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Fetal Cleft lip

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https://www.readbyqxmd.com/read/30280914/parental-views-of-antenatal-testing-and-termination-following-a-diagnosis-of-cleft-lip
#1
Nicola Marie Stock, Bruna Costa, Jenny Williams, Anna Martindale, The Vtct Foundation Research Team At The Centre For Appearance Research
Fetal anomaly screening at 18-21 weeks now routinely includes cleft lip. If detected, the manner in which the diagnosis is communicated can considerably influence prospective parents' decision-making in regard to further testing and termination of pregnancy (TOP). Given the known psychological impact of an antenatal diagnosis of cleft lip on prospective parents, this study aimed to explore the decision-making process from the parents' perspective, in order to evaluate how well current practice is meeting guidelines...
October 3, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/30252164/a-morphometric-analysis-of-developmental-instability-in-children-born-with-unilateral-cleft-lip-and-palate
#2
Kristyna Ceuninck, John M Starbuck
INTRODUCTION: Unilateral cleft lip and palate (UCLP) is a congenital deformity that occurs due to inadequate merging of the nasal and maxillary prominences during fetal development. Randomly distributed bilateral asymmetries known as fluctuating asymmetry (FA) occur in normally symmetric organisms when evolved mechanisms of developmental stability or equilibrium are disturbed by genetic, environmental, or unknown factors. Here we hypothesize that facial skeleton FA will be increased in a sample of individuals born with UCLP (n = 24) relative to sex- and age-matched controls (n = 24)...
September 25, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/30132143/fetal-dental-panorama-on-three-dimensional-ultrasound-imaging-of-cleft-lip-and-palate-and-other-facial-anomalies
#3
Romain Nicot, Daniel Rotten, Yasmin Opdenakker, Bothild Kverneland, Joël Ferri, Gérard Couly, Jean-Marc Levaillant
OBJECTIVES: Craniofacial deformities have a high psychosocial impact. The aim of this paper is to improve obstetric ultrasonography and prenatal detection of facial anomalies by providing a new fetal dental panorama. MATERIAL AND METHODS: The present study describes a new modality to visualize the fetal tooth germs and an easy step-by-step diagnostic approach. Image acquisition was performed between 23 and 32 weeks of gestation using a Voluson E10 GE ultrasound machine with an RM6C transducer (GE Medical Systems, Zipf, Austria)...
August 21, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/30127215/genome-wide-screening-of-aberrant-methylation-loci-for-nonsyndromic-cleft-lip
#4
Xiao-Yan Xu, Xiao-Wei Wei, Wei Ma, Hui Gu, Dan Liu, Zheng-Wei Yuan
Background: The pathogenicity of cleft lip (CL) is pretty complicated since it is influenced by the interaction of environment and genetic factors. The purpose of this study was to conduct a genome-wide screening of aberrant methylation loci in partial lesion tissues of patients with nonsyndromic CL (NSCL) and preliminarily validate candidate dysmethylated genes associated with NSCL. Methods: Fifteen healthy and sixteen NSCL fetal lip tissue samples were collected...
September 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/30079491/infraorbital-foramen-location-in-the-pediatric-population-a-guide-for-infraorbital-nerve-block
#5
Matthew J Zdilla, Michelle L Russell, Aaron W Koons
BACKGROUND: Infraorbital nerve blocks are often performed for the management of postoperative pain associated with cleft lip correction. Infraorbital nerve block procedures depend on the identification of the infraorbital foramen; however, there is little information regarding the infraorbital foramen location in the pediatric population. AIMS: The aim of this study was to identify the location of the infraorbital foramen in the pediatric population relative to a midpoint between the nasospinale and jugale...
