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hi-c OR hic

Yutong Zhang, Yanjun Zhang, Bo Li, Xuefei Wang, Fei Xu, Kexue Zhu, Lehe Tan, Wenjiang Dong, Zhong Chu
The effect of improved extrusion cooking technology (IECT) on jackfruit seed starch (JFSS) digestion properties was investigated by the in vitro starch hydrolysis, hydrolysis index (HI) and glycaemic index (GI). The IECT markedly increased the content of rapidly digestible starch (RDS), slowly digestible starch (SDS), equilibrium concentration (C∞ ), HI, GI, and the rate of starch digestion but decreased in resistant starch (RS). Increasing the temperature and screw speed resulted in significant increases in SDS, C∞ , HI, GI, and decreases in RDS, RS content...
October 17, 2018: International Journal of Biological Macromolecules
M Toledano, R Osorio, M-C Pérez-Álvarez, E Osorio, C-D Lynch, M Toledano-Osorio
BACKGROUND: The purpose of this study was to evaluate nanohardness and viscoelastic behavior of dentin surfaces treated with two canal sealer cements for dentin remineralization. MATERIAL AND METHODS: Dentin surfaces were subjected to: i) 37% phosphoric acid (PA) or ii) 0.5 M ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite-based cements, containing sodium hydroxide (calcypatite) or zinc oxide (oxipatite), respectively...
October 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
Mikhail Kolmogorov, Joel Armstrong, Brian J Raney, Ian Streeter, Matthew Dunn, Fengtang Yang, Duncan Odom, Paul Flicek, Thomas M Keane, David Thybert, Benedict Paten, Son Pham
Despite the rapid development of sequencing technologies, the assembly of mammalian-scale genomes into complete chromosomes remains one of the most challenging problems in bioinformatics. To help address this difficulty, we developed Ragout 2, a reference-assisted assembly tool that works for large and complex genomes. By taking one or more target assemblies (generated from an NGS assembler) and one or multiple related reference genomes, Ragout 2 infers the evolutionary relationships between the genomes and builds the final assemblies using a genome rearrangement approach...
October 19, 2018: Genome Research
Natalia A Viña, Patricia Carrascosa, Vanesa C Mogensen, Alejandro Deviggiano, Gaston Bellia-Munzon, Marcelo Martinez-Ferro, Gaston A Rodriguez-Granillo
PURPOSE: Preoperative assessment of patients with pectus excavatum (PE) demands evaluation of malformation indexes, generally with chest computed tomography (CT). In addition, assessment of the cardiac impact of sternal depression has become a rule in high referral centers, thus requiring two independent imaging modalities and use ionizing radiation in a very young population. The objective of this study was to explore the agreement between chest CT and standard cardiac MR (CMR) for the evaluation of chest wall malformation indexes...
October 15, 2018: Clinical Imaging
Zachary D Wallen, Honglei Chen, Erin M Hill-Burns, Stewart A Factor, Cyrus P Zabetian, Haydeh Payami
Objective: To identify modifiers of age at diagnosis of Parkinson disease (PD). Methods: Genome-wide association study (GWAS) included 1,950 individuals with PD from the NeuroGenetics Research Consortium (NGRC) study. Replication was conducted in the Parkinson's, Genes and Environment study, including 209 prevalent (PAGEP ) and 517 incident (PAGEI ) PD cases. Cox regression was used to test association with age at diagnosis. Individuals without neurologic disease were used to rule out confounding...
October 2018: Neurology. Genetics
Valerie Vi Thien Mac, Vicki Hertzberg, Linda A McCauley
OBJECTIVE: This study was designed to examine the associations between regional weather data and agricultural worksite temperatures in Florida. METHODS: Florida farmworkers (n = 105) were each monitored using iButton technology paired with simultaneous data from regional weather stations. Conditional inference tree models were developed for (1) regional environmental temperatures and iButton (worksite) temperatures, and (2) regional heat index (HI) and iButton HI...
October 17, 2018: Journal of Occupational and Environmental Medicine
Lana K Hiscock, Brooke Raycraft, Monika Walesa-Chorab, Coralie Cambe, Alexandre Malinge, W G Skene, Hi Taing, S Holger Eichhorn, Louise Dawe, Kenneth Maly
A series of novel tetrakis(dialkoxyphenyl) dicyanotetraoxapentacene derivatives (1a-c) were prepared by reaction of the appropriate terphenyl diols with tetrafluoroterephthalonitrile in good yields. Compounds 1b and 1c, which bear hexyloxy and decyloxy side chains, exhibit columnar hexagonal mesophases, as shown by polarized optical microscopy, variable temperature powder X-ray diffraction, and differential scanning calorimetry. Single crystal X-ray diffraction of methoxy-substituted 1a reveals that the dicyanotetraoxapentacene core is highly planar, consistent with notion that these molecules are able to stack the columnar mesophase...
