keyword
https://read.qxmd.com/read/38523687/high-level-of-serum-complement-c3-expression-is-associated-with-postoperative-vasculopathy-progression-in-moyamoya-disease
#1
JOURNAL ARTICLE
Min-Jie Wang, Jiayu Wang, Houdi Zhang, Fang-Bin Hao, Gan Gao, Si-Meng Liu, Xiao-Peng Wang, Jing-Jie Li, Zheng-Xing Zou, Qing-Bao Guo, He-Guan Fu, Yi-Qin Han, Cong Han, Lian Duan
BACKGROUND: The immune system plays an important role in the onset and development of moyamoya disease (MMD), but the specific mechanisms remain unclear. This study aimed to explore the relationship between the expression of complements and immunoglobulin in serum and progression of MMD. METHODS: A total of 84 patients with MMD and 70 healthy individuals were enrolled. Serum immunoglobulin and complement C3 and C4 expression were compared between healthy individuals and MMD patients...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38504252/soluble-periostin-is-a-potential-surveillance-biomarker-for-early-and-long-term-response-to-chemotherapy-in-advanced-breast-cancer
#2
JOURNAL ARTICLE
Li Jia, Wenwei Hu, Xu Yan, Jie Shao, Yuhong Guo, Aimin Zhang, Lianzi Yu, Yunli Zhou, Yueguo Li, Li Ren, Dong Dong
BACKGROUND: Noninvasive biomarkers for the assessment of response to chemotherapy in advanced breast cancer (BCa) are essential for optimized therapeutic decision-making. We evaluated the potential of soluble Periostin (POSTN) in circulation as a novel biomarker for chemotherapy efficacy monitoring. METHODS: Two hundred and thirty-one patients with different stages of BCa were included. Of those patients, 58 patients with inoperable metastatic disease receiving HER2-targeted or non-targeted chemotherapy were enrolled to assess the performances of markers in recapitulating the chemotherapy efficacy assessed by imaging...
March 19, 2024: Cancer Cell International
https://read.qxmd.com/read/38492120/cross-sectional-and-longitudinal-associations-between-metal-mixtures-and-serum-c3-c4-result-from-the-manganese%C3%A2-exposed-workers-healthy-cohort
#3
JOURNAL ARTICLE
Sencai Lin, Junxiu He, Yinghua Zhou, Yu Bao, Xiuming Feng, Hong Cheng, Haiqing Cai, Sihan Hu, Lin Wang, Yuan Zheng, Mengdi Zhang, Qinghua Fan, Shifeng Wen, Yuanxin Lin, Chaoqun Liu, Xing Chen, Fei Wang, Xiaoting Ge, Xiaobo Yang
Exposure to metal mixtures compromises the immune system, with the complement system connecting innate and adaptive immunity. Herein, we sought to explore the relationships between blood cell metal mixtures and the third and fourth components of serum complement (C3, C4). A total of 538 participants were recruited in November 2017, and 289 participants were followed up in November 2021. We conducted a cross-sectional analysis at baseline and a longitudinal analysis over 4 years. Least Absolute Shrinkage and Selection Operator (LASSO) was employed to identify the primary metals related to serum C3, C4; generalized linear model (GLM) was further used to evaluate the cross-sectional associations of the selected metals and serum C3, C4...
March 16, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38479932/changes-in-proteomic-cargo-of-circulating-extracellular-vesicles-in-response-to-lifestyle-intervention-in-adolescents-with-hepatic-steatosis
#4
JOURNAL ARTICLE
Johanna K DiStefano, Ignazio S Piras, Xiumei Wu, Ritin Sharma, Krystine Garcia-Mansfield, Maya Willey, Brooke Lovell, Patrick Pirrotte, Micah L Olson, Gabriel Q Shaibi
BACKGROUND: Recent studies suggest that proteomic cargo of extracellular vesicles (EVs) may play a role in metabolic improvements following lifestyle interventions. However, the relationship between changes in liver fat and circulating EV-derived protein cargo following intervention remains unexplored. METHODS: The study cohort comprised 18 Latino adolescents with obesity and hepatic steatosis (12 males/6 females; average age 13.3 ± 1.2 y) who underwent a six-month lifestyle intervention...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38479097/effects-of-dietary-artemisia-annua-supplementation-on-growth-performance-antioxidant-capacity-immune-function-and-gut-microbiota-of-geese
#5
JOURNAL ARTICLE
Yizhe Cui, Xinyang Leng, Yujie Zhao, Yu Zhao, Qiuju Wang
This experiment aimed to study the effect of 1% Artemisia annua added to the diet on growth performance, antioxidant capacity, immunity and intestinal morphology, and gut microbiota of geese. Seventy-two 35-day-old male geese (Zi goose) with similar body weight were selected and randomly divided into 2 groups. Each treatment group of 36 geese was divided into 6 subgroups, each having 6 male geese. The experiment lasted for 21 d. Control group (CON) was fed a basal diet and the experimental group (AAL) was fed a basal diet + 1% Artemisia annua...
