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Gaby N Moawad, Paul Tyan, Charbel Awad
STUDY OBJECTIVE: In this surgical tutorial, we present technical pointers and suggestions that would enable gynecologic surgeons to achieve difficult tissue containment and extraction for numerous and large myomas in the complex minimally invasive myomectomy setting. DESIGN: A step by-step explanation of the surgery using video (instructive video), exempt by the local Institutional Review Board. (Canadian Task Force classification level III). IRB approval was not required for this study...
October 10, 2018: Journal of Minimally Invasive Gynecology
Yamini Satyawali, David Fernandes Del Pozo, Pieter Vandezande, Ingmar Nopens, Winnie Dejonghe
Hydrophobic pervaporation, allowing for the separation of an organic component from an aqueous stream, was investigated for in-situ acetone removal from a transamination reaction. A PDMS (PolyDiMethylSiloxane) membrane was applied in a coupled enzymatic process at 5 L scale. Among the four components, there was no loss of donor and product amines through pervaporation which was highly desirable. However, in addition to removal of acetone, there was also an unwanted loss of acetophenone (substrate ketone) due to pervaporation...
October 13, 2018: Biotechnology Progress
Jianfeng Zheng, Rui Xu, Guojing Liu, Zongduo Guo, Xiaochuan Sun
OBJECTIVE: Hypertension is common in patients with aneurysmal subarachnoid hemorrhage (SAH). However, it is still unclear whether premorbid antihypertensive therapy can help to reduce the risk of severe aneurysmal bleeding. Therefore, this study aims to assess the effect of premorbid hypertension control on outcome of patients with aneurysmal SAH. METHODS: We retrospectively reviewed the clinical data of patients with intracranial aneurysms admitted to our institution from February 2012 to December 2017...
October 12, 2018: Acta Neurochirurgica
Divya Garg, Christopher Naugler, Vishal Bhella, Fahmida Yeasmin
OBJECTIVE: To determine the positive predictive value (PPV) of a single random abnormal urine albumin-to-creatinine ratio (ACR) compared with repeat test results in patients with type 2 diabetes to diagnose chronic kidney disease (CKD). DESIGN: Retrospective, longitudinal secondary data analysis using Calgary Laboratory Services data. SETTING: Calgary, Alta. PARTICIPANTS: Patients aged 21 and older with a new diagnosis of diabetes in the study period from January 2008 to December 2015 and with a first abnormal urine ACR followed by another ACR test completed within 120 days...
October 2018: Canadian Family Physician Médecin de Famille Canadien
Maria Jose Soler, Montserrat Batlle, Marta Riera, Begoña Campos, José Tomás Ortiz-Perez, Lidia Anguiano, Heleia Roca-Ho, Marta Farrero, Lluis Mont, Julio Pascual, Felix Perez-Villa
OBJECTIVES: The authors sought to evaluate cardiac activity of angiotensin-converting enzyme (ACE) and ACE2 after heart transplantation (HT) and its relation with acute rejection (AR) and chronic allograft vasculopathy (CAV). BACKGROUND: The renin-angiotensin system is altered in heart failure and HT. However, ACE and ACE2 activities in post-HT acute and chronic rejection have not been previously studied. METHODS: HT patients (n = 45) were included when appropriate serial endomyocardial biopsies (EMB) and coronary angiography were available for analysis...
October 3, 2018: International Journal of Cardiology
Maciej Zdun, Ryszard Jabłoński, Dariusz Dębiński, Hieronim Frąckowiak
This article presents the results of analysis of the arterial vascular region of the Eurasian elk, which is a representative of the Cervidae family. The study was conducted on 39 Eurasian elks. The head arteries of 25 animals were filled with LBS 3040 synthetic latex. The head arteries of the other 14 Eurasian elks were filled with an acetone solution of stained chlorinated polyvinyl chloride and macerated. The arterial circle of the Eurasian elk's brain is composed of bilateral rostral cerebral arteries and caudal communicating arteries...
October 12, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Krzysztof Łukawski, Grzegorz Raszewski, Stanisław J Czuczwar
It has been demonstrated that certain angiotensin-converting enzyme (ACE) inhibitors and angiotensin AT1 receptor antagonists can possess anticonvulsant activity. The purpose of the current study was to examine the effect of aliskiren, a direct renin inhibitor and a novel antihypertensive drug, against pentylenetetrazole (PTZ)-induced clonic seizures in mice and on the protective activity of conventional antiepileptic drugs (AEDs) in this seizure model. Effects of aliskiren on the PTZ threshold and the protective efficacy of AEDs such as clonazepam (CLO), phenobarbital (PB), valproate (VPA) and ethosuximide (ETX) in the PTZ test, were evaluated in adult Swiss mice...
