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https://www.readbyqxmd.com/read/30335006/aminoglycoside-associated-nonsyndromic-deafness-and-speech-disorder-in-mitochondrial-a1555g-mutation-in-a-family-a-case-report
#1
Yang-Hao Ou, Andy Wei-Ge Chen, Jun-Yang Fan, Wen-Ling Cheng, Ta-Tsung Lin, Mu-Kuan Chen, Chin-San Liu
RATIONALE: Mitochondrial DNA mutations have been associated with many maternal inherited diseases. A1555G mutation in mtDNA effects the gene code for rRNA, resulting in the structural change of human ribosome rending it susceptible to binding of the common antibiotic, aminoglycosides. Such mutation has linked with non-syndromic hearing loss and is one of the most common mtDNA mutations in Asian populations. PATIENT CONCERNS: A 50-year-old Taiwanese female visited our neurology department with concern for multiple members with hearing loss in her family, including herself...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30333968/biocl-decorated-nanbo-3-nanocubes-a-novel-p-n-heterojunction-photocatalyst-with-improved-activity-for-ofloxacin-degradation
#2
Jingjing Xu, Bingbing Feng, Ying Wang, Yadi Qi, Junfeng Niu, Mindong Chen
BiOCl/NaNbO3 p-n heterojunction photocatalysts with significantly improved photocatalytic performance were fabricated by a facile in-situ growth method. The obtained BiOCl/NaNbO3 samples were characterized by UV-vis absorption spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), photocurrent (PC) and photoluminescence spectroscopy (PL). The photocatalytic activity of the BiOCl/NaNbO3 samples was investigated by the degradation of a typical antibiotic Ofloxacin (OFX). The experimental results showed that BiOCl/NaNbO3 composites exhibited much higher photocatalytic activity for OFX degradation compared to pure NaNbO3 and BiOCl...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/30333934/practical-strategies-for-management-of-lenalidomide-associated-cytopenias-in-myelodysplastic-syndromes-with-del-5q
#3
REVIEW
Sandra E Kurtin, Jean A Ridgeway, Sara Tinsley
CASE STUDY A male patient aged 67 years with a 2-year history of refractory anemia and myelodysplastic syndromes (MDS) with del(5q) started lenalidomide (Revlimid) treatment as a participant in the MDS-001 trial (List et al., 2005). At the time of the study, this patient had been transfusion-dependent since 2001, and at study entry he had received a total of 12 units of red blood cells (RBCs). The patient started lenalidomide at 25 mg daily for 21 days of each 28-day cycle on April 2, 2002. (Please note that as a result of subsequent trials, the approved starting dose for lenalidomide in patients with del[5q] MDS is 10 mg...
November 2017: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/30332675/predictors-of-outcomes-in-patients-with-prolonged-weaning-with-focus-on-respiratory-tract-pathogens-and-infection
#4
Catharina Hommelsheim, Mathias Sichau, Roland Heipel, Eckhard Müller, Sören Gatermann, Michael Pfeifer, Santiago Ewig
BACKGROUND: The impact of respiratory tract pathogens and infection on outcomes in patients with prolonged weaning is largely unknown. OBJECTIVE: We studied predictors of weaning outcomes (death and failure to achieve spontaneous ventilation) in a population treated during a 3.5-year period in a specialized and certified weaning centre. METHODS: Patient data were retrieved retrospectively from the clinical charts. Complete datasets were available in 173 patients...
October 17, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/30332616/determination-of-live-dead-bacteria-as-a-function-of-antibiotic-treatment
#5
Runze Li, Dinesh Dhankhar, Jie Chen, Thomas C Cesario, Peter M Rentzepis
Antibiotics are drugs that react against, kill, or inhibit the growth of bacteria. The method most often employed to evaluate the effectiveness of an antibiotic to kill bacteria requires at least 16 to 24 h for bacterial incubation. The requirement of long periods of time for the determination of the number of bacteria still alive after antibiotic treatment, may, in many cases, be detrimental to the patient's health. In addition, with increasing of bacterial antibiotic resistance, the need to utilize methods for distinguishing between live and dead bacteria within a short period of time after treatment with antibiotic agents, is becoming more crucial...
