Olivia Masse, Olivia Brumfield, Esha Ahmad, Clemente Velasco-Annis, Jennings Zhang, Caitlin K Rollins, Susan Connolly, Carol Barnewolt, Alireza A Shamshirsaz, Shohra Qaderi, Ali Javinani, Simon K Warfield, Edward Yang, Ali Gholipour, Henry A Feldman, Patricia E Grant, John B Mulliken, Lana Pierotich, Judy Estroff
Cleft lip/palate is a common orofacial malformation that often leads to speech/language difficulties as well as developmental delays in affected children, despite surgical repair. Our understanding of brain development in these children is limited. This study aimed to analyze prenatal brain development in fetuses with cleft lip/palate and controls. We examined in utero MRIs of 30 controls and 42 cleft lip/palate fetal cases and measured regional brain volumes. Cleft lip/palate was categorized into groups A (cleft lip or alveolus) and B (any combination of clefts involving the primary and secondary palates)...
January 31, 2024: Cerebral Cortex