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Pleural effusion and cancer

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https://www.readbyqxmd.com/read/29792037/the-effect-of-iodopovidone-versus-bleomycin-in-chemical-pleurodesis
#1
Reza Bagheri, Marzieh Noori, Maryam Rajayi, Davood Attaran, Amir Mohammad Hashem Asna Ashari, Shahrzad Mohammadzadeh Lari, Reza Basiri, Fariba Rezaeetalab, Reza Afghani, Maryam Salehi
Background Malignant pleural effusion continues to be a common problem in patients with metastatic disease. This study was conducted to compare the efficacy and safety of bleomycin pleurodesis with povidone-iodine pleurodesis through a chest drain as palliative treatment for recurrent malignant pleural effusion. Methods Sixty cancer patients (36 males and 24 females) with recurrent malignant pleural effusion were enrolled in a prospective randomized trial. Thirty patients received povidone-iodine pleurodesis and 30 received bleomycin pleurodesis...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29785404/enhanced-suppressive-activity-of-regulatory-t-cells-in-the-microenvironment-of-malignant-pleural-effusions
#2
Joanna Budna, Mariusz Kaczmarek, Agata Kolecka-Bednarczyk, Łukasz Spychalski, Piotr Zawierucha, Joanna Goździk-Spychalska, Michał Nowicki, Halina Batura-Gabryel, Jan Sikora
Cancer metastatic spread to serous cavity causes malignant pleural effusions (MPEs), indicating dismal prognosis. Tumor microenvironment can implement suppressive activity on host immune responses. Thus, we investigated the prevalence of Tregs and the relationship between them and TGF- β and IL-10 concentrations and measured expression of FOXP3 , CTLA-4 , CD28 , and GITR genes, as well as protein expression of selected genes in benign effusions and MPEs. The percentage of Tregs was determined by means of multicolor flow cytometry system...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29764505/xenograft-tumors-derived-from-malignant-pleural-effusion-of-the-patients-with-non-small-cell-lung-cancer-as-models-to-explore-drug-resistance
#3
Yunhua Xu, Feifei Zhang, Xiaoqing Pan, Guan Wang, Lei Zhu, Jie Zhang, Danyi Wen, Shun Lu
BACKGROUND: Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions show dramatic responses to specific tyrosine kinase inhibitors (TKIs); however, after 10-12 months, secondary mutations arise that confer resistance. We generated a murine xenograft model using patient-derived NSCLC cells isolated from the pleural fluid of two patients with NSCLC to investigate the mechanisms of resistance against the ALK- and EGFR-targeted TKIs crizotinib and osimertinib, respectively...
May 9, 2018: Cancer communications
https://www.readbyqxmd.com/read/29761620/polyserositis-a-diagnostic-challenge
#4
Inés Losada, Juan González Moreno, Nuria Roda, Lola Ventayol, Yolanda Borjas, Francisco Javier Domínguez, Victoria Fernández Vaca, Mercedes García Gasalla, Antoni Payeras
Polyserositis (PS) is the inflammation, with effusion, of different serous membranes. It has been associated with different aetiologiesbut the aetiology of PS remains unknown in a high percentage of patients. The general objective of this retrospective study was to analyse the aetiology of PS cases seen at Son Llàtzer Hospital in an eleven-year period. Other objectives were to determine epidemiological, clinical, and analytical characteristics of these patients. Ninety-two patients were included in the study...
May 14, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29760834/a-case-series-of-two-patients-presenting-with-pericardial-effusion-as-first-manifestation-of-non-small-cell-lung-cancer-with-braf-mutation-and-expression-of-pd-l1
#5
Muhammad Mufti, Steven Ching, Sassan Farjami, Sharareh Shahangian, Serap Sobnosky
Lung cancer is the number one cause of cancer-related deaths in the United States. Involvement of pericardium occurs once cancer has progressed to stage IV which can cause massive effusion in the pericardial sac. This can lead to cardiac tamponade which can be fatal very quickly if untreated. The following is a two patient case series in which both patients presented with large pericardial effusion. The first patient sought medical attention due to new onset palpitations and was found to have hemorrhagic pericardial effusion and pulmonary embolism (PE)...