August 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/30067525/importance-of-stem-cell-transplantation-in-cleft-lip-and-palate-surgical-treatment-protocol
#6
Marcelo Paulo Vaccari Mazzetti, Nivaldo Alonso, Ryane Schmidt Brock, Alexandre Ayoub, Sally Mizukami Massumoto, Lilian Piñero Eça
Cleft lip and palate is a congenital malformation that requires a multidisciplinary treatment that evolves pediatrician, obstetrics, fetal medicine, genetics, plastic surgery, orthodontics, speech therapist, nursery, and psychology. Actually, the authors believe that it could be possible to ad protocols to use stem cells.The intrauterine diagnosis leads to preborn parental orientation and better parental collaboration to accept a precocious multidisciplinary treatment. After birth the authors' protocol is: orthodontic devices, phonoaudiology, and surgical procedures...
July 31, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30055034/expanding-the-fetal-phenotype-prenatal-sonographic-findings-and-perinatal-outcomes-in-a-cohort-of-patients-with-a-confirmed-22q11-2-deletion-syndrome
#7
Erica Schindewolf, Nahla Khalek, Mark P Johnson, Juliana Gebb, Beverly Coleman, Terrence Blaine Crowley, Elaine H Zackai, Donna M McDonald-McGinn, Julie S Moldenhauer
22q deletion syndrome (22q11.2DS) is most often correlated prenatally with congenital heart disease and or cleft palate. The extracardiac fetal phenotype associated with 22q11.2DS is not well described. We sought to review both the fetal cardiac and extracardiac findings associated with a cohort of cases ascertained prenatally, confirmed or suspected to have 22q11.2DS, born and cared for in one center. A retrospective chart review was performed on a total of 42 cases with confirmed 22q11.2DS to obtain prenatal findings, perinatal outcomes and diagnostic confirmation...
August 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/30024536/alobar-holoprosencephaly-associated-with-a-rare-chromosomal-abnormality-case-report-and-literature-review
#8
REVIEW
Crîngu Antoniu Ionescu, Dan Calin, Dan Navolan, Alexandra Matei, Mihai Dimitriu, Catalin Herghelegiu, Liana Ples
RATIONALE: Holoprosencephaly is a structural malformation of the brain that results from the complete or incomplete noncleavage of the forebrain of the embryo into 2 hemispheres. We report a severe case of alobar holoprosencephaly diagnosed at 38 weeks, associated with cebocephaly, microcephaly, and craniosynostosis. PATIENT CONCERN: The main knowledge added by this case is the late ultrasound diagnosis and chromosomal analysis that revealed a very rare abnormality (45X/46,XX/47,XX) with mosaicism at chromosome 18...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29964326/a-score-based-method-for-quality-control-of-fetal-hard-palate-assessment-during-routine-second-trimester-ultrasound-examination
#9
Florent Fuchs, Julie Burlat, Fréderic Grosjean, Romy Rayssiguier, Guillaume Captier, Jean-Michel Faure, Coralie Dumont
INTRODUCTION: When an orofacial cleft lip is discovered, precise characterization of this malformation is necessary, especially the extension of this cleft to the secondary palate. We aimed to develop and evaluate the feasibility/reproducibility of a score-based quality control for the visualization of the fetal hard palate during the second-trimester scan. MATERIAL AND METHODS: All ultrasound images of fetal hard palate assessed routinely during second-trimester scan were retrospectively retrieved for a 6-month period...
November 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29859779/could-fetal-reduction-induce-facial-cleft-report-of-a-case
#10
J Chauvel-Picard, J Massardier, A Gleizal
We describe a paramedian cleft of the lower lip that cannot be explained by embryological development in a child with only one predisposing factor, which was fetal reduction for a multiple pregnancy. To the best of our knowledge, there has been no report of a cleft that has been induced by the reduction of a multifetal pregnancy.
