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Jupil Ko, Adam Rosen, Cathleen N Brown
Determining the clinical utility of functional performance tests (FPTs) and establishing cutoff scores could be useful in identifying those athletes who could benefit from effective injury prevention interventions. Our purpose was to determine the accuracy of FPTs in identifying adolescent athletes who go on to experience lateral ankle sprain(s) and establish specific cutoff scores capable of identifying those who sustain a lateral ankle sprain in the near future. Sixty-four participants (age = 15.5 ± 1.3yrs; height = 161...
August 18, 2018: Scandinavian Journal of Medicine & Science in Sports
Stephen D Stamatis, Lee E Kirsch
A quantitative, model-based risk assessment process was evaluated using Bayesian parameter estimation to determine the posterior distribution of the probability of a model tablet formulation's (gabapentin) ability to meet end-of-expiry stability criteria-based manufacturing controls. Experimental data was obtained from an FDA-supported, multi-year project that involved researchers at nine universities working collaboratively with industrial and governmental scientists under the leadership of the National Institute for Pharmaceutical Technology and Education (NITPE)...
August 17, 2018: AAPS PharmSciTech
Anatole V Wiik, Mads Brevadt, Hardeep Johal, Kartik Logishetty, Oliver Boughton, Adeel Aqil, Justin P Cobb
BACKGROUND: The purpose of this study was to examine the gait pattern of total hip arthroplasty (THA) patients with a new short femoral stem at different speeds and inclinations. MATERIALS AND METHODS: A total of 40 unilateral THA patients were tested on an instrumented treadmill. They comprised two groups (shorter stemmed THA n = 20, longer stemmed THA n = 20), both which had the same surgical posterior approach. The shorter femoral stemmed patients were taken from an ongoing hip trial with minimum 12 months postop...
August 17, 2018: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
Andreas Keßler, Dalia Kaisarly, Reinhard Hickel, Karl-Heinz Kunzelmann
OBJECTIVES: This study aimed to assess the effects of fiber incorporation on the contraction stress (CS), time to gelation (TG), and temperature rise (TR) features of two experimental resin-based composites (RBCs) in comparison to those of bulk-fill RBCs and conventional RBCs in simulated, clinically relevant cavities. MATERIALS AND METHODS: CS over 300 s, TG and TR were assessed by a stress-strain analyzer (SSA T80) in two cavity configurations (2 × 4 × 4 mm3 /4 × 4 × 4 mm3 /configuration value [Formula: see text] and [Formula: see text]) for two experimental RBCs, eight bulk-fill RBCs (EverX Posterior, Filtek Bulk Fill, SDR, SonicFill, Tetric EvoCeram Bulk Fill, Venus Bulk Fill, X-tra base, and X-tra Fill) and one RBC (Filtek Supreme XTE) by light curing (1200 mW/cm2 ) (n = 10)...
August 17, 2018: Clinical Oral Investigations
Takahisa Tainaka, Hiroo Uchida, Yujiro Tanaka, Akinari Hinoki, Chiyoe Shirota, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Kazuo Oshima, Kosuke Chiba, Tetsuya Ishimaru, Hiroshi Kawashima
PURPOSE: Laparoscopic-assisted anorectoplasty (LAARP) is a minimally invasive procedure in which the levator ani muscle is left to potentially improve postoperative fecal continence. This study aimed to retrospectively evaluate postoperative complications and long-term outcomes of fecal continence after LAARP and compare them to those after posterior sagittal anorectoplasty (PSARP). METHODS: Forty-five male patients with high and intermediate anorectal malformation (aged ≥ 4 years) who underwent LAARP or PSARP (LAARP 29, PSARP 16) from 1999 to 2013 were included...
August 17, 2018: Pediatric Surgery International
Felice D'Arco, Faraan Khan, Kshitij Mankad, Mario Ganau, Pablo Caro-Dominguez, Sotirios Bisdas
Central nervous system neoplasms are the most common solid tumours that develop in children, with the greatest proportion located in the infratentorium. The 2016 World Health Organization Central Nervous System tumour classification evolved from the 2007 edition with the integration of molecular and genetic profiling into the diagnosis, the addition of new entities and the removal of others. Radiology can assist with the subtyping of tumours from certain characteristics described below to provide prognostic information and guide further management...
August 17, 2018: Pediatric Radiology
Timo Grimmer, Kuangyu Shi, Janine Diehl-Schmid, Bianca Natale, Alexander Drzezga, Stefan Förster, Hans Förstl, Markus Schwaiger, Igor Yakushev, Hans-Jürgen Wester, Alexander Kurz, Behrooz Hooshyar Yousefi
18 F-FIBT, 2-(p-Methylaminophenyl)-7-(2-[18 F]fluoroethoxy)imidazo-[2,1-b]benzothiazole, is a new selective PET tracer under clinical investigation to specifically image β-amyloid depositions (Aβ) in humans in-vivo that binds to Aβ with excellent affinity (Kd 0.7 ± 0.2) and high selectivity over tau and α-synuclein aggregates (Ki > 1000 nM). We aimed to characterize 18 F-FIBT in a series of patients with different clinical-pathophysiological phenotypes and to compare its binding characteristics to the reference compound PiB...
