keyword
https://read.qxmd.com/read/38439105/the-genetic-basis-of-hydrocephalus-genes-pathways-mechanisms-and-global-impact
#21
REVIEW
Andrew T Hale, Hunter Boudreau, Rishi Devulapalli, Phan Q Duy, Travis J Atchley, Michael C Dewan, Mubeen Goolam, Graham Fieggen, Heather L Spader, Anastasia A Smith, Jeffrey P Blount, James M Johnston, Brandon G Rocque, Curtis J Rozzelle, Zechen Chong, Jennifer M Strahle, Steven J Schiff, Kristopher T Kahle
Hydrocephalus (HC) is a heterogenous disease characterized by alterations in cerebrospinal fluid (CSF) dynamics that may cause increased intracranial pressure. HC is a component of a wide array of genetic syndromes as well as a secondary consequence of brain injury (intraventricular hemorrhage (IVH), infection, etc.) that can present across the age spectrum, highlighting the phenotypic heterogeneity of the disease. Surgical treatments include ventricular shunting and endoscopic third ventriculostomy with or without choroid plexus cauterization, both of which are prone to failure, and no effective pharmacologic treatments for HC have been developed...
March 4, 2024: Fluids and Barriers of the CNS
https://read.qxmd.com/read/38438818/symptoms-and-signs-did-not-predict-outcome-after-surgery-a-prospective-study-of-143-patients-with-idiopathic-normal-pressure-hydrocephalus
#22
JOURNAL ARTICLE
Kerstin Andrén, Carsten Wikkelsø, Katarina Laurell, Lena Kollén, Per Hellström, Mats Tullberg
OBJECTIVE: To determine the utility of symptoms, signs, comorbidities and background variables for the prediction of outcome of treatment in iNPH. METHODS: A prospective observational study of consecutively included iNPH patients, who underwent neurological, physiotherapeutic and neuropsychological assessments before and after shunt surgery. The primary outcome measure was the total change on the iNPH scale, and patients were defined as improved postoperatively if they had improved by at least five points on that scale...
March 5, 2024: Journal of Neurology
https://read.qxmd.com/read/38437685/postnatal-myelomeningocele-closure-in-smallest-reported-neonate-illustrative-case
#23
JOURNAL ARTICLE
Momin M Mohis, Kevin Cordeiro, Sarah Larson, Catharine Garland, James A Stadler
BACKGROUND: Myelomeningocele (MMC) is the most serious form of spina bifida, a congenital defect in neural tube development. Defect closure in a patient with an extremely low birth weight presents unique challenges and risks; lower birth weight is associated with multiple organ system concerns, homeostasis is difficult, and local tissue is underdeveloped. To the authors' knowledge, the present case is the lowest reported weight (490 g) for a neonate with postnatal MMC repair. OBSERVATIONS: A preterm male with a prenatally diagnosed lumbosacral MMC and associated Chiari malformation type II was born at 23 weeks 1 day to a 29-year-old mother, gravidity 6 parity 4...
March 4, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38437677/management-of-shunt-dysfunction-using-noninvasive-intracranial-pressure-waveform-monitoring-illustrative-case
#24
JOURNAL ARTICLE
Raphael Bertani, Caio Perret, Stefan Koester, Paulo Santa Maria, Savio Batista, Sophia de Andrade Cavicchioli, Sany Tomomi de Almeida Rocha Arita, Ruy Monteiro, Gianne Lucchesi, Fernando Augusto Vasconcellos, Matheus Miranda, Wellingson Silva Paiva, Fernando Gomes Pinto
BACKGROUND: Normal pressure hydrocephalus (NPH) treatment consists of using valves for drainage, as it is for hydrocephalus in general. Despite this, complications can occur, putting the patient at risk, and neurological monitoring is crucial. OBSERVATIONS: A 61-year-old male, who had been diagnosed with NPH 3 years prior and was being treated with a ventriculoperitoneal shunt with a programmable valve, presented to the emergency department because of a traumatic brain injury due to a fall from standing height...
March 4, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38437676/bifocal-germ-cell-tumor-of-pineal-germinoma-and-neurohypophyseal-embryonal-carcinoma-illustrative-case
#25
JOURNAL ARTICLE
Yu Naruse, Shinya Jinguji, Ryo Hiruta, Ayako Toda, Kenichiro Nagai, Shingo Kudo, Hideki Sano, Rei Sekine, Osamu Suzuki, Mudathir Bakhit, Masazumi Fujii
BACKGROUND: Bifocal germ cell tumors, with primarily identical tissue composition, occur concurrently in the neurohypophyseal and pineal regions. OBSERVATIONS: A 16-year-old male patient exhibited increased intracranial pressure symptoms, with concurrent tumors in the pineal and neurohypophyseal regions, causing obstructive hydrocephalus. His serum human chorionic gonadotropin level was elevated, measuring 506.6 mIU/mL. Upon gross endoscopic examination, the pineal tumor appeared white, whereas the neurohypophyseal tumor appeared red and hemorrhagic...
