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Andras Heczey, David Steffin, Nisha Ghatwai, Antonino Montalbano, Purva Rathi, Amy Courtney, Azlann Arnett, Julien Fleurence, Ramy Sweidan, Tao Wang, Huimin Zhang, Prakash Masand, John Maris, Dan Martinez, Jennier Pogoriler, Navin Varadarajan, Sachin Thakkar, Deborah Lyon, Natasha Lapteva, Mei Zhuyong, Kalyani Patel, Dolores Lopez-Terrada, Carlos Ramos, Premal Lulla, Tannaz Armaghany, Bambi Grilley, Gianpietro Dotti, Leonid Metelitsa, Helen Heslop, Malcolm Brenner, Pavel Sumazin
Interleukin-15 (IL15) promotes the survival of T lymphocytes and enhances the antitumor properties of CAR T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy1-4. Glypican-3 (GPC3) is expressed in a group of solid cancers5-10, and here we report the first evaluation in humans of the effects of IL15 co-expression on GPC3-CAR T cells. Cohort 1 patients (NCT02905188/NCT02932956) received GPC3-CAR T cells, which were safe but produced no objective antitumor responses and reached peak expansion at two weeks...
April 3, 2024: Research Square
#2
JOURNAL ARTICLE
Jingyang Chen, Tengdi Fan, Lingxiao Pan, Hanshi Yang
Osteosarcoma (OS), known for its high recurrence and metastasis rates, poses a significant challenge in oncology. Our research investigates the role of programmed cell death (PCD) genes in OS and develops a prognostic model using advanced bioinformatics. We analyzed single-cell sequencing data from the Gene Expression Omnibus (GEO) database to identify subpopulations, distinguish malignant from non-malignant cells, assess cell cycle phases, and map PCD gene distribution. Additionally, we applied consistency clustering to bulk sequencing data from GEO and TARGET (Therapeutically Applicable Research to Generate Effective Treatments) databases, facilitating survival analysis across clusters with the Kaplan-Meier method...
April 15, 2024: Environmental Toxicology
#3
JOURNAL ARTICLE
Ruigang Niu, Xiaojun Zhang, Yang Yu, Zhenning Bao, Junqing Yang, Jianbo Yuan, Fuhua Li
As one of the most important aquaculture species in the world, the improvement of growth traits of the Pacific white shrimp ( Litopenaeus vannamei ), has always been a primary focus. In this study, we conducted SNP-specific locus analysis and identified a growth-related gene, BAMBI , in L. vannamei . We analyzed the structure and function of LvBAMBI using genomic, transcriptomic, metabolomic, and RNA interference (RNAi) assays. The LvBAMBI possessed highly conserved structural domains and widely expressed in various tissues...
April 1, 2024: Animals: An Open Access Journal From MDPI
#4
JOURNAL ARTICLE
Camilla Elena Magi, Stefano Bambi, Laura Rasero, Yari Longobucco, Khadija El Aoufy, Carla Amato, Ercole Vellone, Guglielmo Bonaccorsi, Chiara Lorini, Paolo Iovino
Self-care plays a critical role in symptom recognition, management, and risk factor modification for patients with chronic illnesses. Despite its significance, self-care levels in this population are generally poor. Health literacy (HL) is pivotal for promoting effective self-care, yet the association across specific chronic illnesses remains fragmented and conflicting. Therefore, a systematic review and meta-analysis will be conducted. Inclusion criteria encompass quantitative studies involving adult patients with at least one chronic illness reporting on the association between a measure of HL and one or more elements of self-care behaviors as outcomes...
March 31, 2024: Healthcare (Basel, Switzerland)
#5
JOURNAL ARTICLE
M Giaccherini, M Rende, M Gentiluomo, C Corradi, L Archibugi, S Ermini, E Maiello, L Morelli, C H J van Eijck, G M Cavestro, M Schneider, A Mickevicius, K Adamonis, D Basso, V Hlavac, D Gioffreda, R Talar-Wojnarowska, B Schöttker, M Lovecek, G Vanella, M Gazouli, M Uno, E Malecka-Wojciesko, P Vodicka, M Goetz, M F Bijlsma, M C Petrone, F Bazzocchi, M Kiudelis, A Szentesi, S Carrara, G Nappo, H Brenner, A C Milanetto, P Soucek, V Katzke, G Peduzzi, C Rizzato, C Pasquali, X Chen, G Capurso, T Hackert, B Bueno-de-Mesquita, F G G Uzunoglu, P Hegyi, W Greenhalf, G E E Theodoropoulos, C Sperti, F Perri, M Oliverius, A Mambrini, F Tavano, R Farinella, P G Arcidiacono, M Lucchesi, S Bunduc, J Kupcinskas, G Di Franco, S Stocker, J P Neoptolemos, F Bambi, K Jamroziak, S G G Testoni, M N Aoki, B Mohelnikova-Duchonova, J R Izbicki, R Pezzilli, R T Lawlor, E F Kauffmann, E López de Maturana, N Malats, F Canzian, D Campa
Pleiotropic variants (i.e., genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted ten years ago in relation to pancreatic ductal adenocarcinoma susceptibility. However, in the last decade, genetic association studies performed on several human traits have greatly increased the number of known pleiotropic variants. Based on the hypothesis that variants already associated with a least one trait have a higher probability of association with other traits, 61,052 variants reported to be associated by at least one genome wide association study (GWAS) with at least one human trait were tested in the present study consisting of two phases (discovery and validation), comprising a total of 16,055 pancreatic ductal adenocarcinoma (PDAC) cases and 212,149 controls...