October 18, 2018: Chemistry: a European Journal
Laura S M Müller, Raúl O Cosentino, Konrad U Förstner, Julien Guizetti, Carolin Wedel, Noam Kaplan, Christian J Janzen, Panagiota Arampatzi, Jörg Vogel, Sascha Steinbiss, Thomas D Otto, Antoine-Emmanuel Saliba, Robert P Sebra, T Nicolai Siegel
Many evolutionarily distant pathogenic organisms have evolved similar survival strategies to evade the immune responses of their hosts. These include antigenic variation, through which an infecting organism prevents clearance by periodically altering the identity of proteins that are visible to the immune system of the host1 . Antigenic variation requires large reservoirs of immunologically diverse antigen genes, which are often generated through homologous recombination, as well as mechanisms to ensure the expression of one or very few antigens at any given time...
October 17, 2018: Nature
Christiaan A Miermans, Chase P Broedersz
A prominent organizational feature of bacterial chromosomes was revealed by Hi-C experiments, indicating anomalously high contacts between the left and right chromosomal arms. These long-range contacts have been attributed to various nucleoid-associated proteins, including the ATPase Structural Maintenance of Chromosomes (SMC) condensin. Although the molecular structure of these ATPases has been mapped in detail, it still remains unclear by which physical mechanisms they collectively generate long-range chromosomal contacts...
October 17, 2018: Journal of the Royal Society, Interface
Tatiana Y Hargrove, Zdzislaw Wawrzak, Paxtyn M Fisher, Stella A Child, W David Nes, F Peter Guengerich, Michael R Waterman, Galina I Lepesheva
Sterol 14α-demethylases (CYP51s) are phylogenetically the most conserved cytochromes P450, whose three-step reaction is crucial for biosynthesis of sterols and serves as a leading target for clinical and agricultural antifungal agents. The structures of several (bacterial, protozoan, fungal, and human) CYP51 orthologs, in both the ligand-free and inhibitor-bound forms, have been determined and have revealed striking similarity at the secondary and tertiary structural levels, despite having low sequence identity...
October 16, 2018: Journal of Biological Chemistry
Sarah Barber, Graham Thornicroft
This mini-review considers the mortality gap in persons with severe mental disorder (SMD) globally. Current estimates of 10-20 years of potential life lost may be too conservative, both in high (HIC) and low and middle-income countries (LMICs). There is an emerging consensus that natural causes account for the majority of deaths in persons with SMD in both resource settings. In HICs, cardiovascular causes predominate, and can be attributed to individual, health-system and societal level risk factors. Psychosocial lifestyle interventions target behavior specific risk factors for physical ill-health...
2018: Frontiers in Psychiatry
Pierrick Moreau, Axel Cournac, Gianna Aurora Palumbo, Martial Marbouty, Shogofa Mortaza, Agnes Thierry, Stefano Cairo, Marc Lavigne, Romain Koszul, Christine Neuveut
Whether non-integrated viral DNAs distribute randomly or target specific positions within the higher-order architecture of mammalian genomes remains largely unknown. Here we use Hi-C and viral DNA capture (CHi-C) in primary human hepatocytes infected by either hepatitis B virus (HBV) or adenovirus type 5 (Ad5) virus to show that they adopt different strategies in their respective positioning at active chromatin. HBV contacts preferentially CpG islands (CGIs) enriched in Cfp1 a factor required for its transcription...
October 15, 2018: Nature Communications
Sohyun Jeong, Minhee Lee, Eunhee Ji
Purpose: Diabetes is a chronic lifelong condition, and adherence to medications and self-monitoring of blood glucose are challenging for diabetic patients. The dramatic increase in the prevalence of diabetes is largely due to the incidence of type 2 diabetes in low- and middle-income countries (LMIc) besides high-income countries (HIc). We aimed to evaluate whether pharmacist care (PC) service model in LMIc and HIc could improve clinical outcomes in diabetic patients by performing a meta-analysis...
2018: Therapeutics and Clinical Risk Management
Venkatesh Kumaresan, Mukesh Pasupuleti, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Aziz Arshad, S M Nurul Amin, Fatimah Md Yusoff, Jesu Arockiaraj
Snakehead murrel, Channa striatus is an economically important aquatic species in Asia and are widely cultured and captured because of its nutritious and medicinal values. Their growth is predominantly affected by epizootic ulcerative syndrome (EUS) which is primarily caused by an oomycete fungus, Aphanomyces invadans. However, the molecular mechanism of immune response in murrel against this infection is still not clear. In this study, transcriptome technique was used to understand the molecular changes involved in C...
