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https://www.readbyqxmd.com/read/28922744/sugar-transporters-in-plants-new-insights-and-discoveries
#1
Benjamin T Julius, Kristen A Leach, Thu M Tran, Rachel A Mertz, David M Braun
Carbohydrate partitioning is the process of carbon assimilation and distribution from source tissues, such as leaves, to sink tissues, such as stems, roots and seeds. Sucrose, the primary carbohydrate transported long distance in many plant species, is loaded into the phloem and unloaded into distal sink tissues. However, many factors, both genetic and environmental, influence sucrose metabolism and transport. Therefore, understanding the function and regulation of sugar transporters and sucrose metabolic enzymes is key to improving agriculture...
September 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28922606/three-dimensional-nico2o4-mnmoo4-core-shell-nanoarrays-for-high-performance-asymmetric-supercapacitors
#2
Yuliang Yuan, Weicheng Wang, Jie Yang, Haichao Tang, Zhizhen Ye, Yujia Zeng, Jianguo Lu
Design of new materials with sophisticated nanostructure has been proven to be an efficient strategy to improve their properties in many applications. Herein, we demonstrate the successful combination of high electron conductive materials of NiCo2O4 with the high capacitance materials of MnMoO4 by forming a core-shell nanostructure. The NiCo2O4@MnMoO4 core-shell nanoarrays (CSNAs) electrode possesses high specific capacitance of 4.24 F cm-2 at a current density of 5 mA cm-2, obviously larger than the pristine NiCo2O4 electrode...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28920981/oxygenation-of-rzn-n-o-type-complexes-as-an-efficient-route-to-zinc-alkoxides-not-accessible-via-the-classical-alcoholysis-path
#3
Zbigniew Wróbel, Tomasz Pietrzak, Iwona Justyniak, Janusz Lewiński
The controlled oxygenation of alkylzinc complexes supported by a 2-ester substituted pyrrolate ligand (L) leads to zinc alkoxides with an uncommon structural motif in the solid state: a trimer [(L)Zn(μ-O(t)Bu)]3 with the central [Zn3(μ-OR)3] ring and a tetramer [(L)Zn(μ3-OEt)]4 with a heterocubane-type structure. Strikingly, these seemingly simple zinc alkoxides are not accessible via the classical alcoholysis route.
September 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28920694/gold-catalyzed-synthesis-of-1-indol-3-yl-carbazoles-selective-1-2-alkyl-vs-1-2-vinyl-migration
#4
Anisley Suárez, Samuel Suárez-Pantiga, Olalla Nieto-Faza, Roberto Sanz
Gold(III)-catalyzed cycloisomerization of α-bis(indol-3-yl)methyl alkynols selectively affords 1-(indol-3-yl)carbazoles, in a transformation that takes place through a selective 1,2-alkyl vs 1,2-vinyl migration step in the vinyl-gold intermediate generated from the initial 5-endo-spirocyclization. The reaction proceeds well with either tertiary or secondary starting alkynols as well as with a wide variety of alkyne substituents. The key role of the other indol-3-yl substituent for the unexpected selectivity in the 1,2 rearrangement has also been supported by DFT calculations that reveal a low barrier, two-step mechanism in the alkyl migration path where the second indole significantly stabilizes a carbocationic intermediate...
September 18, 2017: Organic Letters
https://www.readbyqxmd.com/read/28920684/stilbene-boronic-acids-form-a-covalent-bond-with-human-transthyretin-and-inhibit-its-aggregation
#5
Thomas P Smith, Ian W Windsor, Katrina T Forest, Ronald T Raines
Transthyretin (TTR) is a homotetrameric protein. Its dissociation into monomers leads to the formation of fibrils that underlie human amyloidogenic diseases. The binding of small molecules to the thyroxin-binding sites in TTR stabilizes the homotetramer and attenuates TTR amyloidosis. Herein, we report on boronic acid-substituted stilbenes that limit TTR amyloidosis in vitro. Assays of affinity for TTR and inhibition of its tendency to form fibrils were coupled with X-ray crystallographic analysis of nine TTR·ligand complexes...
