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https://www.readbyqxmd.com/read/28110114/tropoelastin-coated-plla-plga-scaffolds-promote-vascular-network-formation
#1
Shira Landau, Ariel A Szklanny, Giselle C Yeo, Yulia Shandalov, Elena Kosobrodova, Anthony S Weiss, Shulamit Levenberg
The robust repair of large wounds and tissue defects relies on blood flow. This vascularization is the major challenge faced by tissue engineering on the path to forming thick, implantable tissue constructs. Without this vasculature, oxygen and nutrients cannot reach the cells located far from host blood vessels. To make viable constructs, tissue engineering takes advantage of the mechanical properties of synthetic materials, while combining them with ECM proteins to create a natural environment for the tissue-specific cells...
January 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28110061/droplet-based-characterization-of-surfactant-efficacy-in-colloidal-stabilization-of-carbon-black-in-nonpolar-solvents
#2
Blake J Bleier, Benjamin A Yezer, Ben J Freireich, Shelley L Anna, Lynn M Walker
Development of an electrostatic stabilization mechanism for colloidal suspensions in nonpolar fluids requires an improved understanding of the interactions between the inverse micelles and particles as well as the roles that steric and electrostatic effects play. A droplet-based millifluidic device is designed and used to investigate the stabilization effects of surfactants on colloidal suspensions. A system containing carbon black and the surfactant OLOA 11000 suspended in dodecane is chosen as a well-characterized system to study sedimentation quantitatively...
January 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28109669/different-alterations-in-brain-functional-networks-according-to-direct-and-indirect-topological-connections-in-patients-with-schizophrenia
#3
Chang-Hyun Park, Seungyup Lee, Taewon Kim, Wang Yeon Won, Kyoung-Uk Lee
Schizophrenia displays connectivity deficits in the brain, but the literature has shown inconsistent findings about alterations in global efficiency of brain functional networks. We supposed that such inconsistency at the whole brain level may be due to a mixture of different portions of global efficiency at sub-brain levels. Accordingly, we considered measuring portions of global efficiency in two aspects: spatial portions by considering sub-brain networks and topological portions by considering contributions to global efficiency according to direct and indirect topological connections...
January 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28109451/revictimization-after-adolescent-dating-violence-in-a-matched-national-sample-of-youth
#4
Deinera Exner-Cortens, John Eckenrode, John Bunge, Emily Rothman
PURPOSE: To assess if adolescent dating violence was associated with physical intimate partner violence victimization in adulthood, using a comprehensive propensity score to create a matched group of victims and nonvictims. METHODS: Secondary analysis of waves 1 (1994-1995), 2 (1996), 3 (2001-2002) and 4 (2007-2008) of the National Longitudinal Study of Adolescent to Adult Health, a nationally representative sample of US high schools and middle schools. Individuals aged 12-18 reporting adolescent dating violence between the wave 1 and 2 interviews (n = 732) were matched to nonvictimized participants of the same sex (n = 1,429) using propensity score matching...
February 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28109229/comparative-investigation-of-pure-and-mixed-rare-gas-atoms-on-coronene-molecules
#5
Rocío Rodríguez-Cantano, Massimiliano Bartolomei, Marta I Hernández, José Campos-Martínez, Tomás González-Lezana, Pablo Villarreal, Ricardo Pérez de Tudela, Fernando Pirani, Javier Hernández-Rojas, José Bretón
Clusters formed by the combination of rare gas (RG) atoms of He, Ne, Ar, and Kr on coronene have been investigated by means of a basin-hopping algorithm and path integral Monte Carlo calculations at T = 2 K. Energies and geometries have been obtained and the role played by the specific RG-RG and RG-coronene interactions on the final results is analysed in detail. Signatures of diffuse behavior of the He atoms on the surface of the coronene are in contrast with the localization of the heavier species, Ar and Kr...