February 28, 2024: Poultry Science
https://read.qxmd.com/read/38474267/role-of-advanced-glycation-end-products-as-new-biomarkers-in-systemic-lupus-erythematosus
#6
JOURNAL ARTICLE
Irene Carrión-Barberà, Laura Triginer, Laura Tío, Carolina Pérez-García, Anna Ribes, Victoria Abad, Ana Pros, Marcelino Bermúdez-López, Eva Castro-Boqué, Albert Lecube, José Manuel Valdivielso, Ilervas Project Group, Jordi Monfort, Tarek Carlos Salman-Monte
Advanced glycation end-products (AGEs) may play a relevant role as inducers in the chronic inflammatory pathway present in immune-mediated diseases, such as systemic lupus erythematosus (SLE). AGEs concentrations have been associated, with discrepant results to date, with some parameters such as disease activity or accrual damage, suggesting their potential usefulness as biomarkers of the disease. Our objectives are to confirm differences in AGEs levels measured by cutaneous autofluorescence between SLE patients and healthy controls (HC) and to study their correlation with various disease parameters...
March 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38465509/high-level-of-c3-is-associated-with-th2-immune-response-and-liver-fibrosis-in-patients-with-schistosomiasis
#7
JOURNAL ARTICLE
Xianmo Wang, Quan Gong, Hao Nie, Jiancheng Tu, Wen Fan, Xiaoping Tan
Long-term infection of schistosomiasis will seriously affect the liver health of patients. The serum of 334 chronic Schistosoma japonicum patients and 149 healthy volunteers was collected. Compared with heathy people, the level of C4 (complement 4) was increased, and the level of C3 (complement 3) was in an obvious skewed distribution. ELISA was performed to detect the serum cytokines, the results showed that the levels of IFN-γ (interferon-γ), IL (interleukin)-2 and TNF-α (tumour necrosis factor-α) were reduced, while the levels of Th2 cytokines (IL-4, IL-6 and IL-10) were increased...
March 2024: Parasite Immunology
https://read.qxmd.com/read/38451738/accurate-detection-of-convergent-mutations-in-large-protein-alignments-with-condor
#8
JOURNAL ARTICLE
Marie Morel, Anna Zhukova, Frédéric Lemoine, Olivier Gascuel
Evolutionary convergences are observed at all levels, from phenotype to DNA and protein sequences, and changes at these different levels tend to be correlated. Notably, convergent mutations can lead to convergent changes in phenotype, such as changes in metabolism, drug resistance, and other adaptations to changing environments. We propose a two-component approach to detect mutations subject to convergent evolution in protein alignments. The "Emergence" component selects mutations that emerge more often than expected, while the "Correlation" component selects mutations that correlate with the convergent phenotype under study...
March 7, 2024: Genome Biology and Evolution
https://read.qxmd.com/read/38440734/uncovering-lupus-nephritis-specific-genes-and-the-potential-of-tnfrsf17-targeted-immunotherapy-a-high-throughput-sequencing-study
#9
JOURNAL ARTICLE
Xiaojuan Zou, Mingyue Yang, Zhuang Ye, Tie Li, Zhenyu Jiang, Ying Xia, Shenghai Tan, Yu Long, Xiaosong Wang
INTRODUCTION: Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE). This study aimed to identify LN specific-genes and potential therapeutic targets. METHODS: We performed high-throughput transcriptome sequencing on peripheral blood mononuclear cells (PBMCs) from LN patients. Healthy individuals and SLE patients without LN were used as controls. To validate the sequencing results, qRT-PCR was performed for 5 upregulated and 5 downregulated genes...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38427745/direct-immunofluorescence-dif-versus-immunohistochemical-ihc-staining-of-complements-and-immunoglobulins-ig-in-pemphigus-group
#10
JOURNAL ARTICLE
Deepika Rana, Nita Khurana, Shramana Mandal, Bijay Laxmi Sahoo
INTRODUCTION: Pemphigus is a group of bullous disorders of the skin characterized by the formation of autoantibodies present in the intercellular junction of the epidermis. Diagnosis is made by clinical, histopathological examination, and DIF. As DIF needs frozen sections, fluorescent tagged antibodies, UV light microscope for examination, and trained personnel, its non-availability makes a definitive diagnosis challenging. AIMS AND OBJECTIVES: To evaluate the utility of IHC staining of complements and Ig in cases of Pemphigus...
