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https://www.readbyqxmd.com/read/30318260/pharmacological-treatments-of-neuropathic-pain-the-latest-recommendations
#1
REVIEW
N Attal
We provide an up-to-date review of the pharmacological treatment of neuropathic pain with emphasis on the latest evidence-based recommendations for its pharmacological treatment. Drugs proposed as first line include tricyclic antidepressants (particularly amitriptyline), serotonin-norepinephrine reuptake inhibitors (particularly duloxetine), pregabalin and gabapentin. Second line treatments include lidocaine plasters and capsaicin high concentration patches for peripheral neuropathic pain only, and tramadol...
October 11, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/30306307/-postherpetic-neuralgia-of-the-left-trigeminus-nerve-v1-successful-therapy-with-capsaicin-8-patch
#2
K-U Kern, M Schwickert-Nieswandt
A 68-year-old patient suffered from postzoster neuralgia with severe pain of the left trigeminal nerve V1. Despite medication with gabapentin 1800 mg/d, oxacarbazepine 600 mg, tapentadol 500 mg/d, amitriptyline 20 mg as well as ambroxol 20% ointment and lidocaine patch topically, the pain reached an intensity of 8-10 on the numeric rating scale (NRS). Wearing a CPAP (continuous positive airway pressure) mask at night to treat a sleep apnea was impossible or the mask was leaking under lidocaine patch, only topical ambroxol 20% brought a certain pain relief...
October 10, 2018: Der Schmerz
https://www.readbyqxmd.com/read/30278568/the-use-of-5-lidocaine-medicated-plaster-for-acute-postoperative-pain-after-gynecological-surgery-a-pilot-randomized-controlled-feasibility-trial
#3
RANDOMIZED CONTROLLED TRIAL
Lydia Ln Lau, Cheuk Yin Li, Anna Lee, Simon Kc Chan
OBJECTIVES: To examine the feasibility and potential efficacy of 5% lidocaine medicated plaster for acute postoperative pain in a parallel, blinded, randomized controlled pilot trial. METHODS: Twenty-eight women undergoing elective gynecological surgery with midline incisions were randomly allocated 5% lidocaine medicated patch (Lignopad) or placebo plasters. Postoperative pain at rest and on movement at 24 hours were the primary study endpoints, with secondary endpoints of postoperative pain within the first 48 hours, cumulative morphine consumption (mg), predicted peak flow rate (PFR) (%) and adverse effects...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30252425/mechanical-low-back-pain
#4
Joshua Scott Will, David C Bury, John A Miller
Low back pain is usually nonspecific or mechanical. Mechanical low back pain arises intrinsically from the spine, intervertebral disks, or surrounding soft tissues. Clinical clues, or red flags, may help identify cases of nonmechanical low back pain and prompt further evaluation or imaging. Red flags include progressive motor or sensory loss, new urinary retention or overflow incontinence, history of cancer, recent invasive spinal procedure, and significant trauma relative to age. Imaging on initial presentation should be reserved for when there is suspicion for cauda equina syndrome, malignancy, fracture, or infection...
October 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/30175446/effect-of-5-transdermal-lidocaine-patches-on-postoperative-analgesia-in-dogs-undergoing-hemilaminectomy
#5
V Re Bravo, F Aprea, R J Bhalla, C De Gennaro, G B Cherubini, F Corletto, E Vettorato
OBJECTIVES: To investigate the effect of 5% lidocaine patches on postoperative analgesia in dogs undergoing hemilaminectomy. MATERIALS AND METHODS: Client-owned dogs undergoing hemilaminectomy for a single acute intervertebral thoracolumbar disc extrusion were enrolled in this prospective, randomised, blinded clinical trial. Following methadone administration, anaesthesia was induced with propofol, and maintained with isoflurane in oxygen and fentanyl infusion, in both groups...
