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Pulmonary hypertension and cancer

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https://www.readbyqxmd.com/read/29781402/life-expectancy-and-comorbidities-in-patients-with-hereditary-hemorrhagic-telangiectasia
#1
Freya Droege, Kruthika Thangavelu, Boris A Stuck, Andreas Stang, Stephan Lang, Urban Geisthoff
There are only a few published studies that demonstrate associations between life expectancy, severe comorbidities, and their complications in patients with hereditary hemorrhagic telangiectasia (HHT). Relatives of 73 deceased patients with suspected HHT completed a questionnaire about causes of death, and symptoms and comorbidities that the patients had developed. We compared the data for 55 cases where HHT had been clinically confirmed with the general population. Patients suffering from HHT lost, on average, 19 years (SD 11 years) of potential life compared to the general population...
May 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29763900/c-prosp-b-a-possible-biomarker-for-pulmonary-diseases
#2
Nicolas Kahn, Anne-Kathrin Rossler, Katrin Hornemann, Thomas Muley, Ekkehard Grünig, Werner Schmidt, Felix J F Herth, Michael Kreuter
BACKGROUND: Detection of surfactant proteins A and D (SP-A and SP-D) in the serum of patients with pulmonary diseases is thought to reflect an injury of the alveolar epithelial barrier and as such serve as a biomarker for these diseases. However, the data for SP-B are limited. OBJECTIVES: The aim of this feasibility study was to assess whether immature SP-B pre-proteins might have value as a possible biomarker for pulmonary diseases. METHODS: In serum samples from patients with different chronic lung diseases (interstitial lung diseases [ILDs], chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary hypertension, inflammation, patients on ventilator support; total n = 283), C-proSP-B was measured using an electrochemiluminescence immunoassay based on mouse monoclonal anti-C-proSP-B antibodies...
May 15, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29753296/mortality-specific-comorbidity-among-inpatients-with-epilepsy-a-preliminary-cross-sectional-study-in-west-china
#3
Yang Si, Xiaoqiang Xiao, Hongbin Sun
PURPOSE: The purpose of this study was to investigate the current condition of mortality-specific comorbidity among hospitalized patients with epilepsy (PWE). METHODS: The discharge abstract records of PWE from over 730,000 admissions were extracted from the hospital medical database. Fourteen mortality-related comorbidities from an epilepsy-specific index (ESI) were selected for the present assessment. The hospital-based prevalence of these comorbidities was estimated...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29753293/risk-assessment-of-in-hospital-mortality-of-patients-with-epilepsy-a-large-cohort-study
#4
Yang Si, Xiaoqiang Xiao, Shunju Xiang, Jing Liu, Qianning Mo, Hongbin Sun
PURPOSE: This study aimed to explore the mortality risks of hospitalized patients with epilepsy (PWE). METHODS: Our data source was extracted from discharge abstracts in a hospital medical database. Various clinical variables, including demographical characteristics, natural features of epilepsy, and comprehensive set of comorbidities, were screened to investigate the risk. Comorbidities were defined using a validated ICD-10-based classification. The distributions of comorbid conditions and demographics were presented...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29748016/lorlatinib-induced-pulmonary-arterial-hypertension
#5
Alexandre Chabrol, Marie Mayenga, Abdul Momen Hamid, Sylvie Friard, Hélène Salvator, Hélèe Doubre, Séverine Fraboulet, Anne-Cécile Metivier, Emilie Catherinot, Elisabeth Rivaud, Marie Camille Chaumais, David Montani, Louis Jean Couderc, Colas Tcherakian
We report here the first cases, to our knowledge, of pulmonary arterial hypertension induced by lorlatinib. It s the first time that a tyrosine kinase inhibitor for lung cancer is associated with pulmonary arteriel hypertension.
June 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29743944/repurposing-drugs-in-oncology-redo-selective-pde5-inhibitors-as-anti-cancer-agents
#6
Pan Pantziarka, Vidula Sukhatme, Sergio Crispino, Gauthier Bouche, Lydie Meheus, Vikas P Sukhatme
Selective phosphodiesterase 5 inhibitors, including sildenafil, tadalafil and vardenafil, are widely-used in the treatment of erectile dysfunction and pulmonary arterial hypertension. They are also well-known as examples of successful drug repurposing in that they were initially developed for angina and only later developed for erectile dysfunction. However, these drugs may also be effective cancer treatments. A range of evidentiary sources are assessed in this paper and the case made that there is pre-clinical and clinical evidence that these drugs may offer clinical benefit in a range of cancers...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29741696/long-term-cardiovascular-outcomes-among-endometrial-cancer-survivors-in-a-large-population-based-cohort-study
#7
Sean Soisson, Patricia A Ganz, David Gaffney, Kerry Rowe, John Snyder, Yuan Wan, Vikrant Deshmukh, Mike Newman, Alison Fraser, Ken Smith, Kimberly Herget, Heidi A Hanson, Yelena P Wu, Joseph Stanford, Ali Al-Sarray, Theresa L Werner, Veronica W Setiawan, Mia Hashibe
Background: Endometrial cancer is the second most common cancer among female cancer survivors in the United States. Cardiovascular disease is the leading cause of death among endometrial cancer survivors. Studies that examine long-term cardiovascular outcomes among endometrial cancer survivors are critical. Methods: Cohorts of 2648 endometrial cancer survivors diagnosed between 1997 and 2012 and 10 503 age-matched women from the general population were identified...
