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https://www.readbyqxmd.com/read/28635363/early-mortality-risk-in-incident-chinese-hemodialysis-patients-a-retrospective-cohort-study
#1
Xinju Zhao, Mei Wang, Li Zuo
BACKGROUND: Early mortality risk of maintenance hemodialysis (MHD) patients varies by country and ethnicity. Here, early mortality in incident Chinese HD patients were studied. METHODS: Data from 1 January 2007 to 31 December 2013 were pulled from Beijing dialysis registry system. All included patients were followed to the end of 2013. This time period of dialysis was divided into six intervals (≤120, 121-365 days; 1-2, 2-3, 3-4, ≥5 years). Patients' demographics, primary cause of end-stage renal disease (ESRD), date of first HD, date of death, cause for death, date and cause of censoring were extracted from the registry database...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28632927/prospective-associations-between-environmental-heavy-metal-exposure-and-renal-outcomes-in-adults-with-chronic-kidney-disease
#2
Chun-Chieh Tsai, Chia-Lin Wu, Chew-Teng Kor, Ie-Bin Lian, Chin-Hua Chang, Teng-Hsiang Chang, Chia-Chu Chang, Ping-Fang Chiu
BACKGROUND: In Taiwan, Changhua County residents were exposed to high heavy metal pollution and exhibited high heavy metal levels in blood and urine. We examined associations between heavy metals in residential soil and renal outcomes of residents with chronic kidney disease (CKD). METHOD: From January 01, 2003 to June 30, 2015, we retrospectively identified CKD patients with an estimated glomerular filtration rate of <60 mL/min/1.73 m(2) at one tertiary care center...
June 20, 2017: Nephrology
https://www.readbyqxmd.com/read/28623895/effects-of-home-based-exercise-on-pre-dialysis-chronic-kidney-disease-patients-a-randomized-pilot-and-feasibility-trial
#3
Koji Hiraki, Yugo Shibagaki, Kazuhiro P Izawa, Chiharu Hotta, Akiko Wakamiya, Tsutomu Sakurada, Takashi Yasuda, Kenjiro Kimura
BACKGROUND: Only a few research is available on the effects of home-based exercise training on pre-dialysis chronic kidney disease (CKD) patients. Therefore, we aimed to elucidate the effect of home-based exercise therapy on kidney function and arm and leg muscle strength in pre-dialysis CKD patients. METHODS: Thirty-six male stage 3-4 pre-dialysis CKD patients (age, 68.7 ± 6.8 years; estimated glomerular filtration rate (eGFR), 39.0 ± 11.6 ml/min/1.73 m(2)) who were being treated as outpatients were included...
June 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28621826/cerebral-metabolic-alterations-and-cognitive-dysfunction-in-children-with-chronic-kidney-disease-using-magnetic-resonance-spectroscopy-and-wechsler-intelligence-scale
#4
Doaa Mohammed Youssef, Ahmed Hosny Mohamed, Wafaa Mahmoud Kamel Attia, Faten Fawzy Mohammad, Nelly Rafaat Abd El Fatah, Amal Saeed Elshal
BACKGROUND: Many studies described Impaired intelligence, attention, memory and executive function in patients with chronic kidney disease (CKD) dialyzed and non-dialyzed, but there is still lacking the early and sensitive method of detection of these deficits. The purpose of this study is to investigate relation between the brain metabolic alteration [measured by magnetic resonance spectroscopy (MRS)] and cognitive dysfunction in CKD children (detected by psychometric analysis). SUBJECTS AND METHODS: One hundred and forty patients with CKD were included [ 40 patients with stage 5 CKD on dialysis, 30 patients with stage 4 to 5 CKD without dialysis, and 70 patients with stage 1 to 3 CKD]...