September 2, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/30099632/loss-of-function-of-nav1-8-d1639n-linked-to-human-pain-can-be-rescued-by-lidocaine
#6
Luisa Kaluza, Jannis E Meents, Martin Hampl, Corinna Rösseler, Petra A I Hautvast, Silvia Detro-Dassen, Ralf Hausmann, Günther Schmalzing, Angelika Lampert
Mutations in voltage-gated sodium channels are associated with altered pain perception in humans. Most of these mutations studied to date present with a direct and intuitive link between the altered electrophysiological function of the channel and the phenotype of the patient. In this study, we characterize a variant of Nav1.8, D1639N, which has been previously identified in a patient suffering from the chronic pain syndrome "small fiber neuropathy". Using a heterologous expression system and patch-clamp analysis, we show that Nav1...
August 11, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30066214/the-prescription-of-lidocaine-patches-in-osteoarthritis-a-complete-audit-cycle
#7
Rosie Mc Colgan, David M Dalton, Hugh P O'Sullivan, James A Sproule
OBJECTIVES: Nationally, 5% of the population have been prescribed topical lidocaine patches (TLPs). These patches cost €77-230 per month. The only licensed indication for TLP is post-herpetic neuralgia (PHN). It has not proven to be effective for any other indication including musculoskeletal and post-surgical pain. It is estimated that only 5-10% of patients on TLP have PHN. The aim of this study was to audit the number of inpatients currently prescribed TLP-appropriately and inappropriately-and to examine the prescribing patterns...
July 31, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29988901/transient-complete-visual-loss-and-subsequent-cystoid-macular-edema-after-intracameral-lidocaine-injection-following-uneventful-cataract-surgery
#8
Mehrdad Mohammadpour, Hamid Riazi-Esfahani
Purpose: To report a case of transient visual loss following uncomplicated cataract surgery with unpreserved intracameral lidocaine. Methods: A 61-year-old woman with nuclear sclerosis cataract underwent uncomplicated phacoemulsification and in-the-bag intraocular lens (IOL) implantation. Results: After opening the eye patch on the first postoperative day, the patient complained of complete blindness. Her vision was no light perception (NLP) and the Marcus-Gunn was found to be 4+...
June 2018: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/29913873/postherpetic-neuralgia-new-hopes-in-prevention-with-adult-vaccination-and-in-treatment-with-a-concentrated-capsaicin-patch
#9
Ewa Gawecka, Oddbjørn Viken
Background and purpose Postherpetic neuralgia (PHN) is a complication of acute herpes zoster (HZ). The evidence base for management of PHN has increased by recent publications. Therefore, we reviewed incidence of HZ, prevalence, risk factors, and mechanism of PHN pain, prevention and treatment of PHN with special interest in studies on adult vaccination and topical application of lidocaine and concentrated capsaicin patch. Methods We searched databases with an English language restriction: MEDLINE 1944-2011, EMBASE 1988-2011, PubMed, and the Cochrane Controlled Trial Register and Cochrane Library (2011)...
October 1, 2012: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29794759/comparison-of-the-effectiveness-in-pain-reduction-and-pulmonary-function-between-a-rib-splint-constructed-in-the-er-and-a-manufactured-rib-splint
#10
RANDOMIZED CONTROLLED TRIAL
Yoonje Lee, Sang-Hyun Lee, Changsun Kim, Hyuk Joong Choi
BACKGROUND: In the treatment of patients with rib fractures (RFs), pain reduction is the most important consideration. Various studies have examined the effectiveness of treatments administered to RF patients, such as lidocaine patches, IV drugs, nerve blockers, and surgery. In this study, we evaluated the difference in the effectiveness in pain reduction between 2 groups of RF patients: 1 group who received a rib splint constructed in the ER (ER splint) and another group who received a Chrisofix Chest Orthosis (CCO) manufactured rib splint...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29706996/does-the-use-of-nitroglycerin-patch-improve-local-anaesthetic-effects-in-bier-s-block-a-double-blind-placebo-controlled-study
#11
Ahmed Said Elgebaly
Aim: The aim of the study was to assess the nitroglycerin patch as a new additive to Bier's block and its impact on the effects and dose of lidocaine. Methods: Forty patients of each sex belonging to ASA I or II underwent elective tendon repair surgeries of the forearm and hand. The patients were divided into two equal groups as follows: Group C received only lidocaine (1.5 mg/kg, 0.25%) and Group N received lidocaine (1.5 mg/kg, 0.25%) + 5 mg transcutaneous nitroglycerin patch...