May 8, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29729133/impact-of-multiple-chronic-conditions-on-activity-limitations-among-older-mexican-american-care-recipients
#8
Diane M Collins, Brian Downer, Amit Kumar, Shilpa Krishnan, Chih-Ying Li, Kyriakos S Markides, Amol M Karmarkar
INTRODUCTION: Older Mexican Americans are living longer with multiple chronic conditions (MCCs). This has placed greater demands on caregivers to assist with basic activities of daily living (ADL) or instrumental activities of daily living (IADL). To understand the needs of older Mexican-American care recipients, we examined the impact of MCC on ADL and IADL limitations. METHODS: We analyzed data from 485 Mexican American care-receiving/caregiving dyads. Selected MCCs in the analysis were diabetes, hypertension, stroke, heart disease, arthritis, emphysema/chronic obstructive pulmonary disease, cognitive impairment, depression, and cancer...
May 3, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29708541/deep-vein-thrombosis-induced-by-stasis-in-mice-monitored-by-high-frequency-ultrasonography
#9
Ryan N Rys, Mark D Blostein, Catherine A Lemarié
Venous thrombosis is a common condition affecting 1 - 2% of the population, with an annual incidence of 1 in 500. Venous thrombosis can lead to death through pulmonary embolism or results in the post-thrombotic syndrome, characterized by chronic leg pain, swelling, and ulceration, or in chronic pulmonary hypertension resulting in significant chronic respiratory compromise. This is the most common cardiovascular disease after myocardial infarction and ischemic stroke and is a clinical challenge for all medical disciplines, as it can complicate the course of other disorders such as cancer, systemic disease, surgery, and major trauma...
April 13, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29706824/late-breast-cancer-recurrence-with-bone-marrow-metastases-and-acute-pulmonary-hypertension
#10
Dinesh Atwal, Jeanette M Ramos, Issam Makhoul
Bone marrow is one of the most common sites of metastasis from breast cancer. Micrometastases to the bone marrow usually evade the systemic therapies used for the treatment of cancer and eventually lead to relapse later in the course of the illness. We report here a unique case of parallel progression of these bone marrow metastases in a patient with breast cancer who had a relapse a few years after treatment of her primary breast cancer, and she presented with diffuse marrow involvement and pulmonary hypertension without any definitive metastases elsewhere...
April 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29700855/long-term-extra-pulmonary-comorbidities-after-lung-transplantation-in-cystic-fibrosis-update-of-specificities
#11
REVIEW
Sabine Jardel, Quitterie Reynaud, Isabelle Durieu
Lung transplantation (LT) is the standard therapeutic option for cystic fibrosis (CF) patients with end-stage lung disease. Both conditions lead to extra-respiratory complications, such as diabetes, renal insufficiency, bone disease, and cancer. The purpose of the present paper is to provide an update of the non-respiratory comorbidities following LT in adult patients with CF and their specificities regarding their multi-systemic underlying condition despite their younger age compared to other patients undergoing LT...
April 26, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29695372/comprehenotes-an-instrument-to-assess-patient-reading-comprehension-of-electronic-health-record-notes-development-and-validation
#12
John P Lalor, Hao Wu, Li Chen, Kathleen M Mazor, Hong Yu
BACKGROUND: Patient portals are widely adopted in the United States and allow millions of patients access to their electronic health records (EHRs), including their EHR clinical notes. A patient's ability to understand the information in the EHR is dependent on their overall health literacy. Although many tests of health literacy exist, none specifically focuses on EHR note comprehension. OBJECTIVE: The aim of this paper was to develop an instrument to assess patients' EHR note comprehension...
April 25, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29674000/angiotensin-ii-promotes-pulmonary-metastasis-of-melanoma-through-the-activation-of-adhesion-molecules-in-vascular-endothelial-cells
#13
Shin Ishikane, Hiroshi Hosoda, Takashi Nojiri, Takeshi Tokudome, Tetsuya Mizutani, Koichi Miura, Yoshiharu Akitake, Toru Kimura, Yoshitaka Imamichi, Shinya Kawabe, Yumiko Toyohira, Nobuyuki Yanagihara, Fumi Takahashi-Yanaga, Mikiya Miyazato, Kaoru Miyamoto, Kenji Kangawa
Hypertension is considered as one of the cancer progressive factors, and often found comorbidity in cancer patients. Renin-angiotensin system (RAS) plays an important role in the regulation of blood pressure, and angiotensin II (Ang II) is well known pressor peptide associated with RAS. Ang II has been reported to accelerate progression and metastasis of cancer cells. However, its precise mechanisms have not been fully understood. In this study, we sought to elucidate the mechanisms by which Ang II exacerbates hematogenous metastasis in mouse melanoma cells, focusing the adhesion pathway in vascular endothelial cells...