March 4, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38436063/design-of-a-stem-cell-based-therapy-for-ependymal-repair-in-hydrocephalus-associated-with-germinal-matrix-hemorrhages
#26
JOURNAL ARTICLE
Luis M Rodriguez-Perez, Betsaida Ojeda-Pérez, Javier López-de-San-Sebastián, María García-Bonilla, Marcos González-García, Beatriz Fernández-Muñoz, Rosario Sánchez-Pernaute, María L García-Martín, Dolores Domínguez-Pinos, Casimiro Cárdenas-García, Antonio J Jiménez, Patricia Paez-Gonzalez
BACKGROUND: In preterm birth germinal matrix hemorrhages (GMHs) and the consequent posthemorrhagic hydrocephalus (PHH), the neuroepithelium/ependyma development is disrupted. This work is aimed to explore the possibilities of ependymal repair in GMH/PHH using a combination of neural stem cells, ependymal progenitors (EpPs), and mesenchymal stem cells. METHODS: GMH/PHH was induced in 4-day-old mice using collagenase, blood, or blood serum injections. PHH severity was characterized 2 weeks later using magnetic resonance, immunofluorescence, and protein expression quantification with mass spectrometry...
March 4, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38435909/neoadjuvant-chemotherapy-approach-to-pineal-germinoma-a-case-report
#27
Nagham Bazzi, Wajih A Saad, Hala Bazzi, Mohammad Ali Almokdad, Abdo Mghames
Intracranial germ cell tumors (GCTs) are rare malignant tumors with a peak incidence around puberty. The pineal region is the most commonly involved area of all intracranial GCTs. Due to the heterogeneous tumor origin, subtypes, and presentation, diagnosis and management are challenging. Complicated pineal germinomas are rarely reported in the literature. Here, we report a rare case of pineal germinoma with hydrocephalus and discuss the potential treatment approach. A 20-year-old boy presented to the hospital with vomiting and a decreased level of consciousness...
January 2024: Curēus
https://read.qxmd.com/read/38429624/long-noncoding-rna-gas5-involved-progression-of-neonatal-hydrocephalus-and-inflammatory-responses
#28
JOURNAL ARTICLE
Bin Zou, Qin Zhang, Hui Gan, Yue Qin, Yudong Zhou, Xuan Zhai, Ping Liang
Intraventricular hemorrhage results in posthemorrhagic hydrocephalus (PHH). Neonatal hydrocephalus remains a challenging disease due to the high failure rate of all management strategies. We evaluated long noncoding RNA growth arrest-specific 5 (GAS5)-mediated network in neonatal hydrocephalus, providing a new direction for the treatment of hydrocephalus. The PHH model was constructed in neonatal rats after intracerebroventricular injection with GAS5, miR-325-3p, and chaperonin containing T-complex protein 1, subunit 8 (CCT8) plasmids, or oligonucleotides...
March 1, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38427140/endovascular-coiling-versus-neurosurgical-clipping-in-the-management-of-aneurysmal-subarachnoid-haemorrhage-in-the-elderly-a-multicenter-cohort-study
#29
MULTICENTER STUDY
Keng Siang Lee, Isabel Siow, Lily Wy Yang, Aaron Sc Foo, John Jy Zhang, Ian Mathews, Chun Peng Goh, Colin Teo, Bolem Nagarjun, Vanessa Chen, Sein Lwin, Kejia Teo, Shiong Wen Low, Ira Sy Sun, Boon Chuan Pang, Eugene Wr Yang, Cunli Yang, Anil Gopinathan, Tseng Tsai Yeo, Vincent Dw Nga
The comparability of endovascular coiling over neurosurgical clipping has not been firmly established in elderly patients with aneurysmal subarachnoid haemorrhage (aSAH). Data were obtained from all patients with aSAH aged ≥60 across three tertiary hospitals in Singapore from 2014 to 2019. Outcome measures included modified Rankin Scale (mRS) score at 3 and at 6 months, and in-hospital mortality. Of the 134 patients analyzed, 84 (62.7%) underwent coiling and 50 (37.3%) underwent clipping. The endovascular group showed a higher incidence of good mRS score 0-2 at 3 months (OR = 2...
March 1, 2024: Neurosurgical Review
https://read.qxmd.com/read/38424654/postoperative-epidural-hematoma-as-a-rare-complication-after-intracranial-tumor-resection-a-case-series-report-and-causes-analysis
#30
JOURNAL ARTICLE
Minghui Zeng, Zhijin Li, Chunsheng Xia, Xufeng Cheng, Yehan Wang, Fei Wang
BACKGROUND: To review the treatment and the causes of postoperative epidural hematoma (PEDH) after intracranial tumor resection. METHOD: A retrospective case study was conducted to examine a series of patients who developed PEDH as a complication following intracranial tumor resection between January 2016 and June 2021. The study collected data from hospital charts, including clinical status at admission, imaging results, histopathologic findings, surgical management, complications, and outcomes...
