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https://www.readbyqxmd.com/read/30113467/bacteriuria-and-asymptomatic-infection-in-chronic-patients-with-indwelling-urinary-catheter-the-incidence-of-esbl-bacteria
#1
Sorin Albu, Septimiu Voidazan, Doina Bilca, Monica Badiu, Andreea Truţă, Marian Ciorea, Alin Ichim, Diana Luca, Geanina Moldovan
Urinary tract infections due to the presence of a urinary catheter represent a real problem for patients who have to carry such an invasive device for a long time.Our aim was to identify the susceptibility of extended spectrum beta lactamases (ESBL) versus non-ESBL bacteria to antibiotics in urinary tract infections in patients who are chronic carriers of urinary catheters.The retrospective study included a period of 5 years, a total of 405 patients who are chronic carriers of urinary catheters, admitted to rehabilitation and palliative care units...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30113370/translational-sepsis-research-spanning-the-divide
#2
Anthony J Lewis, Janet S Lee, Matthew R Rosengart
OBJECTIVE: Our knowledge of the molecular mechanisms of sepsis has attained exponential growth. Yet, the pillars of its care remain antibiotics, fluid resuscitation, and physiologic support of failing organ systems. The inability to bring biologic breakthroughs to the bedside is not for lack of effort. Over 60 clinical trials of novel therapies, each heavily supported by the momentum of biologic data suggesting clinical utility, have been conducted and have failed to identify benefit...
September 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/30113210/dietary-supplementation-with-ferric-tyrosine-improves-zootechnical-performance-and-reduces-caecal-campylobacter-spp-load-in-broilers
#3
D Currie, M Green, O A Dufailu, P Matthaios, P Soultanas, E McCartney, H Lester, Liza Van den Eede, J Apajalahti, J Mahdavi
The objective of this study was to evaluate the effect of ferric tyrosine on the reduction of Campylobacter spp. and zootechnical performance in broilers exposed to Campylobacter spp. using a natural challenge model to simulate commercial conditions. Additionally, the minimum inhibitory concentrations (MIC) of ferric tyrosine against common enteropathogens were evaluated. At the start of the trial, 840 healthy male one-day-old birds (Ross 308) were randomly allocated to six replicate pens of 35 birds each and fed diets containing different concentrations of ferric tyrosine (0, 0...
August 16, 2018: British Poultry Science
https://www.readbyqxmd.com/read/30112981/uk-trial-of-the-osseointegrated-prosthesis-for-the-rehabilitation-for-amputees-1995-2018
#4
Douglas John Matthews, Mateen Arastu, Maggie Uden, John Paul Sullivan, Kristina Bolsakova, Kingsley Robinson, Sellaiah Sooriakumaran, David Ward
BACKGROUND: Amputation of a limb impacts on patients' self-perception and quality of life. Prostheses directly anchored to the skeleton are being investigated, aiming to avoid soft tissue complications. OBJECTIVES: We report outcome data for the UK trial of the Osseointegrated Prosthesis for the Rehabilitation of Amputees Implant System with a minimum of 9-year follow-up. METHODS: Eighteen transfemoral amputees received unilateral implants between 1997 and 2008...
August 16, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/30112169/ozone-therapy-in-conjunction-with-oral-antibiotics-as-a-successful-primary-and-sole-treatment-for-chronic-septic-prosthetic-joint-review-and-case-report
#5
Robert Jay Rowen
The world is facing crisis in management of infectious diseases. The mainstay of treatment has been chemical anti-infectives. These drugs are failing, as superbugs emerge and medicine becomes more sophisticated with treatments such as prosthetic devices, which can harbor bacteria protected by biofilm. This case report describes a 68-year-old woman who received bilateral artificial hips on October 27, 2015. The right hip prosthesis subsequently became septic by June 2016. Three orthopedic surgeons offered her a several month program, which included removal of the prosthesis, implantation of an antibiotic impregnated "spacer" and months of intravenous antibiotics...
