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https://www.readbyqxmd.com/read/30267783/dysregulation-of-mucosal-membrane-transporters-and-drug-metabolizing-enzymes-in-ulcerative-colitis
#1
Pascal Erdmann, Henrike Bruckmueller, Paul Martin, Diana Busch, Sierk Haenisch, Janett Müller, Anna Wiechowska-Kozlowska, Lars Ivo Partecke, Claus-Dieter Heidecke, Ingolf Cascorbi, Marek Drozdzik, Stefan Oswald
Intestinal transporters and metabolizing enzymes are important factors of the intestinal absorption barrier. Because there is evidence that their expression and function may be affected during inflammatory conditions, we investigated gene expression, protein abundance and regulation of relevant intestinal transporters and metabolizing enzymes in the intestinal mucosa of ulcerative colitis (UC) patients. Specimens from inflamed and non-inflamed tissues of 10 UC patients as well as colonic control tissues of 10 patients without inflammation were subjected to gene (9 enzymes, 15 transporters, 9 cytokines) and microRNA (N=54) expression analysis...
September 26, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30181510/cariprazine-a-dopamine-d%C3%A2-d%C3%A2-receptor-partial-agonist-modulates-abcg2-mediated-multidrug-resistance-in-cancer
#2
Noor Hussein, Charles R Ashby, Haneen Amawi, Angelique Nyinawabera, Atul Vij, Vishwa M Khare, Chandrabose Karthikeyan, Amit K Tiwari
Multidrug resistance (MDR) is a continuing clinical problem that limits the efficacy of chemotherapy in cancer. The over expression of the ATP-binding cassette (ABC) family G2 (ABCG2) transporter is one of the main mechanisms that mediates MDR in cancer. Molecular modeling data indicated that cariprazine, a dopamine D₂/D₃ receptor partial agonist, had a significant binding affinity for ABCG2 transporter with a Glide XP score of -6.515. Therefore, in this in vitro study, we determined the effect of cariprazine on MDR resulting from the overexpression of ABCG2 transporters...
September 4, 2018: Cancers
https://www.readbyqxmd.com/read/29845279/salvianolic-acid-b-reverses-multidrug-resistance-in-nude-mice-bearing-human-colon-cancer-stem-cells
#3
Piaoting Guo, Jianchao Wang, Wencang Gao, Xia Liu, Shaofei Wu, Boshun Wan, Lei Xu, Yanhua Li
Salvianolic acid B (SalB) is a water‑soluble phenolic compound, extractable from Salvia miltiorrhiza, and has previously been demonstrated to reverse tumor multidrug resistance (MDR) in colon cancer cells. Cancer stem cells (CSCs) are closely associated with drug resistance. Therefore, establishing a nude mouse model bearing human colon CSCs is important for the study of the mechanisms underlying colon cancer drug resistance as well as the reversal of drug resistance. The present study aimed to establish a nude mouse model bearing human colon CSCs and to investigate the effects of SalB on the drug resistance exhibited by the nude mouse model as well as determine its underlying mechanism...
August 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29739115/upregulation-of-breast-cancer-resistance-protein-expression-was-decreased-in-plasma-membrane-of-colon-cancer-with-metastasis-of-lymphatic-node
#4
Ao Wu, Jiaoli Zhang, Liyan Zeng, Feng Li, Zhaoguang Dong, Yanling Feng, Xiaofang Jia, Jun-O Jin, Lijun Zhang
BACKGROUND: ATP-binding cassette sub-family G member 2 (ABCG2), an ABC transport protein involved in the efflux of anticancer compounds, has been reported to have altered expression levels in several cancers including breast, colon, and gastric cancer, etc. However, its expression change (up- or down-regulated in cancer) is still contradictory. METHODS: We performed immunohistochemistry to examine ABCG2 expression in the microarray with 90 pairs of colon cancer and their adjacent normal tissues...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29693155/assessing-stemness-and-proliferation-properties-of-the-newly-established-colon-cancer-stem-cell-line-csc480-and-novel-approaches-to-identify-dormant-cancer-cells
#5
Faisal Alowaidi, Saeed Mujahid Hashimi, Naif Alqurashi, Reem Alhulais, Saso Ivanovski, Bernadette Bellette, Adrian Meedenyia, Alfred Lam, Stephen Wood
To date two questions that remain unanswered regarding cancer are the following: i) how is it initiated, and ii) what is the role that cancer stem cells (CSCs) play in the disease process? Understanding the biology of CSCs and how they are generated is pivotal for the development of successful treatment regimens. To date, the lack of a representative cell model has prevented the successful identification and eradication of CSCs in vivo. The current methods of CSC identification are dependent on the protocol used to generate these cells, which has introduced variation and made the identification process more complicated...