February 19, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38404406/acquired-angioedema-associated-with-lymphoproliferative-disorders
#11
Jun Yen Ng, Meidelynn Ooi, Samuel K Bennett, Kirsty Rady, Philip Choi, Wei-I Lee, Matthew C Cook, Katrina L Randall, Nalini K Pati
INTRODUCTION: Acquired angioedema due to C1 esterase inhibitor deficiency (C1INH-AAE) is most associated with lymphoproliferative disorders (LPDs), particularly low-grade B-cell subtypes. The condition remains under-recognized with long diagnostic delays due to various challenges including a lack of awareness of the condition. CASE PRESENTATION: We discuss 4 cases of C1INH-AAE associated with low-grade B-cell LPDs, including various diagnostic and management challenges...
2024: Case Reports in Oncology
https://read.qxmd.com/read/38401513/uv-stimulated-riboflavin-exerts-immunosuppressive-effects-in-balb-c-mice-and-human-pbmcs
#12
JOURNAL ARTICLE
Xinghui Chen, Shuang Ge, Pan Xiao, Yulin Liu, Yang Yu, Yi Liu, Liping Sun, Lu Yang, Deqing Wang
Riboflavin (RF) as a photosensitizer has been used in corneal surgery and the inactivation of blood products. However, the effect of RF on immune cells after ultraviolet (UV) light stimulation has not been investigated. This study pioneered a novel application method of RF. Firstly, UV-stimulated RF was co-cultured with human peripheral blood mononuclear cells in vitro, and the apoptosis rate of lymphocyte subsets, cell proliferation inhibition rate and concentrations of IL-1β, IL-6, IL-10, TNF-α were assessed...
February 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38398562/reactivity-of-the-ethenium-cation-c-2-h-5-with-ethyne-c-2-h-2-a-combined-experimental-and-theoretical-study
#13
JOURNAL ARTICLE
Vincent Richardson, Miroslav Polášek, Claire Romanzin, Paolo Tosi, Roland Thissen, Christian Alcaraz, Ján Žabka, Daniela Ascenzi
The gas-phase reaction between the ethyl cation (C2 H5 + ) and ethyne (C2 H2 ) is re-investigated by measuring absolute reactive cross sections (CSs) and branching ratios (BRs) as a function of collision energy, in the thermal and hyperthermal energy range, via tandem-guided ion beam mass spectrometry under single collision conditions. Dissociative photoionization of C2 H5 Br using tuneable VUV radiation in the range 10.5-14.0 eV is employed to generate C2 H5 + , which has also allowed us to explore the impact of increasing (vibrational) excitation on the reactivity...
February 9, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38387189/renin-angiotensin-aldosterone-system-inhibitors-increase-the-serum-level-of-complement-component-4-in-patients-with-immunoglobulin-a-nephropathy
#14
JOURNAL ARTICLE
Min Mao, Yun Zhou, Xu Zhang, Xiao-Yu Zhao, Chen-Dan Wang, Ping Chen
OBJECTIVE: To investigate the impact of renin-angiotensin-aldosterone-system (RAAS) inhibitors on complement component 4 (C4) serum levels in patients with immunoglobulin A nephropathy (IgAN). METHODS: A total of 423 patients diagnosed with IgAN at Shanxi Provincial People's Hospital, China, between 1 January 2017 and 31 December 2021 were divided into two groups, a RAAS inhibitor group and a non-RAAS inhibitor group, for comparative analysis. RESULTS: The RAAS inhibitor group exhibited significantly increased C4 and eGFR levels and had a higher proportion of patients with hypertension compared with the non-RAAS inhibitor group...
February 21, 2024: International Immunopharmacology
https://read.qxmd.com/read/38383923/immunophenotyping-of-peripheral-blood-in-nsclc-patients-discriminates-responders-to-immune-checkpoint-inhibitors
#15
JOURNAL ARTICLE
Ludmila Krizova, Iva Benesova, Petra Zemanova, Jan Spacek, Zuzana Strizova, Zuzana Humlova, Veronika Mikulova, Lubos Petruzelka, Michal Vocka
PURPOSE: Immune checkpoint inhibitors (ICIs) dramatically changed the prognosis of patients with NSCLC. Unfortunately, a reliable predictive biomarker is still missing. Commonly used biomarkers, such as PD-L1, MSI, or TMB, are not quite accurate in predicting ICI efficacy. METHODS: In this prospective observational cohort study, we investigated the predictive role of erythrocytes, thrombocytes, innate and adaptive immune cells, complement proteins (C3, C4), and cytokines from peripheral blood of 224 patients with stage III/IV NSCLC treated with ICI alone (pembrolizumab, nivolumab, and atezolizumab) or in combination (nivolumab + ipilimumab) with chemotherapy...
