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Sleep and cancer

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https://www.readbyqxmd.com/read/28319090/a-single-copy-sleeping-beauty-transposon-mutagenesis-screen-identifies-new-pten-cooperating-tumor-suppressor-genes
#1
Jorge de la Rosa, Julia Weber, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Aurora Astudillo, María Teresa Fernández-García, María Soledad Fernández-García, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Carlos López-Otín, Allan Bradley, Juan Cadiñanos
The overwhelming number of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. Here we developed a novel whole-body insertional mutagenesis screen in mice, which was designed for the discovery of Pten-cooperating tumor suppressors. Toward this aim, we coupled mobilization of a single-copy inactivating Sleeping Beauty transposon to Pten disruption within the same genome. The analysis of 278 transposition-induced prostate, breast and skin tumors detected tissue-specific and shared data sets of known and candidate genes involved in cancer...
March 20, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28314544/comprehensive-assessments-of-long-term-sleep-habits-in-epidemiological-study-validity-and-reliability-of-sleep-factors-questionnaire-sfq-among-chinese-women
#2
Wan-Shui Yang, Wen-Xue Fu, Xin Wang, Qin Deng, Ling Wang, Lin-Yan Wang, Hao Zhao, Wen-Yan Fan, Shao-Xin Huang
OBJECTIVE: Epidemiological studies suggested that poor sleep is a potentially novel risk factor for several health outcomes currently; however, there are no validated questionnaires that can systematically measure sleep parameters within these studies. We evaluated the reliability and validity of 17-item sleep factors questionnaire (SFQ), which was developed to comprehensively assess long-term sleep habits for the Jiujiang Breast Cancer Study (JBCS), Jiujiang, China. METHODS: The participants included 100 women aged 18-74years, who were randomly selected from the JBCS project, and completed a SFQ at baseline and again 1year later, and 4 quarterly 30 consecutive days (a total of 120days) sleep diaries over this same year...
April 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28301036/factors-associated-with-poor-sleep-quality-in-women-with-cancer
#3
Thalyta Cristina Mansano-Schlosser, Maria Filomena Ceolim
Objectives: to analyze the factors associated with poor sleep quality, its characteristics and components in women with breast cancer prior to surgery for removing the tumor and throughout the follow-up. Method: longitudinal study in a teaching hospital, with a sample of 102 women. The following were used: a questionnaire for sociodemographic and clinical characterization, the Pittsburgh Sleep Quality Index; the Beck Depression Inventory; and the Herth Hope Scale...
March 2, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28300223/role-of-cyclooxygenase-2-on-intermittent-hypoxia-induced-lung-tumor-malignancy-in-a-mouse-model-of-sleep-apnea
#4
Noelia Campillo, Marta Torres, Antoni Vilaseca, Paula Naomi Nonaka, David Gozal, Jordi Roca-Ferrer, César Picado, Josep Maria Montserrat, Ramon Farré, Daniel Navajas, Isaac Almendros
An adverse role for obstructive sleep apnea (OSA) in cancer epidemiology and outcomes has recently emerged from clinical and animal studies. In animals, intermittent hypoxia (IH) mimicking OSA promotes tumor malignancy both directly and via host immune alterations. We hypothesized that IH could potentiate cancer aggressiveness through activation of the cyclooxygenase-2 (COX-2) pathway and the concomitant increases in prostaglandin E2 (PGE2). The contribution of the COX-2 in IH-induced enhanced tumor malignancy was assessed using celecoxib as a COX-2 specific inhibitor in a murine model of OSA bearing Lewis lung carcinoma (LLC1) tumors...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28297820/-the-mechanism-of-obstructive-sleep-apnea-promoting-cancer-development-and-progression
#5
M L Liang, L Li, J Cao
No abstract text is available yet for this article.