April 2018: Medical Gas Research
https://www.readbyqxmd.com/read/30111925/resurgence-of-global-opportunistic-multidrug-resistant-stenotrophomonas-maltophilia
#6
Pradheer Gupta, Pratibha Kale, Vikas Khillan
Context: Stenotrophomonas maltophilia is a known nosocomial pathogen which is intrinsically resistant to multiple antibiotics. In India, S. maltophilia infection has only few case reports. Aim: To determine the incidence of S. maltophilia infection from clinical isolates based on the specimen type, antibiotic susceptibility pattern, and impact on outcome. Settings and Design: One-year retrospective study was done at a tertiary liver care center...
July 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/30111627/aminoglycoside-heteroresistance-in-acinetobacter-baumannii-ab5075
#7
Sarah E Anderson, Edgar X Sherman, David S Weiss, Philip N Rather
Heteroresistance is a phenomenon where a subpopulation of cells exhibits higher levels of antibiotic resistance than the general population. Analysis of tobramycin resistance in Acinetobacter baumannii AB5075 using Etest strips demonstrated that colonies with increased resistance arose at high frequency within the zone of growth inhibition. The presence of a resistant subpopulation was confirmed by population analysis profiling (PAP). The tobramycin-resistant subpopulation was cross resistant to gentamicin but not amikacin...
August 15, 2018: MSphere
https://www.readbyqxmd.com/read/30110918/where-did-they-come-from-multi-drug-resistant-pathogenic-escherichia-coli-in-a-cemetery-environment
#8
Akebe Luther King Abia, Eunice Ubomba-Jaswa, Chantelle Schmidt, Matthys Alois Dippenaar
Human burial in cemeteries facilitates the decomposition of corpses without posing a public health danger. However, the role of cemeteries as potential environmental reservoirs of drug-resistant pathogens has not been studied. Thus, we investigated cemeteries as potential environmental reservoirs of multi-drug resistant (MDR) pathogenic Escherichia coli . E. coli isolates were obtained from water samples (collected from surface water bodies and boreholes in three cemeteries) after isolation using the Colilert® 18 system...
August 14, 2018: Antibiotics
https://www.readbyqxmd.com/read/30110916/hjh-1-a-broad-spectrum-antimicrobial-activity-and-low-cytotoxicity-antimicrobial-peptide
#9
Qing Wang, Yanzhao Xu, Mengmeng Dong, Bolin Hang, Yawei Sun, Lei Wang, Yongqiang Wang, Jianhe Hu, Wenju Zhang
With the overuse of antibiotics, multidrug-resistant bacteria pose a significant threat to human health. Antimicrobial peptides (AMPs) are a promising alternative to conventional antibiotics. This study examines the antimicrobial and membrane activity of HJH-1, a cationic peptide derived from the hemoglobin α-subunit of bovine erythrocytes P3. HJH-1 shows potent antimicrobial activity against different bacterial species associated with infection and causes weaker hemolysis of erythrocytes, at least five times the minimum inhibitory concentration (MIC)...
August 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30109686/removal-mechanism-of-sulfamethazine-and-its-intermediates-from-water-by-a-rotating-advanced-oxidation-contactor-equipped-with-tio-2-high-silica-zeolite-composite-sheets
#10
Shuji Fukahori, Misaki Ito, Taku Fujiwara
The removal of antibiotic sulfamethazine (SMT) and its intermediates from water was investigated using a rotating advanced oxidation contactor (RAOC) equipped with TiO2 -high-silica zeolite composite sheets. SMT was readily removed from water through adsorption onto high-silica zeolite and photocatalytic decomposition by TiO2 inside the composite sheet. Some degradation intermediates were retained and photocatalytically decomposed inside the composite sheet. Relatively hydrophobic intermediates such as hydroxylated SMT were captured inside the sheets, whereas hydrophilic intermediates were distributed in water...
