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https://www.readbyqxmd.com/read/30118798/cardiac-resynchronization-therapy-pacemakers-versus-defibrillators-in-older-non-ischemic-cardiomyopathy-patients
#1
Yanting Wang, Michael S Sharbaugh, Andrew D Althouse, Suresh Mulukutla, Samir Saba
INTRODUCTION: With the recent publication of the negative DANISH trial, the mortality benefit of the implantable cardioverter-defibrillator (ICD) has been put in question in patients with non-ischemic cardiomyopathy (NICM). Because a majority of patients in DANISH receive cardiac resynchronization therapy (CRT) devices, we investigated in the present study the survival of recipients of CRT pacemakers (CRT-P) versus CRT ICDs (CRT-D) in a cohort of older (≥75 years) NICM patients at our institution...
August 14, 2018: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/30118539/distinguishing-characteristics-of-robotic-writing
#2
Aurora Dumitra, Anna Guzowski, Alynka Jean, Melvin Shaw, Grace Warmbier, Patricia Zippo
Advances in robotic handwriting technology create new challenges for forensic document examiners. In the past, devices such as the autopen were used to replicate signatures of government officials and corporate companies. In today's technology, companies such as Bond utilize robots to create written documents, which mimic natural patterns of handwriting. They generate customizable written samples by simulating pen movements and letter formations. Four forensic document examiners were given various reproduced questioned documents and utilized a modified ACE-V (analysis, comparison, evaluation, verification) methodology to determine their genuineness...
August 17, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/30117239/ryoji-noyori-aces-award-for-martin-g-banwell-liebig-memorial-medal-for-wolfgang-schnick-izatt-christensen-award-for-philip-a-gale-cram-lehn-pedersen-prize-for-rafal-klajn
#3
(no author information available yet)
No abstract text is available yet for this article.
August 17, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30116589/crystal-structure-of-tetra-kis-1-1-1-5-5-5-hexa-fluoro-acetyl-acetonato-hafnium-iv
#4
W Franklin Schwandt, Toby J Woods, Gregory S Girolami
The crystal structure of the title compound, [Hf(C5 HF6 O2 )4 ], has been determined. The asymmetric unit contains two Hf(hfac)4 mol-ecules (hfac = 1,1,1,5,5,5-hexa-fluoro-acetyl-acetonate); both are located on general positions and have identical structures apart from the disorder involving three CF3 groups in one of the two mol-ecules. The mol-ecules of Hf(hfac)4 are arranged in layers that are parallel to the ab plane, and the coordination geometry of each hafnium(IV) center is a distorted square anti-prism...
August 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/30115580/prevalence-and-predictors-of-liver-fibrosis-evaluated-by-vibration-controlled-transient-elastography-in-type-1-gaucher-disease
#5
Fabio Nascimbeni, Elena Cassinerio, Annalisa Dalla Salda, Irene Motta, Serena Bursi, Salvatore Donatiello, Vincenzo Spina, Maria Domenica Cappellini, Francesca Carubbi
BACKGROUND & AIMS: Long-term liver-related complications of Gaucher disease (GD) include cirrhosis, portal hypertension and hepatocellular carcinoma. Although liver fibrosis is the main determinant of adverse liver-related clinical outcomes, it has rarely been evaluated in previously published cohorts of GD patients. We aimed at: assessing the prevalence of significant liver fibrosis in a cohort of patients with type 1 GD; identifying its predictors among GD-related variables, enzyme replacement therapy (ERT) and metabolic features...
August 11, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/30114475/the-left-central-nucleus-of-the-amygdala-contributes-to-mechanical-allodynia-and-hyperalgesia-following-right-sided-peripheral-nerve-injury
#6
Andrew H Cooper, Jennifer J Brightwell, Naomi S Hedden, Bradley K Taylor
The left and right central nucleus of the amygdala (CeA) exert asymmetric pronociceptive functions. In the setting of a transient noxious stimulus or persistent inflammatory pain, neuronal activity increases in the right but not left CeA, regardless of side of injury. Much less is known regarding this lateralization with respect to the behavioral manifestations of persistent neuropathic pain. To address this question, we conducted spared nerve injury (SNI) to the left or right hindlimb and then inactivated the left and/or right CeA with local microinjection of lidocaine...
August 13, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/30114455/angiotensin-converting-enzyme-and-subclinical-atherosclerosis-in-psoriasis-is-there-any-association-a-case-control-study
#7
Fahimeh Abdollahimajd, Nasim Niknezhad, Hamid Reza Haghighatkhah, Nastaran Namazi, Nakisa Niknejad, Atefeh Talebi
No abstract text is available yet for this article.
