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Lidocaine patch

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https://www.readbyqxmd.com/read/30099632/loss-of-function-of-nav1-8-d1639n-linked-to-human-pain-can-be-rescued-by-lidocaine
#1
Luisa Kaluza, Jannis E Meents, Martin Hampl, Corinna Rösseler, Petra A I Hautvast, Silvia Detro-Dassen, Ralf Hausmann, Günther Schmalzing, Angelika Lampert
Mutations in voltage-gated sodium channels are associated with altered pain perception in humans. Most of these mutations studied to date present with a direct and intuitive link between the altered electrophysiological function of the channel and the phenotype of the patient. In this study, we characterize a variant of Nav1.8, D1639N, which has been previously identified in a patient suffering from the chronic pain syndrome "small fiber neuropathy". Using a heterologous expression system and patch-clamp analysis, we show that Nav1...
August 11, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30066214/the-prescription-of-lidocaine-patches-in-osteoarthritis-a-complete-audit-cycle
#2
Rosie Mc Colgan, David M Dalton, Hugh P O'Sullivan, James A Sproule
OBJECTIVES: Nationally, 5% of the population have been prescribed topical lidocaine patches (TLPs). These patches cost €77-230 per month. The only licensed indication for TLP is post-herpetic neuralgia (PHN). It has not proven to be effective for any other indication including musculoskeletal and post-surgical pain. It is estimated that only 5-10% of patients on TLP have PHN. The aim of this study was to audit the number of inpatients currently prescribed TLP-appropriately and inappropriately-and to examine the prescribing patterns...
July 31, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29988901/transient-complete-visual-loss-and-subsequent-cystoid-macular-edema-after-intracameral-lidocaine-injection-following-uneventful-cataract-surgery
#3
Mehrdad Mohammadpour, Hamid Riazi-Esfahani
Purpose: To report a case of transient visual loss following uncomplicated cataract surgery with unpreserved intracameral lidocaine. Methods: A 61-year-old woman with nuclear sclerosis cataract underwent uncomplicated phacoemulsification and in-the-bag intraocular lens (IOL) implantation. Results: After opening the eye patch on the first postoperative day, the patient complained of complete blindness. Her vision was no light perception (NLP) and the Marcus-Gunn was found to be 4+...
June 2018: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/29913873/postherpetic-neuralgia-new-hopes-in-prevention-with-adult-vaccination-and-in-treatment-with-a-concentrated-capsaicin-patch
#4
Ewa Gawecka, Oddbjørn Viken
Background and purpose Postherpetic neuralgia (PHN) is a complication of acute herpes zoster (HZ). The evidence base for management of PHN has increased by recent publications. Therefore, we reviewed incidence of HZ, prevalence, risk factors, and mechanism of PHN pain, prevention and treatment of PHN with special interest in studies on adult vaccination and topical application of lidocaine and concentrated capsaicin patch. Methods We searched databases with an English language restriction: MEDLINE 1944-2011, EMBASE 1988-2011, PubMed, and the Cochrane Controlled Trial Register and Cochrane Library (2011)...
October 1, 2012: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29794759/comparison-of-the-effectiveness-in-pain-reduction-and-pulmonary-function-between-a-rib-splint-constructed-in-the-er-and-a-manufactured-rib-splint
#5
RANDOMIZED CONTROLLED TRIAL
Yoonje Lee, Sang-Hyun Lee, Changsun Kim, Hyuk Joong Choi
BACKGROUND: In the treatment of patients with rib fractures (RFs), pain reduction is the most important consideration. Various studies have examined the effectiveness of treatments administered to RF patients, such as lidocaine patches, IV drugs, nerve blockers, and surgery. In this study, we evaluated the difference in the effectiveness in pain reduction between 2 groups of RF patients: 1 group who received a rib splint constructed in the ER (ER splint) and another group who received a Chrisofix Chest Orthosis (CCO) manufactured rib splint...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29706996/does-the-use-of-nitroglycerin-patch-improve-local-anaesthetic-effects-in-bier-s-block-a-double-blind-placebo-controlled-study
#6
Ahmed Said Elgebaly
Aim: The aim of the study was to assess the nitroglycerin patch as a new additive to Bier's block and its impact on the effects and dose of lidocaine. Methods: Forty patients of each sex belonging to ASA I or II underwent elective tendon repair surgeries of the forearm and hand. The patients were divided into two equal groups as follows: Group C received only lidocaine (1.5 mg/kg, 0.25%) and Group N received lidocaine (1.5 mg/kg, 0.25%) + 5 mg transcutaneous nitroglycerin patch...