April 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29673080/systemic-sclerosis-and-malignancy
#14
Gokhan Sargin, Taskin Senturk, Songul Cildag
BACKGROUND: Systemic sclerosis (SSc) has increased risk of morbidity and mortality due to pulmonary fibrosis, pulmonary arterial hypertension, renal crisis, infections and malignancies. Chemical exposure, smoking and cytotoxic drugs increase the malignancy risk in rheumatic diseases including SSc. We aim to evaluate characteristics, identify risk factors and mortality in SSc patients with malignancies. METHODS: One hundred and fifty-three patients with SSc (24 male, 129 female, with mean age of 56...
April 19, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29650821/-continuation-of-axitinib-for-advanced-renal-cell-carcinoma-by-the-application-of-homecare-urology-a-case-report-and-literature-review
#15
Satoshi Yazawa, Yuji Kato, Jin Nakahara, Toshio Miyata, Mototsugu Oya
A 56-year-old man with advanced RCC and a past medical history of type 2 diabetes underwent a radical left nephrectomy following a histological diagnosis of papillary RCC, G2, INF b, pT3, V1 in 1999. In 2008, sorafenib was started to treat multiple pulmonary metastases of RCC. In 2011, sorafenib was switched to sunitinib when radiologic progression was observed. In 2014, sunitinib was switched to axitinib when further radiologic progression was observed. In 2015, the patient was referred to Yazawa clinic for homecare urology when hospital visits became difficult due to cancer pain and bilateral lower-extremity muscle weakness...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649782/balloon-pulmonary-angioplasty-in-a-patient-with-prostate-cancer-and-chronic-thromboembolic-pulmonary-hypertension
#16
Yolanda Bryce, Ernesto Santos
Chronic thromboembolic pulmonary hypertension (CTEPH) is a subtype of pulmonary hypertension characterized by a mean pulmonary artery pressure ≥25 mm Hg due to obstructive fibrotic thromboembolic material in the pulmonary arteries. Malignancy is a significant risk for developing CTEPH. The option for inoperable CTEPH is largely medical with variable outcomes. Balloon pulmonary angioplasty (BPA) is a promising option for inoperable patients given distal-type CTEPH, co-morbidities, or residual pulmonary hypertension after surgery...
April 6, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29601566/-disturbances-of-calcium-metabolism-and-vitamin-d-supplementation-in-sarcoidosis-two-way-street
#17
REVIEW
Anna Kempisty, Anna Lewandowska, Jan Kuś
The role of vitamin D in the human body is not limited only to the regulation of calcium metabolism and secondary to the impact on bones. Recent studies have shown the influence of vitamin D level on muscles, on the risk of cancer, diabetes, hypertension and pulmonary diseases, including granulomatous diseases. Sarcoidosis is a granulomatous disease of unknown etiology. Hypercalcemia in the course of the disease occurs in up to 10% of cases in the consequence of autonomous overproduction of 1,25-dihydroxyvitamin D by macrophages of sarcoid granulomas...
March 27, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29572812/the-risk-burden-and-management-of-non-communicable-diseases-in-cerebral-palsy-a-scoping-review
#18
REVIEW
Jennifer M Ryan, Elizabeth Allen, John Gormley, Edward A Hurvitz, Mark D Peterson
AIM: To examine the risk, burden, and management of non-communicable diseases (NCDs) among people with cerebral palsy (CP). METHOD: Databases (Ovid MEDLINE, Embase Ovid, CINAHL Plus) were systematically searched up to August 2017. Data on the prevalence of risk factors for, and the burden and management of, cardiovascular diseases, diabetes, cancers, and respiratory diseases were extracted. RESULTS: Thirty-six studies that examined the prevalence of risk factors among people with CP were identified...
March 24, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29563017/predictors-of-adverse-outcome-in-patients-with-myocardial-infarction-with-non-obstructive-coronary-artery-minoca-disease
#19
A M Nordenskjöld, T Baron, K M Eggers, T Jernberg, B Lindahl
BACKGROUND: Myocardial infarction (MI) with non-obstructive coronary arteries (MINOCAs) is an increasingly recognized entity. No previous study has evaluated predictors for new major adverse cardiacvascular events (MACEs) and death in patients with MINOCA. METHODS: We conducted an observational study of MINOCA patients recorded between July 2003 and June 2013 and followed until December 2013 for outcome events. Out of 199,163 MI admissions, 9092 consecutive unique patients with MINOCA were identified...
March 14, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29549619/comparison-of-open-and-laparoscopic-gastrectomy-in-elderly-patients
#20
Su Mi Kim, Ho Geun Youn, Ji Yeong An, Yoon Young Choi, Sung Hoon Noh, Seung Jong Oh, Tae Sung Sohn, Sung Kim
PURPOSE: The purpose of this study was to estimate surgical outcomes of elderly patients older than 80 years who received laparoscopic or open gastrectomy for gastric cancer and to identify risk factors for postoperative complications. METHODS: Two hundred forty-two elderly patients older than 80 years underwent gastric cancer surgery between January 2010 and December 2016 in three tertiary hospitals. They were divided into two groups: laparoscopic gastrectomy (N = 59) and open gastrectomy (N = 183)...
May 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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