June 2018: Oncology Reports
https://www.readbyqxmd.com/read/29247488/oxaliplatin-resistance-in-colorectal-cancer-cells-is-mediated-via-activation-of-abcg2-to-alleviate-er-stress-induced-apoptosis
#6
Hsi-Hsien Hsu, Ming-Cheng Chen, Rathinasamy Baskaran, Yueh-Min Lin, Cecilia H Day, Yi-Jiun Lin, Chuan-Chou Tu, Viswanadha Vijaya Padma, Wei-Wen Kuo, Chih-Yang Huang
Oxaliplatin (OXA), is a third generation platinum drug used as first-line chemotherapy in colorectal cancer (CRC). Cancer cells acquires resistance to anti-cancer drug and develops resistance. ATP-binding cassette (ABC) drug transporter ABCG2, one of multidrug resistance (MDR) protein which can effectively discharge a wide spectrum of chemotherapeutic agents out of cancer cells and subsequently reduce the intracellular concentration of these drugs. Role of ABCG2 and plausible molecular signaling pathways involved in Oxaliplatin-Resistant (OXA-R) colon cancer cells was evaluated in the present study...
July 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29219179/multidrug-resistant-lncrna-profile-in-chemotherapeutic-sensitive-and-resistant-ovarian-cancer-cells
#7
Juan Xu, Jiacong Wu, Chenyang Fu, Fang Teng, Siyu Liu, Chencheng Dai, Rong Shen, Xuemei Jia
Most ovarian cancer patients are chemosensitive initially, but finally relapse with acquired chemoresistance. Multidrug-resistance is the extremely terrible situation. The mechanism for the acquired chemoresistance of ovarian cancer patients is still not clear. LncRNAs have been recognized as the important regulator of a variety of biological processes, including the multidrug-resistant process. Here, we carried out the lncRNA sequencing of the ovarian cancer cell line A2780 and the paxitaxel resistant cell line A2780/PTX which is also cross resistant to the cisplatin and epirubicin...
June 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29020498/lncrna-ccat1-mir-130a-3p-axis-increases-cisplatin-resistance-in-non-small-cell-lung-cancer-cell-line-by-targeting-sox4
#8
Baoli Hu, Haifeng Zhang, Zuopei Wang, Feng Zhang, Haitao Wei, Li Li
BACKGROUND: Colon cancer-associated transcript-1 (CCAT1) has been demonstrated to act as an oncogene and promote chemoresistance in several cancers. However, little is known about the underlying mechanism of CCAT1 in cisplatin (DDP) resistance of non-small-cell lung cancer (NSCLC) cells. METHODS: qRT-PCR was performed to detect the expression levels of CCAT, miR-130a-3p, or sex-determining region Y-box 4 (SOX4) mRNA. Luciferase reporter assay, RNA immunoprecipitation (RIP), and qRT-PCR analysis were carried out to explore the potential targets of CCAT1 or miR-130a-3p...
December 2, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28600556/aldose-reductase-inhibitor-increases-doxorubicin-sensitivity-of-colon-cancer-cells-and-decreases-cardiotoxicity
#9
Himangshu Sonowal, Pabitra B Pal, Jian-Jun Wen, Sanjay Awasthi, Kota V Ramana, Satish K Srivastava
Anthracycline drugs such as doxorubicin (DOX) and daunorubicin remain some of the most active wide-spectrum and cost-effective drugs in cancer therapy. However, colorectal cancer (CRC) cells are inherently resistant to anthracyclines which at higher doses cause cardiotoxicity. Our recent studies indicate that aldose reductase (AR) inhibitors such as fidarestat inhibit CRC growth in vitro and in vivo. Here, we show that treatment of CRC cells with fidarestat increases the efficacy of DOX-induced death in HT-29 and SW480 cells and in nude mice xenografts...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28397046/targeting-bcrp-abcg2-by-rna-interference-enhances-the-chemotherapy-sensitivity-of-human-colon-cancer-side-population-cells
#10
Jun Hu, Jian Li, Xin Yue, Jia-Cang Wang, Jun-Feng Wang, Jian-Zhong Liu, Da-Lu Kong
Relapse and metastasis are frequent in colon cancer and may be linked to stem cell characteristics. This study isolated side population (SP) cells from a colon cancer cell line (Colo-320) and examined their self-renewal and differentiation abilities. Compared to non-SP (NSP) cells, SP colon cancer cells were more tumorigenic in vivo and exhibited more invasive characteristics and a greater ability to form colonies. Additionally, more cells were in G0/G1 phase and more highly expressed the multidrug resistance protein BCRP/ABCG2...
