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Holding chamber

Oana Mirea, Mihaela Berceanu, Ionuț Donoiu, Constantin Militaru, Adrian Săftoiu, Octavian Istrătoaie
OBJECTIVES: We evaluated intra-observer, test-retest, and inter-observer reproducibility of right ventricular (RV) longitudinal strain (LS) measurements derived from two-dimensional speckle tracking echocardiography. BACKGROUND: The assessment of RV deformation has demonstrated to hold valuable prognostic and diagnostic data in clinical practice. Data about the reproducibility of the measurements, however, are missing. METHODS: In 200 subjects, apical modified four-chamber view focused on the right ventricle (RV) was obtained...
December 1, 2018: Echocardiography
Akira Kobayashi, Hideaki Yokogawa, Natsuko Mori, Toshinori Masaki, Kazuhisa Sugiyama
Purpose: To report a modified surgical technique called the "donor tissue holding technique for Descemet's membrane endothelial keratoplasty (DMEK)" using a newly developed 25-gauge graft manipulator. Methods: Six consecutive patients exhibiting endothelial dysfunction were enrolled and treated by DMEK. In brief, after insertion of a DMEK donor into the anterior chamber, the edge of the roll was grasped using a graft manipulator and this grasp was maintained throughout the centering and opening of the roll (holding technique)...
September 2018: Case Reports in Ophthalmology
Tara M Finegan, Daxiang Na, Christian Cammarota, Austin V Skeeters, Tamás J Nádasi, Nicole S Dawney, Alexander G Fletcher, Patrick W Oakes, Dan T Bergstralh
We investigated the cell behaviors that drive morphogenesis of the Drosophila follicular epithelium during expansion and elongation of early-stage egg chambers. We found that cell division is not required for elongation of the early follicular epithelium, but drives the tissue toward optimal geometric packing. We examined the orientation of cell divisions with respect to the planar tissue axis and found a bias toward the primary direction of tissue expansion. However, interphase cell shapes demonstrate the opposite bias...
November 26, 2018: EMBO Journal
Roberta Visone, Giuseppe Talò, Silvia Lopa, Marco Rasponi, Matteo Moretti
Tissue engineering strategies have been extensively exploited to generate functional cardiac patches. To maintain cardiac functionality in vitro, bioreactors have been designed to provide perfusion and electrical stimulation, alone or combined. However, due to several design limitations the integration of optical systems to assess cardiac maturation level is still missing within these platforms. Here we present a bioreactor culture chamber that provides 3D cardiac constructs with a bidirectional interstitial perfusion and biomimetic electrical stimulation, allowing direct cellular optical monitoring and contractility test...
November 16, 2018: Scientific Reports
Simon Tang, James Otton, Lois Holloway, Geoffrey P Delaney, Gary Liney, Armia George, Michael Jameson, David Tran, Vikneswary Batumalai, Liza Thomas, Eng-Siew Koh
PURPOSE: Subacute changes following breast radiotherapy have been demonstrated in discrete areas of the left ventricle (LV), with recent guidelines being developed to help determine dose to subvolumes of the LV. This study aims to determine doses to the 17 segments of the LV as per the American Heart Association (AHA) and other cardiac subvolumes, and to correlate mean heart (MHD) dose with various subvolume dosimetric indices. These results may direct focus to specific left ventricular segments in studies of radiation-related heart disease incorporating surveillance imaging, help to determine more precise dose response relationships, and potentially aid prediction of late radiation effects...
November 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Mrinalini Mishra, Chia-Yen Chan, Chi-Chung Kei, Yin-Cheng Yen, Ming-Wei Liao, Tsong-Pyng Perng
The effectiveness of three different designs of conduit plates was verified for even distribution of precursors in a voluminous forced-flow atomic layer deposition (ALD) chamber designed to hold macroscopic elongated substrates vertically. Furthermore, a new "soak function" was introduced in the controlling software of the ALD instrument. This function enabled increase in residence time of the precursor in the chamber without escalating the dosage. The flow of precursors guided by the conduit plates with and without application of the soak function was simulated using computational fluid dynamics...
