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https://www.readbyqxmd.com/read/30339861/new-iridal-type-triterpenoid-derivatives-with-cytotoxic-activities-from-belamcanda-chinensis
#1
Jiayuan Li, Gang Ni, Li Li, Yanfei Liu, Zhenpeng Mai, Renzhong Wang, Dequan Yu
Eight new iridal-type triterpenoid derivatives, including two noriridals with ether bridge (1-2); two iridals lactone (3-4), four monocyclic iridals (5-8), together with five known iridals (9-14) were identified from the rhizome of Belamcanda chinensis. Their structures were elucidated on the basis of comprehensive spectroscopic methods and electronic circular dichroism (ECD) calculations. Bioassay results showed that belamcanoxide B (1) exhibited moderated cytotoxic activities against HCT-116 and MCF-7 cell lines with IC50 values of 5...
September 5, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/30333726/loss-of-arhgef6-causes-hair-cell-stereocilia-deficits-and-hearing-loss-in-mice
#2
Chengwen Zhu, Cheng Cheng, Yanfei Wang, Waqas Muhammad, Shuang Liu, Weijie Zhu, Buwei Shao, Zhong Zhang, Xiaoqian Yan, Qingqing He, Zhengrong Xu, Chenjie Yu, Xiaoyun Qian, Ling Lu, Shasha Zhang, Yuan Zhang, Wei Xiong, Xia Gao, Zhigang Xu, Renjie Chai
ARHGEF6 belongs to the family of guanine nucleotide exchange factors (GEFs) for Rho GTPases, and it specifically activates Rho GTPases CDC42 and RAC1. Arhgef6 is the X-linked intellectual disability gene also known as XLID46, and clinical features of patients carrying Arhgef6 mutations include intellectual disability and, in some cases, sensorineural hearing loss. Rho GTPases act as molecular switches in many cellular processes. Their activities are regulated by binding or hydrolysis of GTP, which is facilitated by GEFs and GTPase-activating proteins, respectively...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/30328178/cyr61-a-specific-ultra-early-biomarker-in-kidney-ischemia-reperfusion-injury
#3
Cheney Li, Long Zhao, Yanfei Wang, Lin Che, Hong Luan, Congjuan Luo, Yan Xu
AIM: Studies have shown that cysteine-rich protein 61 (Cyr61) increased in the post-ischemic human kidney tissue. However, it is still unknown whether Cyr61 can be used as a biomarker in kidney ischemia/reperfusion (I/R) injury METHODS: Microarray data were collected from GSE58438 and GSE52004. The rat I/R model was established to evaluate the mRNA and protein expression of Cyr61, localization of Cyr61 by immunohistochemical and immunofluorescence staining, and changes in serum creatinine (Scr) at the same time...
October 17, 2018: Nephrology
https://www.readbyqxmd.com/read/30316099/long-term-exposure-to-ambient-fine-particles-associated-with-asthma-a-cross-sectional-study-among-older-adults-in-six-low-and-middle-income-countries
#4
Siqi Ai, Zhengmin Min Qian, Yanfei Guo, Yin Yang, Craig A Rolling, Echu Liu, Fan Wu, Hualiang Lin
BACKGROUND: Ambient PM2.5 is considered harmful to the respiratory system. However, little has been shown about the long-term association between ambient PM2.5 and asthma. METHODS: A survey from 2007 to 2010 was conducted among adults over 50 years of age in six low- and middle- income countries (including China, India, Ghana, Mexico, Russia, and South Africa), which belonged to one part of a prospective cohort study - the Study on global AGEing and adult health...
September 24, 2018: Environmental Research
https://www.readbyqxmd.com/read/30311952/portable-fluorescence-based-microrna-detection-system-based-on-isothermal-signal-amplification-technology
#5
Zhanying Zhang, Yanfei Wang, Yanlei Li, Dongsheng Yu, Haiyan Chen, Yi Cai, Weikai Fang, Zhe Yang, Yufeng Ji, Yifu Guan, Yannan Chu, Chidong Xu
MicroRNAs (miRNAs) diagnostics can be useful for diagnosing or confirming miRNA abundance and are used in screening tests and to assess changes in miRNAs in vivo. At present, the use of traditional nucleic acid amplification assays to detect microRNAs (miRNAs) has been limited in laboratory environment because of the time, equipment, and technical expertise required to perform these assays. A specialized, rapid affordable miRNA detection system is necessary when there are limited resources or point-of-care testing needs...