September 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28920670/fabrication-of-hierarchical-porous-carbon-nanoflakes-for-high-performance-supercapacitors
#6
Yamin Yao, Yunqiang Zhang, Li Li, Shulan Wang, Shi Xue Dou, Xuan Liu
In the current work, the carbon nanoflakes (CNs-Fe/KOH) and porous carbon (PC-Ni/KOH) have been produced by using Fe(NO3)3/KOH and Ni(NO3)2/KOH as the co-graphitization/activation catalysts to treat the natural plane tree fluff, respectively. The as-prepared carbon materials show different morphologies when treated with different metal ions. Compared with PC-Ni/KOH, the CNs-Fe/KOH have both high graphitization degree (IG/ID = 1.53) and large SBET (1416 m2/g). In a three-electrode setup, the CNs-Fe/KOH electrode shows a high specific capacitance of 253 F/g at 10 A/g, with a capacitance retention of 92...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28920438/conduction-mechanisms-at-interface-of-aln-sin-dielectric-stacks-with-algan-gan-heterostructures-for-normally-off-high-electron-mobility-transistors-correlating-device-behavior-with-nanoscale-interfaces-properties
#7
Giuseppe Greco, Patrick Fiorenza, Ferdinando Iucolano, Andrea Severino, Filippo Giannazzo, Fabrizio Roccaforte
In this work, the conduction mechanisms at the interface of AlN/SiN dielectric stacks with AlGaN/GaN heterostructures have been studied combining different macroscopic and nanoscale characterizations on bare materials and devices. The AlN/SiN stacks grown on the recessed region of AlGaN/GaN heterostructures have been used as gate dielectric of hybrid metal-insulator-semiconductor high electron mobility transistors (MISHEMTs), showing a normally-off behaviour (Vth=+1.2 V), high channel mobility (204 cm(2)V(-1)s(-1)), and very good switching behaviour (ION/IOFF current ratio of 5-6×10(8) and sub-threshold swing of 90 mV/dec)...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28919500/hydrogen-and-oxygen-trapping-at-the-h-cluster-of-fefe-%C3%A2-hydrogenase-revealed-by-site-selective-spectroscopy-and-qm-mm-calculations
#8
Stefan Mebs, Ramona Kositzki, Jifu Duan, Moritz Senger, Florian Wittkamp, Ulf-Peter Apfel, Thomas Happe, Sven T Stripp, Martin Winkler, Michael Haumann
[FeFe]‑hydrogenases are superior hydrogen conversion catalysts. They bind a cofactor (H-cluster) comprising a four‑iron and a diiron unit with three carbon monoxide (CO) and two cyanide (CN(-)) ligands. Hydrogen (H2) and oxygen (O2) binding at the H-cluster was studied in the C169A variant of [FeFe]‑hydrogenase HYDA1, in comparison to the active oxidized (Hox) and CO-inhibited (Hox-CO) species in wildtype enzyme. (57)Fe labeling of the diiron site was achieved by in vitro maturation with a synthetic cofactor analogue...
September 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28919263/single-cell-gene-expression-analysis-of-a-human-esc-model-of-pancreatic-endocrine-development-reveals-different-paths-to-%C3%AE-cell-differentiation
#9
Maja Borup Kjær Petersen, Ajuna Azad, Camilla Ingvorsen, Katja Hess, Mattias Hansson, Anne Grapin-Botton, Christian Honoré
The production of insulin-producing β cells from human embryonic stem cells (hESCs) in vitro represents a promising strategy for a cell-based therapy for type 1 diabetes mellitus. To explore the cellular heterogeneity and temporal progression of endocrine progenitors and their progeny, we performed single-cell qPCR on more than 500 cells across several stages of in vitro differentiation of hESCs and compared them with human islets. We reveal distinct subpopulations along the endocrine differentiation path and an early lineage bifurcation toward either polyhormonal cells or β-like cells...