October 2018: Review of Scientific Instruments
V E Fatherley, D N Fittinghoff, R L Hibbard, H J Jorgenson, J I Martinez, J A Oertel, D W Schmidt, C S Waltz, C H Wilde, P L Volegov
The current construction of a new nuclear-imaging view at the National Ignition Facility will provide a third line of sight for hotspot and cold fuel imaging and the first dedicated line of sight for 4.4-MeV γ-ray imaging of the remaining carbon ablator. To minimize the effort required to hold and align apertures inside the vacuum chamber, the apertures for the two lines of sight will be contained in the same array. In this work, we discuss the system requirements for neutron and γ-ray imaging and the resulting aperture array design...
October 2018: Review of Scientific Instruments
G Palacios-Serrano, F Hannon, C Hernandez-Garcia, M Poelker, H Baumgart
Nuclear physics experiments performed at the Continuous Electron Beam Accelerator Facility (CEBAF) at the Jefferson Lab require a DC high voltage photogun to generate polarized electron beams from GaAs photocathodes. The photogun uses a tapered ceramic insulator that extends into the vacuum chamber and mechanically holds the cathode electrode. Increasing the operating voltage from nominal -130 kV to -200 kV will provide lower beam emittance, better transmission through injector apertures, and improved photocathode lifetime...
October 2018: Review of Scientific Instruments
Marco Bastos, Dan Mercea, Andrea Baronchelli
This study explores the geographic dependencies of echo-chamber communication on Twitter during the Brexit campaign. We review the evidence positing that online interactions lead to filter bubbles to test whether echo chambers are restricted to online patterns of interaction or are associated with physical, in-person interaction. We identify the location of users, estimate their partisan affiliation, and finally calculate the distance between sender and receiver of @-mentions and retweets. We show that polarized online echo-chambers map onto geographically situated social networks...
2018: PloS One
Jochen D Schipke, Lars Eichhorn, Patrick Behm, Sinclair Cleveland, Malte Kelm, Florian Boenner
BACKGROUND: Breath-hold diving has increasingly established itself within the leisure sector as near-natural sport. In parallel, a number of competitive disciplines have developed. To reach greater depths various breathing maneuvers are employed one of them being glossopharyngeal insufflation (GI), for which air is repetitively "pumped" into the lungs in order to increase the intrathoracic air volume. As intrapulmonary pressure is considerable increased in parallel, venous return is impeded, leading to incomplete filling of the cardiac chambers...
October 30, 2018: Scandinavian Journal of Medicine & Science in Sports
Andrew Barton, Keith Pamment, Dennis Fitzpatrick
Implanted intravenous ports (IPs) are increasingly used in health care. The experience of having IPs accessed can vary a great deal for patients. Successful IP access depends on the experience and skill of the health professional and wrongly positioned attempts are not only painful for the patient but can also cause damage to the outer casing of the IP. The more skin punctures made over the port, the higher the risk of infection in the subcutaneous tissue. The Portacator is a sterile, single-use product that sits on the skin over the IP insertion site...
October 18, 2018: British Journal of Nursing: BJN
Nicolas Alejandre-Alba, Rocio Gutierrez-Contreras, Carlos Dorronsoro, Susana Marcos
Purpose: Accommodating intraocular lenses (A-IOLs) require capturing the ciliary muscle forces. Prior work demonstrated strong photo-initiated bonding between strips of capsular bag and poly(2-hydroxyethyl methacrylate); (pHEMA) polymer in an extraocular setting. We demonstrate that photobonding can be achieved intraocularly. Methods: Phacoemulsification was performed in porcine eyes (<24 hours postmortem). A commercial intraocular lens (IOL; pHEMA-MMA material) was inserted in the capsular bag...
September 2018: Translational Vision Science & Technology
Dongliang Wang, Huijie Hou, Jingping Hu, Jikun Xu, Long Huang, Shaogang Hu, Sha Liang, Keke Xiao, Bingchuan Liu, Jiakuan Yang
Bio-electro-Fenton (BEF) system holds great potential for sustainable degradation of refractory organics. Activated carbon (AC) air cathode was modified by co-pyrolyzing of AC with glucose and doping with nano-zero-valent iron (denoted as nZVI@MAC) in order to promote two-electron oxygen reduction reaction (2e- ORR) for enhanced oxidizing performance. Single chamber microbial fuel cells (SCMFCs) with nZVI@MAC cathode was examined to degrade landfill leachate. It was revealed that nZVI@MAC cathode SCMFC showed higher degradation efficiency towards landfill leachate...
