Chiara Raggi, Elena Gammella, Margherita Correnti, Paolo Buratti, Elisa Forti, Jesper B Andersen, Gianfranco Alpini, Shannon Glaser, Domenico Alvaro, Pietro Invernizzi, Gaetano Cairo, Stefania Recalcati
Cholangiocarcinoma (CCA) is a devastating liver tumour arising from malignant transformation of bile duct epithelial cells. Cancer stem cells (CSC) are a subset of tumour cells endowed with stem-like properties, which play a role in tumour initiation, recurrence and metastasis. In appropriate conditions, CSC form 3D spheres (SPH), which retain stem-like tumour-initiating features. Here, we found different expression of iron proteins indicating increased iron content, oxidative stress and higher expression of CSC markers in CCA-SPH compared to tumour cells growing as monolayers...
December 15, 2017: Scientific Reports