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https://www.readbyqxmd.com/read/29035196/thyroid-function-in-patients-on-continuous-ambulatory-peritoneal-dialysis-in-comparison-with-chronic-kidney-disease%C3%A2
#1
Toru Sanai, Akinori Nagashima, Ken Okamura, Shuichi Rikitake, Makoto Fukuda, Koji Onozawa, Mai Sanematsu, Tsuyoshi Takashima, Motoaki Miyazono, Yuji Ikeda
BACKGROUND/METHODS: Thyroid function was evaluated in 14 Japanese patients on continuous ambulatory peritoneal dialysis (CAPD) with end-stage renal disease compared with 11 chronic kidney disease (CKD) stage 1+2 patients (glomerular filtration rate ≥ 60 mL/min/1.73m2). RESULTS: The serum free triiodothyronine (fT3) (2.2 ± 0.3 pg/mL, p < 0.05) levels were lower, and the rate of low triiodothyronine (T3) syndrome was higher (4 of 13 cases, 30.8%) in the CAPD patients than in the CKD stage 1+2 patients (1 of 10 cases, 10...
October 16, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29033600/efficacy-and-safety-of-subcutaneous-administration-of-lyophilized-powder-of-alfa-erythropoietin-to-maintain-hemoglobin-concentrations-among-hemodialysis-patients
#2
Bancha Satirapoj, Rattanawan Dispan, Ouppatham Supasyndh
BACKGROUND: Anemia associated with chronic kidney disease (CKD) often requires treatment with recombinant human erythropoietin (EPO). This study investigated the therapeutic equivalence between lyophilized powder and standard liquid EPO alfa by subcutaneous (SC) administration in hemoglobin maintenance among patients on hemodialysis. METHODS: This was a single-blinded, randomized, controlled, single-center, parallel-group study regarding the treatment of anemia among CKD patients on hemodialysis and being treated with stable doses of EPO alfa at least for 12 weeks...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29032954/coronary-flow-reserve-is-predictive-of-the-risk-of-cardiovascular-death-regardless-of-chronic-kidney-disease-stage
#3
David M Charytan, Hicham Skali, Nishant R Shah, Vikas Veeranna, Michael K Cheezum, Viviany R Taqueti, Takashi Kato, Courtney R Bibbo, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Marcelo F Di Carli
Microvascular rarefaction is found in experimental uremia, but data from patients with chronic kidney disease (CKD) are limited. We therefore quantified absolute myocardial blood flow and coronary flow reserve (the ratio of peak to resting flow) from myocardial perfusion positron emission tomography scans at a single institution. Individuals were classified into standard CKD categories based on the estimated glomerular filtration rate. Associations of coronary flow reserve with CKD stage and cardiovascular mortality were analyzed in models adjusted for cardiovascular risk factors...
October 13, 2017: Kidney International
https://www.readbyqxmd.com/read/29032376/impact-of-uric-acid-levels-on-kidney-disease-progression
#4
Hernan Rincon-Choles, Stacey E Jolly, Susana Arrigain, Victoria Konig, Jesse D Schold, Georges Nakhoul, Sankar D Navaneethan, Joseph V Nally, Michael B Rothberg
BACKGROUND: Hyperuricemia is associated with the progression of chronic kidney disease (CKD), but it is not known whether the relationship is causal. We examined the association of hyperuricemia and uric acid lowering therapy (UALT) with progression of CKD in patients with CKD 3 and 4 in the Cleveland Clinic CKD registry. METHODS: We included 1,676 patients with CKD stages 3 and 4 from Ohio, who had measured their uric acid (UA) levels a year prior to the recording of the second eGFR <60 mL/min/1...
October 13, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29031006/the-kidney-and-cvots
#5
EDITORIAL
Zachary Bloomgarden
Chronic kidney disease (CKD) affects a substantial minority of persons with type 2 diabetes. Analysis of US National Health and Nutrition Examination Survey (NHANES) datasets from 2007 through 2012 showed stage 3 or worse disease (estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m(2) ) in nearly one in five patients, with increasing age, blood pressure, obesity and levels of glycemia all associated with higher likelihood ((1) ), comparable to findings from surveys from many other areas, which also show micro- or macroalbuminuria to be present in one sixth to one third of diabetic persons ((2) )...
