTIVE: To describe the clinicopathological features, complement abnormalities, triggers, treatment, and outcomes of C3 glomerulopathy. PATIENTS AND METHODS: A total of 114 patients with C3 glomerulopathy seen at Mayo Clinic from January 1, 2007, through December 31, 2016, were evaluated in this study. RESULTS: The mean age at diagnosis for the entire cohort was 40.4±22.3 years, with a median serum creatinine level and proteinuria value of 1...
August 2018: Mayo Clinic Proceedings
Andrea Padoan, Daniela Basso, Carlo-Federico Zambon, Tommaso Prayer-Galetti, Giorgio Arrigoni, Dania Bozzato, Stefania Moz, Filiberto Zattoni, Rino Bellocco, Mario Plebani
Background: Lower urinary tract symptoms (LUTS) and prostate specific antigen-based parameters seem to have only a limited utility for the differential diagnosis of prostate cancer (PCa). MALDI-TOF/MS peptidomic profiling could be a useful diagnostic tool for biomarker discovery, although reproducibility issues have limited its applicability until now. The current study aimed to evaluate a new MALDI-TOF/MS candidate biomarker. Methods: Within- and between-subject variability of MALDI-TOF/MS-based peptidomic urine and serum analyses were evaluated in 20 and 15 healthy donors, respectively...
2018: Clinical Proteomics
Ting Qiu, Maria J Chiuchiolo, Adele S Whaley, Anthony R Russo, Dolan Sondhi, Stephen M Kaminsky, Ronald G Crystal, Odelya E Pagovich
BACKGROUND: Hereditary angioedema (HAE) is a life-threatening, autosomal dominant disorder characterized by unpredictable, episodic swelling of the face, upper airway, oropharynx, extremities, genitalia and gastrointestinal tract. Almost all cases of HAE are caused by mutations in the SERPING1 gene resulting in a deficiency in functional plasma C1 esterase inhibitor (C1EI), a serine protease inhibitor that normally inhibits proteases in the contact, complement, and fibrinolytic systems...
July 30, 2018: Allergy
A A Margery-Muir, C Bundell, J D Wetherall, R Whidborne, P Martinez, D M Groth
The relationship between serum concentration of complement C4 ([C4]) and C4 gene copy number (GCN) was investigated in 56 systemic lupus erythematosus (SLE) patients and 33 age and sex-matched controls in a Western Australian population. C4A and C4B gene copy numbers (C4A & B GCN) together with the presence or absence of the ≈6.4-kb human endogenous retroviral element type K (hereafter HERV-K) in intron 9 were estimated by two TaqMan™ real-time PCR (RT-PCR) assays that measured total C4 and HERV-K GCNs, respectively...
September 2018: Lupus
Rong Wang, Dafeng He, Lili Zhao, Shaoshan Liang, Dandan Liang, Feng Xu, Mingchao Zhang, Xiaodong Zhu, Huiping Chen, Honglang Xie, Caihong Zeng, Zheng Tang, Zhihong Liu
Hypocomplementaemia has been frequently reported in IgG4 related kidney disease (IgG4-RKD). However, studies on the role of complement system in IgG4-RKD are lacking. A total of 40429 renal biopsies from January 2010 to January 2018 were re-examined in the present study, and 17 patients were confirmed to meet the criteria of IgG4-RKD. According to the serum C3 levels, they were divided into two groups: the low C3 group (C3<0.8g/L, n=7) and the normal C3 group (C3≥0.8g/L, n=10). Compared with the normal C3 level group, the patients in the low C3 level group had lower serum C4 concentrations (P=...
July 18, 2018: Human Pathology
Konasale M Prasad, Kodavali V Chowdari, Leonardo A D'Aiuto, Satish Iyengar, Jeffrey A Stanley, Vishwajit L Nimgaonkar
A recent report suggested Complement 4 (C4A) gene copy numbers (GCN) as risk factors for schizophrenia. Rodent model showed association of C4 with synaptic pruning suggesting its pathophysiological significance (Sekar, A. et al. (2016)). We, therefore, predicted that C4A GCN would be positively correlated with neuropil contraction in the human brain among schizophrenia patients showing more prominent correlations in ventral regions among young adults and dorsal regions among adolescents since neuromaturation progresses dorsoventrally...