June 16, 2017: Nephrology
https://www.readbyqxmd.com/read/28612028/chronic-kidney-dysfunction-can-increase-the-risk-of-deep-vein-thrombosis-after-total-hip-and-knee-arthroplasty
#5
Qiangqiang Li, Bingyang Dai, Yao Yao, Kai Song, Dongyang Chen, Qing Jiang
BACKGROUND: Deep vein thrombosis (DVT) is one of the major complications of total joint arthroplasty (TJA). Chronic kidney dysfunction (CKD) has proven to promote a proinflammatory and prothrombotic state and is prevalent among patients undergoing TJA. The purpose of this study is to identify whether CKD increase the risk of DVT following TJA. METHODS: In a retrospective study, 1274 patients who underwent primary TJA were studied. CKD is graded in 5 stages. Univariate and multivariate analysis were used to identify the association of CKD and its severity with postoperative DVT...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28609449/development-of-next-generation-sequencing-panel-for-umod-and-association-with-kidney-disease
#6
Caitlin Bailie, Jill Kilner, Alexander P Maxwell, Amy Jayne McKnight
Chronic kidney disease (CKD) has a prevalence of approximately 10% in adult populations. CKD can progress to end-stage renal disease (ESRD) and this is usually fatal unless some form of renal replacement therapy (chronic dialysis or renal transplantation) is provided. There is an inherited predisposition to CKD with several genetic risk markers now identified. The UMOD gene has been associated with CKD of varying aetiologies. An AmpliSeq next generation sequencing panel was developed to facilitate comprehensive sequencing of the UMOD gene, covering exonic and regulatory regions...
2017: PloS One
https://www.readbyqxmd.com/read/28602899/renal-salvage-with-renal-artery-stenting-improves-long-term-survival
#7
J Gregory Modrall, Clayton Trimmer, Shirling Tsai, Melissa L Kirkwood, Mujtaba Ali, John E Rectenwald, Carlos H Timaran, Eric B Rosero
BACKGROUND: The Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) Trial cast doubt on the benefits of renal artery stenting. However, the outcomes for patients with chronic kidney disease (CKD) were not analyzed separately in the CORAL Trial. We hypothesized that patients who experienced a significant improvement in renal function after renal artery stenting (RAS) would have improved long-term survival, compared to patients whose renal function was not improved by stenting...
June 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28601120/measurement-of-breath-ammonia-for-detection-of-patients-with-chronic-kidney-disease
#8
Sebastjan Bevc, Eva Mohorko, Mitja Kolar, Polona Brglez, Andrej Holobar, Daniela Kniepeiss, Matej Podbregar, Nejc Piko, Nina Hojs, Maša Knehtl, Robert Ekart, Radovan Hojs
BACKGROUND: In a healthy individual, ammonia is converted to urea in the liver. Urea is then transported through the bloodstream and then excreted into the urine by the kidneys. In patients with chronic kidney disease (CKD), the accumulated urea is degraded by salivary urease into ammonia, which is then excreted by breathing. Breath ammonia can therefore be used for detecting the increased nitrogen-bearing wastes. In our pilot study, an electrochemical sensor was used to measure and analyze breath ammonia in healthy volunteers and patients with CKD...
June 9, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28599901/esrd-after-heart-failure-myocardial-infarction-or-stroke-in-type%C3%A2-2-diabetic-patients-with-ckd
#9
David M Charytan, Scott D Solomon, Peter Ivanovich, Giuseppe Remuzzi, Mark E Cooper, Janet B McGill, Hans-Henrik Parving, Patrick Parfrey, Ajay K Singh, Emmanuel A Burdmann, Andrew S Levey, Dick de Zeeuw, Kai-Uwe Eckardt, John J V McMurray, Brian Claggett, Eldrin F Lewis, Marc A Pfeffer
BACKGROUND: How cardiovascular (CV) events affect progression to end-stage renal disease (ESRD), particularly in the setting of type 2 diabetes, remains uncertain. STUDY DESIGN: Observational study. SETTING & PARTICIPANTS: 4,022 patients with type 2 diabetes, anemia, and chronic kidney disease from the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). PREDICTOR: Postrandomization CV events. OUTCOMES: ESRD (defined as initiation of dialysis for >30 days, kidney transplantation, or refusal or nonavailability of renal replacement therapy) and post-ESRD mortality within 30 days and during overall follow-up after an intercurrent CV event...
June 6, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28597784/the-impact-of-non-dipper-circadian-rhythm-of-blood-pressure-on-left-ventricular-hypertrophy-in-patients-with-non-dialysis-chronic-kidney-disease
#10
Xiajing Che, Shan Mou, Weiming Zhang, Minfang Zhang, Leyi Gu, Yucheng Yan, Hua Ying, Chunhua Hu, Jiaqi Qian, Zhaohui Ni
Objective The aim of this study was to investigate the correlation between non-dipper circadian rhythm of blood pressure (BP) and left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD). Methods and results All 257 patients with stage 1 to 5 CKD were enrolled in the study and classified into a CKD1-3 group and a CKD4-5 group according to renal function. The parameters and circadian rhythm of BP were measured by a GE Marquette Tonoport V Eng dynamic sphygmomanometer, and cardiac structure was examined by echocardiography...