October 14, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29028125/ledipasvir-and-tenofovir-drug-interaction-in-hiv-hcv-co-infected-patients-impact-on-tenofovir-ctrough-and-renal-safety
#6
Caroline Solas, Sylvie Bregigeon, Olivia Faucher-Zaegel, Sylvie Quaranta, Véronique Obry-Roguet, Catherine Tamalet, Bruno Lacarelle, Isabelle Poizot-Martin
We evaluate the impact of ledipasvir on both tenofovir plasma trough concentration (Ctrough ) and estimated glomerular renal function (eGFR) in HIV-HCV co-infected patients receiving a tenofovir(TDF)-based antiretroviral regimen and treated with ledipasvir/sofosbuvir. Twenty-six patients [81% male, median age: 51years; HCV genotype 1(75%)/4(15%)] were included. Tenofovir Ctrough (interquartile:IQR) increased from 78ng/mL (53-110) at baseline to 141ng/mL (72-176) at M1 (p=0.003). No significant difference on eGFR using both Cockroft-Gault and MDRD formula, respectively [median(IQR)] was observed between baseline [101...
October 13, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29027620/evaluation-of-the-tolerability-and-efficacy-of-sodium-polystyrene-sulfonate-for-long-term-management-of-hyperkalemia-in-patients-with-chronic-kidney-disease
#7
Panagiotis I Georgianos, Ioannis Liampas, Andreas Kyriakou, Vasilios Vaios, Vasilios Raptis, Nikolaos Savvidis, Athanasios Sioulis, Vassilios Liakopoulos, Elias V Balaskas, Pantelis E Zebekakis
PURPOSE: Sodium polystyrene sulfonate (SPS) is a cation-exchanging resin that has been widely used for several decades as first-line therapy of mild chronic hyperkalemia in patients with chronic kidney disease (CKD). However, evidence to prove the long-term tolerability and efficacy of SPS for the treatment of this condition is still missing. METHODS: In this retrospective, observational study, we enrolled 26 outpatients with stages 3-4 CKD who received oral therapy with low-dose SPS for mild chronic hyperkalemia in the Outpatient Nephrology clinic of our Department during 2010-2016...
October 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29022223/acute-kidney-injury-in-pregnancy-and-the-role-of-underlying-ckd-a-point-of-view-from-m%C3%A3-xico
#8
REVIEW
Margarita Ibarra-Hernández, Oralia Alejandra Orozco-Guillén, María Luz de la Alcantar-Vallín, Ruben Garrido-Roldan, María Patricia Jiménez-Alvarado, Kenia Benitez Castro, Francisco Villa-Villagrana, Mario Borbolla, Juan Manuel Gallardo-Gaona, Guillermo García-García, Norberto Reyes-Paredes, Giorgina Barbara Piccoli
The incidence of acute kidney injury in pregnancy (P-AKI) in developed countries is significantly lower than in developing ones, where it is estimated to range between 4 and 26%. Mortality in cases of P-AKI requiring dialysis is high, varying from 20 to 80%. In developing countries, clinical decisions are often based on the availability of services and not on needs. Prenatal surveillance in Mexico does not include serum creatinine, limiting the potential for early diagnosis of AKI and CKD and their differential diagnosis...
October 11, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/29021477/management-of-osteoporosis-in-chronic-kidney-disease
#9
Kosaku Nitta, Aiji Yajima, Ken Tsuchiya
Chronic kidney disease (CKD) patients with coexisting osteoporosis are becoming common. Many of the therapeutic agents used to treat osteoporosis are known to be affected by the renal function. It is generally thought that osteoporosis in G1 to G3 CKD patients can be treated as in non-CKD patients with osteoporosis. In stage 4 or more advanced CKD patients and CKD patients on dialysis with osteoporosis, however, bisphosphonates must be used with caution, bearing in mind the potential development of such disorders as adynamic bone disease...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29021384/impaired-%C3%AE-oxidation-and-altered-complex-lipid-fatty-acid-partitioning-with-advancing-ckd
#10
Farsad Afshinnia, Thekkelnaycke M Rajendiran, Tanu Soni, Jaeman Byun, Stefanie Wernisch, Kelli M Sas, Jennifer Hawkins, Keith Bellovich, Debbie Gipson, George Michailidis, Subramaniam Pennathur
Studies of lipids in CKD, including ESRD, have been limited to measures of conventional lipid profiles. We aimed to systematically identify 17 different lipid classes and associate the abundance thereof with alterations in acylcarnitines, a metric of β-oxidation, across stages of CKD. From the Clinical Phenotyping Resource and Biobank Core (CPROBE) cohort of 1235 adults, we selected a panel of 214 participants: 36 with stage 1 or 2 CKD, 99 with stage 3 CKD, 61 with stage 4 CKD, and 18 with stage 5 CKD. Among participants, 110 were men (51...