April 12, 2024: Mutagenesis
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REVIEW
Pasquale Iozzo, Noemi Spina, Giovanna Cannizzaro, Valentina Gambino, Agostina Patinella, Stefano Bambi, Ercole Vellone, Rosaria Alvaro, Roberto Latina
(1) Background: Older patients who attend emergency departments are frailer than younger patients and are at a high risk of adverse outcomes; (2) Methods: To conduct this systematic review, we adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines. We systematically searched literature from PubMed, Embase, OVID Medline® , Scopus, CINAHL via EBSCOHost, and the Cochrane Library up to May 2023, while for grey literature we used Google Scholar. No time restrictions were applied, and only articles published in English were included...
February 23, 2024: Journal of Clinical Medicine
#7
EDITORIAL
Alberto Lucchini, Pasquale Iozzo, Stefano Bambi
No abstract text is available yet for this article.
April 6, 2024: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
#8
JOURNAL ARTICLE
Stefano Bambi, Alberto Lucchini
The term "system well-being" can move forward a new vision, meaning the result coming from the addition of the well-being of persons belonging to different institutions and organizations, which are all parts of the "health care system." Beginning with this "new definition," with the aim of analyzing the multifaceted issues related to nurses' well-being, we could use the "classical nursing metaparadigm" composed of 4 concepts: "health," "nursing," "environment," and "person." We briefly describe this conceptual map and provide some focused suggestions for further reflection on topics such as physical and psychological well-being, economic gain and career opportunities, work climate, burnout, low job satisfaction, moral distress, compassion fatigue, and a joyful work environment...
May 2024: Dimensions of Critical Care Nursing: DCCN
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JOURNAL ARTICLE
Camilla Elena Magi, Laura Rasero, Edoardo Mannucci, Guglielmo Bonaccorsi, Francesco Ranaldi, Luigia Pazzagli, Paola Faraoni, Nadia Mulinacci, Stefano Bambi, Yari Longobucco, Ilaria Dicembrini, Paolo Iovino
AIMS: A systematic review and meta-analysis of published randomized controlled trials was conducted to collate evidence from studies implementing ancient grains and investigate the impact of ancient grain consumption on health outcomes of patients with Diabetes Mellitus (DM). DATA SYNTHESIS: Twenty-nine randomized controlled trials were included, and 13 were meta-analyzed. Interventions ranged from 1 day to 24 weeks; most samples were affected by DM type 2 (n = 28 studies) and the ancient grains used were oats (n = 10 studies), brown rice (n = 6 studies), buckwheat (n = 4 studies), chia (n = 3 studies), Job's Tears (n = 2 studies), and barley, Khorasan and millet (n = 1 study)...
March 7, 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#10
JOURNAL ARTICLE
Benjamin L Musher, Eric K Rowinsky, Brandon G Smaglo, Wasif Abidi, Mohamed Othman, Kalpesh Patel, Salmaan Jawaid, James Jing, Amanda Brisco, Ann M Leen, Mengfen Wu, Linda C Sandin, Jessica Wenthe, Emma Eriksson, Gustav J Ullenhag, Bambi Grilley, Justyna Leja-Jarblad, Susan G Hilsenbeck, Malcolm K Brenner, Angelica S I Loskog
BACKGROUND: Pancreatic ductal adenocarcinoma is characterised by low immunogenicity and an immunosuppressive tumour microenvironment. LOAd703, an oncolytic adenovirus with transgenes encoding TMZ-CD40L and 4-1BBL, lyses cancer cells selectively, activates cytotoxic T cells, and induces tumour regression in preclinical models. The aim of this study was to evaluate the safety and feasibility of combining LOAd703 with chemotherapy for advanced pancreatic ductal adenocarcinoma. METHODS: LOKON001 was a non-randomised, phase 1/2 study conducted at the Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA, and consisted of two arms conducted sequentially; the results of arm 1 are presented here...
