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JOURNAL ARTICLE
Marina Bambi, Giulio Galla, Claudio Donati, Francesco Rovero, Heidi C Hauffe, Claudia Barelli
Although male and female mammals differ in biological traits and functional needs, the contribution of this sexual dimorphism to variations in gut bacteria and fungi (gut microbiota) in relation to habitat type has not been fully examined. To understand whether the combination of sex and habitat affects gut microbiota variation, we analyzed 40 fecal samples of wild yellow baboons (Papio cynocephalus) living in contrasting habitat types (intact, well-protected vs. fragmented, less protected forests) in the Udzungwa Mountains of Tanzania...
January 9, 2024: Scientific Reports
#22
Andras Heczey, Xin Xu, Amy N Courtney, Gengwen Tian, Gabriel A Barragan, Linjie Guo, Claudia Martinez Amador, Nisha Ghatwai, Purva Rathi, Michael S Wood, Yanchuan Li, Chunchao Zhang, Thorsten Demberg, Erica J Di Pierro, Andrew C Sher, Huimin Zhang, Birju Mehta, Sachin G Thakkar, Bambi Grilley, Tao Wang, Brian D Weiss, Antonino Montalbano, Meena Subramaniam, Chenling Xu, Chirag Sachar, Daniel K Wells, Gianpietro Dotti, Leonid S Metelitsa
No abstract text is available yet for this article.
January 9, 2024: Nature Medicine
#23
JOURNAL ARTICLE
Chiraag D Kapadia, Gerardo Rosas, Sachin G Thakkar, Mengfen Wu, Virginia Torrano, Tao Wang, Bambi J Grilley, Helen E Heslop, Carlos A Ramos, Margaret A Goodell, Premal D Lulla
Chimeric antigen receptor (CAR) T-cells are an emerging therapy for refractory lymphomas. Clonal hematopoiesis (CH), the preferential outgrowth of mutated bone marrow progenitors, is enriched in lymphoma patients receiving CAR-T cells. CAR-T therapy requires conditioning chemotherapy and often induces systemic inflammatory reactions, both of which have been shown to promote expansion of CH clones. Thus, we hypothesized that pre-existing CH clones could expand during CAR-T cell treatment. We measured CH at 154 timepoints longitudinally sampled from 26 patients receiving CD30...
December 26, 2023: Cytotherapy
#24
JOURNAL ARTICLE
LaQuisa C Hill, Rayne H Rouce, Mengfen Wu, Tao Wang, Royce Ma, Huimin Zhang, Birju Mehta, Natalia Lapteva, Zhuyong Mei, Tyler S Smith, Lina Yang, Madhuwanti Srinivasan, Phillip M Burkhardt, Carlos A Ramos, Premal D Lulla, Martha Arredondo, Bambi Grilley, Helen E Heslop, Malcolm K Brenner, Maksim Mamonkin
Despite newer targeted therapies, patients with primary refractory or relapsed (r/r) T-cell lymphoma have a poor prognosis. Development of CAR-T cell platforms to treat T-cell malignancies often requires additional gene modification to overcome fratricide due to shared T-cell antigens on normal and malignant T-cells. We developed a CD5-directed CAR that produces minimal fratricide by downmodulating CD5 protein levels on transduced T-cells while retaining strong cytotoxicity against CD5 positive malignant cells...
December 25, 2023: Blood
#25
REVIEW
Xiaochang Chen, Jue Li, Aoqi Xiang, Hua Guan, Peihong Su, Lusha Zhang, Dian Zhang, Qi Yu
BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein, known as a pseudo-receptor for TGFβ, as, while its extracellular domain is similar to that of type I TGFβ receptors, its intracellular structure is shorter and lacks a serine/threonine phosphokinase signaling motif. BAMBI can regulate numerous biological phenomena, including glucose and lipid metabolism, inflammatory responses, and cell proliferation and differentiation. Furthermore, abnormal expression of BAMBI at the mRNA and protein levels contributes to various human pathologies, including obesity and cancer...
January 2024: Experimental and Therapeutic Medicine
#26
JOURNAL ARTICLE
Sean Sachdev
Radiation therapy (RT) remains one of the most effective and utilized oncologic treatments available. While it can directly yield tumor cell death, its impact on the immune microenvironment is more complex, promoting either an antitumor response or, conversely, a tumor-promoting state. TGF-β, induced by RT, yields a more immunosuppressive environment, including potentially blunting response to immune-checkpoint blockade. In this issue of the JCI, Wang and colleagues demonstrate that RT reduced expression of bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI), a TGF-β pseudoreceptor...