October 12, 2018: Fundamental & Clinical Pharmacology
Sahrai Saeed, Eva Gerdts
Hypertension is highly prevalent in aortic stenosis (AS) patients as the prevalence of both disorders increases with age. Hypertension and associated stiffening of the large arteries increase afterload and thereby influence both the transvalvular flow and the remodelling of the aortic root and the left ventricle during AS progression. Area covered: The present review gives an overview on complications of hypertension in AS, how these can be diagnosed, and potentially may be managed. Expert commentary: Hypertension-mediated cardiovascular damage in AS is associated with increased morbidity and a 2-fold higher mortality even in asymptomatic patients, and also limits the symptomatic and survival benefit from valve replacement...
October 12, 2018: Expert Review of Cardiovascular Therapy
Mo-Li Zhu, Rui-Li Sun, He-Yun Zhang, Fan-Rong Zhao, Guo-Pin Pan, Chong Zhang, Ping Song, Peng Li, Jian Xu, Shuangxi Wang, Ya-Ling Yin
BACKGROUNDS AND AIMS: Increased arterial stiffness may increase cardiovascular morbidity and mortality. Angiotensin II type 1 receptor blockers (ARBs) are potentially useful in controlling the central blood pressure and arterial stiffness in mild to moderate essential hypertension, while the effects of ARBs in aged patients with essential hypertension are not entirely investigated. METHODS: The carotid-femoral arterial pulse wave velocity (PWV) was measured in aged patients with essential hypertension...
October 12, 2018: Clinical and Experimental Hypertension: CHE
Mario Bo, Maddalena Gibello, Enrico Brunetti, Edoardo Boietti, Matteo Sappa, Yolanda Falcone, Maria Luigia Aurucci, Marina Iacovino, Gianfranco Fonte, Giorgetta Cappa
AIM: To evaluate the prevalence and predictors of potentially inappropriate medications (PIM) and potential prescribing omissions (PPO) in hospital-discharged older patients, according to the recently updated Screening Tool of Older People's Prescriptions and Screening Tool to Alert to Right Treatment version 2 criteria. METHODS: This was a multicenter prospective observational study of patients aged ≥65 years consecutively discharged from geriatric and internal medicine wards...
October 11, 2018: Geriatrics & Gerontology International
Li-Chuan Tan, Wen-Jie Yang, Wei-Ping Fu, Ping Su, Jing-Kui Shu, Lu-Ming Dai
Background: Heterogeneity of COPD results in different therapeutic effects for different patients receiving the same treatment. COPD patients need to be individually treated according to their own characteristics. The purpose of this study was to explore the differences in different CT phenotypic COPD by molecular metabolites through the use of metabolomics. Methods: According to the characteristics of CT imaging, 42 COPD patients were grouped into phenotype E (n=20) or phenotype M (n=24)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Jessica McHugh
No abstract text is available yet for this article.
October 11, 2018: Nature Reviews. Rheumatology
Doreen Muth, Victor Max Corman, Hanna Roth, Tabea Binger, Ronald Dijkman, Lina Theresa Gottula, Florian Gloza-Rausch, Andrea Balboni, Mara Battilani, Danijela Rihtarič, Ivan Toplak, Ramón Seage Ameneiros, Alexander Pfeifer, Volker Thiel, Jan Felix Drexler, Marcel Alexander Müller, Christian Drosten
A 29 nucleotide deletion in open reading frame 8 (ORF8) is the most obvious genetic change in severe acute respiratory syndrome coronavirus (SARS-CoV) during its emergence in humans. In spite of intense study, it remains unclear whether the deletion actually reflects adaptation to humans. Here we engineered full, partially deleted (-29 nt), and fully deleted ORF8 into a SARS-CoV infectious cDNA clone, strain Frankfurt-1. Replication of the resulting viruses was compared in primate cell cultures as well as Rhinolophus bat cells made permissive for SARS-CoV replication by lentiviral transduction of the human angiotensin-converting enzyme 2 receptor...
October 11, 2018: Scientific Reports
Marta Gładysz, Małgorzata Król, Patryk Własiuk, Michał Piwowar, Grzegorz Zadora, Paweł Kościelniak
In this study, the effective and robust semi-destructive ultrasound assisted extraction (UAE) method followed by gas chromatography coupled to mass spectrometry (GC-MS) method used for analysis of red lipsticks samples was developed, optimized and evaluated. 43 red lipsticks of a very similar hue representing of 21 different manufacturers were investigated. The red lipsticks (approximately 0.05 mg) were applied on a disc (of ø 2 mm) placed on specially designed stand printed with a 3D printer. In order to optimize the main factors affecting extraction process, Doehlert experimental design with response surface methodology was applied...