April 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28323029/the-dopamine-d-3-receptor-antagonists-pg01037-ngb2904-sb277011a-and-u99194-reverse-abcg2-transporter-mediated-drug-resistance-in-cancer-cell-lines
#11
Noor Hussein, Haneen Amawi, Chandrabose Karthikeyan, F Scott Hall, Roopali Mittal, Piyush Trivedi, Charles R Ashby, Amit K Tiwari
The ATP - binding cassette (ABC) family G2 (ABCG2) transporters are known to produce multidrug resistance (MDR) in cancer, thereby limiting the clinical response to chemotherapy. Molecular modeling data indicated that certain dopamine (DA) D3 receptor antagonists had a significant binding affinity for ABCG2 transporter. Therefore, in this in vitro study, we determined the effect of the D3 receptor antagonists PG01037, NGB2904, SB277011A, and U99194 on MDR resulting from the overexpression of ABCG2 transporters...
June 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28229027/risk-analysis-of-colorectal-cancer-incidence-by-gene-expression-analysis
#12
Wei-Chuan Shangkuan, Hung-Che Lin, Yu-Tien Chang, Chen-En Jian, Hueng-Chuen Fan, Kang-Hua Chen, Ya-Fang Liu, Huan-Ming Hsu, Hsiu-Ling Chou, Chung-Tay Yao, Chi-Ming Chu, Sui-Lung Su, Chi-Wen Chang
BACKGROUND: Colorectal cancer (CRC) is one of the leading cancers worldwide. Several studies have performed microarray data analyses for cancer classification and prognostic analyses. Microarray assays also enable the identification of gene signatures for molecular characterization and treatment prediction. OBJECTIVE: Microarray gene expression data from the online Gene Expression Omnibus (GEO) database were used to to distinguish colorectal cancer from normal colon tissue samples...
2017: PeerJ
https://www.readbyqxmd.com/read/28220297/what-roles-do-colon-stem-cells-and-gap-junctions-play-in-the-left-and-right-location-of-origin-of-colorectal-cancers
#13
James E Trosko, Heinz-Josef Lenz
This "Commentary" examines an important clinical observation that right-sided colorectal cancers appear less treatable than the left-sided cancers. The concepts of (a) the "initiation/promotion/progression" process, (b) the stem cell hypothesis, (c) the role gap junctional intercellular communication, (d) cancer cells lacking GJIC either because of the non-expression of connexin genes or of non-functional gap junction proteins, and (e) the role of the microbiome in promoting initiated colon stem cells to divide symmetrically or asymmetrically are examined to find an explanation...
March 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28212529/expression-of-the-cancer-stem-cell-markers-abcg2-and-oct-4-in-right-sided-colon-cancer-predicts-recurrence-and-poor-outcomes
#14
Jun Hu, Jian Li, Xin Yue, Jiacang Wang, Jianzhong Liu, Lin Sun, Dalu Kong
Right-sided colon cancer (RCC) has a poorer prognosis and a higher relapse rate than left-sided colon cancer (LCC). Like cancer stem cells (CSCs), RCC cells cannot be fully eradicated and are often involved in relapse or metastasis. Because CSCs may be linked with poor outcomes, CSC markers may have prognostic value in RCC. ATP-binding cassette sub-family G member 2 (ABCG2) and OCT-4 (also known as POU5F1) are among the most useful markers for CSC identification. We therefore examined the malignant behavior of ABCG2 and OCT-4 in vitro and in vivo, and their expression was assessed in pathology tissues obtained from clinicopathologically recurrent and non-recurrent cases...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/27906625/uric-acid-metabolism-of-kidney-and-intestine-in-a-rat-model-of-chronic-kidney-disease
#15
Michito Nagura, Yoshifuru Tamura, Takanori Kumagai, Makoto Hosoyamada, Shunya Uchida
Uric acid (UA) is a potential risk factor of the progression of chronic kidney disease (CKD). Recently, we reported that intestinal UA excretion might be enhanced via upregulation of the ATP-binding cassette transporter G2 (Abcg2) in a 5/6 nephrectomy (Nx) rat model. In the present study, we examined the mRNA and protein expressions of UA transporters, URAT1, GLUT9/URATv1, ABCG2 and NPT4 in the kidney and ileum in the same rat model. Additionally, we investigated the Abcg2 mRNA expression of ileum in hyperuricemic rat model by orally administering oxonic acid...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27838457/drug-selected-cell-line-panels-for-evaluation-of-the-pharmacokinetic-consequences-of-multidrug-resistance-proteins
#16
Andrzej Błauż, Błażej Rychlik
Through the selection with five chemotherapeutics of diverse chemical structures and modes of action (cis-diamminedichloroplatinum, doxorubicin, etoposide, methotrexate and vincristine), four multidrug-resistant cell line panels were developed. Cancer cell lines of different species (human and murine) as well as tissue/organ (skin, colon) origin, characterized by low endogenous expression of multidrug resistance (MDR) proteins and high sensitivity to anticancer agents, were used as parental cell lines. A selection process resulted in the upregulation of several ABC transporters (ABCB1/Abcb1a, ABCC1/Abcc1 and ABCG2/Abcg2), which was confirmed by a number of molecular and cell biology methods...