December 15, 2023: Journal of Clinical Investigation
#27
JOURNAL ARTICLE
Liangliang Wang, Wei Si, Xianbin Yu, Andras Piffko, Xiaoyang Dou, Xingchen Ding, Jason Bugno, Kaiting Yang, Chuangyu Wen, Linda Zhang, Dapeng Chen, Xiaona Huang, Jiaai Wang, Ainhoa Arina, Sean Pitroda, Steven J Chmura, Chuan He, Hua Laura Liang, Ralph Weichselbaum
Activation of TGF-β signaling serves as an extrinsic resistance mechanism that limits the potential for radiotherapy. Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) antagonizes TGF-β signaling and is implicated in cancer progression. However, the molecular mechanisms of BAMBI regulation in immune cells and its impact on antitumor immunity after radiation have not been established. Here, we show that ionizing radiation (IR) specifically reduces BAMBI expression in immunosuppressive myeloid-derived suppressor cells (MDSCs) in both murine models and humans...
December 15, 2023: Journal of Clinical Investigation
#28
Katya Giannios, Abhishek Chaurasia, Cecilia Bueno, Jessica L Riesterer, Lucas Pagano, Terence P Lo, Guillaume Thibault, Joe W Gray, Xubo Song, Bambi DeLaRosa
Machine learning approaches have the potential for meaningful impact in the biomedical field. However, there are often challenges unique to biomedical data that prohibits the adoption of these innovations. For example, limited data, data volatility, and data shifts all compromise model robustness and generalizability. Without proper tuning and data management, deploying machine learning models in the presence of unaccounted for corruptions leads to reduced or misleading performance. This study explores techniques to enhance model generalizability through iterative adjustments...
November 27, 2023: bioRxiv
#29
Shalini Singh, Leila B Giron, Maliha W Shaikh, Shivanjali Shankaran, Phillip A Engen, Zlata R Bogin, Simona A Bambi, Aaron R Goldman, Joao L L C Azevedo, Lorena Orgaz, Nuria de Pedro, Patricia González, Martin Giera, Aswin Verhoeven, Elena Sánchez-López, Ivona Vasile Pandrea, Toshitha Kannan, Ceylan E Tanes, Kyle Bittinger, Alan L Landay, Michael J Corley, Ali Keshavarzian, Mohamed Abdel-Mohsen
Background People with HIV (PWH), even with controlled viral replication through antiretroviral therapy (ART), experience persistent inflammation. This is partly due to intestinal microbial dysbiosis and translocation. Such ongoing inflammation may lead to the development of non-AIDS-related aging-associated comorbidities. However, there remains uncertainty regarding whether HIV affects the biological age of the intestines and whether microbial dysbiosis and translocation influence the biological aging process in PWH on ART...
October 30, 2023: Research Square
#30
REVIEW
Valentina Becherucci, Giacomo Maria Bacci, Elisa Marziali, Andrea Sodi, Franco Bambi, Roberto Caputo
Retinitis pigmentosa, defined more properly as cone-rod dystrophy, is a paradigm of inherited diffuse retinal dystrophies, one of the rare diseases with the highest prevalence in the worldwide population and one of the main causes of low vision in the pediatric and elderly age groups. Advancements in and the understanding of molecular biology and gene-editing technologies have raised interest in laying the foundation for new therapeutic strategies for rare diseases. As a consequence, new possibilities for clinicians and patients are arising due to the feasibility of treating such a devastating disorder, reducing its complications...
September 28, 2023: Biomedicines
#31
JOURNAL ARTICLE
Antonino Di Stefano, Umberto Rosani, Stefano Levra, Isabella Gnemmi, Paola Brun, Mauro Maniscalco, Silvestro Ennio D'Anna, Vitina Carriero, Francesca Bertolini, Fabio L M Ricciardolo
BACKGROUND: Bone morphogenic proteins (BMPs) and their antagonists are involved in the tissue development and homeostasis of various organs. OBJECTIVE: To determine transcriptomic and protein expression of BMPs and their antagonists in stable COPD. METHODS: We measured the expression and localization of BMPs and some relevant antagonists in bronchial biopsies of stable mild/moderate COPD (MCOPD) (n = 18), severe/very severe COPD (SCOPD) (n = 16), control smokers (CS) (n = 13), and control non-smokers (CNS) (n = 11), and in lung parenchyma of MCOPD (n = 9), CS (n = 11), and CNS (n = 9) using immunohistochemistry and transcriptome analysis, in vitro after the stimulation of the 16HBE cells...