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28294068/cognitive-impacts-of-estrogen-treatment-in-androgen-deprived-males-what-needs-to-be-resolved
#6
Erik Wibowo
BACKGROUND: Many prostate cancer (PCa) patients are on androgen deprivation therapy (ADT) as part of their cancer treatments but ADT may cause cognitive impairments. ADT depletes men of both androgen and estrogen. Whether estradiol supplementation can improve cognitive impairments in patients on ADT is understudied. OBJECTIVE: To summarize data on the effects of estradiol treatment on cognitive function of androgen-deprived genetic male populations (PCa patients and male-to-female transsexuals) and castrated male animals...
March 13, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28288595/mindful-yoga-for-women-with-metastatic-breast-cancer-design-of-a-randomized-controlled-trial
#7
James W Carson, Kimberly M Carson, Maren K Olsen, Linda Sanders, Laura S Porter
BACKGROUND: Women with metastatic breast cancer (MBC) have average life expectancies of about 2 years, and report high levels of disease-related symptoms including pain, fatigue, sleep disturbance, psychological distress, and functional impairment. There is growing recognition of the limitations of medical approaches to managing such symptoms. Yoga is a mind-body discipline that has demonstrated a positive impact on psychological and functional health in early stage breast cancer patients and survivors, but has not been rigorously studied in advanced cancer samples...
March 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28284516/-factors-involved-in-the-burden-of-the-primary-caregiver-of-cancer-patients
#8
M C Valencia, G Meza-Osnaya, I Pérez-Cruz, N Cortes-Campero, J Hernández-Ovalle, P Hernández-Paredes, K Juárez-Romero, B Chino-Hernández, M S Romero-Figueroa
OBJECTIVE: The aim of the study was to identify the factors involved between burden in the primary caregiver of cancer patients and their quality of life. MATERIAL AND METHODS: A cross-sectional study was conducted in a secondary level hospital on 100 primary caregivers of cancer patients. The level of burden was determined using the Zarit scale and the perception of quality of life using the World Health Organisation Quality of Life questionnaire. Quality of life was categorised as high or low and compared between groups according to their level of burden...
March 8, 2017: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/28282238/changes-in-the-sleep-wake-rhythm-sleep-quality-mood-and-quality-of-life-of-patients-receiving-treatment-for-lung-cancer-a-longitudinal-study
#9
Wen-Pei Chang, Chia-Chin Lin
Studies on the diurnal sleep-wake rhythm of patients with lung cancer have mostly examined patients cross-sectionally, whereas the effects of lung cancer treatment over time have rarely been considered. Through long-term longitudinal tracking of patients with lung cancer, this study examined changes in their sleep-wake rhythm, sleep quality, anxiety, depressive symptoms, fatigue and quality of life (QoL) at various treatment stages. In addition, factors affecting their QoL were explored. Hierarchical linear modeling was adopted to analyze a convenience sample of 82 patients with lung cancer...
March 10, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28281052/interest-of-an-auto-adjustable-nighttime-compression-sleeve-mobiderm%C3%A2-autofit-in-maintenance-phase-of-upper-limb-lymphedema-the-marilyn-pilot-rct
#10
S Mestre, C Calais, G Gaillard, M Nou, M Pasqualini, C Ben Amor, I Quere
PURPOSE: Breast cancer-related lymphedema (BCRL) is a debilitating condition. The recommended treatment is based on decongestive lymphedema therapy (DLT) with two separate phases: a short-term intensive phase to reduce lymphedema volume and a long-term maintenance phase to stabilize it. Optimizing compression therapy and compliance during maintenance phase are key factors for long-term control of lymphedema. The primary objective of this pilot prospective open-label randomized study was to assess the benefit of a new auto-adjustable nighttime arm sleeve (MOBIDERM® Autofit) on lymphedema volume during the maintenance phase after the intensive phase...