October 12, 2018: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/30302147/randomized-trial-of-umbilical-incisional-hernia-in-high-risk-patients-extraction-of-gallbladder-through-subxiphoid-port-vs-umbilical-port-after-laparoscopic-cholecystectomy
#6
Min Li, Baoqiang Cao, Renhua Gong, Dengqun Sun, Peisong Zhang, Xudong Jiang, Yanfei Sheng
Introduction: Trocar site incisional hernia (TSIH) is one of the most common complications of laparoscopic surgery. Using the umbilical port as a common hole for removing the gallbladder in laparoscopic cholecystectomy is more likely to lead to TSIH than other ports. Thus, extracting the gallbladder through other ports may reduce the incidence of TSIH. Aim: To ascertain whether extraction of the gallbladder through the subxiphoid port is more beneficial for reducing umbilical incisional hernia than the umbilical port...
September 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/30301948/towards-epitaxial-graphene-p-n-junctions-as-electrically-programmable-quantum-resistance-standards
#7
Jiuning Hu, Albert F Rigosi, Mattias Kruskopf, Yanfei Yang, Bi-Yi Wu, Jifa Tian, Alireza R Panna, Hsin-Yen Lee, Shamith U Payagala, George R Jones, Marlin E Kraft, Dean G Jarrett, Kenji Watanabe, Takashi Taniguchi, Randolph E Elmquist, David B Newell
We report the fabrication and measurement of top gated epitaxial graphene p-n junctions where exfoliated hexagonal boron nitride (h-BN) is used as the gate dielectric. The four-terminal longitudinal resistance across a single junction is well quantized at the von Klitzing constant [Formula: see text] with a relative uncertainty of 10-7 . After the exploration of numerous parameter spaces, we summarize the conditions upon which these devices could function as potential resistance standards. Furthermore, we offer designs of programmable electrical resistance standards over six orders of magnitude by using external gating...
October 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30300874/dendritic-spine-loss-caused-by-alcl-3-is-associated-with-inhibition-of-the-rac-1-cofilin-signaling-pathway
#8
Xu Yang, Zheng Cao, Jian Zhang, Bing Shao, Miao Song, Yanfei Han, Yanfei Li
Aluminum (Al) has neurotoxicity that can result in cognitive dysfunction. Hippocampal dendritic spine loss is a pathological characteristic of cognitive dysfunction. Our previous study reported that Al exposure caused dendritic spine loss in the hippocampus, but the underlying mechanism remains unclear. In this study, rats were orally administered 50, 150 or 450 mg/kg of AlCl3 for 90 days. The dendritic spine density of the CA1 and DG regions was detected by Golgi-Cox staining. The F-actin/G-actin ratio, the expression of drebrin A and the components of the Rac 1/cofilin pathway were measured in the hippocampus...
October 1, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/30295183/aptamer-based-targeted-drug-delivery-systems-current-potential-and-challenges
#9
Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu, Yanfei Liu
Aptamers are single-stranded DNA or RNA with 20-100 nucleotides in length that can specifically bind to target molecules via formed three-dimensional structures. These innovative targeting molecules have attracted an increasing interest in biomedical field. Compared to traditional protein antibodies, aptamers have several advantages, such as small size, high binding affinity, specificity, good biocompatibility, high stability and low immunogenicity, which all contribute to their wide application in biomedical field...
October 8, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/30289270/evaluation-of-bacterial-contamination-in-goat-milk-powder-using-pacbio-single-molecule-real-time-sequencing-and-droplet-digital-pcr
#10
Huimin Ma, Jing Li, Xiaoxia Xi, Haiyan Xu, Laga Wuri, Yanfei Bian, Zhongjie Yu, Min Ren, Lana Duo, Yaru Sun, Zhihong Sun, Tiansong Sun, Bilige Menghe
Goat milk powder is a nutritious and easy-to-store product that is highly favored by consumers. However, the presence of contaminating bacteria and their metabolites may significantly affect the flavor, solubility, shelf life, and safety of the product. To comprehensively and accurately understand the sanitary conditions in the goat milk powder production process and potential threats from bacterial contamination, a combination of Pacific Biosciences single molecule real-time sequencing and droplet digital PCR was used to evaluate bacterial contamination in seven goat milk powder samples from three dairies...