October 3, 2023: Biology
#32
JOURNAL ARTICLE
Kristina Eisinger, Philipp Girke, Christa Buechler, Sabrina Krautbauer
Transforming growth factor beta (Tgfb) is a well-studied pro-fibrotic cytokine, which upregulates cellular communication network factor 2 (Ccn2), collagen, and actin alpha 2, smooth muscle (Acta2) expression. Obesity induces adipose tissue fibrosis, which contributes to metabolic diseases. This work aimed to analyze the expression of Tgfb, Ccn2, collagen1a1 (Col1a1), Acta2 and BMP and activin membrane-bound inhibitor (Bambi), which is a negative regulator of Tgfb signaling, in different adipose tissue depots of mice fed a standard chow, mice fed a high fat diet (HFD) and ob/ob mice...
October 26, 2023: Mammalian Genome: Official Journal of the International Mammalian Genome Society
#33
JOURNAL ARTICLE
Early myopericarditis diagnosed in a 31-year-old patient using smartwatch technology: A case report.
Samuele Diodato, Yari Bardacci, Khadija El Aoufy, Simone Belli, Stefano Bambi
INTRODUCTION: Smartwatches, wrist-mounted devices with computing capacity able to connect with other devices via short-range wireless networking, are today commonly used by the general population to monitor their health status using specific applications. Currently, these devices offer new possibilities in remote health care monitoring and integration with other applications, through alert notifications, collection of personal data by a variety of sensors and the storage of these data...
October 3, 2023: International Emergency Nursing
#34
JOURNAL ARTICLE
Samuele Baldassini Rodriguez, Yari Bardacci, Khadija El Aoufy, Marco Bazzini, Christian Caruso, Gian Domenico Giusti, Andrea Mezzetti, Alberto Lucchini, Pasquale Iozzo, Andrea Guazzini, Camilla Elena Magi, Paolo Iovino, Yari Longobucco, Laura Rasero, Stefano Bambi
INTRODUCTION: The COVID-19 pandemic has had a considerable impact on the psychological and psychopathological status of the population and health care workers in terms of insomnia, anxiety, depression, and post-traumatic stress disorder. The primary aim of this study was to describe and evaluate the impact of the pandemic on insomnia levels of a cohort of Italian nurses, particularly those involved in the care of COVID-19 patients. The secondary aim was to identify the interaction between insomnia and hardiness, anxiety, and sleep disturbances...
September 7, 2023: Nursing Reports
#35
JOURNAL ARTICLE
Marissa Lammon
The Walt Disney company has been the topic of extensive research for decades; among the explored subjects and identified themes is Disney's fixation on death. Disney has capitalized on the incredibly traumatic childhood experience of the death of a parent by featuring parental death as a major narrative component. Speculation remains regarding the accuracy of not only death presentations in media, but death influence on characters. Using textual analysis, this paper explores the role of parental death on child character development within two Disney animated films...
September 15, 2023: Omega
#36
REVIEW
Laura María Compañ-Gabucio, Carolina Ojeda-Belokon, Laura Torres-Collado, Manuela García-de-la-Hera
Eating is considered one of the activities of daily living most affected by autism spectrum disorder (ASD) in children and adolescents and, therefore, needs to be thoroughly assessed using specific tools. The aim of this scoping review was to describe the most widely used tool to assess diet in children and adolescents with ASD. A search was conducted on PubMed, Scopus, EMBASE, Web of Science and PsycINFO databases. Two authors screened the articles and included all randomized or non-randomized studies published in English or Spanish in the last five years in which the diet of children and adolescents with ASD was assessed...
August 27, 2023: Nutrients
#37
JOURNAL ARTICLE
Yuping Li, Mengdan Xu, Haiying Zhai, Changfu Yang, Jiaotong Yang, Zunli Ke, Wanhao Chen, Jiangqin Ou, Zongge Sha, Qiaoqiao Xiao
Pathological epithelial‑mesenchymal transition (EMT) has been shown to fulfill a key role in the development and progression of a variety of lung diseases. It has been demonstrated that the inflammatory microenvironment is a decisive factor in inducing pathological EMT. Hexacylated lipopolysaccharide (LPS) [or proacylated lipopolysaccharide (P‑LPS), which functions as proinflammatory lipopolysaccharide] is one of the most effective Toll‑like receptor 4 (TLR4) agonists. Furthermore, the pentacylated and tetracylated form of lipopolysaccharide (or A‑LPS, which functions as anti‑inflammatory lipopolysaccharide) has been shown to elicit competitive antagonistic effects against the pro‑inflammatory activity of P‑LPS...