April 2024: Lancet Oncology
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JOURNAL ARTICLE
Jean Baptiste Bernard Pea-Assounga, Hongxing Yao, Grace Mulindwa Bahizire, Prince Dorian Rivel Bambi, Jonathan Dior Nima Ngapey
This research suggests a study model of determinants of investment decisions in the context of financial innovation. The paper considers the technology innovation dimension, which influences stakeholders' (customer and employee) satisfaction, bank performance, and investment decisions. This research aims to bridge the gap by analyzing the effect of the innovation component, financial innovation on investment decisions and considering the mediated link via stakeholders' satisfaction and the bank's performance as well as the moderating role of Internet security (IS) and utilizing data gathered from 575 banks' employees and customers in Congo...
March 30, 2024: Heliyon
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JOURNAL ARTICLE
Khadija El Aoufy, Maria Ramona Melis, Paolo Iovino, Stefano Bambi, Chiara Lorini, Guglielmo Bonaccorsi, Ilaria Galetti, Carla Garbagnati, Paola Canziani, Silvia Tonolo, Marco Mitola, Serena Guiducci, Daniel E Furst, Marco Matucci-Cerinic, Laura Rasero, Silvia Bellando-Randone
RATIONALE AND AIM: Health literacy (HL) is pivotal for the successful self-management of chronic diseases. Little HL information is currently available in SSc patients; therefore, the present study aims at evaluating the HL levels in an Italian cohort of SSc patients. METHODS: SSc patients were enrolled with the support of Italian patient associations, from September 2022 to March 2023. Health literacy characteristics were derived from the Health Literacy Scale European Questionnaire-16 (HLS-EU-Q16), consisting of 16 items designed on a four-point Likert scale ranging from "very difficult" to "very easy", and three HL levels were identified: inadequate HL (0-8 score); problematic HL (9-12 score); and sufficient HL (13-16 score)...
March 5, 2024: Nursing Reports
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JOURNAL ARTICLE
Megan L Wenzell, Stormi L Pulver, Meara X H McMahon, Emily Kate Rubio, Scott Gillespie, Rashelle C Berry, Ivanna Betancourt, Bonnie Minter, Olivia Schneider, Chitra Yarasani, Destinee Rogers, Lawrence Scahill, Valerie Volkert, William G Sharp
OBJECTIVE: To examine clinical correlates and prevalence of food selectivity (FS) - ie, self-restricted diet, reluctance to try new foods - in children with autism spectrum disorder (ASD) ascertained from a general outpatient autism clinic. STUDY DESIGN: A multidisciplinary team (pediatric nurse practitioner, psychologist and dietitian) assessed medical and psychosocial histories and dietary habits in 103 children with ASD (mean age = 5.8 ± 2...
March 4, 2024: Journal of Pediatrics
#14
JOURNAL ARTICLE
Carmen M Lorente Flores, Zhuozhao Zhan, Anouk W J Scholten, Gerard J Hutten, Marieke Vervoorn, Hendrik J Niemarkt
AIM: The aim of our study was to investigate skin conditions when wearing and removing a novel wireless non-adhesive cardiorespiratory monitoring device for neonates (Bambi-Belt) compared to standard adhesive electrodes. STUDY DESIGN: This was a prospective study including preterm neonates requiring cardiorespiratory monitoring. Besides standard electrodes, the infants wore a Bambi Belt for 10 consecutive days. Their skin conditions were assessed using Trans Epidermal Water Loss (TEWL) and the Neonatal Skin Condition Score (NSCS) after daily belt and standard electrode removal...
February 16, 2024: Sensors
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JOURNAL ARTICLE
Shalini Singh, Leila B Giron, Maliha W Shaikh, Shivanjali Shankaran, Phillip A Engen, Zlata R Bogin, Simona A Bambi, Aaron R Goldman, Joao L L C Azevedo, Lorena Orgaz, Nuria de Pedro, Patricia González, Martin Giera, Aswin Verhoeven, Elena Sánchez-López, Ivona Pandrea, Toshitha Kannan, Ceylan E Tanes, Kyle Bittinger, Alan L Landay, Michael J Corley, Ali Keshavarzian, Mohamed Abdel-Mohsen
BACKGROUND: People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly attributed to intestinal microbial dysbiosis and translocation, which may lead to non-AIDS-related aging-associated comorbidities. The extent to which living with HIV - influenced by the infection itself, ART usage, sexual orientation, or other associated factors - affects the biological age of the intestines is unclear...