March 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27748801/acquisition-of-anticancer-drug-resistance-is-partially-associated-with-cancer-stemness-in-human-colon-cancer-cells
#17
Flaria El Khoury, Laurent Corcos, Stéphanie Durand, Brigitte Simon, Catherine Le Jossic-Corcos
Colorectal cancer (CRC) is one of the most aggressive cancers worldwide. Several anticancer agents are available to treat CRC, but eventually cancer relapse occurs. One major cause of chemotherapy failure is the emergence of drug-resistant tumor cells, suspected to originate from the stem cell compartment. The aim of this study was to ask whether drug resistance was associated with the acquisition of stem cell-like properties. We isolated drug-resistant derivatives of two human CRC cell lines, HT29 and HCT116, using two anticancer drugs with distinct modes of action, oxaliplatin and docetaxel...
December 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27709738/wnt-%C3%AE-catenin-signaling-regulates-abcc3-mrp3-transporter-expression-in-colorectal-cancer
#18
Minoru Kobayashi, Ryo Funayama, Shinobu Ohnuma, Michiaki Unno, Keiko Nakayama
We determined the gene expression profiles for 48 ATP binding cassette (ABC) transporters in matched colon cancer and normal colon tissues in order to provide insight into the mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCB1, ABCC1, ABCC2, ABCC3, and ABCG2 was altered in association with colon carcinogenesis. Among these transporters, the expression of ABCC3 was repressed by Wnt signaling pathway in colon cancer cell lines. Knockdown of the pathway components transcription factor 7-like 2 (TCF7L2) or β-catenin thus increased ABCC3 expression, whereas activation of Wnt signaling with inhibitors of glycogen synthase kinase-3β (GSK-3β) reduced it...
December 2016: Cancer Science
https://www.readbyqxmd.com/read/27449042/abcg2-is-required-for-self-renewal-and-chemoresistance-of-cd133-positive-human-colorectal-cancer-cells
#19
Lijun Ma, Ting Liu, Yiran Jin, Jun Wei, Yinxue Yang, Hongquan Zhang
There is increasing evidence supporting the cancer stem cell (CSC) hypothesis, which suggests that a population of tumor cells with stem cell characteristics is responsible for tumor growth, resistance, and recurrence as well as drug resistance. In colorectal cancer, the CD133 antigen defines distinct cell subpopulations that are rich in tumor-initiating cells; however, the drug resistance properties of these CD133-positive cells have not been well defined. The breast cancer resistance protein (BCRP)/ATP-binding cassette subfamily G member 2 (ABCG2) is present on the plasma membrane of many types of human cancer cells and contributes to multidrug resistance during chemotherapy...
September 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27389299/photodynamic-therapy-with-5-aminolaevulinic-acid-and-dna-damage-unravelling-roles-of-p53-and-abcg2
#20
I Postiglione, F Barra, S M Aloj, G Palumbo
OBJECTIVES: In spite of high sensitivity of A549 cells (p53(+/+) ) to lethal effects of photodynamic therapy with 5-aminolaevulinic acid (5-ALA/PDT), DNA damage was observed only in H1299 cells (p53(-/-) ), suggesting that p53 may exert a protective effect. Studies on human colon adenocarcinoma cell lines HCT-116, and their cognate knockouts for p53, were not entirely consistent with the assumption above. Exploring alternative explanations for such conflicting behaviour, we observed that expression of the ATP-binding cassette G2 (ABCG2), a regulator of cell component efflux, had important effects on PDT-generated DNA injury in PC3 cells (prostate) which are p53(-/-) and positive for ABCG2...
August 2016: Cell Proliferation
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