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https://www.readbyqxmd.com/read/30548717/systemic-disrupting-the-homeostasis-of-trna-isopentenyltransferase-causes-growth-and-development-abnormalities-in-bombyx-mori
#1
Yanfei Chen, Bingchuan Bai, Hao Yan, Feng Wen, Daoyuan Qin, Georg Jander, Qingyou Xia, Genhong Wang
Isopentenylation at A37 (i6 A37) of some transfer RNAs (tRNAs) plays a vital role in regulating the efficiency and fidelity of protein synthesis. However, whether insects, which are well-known for their highly efficient protein synthesis machinery, employ this regulatory mechanism remains uninvestigated. In the current study, a candidate tRNA isopentenyltransferase (IPT) gene with three alternative splicing isoforms (BmIPT1-BmIPT3) was identified in Bombyx mori (silkworm). Only BmIPT1 could complement a yeast mutant lacking tRNA isopentenyltransferase...
December 12, 2018: Insect Molecular Biology
https://www.readbyqxmd.com/read/30548514/eosin-y-functionalized-conjugated-organic-polymers-for-visible-light-driven-co-2-reduction-with-h-2-o-to-co-with-high-efficiency
#2
Xiaoxiao Yu, Zhenzhen Yang, Bing Qiu, Shien Guo, Peng Yang, Bo Yu, Hongye Zhang, Yanfei Zhao, Xinzheng Yang, Buxing Han, Zhimin Liu
Visible-light-driven photoreduction of CO2 to energy-rich chemicals in the presence of H2 O without any sacrifice reagent is of significance, but challenging. Herein, Eosin Y-functionalized porous polymers (PEosinY-N, N=1-3), with high surface areas up to 610 m2  g-1 , are reported. They exhibit high activity for the photocatalytic reduction of CO2 to CO in the presence of gaseous H2 O, without any photosensitizer or sacrifice reagent, and under visible-light irradiation. Especially, PEosinY-1 derived from coupling of Eosin Y with 1,4-diethynylbenzene shows the best performance for the CO2 photoreduction, affording CO as the sole carbonaceous product with a production rate of 33 μmol g-1  h-1 and a selectivity of 92 %...
November 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30547025/ideal-cardiovascular-health-and-cognitive-test-performance-testing-a-modified-index-of-life-s-simple-7-among-older-chinese-adults
#3
Theresa E Gildner, Nawi Ng, Fan Wu, Yanfei Guo, J Josh Snodgrass, Paul Kowal
Evidence suggests that cognitive decline in older adults is influenced by cardiovascular health (CVH), with metabolic and vascular mechanisms hypothesized to underlie the etiology of cognitive impairment. Research in high-income nations suggests that improved CVH is linked with decreased cognitive impairment risk, but it is unclear if this pattern is evident in low-income countries. Nationally-representative data collected in China were drawn from the World Health Organization's Study on global AGing and adult health Wave 1 (2007-2010; n = 11,295)...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/30544514/a-highly-efficient-cell-division-specific-crispr-cas9-system-generates-homozygous-mutants-for-multiple-genes-in-arabidopsis
#4
Zhengyan Feng, Zhengjing Zhang, Kai Hua, Xifeng Gao, Yanfei Mao, Jose Ramon Botella, Jian-Kang Zhu
The CRISPR/Cas9 system has been widely used for targeted genome editing in numerous plant species. In Arabidopsis , constitutive promoters usually result in a low efficiency of heritable mutation in the T1 generation. In this work, CRISPR/Cas9 gene editing efficiencies using different promoters to drive Cas9 expression were evaluated. Expression of Cas9 under the constitutive CaMV 35S promoter resulted in a 2.3% mutation rate in T1 plants and failed to produce homozygous mutations in the T1 and T2 generations...
December 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30542549/dissolution-and-homogeneous-photocatalysis-of-polymeric-carbon-nitride
#5
Chaofeng Huang, Jing Wen, Yanfei Shen, Fei He, Li Mi, Ziyu Gan, Jin Ma, Songqin Liu, Haibo Ma, Yuanjian Zhang
As a metal-free conjugated polymer, carbon nitride (CN) has attracted tremendous attention as a heterogeneous (photo)catalyst. By following the example of enzymes, making all of the catalytic sites accessible via homogeneous reactions is a promising approach toward maximizing CN activity, but hindered due to the poor solubility of CN. Herein, we report the dissolution of CN in environmentally friendly methanesulfonic acid, and homogeneous photocatalysis (two biomimetic/pharmaceutical photocatalytic oxidation reactions) driven by CN for the first time with the activity boosted up to 10-times compared to the heterogeneous counterparts...
