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A Fortini, V Verdiani, G Panigada, C Angotti, L Masotti
BACKGROUND: Guidelines recommend triple therapy (TT) with ACE inhibitors or ARBs, beta-blockers and mineralcorticoid receptor antagonists in symptomatic heart failure patients with ejection fraction <35 % (HFrEF). Nevertheless, many patients remain untreated. This study was aimed to evaluate the use of TT in HFrEF patients discharged from internal medicine wards of Tuscany, Italy. METHODS AND RESULTS: We analyzed the database of a multicenter observational study which included 770 patients consecutively hospitalized for HF in 32out of 36 Internal Medicine Units of Tuscany, Italy...
November 2018: La Clinica Terapeutica
Caroline A McHutchison, Vera Cvoro, Stephen Makin, Francesca M Chappell, Kirsten Shuler, Joanna M Wardlaw
OBJECTIVE: Many studies examining stroke outcomes focus on more severe strokes or have short follow-up periods, so the long-term outcomes post-minor ischaemic stroke are unclear. METHODS: We recruited participants from inpatient and outpatient services with a lacunar or minor cortical ischaemic stroke (National Institutes of Health Stroke Scale score <8) and assessed current and premorbid cognitive functioning (Addenbrooke's Cognitive Examination-Revised (ACE-R), National Adult Reading Test (NART)), physical functioning (Timed Get Up and Go (TUG), 9-Hole Peg Test (9HPT)), dependency (modified Rankin Scale (mRS)), depression (Beck's Depression Inventory) in-person and remotely (Stroke Impact Scale)...
December 15, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Nisha Sharma, Hans-Joachim Anders, Anil Bhanudas Gaikwad
Besides assisting the maintenance of blood pressure and sodium homeostasis, the renin-angiotensin system (RAS) plays a pivotal role in pathogenesis of acute kidney injury (AKI). The RAS is equipped with two arms i) the pressor arm composed of Angiotensin II (Ang II)/Angiotensin converting enzyme (ACE)/Angiotensin II type 1 receptor (AT1R) also called conventional RAS, and ii) the depressor arm consisting of Angiotensin (1-7) (Ang 1-7)/Angiotensin converting enzyme 2 (ACE2)/MasR known as non-conventional RAS...
December 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mauricio Baca, Mark Newberry
BACKGROUND: Cardiac amyloidosis is an underdiagnosed cause of restrictive cardiomyopathy resulting from the infiltration of the myocardium by amyloid proteins. CASE REPORT: We report the case of an 83-year-old woman who presented with increasing dyspnea and lower-extremity swelling. She reported a medical history of unspecified heart failure. Evaluation in the Emergency Department (ED) revealed evidence of heart failure on physical examination, low-voltage electrocardiogram, chest x-ray study with mild pulmonary edema, and laboratory evaluation with elevated brain natriuretic peptide and troponin...
December 12, 2018: Journal of Emergency Medicine
Qiuhong Rao, Zhenwen Qiu, Deen Huang, Tiejun Lu, Zhenyu Jason Zhang, Dandong Luo, Piaopiao Pan, Lei Zhang, Yingyan Liu, Shixia Guan, Qingguo Li
The ability to increase the bioavailability and dissolution of poorly soluble hydrophobic drugs has been a major challenge for pharmaceutical development. This study shows that the dissolution rate, apparent solubility and oral bioavailability of tadalafil (Td) can be improved by nano-sized amorphous particles prepared by using antisolvent precipitation. Acetone and an acetone-water solution (v:v, 9:1) were selected as solvents, with deionized water as the antisolvent. The antisolvent precipitation process was conducted at a constant drug concentration of 10 mg/mL, at temperatures of 5, 10 and 15 °C and at volume ratios of antisolvent to solvent (AS/S) of 5, 8 and 10...
December 12, 2018: European Journal of Pharmaceutical Sciences
JaiPrakash Agarwal, Deepanjali Adulkar, Monali Swain, Santam Chakraborty, Tejpal Gupta, Ashwini Budrukkar, Sarbani Ghosh-Laskar, Vedang Murthy
BACKGROUND: High prevalence of comorbidity in head and neck squamous cell carcinoma (HNSCC) often lead to suboptimal treatment. The presence study aims to evaluate the presence of comorbidity, its impact on therapeutic decision making, treatment compliance, and overall survival in HNSCC. METHODS: Five hundred eighteen patients with nonmetastatic HNSCC, elder than 18 years of age, without any prior history of cancer or anticancer treatment in the last 5 years were evaluated using Adult Comorbidity Evaluation 27 (ACE 27) index...
December 15, 2018: Head & Neck
Laura van Duin, Floor Bevaart, Josjan Zijlmans, Marie-Jolette A Luijks, Theo A H Doreleijers, André I Wierdsma, Albertine J Oldehinkel, Reshmi Marhe, Arne Popma
Adverse childhood experiences (ACEs) are associated with severe problems later in life. This study examines how eleven types of ACEs and mental health care use history are related to current psychological dysfunction among multi-problem young adults. A sample of 643 multi-problem young adult men (age 18-27) gave informed consent for us to collect retrospective regional psychiatric case register data and filled out questionnaires. ACEs were highly prevalent (mean 3.6, SD 2.0). Logistic regression analysis showed that compared with participants who experienced other ACEs, participants who experienced psychological problems in their family and grew up in a single-parent family were more likely to have used mental health care, and physically abused participants were less likely to have used mental health care...