2018: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/29672324/lidocaine-patch-to-treat-postoperative-tourniquet-pain-after-total-knee-replacement-a-case-report
#7
Brittney M Clark, Gabriel L Pagani-Estevez, Rebecca L Johnson
Intraoperative tourniquet-related pain is well recognized by anesthesiologists, but postoperative tourniquet-related pain has received little attention. We present a patient who underwent a total knee arthroplasty under general anesthesia and an adductor canal nerve block. She complained of intractable thigh pain postoperatively. Lidocaine 5% patches completely resolved her postoperative tourniquet-related pain.
April 17, 2018: A&A practice
https://www.readbyqxmd.com/read/29562618/transdermal-and-topical-drug-administration-in-the-treatment-of-pain
#8
REVIEW
Wojciech Leppert, Malgorzata Malec-Milewska, Renata Zajaczkowska, Jerzy Wordliczek
The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients' age, comorbidities, and appropriate choice of analgesic, its dose and route of administration. This review is aimed at presenting current knowledge on analgesics administered by transdermal and topical routes for physicians, nurses, pharmacists, and other health care professionals dealing with patients suffering from pain. Analgesics administered transdermally or topically act through different mechanisms...
March 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29553987/chronic-postsurgical-pain-and-cancer-the-catch-of-surviving-the-unsurvivable
#9
Stephen R Humble, Nicolas Varela, Asantha Jayaweera, Arun Bhaskar
PURPOSE OF REVIEW: Chronic postsurgical pain (CPSP) is an important and well recognized cause of much long-term suffering, which in some cases may be preventable and affects many people living with cancer. Unfortunately, general consensus is lacking as to how best reduce the risk of developing CPSP. RECENT FINDINGS: Cancer is now not always a short-lived, fatal disease and is now moving towards a chronic illness. Poorly managed perioperative pain is the greatest risk factor for CPSP...
June 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29509584/sodium-channel-nav1-3-is-expressed-by-polymorphonuclear-neutrophils-during-mouse-heart-and-kidney-ischemia-in-vivo-and-regulates-adhesion-transmigration-and-chemotaxis-of-human-and-mouse-neutrophils-in-vitro
#10
Marit Poffers, Nathalie Bühne, Christine Herzog, Anja Thorenz, Rongjun Chen, Faikah Güler, Axel Hage, Andreas Leffler, Frank Echtermeyer
BACKGROUND: Voltage-gated sodium channels generate action potentials in excitable cells, but they have also been attributed noncanonical roles in nonexcitable cells. We hypothesize that voltage-gated sodium channels play a functional role during extravasation of neutrophils. METHODS: Expression of voltage-gated sodium channels was analyzed by polymerase chain reaction. Distribution of Nav1.3 was determined by immunofluorescence and flow cytometry in mouse models of ischemic heart and kidney injury...
June 2018: Anesthesiology
https://www.readbyqxmd.com/read/29415859/effects-of-transdermal-lidocaine-or-lidocaine-with-prilocaine-or-tetracaine-on-mechanical-superficial-sensation-and-nociceptive-thermal-thresholds-in-horses
#11
Franz J Söbbeler, Sabine Br Kästner
OBJECTIVE: To evaluate the transdermal local anaesthetic effect of lidocaine or lidocaine combined with prilocaine or tetracaine in horses. STUDY DESIGN: Experimental, randomized study. ANIMALS: A total of five healthy adult warmblood horses. METHODS: Horses were clipped bilaterally at the withers, cranial saddle area and caudal saddle area. Baseline measurements for mechanical superficial sensation via von Frey filaments and nociceptive thermal thresholds were performed...