October 14, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/30329228/-current-status-of-probiotics-usage-for-the-prevention-of-a-first-episode-of-clostridium-difficile-infection
#6
Chloé Cantero, Jacques Schrenzel, Pauline Darbellay Farhoumand
Antibiotics are among the most prescribed medications worldwide and they may cause an imbalance of the gut microbiota. At the same time, the incidence of Clostridium difficile diarrhea is increasing, with significant morbidity and mortality. Probiotics are living microorganisms, bacteria or yeasts, claimed to provide health benefits when ingested in sufficient quantity. Restoration of the gut microbiota has been evaluated as a means of preventing Clostridium difficile infection. The purpose of this article is to review the most recent evidence regarding the use of probiotics in the prevention of a first episode of Clostridium difficile infection among adult patients...
October 17, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/30328925/clinical-epidemiological-and-etiological-profile-of-inpatients-with-community-acquired-pneumonia-in-a-public-hospital-in-the-interior-of-brazil
#7
Laura Fuchs Bahlis, Luciano Passamani Diogo, Ricardo de Souza Kuchenbecker, Sandra Costa Fuchs
OBJECTIVE: To describe the patient profile, mortality rates, the accuracy of prognostic scores, and mortality-associated factors in patients with community-acquired pneumonia (CAP) in a general hospital in Brazil. METHODS: This was a cohort study involving patients with a clinical and laboratory diagnosis of CAP and requiring admission to a public hospital in the interior of Brazil between March 2014 and April 2015. We performed multivariate analysis using a Poisson regression model with robust variance to identify factors associated with in-hospital mortality...
July 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/30328745/isolation-of-fully-vancomycin-resistant-streptococcus-thoraltensis-from-the-nasal-cavity-of-a-healthy-young-adult
#8
Mohammad Al-Tamimi, Nisreen Himsawi, Jumana Abu-Raideh, Deaa Abu Jazar, Hussam Al-Jawaldeh
BACKGROUND: Streptococcus thoraltensis was first isolated from pigs and rabbits. Later, isolation from human oral and nasal cavities and from throat and oropharynx was documented. S. thoraltensis was isolated from patients with periodontitis, tonsillopharyngitis, and chorioamnionitis suggesting a possible pathological role in human infections. All S. thoraltensis isolates of animal and human origins were sensitive to vancomycin. METHODS: Standard microbiological identification methods, biochemical analysis, and antibiotic susceptibility testing using disk diffusion and E methods were used...
October 17, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30327780/screening-potential-probiotic-characteristics-of-lactobacillus-brevis-strains-in-vitro-and-intervention-effect-on-type-i-diabetes-in-vivo
#9
Amro Abdelazez, Heba Abdelmotaal, Smith Etareri Evivie, Sherif Melak, Fang-Fang Jia, Mir Hassan Khoso, Zong-Tao Zhu, Lu-Ji Zhang, Rokayya Sami, Xiang-Chen Meng
Diabetes has become the third most serious threat to human health, after cancer and cardiovascular disease. Notably, Lactobacillus brevis is the most common species of LAB that produces γ -aminobutyric acid (GABA). The aim of this study is to clarify the effect of time, strain types, antibiotic concentrations, different levels of pH, and intestinal juices in aerobic or anaerobic conditions and the effect of interactions between these factors on the potential properties of KLDS 1.0727 and KLDS 1.0373, furthermore, antagonistic activity against foodborne pathogens...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30327640/interplay-between-the-phenotype-and-genotype-and-efflux-pumps-in-drug-resistant-strains-of-riemerella-anatipestifer
#10
Qiwei Chen, Xiaowei Gong, Fuying Zheng, Guo Ji, Shengdou Li, Laszlo Stipkovits, Susan Szathmary, Yongsheng Liu
The number of multidrug-resistant strains of Riemerella anatipestifer continues to increase, and new strategies for the treatment of associated infections are necessary. Recently, numerous studies have shown that efflux pumps (EPs) play key roles in universal bacterial mechanisms that contribute to antibiotic resistance. In addition, studies have shown that the effects of antibiotics that are subjected to efflux can be reinforced by their combined use with efflux pump inhibitors (EPIs). Unfortunately, the role of the efflux system in R...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30327437/protection-against-staphylococcus-aureus-colonization-and-infection-by-b-and-t-cell-mediated-mechanisms
#11
Fan Zhang, Olivia Ledue, Maria Jun, Cibelly Goulart, Richard Malley, Ying-Jie Lu
Staphylococcus aureus is a major cause of morbidity and mortality worldwide. S. aureus colonizes 20 to 80% of humans at any one time and causes a variety of illnesses. Strains that are resistant to common antibiotics further complicate management. S. aureus vaccine development has been unsuccessful so far, largely due to the incomplete understanding of the mechanisms of protection against this pathogen. Here, we studied the role of different aspects of adaptive immunity induced by an S. aureus vaccine in protection against S...