March 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28281049/modifiable-and-non-modifiable-characteristics-associated-with-sleep-disturbance-in-oncology-outpatients-during-chemotherapy
#11
Sueann Mark, Janine Cataldo, Anand Dhruva, Steven M Paul, Lee-May Chen, Marilyn J Hammer, Jon D Levine, Fay Wright, Michelle Melisko, Kathryn Lee, Yvette P Conley, Christine Miaskowski
PURPOSE: In a sample of outpatients with breast, gastrointestinal, gynecological, and lung cancer who received at least two cycles of chemotherapy (CTX), the purposes were to evaluate for inter-individual differences in the severity of sleep disturbance and determine which demographic, clinical, and symptom characteristics were associated with initial levels as well as the trajectories of sleep disturbance. METHODS: A total of 1331 patients completed study questionnaires in their homes, at six time points over two cycles of CTX (prior to CTX administration, approximately 1 week after CTX administration, and approximately 2 weeks after CTX administration)...
March 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28280616/differences-in-symptom-occurrence-severity-and-distress-ratings-between-patients-with-gastrointestinal-cancers-who-received-chemotherapy-alone-or-chemotherapy-with-targeted-therapy
#12
Ilufredo Y Tantoy, Anand Dhruva, Janine Cataldo, Alan Venook, Bruce A Cooper, Steven M Paul, Jon D Levine, Yvette P Conley, Frances Cartwright, Kathryn Lee, Fay Wright, Christine Miaskowski
BACKGROUND: Approximately 28% of patients with gastrointestinal (GI) cancers will receive targeted therapy (TT) because of the associated increases in survival. Only four studies have examined the symptom experience of these patients. To date, no studies have evaluated for differences in symptom occurrence, severity, and distress between patients who received chemotherapy (CTX) alone (n=304) or CTX with TT (n=93). METHODS: Patients completed self-report questionnaires, approximately one week after they received CTX...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28279153/the-association-between-biochemical-control-and-cardiovascular-risk-factors-in-acromegaly
#13
John D Carmichael, Michael S Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P Neary, Vivien Bonert
BACKGROUND: The study aim was to estimate the proportion of acromegaly patients with various comorbidities and to determine if biochemical control was associated with reduced proportion of cardiovascular risk factors. METHODS: Data were from a single-center acromegaly registry. Study patients were followed for ≥12 months after initial treatment. Study period was from first to last insulin-like growth factor-I and growth hormone tests. RESULTS: Of 121 patients, 55% were female...
March 9, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28274539/the-clinical-impact-of-major-comorbidities-on-idiopathic-pulmonary-fibrosis
#14
REVIEW
Atsushi Suzuki, Yasuhiro Kondoh
Idiopathic pulmonary fibrosis (IPF) is a progressive and devastating disease with a median survival time of 2-3 years after diagnosis. Patients with IPF exhibit distinct patterns of disease progression, and some patients display a more rapidly progressive clinical course. The clinical course of IPF may also include periods of acute deterioration, which are termed acute exacerbations. Patients with IPF frequently experience various comorbidities, such as pulmonary infection, emphysema, pulmonary hypertension, lung cancer, gastroesophageal reflux, cardiovascular disease, diabetes mellitus, and obstructive sleep apnea...