January 2019: Chemosphere
Stella Nalukwago Settumba, Marian Shanahan, Willings Botha, Muhammad Zulilhaam Ramli, Georgina Mary Chambers
BACKGROUND: The contingent valuation (CV) method is an alternative approach to typical health economic methods for valuing interventions that have both health and non-health outcomes. Fertility treatment, such as in vitro fertilisation (IVF), fall into this category because of the significant non-health outcomes associated with having children. AIM: To estimate the general population's willingness to pay (WTP) for one cycle of IVF and one year of IVF treatment, and to test the reliability and validity of a CV instrument...
October 13, 2018: Applied Health Economics and Health Policy
Carlos Kofman, Alejandro Teper
Background: In vitro and scintigraphic studies have suggested that effectiveness of metered-dose inhalers (MDI) with nonvalved spacers (NVS) is similar to that of MDI with valved holding chambers (VHC). Nevertheless, there are no clinical studies that compare these techniques in long-term treatment with inhaled steroids in young children with recurrent wheezing and risk factors for asthma. Objective: To compare the efficacy of a long-term treatment with Fluticasone Propionate administered by an MDI through both type of spacers, with and without valves, in young children with recurrent wheezing and risk factors for asthma...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Susan LaRue, Jane Springer, Michael Noderer, James Meehan, Carol H Wysham
BACKGROUND: Ease of injection is important to patients. An autoinjector was developed to deliver exenatide, a glucagon-like peptide-1 receptor agonist for type 2 diabetes mellitus. For autoinjection, 0.06-mm exenatide-containing microspheres are suspended in medium-chain triglycerides. Herein, we report design verification and usability testing of the autoinjector for exenatide once-weekly suspension (QWS) delivery. METHODS: Exenatide QWS in a single-chamber cartridge is self-injected subcutaneously with three main steps: mix, unlock, and inject...
September 20, 2018: Journal of Diabetes Science and Technology
Yonglan Ruan, Leying Gu, Jinjin Yan, Jun Guo, Xiao Geng, Hao Shi, Guang Yu, Chan Zhu, Yan Yang, Yuan Zhou, Changming Wang, Zongxiang Tang
Detection of cold allodynia is a very important aspect in the study of pain behavior. An effective and concise device for detecting cold pain has always been the hope of many researchers. Here, an easily produced and operated cold plate device is presented for the assessment of cold allodynia in mice. The device used to detect cold allodynia has two components: a chamber consists of a cylinder for animal experiment and a cube box around the chamber for holding ice to keep temperature stable. In the testing chamber, a mouse was placed on the circular plexiglass plate steady at 4 °C above ice for five minutes...
September 18, 2018: Scientific Reports
Qiang Gao, Fei Wang, Xihong Lv, Hui Cao, Fei Su, Jianjun Zhou, Peien Leng
BACKGROUND: The near-surface urban drainage system in Shanghai is highly complex, with hundreds of thousands of catch basins (CBs) and manhole chambers (MCs). Comparatively little is known about the breeding of mosquitoes in this vast system, especially for the locally predominant species Aedes albopictus. A cross-sectional mosquito sampling study was conducted from late July to early August of 2017 using 539 CBs and 309 MCs located in 10 communities of downtown Shanghai. We measured the water-holding status of the drainage systems and density of mosquito larvae...
2018: PloS One
Lientra Q Lu, Michael B Strauss, Stuart S Miller
Introduction: Decompression sickness (DCS) has been associated with unusual circumstances such as breath-hold diving, shallow depths, and short bottom times. We report a case of DCS with an extraordinary cause and course. Materials and Methods: A 72-year-old healthy Hispanic female was referred to our 24/7 Hyperbaric Medicine Unit for emergency hyperbaric oxygen recompression treatment (HBO2 RCT) after developing lower-extremity paralysis following a hyperbaric air exposure in a homemade hyperbaric chamber...
May 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Walter Vincken, Mark L Levy, Jane Scullion, Omar S Usmani, P N Richard Dekhuijzen, Chris J Corrigan
We present an extensive review of the literature to date pertaining to the rationale for using a spacer/valved holding chamber (VHC) to deliver inhaled therapy from a pressurised, metered-dose inhaler, a discussion of how the properties of individual devices may vary according to their physical characteristics and materials of manufacture, the potential risks and benefits of ancillaries such as valves, and the evidence that they contribute tangibly to the delivery of therapy. We also reiterate practical recommendations for the correct usage and maintenance of spacers/VHCs, which we trust offer practical help and advice to patients and healthcare professionals alike...
April 2018: ERJ Open Research
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