2018: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/29672324/lidocaine-patch-to-treat-postoperative-tourniquet-pain-after-total-knee-replacement-a-case-report
#12
Brittney M Clark, Gabriel L Pagani-Estevez, Rebecca L Johnson
Intraoperative tourniquet-related pain is well recognized by anesthesiologists, but postoperative tourniquet-related pain has received little attention. We present a patient who underwent a total knee arthroplasty under general anesthesia and an adductor canal nerve block. She complained of intractable thigh pain postoperatively. Lidocaine 5% patches completely resolved her postoperative tourniquet-related pain.
October 1, 2018: A&A practice
https://www.readbyqxmd.com/read/29562618/transdermal-and-topical-drug-administration-in-the-treatment-of-pain
#13
REVIEW
Wojciech Leppert, Malgorzata Malec-Milewska, Renata Zajaczkowska, Jerzy Wordliczek
The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients' age, comorbidities, and appropriate choice of analgesic, its dose and route of administration. This review is aimed at presenting current knowledge on analgesics administered by transdermal and topical routes for physicians, nurses, pharmacists, and other health care professionals dealing with patients suffering from pain. Analgesics administered transdermally or topically act through different mechanisms...
March 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29553987/chronic-postsurgical-pain-and-cancer-the-catch-of-surviving-the-unsurvivable
#14
Stephen R Humble, Nicolas Varela, Asantha Jayaweera, Arun Bhaskar
PURPOSE OF REVIEW: Chronic postsurgical pain (CPSP) is an important and well recognized cause of much long-term suffering, which in some cases may be preventable and affects many people living with cancer. Unfortunately, general consensus is lacking as to how best reduce the risk of developing CPSP. RECENT FINDINGS: Cancer is now not always a short-lived, fatal disease and is now moving towards a chronic illness. Poorly managed perioperative pain is the greatest risk factor for CPSP...
June 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29509584/sodium-channel-nav1-3-is-expressed-by-polymorphonuclear-neutrophils-during-mouse-heart-and-kidney-ischemia-in-vivo-and-regulates-adhesion-transmigration-and-chemotaxis-of-human-and-mouse-neutrophils-in-vitro
#15
Marit Poffers, Nathalie Bühne, Christine Herzog, Anja Thorenz, Rongjun Chen, Faikah Güler, Axel Hage, Andreas Leffler, Frank Echtermeyer
BACKGROUND: Voltage-gated sodium channels generate action potentials in excitable cells, but they have also been attributed noncanonical roles in nonexcitable cells. We hypothesize that voltage-gated sodium channels play a functional role during extravasation of neutrophils. METHODS: Expression of voltage-gated sodium channels was analyzed by polymerase chain reaction. Distribution of Nav1.3 was determined by immunofluorescence and flow cytometry in mouse models of ischemic heart and kidney injury...
June 2018: Anesthesiology
https://www.readbyqxmd.com/read/29415859/effects-of-transdermal-lidocaine-or-lidocaine-with-prilocaine-or-tetracaine-on-mechanical-superficial-sensation-and-nociceptive-thermal-thresholds-in-horses
#16
RANDOMIZED CONTROLLED TRIAL
Franz J Söbbeler, Sabine Br Kästner
OBJECTIVE: To evaluate the transdermal local anaesthetic effect of lidocaine or lidocaine combined with prilocaine or tetracaine in horses. STUDY DESIGN: Experimental, randomized study. ANIMALS: A total of five healthy adult warmblood horses. METHODS: Horses were clipped bilaterally at the withers, cranial saddle area and caudal saddle area. Baseline measurements for mechanical superficial sensation via von Frey filaments and nociceptive thermal thresholds were performed...
