Wen-Sheng Liu, Shih-Shin Liang, Mei-Mei Cheng, Ming-Tsan Wu, Szu-Yuan Li, Tien-Tien Cheng, Tsung-Yun Liu, Ching-Yao Tsai, Yen-Ting Lai, Chien-Hung Lin, Hsiang-Tsui Wang, Han-Hsing Tsou
The number of patients with chronic kidney disease (CKD) is increasing. Oral toxin adsorbents may provide some value. Several uremic toxins, including indoxyl sulfate (IS), p-cresol (PCS), acrolein, per- and poly-fluoroalkyl substances (PFAS), and inflammation markers (interleukin 6 [IL-6] and tumor necrosis factor [TNF]-alpha) have been shown to be related to CKD progression. A total of 81 patients taking oral activated charcoal toxin adsorbents (AC-134), which were embedded in capsules that dissolved in the terminal ileum, three times a day for 1 month, were recruited...
April 4, 2024: Environmental Toxicology