August 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30108657/combination-of-epicatechin-3-gallate-from-euphorbia-hirta-and-cefepime-promotes-potential-synergistic-eradication-action-against-resistant-clinical-isolate-of-pseudomonas-aeruginosa
#11
Shanmugapriya Perumal, Roziahanim Mahmud, Nornisah Mohamed
Pseudomonas aeruginosa is naturally resistant to many classes of antipseudomonal antibiotics due to the species ability to easily acquire resistance. Plant-based antibacterial agent in combination with the existing antibiotic proposes an alternative treatment regimen for the eradication of resistant bacterial infections. The antibacterial effects of the isolated epicatechin 3-gallate compound from Euphorbia hirta in combination with cefepime were investigated in vitro against resistant P. aeruginosa . The fractional inhibitory concentration index of the combination was determined using checkerboard broth microdilution method...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30108117/epstein-barr-positive-classical-hodgkin-lymphoma-associated-haemophagocytic-lymphohistocytiosis-a-rare-case
#12
Alfredo Iardino, Zain Amar, Yasir Ahmed
Haemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition, which is usually triggered by autoimmune disorders, viral infections and malignancy, like lymphomas. We present a 60-year-old Hispanic woman with a medical history of hypertension and systemic lupus erythematosus presenting with fever, generalised weakness and shortness of breath for 3 weeks. She was hypotensive on presentation, and a CT scan of abdomen/chest showed multiple irregular hepatic and splenic hypodense lesions. A liver biopsy revealed Classical Hodgkin lymphoma (cHL) with positive Epstein-Barr virus (EBV) staining that was later confirmed with high serum EBV DNA levels...
August 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30108072/conservative-therapy-for-appendicitis-in-children
#13
Syunsuke Yamanaka, Erik D Skarsgard, Ran D Goldman
Question A 10-year-old girl who was seen in my office last week with acute-onset abdominal pain and fever was referred to an emergency department, was diagnosed with appendicitis, and was treated conservatively with antibiotics, without surgery. Has the paradigm for treating appendicitis changed, and which is the preferred treatment of appendicitis in children: antibiotics or appendectomy? Answer For more than 100 years, surgical management was the principal treatment of acute appendicitis. Potential adverse events associated with appendectomy include bleeding, surgical site infection, and ileus, as well as stress for children and their parents...
August 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/30107967/point-of-care-influenza-testing-does-not-significantly-shorten-time-to-disposition-among-patients-with-an-influenza-like-illness
#14
Elissa M Schechter-Perkins, Patricia M Mitchell, Kerrie P Nelson, James H Liu, Angela Shannon, Jean Ahern, Beverley Orr, Nancy S Miller
INTRODUCTION: Availability of anti-viral agents and need to isolate infected patients increases the need to confirm the diagnosis of influenza before determining patient disposition. OBJECTIVES: We sought to determine if time-to-disposition (TTD) was shorter among patients tested for influenza using an Emergency Department (ED) Point-of-care (POC) test compared to core laboratory (lab) test and to determine difference in antibiotic use between groups. METHODS: We prospectively enrolled a convenience sample of ED patients for whom influenza testing was ordered during influenza season 2017...
August 7, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30107778/real-time-monitoring-of-pseudomonas-aeruginosa-biofilm-formation-on-endotracheal-tubes-in-vitro
#15
Eva Pericolini, Bruna Colombari, Gianmarco Ferretti, Ramona Iseppi, Andrea Ardizzoni, Massimo Girardis, Arianna Sala, Samuele Peppoloni, Elisabetta Blasi
BACKGROUND: Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for both acute and chronic infections in humans. In particular, its ability to form biofilm, on biotic and abiotic surfaces, makes it particularly resistant to host's immune defenses and current antibiotic therapies as well. Innovative antimicrobial materials, like hydrogel, silver salts or nanoparticles have been used to cover new generation catheters with promising results. Nevertheless, biofilm remains a major health problem...
August 14, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/30107493/facelift-performed-safely-under-local-anesthesia-with-oral-sedation-analysis-of-174-patients
#16
Gianfranco Frojo, Aaron Dotson, Kara Christopher, Sumesh Kaswan, Herluf Lund
Background: Anesthesia for elective ambulatory procedures must provide appropriate pain control while minimizing perioperative risk. Local anesthesia in combination with oral sedation provides a safe office-based method of anesthesia for rhytidectomy. Objectives: The purpose of this analysis was to identify the incidence of traditional outcome parameters in ambulatory rhytidectomy performed with local anesthesia and oral sedation. Methods: A retrospective chart review was performed on all patients who underwent office-based rhytidectomy under local anesthesia with oral sedation from February 2011 to May 2017...