August 17, 2018: Molecular Psychiatry
Liliana M Dávalos, Winston C Lancaster, Miguel S Núñez-Novas, Yolanda M León, Bonnie Lei, Jon Flanders, Amy L Russell
Determining the processes responsible for phenotypic variation is one of the central tasks of evolutionary biology. While the importance of acoustic traits for foraging and communication in echolocating mammals suggests adaptation, the seldom-tested null hypothesis to explain trait divergence is genetic drift. Here we derive FST values from multi-locus coalescent isolation-with-migration models, and couple them with estimates of quantitative trait divergence, or PST , to test drift as the evolutionary process responsible for phenotypic divergence in island populations of the Pteronotus parnellii species complex...
August 17, 2018: Heredity
He Tang, Na Li, Zhan Li, Meiju Zhang, Meirong Wei, Changbing Huang, Jihong Wang, Fuxin Li, Hong Wang, Zijiang Liu, Liying He, Yangyang Cheng, Wei Chen, Liwen Jin, Limin Gong, Jun Lu, Yan Xue, Manxiang Su, Yanhong Wang, Haiming Mo, Zhenwen Chen, Wei Guo, Yun Li, Hong Pan, Wei Zhang, Xu Ma, Xi Jin, Binbin Wang
BACKGROUND: The prevalence of ocular abnormalities of newborn in China has seldom been reported. To report the implementation of digital imaging in ocular screening of all newborns in multiple centres in China and to describe the abnormal findings of fundus examination, we did the cross-sectional study. METHODS: Fundus examinations were performed on newborns within the 42 days after birth using a RetCam wide-field digital imaging system. Digital images of the posterior pole, superior, nasal and temporal retinal fields of each participant were taken...
August 17, 2018: British Journal of Ophthalmology
Lorenzo Marconi, Ben Challacombe
The advantages of using the retroperitoneal approach in posterior and lateral masses are the familiarity and increased experience of the robotic surgeon with the nuances of this approach, which will ultimately benefit patients for whom that technique is imperative.
August 14, 2018: European Urology Focus
L Pirazzoli, S Lloyd-Fox, R Braukmann, M H Johnson, T Gliga
In adults, affective touch leads to widespread activation of cortical areas including posterior Superior Temporal Sulcus (pSTS) and Inferior Frontal Gyrus (IFG). Using functional Near Infrared Spectroscopy (fNIRS), we asked whether similar areas are activated in 5-month-old infants, by comparing affective to non-affective touch. We contrasted a human touch stroke to strokes performed with a cold metallic spoon. The hypothesis that adult-like activation of cortical areas would be seen only in response to the human touch stroke was not confirmed...
July 5, 2018: Developmental Cognitive Neuroscience
Nam-Su Chung, Han-Dong Lee, Chang-Hoon Jeon
BACKGROUND: In oblique lateral interbody fusion (OLIF), the lateral cage enters into the disc space obliquely, and is then turned to the true lateral direction to achieve a lateral lumbar interbody fusion. The OLIF cage is sometimes placed asymmetrically although it seemed to be placed accurately on intraoperative C-arm images. The present study aimed to investigate the accuracy of cage placement and its effect on the radiological outcome in OLIF. METHODS: This study involved a retrospective radiological analysis of 127 lateral cages in 75 consecutive OLIF patients...
August 14, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
G Delvecchio, M G Rossetti, E Caletti, A Arighi, D Galimberti, P Basilico, M Mercurio, R A Paoli, C Cinnante, F Triulzi, A C Altamura, E Scarpini, P Brambilla
BACKGROUND: Somatoform Disorders (SD) are a heterogeneous group of psychiatric syndromes characterized by common symptoms, which may mimic a physical condition but they are not explained by a medical condition. Although the biologic nature of this disorder has been widely accepted, the neuroanatomical correlates characterizing SD are still inconclusive. Therefore, this study aims to explore gray matter (GM) volume alterations in SD patients compared to healthy controls and their possible association with clinical and cognitive measures...