August 13, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/30113975/angiotensin-converting-enzyme-inhibitors-and-angiotensin-ii-receptor-blockers-before-elective-noncardiac-surgery-an-ongoing-dilemma
#8
Sudarshan Setty, Daniela Orza, Kumar G Belani
No abstract text is available yet for this article.
September 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30113970/take-it-or-leave-it-a-meta-analysis-of-perioperative-ace-inhibitors-and-arbs
#9
Naveen Nathan
No abstract text is available yet for this article.
September 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30113826/gas-particle-partitioning-constants-k-p-of-nicotine-selected-toxicants-and-flavor-chemicals-in-solutions-of-50-50-propylene-glycol-glycerol-as-used-in-electronic-cigarettes
#10
James F Pankow, Kilsun Kim, Wentai Luo, Kevin J McWhirter
For an electronic cigarette (e-cigarette) aerosol with known total particulate matter concentration (TPM, μg/m3 ), predictions of the fractions of some compound i in the gas and particle phases ( fg, i and fp, i ) at equilibrium can be made based on Kp, i (m3 /μg), the compound-dependent gas/particle partitioning equilibrium constant. fg, i and fp, i affect the modes and locations of deposition in the respiratory tract. Kp, i depends inversely on: 1) the pure-compound liquid vapor pressure ( po L, i ); 2) mole-fraction activity coefficient (ζ i ) in the absorbing liquid; and 3) mean molecular weight of the absorbing liquid (MW)...
August 16, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/30113825/kinetic-study-of-chiral-intermolecular-interaction-by-moment-analysis-based-on-affinity-capillary-electrophoresis
#11
Nozomu Suzuki, Mariko Kinoshita, Kanji Miyabe
Capillary electrophoresis is a method for analyzing intermolecular interactions that does not require immobilization of mole-cules to substrate or introduction of luminescent moiety. Recently, an advanced method, moment analysis based on affinity capillary electrophoresis (MA-ACE), was developed. This method can determine not only the equilibrium constant, but also the rate constants of an intermolecular interaction. Through MA-ACE, it became possible to theoretically predict an increase in the variance of an eluted peak caused by intermolecular interaction...
August 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30113526/diabetic-patients-with-essential-hypertension-treated-with-amlodipine-blood-pressure-and-arterial-stiffness-effects-of-canagliflozin-or-perindopril
#12
Agustin J Ramirez, Maria J Sanchez, Ramiro A Sanchez
INTRODUCTION: Hypertension control reduces cardiovascular and renal risks in type 2 diabetes. Sodium-glucose cotransporter-2 inhibitors prevent renal glucose reabsorption and decrease glucose plasma levels, blood pressure (BP) and weight reduction. Treatment of hypertension and sodium-glucose cotransporter-2 are able to improve arterial stiffness. AIMS: To evaluate, in patients with type 2 diabetes and hypertension, the effects of 6 months treatment with canagliflozin, or perindopril, an angiotensin converting enzyme inhibitor, on central BP and carotid-femoral pulse wave velocity (cfPWV)...
August 14, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/30113034/-enalaprilat-inhibits-zinc-dependent-oligomerization-of-metal-binding-domain-of-amyloid-beta-isoforms-and-protects-human-neuroblastoma-cells-from-toxic-action-of-these-isoforms
#13
S A Kozin, V I Polshakov, Y V Mezentsev, A S Ivanov, S S Zhokhov, M M Yurinskaya, M G Vinokurov, A A Makarov, V A Mitkevich
Intact amyloid-β peptides (Aβ) may undergo prion-like aggregation when they interact with chemically or structurally modified variants of Aβ present in extracellular pathohistological inclusions (amyloid plaques). This aggregation is regarded as one of the key molecular mechanisms of Alzheimer's disease (AD) pathogenesis. Zinc ions are involved in the pathological dimerization and oligomerization of natural Aβ isoforms, and zinc-induced oligomers can also initiate the pathological aggregation of Aβ. Based on the earlier found molecular mechanism of zinc-dependent oligomerization of Aβ, it has been suggested that the targeted inhibition of the 11EVHH14 site in one Aβ molecule from zinc-mediated interactions with the same site of another Aβ molecule can effectively inhibit the oligomerization and aggregation of Aβ...
July 2018: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/30112808/methanogenic-community-during-the-anaerobic-digestion-of-different-substrates-and-organic-loading-rates
#14
Dewang Kong, Keqiang Zhang, Junfeng Liang, Wenxuan Gao, Lianzhu Du
Three anaerobic reactors using pig manure (PM), maize straw (MS), and a mixture of the two as substrates were compared for archaeal community structure and diversity, and for methanogens response to increased organic loading rate (OLR, expressed in the mass of volatile solid (VS)). Methanogenic archaeal richness during codigestion of pig manure with maize straw (ACE: 2412) was greater than that during the others (ACE: 1225, 1467) at an OLR of 4 g L-1  day-1 , accompanied by high specific methane yield. Euryarchaeota and Crenarchaeota predominated during overall digestion of different substrates; with relative abundances of 63...