October 16, 2018: MBio
https://www.readbyqxmd.com/read/30326954/probiotic-supplementation-restores-normal-microbiota-composition-and-function-in-antibiotic-treated-and-in-caesarean-born-infants
#12
Katri Korpela, Anne Salonen, Outi Vepsäläinen, Marjo Suomalainen, Carolin Kolmeder, Markku Varjosalo, Sini Miettinen, Kaarina Kukkonen, Erkki Savilahti, Mikael Kuitunen, Willem M de Vos
BACKGROUND: Infants born by caesarean section or receiving antibiotics are at increased risk of developing metabolic, inflammatory and immunological diseases, potentially due to disruption of normal gut microbiota at a critical developmental time window. We investigated whether probiotic supplementation could ameliorate the effects of antibiotic use or caesarean birth on infant microbiota in a double blind, placebo-controlled randomized clinical trial. Mothers were given a multispecies probiotic, consisting of Bifidobacterium breve Bb99 (Bp99 2 × 108 cfu) Propionibacterium freundenreichii subsp...
October 16, 2018: Microbiome
https://www.readbyqxmd.com/read/30326891/the-impact-of-prescriptions-audit-and-feedback-for-antibiotic-use-in-rural-clinics-interrupted-time-series-with-segmented-regression-analysis
#13
Li Zhen, Chenggang Jin, Hao-Nan Xu
BACKGROUND: Problems of irrational antibiotic use by prescribers are ongoing and have escalated following reductions in the cost of essential drugs policy. In an attempt to improve prescribing practices for village doctors and rational use of essential drugs, a program designed to audit and monitor drug use was established. However, the effects of the program to control antibiotic resistance and changing the village doctors' prescribing behaviors remain largely unknown. This study measured the effect of the program on levels of antibiotic use...
October 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/30326685/treatment-strategy-and-outcomes-in-patients-with-hematogenous-culture-negative-pyogenic-vertebral-osteomyelitis
#14
Gouse Mohamad, Rohit Amritanand, Kenny Samuel David, Venkatesh Krishnan, Justin Arockiaraj
Study Design: Retrospective case series. Purpose: The aim of this study was to analyze functional and radiological outcomes in patients with culture-negative pyogenic vertebral osteomyelitis (PVO). Overview of Literature: There were only few literature available for these group of patients. Methods: Patients with biopsy-positive but culture-negative PVO were included. We analyzed records for data on demography, comorbidities, coexisting infections, neurological status, prior antibiotic therapy, pre- and postoperative erythrocyte sedimentation rate, C-reactive protein levels, and Oswestry Disability Index, and Japanese Orthopedics Association scores...
October 18, 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/30326177/relation-between-broiler-and-human-c-jejuni-strains-isolated-in-belgium-from-2011-to-2013
#15
Alexandra Duarte, Nadine Botteldoorn, William G Miller, Wim Coucke, Delphine Martiny, Marie Hallin, Tomasz Seliwiorstow, Lieven De Zutter, Mieke Uyttendaele, Olivier Vandenberg, Katelijne Dierick
AIMS: This study inquires the relationship between Campylobacter jejuni isolated from broiler meat carcasses (n=97) and human clinical samples (n=72) in Belgium, from 2011 to 2013. METHODS AND RESULTS: The evaluation of the relation was based on the characteristics determined using multi-locus sequence typing (MLST) alone and combined with flagellin gene A restriction fragment length polymorphism (flaA-RFLP) typing, antibiotic microbiological resistance profiling (AMRp), lipooligosaccharide (LOS) class typing or virulence gene profiling (Vp)...