March 1, 2024: Chinese Neurosurgical Journal
https://read.qxmd.com/read/38408336/enlarged-tumefactive-perivascular-or-virchow-robin-spaces-and-hydrocephalus-do-we-need-to-treat-illustrative-cases
#31
JOURNAL ARTICLE
Belal Neyazi, Vanessa Magdalena Swiatek, Klaus-Peter Stein, Karl Hartmann, Ali Rashidi, Seraphine Zubel, Amir Amini, I Erol Sandalcioglu
BACKGROUND: Perivascular spaces (PVSs) are spaces in brain parenchyma filled with interstitial fluid surrounding small cerebral vessels. Massive enlargements of PVSs are referred to as "giant tumefactive perivascular spaces" (GTPVSs), which can be classified into three types depending on their localization. These lesions are rare, predominantly asymptomatic, and often initially misinterpreted as cystic tumor formations. However, there are several reported cases in which GTPVSs have induced neurological symptoms because of their size, mass effect, and location, ultimately leading to obstructive hydrocephalus necessitating neurosurgical intervention...
February 26, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38402132/urological-outcomes-in-post-pubertal-patients-with-myelomeningocele-a-single-center-retrospective-study
#32
JOURNAL ARTICLE
Niklas Pakkasjärvi, Sampo Antila, Eija Mäkelä, Seppo Taskinen
BACKGROUND: Recent decades have seen changes in the urological treatment of myelomeningocele (MMC). We aimed to evaluate the urological outcomes in post-pubertal patients and to clarify associations with walking status, hydrocephalus, and sex. METHODS: A retrospective study of 103 MMC patients at their final pediatric urological control. Urological procedures, the necessity for Clean Intermittent Catheterization (CIC) and anticholinergic medication, the state of continence, renal ultrasound findings, and serum creatinine values were assessed...
February 7, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38401066/clinical-characteristics-of-childhood-onset-craniopharyngioma
#33
JOURNAL ARTICLE
Lihua Tian, Liyong Zhong
OBJECTIVE: Craniopharyngioma (CP) is an intracranial congenital epithelial tumor that can occur at any age. CP tumors are histologically benign (WHO grade I), and childhood‑onset CP (CO-CP) patients have a high rate of survival. The major concern for CO-CP patients is delayed diagnosis. Delayed diagnosis can further lead to serious adverse consequences such as acute and chronic complications, thereby endangering the life of the patient.We evaluated the early-stage clinical characteristics of CO-CP patients to provide clues for making rapid and accurate diagnoses...
February 9, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38398254/clr-c-reactive-protein-to-lymphocyte-ratio-served-as-a-promising-predictive-biomarker-for-cerebral-vasospasm-in-aneurysmal-subarachnoid-hemorrhage-asah-a-retrospective-cohort-study
#34
JOURNAL ARTICLE
Ke Li, Dilaware Khan, Igor Fischer, Daniel Hänggi, Jan F Cornelius, Sajjad Muhammad
Background : Subarachnoid hemorrhage is a devastating disease. Even after state-of-the-art treatment patients suffer from complications, including cerebral vasospasm (CVS), delayed cerebral ischemia (DCI), and chronic hydrocephalus (CH) following aneurysmal subarachnoid hemorrhage (aSAH). The aim of our study is to identify the predictive value of the C-reactive protein to lymphocyte ratio (CLR) for neurological functional outcome and complications after aSAH. Methods : We retrospectively analyzed a total of 166 aSAH patients who met the inclusion criteria enrolled in our study...
February 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38394779/an-infant-type-hemispheric-glioma-with-sox5-alk-a-novel-fusion
#35
JOURNAL ARTICLE
Chia Chin Tsai, Man-Hsu Huang, Chia-Lang Fang, Kevin Li-Chun Hsieh, Tsung-Han Hsieh, Wan-Ling Ho, Hsi Chang, Min-Lan Tsai, Yu-Chien Kao, James S Miser, Tai-Tong Wong, Min-Yu Su, Yen-Lin Liu
Infant-type hemispheric glioma (IHG) is a rare pediatric brain tumor with variable response to chemotherapy and radiotherapy. Molecular insights into IHG can be useful in identifying potentially active targeted therapy. A male fetus was found to have congenital hydrocephalus at the gestational age of 37 weeks. Fetal MRI showed a 2.6 × 2.0-cm tumor located at the frontal horn of the left lateral ventricle, involving the left basal nuclei and thalamus. Tumor biopsy at the age of 2 days revealed an IHG consisting of spindle tumor cells with strong expression of GFAP and ALK...