March 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29251644/pharmacodynamics-and-pharmacokinetics-of-lidocaine-in-a-rodent-model-of-diabetic-neuropathy
#12
Werner Ten Hoope, Markus W Hollmann, Kora de Bruin, Hein J Verberne, Arie O Verkerk, Hanno L Tan, Camiel Verhamme, Janneke Horn, Marcel Rigaud, Susanne Picardi, Philipp Lirk
BACKGROUND: Clinical and experimental data show that peripheral nerve blocks last longer in the presence of diabetic neuropathy. This may occur because diabetic nerve fibers are more sensitive to local anesthetics or because the local anesthetic concentration decreases more slowly in the diabetic nerve. The aim of this study was to investigate both hypotheses in a rodent model of neuropathy secondary to type 2 diabetes. METHODS: We performed a series of sciatic nerve block experiments in 25 Zucker Diabetic Fatty rats aged 20 weeks with a neuropathy component confirmed by neurophysiology and control rats...
March 2018: Anesthesiology
https://www.readbyqxmd.com/read/29141003/trpa1-and-trpv1-are-required-for-lidocaine-evoked-calcium-influx-and-neuropeptide-release-but-not-cytotoxicity-in-mouse-sensory-neurons
#13
Mirjam Eberhardt, Thomas Stueber, Jeanne de la Roche, Christine Herzog, Andreas Leffler, Peter W Reeh, Katrin Kistner
BACKGROUND: Local anaesthetics (LA) reduce neuronal excitability by inhibiting voltage-gated Na+ channels. When applied at high concentrations in the direct vicinity of nerves, LAs can also induce relevant irritation and neurotoxicity via mechanisms involving an increase of intracellular Ca2+. In the present study we explored the role of the Ca2+-permeable ion channels TRPA1 and TRPV1 for lidocaine-induced Ca2+-influx, neuropeptide release and neurotoxicity in mouse sensory neurons. METHODS: Cultured dorsal root ganglion (DRG) neurons from wildtype and mutant mice lacking TRPV1, TRPA1 or both channels were explored by means of calcium imaging, whole-cell patch clamp recordings and trypan blue staining for cell death...
2017: PloS One
https://www.readbyqxmd.com/read/29135709/pilot-study-comparing-topical-anesthetic-agents-in-pterygium-surgery-subconjunctival-injection-versus-2-lidocaine-gel-versus-5-lidocaine-gel
#14
RANDOMIZED CONTROLLED TRIAL
Felipe Pereira, Hélio Francisco Shiroma, Muller Gonçalves Urias, Verônica Haysa Yamada, Acácio Alves de Souza Lima, Ana Luisa Hofling-Lima, Michel Eid Farah, Eduardo Buchele Rodrigues
PURPOSE: To compare the efficacy of different concentrations of topical lidocaine gel with standard subconjunctival anesthesia. METHODS: This was a prospective randomized controlled pilot study with 3 different groups. Group SC received subconjunctival lidocaine and proparacaine drops as needed during surgery. Group L2 received 2% lidocaine gel and group L5 received 5% lidocaine gel. Both lidocaine gel groups could receive another gel dose as needed during the procedure...
February 2018: Cornea
https://www.readbyqxmd.com/read/29128504/biophysical-comparison-of-sodium-currents-in-native-cardiac-myocytes-and-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#15
Robert J Goodrow, Suveer Desai, Jacqueline A Treat, Brian K Panama, Mayurika Desai, Vladislav V Nesterenko, Jonathan M Cordeiro
INTRODUCTION: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are used for safety pharmacology and to investigate genetic diseases affecting cardiac ion channels. It is unclear whether adult myocytes or hiPSC-CMs are the better platform for cardiac safety pharmacology. We examined the biophysical and molecular properties of INa in adult myocytes and hiPSC-CMs. METHODS: hiPSC-CMs were plated at low density. Atrial and ventricular cells were obtained from dog hearts...