November 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/30542532/assessment-of-a-bifendate-derivative-bearing-a-6-7-dihydro-dibenzo-c-e-azepine-scaffold-as-a-potential-anti-metastatic-agent
#6
Jingying Qiu, Wang Chen, Yanfei Jiang, Jing Chen, Yinpeng Zhang, Xiaoke Gu
Multidrug resistance (MDR) and metastasis are major causes of mortality in patients with cancer. We recently reported a bifendate derivative bearing a dibenzo[ c , e ]azepine scaffold ( 4i ) as a P-gp and BCRP-medicated MDR reversal agent. As a continuation of the previous research, its ability to inhibit cancer metastasis was investigated in MDA-MB-231 cells in the present work. Wound-healing and chamber migration assays showed that 4i could significantly attenuate the migration of MDA-MB-231 cells. Additionally, 4i obviously suppressed the invasive activity of MDA-MB-231 cells, thus displaying potential anti-metastasis activity...
November 1, 2018: MedChemComm
https://www.readbyqxmd.com/read/30536473/plumbagin-induces-autophagy-and-apoptosis-of-smmc-7721-cells-in-vitro-and-in-vivo
#7
Yuning Lin, Yongxin Chen, Shengshan Wang, Jing Ma, Yue Peng, Xianling Yuan, Beibei Lv, Wanjun Chen, Yanfei Wei
Plumbagin (PL), an active naphthoquinone compound, has been demonstrated to be a potential anticancer agent. However, the underlying anticancer mechanism is not fully understood. In this study, the human hepatocellular carcinoma (HCC) SMMC-7721 cell line was studied in an in vitro model. The cell proliferation was inhibited by PL in a dose- and time-dependent manner. Electron microscopy, acridine orange staining, and immunofluorescence were used to evaluate autophagosome formation and LC3 protein expression in PL-treated SMMC-7721 cells...
December 9, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30535164/advantages-of-serum-anti-m%C3%A3-llerian-hormone-as-a-marker-for-polycystic-ovarian-syndrome
#8
Xinyan Shi, Duo Peng, Yanfei Liu, Xiaofen Miao, Hui Ye, Jun Zhang
Objective: To evaluate the advantages of using anti-Müllerian hormone (AMH) in the diagnosis of polycystic ovary syndrome (PCOS). Methods: We compared data from 56 Han Chinese patients with PCOS and 52 female control Han Chinese individuals in terms of biochemical markers and the antral follicle count (AFC). Then, the correlation between serum AMH levels and various endocrine and metabolic factors was analyzed. We generated receiver operating characteristic (ROC) curves to assess the usefulness of AMH, AFC, the luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio, and testosterone (T), to discriminate between the PCOS and control groups...
December 10, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/30523237/-significance-of-the-items-for-dizziness-handicap-inventory-in-differential-diagnosis-of-benign-paroxysmal-positional-vertigo
#9
Yanfei Li, Jingjing Li, Qi Li, Xiaolong Liu, Xuxing Hong, Youli Liu
To explore the value of items for the Chinese version of Dizziness Handicap Inventory (DHI) in differential diagnosis of benign paroxysmal positional vertigo (BPPV) in patients with vertigo or dizziness first coming to the outpatient clinic.
 Methods: A total of 322 patients with vertigo or dizziness, who came from Nanfang Hospital, Southern Medical University, were enrolled from April 2016 to February 2017. The Chinese version of DHI and Visual Analogue Scale (VAS) were completed by themselves. After detailed vestibular function examination, the patients were divided into a BPPV group, a normal vestibular group, and a abnormal vestibular group...
October 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/30517681/serum-cystatin-c-levels-in-twin-pregnancy-versus-singleton-pregnancy
#10
Jianming Peng, Wen Wang, Lei Zheng, Yanfei Guan, Guicheng Ye, Huichun Tong, Ying Wang, Qian Wang
Objective: To explore whether there was an increased secretion of cystatin C (Cys C) in twin pregnancy. Methods: Patients with a total of 281 singleton pregnancies (including 38 patients with preeclampsia) and 72 twin pregnancies, as well as 42 patients who were not pregnant, were included in this study. We tested levels of serum Cys C, creatinine, and uric acid, along with the estimated glomerular filtration rate (eGFR), in different groups. Results: The levels of serum Cys C in all 3 trimesters for women with twin pregnancy were much higher than those in the corresponding trimesters for women with singleton pregnancy...