March 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29251644/pharmacodynamics-and-pharmacokinetics-of-lidocaine-in-a-rodent-model-of-diabetic-neuropathy
#17
Werner Ten Hoope, Markus W Hollmann, Kora de Bruin, Hein J Verberne, Arie O Verkerk, Hanno L Tan, Camiel Verhamme, Janneke Horn, Marcel Rigaud, Susanne Picardi, Philipp Lirk
BACKGROUND: Clinical and experimental data show that peripheral nerve blocks last longer in the presence of diabetic neuropathy. This may occur because diabetic nerve fibers are more sensitive to local anesthetics or because the local anesthetic concentration decreases more slowly in the diabetic nerve. The aim of this study was to investigate both hypotheses in a rodent model of neuropathy secondary to type 2 diabetes. METHODS: We performed a series of sciatic nerve block experiments in 25 Zucker Diabetic Fatty rats aged 20 weeks with a neuropathy component confirmed by neurophysiology and control rats...
March 2018: Anesthesiology
https://www.readbyqxmd.com/read/29141003/trpa1-and-trpv1-are-required-for-lidocaine-evoked-calcium-influx-and-neuropeptide-release-but-not-cytotoxicity-in-mouse-sensory-neurons
#18
Mirjam Eberhardt, Thomas Stueber, Jeanne de la Roche, Christine Herzog, Andreas Leffler, Peter W Reeh, Katrin Kistner
BACKGROUND: Local anaesthetics (LA) reduce neuronal excitability by inhibiting voltage-gated Na+ channels. When applied at high concentrations in the direct vicinity of nerves, LAs can also induce relevant irritation and neurotoxicity via mechanisms involving an increase of intracellular Ca2+. In the present study we explored the role of the Ca2+-permeable ion channels TRPA1 and TRPV1 for lidocaine-induced Ca2+-influx, neuropeptide release and neurotoxicity in mouse sensory neurons. METHODS: Cultured dorsal root ganglion (DRG) neurons from wildtype and mutant mice lacking TRPV1, TRPA1 or both channels were explored by means of calcium imaging, whole-cell patch clamp recordings and trypan blue staining for cell death...
2017: PloS One
https://www.readbyqxmd.com/read/29135709/pilot-study-comparing-topical-anesthetic-agents-in-pterygium-surgery-subconjunctival-injection-versus-2-lidocaine-gel-versus-5-lidocaine-gel
#19
RANDOMIZED CONTROLLED TRIAL
Felipe Pereira, Hélio Francisco Shiroma, Muller Gonçalves Urias, Verônica Haysa Yamada, Acácio Alves de Souza Lima, Ana Luisa Hofling-Lima, Michel Eid Farah, Eduardo Buchele Rodrigues
PURPOSE: To compare the efficacy of different concentrations of topical lidocaine gel with standard subconjunctival anesthesia. METHODS: This was a prospective randomized controlled pilot study with 3 different groups. Group SC received subconjunctival lidocaine and proparacaine drops as needed during surgery. Group L2 received 2% lidocaine gel and group L5 received 5% lidocaine gel. Both lidocaine gel groups could receive another gel dose as needed during the procedure...
February 2018: Cornea
https://www.readbyqxmd.com/read/29128504/biophysical-comparison-of-sodium-currents-in-native-cardiac-myocytes-and-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#20
Robert J Goodrow, Suveer Desai, Jacqueline A Treat, Brian K Panama, Mayurika Desai, Vladislav V Nesterenko, Jonathan M Cordeiro
INTRODUCTION: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are used for safety pharmacology and to investigate genetic diseases affecting cardiac ion channels. It is unclear whether adult myocytes or hiPSC-CMs are the better platform for cardiac safety pharmacology. We examined the biophysical and molecular properties of INa in adult myocytes and hiPSC-CMs. METHODS: hiPSC-CMs were plated at low density. Atrial and ventricular cells were obtained from dog hearts...
March 2018: Journal of Pharmacological and Toxicological Methods
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