March 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29125423/management-of-chronic-neuropathic-pain-with-single-and-compounded-topical-analgesics
#16
REVIEW
Nebojsa Nick Knezevic, Tatiana Tverdohleb, Farid Nikibin, Ivana Knezevic, Kenneth D Candido
The goal of our review was to emphasize important aspects that physicians should take into consideration when prescribing topical analgesics as part of chronic neuropathic pain treatment. We discuss the dermatopharmacokinetics and microstructural components of the skin, differences between topical and transdermal drug delivery, and topical medication effects on peripheral neuropathy and central sensitization. Even though the US FDA approved topical analgesics are 8%-capsaicin and 5%-lidocaine patches for treating postherpetic neuralgia, there are many other studies conducted on the efficacy of topical ketamine cream, clonidine gel, topical gabapentin, topical baclofen and topical phenytoin for peripheral neuropathic pain, either alone or in combination with other formulations...
November 2017: Pain Management
https://www.readbyqxmd.com/read/28884140/treatment-of-cutaneous-leiomyomas-with-5-lidocaine-patches-in-a-patient-with-hereditary-leiomyomatosis-and-renal-cell-cancer-reed-syndrome
#17
Tina Hsu, Lynn A Cornelius, Ilana S Rosman, Kathleen M Nemer
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28875384/rare-cause-of-delirium-and-hypoxemia-after-coronary-bypass-surgery-transdermal-lidocaine-patch-associated-methemoglobinemia
#18
Fidel A Acevedo, Esther J Kim, David A Chyatte, Vance G Nielsen
We present a case of a patient administered parasternal transdermal lidocaine patch therapy as part of a multimodal analgesic regime designed to diminish opioid-associated delirium after coronary bypass surgery. The patient presented with delirium and severe methemoglobinemia (41%) that responded to discontinuation of lidocaine therapy, oxygen administration, and methylene blue administration. The clinical contributors and medicolegal implications of this degree of lidocaine-associated methemoglobin-mediated delirium are presented in the hope of avoiding similar complications in the postoperative setting after coronary bypass surgery...
May 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28856112/the-efficacy-of-systemic-lidocaine-in-the-management-of-chronic-pain-a-literature-review
#19
REVIEW
Fardin Yousefshahi, Oana Predescu, Juan Francisco Asenjo
CONTEXT: Despite recent advances in the understanding of the chronic pain concept, its diagnosis and management remains a daily challenge for clinicians and patients. Based on the published literature, this review discusses and tries to organize the current knowledge and the up-to-date clinical experience about the efficacy and safety of the use of intravenous lidocaine in treatment and prevention of chronic pain. EVIDENCE ACQUISITION: To prepare this narrative review, we performed an in depth literature review using the PubMed searching engine...
June 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28805147/a-comparison-of-transdermal-over-the-counter-lidocaine-3-6-menthol-1-25-rx-lidocaine-5-and-placebo-for-back-pain-and-arthritis
#20
RANDOMIZED CONTROLLED TRIAL
Eric Castro, David Dent
AIM: Transdermal lidocaine therapy has become a gold standard as part of a treatment regimen for patients who suffer from localized pain. We compared transdermal patches: over-the-counter (OTC) lidocaine 3.6% combined with menthol 1.25%, prescription lidocaine 5% (Rx) and placebo. METHODS: In a double-blind, placebo-controlled trial, 87 patients were randomized to: OTC, Rx or placebo. RESULTS: OTC met primary end points of noninferiority compared with Rx for efficacy, side effects and quality of life...
November 2017: Pain Management
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