August 15, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/30112656/should-ace-inhibitors-and-arbs-be-used-in-combination-in-children
#15
Brian R Stotter, Michael A Ferguson
The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in a host of renal and cardiovascular functions. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), drugs that disrupt RAAS function, are effective in treating hypertension and offer other renoprotective effects independent of blood pressure (BP) reduction. As our understanding of RAAS physiology and the feedback mechanisms of ACE inhibition and angiotensin receptor blockade have improved, questions have been raised as to whether combination ACEI/ARB therapy is warranted in certain patients with incomplete angiotensin blockade on one agent...
August 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30112218/can-ace-i-be-a-silent-killer-while-normal-renal-functions-falsely-secure-us
#16
Ahmed Abdelaal Ahmed Mahmoud, Mark Campbell, Margarita Blajeva
The current case report represents a warning against serious hyperkalaemia and acidosis induced by ACE-I during surgical stress while normal renal function could deceive the attending anaesthetist. Arterial gas analysis for follow-up of haemoglobin loss accidentally discovered hyperkalaemia and acidosis. Glucose-insulin and furosemide successfully corrected hyperkalaemia after 25 minutes and acidosis after 3 hours. These complications could be explained by a deficient steroid stress response to surgery secondary to suppression by ACE-I...
2018: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/30112107/autophagy-dependent-apoptosis-is-triggered-by-a-semi-synthetic-6-gingerol-analogue-in-triple-negative-breast-cancer-cells
#17
Liany Luna-Dulcey, Rebeka Tomasin, Marina A Naves, James A da Silva, Marcia R Cominetti
Triple negative breast cancer (TNBC) is very aggressive and lacks specific therapeutic targets, having limited treatment options and poor prognosis. [6]-gingerol is the most abundant and studied compound in ginger, presenting diverse biological properties such as antitumor activity against several types of cancer, including breast cancer. In this study, we show that the semi-synthetic analogue SSi6, generated after chemical modification of the [6]-gingerol molecule, using acetone-2,4-dinitrophenylhydrazone (2,4-DNPH) reagent, enhanced selective cytotoxic effects on MDA-MB-231 cells...
July 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/30112041/naringenin-inhibits-n-g-nitro-l-arginine-methyl-ester-induced-hypertensive-left-ventricular-hypertrophy-by-decreasing-angiotensin-converting-enzyme-1-expression
#18
Yanxiang Gao, Zhizhi Wang, Yayun Zhang, Yuting Liu, Shanshan Wang, Weiliang Sun, Jing Guo, Changan Yu, Yong Wang, Wei Kong, Jingang Zheng
Naringenin (NGN) is a natural flavonoid that exerts antiinflammatory, antioxidant and cardioprotective effects. The present study investigated the effects of NGN on left ventricular hypertrophy in rats with NG -nitro-L-arginine methyl ester (L-NAME)-induced hypertension, and sought to determine the underlying mechanism of action. The rats received the following by gavage daily for 56 days: L-NAME (50 mg/kg/day) + NGN (100 mg/kg/day), L-NAME (50 mg/kg/day) + saline, or saline + saline. Blood pressure, heart rate and body weight were recorded...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30112012/adverse-childhood-experiences-health-related-quality-of-life-and-chronic-disease-risks-in-rural-areas-of-the-united-states
#19
Amy Chanlongbutra, Gopal K Singh, Curt D Mueller
Exposure to adverse childhood experiences (ACEs) is associated with increased odds of high-risk behaviors and adverse health outcomes. This study examined whether ACE exposure among individuals living in rural areas of the United States is associated with adult activity limitations, self-reported general poor health status, chronic diseases, and poor mental health. Data from the 2011 and 2012 Behavioral Risk Factor Surveillance System (BRFSS) (N=79,810) from nine states were used to calculate the prevalence of ACEs in rural and urban areas...
2018: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/30111131/interplay-of-structure-and-diffusion-in-ternary-liquid-mixtures-of-benzene-acetone-varying-alcohols
#20
Gabriela Guevara-Carrion, Yuri Gaponenko, Aliaksandr Mialdun, Tatjana Janzen, Valentina Shevtsova, Jadran Vrabec
The Fick diffusion coefficient matrix of ternary mixtures containing benzene + acetone + three different alcohols, i.e., methanol, ethanol, and 2-propanol, is studied by molecular dynamics simulation and Taylor dispersion experiments. Aiming to identify common features of these mixtures, it is found that one of the main diffusion coefficients and the smaller eigenvalue do not depend on the type of alcohol along the studied composition path. Two mechanisms that are responsible for this invariant behavior are discussed in detail, i...
August 14, 2018: Journal of Chemical Physics
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