July 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29788402/internationally-adopted-children-not-only-infectious-diseases
#11
Camilla Totaro, Barbara Bortone, Pasqua Putignano, Sara Sollai, Luisa Galli, Maurizio de Martino, Elena Chiappini
Information on prevalence of special needs in internationally adopted children (IAC) is incomplete. We reviewed data from 422 IAC screened at a single Centre in Italy in 2015-16. Prevalence of special needs reached 17.1% (n = 72). Among these children, the most frequent conditions were fetal alcohol spectrum disorders (FASD; n = 30; 7.1%), cleft lip palate (n = 8; 1.9%) and other congenital malformations (n = 20; 4.7%). Worrisomely, 25 out of 52 (48.1%) Russian children presented with FASD.
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29777898/a-survey-of-health-professionals-views-on-acceptable-gestational-age-and-termination-of-pregnancy-for-fetal-anomaly
#12
Lisa Crowe, Ruth H Graham, Stephen C Robson, Judith Rankin
Termination of pregnancy for fetal anomaly is legal in the UK with no upper limit, if two doctors, in good faith, agree "there is a substantial risk that if the child were born it would suffer from such physical or mental abnormalities as to be seriously handicapped". This is Clause E of the Human Fertlisation and Embryology Act. The most commonly sighted Clause is C, which states "the pregnancy has not exceeded its twenty-fourth week and that the continuance of the pregnancy would involve risk, greater than if the pregnancy were terminated, of injury to the physical or mental health of the pregnant woman"...
September 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29753919/epidemiology-of-orofacial-clefts-in-a-danish-county-over-35-years-before-and-after-implementation-of-a-prenatal-screening-programme-for-congenital-anomalies
#13
Eva Berenth Paaske, Ester Garne
In 2004 the Danish National Board of Health changed its screening recommendations. Since 2005 a first trimester screening for Down syndrome and a prenatal ultrasound screening for congenital anomalies in the second trimester of pregnancy has been offered to all pregnant women. The aim of this study was to describe the prevalence of cleft lip with or without cleft palate and cleft palate in a Danish area and to describe associated anomalies and the development in prenatal diagnosis over time. The study was based on data from the EUROCAT Registry for Funen County...
September 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29720579/congenital-esophageal-atresia-and-microtia-in-a-newborn-secondary-to-mycophenolate-mofetil-exposure-during-pregnancy-a-case-report-and-review-of-the-literature
#14
REVIEW
Musaed Mohammed Alsebayel, Faisal Abdulrahman Abaalkhail, Faisal Mohammed Alsebayel, Dema A Alissa, Ahmed Hamdan Al-Jedai, Hussien Elsiesy
BACKGROUND Mycophenolate mofetil (MMF) is one of the most commonly prescribed drugs to prevent organ transplant rejection in combination with calcineurin inhibitors and steroids. It has a different toxicity profile than tacrolimus and cyclosporine.  Gastrointestinal tract disturbances are the most common adverse effects. The use of MMF in pregnant women, however, holds great risk of miscarriage and fetal development defects such as external ear malformation, ocular anomalies, cleft lip and palate, and abnormality of distal limbs, heart, esophagus, and kidneys...
May 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29679736/para-commissural-cleft-of-the-lower-lip-a-first-case-described-in-the-literature
#15
J Chauvel-Picard, A Gleizal
We described the first case of para-commissural cleft of the lower lip in a 2 year-old child. He is from a trichorionic triamniotic triplet pregnancy after ovarian stimulation. He has no history except a selective fetal reduction of the mother. We correct this cleft of the lower lip with a double plasty of Malek. The functional and aesthetic result is satisfactory. This particular cleft cannot be explained by the embryological theory. We favor two hypothesis to explain this anomaly: a vascular origin with the stapedial artery and the selective fetal reduction...