July 20, 2018: Psychosomatics
Crystal Sin Yi Cheung, Adam Jekielek, Nupura Bakshi, Rajeev Muni, Filberto Altomare, Louise Giavedoni, Alan Berger, Larissa M Matukas, David Wong, Larissa Derzko-Dzulynsky
OBJECTIVE: To assess the clinical findings and microbiology investigations in patients with suspected infectious posterior segment uveitis (PSU). DESIGN: Retrospective case study. METHODS: Between January and December 2014, medical records of 270 patients with PSU were reviewed. Baseline ocular examination, presumed and final diagnoses, microbiology investigations from aqueous or vitreous fluid, and peripheral blood were reviewed. RESULTS: Infectious PSU was suspected in 28 patients among 270 PSU cases (10...
August 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Chen Hu, Weimin Lin, Ting Gong, Yi Zuo, Yili Qu, Yi Man
PURPOSE: To compare hard- and soft-tissue changes around immediate implants connected with 2 types of healing abutments during the early phases of healing. MATERIALS AND METHODS: Twenty-eight immediate implants were placed into molar/premolar sockets through a modified osteotomy method. The gaps around implants were grafted with deproteinized bovine bone mineral. According to the size of the alveoli, the implants were connected with titanium healing abutments (traditional group) or customized healing abutments (CA group)...
August 15, 2018: Implant Dentistry
Faizan Ahmad, Ra J Prabhu, Jun Liao, Shwe Soe, Michael D Jones, Jonathan Miller, Parker Berthelson, Daniel Enge, Katherine M Copeland, Samar Shaabeth, Richard Johnston, Ian Maconochie, Peter S Theobald
Neonatal heart disorders represent a major clinical challenge, with congenital heart disease alone affecting 36,000 new-borns annually within the European Union. Surgical intervention to restore normal function includes the implantation of synthetic and biological materials; however, a lack of experimental data describing the mechanical behaviour of neonatal cardiac tissue is likely to contribute to the relatively poor short- and long-term outcome of these implants. This study focused on characterising the mechanical behaviour of neonatal cardiac tissue using a porcine model, to enhance the understanding of how this differs to the equivalent mature tissue...
July 29, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Chunliang Feng, Xinyuan Yan, Wenhao Huang, Shihui Han, Yina Ma
Self-concept consists of self-identity that distinguishes self from other people and knowledge that describes one's own attributes in different dimensions. Because self-concept plays a fundamental role in individuals' social functioning and mental health, behavioral studies have examined cognitive processes of self-identity and self-knowledge extensively. Nevertheless, how different dimensions of the self-concept are organized in multi-voxel neural patterns remains elusive. Here, we address this issue by employing representational similarity analyses of behavioral/theoretical models of multidimensional self-representation and blood oxygen level dependent responses, recorded using functional MRI, to judgments of personality traits, physical attributes and social roles of oneself, a close (one's mother) other, and a distant (celebrity) other...
August 14, 2018: NeuroImage
Samantha M Bradford, Eric R Mikula, Tibor Juhasz, Donald J Brown, James Jester
The purpose of this study was to measure collagen fiber crimping (CFC) using nonlinear optical imaging of second harmonic generated (SHG) signals to determine the effects of UVA-riboflavin induced corneal collagen crosslinking (UVA CXL) on collagen structure. Two groups, four rabbits each, were treated in the right eye with standard UVA CXL. In vivo confocal microscopy was performed at 1, 2, and 4 weeks after treatment for the first group and up to three months for the second group to measure epithelial/stromal thickness and corneal haze during recovery...
August 14, 2018: Experimental Eye Research
Mark F Coughlan, Alexander V Goncharov
We present a method for determining the deformable mirror profile to simulate the optical effect of a customized contact lens in the central visual field. Using nonpupil-conjugated adaptive optics allows a wider field simulation compared to traditional pupil-conjugated adaptive optics. For a given contact lens, the mirror shape can be derived analytically using Fermat's principle of the stationary optical path or numerically using optimization in ray-tracing programs. An example of an aspheric contact lens simulation is given to illustrate the method, and the effect of eye misalignment with respect to the deformable mirror position is investigated...
August 1, 2018: Applied Optics
Mladen Djurasovic, Katlyn E McGraw, Kelly Bratcher, Charles H Crawford, John R Dimar, Rolando M Puno, Steven D Glassman, R Kirk Owens, Leah Y Carreon
OBJECTIVE The goal of this study was to determine efficacy and cost-effectiveness of Cell Saver in 2- and 3-level lumbar decompression and fusion. METHODS Patients seen at a tertiary care spine center who were undergoing a posterior 2- or 3-level lumbar decompression and fusion were randomized to have Cell Saver used during their surgery (CS group, n = 48) or not used (No Cell Saver [NCS] group, n = 47). Data regarding preoperative and postoperative hemoglobin and hematocrit, estimated blood loss, volume of Cell Saver blood reinfused, number of units and volume of allogeneic blood transfused intraoperatively and postoperatively, complications, and costs were collected...
August 17, 2018: Journal of Neurosurgery. Spine
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