October 5, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/30283969/investigation-on-the-growth-mechanism-of-sic-whiskers-during-microwave-synthesis
#11
Bozhen Song, Biao Zhao, Yanfei Lu, Shengnan Wei, Bingbing Fan, Xinyue Zhang, Rui Zhang
Silicon carbide (SiC) whiskers with different morphologies are fabricated by microwave heating of SiO2-coated coal mineral particles at different temperatures and different holding times in an oxygen-containing environment. The atomic diffusion processes and growth mechanism of the SiC whiskers are simulated. It is found that a closed capsule of SiO2 appears during microwave heating, within which the SiC whiskers are formed. SiC crystals can be prepared at 1100 °C for 10 min. The optimized synthesis condition is approximately 1100 °C for 20 min...
October 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/30283379/humble-leadership-psychological-safety-knowledge-sharing-and-follower-creativity-a-cross-level-investigation
#12
Yanfei Wang, Jieqiong Liu, Yu Zhu
The leadership literature has provided growing evidence regarding the power of leadership in facilitating follower creativity. Despite these advances, a noticeable omission in this body of research is humble leadership. The study extends previous research by developing a cross-level moderated mediation model and examining the roles that psychological safety and knowledge sharing may play in the relationship between humble leadership and follower creativity. Using a time-lagged data of 328 team members nested within 106 teams, the results show that: (a) psychological safety mediates the relationship between humble leadership and follower creativity; (b) knowledge sharing moderates the relationship between psychological safety and follower creativity; and (c) the indirect influence of humble leadership on follower creativity through psychological safety is stronger when knowledge sharing is high...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30271961/kir4-1-channels-in-ng2-glia-play-a-role-in-development-potassium-signaling-and-ischemia-related-myelin-loss
#13
Feier Song, Xiaoqi Hong, Jiayu Cao, Guofen Ma, Yanfei Han, Carlos Cepeda, Zizhen Kang, Tianle Xu, Shumin Duan, Jieqing Wan, Xiaoping Tong
The contribution of the inwardly rectifying K+ channel subtype Kir4.1 has been focused mainly on astrocytes, where they play important roles in the maintenance of resting membrane potential, extracellular K+ uptake, and facilitation of glutamate uptake in the central nervous system. Here, we report the role of Kir4.1 channels in NG2-glia during brain development, potassium signaling, and in an ischemic stroke disease model. Kir4.1 channels are widely expressed in NG2-glia during brain development. In the adult mouse hippocampus, Kir4...
2018: Communications biology
https://www.readbyqxmd.com/read/30269653/a-novel-variable-stiffness-flexible-manipulator-actuated-by-shape-memory-alloy-for-minimally-invasive-surgery
#14
Yanfei Cao, Feng Ju, Lei Zhang, Dongming Bai, Fei Qi, Bai Chen
This article presents a novel variable-stiffness flexible manipulator for minimally invasive surgery. Each module of the proposed manipulator contains a variable-stiffness mechanism actuated by proactive deformation of shape memory alloy. Due to low driving current, apparent mechanical deformation, suitable phase transformation temperature and biocompatibility of shape memory alloy wire actuation, it is well suited for the manipulator applied in minimally invasive surgery, where variable stiffness is urgently required...
September 29, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/30266091/manipulating-plant-rna-silencing-pathways-to-improve-the-gene-editing-efficiency-of-crispr-cas9-systems
#15
Yanfei Mao, Xiaoxuan Yang, Yiting Zhou, Zhengjing Zhang, Jose Ramon Botella, Jian-Kang Zhu
BACKGROUND: The CRISPR/Cas9 system, composed of a single-guide RNA for target recognition and a Cas9 protein for DNA cleavage, has the potential to revolutionize agriculture as well as medicine. Even though extensive work has been done to improve the gene editing activity of CRISPR/Cas9, little is known about the regulation of this bacterial system in eukaryotic host cells, especially at the post-transcriptional level. RESULTS: Here, we evaluate the expression levels of the two CRISPR/Cas9 components and the gene editing efficiency in a set of Arabidopsis mutants involved in RNA silencing...