December 14, 2018: European Child & Adolescent Psychiatry
Nadine Mirza, Maria Panagioti, Waquas Waheed
OBJECTIVES: Our research determined whether the Addenbrooke's Cognitive Examination Version III (ACE-III) Urdu eliminated cultural bias through a qualitative assessment of its understanding and acceptability within the British Urdu-speaking population, employing cognitive interviews. METHOD: We aimed to recruit 25 participants fluent in speaking and writing Urdu, over the age of 60 years, able to give informed consent and who did not have a history of cognitive impairment...
December 14, 2018: BMJ Open
Nguyen Dinh Thanh, Do Son Hai, Nguyen Thi Thu Ha, Do Tien Tung, Cao Thi Le, Hoang Thi Kim Van, Vu Ngoc Toan, Duong Ngoc Toan, Le Hai Dang
Some heterocycles, namely 2-amino-4H-pyran-3-carbonitriles, were synthesized in a three-component reaction from substituted benzaldehydes, malononitrile, and ethyl acetoacetate. These heterocycles have been converted subsequently into 4H-pyrano[2,3-d]pyrimidine ring by ring-closing reaction with acetic anhydride in the presence of the concentrated sulfuric acid as catalyst. The successive alkylation reaction of lactam NH bond on pyrimidine-4-one ring was carried out using propargylic bromide in dry acetone in the presence of anhydrous potassium carbonate...
December 6, 2018: Bioorganic & Medicinal Chemistry Letters
J Tromp, W Ouwerkerk, B G Demissei, S D Anker, J G Cleland, K Dickstein, G Filippatos, P van der Harst, H L Hillege, C C Lang, M Metra, L L Ng, P Ponikowski, N J Samani, D J van Veldhuisen, F Zannad, A H Zwinderman, A A Voors, P van der Meer
Aims: We sought to determine subtypes of patients with heart failure (HF) with a distinct clinical profile and treatment response, using a wide range of biomarkers from various pathophysiological domains. Methods and results: We performed unsupervised cluster analysis using 92 established cardiovascular biomarkers to identify mutually exclusive subgroups (endotypes) of 1802 patients with HF and reduced ejection fraction (HFrEF) from the BIOSTAT-CHF project. We validated our findings in an independent cohort of 813 patients...
December 13, 2018: European Heart Journal
Sana El Mhamdi, Andrine Lemieux, Manel Ben Fredj, Ines Bouanene, Arwa Ben Salah, Hela Abroug, Kamel Ben Salem, Mustafa al'Absi
Early life adversities (ELAs) are shown as significant risk factors for chronic health conditions (CHCs). ELAs include multiple types of abuse such as the social abuse (peer, community, and collective violence). The purpose is to describe the relationship between childhood social abuse and chronic conditions in adulthood among a sample of adults in Tunisia and to investigate the role of obesity and tobacco use as mediators of this association. A cross-sectional study was conducted in Tunisia, from January to June 2016 using the Arabic Adverse Childhood Experiences International Questionnaire (ACE-IQ)...
December 13, 2018: Translational Behavioral Medicine
Maximilian Hubert Schreck, Merle I S Röhr, Timothy Clark, Vladimir Stepanenko, Frank Würthner, Christoph Lambert
We describe the aggregate formation and optical properties of a star-shaped hexaarylbenzene with six squaraine chromophores (= hexasquarainyl benzene). Comprehensive concentration-dependent studies in acetone/CHCl3 mixtures reveal a strong propensity to form discrete dimeric aggregates with a high binding constant in excess of 1 E6 M-1. In this context, a large hypsochromic shift of almost 2 700 cm-1 was found in the absorption spectrum, indicating H-type exciton coupling. The aggregate band is characterized by a very small band width of only 560 cm-1, probably caused by exchange narrowing...
December 14, 2018: Chemistry: a European Journal
Diane da Costa Miranda, Sonia Maria Dozzi Brucki, Mônica Sanches Yassuda
The Mini-Addenbrooke's Cognitive Examination (M-ACE) is a brief cognitive screening test that evaluates four main cognitive domains (orientation, memory, language and visuospatial function) with a maximum score of 30 points and administration time of five minutes. Objective: To assess the performance of healthy elderly, MCI patients and mild AD patients using the Brazilian version of the M-ACE. Methods: The test was applied to a group of 36 Mild Cognitive Impairment (MCI), 23 mild Alzheimer's Disease (AD) and 25 cognitive healthy elderly...
