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Daniele Campa, Martina Matarazzi, William Greenhalf, Maarten Bijlsma, Kai-Uwe Saum, Claudio Pasquali, Hanneke van Laarhoven, Andrea Szentesi, Francesca Federici, Pavel Vodicka, Niccola Funel, Raffaele Pezzilli, H Bas Bueno-de-Mesquita, Ludmila Vodickova, Daniela Basso, Ofure Obazee, Thilo Hackert, Pavel Soucek, Katarina Cuk, Jörg Kaiser, Cosimo Sperti, Martin Lovecek, Gabriele Capurso, Beatrice Mohelnikova-Duchonova, Kay-Tee Khaw, Anna-Katharina König, Juozas Kupcinskas, Rudolf Kaaks, Franco Bambi, Livia Archibugi, Andrea Mambrini, Giulia Martina Cavestro, Stefano Landi, Péter Hegyi, Jakob R Izbicki, Domenica Gioffreda, Carlo Federico Zambon, Francesca Tavano, Renata Talar-Wojnarowska, Krzysztof Jamroziak, Timothy J Key, Gianfranco Delle Fave, Oliver Strobel, Laimas Jonaitis, Angelo Andriulli, Rita T Lawlor, Felice Pirozzi, Verena Katzke, Chiara Valsuani, Yogesh K Vashist, Hermann Brenner, Federico Canzian
Telomere deregulation is a hallmark of cancer. Telomere length measured in lymphocytes (LTL) has been shown to be a risk marker for several cancers. For pancreatic ductal adenocarcinoma (PDAC) consensus is lacking whether risk is associated with long or short telomeres. Mendelian randomization approaches have shown that a score built from SNPs associated with LTL could be used as a robust risk marker. We explored this approach in a large scale study within the PANcreatic Disease ReseArch (PANDoRA) consortium...
October 16, 2018: International Journal of Cancer. Journal International du Cancer
Hong-Ju Liu, Gang Chen, Long Chen, Mei Zhou, Xian-Zhi Xiong, Zhao-Ji Meng, Sheng-Wen Sun, Xiao-Nan Tao
In CD4+ T helper (Th) cells, transforming growth factor β (TGF‑β) is indispensable for the induction of both regulatory T (Treg) and interleukin‑17‑producing effector T helper (Th17) cells. Although BMP and activin membrane‑bound inhibitor (BAMBI) is part of a rheostat‑like mechanism for the regulation of TGF‑β signalling and autoimmune arthritis in mouse models, the underlying activity of BAMBI on the human Th17/Treg cell axis, particularly during exposure to cigarette smoke, remains to be elucidated...
October 9, 2018: International Journal of Molecular Medicine
Carlos A Ramos, Rayne Rouce, Catherine S Robertson, Amy Reyna, Neeharika Narala, Gayatri Vyas, Birju Mehta, Huimin Zhang, Olga Dakhova, George Carrum, Rammurti T Kamble, Adrian P Gee, Zhuyong Mei, Meng-Fen Wu, Hao Liu, Bambi Grilley, Cliona M Rooney, Helen E Heslop, Malcolm K Brenner, Barbara Savoldo, Gianpietro Dotti
Second-generation (2G) chimeric antigen receptors (CARs) targeting CD19 are highly active against B cell malignancies, but it is unknown whether any of the costimulatory domains incorporated in the CAR have superior activity to others. Because CD28 and 4-1BB signaling activate different pathways, combining them in a single third-generation (3G) CAR may overcome the limitations of each individual costimulatory domain. We designed a clinical trial in which two autologous CD19-specific CAR-transduced T cell products (CD19...
September 13, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Michael A Motes, Jeffrey S Spence, Matthew R Brier, Hsueh-Sheng Chiang, Bambi L DeLaRosa, Justin Eroh, Mandy J Maguire, Raksha A Mudar, Gail D Tillman, Michael A Kraut, John Hart
To investigate differences in inhibitory control and processing speed over the life span, participants in 7- to 8-, 10- to 11-, 12- to 15-, 18- to 25-, and 54- to 80-year-old age cohorts completed a Go/No-Go task requiring varying levels of semantic categorization. Discriminant function analysis of correct rejection rates (CRRs), hit rates (HRs), and reaction times (RTs) revealed a function on which CRR loaded positively and RT loaded negatively, across categorization levels. Scores increased from youngest to the younger adult cohort and decreased for the older adult cohort...