February 2024: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/38393397/stereotactic-radiosurgery-for-koos-grade-iv-vestibular-schwannoma-a-systematic-review-and-meta-analysis
#36
JOURNAL ARTICLE
Michał Szymoniuk, Marek Kochański, Karolina Wilk, Dominika Miazga, Oliwia Kanonik, Aleksandra Dryla, Piotr Kamieniak
BACKGROUND: Stereotactic radiosurgery (SRS) is a well-established treatment option for Koos stage I-III vestibular schwannomas (VS), often used as the first line of treatment or after subtotal resection. However, the optimal treatment for Koos-IV VS remains unclear. Therefore, our study aimed to evaluate the effectiveness of SRS as a primary treatment for large VS classified as Koos-IV. METHODS: A systematic search was performed on December 28th, 2022, based on PubMed, Web of Science, and Scopus according to the PRISMA statement...
February 23, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38388693/liquid-biopsy-guides-successful-molecular-targeted-therapy-of-an-inoperable-pediatric-brainstem-neoplasm
#37
JOURNAL ARTICLE
Cecilia Arthur, Lena-Maria Carlson, Jan Svoboda, Ulrika Sandvik, Cecilia Jylhä, Magnus Nordenskjöld, Stefan Holm, Emma Tham
Midline CNS tumors are occasionally inaccessible for surgical biopsies. In these instances, cell-free DNA (cfDNA) may serve as a viable alternative for molecular analysis and identification of targetable mutations. Here, we report a young child with an inoperable brainstem tumor in whom a stereotactic biopsy was deemed unsafe. The tumor progressed on steroids and after radiotherapy the patient developed hydrocephalus and received a ventriculoperitoneal shunt. Droplet digital PCR analysis of cfDNA from an intraoperative cerebrospinal fluid liquid biopsy revealed a BRAF V600 mutation enabling targeted treatment with MEK and BRAF inhibitors...
February 22, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38386079/ventriculo-atrial-shunt-in-idiopathic-intracranial-hypertension
#38
REVIEW
Sheikh M B Momin, Sophie R Mullins, Claudia L Craven, Laurence Watkins, Ahmed K Toma
PURPOSE: CSF diversion  is a recognised intervention in idiopathic intracranial hypertension (IIH), particularly in the presence of vision-threatening papilledema. Although ventriculo-atrial (VA) shunt insertion is a routine neurosurgical procedure, ventriculoperitoneal and lumboperitoneal shunts have been mostly used in this particular indication. This study aims to look at a single centre's experience with VA shunts in idiopathic intracranial hypertension (IIH). METHODS: Retrospective case series with a review of electronic records over a 10-year period; exclusion criteria were duplication of same shunt insertion, no VA shunt insertion, paediatric patients and indication other than IIH...
February 22, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38384554/short-term-outcomes-of-robot-assisted-minimally-invasive-surgery-for-brainstem-hemorrhage-a-case-control-study
#39
JOURNAL ARTICLE
Dejun Bao, Shengyuan Ni, Bowen Chang, Wang Zhang, Hong Zhang, Chaoshi Niu
OBJECTIVE: This work focused on investigating if robot-assisted minimally invasive surgery improved middle term vital outcome for primary brainstem hemorrhage (PBSH). METHODS: This work obtained clinical data from patients with PBSH admitted from July 2019 to August 2021. All cases were classified as surgical or conservative treatment group. The general information, Glasgow coma scale (GCS) score, Glasgow outcome score (GOS), along with survival time in patients 60 days after robot-assisted surgery were recorded and analyzed...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38384393/efficacy-and-safety-of-lumbar-drainage-before-endovascular-treatment-for-ruptured-intracranial-aneurysms
#40
JOURNAL ARTICLE
Toshitsugu Terakado, Yoshiro Ito, Koji Hirata, Masayuki Sato, Tomoji Takigawa, Aiki Marushima, Mikito Hayakawa, Wataro Tsuruta, Noriyuki Kato, Yasunobu Nakai, Kensuke Suzuki, Yuji Matsumaru, Eiichi Ishikawa
OBJECTIVE: Intraoperative rebleeding during endovascular treatment for ruptured intracranial aneurysms is associated with poor prognosis. Lumbar drainage is performed preoperatively to control intracranial pressure; however, it is associated with a risk of brain herniation or rebleeding because intracranial pressure may change rapidly. Therefore, this study aimed to examine the efficacy and safety of preoperative lumbar drainage. METHODS: This retrospective study enrolled 375 patients who underwent endovascular treatment of ruptured intracranial aneurysms at our institution between April 2013 and March 2018...
2024: Journal of neuroendovascular therapy
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