August 13, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/30107400/optimizing-the-design-and-analysis-of-clinical-trials-for-antibacterials-against-multidrug-resistant-organisms-a-white-paper-from-combacte-s-stat-net
#17
Marlieke E A de Kraker, Harriet Sommer, Femke de Velde, Isaac Gravestock, Emmanuel Weiss, Alexandra McAleenan, Stavros Nikolakopoulos, Ohad Amit, Teri Ashton, Jan Beyersmann, Leonhard Held, Andrew M Lovering, Alasdair P MacGowan, Johan W Mouton, Jean-François Timsit, David Wilson, Martin Wolkewitz, Esther Bettiol, Aaron Dane, Stephan Harbarth
Innovations are urgently required for clinical development of antibacterials against multidrug-resistant organisms. Therefore, a European, public-private working group (STAT-Net; part of Combatting Bacterial Resistance in Europe [COMBACTE]), has reviewed and tested several innovative trials designs and analytical methods for randomized clinical trials, which has resulted in 8 recommendations. The first 3 focus on pharmacokinetic and pharmacodynamic modeling, emphasizing the pertinence of population-based pharmacokinetic models, regulatory procedures for the reassessment of old antibiotics, and rigorous quality improvement...
August 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30107276/cpc-loaded-with-10-vcm-delivering-high-early-and-late-local-antibiotic-concentration-in-vitro
#18
Gaoyang Chen, Bo Liu, He Liu, Hanyang Zhang, Kerong Yang, Qingyu Wang, Jianxun Ding, Fei Chang
BACKGROUND: Antibiotics impregnated calcium phosphate cement (CPC) has emerged as a local treatment of osteomyelitis. However, there is no study investigating the optimal concentrations of vancomycin (VCM) included in CPC to obtain prolonged drug release (≥8 weeks) and also with enough compressive strength (>the normal cancellous bone, 11 MPa) for osteomyelitis therapy. Therefore, we bring forward two questions: 1) Was antibiotic activity of the eluates correlated to the load of antibiotics within the cement? 2) Were the mechanical properties of CPC affected by VCM-loading? Hypothesized: There was an optimal concentrations of vancomycin (VCM) loaded in CPC which could provide sufficient effective antibacterial time (≥8 weeks) and enough compressive strength (>11 MPa)...
August 11, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/30107036/ultrasound-assisted-synthesis-of-ag-zns-rgo-and-its-utilization-in-photocatalytic-degradation-of-tetracycline-under-visible-light-irradiation
#19
Samaneh Kameli, Ali Mehrizad
Recent improvements based on heterojunction nanocomposites have opened new possibilities in photocatalysis. In this research, an ultrasound assisted co-precipitation method was used to fabricate silver, zinc sulfide, and reduced graphene oxide (Ag-ZnS/rGO) nanocomposite, and characterization results indicated that 3% Ag-ZnS spherical nanoparticles are successfully embedded in rGO matrix. The potential of the Ag-ZnS/rGO, as a visible light active photocatalyst, was assessed through optimizing degradation of Tetracycline (TC) by response surface methodology...
August 14, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/30106964/administration-of-intravenous-antibiotics-in-patients-with-open-fractures-is-dependent-on-emergency-room-triaging
#20
Katharine D Harper, Courtney Quinn, Joshua Eccles, Frederick Ramsey, Saqib Rehman
BACKGROUND: Recent literature has demonstrated that emergent administration of antibiotics is perhaps more critical than even emergent debridement. Most recent studies recommend patients receive antibiotics no later than 1 hour after injury to prevent infection. The objective of this study is to evaluate the time to antibiotic administration after patients with open fractures arrive to a trauma center depending on triaging team. METHODS: A retrospective study at a level 1 Trauma center from January 2013 to March 2015 where 117 patients with open fractures were evaluated...
2018: PloS One
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