October 4, 2018: Psychology and Aging
Alberto Lucchini, Stefano Bambi, Christian de Felippis, Alessandro Galazzi, Grazia Addis, Roberto Rona, Giacomo Grasselli, Antonio Pesenti, Roberto Fumagalli, Giuseppe Foti
INTRODUCTION: Oral care, using either a mouth rinse, gel, toothbrush, or combination of them, together with aspiration of secretions, may reduce the risk of ventilator-acquired pneumonia in intubated patents. Oral care procedure in patients on venovenous extracorporeal membrane oxygenation (VV-ECMO) may cause bleeding due to the systemic anticoagulation required. PURPOSE: The aim of this study was to investigate the rate of bleeding episodes during oral care in patients supported by VV-ECMO...
November 2018: Dimensions of Critical Care Nursing: DCCN
Lauren P McLaughlin, Rayne Rouce, Stephen Gottschalk, Vicky Torrano, George Carrum, Meng-Fen Wu, Fahmida Hoq, Bambi Grilley, Andrea M Marcogliese, Patrick J Hanley, Adrian P Gee, Malcolm K Brenner, Cliona M Rooney, Helen E Heslop, Catherine M Bollard
Autologous T cells targeting Epstein Barr virus (EBV) latent membrane proteins (LMPs) have shown safety and efficacy for the treatment of patients with type II latency EBV-associated lymphomas who have failed standard therapies, including high dose chemotherapy followed by autologous stem cell rescue. However, the safety and efficacy of allogeneic donor-derived LMP-specific T cells (LMP-Ts) have not been established for patients who have received allogeneic HSCT. Thus, we evaluated the safety and efficacy of donor-derived LMP-Ts in 26 patients who had received an allogeneic hematopoietic stem cell transplant (HSCT) for EBV-associated T/NK or B cell lymphomas (NCT00062868, NCT01956084; ClinicalTrials...
September 27, 2018: Blood
Paulo Muntu Bunga, Jephté Bambi Nzita, Gerry Mubungu, Sophie Nyembo Mangaza, Nono Joelle Seudjip, Michel Ntetani Aloni
Alchornea cordifolia is known to be a plant with a variety of medicinal properties and is quoted by many traditional healers to treat a variety of medicinal problems in the Democratic Republic of Congo. However, very little is known about its potential toxicity. We report the case of a 9-year-old boy referred for assessment of suspected bronchial troubles without a history of atopic disease or drug allergy who developed dyspnea, dysphagia, asthenia and lingual ulcers within 30 minutes after nasal and oral administration of decoction of palm oil associated with A...
September 26, 2018: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
Fengsong Liu, Kai Wang, Liang Zhang, Ya-Lin Yang
Bone cancer is one of the most common tumor types that occurs in bones and their affiliated tissues. The prognosis remains poor due to the limited number of effective therapeutic targets. Downregulation of bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) has been observed in human cancer cells and BAMBI reconstitution can inhibit growth and metastasis of human cancer cells. In the present study, a potential mechanism mediated by BAMBI in osteosarcoma cells was investigated. The data demonstrated that BAMBI reconstitution suppressed the cell growth, migration and invasion of the osteosarcoma cell lines SAOS2 and MG63...
October 2018: Oncology Letters
Flaminia Chellini, Alessia Tani, Larissa Vallone, Daniele Nosi, Paola Pavan, Franco Bambi, Sandra Zecchi Orlandini, Chiara Sassoli
The antifibrotic potential of platelet-rich plasma (PRP) is controversial. This study examined the effects of PRP on in vitro transforming growth factor (TGF)-β1-induced differentiation of fibroblasts into myofibroblasts, the main drivers of fibrosis, and the involvement of vascular endothelial growth factor (VEGF)-A in mediating PRP-induced responses. The impact of PRP alone on fibroblast differentiation was also assessed. Myofibroblastic phenotype was evaluated by confocal fluorescence microscopy and western blotting analyses of α-smooth muscle actin (sma) and type-1 collagen expression, vinculin-rich focal adhesion clustering, and stress fiber assembly...