September 28, 2018: Genome Biology
https://www.readbyqxmd.com/read/30261656/advances-in-dna-barcoding-of-toxic-marine-organisms
#16
REVIEW
Shaohua Gong, Yanfei Ding, Yi Wang, Guangze Jiang, Cheng Zhu
There are more than 200,000 marine species worldwide. These include many important economic species, such as large yellow croaker, ribbonfish, tuna, and salmon, but also many potentially toxic species, such as blue-green algae, diatoms, cnidarians, ctenophores, Nassarius spp., and pufferfish. However, some edible and toxic species may look similar, and the correct identification of marine species is thus a major issue. The failure of traditional classification methods in certain species has promoted the use of DNA barcoding, which uses short, standard DNA fragments to assist with species identification...
September 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30253347/qualitative-and-quantitative-correlation-of-physicochemical-characteristics-and-lead-sorption-behaviors-of-crop-residue-derived-chars
#17
Yanfei Li, Xian Liu, Peizhen Zhang, Xinlei Wang, Yaoyao Cao, Lujia Han
This study investigated the key physicochemical characteristics of char that control its ability to absorb Pb2+ . Three type of crop residue-derived chars and their ball milled powder were characterized using multiple approaches. The Pb2+ sorption mechanisms of biochar were caused mainly by coprecipitation reactions, which were governed by ionic minerals on chars instead of mineral crystallization (e.g., SiO2 and Al2 O3 ), while coprecipitation reactions and π electronic interaction were the dominant mechanisms of activated carbon...
September 17, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/30248664/mirna-expression-profile-of-saliva-in-subjects-of-yang-deficiency-constitution-and-yin-deficiency-constitution
#18
Yu Chen, Yanling Wu, Haiqiang Yao, Hui Luo, Bing Lin, Xiuping Zhang, Xue Liang, Ranran Sun, Shipeng Zhao, Yingshuai Li, Yanfei Zheng, Lingru Li, Qi Wang
BACKGROUND/AIMS: Based on the theory of constitution in Traditional Chinese Medicine (TCM), the Chinese Han population has been classified into nine constitutions. Of these, Yang deficiency constitution mainly exhibit cold intolerance while Yin deficiency constitution mainly exhibit heat intolerance. Some studies have been carried out to explore the modern genetic and biological basis of such constitution classification, but more remains to be done. MicroRNA (miRNA) serves as post-transcriptional regulators of gene expression and may play a role in the classification process...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30246526/fe-n-c-artificial-enzyme-activation-of-oxygen-for-dehydrogenation-and-monoxygenation-of-organic-substrates-under-mild-condition-and-cancer-therapeutic-application
#19
Fei He, Li Mi, Yanfei Shen, Toshiyuki Mori, Songqin Liu, Yuanjian Zhang
Developing highly efficient biomimetic catalysts that directly use O2 as the terminal oxidant to dehydrogenate and monoxygenate substrates with high selectivity under mild conditions has long been pursued but rarely achieved yet. Herein, we report that heterogeneous Fe-N-C, which is commonly used as an electrocatalyst for oxygen reduction reaction, had unusual biomimetic catalytic activity in both dehydrogenation and monoxygenation of a series of organic molecules (∼100% selectivity) by directly using O2 ...
October 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30245967/helioscopianoids-a-q-bioactive-jatrophane-diterpenoid-esters-from-euphorbia-helioscopia
#20
Zhenpeng Mai, Gang Ni, Yanfei Liu, Zhao Zhang, Li Li, Naihong Chen, Dequan Yu
The EtOH extracts of the whole plants of Euphorbia helioscopia afforded 17 new jatrophane diterpenoid esters, helioscopianoids A-Q ( 1 - 17 ), along with eight known compounds ( 18 - 25 ). Their structures were elucidated by extensive spectroscopic methods and Mo2 (OAc)4 -induced ECD analysis, and the structures of compounds 1 , 2 , and 7 were confirmed by X-ray crystallography. Compounds 1 - 17 were evaluated for inhibitory effects on P-glycoprotein (P-gp) in an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR) and neuroprotective effects against serum deprivation-induced and rotenone-induced PC12 cell damage...
September 2018: Acta Pharmaceutica Sinica. B
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