January 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28109068/the-impact-of-dermoscopy-on-melanoma-detection-in-the-practice-of-dermatologists-in-europe-results-of-a-pan-european-survey
#6
A M Forsea, P Tschandl, I Zalaudek, V Del Marmol, H P Soyer, G Argenziano, A C Geller
BACKGROUND: Dermoscopy is a widely used technique that can increase the sensitivity and specificity of melanoma detection. Information is lacking on the impact of dermoscopy use on the detection of melanoma in the real-life practice of European dermatologists. OBJECTIVE: To identify factors that influence the benefit of using dermoscopy for increasing melanoma detection and lowering the number of unnecessary biopsies in the practice of European dermatologists. METHODS: We conducted a survey of dermatologists registered in 32 European countries regarding: the demographic and practice characteristics, dermoscopy training and use, opinions on dermoscopy and the self-estimated impact of dermoscopy use on the number of melanomas detected and the number of unnecessary biopsies performed in practice...
January 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28108494/the-rich-club-organization-in-rat-functional-brain-network-to-balance-between-communication-cost-and-efficiency
#7
Xia Liang, Li-Ming Hsu, Hanbing Lu, Akira Sumiyoshi, Yong He, Yihong Yang
Network analyses of structural connectivity in the brain have highlighted a set of highly connected hubs that are densely interconnected, forming a "rich-club" substrate in diverse species. Here, we demonstrate the existence of rich-club organization in functional brain networks of rats. Densely interconnected rich-club regions are found to be distributed in multiple brain modules, with the majority located within the putative default mode network. Rich-club members exhibit high wiring cost (as measured by connection distance) and high metabolic running cost (as surrogated by cerebral blood flow), which may have evolved to achieve high network communications to support efficient brain functions...
January 19, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28108014/electrocardiographic-spatial-loops-indicate-organization-of-atrial-fibrillation-minutes-before-ablation-related-transitions-to-atrial-tachycardia
#8
Tina Baykaner, Rishi Trikha, Junaid A B Zaman, David E Krummen, Paul J Wang, Sanjiv M Narayan
BACKGROUND: During ablation for atrial fibrillation (AF), it is challenging to anticipate transitions to organized tachycardia (AT). Defining indices of this transition may help to understand fibrillatory conduction and help track therapy. OBJECTIVE: To determine the timescale over which atrial fibrillation (AF) organizes en route to atrial tachycardia (AT) using the ECG referenced to intracardiac electrograms. METHODS: In 17 AF patients at ablation (58...
January 15, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28107926/detection-of-silver-nanoparticles-in-seawater-at-ppb-levels-using-uv-visible-spectrophotometry-with-long-path-cells
#9
Pablo Lodeiro, Eric P Achterberg, Mohammad S El-Shahawi
Silver nanoparticles (AgNPs) are emerging contaminants that are difficult to detect in natural waters. UV-visible spectrophotometry is a simple technique that allows detection of AgNPs through analysis of their characteristic surface plasmon resonance band. The detection limit for nanoparticles using up to 10cm path length cuvettes with UV-visible spectrophotometry is in the 0.1-10ppm range. This detection limit is insufficiently low to observe AgNPs in natural environments. Here we show how the use of capillary cells with an optical path length up to 200cm, forms an excellent technique for rapid detection and quantification of non-aggregated AgNPs at ppb concentrations in complex natural matrices such as seawater...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107466/thermal-conductivity-performance-of-polypropylene-composites-filled-with-polydopamine-functionalized-hexagonal-boron-nitride
#10
Lin Chen, Hong-Fei Xu, Shao-Jian He, Yi-Hang Du, Nan-Jie Yu, Xiao-Ze Du, Jun Lin, Sergei Nazarenko
Mussel-inspired approach was attempted to non-covalently functionalize the surfaces of boron nitride (BN) with self-polymerized dopamine coatings in order to reduce the interfacial thermal barrier and enhance the thermal conductivity of BN-containing composites. Compared to the polypropylene (PP) composites filled with pristine BN at the same filler content, thermal conductivity was much higher for those filled with both functionalized BN (f-BN) and maleic anhydride grafted PP (PP-g-ma) due to the improved filler dispersion and better interfacial filler-matrix compatibility, which facilitated the development of more thermal paths...