October 11, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29018140/incident-ckd-after-radical-or-partial-nephrectomy
#11
John T Leppert, Remy W Lamberts, I-Chun Thomas, Benjamin I Chung, Geoffrey A Sonn, Eila C Skinner, Todd H Wagner, Glenn M Chertow, James D Brooks
The comparative effectiveness of partial nephrectomy versus radical nephrectomy to preserve kidney function has not been well established. We determined the risk of clinically significant (stage 4 and higher) CKD after radical or partial nephrectomy among veterans treated for kidney cancer in the Veterans Health Administration (2001-2013). Among patients with preoperative eGFR≥30 ml/min per 1.73 m(2), the incidence of CKD stage 4 or higher after radical (n=9759) or partial nephrectomy (n=4370) was 7.9% overall...
October 10, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28994640/serum-symmetric-dimethylarginine-and-creatinine-in-birman-cats-compared-with-cats-of-other-breeds
#12
Saverio Paltrinieri, Marco Giraldi, Amanda Prolo, Paola Scarpa, Eleonora Piseddu, Massimo Beccati, Benedetta Graziani, Stefano Bo
Objectives The aim of this study was to assess whether, in contrast to serum creatinine, which is higher in Birman cats than in other breeds, the serum concentration of symmetric dimethylarginine (SDMA) is comparable in clinically healthy Birmans and in the general feline population. This could allow, in this breed, to better evaluate chronic kidney disease (CKD). Methods Serum creatinine and SDMA were measured in clinically healthy Birmans (n = 50) and in cats of other breeds (n = 46), and the results were statistically compared...
October 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28992139/concentrations-of-representative-uraemic-toxins-in-a-healthy-versus-non-dialysis-chronic-kidney-disease-paediatric-population
#13
Evelien Snauwaert, Wim Van Biesen, Ann Raes, Griet Glorieux, Valerie Van Bogaert, Koen Van Hoeck, Marc Coppens, Sanne Roels, Johan Vande Walle, Sunny Eloot
Background: Chronic kidney disease (CKD) in childhood is poorly explained by routine markers (e.g. urea and creatinine) and is better depicted in adults by other uraemic toxins. This study describes concentrations of representative uraemic toxins in non-dialysis CKD versus healthy children. Methods: In 50 healthy children and 57 children with CKD Stages 1-5 [median estimated glomerular filtration rate 48 (25th-75th percentile 24-71) mL/min/1.73 m 2 ; none on dialysis], serum concentrations of small solutes [symmetric and asymmetric dimethyl-arginine (SDMA and ADMA, respectively)], middle molecules [β2-microglobuline (β2M), complement factor D (CfD)] and protein-bound solutes [ p -cresylglucuronide (pCG), hippuric acid (HA), indole-acetic acid (IAA), indoxyl sulphate (IxS), p -cresyl sulphate (pCS) and 3-carboxy-4-methyl-5-propyl-furanpropionic acid (CMPF)] were measured...
July 24, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28987723/low-dose-aspirin-increases-15-epi-lipoxin-a4-levels-in-diabetic-chronic-kidney-disease-patients
#14
Marian Goicoechea, Maria Dolores Sanchez-Niño, Alberto Ortiz, Soledad García de Vinuesa, Borja Quiroga, Carmen Bernis, Enrique Morales, Gema Fernández-Juarez, Patricia de Sequera, Ursula Verdalles, Eduardo Verde, José Luño
BACKGROUND: Resolution of inflammation is regulated by endogenous lipid mediators, such as lipoxins and their epimers, including 15-epi-lipoxin A4 (15-epi-LXA4). However, there is no information on 15-epi-LXA4 and its in vivo regulation in chronic kidney disease (CKD) patients. STUDY DESIGN: Open label randomized clinical trial. SETTING AND PARTICIPANTS: 50 participants with chronic kidney disease (CKD) stage 3 and 4 without prior cardiovascular disease (25 in the aspirin group and 25 in the standard group) followed for 46 months...
October 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28982638/prospective-cohort-analyzing-risk-factors-for-chronic-kidney-disease-progression-in-children
#15
Vera M S Belangero, Liliane C Prates, Andreia Watanabe, Benita S G Schvartsman, Paula Nussenzveig, Natalia A Cruz, Ana L S Abreu, Isabel P Paz, Inalda Facincani, Fernanda E C Morgantetti, Andreia O Silva, Olberes V B Andrade, Maria F C Camargo, Paulo C Koch Nogueira
OBJECTIVE: To identify risk factors for chronic kidney disease (CKD) progression in Brazilian children and to evaluate the interactions between factors. METHODS: This was a multicenter prospective cohort in São Paulo, involving 209 children with CKD stages 3-4. The study outcome included: (a) death, (b) start of kidney replacement therapy, (c) eGFR decrease >50% during the followup. Thirteen risk factors were tested using univariate regression models, followed by multivariable Cox regression models...