October 16, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/30325977/evaluation-of-clinical-outcomes-of-sutureless-vs-sutured-closure-techniques-in-gastroschisis-repair
#16
Russell G Witt, Michael Zobel, Benjamin Padilla, Hanmin Lee, Tippi C MacKenzie, Lan Vu
Importance: Sutureless gastroschisis repair offers an alternative to the traditional sutured method and has been associated with decreased intubation time. Published study results are inconsistent regarding the advantages of sutureless closure. Objective: To compare the clinical outcomes of sutureless and sutured gastroschisis repair. Design, Setting, and Participants: A single-center cohort review was performed of all consecutive patients (n = 97) who underwent gastroschisis repair from February 1, 2007, to April 30, 2017, at the University of California, San Francisco...
September 19, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/30325851/use-of-chlorhexidine-to-prevent-ventilator-associated-pneumonia-in-a-long-term-care-setting-a-retrospective-medical-record-review
#17
Margaret K McCue, Glen A Palmer
BACKGROUND: The purpose of this study was to explore the use of the oral decontamination solution chlorhexidine (CHX) to reduce ventilator-associated pneumonia (VAP) in a long-term ventilator care setting over time. Most of the research in this area has been conducted in acute and intensive care settings. METHODS: This study was a retrospective medical record review conducted in a long-term care facility with a dedicated ventilator unit. Veterans records (N = 12) were accessed for this study...
October 15, 2018: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/30325301/efficacy-of-%C3%AE-phenylethylamine-as-a-novel-anti-microbial-and-application-as-a-liquid-catheter-flush
#18
Meredith Schroeder, Shelley M Horne, Birgit M Prüß
With this study, we introduce a liquid flush for catheters and other tubing-based applications that consists of a solution of β-phenylethylamine (PEA) in tryptic soy broth. The initial experiments in multiwell polystyrene plates were conducted with Escherichia coli K-12 to assess the effectiveness of PEA at reducing planktonic growth, as well as the biomass and adenosine triphosphate (ATP) content of biofilm; PEA reduced these growth parameters as a function of increasing concentration. This effect was also seen in mutants of PEA catabolism, which leads us to believe that the PEA effect is due to PEA itself and not one of its degradation products...
October 16, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/30325073/vancomycin-elution-kinetics-from-porous-tantalum-metal
#19
Pierre Sautet, Thibaut Mékidèche, Romain Guilhaumou, Matthew P Abdel, Jean-Noël Argenson, Sébastien Parratte, Matthieu Ollivier
Revisions TKAs are being completed with uncemented constructs more frequently. We hypothesized that tantalum cones could be an efficient carrier of antibiotics in uncemented procedures. We aimed to compare the release of vancomycin between 1) tantalum and smooth stainless cylinders, 2) different concentrations of vancomycin and 3) different durations of bathing. Specifically designed tantalum cylinders were bathed in a vancomycin solution with various durations of baths. We investigated rinses between each interval as well as the dose of vancomycin...
October 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30324753/when-does-vesicoureteral-reflux-in-pediatric-kidney-transplant-patients-need-treatment
#20
Hsi-Yang Wu, Waldo Concepcion, Paul C Grimm
PURPOSE: The treatment of VUR in children with UTI has changed significantly, due to studies showing that antibiotic prophylaxis does not decrease renal scarring. As children with kidney transplants are at higher risk for UTI, we investigated if select patients with renal transplant VUR could be managed without surgery. MATERIALS AND METHODS: A total of 18 patients with VUR into their renal grafts were identified, and 319 patients underwent transplantation from 2006 to 2016...
October 15, 2018: Pediatric Transplantation
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