September 8, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28918714/is-there-a-dark-side-to-mindfulness-relation-of-mindfulness-to-criminogenic-cognitions
#10
June P Tangney, Ashley E Dobbins, Jeffrey B Stuewig, Shannon W Schrader
In recent years, mindfulness-based interventions have been modified for use with inmate populations, but how this might relate to specific criminogenic cognitions has not been examined empirically. Theoretically, characteristics of mindfulness should be incompatible with distorted patterns of criminal thinking, but is this in fact the case? Among both 259 male jail inmates and 516 undergraduates, mindfulness was inversely related to the Criminogenic Cognitions Scale (CCS) through a latent variable of emotion regulation...
October 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28918686/sensitivity-of-post-treatment-positron-emission-tomography-computed-tomography-to-detect-inter-fractional-range-variations-in-scanned-ion-beam-therapy
#11
Josefine Handrack, Thomas Tessonnier, Wenjing Chen, Jakob Liebl, Jürgen Debus, Julia Bauer, Katia Parodi
BACKGROUND: Ion therapy, especially with modern scanning beam delivery, offers very sharp dose gradients for highly conformal cancer treatment. However, it is very sensitive to uncertainties of tissue stopping properties as well as to anatomical changes and setup errors, making range verification highly desirable. To this end, positron emission tomography (PET) can be used to measure decay products of β(+)-emitters created in interactions inside the patient. This work investigates the sensitivity of post treatment PET/CT (computed tomography) to detect inter-fractional range variations...
September 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28918526/coupling-population-dynamics-with-earth-system-models-the-popem-model
#12
Andrés Navarro, Raúl Moreno, Alfonso Jiménez-Alcázar, Francisco J Tapiador
Precise modeling of CO2 emissions is important for environmental research. This paper presents a new model of human population dynamics that can be embedded into ESMs (Earth System Models) to improve climate modeling. Through a system dynamics approach, we develop a cohort-component model that successfully simulates historical population dynamics with fine spatial resolution (about 1°×1°). The population projections are used to improve the estimates of CO2 emissions, thus transcending the bulk approach of existing models and allowing more realistic non-linear effects to feature in the simulations...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28918521/relation-of-parent-knowledge-to-glycemic-control-among-emerging-adults-with-type-1-diabetes-a-mediational-model
#13
Vicki S Helgeson, Abigail Kunz Vaughn, Howard Seltman, Trevor Orchard, Dorothy Becker, Ingrid Libman
The study goal was to examine the links of parent knowledge of children's behavior to diabetes outcomes and to test a mediational model that focused on psychological distress and self-care behavior. We recruited 132 adolescents (average age 12) and followed them to average age 23. At age 23 (n = 107), we conducted in-person interviews with these emerging adults to measure parent knowledge, psychological distress, self-care behavior and glycemic control. We used structural equation modeling to test our hypotheses with these cross-sectional data...
September 16, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28918286/identifying-combinatorial-biomarkers-by-association-rule-mining-in-the-camd-alzheimer-s-database
#14
Balázs Szalkai, Vince K Grolmusz, Vince I Grolmusz
The concept of combinatorial biomarkers was conceived when it was noticed that simple biomarkers are often inadequate for recognizing and characterizing complex diseases. Here we present an algorithmic search method for complex biomarkers which may predict or indicate Alzheimer's disease (AD) and other kinds of dementia. We show that our method is universal since it can describe any Boolean function for biomarker discovery. We applied data mining techniques that are capable to uncover implication-like logical schemes with detailed quality scoring...
August 17, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28918259/disrupted-structural-and-functional-connectivity-networks-in-ischemic-stroke-patients
#15
Jingna Zhang, Ye Zhang, Li Wang, Linqiong Sang, Jun Yang, Rubing Yan, Pengyue Li, Jian Wang, Mingguo Qiu
Local lesions caused by stroke may result in extensive structural and functional reorganization in the brain. Previous studies of this phenomenon have focused on specific brain networks. Here, we aimed to discover abnormalities in whole-brain networks and to explore the decoupling between structural and functional connectivity in patients with stroke. Fifteen ischemic stroke patients and 23 normal controls (NCs) were recruited in this study. A graph theoretical analysis was employed to investigate the abnormal topological properties of structural and functional brain networks in patients with stroke...