February 21, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38374851/a-case-of-adult-onset-still-s-disease-with-hypocomplementemia
#16
Yoichi Kurosawa, Sayuri Takamura, Ayako Wakamatsu, Daisuke Kobayashi, Ichiei Narita
Adult-onset Still's disease (AOSD) causes fever, rash, pharyngalgia, and arthralgia through autoinflammation. Its complement titer has not previously received attention because this usually increases during the inflammatory process. Our female patient in her 60s was admitted to the hospital with fever, rash, arthralgia, and pharyngalgia. Her white blood cell count was 19,130/μL, hemoglobin was 11.0 g/dL, platelet count was 26.0 × 104 /μL, and ferritin titer was 6,175 ng/mL. Anti-nuclear antibodies and anti-neutrophil cytoplasmic antibodies were negative...
January 2024: Curēus
https://read.qxmd.com/read/38372634/molecular-interactions-required-for-activation-of-complement-component-c2-include-exosites-located-on-the-serine-protease-domain-of-c1s-and-mannose-binding-lectin-associated-protease-2
#17
JOURNAL ARTICLE
Lilian Hor, Jing Pan, Robert N Pike, Lakshmi C Wijeyewickrema
The activation of the CP/LP C3 proconvertase complex is a key event in complement activation and involves cleavage of C4 and C2 by the C1s protease (classical pathway) or the mannose-binding lectin-associated serine protease (MASP)-2 (lectin pathway). Efficient cleavage of C4 by C1s and MASP-2 involves exosites on the complement control protein and serine protease (SP) domains of the proteases. The complement control protein domain exosite is not involved in cleavage of C2 by the proteases, but the role of an anion-binding exosite (ABE) on the SP domains of the proteases has (to our knowledge) never been investigated...
February 19, 2024: Journal of Immunology
https://read.qxmd.com/read/38356686/anticardiolipin-antibody-plays-a-more-important-role-than-anti-%C3%AE-2-glycoprotein-i-antibody-in-activating-complement-in-patients-with-lupus-nephritis
#18
JOURNAL ARTICLE
Qiankun Zhang, Zhuoqin Ren, Jie Li, Zhengping Zou
OBJECTIVE: This research aimed to explore the correlation between antiphospholipid antibodies (aPLs) and complement activation in lupus nephritis (LN) patients. METHODS: A retrospective analysis was carried out on patients diagnosed with LN based on renal biopsy from June 2019 to June 2022. The study assessed levels of IgM, IgA, and IgG subtypes of anticardiolipin antibodies (aCLs) and anti-β2-glycoprotein I (anti-β2-GPI) antibodies. Pathological and clinical data were collected concurrently with the renal biopsy...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38349459/a-longitudinal-prospective-study-of-active-tuberculosis-in-a-western-europe-setting-insights-and-findings
#19
JOURNAL ARTICLE
Arantxa Romero-Tamarit, Xavier Vallès, María Munar-García, Juan Espinosa-Pereiro, Núria Saborit, Ma Teresa Tortola, Zoran Stojanovic, Sílvia Roure, Adrián Antuori, Pere-Joan Cardona, Antoni Soriano-Arandes, Andrea Martin-Nalda, María Espiau, Maria Luiza de Souza-Galvão, Ma Ángeles Jiménez, Antoni Noguera-Julian, Israel Molina, Xavier Casas, Marisol Domínguez-Álvarez, Neus Jové, Nino Gogichadze, Kaori L Fonseca, Lilibeth Arias, Joan-Pau Millet, Adrián Sánchez-Montalvá, Cristina Vilaplana
PURPOSE: This study investigates the potential of inflammatory parameters (IP), symptoms, and patient-related outcome measurements as biomarkers of severity and their ability to predict tuberculosis (TB) evolution. METHODS: People with TB were included prospectively in the Stage-TB study conducted at five clinical sites in Barcelona (Spain) between April 2018 and December 2021. Data on demographics, epidemiology, clinical features, microbiology, and Sanit George Respiratory Questionnaire (SGRQ) and Kessler-10 as Health-Related Quality of Life (HRQoL) were collected at three time points during treatment...
February 13, 2024: Infection
https://read.qxmd.com/read/38345968/patient-characteristics-associated-with-concurrent-klebsiella-pneumoniae-infection-and-severe-pulmonary-tuberculosis
#20
JOURNAL ARTICLE
Li-Jun Song, Jun-Ke Qiu, Xiao-Qing Huang, Lin Zhang, Deng-Zhu Wu
BACKGROUND: This study aims to investigate the clinical characteristics associated with concurrent Klebsiella pneu-moniae (K. pneumoniae) infection in hospitalized patients with severe pulmonary tuberculosis. METHODS: A retrospective study was conducted on hospitalized severe pulmonary tuberculosis patients between January 2019 and December 2020. Among the 487 patients with severe pulmonary tuberculosis, a positive sputum culture for K. pneumoniae was reported in 76 patients (15...
February 1, 2024: Clinical Laboratory
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