October 3, 2018: Journal of Chromatography. A
Karen Pitura, Susan D Arntfield
Seed coats of coloured dry beans contain biologically active compounds. Flavonol glycosides were identified from acetone extracts of seed coats of black beans, pinto beans, and red kidney beans and evaluated for antioxidant activity. High Performance Liquid Chromatography - Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging capacity were used to measure flavonols and antioxidant capacity, respectively. The main flavonol glycosides in black beans were the 3-O-glycosides of kaempferol, quercetin and myricetin; pinto beans contained kaempferol 3-O-glycosides, while red kidney beans contained quercetin 3-O-glycoside and quercetin 3-O-rutinoside (rutin)...
January 30, 2019: Food Chemistry
Kevin Albert Noronha Matos, Danielle Praia Lima, Anna Paula Pereira Barbosa, Adriana Zerlotti Mercadante, Renan Campos Chisté
Tucumã (Astrocaryum vulgare) and peach palm (Bactris gasipaes) are Amazonian fruits with high potential to be used as source of carotenoids due to the remarkable yellow-orange colour of their pulp and peel. In this study, for the first time, both the extraction of carotenoids from the peel of tucumã and peach palm fruits and their carotenoid profile were investigated. The carotenoid contents of the peel of both fruits were higher than those found in the pulp. The highest yield of carotenoids from both fruit peels were obtained at the solid-liquid ratio of 1:7 (w/v), 80 min of shaking and by adding 30% of ethyl acetate in acetone, being β-carotene the major carotenoid (7...
January 30, 2019: Food Chemistry
Andrew S Elder, John N Coupland, Ryan J Elias
Naturally derived antioxidants are in high demand as the food industry strives to meet consumer preferences for non-synthetic additives. Alkylresorcinols (ARs) represent a novel class of natural antioxidants that can be derived from a natural waste stream (bran) and have the potential to inhibit lipid peroxidation given their phenolic structure. The antioxidant activity of rye bran extract containing ARs was investigated in an oil-in-water emulsion and was found to inhibit lipid oxidation reactions. The concentration of ARs in the continuous phase of emulsions was measured to understand partitioning behavior, as this is known to impact antioxidant activity...
January 30, 2019: Food Chemistry
Gary Klase, Seungjun Lee, Song Liang, Jinnam Kim, Young-Gun Zo, Jiyoung Lee
Aquaculture, the production of farm-raised fish, is a major industry that employs and feeds millions of individuals across the globe, but which may also be a nexus of emerging public health threats. This study examined potential health risks associated with integrated aquaculture operations by with One Health approach using a suite of tools to study water contamination sources, pathogens, antibiotic resistant bacteria, and bacterial community in the water from fishponds. Water samples from 27 fishponds across 9 villages were collected in Jiangmen City, China...
February 1, 2019: Science of the Total Environment
Myung Hwangbo, Everett Caleb Claycomb, Yina Liu, Theodore E G Alivio, Sarbajit Banerjee, Kung-Hui Chu
Microbial and emerging chemical contaminants are unwanted constituents in reclaimed wastewater, due to the health concerns of using the water for agricultural irrigation, aquifer recharges, and potable water. Removal of these contaminants is required but it is currently challenging, given that there is no simple treatment technology to effectively remove the mixture of these contaminants. This study examined the effectiveness of ZnO-assisted photocatalytic degradation of several constituents, including 1,4-dioxane, trihalomethanes (THMs), triclosan (TCS), triclocarban (TCC), antibiotic resistant bacteria (ARB) and antibiotic resistant genes (ARGs), under low intensity of UV exposure...
February 1, 2019: Science of the Total Environment
Jaime Nivala, Stefanie Kahl, Johannes Boog, Manfred van Afferden, Thorsten Reemtsma, Roland A Müller
Six pilot-scale treatment wetlands treating municipal wastewater were monitored for classical wastewater parameters and selected Emerging Organic Compounds (EOCs): caffeine (CAF), ibuprofen (IBU), naproxen (NPX), benzotriazole (BTZ), diclofenac (DCL), acesulfame (ACE) and carbamazepine (CBZ) on a weekly basis over the course of one year. Treatment efficacy of the wetland systems was compared to that of a municipal wastewater treatment plant adjacent to the research site (activated sludge technology). The aerated wetlands VAp and HAp, and the two-stage vertical flow system VGp + VSp showed the highest treatment efficacy (>70% removal on a mass basis) and comparable treatment efficacy to the conventional WWTP for removal of CAF, IBU, NPX, BTZ, and DCL...
February 1, 2019: Science of the Total Environment
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