September 19, 2018: Cells
Diptadip Dattaroy, Ratanesh Kumar Seth, Sutapa Sarkar, Diana Kimono, Muayad Albadrani, Varun Chandrashekaran, Firas Al Hasson, Udai P Singh, Ratanesh Kumar Seth, Erica Scappinie, Jeff C Tucker, Daping Fan, Mitzi Nagarkatti, Prakash Nagarkatti, Anna Mae Diehl, Saurabh Chatterjee
SsnB previously showed a promising role to lessen liver inflammation observed in a mouse model of NAFLD. Since NAFLD can progress to fibrosis, studies were designed to unravel its role in attenuating NAFLD associated fibrosis. Using both in vivo and in vitro approaches, the study probed the possible mechanisms that underline the role of SSnB in mitigating fibrosis. Mechanistically, SsnB, a TLR4 antagonist, decreased TLR4-PI3k akt signaling by upregulating PTEN protein expression. It also decreased MDM2 protein activation and increased p53 and p21 gene and protein expression...
September 5, 2018: European Journal of Pharmacology
Eissa I Fawzy, Aida I El Makawy, M Mahmoud El-Bamby, H Osama Elhamalawy
The present study was conducted to evaluate the ameliorative role of pumpkin seed oil (PSO) against potential adverse effects of bisphenol-A (BPA) in male mice. BPA was administered to the mice orally at a dose of 50 mg/kg body weight once a day for 28 successive days. While, PSO was administered to the mice orally at 1 mL/kg b w either before, with or after treatment of BPA, once a day for 28 successive days. The studied parameters were DNA damage evaluation using comet assay in liver and testes cells and micronucleus test in bone marrow; and histopathological examination of liver and testes tissues...
2018: Toxicology Reports
Christopher Ziemba, Odile Larivé, Eva Reynaert, Eberhard Morgenroth
On-site biological hand washing water treatment can improve global access to safe hand washing water, but requires a thorough understanding of the chemical composition of the water to be treated, and an effective treatment strategy. This study first presents a detailed characterization of the individual inputs to hand washing water. We demonstrate (i) that soap is likely the most significant input in hand washing water, representing ∼90% of mass loading, and (ii) that inputs to hand washing water have low concentrations of biologically-essential macro- and micro-nutrients (nitrogen, phosphorus, potassium, copper, zinc, molybdenum and cobalt) with respect to carbon, which may impair biological carbon removal...
November 1, 2018: Water Research
Le Tao, Dongying Xue, Dongxiao Shen, Wenting Ma, Jie Zhang, Xuefei Wang, Wei Zhang, Liu Wu, Kai Pan, Yanqin Yang, Zeribe C Nwosu, Steven Dooley, Ekihiro Seki, Cheng Liu
MicroRNA (miRNA)-mediated gene regulation contributes to liver pathophysiology, including hepatic stellate cell (HSC) activation and fibrosis progression. Here, we investigated the role of miR-942 in human liver fibrosis. The expression of miR-942, HSC activation markers, transforming growth factor-beta pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI), as well as collagen deposition, were investigated in 100 liver specimens from patients with varying degree of hepatitis B virus (HBV)-related fibrosis...
September 2018: Archives of Toxicology
Mónica Tramullas, Raquel Francés, Roberto de la Fuente, Sara Velategui, María Carcelén, Raquel García, Javier Llorca, María A Hurlé
Neuropathic pain is a debilitating chronic syndrome that is often refractory to currently available analgesics. Aberrant expression of several microRNAs (miRNAs) in nociception-related neural structures is associated with neuropathic pain in rodent models. We have exploited the antiallodynic phenotype of mice lacking the bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI), a transforming growth factor-β (TGF-β) pseudoreceptor. We used these mice to identify new miRNAs that might be useful for diagnosing, treating, or predicting neuropathic pain...
August 8, 2018: Science Translational Medicine
Chiara Campo, Aleksandra Köhler, Gisella Figlioli, Rossella Elisei, Cristina Romei, Monica Cipollini, Franco Bambi, Kari Hemminki, Federica Gemignani, Stefano Landi, Asta Försti
[This corrects the article DOI: 10.1371/journal.pone.0174995.].