March 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28273073/src-2-mediated-coactivation-of-anti-tumorigenic-target-genes-suppresses-myc-induced-liver-cancer
#15
Shruthy Suresh, Deniz Durakoglugil, Xiaorong Zhou, Bokai Zhu, Sarah A Comerford, Chao Xing, Xian-Jin Xie, Brian York, Kathryn A O'Donnell
Hepatocellular carcinoma (HCC) is the fifth most common solid tumor in the world and the third leading cause of cancer-associated deaths. A Sleeping Beauty-mediated transposon mutagenesis screen previously identified mutations that cooperate with MYC to accelerate liver tumorigenesis. This revealed a tumor suppressor role for Steroid Receptor Coactivator 2/Nuclear Receptor Coactivator 2 (Src-2/Ncoa2) in liver cancer. In contrast, SRC-2 promotes survival and metastasis in prostate cancer cells, suggesting a tissue-specific and context-dependent role for SRC-2 in tumorigenesis...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28272741/self-reported-sleep-disturbance-and-survival-in-myelodysplastic-syndromes
#16
Marlise R Luskin, Angel M Cronin, Robert L Owens, Daniel J DeAngelo, Richard M Stone, Martha Wadleigh, David P Steensma, Gregory A Abel
Neither the prevalence of sleep disturbance nor its association with fatigue and overall survival (OS) are well understood for patients with myelodysplastic syndromes (MDS). New patients at our institution (n = 251; 2006-2014) completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, which includes questions about sleep and fatigue. Fifty-three per cent reported at least 'a little' trouble sleeping. In multivariable models, anaemia and sleep disturbance were associated with fatigue (both P < 0·001)...
March 8, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28272340/factors-which-influence-owners-when-deciding-to-use-chemotherapy-in-terminally-ill-pets
#17
Jane Williams, Catherine Phillips, Hollie Marie Byrd
Chemotherapy is a commonly integrated treatment option within human and animal oncology regimes. Limited research has investigated pet owners' treatment decision-making in animals diagnosed with malignant neoplasia. Dog and cat owners were asked to complete an online questionnaire to elucidate factors which are key to the decision making process. Seventy-eight respondents completed the questionnaire in full. Fifty-eight percent of pet owners would not elect to treat pets with chemotherapy due to the negative impact of the associated side effects...
March 7, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28271765/how-to-promote-patients-sleep-in-hospital
#18
Irene Gilsenan
Rationale and key points Disturbed or disrupted sleep is associated with adverse effects on physical and psychological health. This article explores the importance of promoting patients' sleep in hospital, although some of the principles can be applied to other healthcare settings. Sleep is essential to recovery and well-being, and nurses are well placed to support patients to achieve and sustain sleep. » Sleep has a restorative function and is particularly important in maintaining patients' health and well-being...
March 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28264740/testing-the-feasibility-of-using-the-edmonton-symptom-assessment-system-esas-to-assess-caregiver-symptom-burden
#19
Kimberson Tanco, Marieberta Vidal, Joseph Arthur, Marvin Delgado Guay, David Hui, Diane Liu, Gary Chisholm, Eduardo Bruera
OBJECTIVE: Caregiver symptom assessment is not part of regular clinical cancer care. The ESAS (Edmonton Symptom Assessment System) is a multidimensional tool regularly used to measure symptom burden in patients but not caregivers. The objectives of the present study were to determine the feasibility of the ESAS in caregiver completion (defined as ≥ 9 of 12 items) and determine its concurrent validity with the Zarit Burden Interview-12 (ZBI-12). METHOD: We conducted a prospective study on 90 patient-primary caregiver dyads seen in an outpatient supportive care center in a cancer center...
March 7, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28261340/integrative-oncology-physician-consultations-at-a-comprehensive-cancer-center-analysis-of-demographic-clinical-and-patient-reported-outcomes
#20
Gabriel Lopez, Jennifer McQuade, Lorenzo Cohen, Jane T Williams, Amy R Spelman, Bryan Fellman, Yisheng Li, Eduardo Bruera, Richard T Lee
Background: Integrative oncology (IO) is a relatively new field that seeks to bring evidence-based, non-conventional approaches into conventional oncology care in a coordinated and safe manner. Though complementary and alternative medicine (CAM) are highly utilized by cancer patients, little is known about the characteristics of patients seeking IO consultation. Methods: Patients presenting for an outpatient IO consultation completed a CAM use questionnaire, Measure Yourself Concerns and Wellbeing (MYCaW), Edmonton Symptom Assessment Scale (ESAS), Quality of Life Short Form 12 (SF-12), and post-consultation satisfaction item...
2017: Journal of Cancer
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