February 22, 2024: Microbiome
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JOURNAL ARTICLE
Rodolfo Tonin, Federica Feo, Silvia Falliano, Lorenzo Ferri, Laura Giunti, Martino Calamai, Elena Procopio, Francesco Mari, Valerio Conti, Ilaria Fanelli, Franco Bambi, Renzo Guerrini, Amelia Morrone
Congenital Disorders of Glycosylation (CDG) are rare inherited metabolic diseases caused by genetic defects in the glycosylation of proteins and lipids. In this study, we describe the generation and characterization of one human induced pluripotent stem cell (hiPSC) line from a 15-year-old male patient with CDG. The patient carried three variants, one (c.122G > A; p.Arg41Gln) inherited from his father and two (c.445 T > G; p.Leu149Arg and the novel c.980C > G; p.Thr327Arg) inherited from his mother in the ALG8 gene (OMIM #608103)...
December 2023: Stem Cell Research
#17
JOURNAL ARTICLE
Pelin Ünal, Ye Lu, Bas Bueno-de-Mesquita, Casper H J van Eijck, Renata Talar-Wojnarowska, Andrea Szentesi, Maria Gazouli, Edita Kreivenaite, Francesca Tavano, Ewa Małecka-Wojciesko, Bálint Erőss, Martin Oliverius, Stefania Bunduc, Mateus Nóbrega Aoki, Ludmila Vodickova, Ugo Boggi, Matteo Giaccherini, Jurate Kondrackiene, Roger Chammas, Orazio Palmieri, George E Theodoropoulos, Maarten F Bijlsma, Daniela Basso, Beatrice Mohelnikova-Duchonova, Pavel Soucek, Jakob R Izbicki, Vytautas Kiudelis, Giuseppe Vanella, Paolo Giorgio Arcidiacono, Barbara Włodarczyk, Thilo Hackert, Ben Schöttker, Faik G Uzunoglu, Franco Bambi, Mara Goetz, Viktor Hlavac, Hermann Brenner, Francesco Perri, Silvia Carrara, Stefano Landi, Péter Hegyi, Frederike Dijk, Evaristo Maiello, Giovanni Capretti, Sabrina Gloria Giulia Testoni, Maria Chiara Petrone, Hannah Stocker, Stefano Ermini, Livia Archibugi, Manuel Gentiluomo, Giulia Martina Cavestro, Raffaele Pezzilli, Gregorio Di Franco, Anna Caterina Milanetto, Cosimo Sperti, John P Neoptolemos, Luca Morelli, Klara Vokacova, Claudio Pasquali, Rita T Lawlor, Francesca Bazzocchi, Juozas Kupcinskas, Gabriele Capurso, Daniele Campa, Federico Canzian
Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict significance threshold commonly used makes it likely that many true risk loci are missed. Functional annotation of GWAS polymorphisms is a proven strategy to identify additional risk loci. We aimed to investigate single-nucleotide polymorphisms (SNP) in regulatory regions [transcription factor binding sites (TFBSs) and enhancers] that could change the expression profile of multiple genes they act upon and thereby modify PDAC risk...
February 2, 2024: Human Genomics
#18
JOURNAL ARTICLE
Hongliang Zhang, Xiaojie Wei, Shunyu Lu, Xing Lin, Jianchun Huang, Lixiu Chen, Xiang Huang, Luhui Jiang, Yuchun Li, Luhui Qin, Jinbin Wei, Renbin Huang
No abstract text is available yet for this article.
January 30, 2024: Biomedicine & Pharmacotherapy
#19
JOURNAL ARTICLE
Kimia Monshizadeh, Masoud Tajamolian, Fatemeh Anbari, Mohammad Yahya Vahidi Mehrjardi, Seyed Mehdi Kalantar, Mohammadreza Dehghani
BACKGROUND: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6-20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women...
January 18, 2024: BMC Medical Genomics
#20
JOURNAL ARTICLE
Sara Candidori, Nicolò Dozio, Kasra Osouli, Serena Graziosi, Alberto Antonio Zanini, Maria Laura Costantino, Francesco De Gaetano
Postpartum haemorrhage (PPH) is an obstetric emergency causing nearly one-quarter of maternal deaths worldwide, 99% of these in low-resource settings (LRSs). Uterine balloon tamponade (UBT) devices are a non-surgical treatment to stop PPH. In LRSs, low-cost versions of UBT devices are based on the condom balloon tamponade (CBT) technique, but their effectiveness is limited. This paper discusses the experimental study to assess the usability and performance of a medical device, BAMBI, designed as an alternative to current CBT devices...
January 13, 2024: Applied Ergonomics
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