April 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28593895/congenital-anomalies-of-the-kidney-and-urinary-tract-in-children-born-small-for-gestational-age
#11
Aleksandra Janchevska, Zoran Gucev, L Tasevska-Rmus, Velibor Tasic
INTRODUCTION: Congenital anomalies of the kidney and urinary tract (CAKUT) represent several types of malformations with occurrence of 1 in about 500 live births. OBJECTIVE: Small for gestation age (SGA) may influence in prevalence of CAKUT and progression of chronic kidney disease (CKD) in children. The aim of this study was to elaborate our experiences with detected CAKUT in a cohort of SGA born children in Macedonia. METHODS: Our cohort consisted of 100 SGA born children investigated for associated congenital anomalies of urinary tract...
March 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28592280/white-blood-cell-count-predicts-the-odds-of-kidney-function-decline-in-a-chinese-community-based-population
#12
Fangfang Fan, Jia Jia, Jianping Li, Yong Huo, Yan Zhang
BACKGROUND: Inflammatory processes are very important in the development of kidney disease. Nevertheless, the association between white blood cell (WBC) count and the risk of renal dysfunction has not been well-established, especially in subjects without chronic kidney disease (CKD). Our study investigated the association between WBC count and kidney function decline in a Chinese community-based population with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m(2)...
June 7, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28592243/reduced-kidney-function-albuminuria-and-risks-for-all-cause-and-cardiovascular-mortality-in-china-a-population-based-cohort-study
#13
Jinwei Wang, Fang Wang, Shiwei Liu, Maigeng Zhou, Luxia Zhang, Minghui Zhao
BACKGROUND: Previous studies have indicated that reduced kidney function and albuminuria are associated with increased risk of mortality and adverse cardiovascular outcomes, however, the evidence from the Asian population is limited. We investigated the association between the indicators of chronic kidney disease (CKD) and all-cause mortality, as well as cardiovascular mortality among a general population in China. METHODS: We conducted an observational study among 47,204 Chinese adults, from a cross-sectional survey, whose survival status is identified through December 31, 2013...
June 7, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28583561/investigating-serum-uric-acid-as-a-risk-factor-in-the-development-of-delayed-renal-recovery-in-living-kidney-donors
#14
R C Bravo, M B Gamo, H H Lee, Y E Yoon, W K Han
BACKGROUND: Hyperuricemia has been associated with kidney disease and remains controversial with regard to its gender-specific differences and impact in living kidney donation. METHODS: Between 2006 and 2015, charts of live kidney donors who underwent nephrectomy and had a minimum follow-up of 1 year were reviewed. A total of 291 donors were included and divided based on gender-specific pre-donation serum uric acid (SUA) tertiles. Renal functional outcomes included were estimated glomerular filtration rate (eGFR) at 6-month and 1-year follow-up and percentage of donors with a 1-year eGFR <60 mL/min/1...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28577854/diabetes-with-early-kidney-involvement-may-shorten-life-expectancy-by-16-years
#15
Chi Pang Wen, Chia Hsuin Chang, Min Kuang Tsai, June Han Lee, Po Jung Lu, Shan Pou Tsai, Christopher Wen, Chien Hua Chen, Chih Wen Kao, Chwen Keng Tsao, Xifeng Wu
This study aimed to identify the excess risks associated with diabetic patients with early kidney involvement (early diabetic kidney disease). The mortality risks of early diabetic kidney disease, defined as diabetes in early stages 1-3 chronic kidney disease (CKD), were assessed from a cohort of 512,700 adults in Taiwan participating in a health surveillance program from 1994-2008. Three related groups were identified and compared: diabetes without CKD, early diabetic kidney disease, and early CKD without diabetes...