October 2023: Molecular Medicine Reports
#38
JOURNAL ARTICLE
Sabrina Ehnert, Helen Rinderknecht, Chao Liu, Melanie Voss, Franziska M Konrad, Wiebke Eisler, Dorothea Alexander, Kristian-Christos Ngamsri, Tina Histing, Mika F Rollmann, Andreas K Nussler
Chronic wounds affect more than 2% of the population worldwide, with a significant burden on affected individuals, healthcare systems, and societies. A key regulator of the entire wound healing cascade is transforming growth factor beta (TGF-β), which regulates not only inflammation and extracellular matrix formation but also revascularization. This present work aimed at characterizing wound tissues obtained from acute and chronic wounds regarding angiogenesis, inflammation, as well as ECM formation and degradation, to identify common disturbances in the healing process...
August 18, 2023: Cells
#39
JOURNAL ARTICLE
Khadar Abdi, Eleri Adams, Sonika Agarwal, Mehmet Ali Ergun, Talal Altamimi, Arzu Aral, Hanifa Arfi, Eric Armour, Laura Armstrong, Sarah B Mulkey, Jephté Bambi, Luke Baxter, Eric Benner, Soume Bhattacharya, Thérèse Biselele, Hayrunnisa Bolay, Paula Camila Mayorga, Melisa Carrasco, Emma Carter, Agnes Chao, Amber Cooke, María Corsi-Cabrera, Lourdes Cubero-Rego, Deborah Cuddyer, Doctor Dawn Gano, María de Los Angeles Cubero-Rego, Sandrine de Ribaupierre, Alexander Drobyshevsky, Mohamed El-Dib, Zubeyir Elmazoglu, Lisa Emrick, Adrian Epstein, Carmna Erdei, Patricia Flynn, Emma Gail Duerden, Katherine Gibson, Simon Gregory, Elif Gulcicek Abbasoglu Topa, Muktar H Aliyu, Thalía Harmony, Jade Harshbarger, Caroline Hartley, Masahiro Hayakawa, Hasan Huseyin Kazan, Terrie Inder, Yuji Ito, Vaibhav Jain, Michael Jurkiewicz, Bhavya Kapoor, Lilian Kebaya, Elif Keles Gulnerman, Hiroyuki Kidokoro, Elizabeth Kling, Sumire Kumai, Djamil Lebane, Monica Lemmon, Hamisu M Salihu, Simon Marchant, Charles Maxfield, Gloire Mbayabo, Paige Meyerink, Ryan Millman, Takamasa Mitsumatsu, Tomohiko Nakata, Hajime Narita, Jun Natsume, Jessica Pacheco, Lindsay Pagano, Andrea Pardo, Colleen Peyton, Roberta Pineda, Shilpa Reddy, Josefina Ricardo-Garcell, Blaire Rikard, Sriya Roychaudhuri, Emily S Nichols, Iwona Sadowska-Krawczenko, Yoshiaki Sato, Fumi Sawamura, Mark Scher, Danielle Sharon, Yvonne Sheldon, Anna Shiraki, Elizabeth Singh, Tina Steele, Ryosuke Suzui, Bruno-Paul Tady, Gentaro Taga, Tomo Tarui, Noah Trapp, Leandro Tristao, Debola Tuka, Takafumi Ushida, Fatima Usman, Charu Venkatesan, Hama Watanabe, Agnieszka Witulska-Alagöz, Hiroyuki Yamamoto, Vasily Yarnykh, Noelle Younge
No abstract text is available yet for this article.
2023: Journal of Neonatal-perinatal Medicine
#40
JOURNAL ARTICLE
Yingru Zhi, Qingyuan Gao, Zhibing Wang, Yu Dong, Yue Guan, Jie Yuan, Zhenyu Zhang
Liver metastasis of colorectal cancer (CRC) is a major cause of cancer morbidity and mortality. Circular RNAs (circRNAs) have been widely reported to be implicated in cancer metastasis. This study aims to investigate the effect of circSP5 (has_circ_0057010) on liver metastasis of CRC. Quantitative real-time PCR (RT-qPCR) analysis was performed to detect gene expression. The level of proteins was measured by western blot. The migration and invasion of CRC cells were assessed by wound healing assay and transwell assay...
August 18, 2023: Functional & Integrative Genomics
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