Mao Yokota, Koji Osuka, Yusuke Ohmichi, Mika Ohmichi, Chiharu Suzuki, Masahiro Aoyama, Kenichiro Iwami, Satoru Honma, Shigeru Miyachi
Angiogenesis is one of the growth mechanisms of chronic subdural hematoma (CSDH). Pericytes have been implicated in the capillary sprouting during angiogenesis and are involved in brain ischemia and diabetic retinopathy. This study examined the pericyte expressions in CSDH outer membranes obtained during trepanation surgery. Eight samples of CSDH outer membranes and 35 samples of CSDH fluid were included. NG2, N-cadherin, VE-cadherin, Tie-2, endothelial nitric oxide synthase (eNOS), platelet-derived growth factor (PDGF) receptor-β (PDGFR-β), a well-known marker of pericytes, phosphorylated PDGFR-β at Tyr751 , and β-actin expressions, were examined using western blot analysis...
November 30, 2023: Neurologia Medico-chirurgica