2018: PloS One
Stefano Bambi, Chiara Foà, Christian De Felippis, Alberto Lucchini, Andrea Guazzini, Laura Rasero
BACKGROUND: Negative interactions among nurses are well recognized and reported in scientific literature, even because the issues may have major consequences on professional and private lives of the victims. The aim of this paper is to detect specifically the prevalence of workplace incivility (WI), lateral violence (LV) and bullying among nurses. Furthermore, it addresses the potential related factors and their impact on the psychological and professional spheres of the victims. METHODS: A review of the literature was performed through the research of papers on three databases: Medline, CINAHL, and Embase...
July 18, 2018: Acta Bio-medica: Atenei Parmensis
Francesco Lupariello, Serena Maria Curti, Elena Coppo, Sara Simona Racalbuto, Giancarlo Di Vella
The "Blue Whale Challenge" is a dangerous Internet phenomenon. As per media reports, it involves a series of life-threatening tasks imposed by a "curator" to "players," who must fulfill the whole list, and it ends with the suicide of the player. The authors report the data of five suspected cases of "Blue Whales" managed from January 2016 to December 2017 by the staff of a unit (the "Bambi Unit" of the Pediatric Hospital "Regina Margherita" of Turin, Italy) that is dedicated to the evaluation of suspected abused children...
July 23, 2018: Journal of Forensic Sciences
Leonel Maldonado, Mariana Brait, Evgeny Izumchenko, Shahnaz Begum, Aditi Chatterjee, Tanusree Sen, Myriam Loyo, Alvaro Barbosa, Maria Luana Poeta, Eugene Makarev, Alex Zhavoronkov, Vito M Fazio, Roberto Angioli, Carla Rabitti, Mate Ongenaert, Wim Van Criekinge, Maartje G Noordhuis, Pauline de Graeff, G Bea A Wisman, Ate G J van der Zee, Mohammad O Hoque
Many epigenetically inactivated genes involved in ovarian cancer (OC) development and progression remain to be identified. In this study we undertook an integrated approach that consisted of identification of genome-wide expression patterns of primary OC samples and normal ovarian surface epithelium along with a pharmacologic unmasking strategy using 3 OC and 3 immortalized normal ovarian epithelial cell lines. Our filtering scheme identified 43 OC specific methylated genes and among the 5 top candidates (GULP1, CLIP4, BAMBI, NT5E, TGFβ2), we performed extended studies of GULP1...
October 1, 2018: Cancer Letters
Diefei Liang, Zijiao Song, Weiwen Liang, Yan Li, Shanying Liu
AIMS: Metformin is a biguanide derivative widely used for the treatment of type 2 diabetes mellitus. Recent evidence implicates that this anti-hyperglycemic drug exerts renal protective effects, yet the mechanisms remain poorly understood. MCP-1 has been recognized as a key mediator of renal fibrosis in chronic kidney diseases including diabetic nephropathy. This study aimed to investigate the effects of metformin on TGF-β1-induced MCP-1 expression and the underlying mechanisms in rat renal tubular epithelial cells...
June 22, 2018: Nephrology
Sheng-Min Guo, Jian-Xiong Wang, Jin Li, Fang-Yuan Xu, Quan Wei, Hai-Ming Wang, Hou-Qiang Huang, Si-Lin Zheng, Yu-Jie Xie, Chi Zhang
Osteoarthritis (OA) significantly influences the quality life of people around the world. It is urgent to find an effective way to understand the genetic etiology of OA. We used weighted gene coexpression network analysis (WGCNA) to explore the key genes involved in the subchondral bone pathological process of OA. Fifty gene expression profiles of GSE51588 were downloaded from the Gene Expression Omnibus database. The OA-associated genes and gene ontologies were acquired from JuniorDoc. Weighted gene coexpression network analysis was used to find disease-related networks based on 21756 gene expression correlation coefficients, hub-genes with the highest connectivity in each module were selected, and the correlation between module eigengene and clinical traits was calculated...
June 15, 2018: Journal of Cellular Biochemistry
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