2017: PloS One
https://www.readbyqxmd.com/read/28107449/the-impact-of-shame-self-criticism-and-social-rank-on-eating-behaviours-in-overweight-and-obese-women-participating-in-a-weight-management-programme
#11
Cristiana Duarte, Marcela Matos, R James Stubbs, Corinne Gale, Liam Morris, Jose Pinto Gouveia, Paul Gilbert
Recent research has suggested that obesity is a stigmatised condition. Concerns with personal inferiority (social rank), shame and self-criticism may impact on weight management behaviours. The current study examined associations between social comparison (shame, self-criticism), negative affect and eating behaviours in women attending a community based weight management programme focused on behaviour change. 2,236 participants of the programme completed an online survey using measures of shame, self-criticism, social comparison, and weight-related affect, which were adapted to specifically address eating behaviour, weight and body shape perceptions...
2017: PloS One
https://www.readbyqxmd.com/read/28107248/how-mice-are-indispensable-for-understanding-obesity-and-diabetes-genetics
#12
Alan D Attie, Gary A Churchill, Joseph H Nadeau
PURPOSE OF REVIEW: The task of cataloging human genetic variation and its relation to disease is rapidly approaching completion. The new challenge is to discover the function of disease-associated genes and to understand the pathways that lead to human disease. We propose that achieving this new level of understanding will increasingly rely on the use of model organisms. We discuss the advantages of the mouse as a model organism. RECENT FINDINGS: The collection of available mouse strains represents as much genetic and phenotype variation as is found in the human population...
January 19, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28107180/identification-of-micrornas-implicated-in-the-late-differentiation-stages-of-normal-b-cells-suggests-a-central-role-for-mirna-targets-zeb1-and-tp53
#13
Giorgio Malpeli, Stefano Barbi, Simonetta Zupo, Gabriele Tosadori, Giovanni Scardoni, Anna Bertolaso, Silvia Sartoris, Stefano Ugel, Caterina Vicentini, Matteo Fassan, Annalisa Adamo, Mauro Krampera, Maria Teresa Scupoli, Carlo Maria Croce, Aldo Scarpa
In the late B cell differentiation stages, miRNAs expression modifications promoting or inhibiting key pathways are only partially defined. We isolated 29 CD19+ human B cell samples at different stages of differentiation: B cells from peripheral blood; naïve, germinal center (GC) and subepithelial (SE) B cells from tonsils. SE cells were further split in activated and resting B cell. The miRNA expression profile of these B cells was assessed by microarray analysis and selected miRNAs were validated by quantitative RT-PCR and in situ hybridization on normal tonsils...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28107045/examining-bidirectional-pathways-between-exposure-to-political-violence-and-adolescent-adjustment-in-northern-ireland
#14
E Mark Cummings, Laura K Taylor, Han Du, Christine E Merrilees, Marcie Goeke-Morey, Peter Shirlow
Research on social ecologies of political violence has been largely confined to cross-sectional tests of the impact of political violence on child adjustment, limiting perspectives on more nuanced causal pathways, including tests of reciprocal relations between exposure to political violence and child adjustment. Based on a four-wave longitudinal study, this research breaks new ground in assessing bidirectional relations between exposure to political violence in the form of experience with sectarian antisocial behavior and adolescents' adjustment problems...
