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Fibrinogeno

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https://www.readbyqxmd.com/read/27215083/polymorphisms-associated-with-increased-cardiovascular-risk-in-the-general-population-do-not-predict-acute-events-in-hemodialysis-patients
#1
Roberta Rolla, Andreana De Mauri, Matteo Vidali, Ambra Valsesia, Doriana Chiarinotti, Giorgio Bellomo
BACKGROUND: Cardiovascular diseases are the leading cause of morbidity and mortality in hemodialysis patients (HP). The aim of the study was to analyze a series of polymorphisms (known to be associated with increased cardiovascular risk in the general population) in HP, in order to better understand the mechanisms of cardiovascular disease and to find new prevention strategies. METHODS: 102 hemodialysis patients were investigated for polymorphisms associated with increased cardiovascular risk in unselected population (FV Leiden R506Q; FV H1299R; FII G20210A; PAI-1 var 4G/5G; GpIIIA T1565C; FXIII var G/T; β-FIBRINOGENO var G/A; ACE I/D; AGT var M/T; ATR-1A1166C; APOE T112C; APOE T158C; MTHFR C677T; MTHFR A1298C; CBS 844ins68)...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/10896247/elastase-mediated-fibrinolysis-in-acute-promyelocytic-leukemia
#2
COMPARATIVE STUDY
E J Oudijk, H K Nieuwenhuis, R Bos, R Fijnheer
The bleeding syndrome of acute promyelocytic leukemia (APL) is complex and consists of disseminated intravascular coagulation (DIC) and hyperfibrinolysis. Elastase, derived from malignant promyelocytes, is believed to mediate the fibrinogeno- and fibrinolysis by aspecific proteolysis. In this study we measured the role of elastase in fifteen patients with APL by using an assay for elastase degraded fibrin(ogen) and the results were compared with those obtained in patients with sepsis induced DIC. High levels of elastase were observed in sepsis and APL...
June 2000: Thrombosis and Haemostasis
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