April 19, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29653001/-genetic-analysis-of-two-fetuses-with-congenital-heart-defects-and-3q-microdeletion
#16
Wei Long, Jiandong Gu, Jun Ouyang, Saiyu Jia, Bin Zhang, Jianbin Liu, Bin Yu
OBJECTIVE: To determine the nature of genomic copy number variations (CNVs) in two fetuses with congenital heart defects (CHD) and explore the correlation between 3q microdeletions and CHD. METHODS: Genomic DNA was extracted from fetal umbilical cord tissue, and chromosome copy number variations were detected by low coverage whole genome sequencing. RESULTS: Both fetuses had microdeletions of the long arm of chromosome 3. Fetus 1 had ventricular septal defect, cleft lip and palate, and a 1...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29652578/mr-imaging-of-the-fetal-face-comprehensive-review
#17
REVIEW
Murali Nagarajan, Kedar G Sharbidre, Sudeep H Bhabad, Sharon E Byrd
The human face is a complex anatomic structure with an equally complex embryologic development. Derangement of the developmental process can result in various structural anomalies, which range from a mainly cosmetic deformity, such as cleft lip, to potentially life-threatening conditions such as arhinia. These anomalies (a) can occur as isolated anomalies; (b) can be associated with intracranial, spinal, or dental anomalies; or (c) can be a part of various syndromes, thus serving as diagnostic clues in such cases...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29614471/maternal-exposure-to-ambient-air-pollutant-and-risk-of-oral-clefts-in-wuhan-china
#18
Jinzhu Zhao, Bin Zhang, Shaoping Yang, Hui Mei, Zhengmin Qian, Shengwen Liang, Yiming Zhang, Ke Hu, Yafei Tan, Hong Xian, Rhonda Belue, Savannah S Jordan, Shunqing Xu, Tongzhang Zheng, Yukai Du
Maternal exposure to ambient air pollution has been related to oral clefts in offspring; however, the epidemiologic evidence is equivocal. Especially, the association between high levels of exposure to ambient air pollution during pregnancy and oral clefts remains unclear. The objective of this study was to evaluate whether high levels of maternal exposure to PM2.5 , PM10 , O3 , CO and SO2 are related to increased risk of oral clefts in Wuhan, China. A population-based study was conducted using cohort of 105,927 live-born infants, fetal deaths, and stillbirths during a two-year period from 2011 to 2013...
July 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29568912/clinical-study-of-prenatal-ultrasonography-combined-with-t%C3%A2-box-transcription-factor-1-as-a-biomarker-for-the-diagnosis-of-congenital-heart-disease
#19
Bingcheng Guo, Jing Xiao, Long Li, Shuanglong Wang, Lijuan Wang, Shuyong Liu
Congenital heart disease (CHD) seriously threatens fetal health. Therefore, prenatal examination to detect deformity is extremely important. The present study aimed to investigate the clinical application value of prenatal ultrasonography combined with molecular biology methods in the diagnosis of fetal CHD. A total of 1,000 pregnant women who had received fetal ultrasonography to examine fetal CHD were enrolled. Ultrasounds were performed for fetal heart examination and diagnosis, mainly on fetal heart position, size, structure and function, and heart valve morphology and function...
May 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29460382/an-algorithm-for-predicting-robin-sequence-from-fetal-mri
#20
Cory M Resnick, Tessa D Kooiman, Carly E Calabrese, David Zurakowski, Bonnie L Padwa, Maarten J Koudstaal, Judy A Estroff
BACKGROUND: Infants with Robin sequence (RS) may present with airway compromise at delivery. Prenatal diagnosis would improve preparation and postnatal care. The purpose of this study was to devise a predictive algorithm for RS based on fetal magnetic resonance imaging (MRI). METHODS: Retrospective case-control study including fetal MRIs from 2002 to 2017. Inclusion criteria were (1) MRI of adequate quality, (2) live-born infant, and (3) postnatal evaluation. Subjects were grouped on the basis of postnatal diagnosis: (1) RS (micrognathia, glossoptosis, airway obstruction), (2) micrognathia without airway obstruction ("micrognathia"), (3) cleft lip and palate ("CLP"), and (4) gestational age-matched controls...
April 2018: Prenatal Diagnosis
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