July 19, 2018: Translational Psychiatry
Hua-Xi Liu, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Yun-Yun Zeng, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Lin Feng
This study was for the first time to investigate the effects of α-lipoic acid (LA) on growth and immune function of head kidney, spleen and skin in young grass carp (Ctenopharyngodon idella). A total of 540 healthy grass carp (with initial body weight at 216.59 ± 0.33 g) were randomly divided into six groups and fed six separate diets with graded dietary levels of LA for 70 days. Un-supplemented group did not find LA and its concentrations in the other five diets were 203.25, 403.82, 591.42, 781.25 and 953...
September 2018: Fish & Shellfish Immunology
Yang Meng, Meng Zhang, Xiaozhen Zhao, Yongjing Cheng, Rulin Jia, Yan Wang, Xiaolin Sun
The pathological effects of thrombospondin-1 (TSP-1) have been studied in many preclinical tumor models and rheumatoid arthritis. However, the role of TSP-1 and anti-thrombospondin-1 autoantibodies (ATSA) in systemic lupus erythematosus (SLE) has not been specifically defined. In this study, we investigated the clinical relevance and functional significance of TSP-1 and ATSA in SLE patients. Serum levels of TSP-1 and ATSA were measured by ELISA in 138 adult SLE patients and 60 healthy controls. Blood cell counts, rheumatoid factor (RF), immunoglobulins, erythrocyte sedimentation rate (ESR), complements, and SLE-related autoantibodies were measured by standard laboratory techniques...
July 11, 2018: Clinical Rheumatology
Mischa P Keizer, Angela Kamp, Gerard van Mierlo, Taco W Kuijpers, Diana Wouters
The lectin pathway (LP) of complement activation depends on the activation of the MBL-associated serine proteases (MASPs) circulating in complex with mannan-binding lectin (MBL). MBL deficiency is the most common complement deficiency and has been associated with several pathological conditions. As we had previously shown, plasma-derived MBL (pdMBL) contains pre-activated MASPs that upon in vivo pdMBL substitution results in restoration of MBL concentrations but no LP functionality due to immediate inactivation of pdMBL-MASP complexes upon infusion...
2018: Frontiers in Immunology
Chengcheng Hou, Ou Jin, Xi Zhang
To investigate the clinical characteristics of infection in SLE patients and analyze the risk factors of infection. A retrospective analysis method was used and the data were collected from 173 case times of 142 hospitalized patients. We found the incidence rate of infections in SLE was 50.7%. The most common infection sites were lungs, followed by upper respiratory tracts and urinary tracts. The most common pathogens were bacteria, followed by fungi. The infection-associated risk factors were duration of hospitalization, lupus activity state, the use of high-dose corticosteroids and immunosuppressive agents, the low serum level of complements 3 and 4 (C3 and C4), fever, the high level of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), the abnormality of white blood cell (< 4 × 109 /L or > 10 × 109 /L), and the low level of albumin (P < 0...
July 9, 2018: Clinical Rheumatology
Amro M Hassan, Heba A Osman, Hasan S Mahmoud, Mohammed H Hassan, Abdel-Kader A Hashim, Hesham H Ameen
Background and aims: Hepatitis C virus (HCV) infection is associated with extrahepatic manifestations such as cryoglobulinemia and accounts for up to 90% of all cases of mixed cryoglobulinemia (MC). The present study aimed to evaluate the effect of sofosbuvir-daclatasvir therapy on symptomatic HCV-related MC and sustained virologic response (SVR) achievement. Patients and methods: This prospective cohort study was carried out on 120 patients with chronic HCV infection, clinically suspected to have MC, but only 63 of whom were positive for cryoglobulins...