October 2018: Dementia & Neuropsychologia
A S Antonov, A F Pozharskii, P M Tolstoy, A Filarowski, O V Khoroshilova
The structure and protonation behaviour of four ortho -arylketimines of 1,8-bis(dimethylamonio)naphthalene with a different number of methoxy groups in an aromatic substituent were investigated in solution by NMR (acetone, DMSO, MeCN), in solid state by X-ray analysis and in the gas phase by DFT calculations. Both mono- and diprotonated species were considered. It has been shown that E -isomers of neutral imines can be stabilised by an intramolecular C=N-H···OMe hydrogen bond with a neighbouring methoxy group...
2018: Beilstein Journal of Organic Chemistry
Jesús Martínez-Sámano, Adriana Torres-Montes de Oca, Oscar Ivan Luqueño-Bocardo, Patricia V Torres-Durán, Marco A Juárez-Oropeza
(1) Background: Spirulina ( Arthrospira ) maxima has shown beneficial effects such as being anti-dyslipidemic, antiviral, antioxidant and antihypertensive. However, there are few and limited clinical studies. (2) Methods: a prospective, randomized, parallel pilot study of 4.5 g administration of Spirulina maxima or placebo for 12 weeks in 16 patients with systemic arterial hypertension (SAH) undergoing treatment with angiotensin-converting enzyme (ACE) inhibitors was performed to assess the effects on endothelial damage and oxidative stress indicators...
December 8, 2018: Marine Drugs
Gioele Capillo, Serena Savoca, Rosaria Costa, Marilena Sanfilippo, Carmen Rizzo, Angelina Lo Giudice, Ambrogina Albergamo, Rossana Rando, Giovanni Bartolomeo, Nunziacarla Spanò, Caterina Faggio
Enormous marine biodiversity offers an endless reservoir of chemicals for many applications. In this scenario, the extraction of seaweeds represents an interesting source of compounds displaying antimicrobial activity. In particular, among the different red algae, Gracilaria gracilis plays an important role due to the presence of important bioactives in its composition. In spite of these features, an efficient culture system is still absent. In the present study, a novel algal culture method was developed and compared to another more common cultural practice, widely reported in literature...
December 7, 2018: Marine Drugs
Gang Liao, Wu Yao, Junqing Zuo
A zeolite/TiO₂ composite (ZTC) was applied to prepare a high-quality photocatalytic cement-based material (PCM). The acetone degradation experiment and micro measurements including XRD(X-Ray Diffractometer), SEM-EDS(Scanning Electron Microscope-Energy Dispersive Spectrometer), BET(BET Specific Surface Area Tester), FTIR(Fourier Transform Infrared Spectrometer) were conducted to characterize the photocatalytic efficiency and physicochemical properties of PCM, respectively. Results show that TiO₂ particles disperse on the surface of a PCM homogeneously and provide abundant active sites for photocatalytic reactions...
December 7, 2018: Materials
Tao Li, Qili Li, Weiguo Wu, Yong Li, De-Xing Hou, Hua Xu, Baodong Zheng, Shaoxiao Zeng, Yang Shan, Xiangyang Lu, Fangming Deng, Si Qin
Lotus seed is well known as traditional food and medicine, but its skin is usually discarded. Recent studies have shown that lotus seed skin contains a high concentration of proanthocyanidins that have multi-functions, such as antioxidation, anti-inflammation, and anti-cancer effects. In the present study, we aimed to isolate and purify the proanthocyanidins from lotus seed skin by acetone extraction and rotary evaporation, identify their chemical structures by HPLC-MS-MS and NMR, and further investigate the antioxidant properties of the extract purified by macroporous resin (PMR) from lotus seed skin both in vitro and in vivo...
December 13, 2018: Acta Biochimica et Biophysica Sinica
A Fan, G K Chuah, Stephan Jaenicke
A critical step in the synthesis of the hydroxypyrrolidines, 1,4-dideoxy-1,4-imino-l-lyxitol and 1,4-dideoxy-1,4-imino-d-lyxitol, from the corresponding d-sugars is the synthesis of O-methyl 2,3-O-isopropylidenepentofuranoses. Instead of applying homogeneous catalysis process with conventional inorganic acid catalysts like HCl and HClO4 , it was found that heterogeneous catalysis using zeolites could be used for the one-pot synthesis of O-methyl 2,3-O-isopropylidenepentofuranoses directly from d-sugars, MeOH and acetone at mild condition...
December 4, 2018: Carbohydrate Research
Meng Dong, Yong Dong Liu, Rugang Zhong
N-nitrosodimethylamine (NDMA) as the most frequently detected disinfection by-product has aroused widespread concern due to its unusually high carcinogenicity, however, there is still limited understanding of its formation mechanisms. In this study, the formation mechanisms of NDMA from some typical hydrazines and hydrazones with high NDMA conversion yields (60%∼90%) during ozonation, i.e., unsymmetrical dimethylhydrazine (UDMH), 1-formyl-2,2-dimethylhydrazine (FDMH), formaldehyde dimethylhydrazone (FDH) and acetone dimethylhydrazone (ADMH), were investigated by using DFT method with the M05 functional...
December 4, 2018: Journal of Hazardous Materials
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