September 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28918233/the-role-of-callous-unemotional-traits-in-mediating-the-association-between-animal-abuse-exposure-and-behavior-problems-among-children-exposed-to-intimate-partner-violence
#16
Shelby Elaine McDonald, Julia Dmitrieva, Sunny Shin, Stephanie A Hitti, Sandra A Graham-Bermann, Frank R Ascione, James Herbert Williams
Children exposed to intimate partner violence are at increased risk for concomitant exposure to maltreatment of companion animals. There is emerging evidence that childhood exposure to maltreatment of companion animals is associated with psychopathology in childhood and adulthood. However, few studies have explored developmental factors that might help to explain pathways from animal maltreatment exposure to children's maladjustment. The present study addresses this gap in the literature by examining relations between children's exposure to animal maltreatment, callous/unemotional traits (i...
September 14, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28918095/accessibility-and-usability-of-parks-and-playgrounds
#17
Meredith A Perry, Hemakumar Devan, Harry Fitzgerald, Karen Han, Li-Ting Liu, Jack Rouse
BACKGROUND: Public parks and playgrounds are an environment for leisure activity, which all generations can enjoy at low or no financial cost. Evaluating the accessibility and usability of parks and playgrounds is crucial because their design, environment (natural and built) and safety could restrict participation of persons with disabilities. OBJECTIVE: To evaluate the accessibility and usability of 21 public parks and playgrounds in three metropolitan cities of New Zealand...
September 8, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28917958/the-path-to-longer-and-healthier-lives-for-all-africans-by-2030-the-lancet-commission-on-the-future-of-health-in-sub-saharan-africa
#18
Irene Akua Agyepong, Nelson Sewankambo, Agnes Binagwaho, Awa Marie Coll-Seck, Tumani Corrah, Alex Ezeh, Abebaw Fekadu, Nduku Kilonzo, Peter Lamptey, Felix Masiye, Bongani Mayosi, Souleymane Mboup, Jean-Jacques Muyembe, Muhammad Pate, Myriam Sidibe, Bright Simons, Sheila Tlou, Adrian Gheorghe, Helena Legido-Quigley, Joanne McManus, Edmond Ng, Maureen O'Leary, Jamie Enoch, Nicholas Kassebaum, Peter Piot
No abstract text is available yet for this article.
September 13, 2017: Lancet
https://www.readbyqxmd.com/read/28917864/bulk-vs-nano-zno-influence-of-fire-retardant-behavior-on-sisal-fibre-yarn
#19
Mahendra Sheshama, Hitesh Khatri, Manish Suthar, Santanu Basak, Wazed Ali
Flame retardant functionality was imparted in sisal (leaf fibre) yarn whereas a strong scientific finding has been established between fire retardant efficacy of bulk and nano zinc oxide based formulations. Bulk and nano ZnO treated sisal yarns have been compared on the basis of their flame retardant efficacy, weight add-on% and tensile strength. Limiting oxygen index and char length of the 12% ZnO treated sisal was found to be well comparable with the 1% nano ZnO treated yarn. Further, add-on% and the tensile strength of the nano ZnO treated sample is 70-80% lower and 20% more, respectively, compared to the 12% bulk ZnO treated sisal yarn...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917669/knowledge-driven-computational-modeling-in-alzheimer-s-research-current-state-and-future-trends
#20
Hugo Geerts, Martin Hofmann-Apitius, Thomas J Anastasio
Neurodegenerative diseases such as Alzheimer's disease (AD) follow a slowly progressing dysfunctional trajectory, with a large presymptomatic component and many comorbidities. Using preclinical models and large-scale omics studies ranging from genetics to imaging, a large number of processes that might be involved in AD pathology at different stages and levels have been identified. The sheer number of putative hypotheses makes it almost impossible to estimate their contribution to the clinical outcome and to develop a comprehensive view on the pathological processes driving the clinical phenotype...
September 14, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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