January 20, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28107041/sleep-and-optimism-a-longitudinal-study-of-bidirectional-causal-relationship-and-its-mediating-and-moderating-variables-in-a-chinese-student-sample
#15
Esther Yuet Ying Lau, C Harry Hui, Jasmine Lam, Shu-Fai Cheung
While both sleep and optimism have been found to be predictive of well-being, few studies have examined their relationship with each other. Neither do we know much about the mediators and moderators of the relationship. This study investigated (1) the causal relationship between sleep quality and optimism in a college student sample, (2) the role of symptoms of depression, anxiety, and stress as mediators, and (3) how circadian preference might moderate the relationship. Internet survey data were collected from 1,684 full-time university students (67...
January 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28107034/automated-measurement-of-magnesium-calcium-ratios-in-gastropod-shells-using-laser-induced-breakdown-spectroscopy-for-paleoclimatic-applications
#16
Adolfo Cobo, Asier García-Escárzaga, Igor Gutiérrez-Zugasti, Jesús Setién, Manuel R González-Morales, José Miguel López-Higuera
The chemical composition of mollusk shells offers information about environmental conditions present during the lifespan of the organism. Shells found in geological deposits and in many archeological sites can help to reconstruct past climatic conditions. For example, a correlation has been found between seawater temperature and the amount of some substituent elements (e.g., magnesium, strontium) in the biogenerated calcium carbonate matrix of the shell, although it is very species-specific. Here we propose the use laser-induced breakdown spectroscopy (LIBS) to estimate Mg/Ca ratios in modern specimens of the common limpet Patella vulgata...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28106960/a-novel-technique-to-exclude-the-left-ventricle-with-an-assist-device
#17
Stefan Klotz, Roza MeyerSaraei, Alex Frydrychowicz, Michael Scharfschwerdt, Andreas Koertge, Leon Putman, Hans Sievers
Left ventricular assist device implantation disrupts the natural intracavitary blood flow path through the heart, introducing flow patterns potentially associated with thrombosis, especially around the inflow cannula. We describe a novel technique for completely excluding the left ventricle with an assist device by using a cone shaped ring-reinforced prosthesis.
December 9, 2016: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/28106768/lipid-and-glycolipid-isomer-analyses-using-ultra-high-resolution-ion-mobility-spectrometry-separations
#18
Roza Wojcik, Ian K Webb, Liulin Deng, Sandilya V B Garimella, Spencer A Prost, Yehia M Ibrahim, Erin S Baker, Richard D Smith
Understanding the biological roles and mechanisms of lipids and glycolipids is challenging due to the vast number of possible isomers that may exist. Mass spectrometry (MS) measurements are currently the dominant approach for studying and providing detailed information on lipid and glycolipid presence and changes. However, difficulties in distinguishing the many structural isomers, due to the distinct lipid acyl chain positions, double bond locations or specific glycan types, inhibit the delineation and assignment of their biological roles...
January 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106670/reward-motivation-and-emotion-of-pain-and-its-relief
#19
Frank Porreca, Edita Navratilova
The experience of pain depends on interpretation of context and past experience that guide the choice of an immediate behavioral response and influence future decisions of actions to avoid harm. The aversive qualities of pain underlie its physiological role in learning and motivation. In this review, we highlight findings from human and animal investigations that suggest that both pain, and the relief of pain, are complex emotions that are comprised of feelings and their motivational consequences. Relief of aversive states, including pain, is rewarding...
January 12, 2017: Pain
https://www.readbyqxmd.com/read/28106594/big-data-and-nursing-implications-for-the-future
#20
Maxim Topaz, Lisiane Pruinelli
Big data is becoming increasingly more prevalent and it affects the way nurses learn, practice, conduct research and develop policy. The discipline of nursing needs to maximize the benefits of big data to advance the vision of promoting human health and wellbeing. However, current practicing nurses, educators and nurse scientists often lack the required skills and competencies necessary for meaningful use of big data. Some of the key skills for further development include the ability to mine narrative and structured data for new care or outcome patterns, effective data visualization techniques, and further integration of nursing sensitive data into artificial intelligence systems for better clinical decision support...
2017: Studies in Health Technology and Informatics
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