June 1, 2017: Kidney International
https://www.readbyqxmd.com/read/28576889/blood-coagulation-system-in-patients-with-chronic-kidney-disease-a-prospective-observational-study
#16
Meng-Jie Huang, Ri-Bao Wei, Yang Wang, Ting-Yu Su, Ping Di, Qing-Ping Li, Xi Yang, Ping Li, Xiang-Mei Chen
OBJECTIVES: Thromboembolic events are the major factor affecting the prognosis of patients with chronic kidney disease (CKD). Haemostatic alterations are possible causes of these complications, but their roles remain poorly characterised. In the prospective observational study, we investigated the entire coagulation process in patients with CKD to elucidate the mechanisms of their high thromboembolic risk. METHODS: A total of 95 patients with CKD and 20 healthy controls who met the inclusion criteria were consecutively recruited from September 2015 to March 2016...
June 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28576851/urinary-tamm-horsfall-protein-albumin-vitamin-d-binding-protein-and-retinol-binding-protein-as-early-biomarkers-of-chronic-kidney-disease-in-dogs
#17
Fernanda Chacar, Márcia Kogika, Talita R Sanches, Douglas Caragelasco, Cínthia Martorelli, Camila Rodrigues, Jose Manuel C Capcha, Dennis Chew, Lúcia Andrade
Proteinuria is a marker and mediator of chronic kidney disease (CKD). In clinical practice, the urinary protein-to-creatinine ratio (UP/C) is of limited usefulness, because it indicates only the magnitude of proteinuria and not the origin of the loss (glomerular or tubular). The complete assessment of proteinuria includes quantitative and qualitative evaluations, both of which are required in order to optimize the therapy. In addition to measuring the UP/C, we performed SDS-PAGE and western blotting to determine the expression of albumin, vitamin D-binding protein (VDBP), retinol-binding protein (RBP), and Tamm-Horsfall protein (THP) in urine samples of 49 dogs: healthy (control) dogs (n = 9); and dogs with CKD (n = 40), stratified by stage...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28573489/ultrasonic-evaluation-of-renal-cortex-arterial-area-enables-differentiation-between-hypertensive-and-glomerulonephritis-related-chronic-kidney-disease
#18
Arkadiusz Lubas, Grzegorz Kade, Robert Ryczek, Piotr Banasiak, Przemysław Dyrla, Katarzyna Szamotulska, Daniel Schneditz, Stanisław Niemczyk
PURPOSE: Identifying the primary etiology of cardio-renal syndrome in a timely manner remains an ongoing challenge in nephrology. We hypothesized that hypertensive kidney damage can be distinguished from chronic glomerulonephritis at an early stage of chronic kidney disease (CKD) using ultrasound (US) Doppler sonography. METHODS: Fifty-six males (age 54 ± 15, BMI 28.3 ± 3.5 kg/m(2)) with hypertension and stable CKD at stages 2-4 [38 with essential hypertension (HT-CKD); 18 with glomerulonephritis (GN-CKD)] were studied...
June 1, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28572892/relationship-between-chronic-kidney-disease-and-depression-in-elderly-koreans-using-the-2013-korea-national-health-and-nutrition-examination-survey-data
#19
Ji Woon Kim, Sung Jin Moon, Hyun Ja Kim, Dae Geun Lee
BACKGROUND: Depression is prevalent in patients with chronic kidney disease (CKD) and continues to increase in elderly adults. Therefore, the aim of our study was to examine the relationship between CKD and depression in older patients. METHODS: We conducted a cross-sectional study based on 2013 Korea National Health and Nutrition Examination Survey data. In total, data of 973 subjects aged ≥65 years were analyzed, and the estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation...
May 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/28572883/impact-of-creatinine-methodology-on-glomerular-filtration-rate-estimation-in-diabetes
#20
Marijana Vučić Lovrenčić, Vanja Radišić Biljak, Kristina Blaslov, Sandra Božičević, Lea Smirčić Duvnjak
AIM: To evaluate the influence of creatinine methodology on the performance of chronic kidney disease (CKD)-Epidemiology Collaboration Group-calculated estimated glomerular filtration rate (CKD-EPI-eGFR) for CKD diagnosis/staging in a large cohort of diabetic patients. METHODS: Fasting blood samples were taken from diabetic patients attending our clinic for their regular annual examination, including laboratory measurement of serum creatinine and eGFR. RESULTS: Our results indicated an overall excellent agreement in CKD staging (kappa = 0...
May 15, 2017: World Journal of Diabetes
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