2018: Infection and Drug Resistance
Edyta Skrzypek, Tomasz Warzecha, Angelika Noga, Marzena Warchoł, Ilona Czyczyło-Mysza, Kinga Dziurka, Izabela Marcińska, Kamila Kapłoniak, Agnieszka Sutkowska, Zygmunt Nita, Krystyna Werwińska, Dominika Idziak-Helmcke, Magdalena Rojek, Marta Hosiawa-Barańska
Background: The oat × maize addition (OMA) lines are used for mapping of the maize genome, the studies of centromere-specific histone (CENH3), gene expression, meiotic chromosome behavior and also for introducing maize C4 photosynthetic system to oat. The aim of our study was the identification and molecular-cytogenetic characterization of oat × maize hybrids. Methods: Oat DH lines and oat × maize hybrids were obtained using the wide crossing of Avena sativa L...
2018: PeerJ
Ahmed Abdelfattah Denewar, Mohamed Hamed Abbas, Hussein Attiya Sheashaa, Ibrahim Abdelaal, Khaled El-Dahshan, Yasser Elsayed Matter, Ayman Fathi Refaie
OBJECTIVES: Liver disease is an important cause of morbidity and mortality among recipients of transplanted organs. In addition to the liver, hepatitis C virus infection has a significant prevalence among recipients of kidney transplant and is related to worse graft and recipient survival as the kidney is an important component of the hepatitis C virus clinical syndrome. MATERIALS AND METHODS: This retrospective single center study included 336 patients with end-stage renal disease who received a kidney transplant at the Mansoura Urology and Nephrology Center from January 1992 to December 1995...
June 28, 2018: Experimental and Clinical Transplantation
Lysianne Pinto, Luiz Fernando Zmetek Granja, Mariana Amorim de Almeida, Daniela Sales Alviano, Maria Helena da Silva, Regina Ejzemberg, Sonia Rozental, Celuta Sales Alviano
BACKGROUND: Melanin production has been associated with virulence in various pathogenic fungi, including Fonsecaea pedrosoi, the major etiological agent for chromoblastomycosis, a subcutaneous fungal disease that occurs in South America. OBJECTIVE: The aim of this study was to evaluate the effects of acid-basic extracted F. pedrosoi melanin particles and fungal cell ghosts obtained by Novozym 234 treatment on their ability to activate the human complement system...
June 25, 2018: Memórias do Instituto Oswaldo Cruz
Valzimeire do Nascimento de Oliveira, Abelardo Barbosa Moreira Lima-Neto, Maurício Fraga van Tilburg, Ana Cristina de Oliveira Monteiro-Moreira, Marina Duarte Pinto Lobo, Davide Rondina, Virgínia Oliveira Fernandes, Ana Paula Dias Rangel Montenegro, Renan Magalhães Montenegro, Maria Izabel Florindo Guedes
Purpose: Type 1 diabetes mellitus (DM1) is one of the most common chronic diseases observed during childhood. The incidence of DM1 is increasing worldwide, and there is currently no way to prevent or delay the onset or to cure the disease. Most diseases, including diabetes, stem from abnormalities in the functioning of proteins, and some studies have reported the expression of protein variation to be involved in the development of DM1. Thus, the aim of this study was to investigate the differential expression of serum proteins in patients with DM1...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Zoltán Prohászka, Michael Kirschfink, Ashley Frazer-Abel
Complement immunobiology, and with it complement analysis, has undergone a renaissance in the past decade. Classically, complement analysis was limited number of testing C3, C4 in a routine laboratory with the possible addition of CH50 with all other analysis being performed at only few highly esoteric laboratories. This diagnostics expanding beyond specialized laboratories is the result of the growing recognition of the role played by complement dysfunction in many more diseases and disorders and the concomitant increase in interest in complement targeting therapeutics...
June 19, 2018: Molecular Immunology
Inka Liesmaa, Riitta Paakkanen, Asko Järvinen, Ville Valtonen, Marja-Liisa Lokki
INTRODUCTION: Homozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex. There are no studies where the clinical presentation of these patients is analyzed. This study was aimed to characterize the clinical features of patients with homozygous C4A or C4B deficiency. MATERIAL AND METHODS: Thirty-two patients with no functional C4A, 87 patients with no C4B and 120 with normal amount of C4 genes were included...
2018: PloS One
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