December 4, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/30515906/thyrotroph-embryonic-factor-is-downregulated-in-bladder-cancer-and-suppresses-proliferation-and-tumorigenesis-via-the-akt-foxos-signalling-pathway
#11
Jianan Yang, Bin Wang, Han Chen, Xuhong Chen, Jing Li, Yanfei Chen, Daozhang Yuan, Shunsheng Zheng
OBJECTIVES: Thyrotroph embryonic factor (TEF) plays an important role in several different processes in normal human cells; however, its function in malignant cells has not been fully elucidated. MATERIALS AND METHODS: The mRNA levels of TEF in 408 bladder cancer (BC) samples from the Cancer Genome Atlas (TCGA) database were analysed in depth. Next, the expression of TEF in 7 BC cell lines was compared to that in normal bladder epithelial cells. The cell count, colony formation and anchorage-independent growth assays as well as a nude mouse xenograft model were utilized to examine the effects of TEF on proliferation and tumorigenesis...
December 4, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/30514338/combined-surgical-orthodontic-treatment-of-patients-with-cleidocranial-dysplasia-case-report-and-review-of-the-literature
#12
REVIEW
Yanfei Zhu, Yin Zou, Qian Yu, Huijun Sun, Sixuan Mou, Shuhua Xu, Min Zhu
OBJECTIVES: To study the present treatment situation and investigate a better orthodontic approach for patients with cleidocranial dysplasia (CCD) through systematically reviewing the published cases and to conclude the surgical-orthodontic treatment experience of cleidocranial dysplasia. METHODS: A comprehensive search for studies published through to April 10, 2018 was conducted using the Pubmed, Web of Science, and Embase databases. The CCD cases treated with the approach combining surgical exposure and orthodontic treatment were concluded...
December 4, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/30506709/altered-levels-of-focal-adhesion-and-extracellular-matrix-receptor-interacting-proteins-were-identified-in-hailey-hailey-disease-by-quantitative-itraq-proteome-analysis
#13
Dingwei Zhang, Jia Huo, Ruilian Li, Yanfei Zhang, Zhenghui Wang, Xiaoli Li
Benign chronic familial pemphigus or Hailey-Hailey disease (HHD, OMIM 169600) is a rare, autosomal dominant blistering skin disorder characterized by suprabasal cell separation (acantholysis) of the epidermis. To date, the proteomic changes in skin lesions from HHD patients has not been reported yet. In this study, a sample of skin lesions from HHD patients was collected for isobaric tags for relative and absolute quantitation to analyze proteome changes compared with unaffected individuals. The 134 differentially expressed proteins were assigned to at least one Gene Ontology term, and 123 annotated proteins with significant matches were assigned to 187 known metabolic or signaling pathways listed in the Kyoto Encyclopedia of Genes and Genomes...
December 3, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30503499/screening-for-therapeutic-targets-of-tumor-angiogenesis-signatures-in-31-cancer-types-and-potential-insights
#14
Jiamin Peng, Huiyu Xu, Yuan Chen, Wei Wang, Lifen Zhu, Yanfei Shao, Jianchao Wang
Tumor vessel normalization can increase pericyte coverage, perfusion efficiency and immune infiltration, while reducing hypoxia, vessel leakage, CTC and metastasis. In this study, we systemically presented the expression pattern of tumor angiogenesis gene signatures in 31 cancer types and its association with immune infiltration and cancer metastasis. Specifically, READ, COAD etc. have relatively similar expression patterns with low GPAGs and high PPAGs. Patients with this expression pattern may benefit from tumor vessel normalization...
November 29, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30502384/methotrexate-induces-astrocyte-apoptosis-by-disrupting-folate-metabolism-in-the-mouse-juvenile-central-nervous-system
#15
Yanfei Shao, Biqin Tan, Jing Shi, Qian Zhou
Methotrexate (MTX) is a folic acid antagonist and widely used for acute lymphoblastic leukemia (ALL) in children. MTX is associated with acute and chronic neurotoxicity during treatment, however the underlying mechanism is still poorly understood. In this study we investigate whether MTX is neurovirulent to astrocytes in the Central Nervous System (CNS) of adolescent mice. We demonstrated that MTX induced severe cytotoxicity in C6 astrocyte-like cell line and rat primary cultures of astrocytes in a dose-dependent manner...