October 11, 2018: Molecular Biology Reports
Chang Su, Xue-Jun Liang, Wen-Jing Li, Di Wu, Min Liu, Bing-Yan Cao, Jia-Jia Chen, Miao Qin, Xi Meng, Chun-Xiu Gong
Objective: To characterize the genotype and phenotype of Chinese patients with congenital hyperinsulinism (CHI) caused by activating mutations in GLUD1 , the gene that encodes mitochondrial enzyme glutamate dehydrogenase (GDH). Methods: The clinical data of glutamate dehydrogenase hyperinsulinism (GDH-HI) patients were reviewed, and gene mutations were confirmed by whole exome sequencing (WES) and Sanger DNA sequencing. Results: Twenty-six patients with GDH-HI heterozygous missense mutations were identified from 240 patients diagnosed as congenital hyperinsulinism over past 15 years...
2018: Journal of Diabetes Research
Xiaogai Li, Svein Kleiven
Playground-related traumatic brain injuries (TBIs) in children remain a considerable problem world-wide and current safety standards are being questioned due to historical reasons where the injury thresholds had been perpetuated from automobile industry. Here we investigated head injury mechanisms due to falls on playgrounds using a previously developed and validated age-scalable and positionable whole body child model impacted at front, back and side of the head simulating head-first falls from 1.59 meters (m)...
October 10, 2018: Scientific Reports
Stefan Schoenfelder, Borbala Mifsud, Claire E Senner, Christopher D Todd, Stephanie Chrysanthou, Elodie Darbo, Myriam Hemberger, Miguel R Branco
The establishment of the embryonic and trophoblast lineages is a developmental decision underpinned by dramatic differences in the epigenetic landscape of the two compartments. However, it remains unknown how epigenetic information and transcription factor networks map to the 3D arrangement of the genome, which in turn may mediate transcriptional divergence between the two cell lineages. Here, we perform promoter capture Hi-C experiments in mouse trophoblast (TSC) and embryonic (ESC) stem cells to understand how chromatin conformation relates to cell-specific transcriptional programmes...
October 10, 2018: Nature Communications
Khachen Kongpakwattana, Piyameth Dilokthornsakul, Charungthai Dejthevaporn, Oraluck Pattanaprateep, Nathorn Chaiyakunapruk
AIMS: Due to lack of study evaluating compliance or persistence with Alzheimer's Disease (AD) treatment outside High-Income Countries (HICs), we aimed to assess compliance, persistence and factors associated with non-compliance and non-persistence by utilizing existing 'real-world' information from multiregional hospital databases in Thailand. MATERIALS AND METHODS: We retrospectively identified study subjects from databases of five hospitals located in different regions across Thailand...
October 10, 2018: Journal of Medical Economics
Nicola J Robertson, Kathryn Martinello, Ingran Lingam, Adnan Avdic-Belltheus, Christopher Meehan, Daniel Alonso-Alconada, Sara Ragab, Alan Bainbridge, Magdalena Sokolska, Mohamed Tachrount, Benita Middleton, David Price, Mariya Hristova, Xavier Golay, Annamaria Soliani Raschini, Giancarlo Aquino, Nicola Pelizzi, Fabrizio Facchinetti
Therapeutic hypothermia is only partially protective for neonatal encephalopathy; there is an urgent need to develop treatments that augment cooling. Our objective was to assess safety, efficacy and pharmacokinetics of 5 and 15 mg/kg/24 h melatonin (proprietary formulation) administered at 2 h and 26 h after hypoxia-ischemia (HI) with cooling in a piglet model. Following moderate cerebral HI, 30 piglets were eligible and randomized to: i) Hypothermia (33.5 °C, 2-26 h) and vehicle (HT + V;n = 13); b) HT and 5 mg/kg melatonin over 6 h at 2 h and 26 h after HI (HT + Mel-5;n = 4); c) HT and 15 mg/kg melatonin over 6 h at 2 h and 26 h after HI (HT + Mel-15;n = 13)...
October 6, 2018: Neurobiology of Disease
Roberta Zappasodi, Sadna Budhu, Matthew D Hellmann, Michael A Postow, Yasin Senbabaoglu, Sasikanth Manne, Billel Gasmi, Cailian Liu, Hong Zhong, Yanyun Li, Alexander C Huang, Daniel Hirschhorn-Cymerman, Katherine S Panageas, E John Wherry, Taha Merghoub, Jedd D Wolchok
No abstract text is available yet for this article.
October 8, 2018: Cancer Cell
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