October 2, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28979782/elderly-patients-with-chronic-kidney-disease-do-they-really-need-referral-to-the-nephrology-clinic
#16
Mark McClure, Thomas Jorna, Laura Wilkinson, Joanne Taylor
INTRODUCTION: Chronic kidney disease (CKD) is becoming increasingly common, especially in the elderly. In the UK, there has been a marked increase in the awareness and detection of CKD over the last decade. This is largely attributable to the introduction of automated estimated glomerular filtration rate (eGFR) reporting and renal indicators in the primary care Quality and Outcomes Framework (QOF) initiative, both of which were introduced in 2006. These two initiatives have had a significant impact on referral patterns to renal services...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28979779/a-clinical-genetic-approach-to-assessing-cardiovascular-risk-in-patients-with-ckd
#17
Emilio Rodrigo, Sara Pich, Isaac Subirana, Gema Fernandez-Fresnedo, Paloma Barreda, Carles Ferrer-Costa, Ángel Luis M de Francisco, Eduardo Salas, Roberto Elosua, Manuel Arias
BACKGROUND: Coronary heart disease (CHD) is the primary cause of death in individuals with chronic kidney disease (CKD), but current equations for assessing coronary risk have low accuracy in this group. We have reported that the addition of a genetic risk score (GRS) to the Framingham risk function improved its predictive capacity in the general population. The aims of this study were to evaluate the association between this GRS and coronary events in the CKD population and to determine whether the addition of the GRS to coronary risk prediction functions improves the estimation of coronary risk at the earliest possible stages of kidney disease...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28978205/all-cause-costs-increase-exponentially-with-increased-chronic-kidney-disease-stage
#18
Ladan Golestaneh, Paula J Alvarez, Nancy L Reaven, Susan E Funk, Karen J McGaughey, Alain Romero, Melanie S Brenner, Macaulay Onuigbo
OBJECTIVE: To evaluate the economic impact of chronic kidney disease (CKD) on US health plans. STUDY DESIGN: A retrospective analysis identified patients with a renin-angiotensin-aldosterone system inhibitor (RAASi) prescription from an electronic medical record (EMR) database (Humedica); those with =90 days in =1 CKD stage were selected based on estimated glomerular filtration rate or diagnosis code, and a cohort on RAASi medications without CKD was selected. Costs for specific services obtained from OptumInsight were applied to services in EMR data of patients aged <65 years (commercial) and =65 years (Medicare)...
June 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28976989/vitamin-d-and-methylarginines-in-chronic-kidney-disease-ckd
#19
Claudia Torino, Patrizia Pizzini, Sebastiano Cutrupi, Rocco Tripepi, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali
BACKGROUND: Vitamin D associates with the plasma concentration of the endogenous inhibitor of the nitric oxide system asymmetric dimethyl arginine (ADMA) and cross-sectional studies in CKD patients treated with the vitamin D receptor activator paricalcitol show that plasma ADMA is substantially less than in those not receiving this drug. METHODS: In the frame of a randomized, double-blind, placebo controlled trial, the Paracalcitol and ENdothelial fuNction in chronic kidneY disease (PENNY), we investigated whether vitamin D receptor activation by paricalcitol (2 μg/day x 12 weeks) affects the plasma concentration of ADMA and symmetric dimethyl arginine (SDMA) in 88 patients with stage 3 to 4 CKD...
2017: PloS One
https://www.readbyqxmd.com/read/28971154/value-of-plasma-neutrophil-gelatinase-associated-lipocalin-ngal-in-distinguishing-between-acute-kidney-injury-aki-and-chronic-kidney-disease-ckd
#20
Seref Kerem Corbacıoglu, Yunsur Cevik, Emine Akinci, Hüseyin Uzunosmanoglu, Seda Dagar, Tuba Safak, Veysel Oncul, Murat Guvendi
OBJECTIVE: In this study, we aimed to determine whether plasma NGAL levels could be used as a biomarker for distinguishing between AKI and CKD in emergency medicine. MATERIALS AND METHODS: This prospective study was conducted at the ED of a training and research hospital over a six-month period in 2015. Three groups were defined: an AKI group - defined as a new onset of at least a 1.5-fold or ≥0.3 mg increment increase of SCr values from the normal baseline, a stable CKD group - only included presence of stages 2 through 4 of CKD according to the National Kidney Foundation's KDIGO 2012, and a control group...
September 2017: Turkish Journal of Emergency Medicine
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