November 28, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/30486241/simulation-of-eccentric-impact-of-square-and-rectangular-composite-laminates-embedded-with-sma
#16
Min Sun, Mengzhou Chang, Zhenqing Wang, Hao Li, Yanfei Liu
In the present work, we study the low velocity impact, both central and eccentric, on square and rectangular laminated composite plates with embedded shape memory alloy (SMA) wires, which are stitched on the top and bottom surfaces of the plate, by using the finite element method. In finite element methods (FEM) simulations, a super-elastic SMA constitutive model is implemented in Abaqus/Explict by using a user defined material subroutine to describe the behaviors of SMAs. The three-dimensional (3D) Hashin failure criterion is adopted to model the damage initiation of laminated composite plates...
November 26, 2018: Materials
https://www.readbyqxmd.com/read/30485509/expression-of-dec2-enhances-chemosensitivity-by-inhibiting-stat5a-in-gastric-cancer
#17
Hongyu Li, Xiaoli Ma, Dongjie Xiao, Yanfei Jia, Yunshan Wang
Gastric cancer (GC) is one of the most common cancers. Resistance to 5-fluorouracil (5-Fu)-based chemotherapy is a major cause of treatment failure followed by the poor prognosis of patients. In GC, it was reported that human differentiated embryonic chondrocyte-expressed gene 2 (DEC2), suppressed tumor proliferation and metastasis, but the effect of DEC2 on chemosensitivity of GC cells was unknown. In our study, we found that DEC2 can obviously increase the sensibility of GC cells to 5-Fu by promoting 5-Fu-induced apoptosis...
November 28, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30484308/directly-converting-syngas-to-linear-%C3%AE-olefins-over-core-shell-fe3o4-mno2-catalysts
#18
Jie Wang, Yanfei Xu, Guangyuan Ma, Jianghui Lin, Hongtao Wang, Chenghua Zhang, Mingyue Ding
Converting syngas to value-added chemicals via Fischer-Tropsch synthesis (FTS) has attracted much attention, whereas the direct hydrogenation of CO to heavy olefins, especially linear α-olefins (LAOs), remains a challenge. In this study, we designed a core-shell Fe3O4@MnO2 catalyst to realize the direct conversion of syngas to LAOs with high efficiency. This catalyst exhibited an enhanced selectivity of 79.60% for total alkenes and 64.95% for C4+ alkenes, 91% of which are LAOs, at a CO conversion of approximately 75%...
November 28, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30482236/long-noncoding-rna-linc00511-contributes-to-breast-cancer-tumourigenesis-and-stemness-by-inducing-the-mir-185-3p-e2f1-nanog-axis
#19
Guanming Lu, Yueyong Li, Yanfei Ma, Jinlan Lu, Yongcheng Chen, Qiulan Jiang, Qiang Qin, Lifeng Zhao, Qianfang Huang, Zhizhai Luo, Shiqing Huang, Zhongheng Wei
BACKGROUND: Emerging evidence have illustrated the vital role of long noncoding RNAs (lncRNAs) long intergenic non-protein coding RNA 00511 (LINC00511) on the human cancer progression and tumorigenesis. However, the role of LINC00511 in breast cancer tumourigenesis is still unknown. This research puts emphasis on the function of LINC00511 on the breast cancer tumourigenesis and stemness, and investigates the in-depth mechanism. METHODS: The lncRNA and RNA expression were measured using RT-PCR...
November 27, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30481499/neuroprotective-role-of-hyperforin-on-aluminum-maltolate-induced-oxidative-damage-and-apoptosis-in-pc12-cells-and-sh-sy5y-cells
#20
Haoran Wang, Bing Shao, Hongyan Yu, Feibo Xu, Peiyan Wang, Kaiyuan Yu, Yanfei Han, Miao Song, Yanfei Li, Zheng Cao
Many reports demonstrated that aluminum maltolate (Almal) has potential toxicity to human and animal. Our study has demonstrated that Almal can induce oxidative damage and apoptosis in PC12 cells and SH-SY5Y Cells, two in vitro models of neuronal cells. Hyperforin (HF) is a well-known antioxidant, anti-inflammatory, anti-amyloid and anti-depressant compound extracted from Hypericum perforatum extract. Here, we investigated the neuroprotective effect of HF against Almal-induced neurotoxicity in cultured PC12 cells and SH-SY5Y cells, mainly caused by oxidative stress...
November 24, 2018: Chemico-biological Interactions
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