April 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29738763/3d-culture-system-containing-gellan-gum-restores-oncogene-dependence-in-ros1-rearrangements-non-small-cell-lung-cancer
#6
Bo Gong, Tomoko Oh-Hara, Naoya Fujita, Ryohei Katayama
The ROS1 fusion gene has been identified in approximately 1% of non-small cell lung cancer (NSCLC) cases. Several clinical studies have highlighted ROS1 as a promising therapeutic target because crizotinib, a multi-targeted drug against ROS1, ALK, and the MET proto-oncogene, has elicited remarkable responses in ROS1-rearrangements NSCLC. However, acquired resistance mediated by ROS1 kinase domain mutations has been identified and a system to assess ROS1 inhibitors for these resistant mutations is necessary for the promotion of drug development...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29736123/prognostic-factors-of-malignant-pleural-effusion-among-palliative-care-outpatients-a-retrospective-study
#7
Jenifer Jeba, Renitha M Cherian, Balamugesh Thangakunam, Reena George, J Visalakshi
Background: Malignant pleural effusion (MPE) has varied survival and indicates advanced disease. LENT prognostic score is the first validated score used for MPE. This study assessed the role of LENT among palliative care cancer patients and assessed different patient, tumor, and treatment related factors that may affect survival. Methods: A retrospective study of advanced cancer patients with MPE, seen in palliative care outpatient clinic (2013-2015) until death, was done...
April 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29733516/clinical-significance-of-calcium-binding-protein-s100a8-and-s100a9-expression-in-non-small-cell-lung-cancer
#8
He Huang, Qingdong Huang, Tingyu Tang, Liang Gu, Jianzong Du, Zhijun Li, Xiaoling Lu, Xiaoxi Zhou
BACKGROUND: The purpose of this study was to evaluate the correlation between calcium-binding protein S100A8 and S100A9 expression in non-small cell lung cancer (NSCLC) and patients' clinical features. METHODS: Fifty-two NSCLC patients who underwent surgery at Zhejiang Hospital from February 2014 to January 2016 were included in this study. Calcium-binding protein S100A8 and S100A9 expression patterns in cancer and para-cancer tissues were examined by immunohistochemistry assay...
May 7, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29731641/combination-of-long-noncoding-rna-malat1-and-carcinoembryonic-antigen-for-the-diagnosis-of-malignant-pleural-effusion-caused-by-lung-cancer
#9
Wan-Wei Wang, Xi-Lei Zhou, Ying-Jian Song, Chang-Hua Yu, Wei-Guo Zhu, Yu-Suo Tong
Purpose: Long noncoding RNAs (lncRNAs) are present in body fluids, but their potential as tumor biomarkers has never been investigated in malignant pleural effusion (MPE) caused by lung cancer. The aim of this study was to assess the clinical significance of lncRNAs in pleural effusion, which could potentially serve as diagnostic and predictive markers for lung cancer-associated MPE (LC-MPE). Patients and methods: RNAs from pleural effusion were extracted in 217 cases of LC-MPE and 132 cases of benign pleural effusion (BPE)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29729664/complete-response-to-orally-administered-melphalan-in-malignant-pleural-effusion-from-an-occult-female-genital-organ-primary-neoplasm-with-brca1-2-mutations-a-case-report
#10
Frank S Fan, Chung-Fan Yang
BACKGROUND: Definite diagnosis of metastasis from unknown primary depends on a comprehensive immunohistochemical investigation of tumor specimen. Accurate identification of the origin site usually helps a lot in choosing the most appropriate treatment. Molecular characterization provides more chance of a cure. Echoing modern medical development, BRCA1/2 mutations have been correlated with high efficiency of poly(adenosine diphosphate-ribose) polymerase inhibitors in ovarian cancer. While a previous case report demonstrated a surprising cure of platinum-resistant ovarian cancer with BRCA2 mutation by orally administered melphalan...
May 6, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29723397/early-results-of-lower-dose-dasatinib-50-mg-daily-as-frontline-therapy-for-newly-diagnosed-chronic-phase-chronic-myeloid-leukemia
#11
Kiran Naqvi, Elias Jabbour, Jeffrey Skinner, Musa Yilmaz, Alessandra Ferrajoli, Prithviraj Bose, Philip Thompson, Yesid Alvarado, Nitin Jain, Koichi Takahashi, Jan Burger, Zeev Estrov, Gautam Borthakur, Naveen Pemmaraju, Shilpa Paul, Jorge Cortes, Hagop M Kantarjian
BACKGROUND: Dasatinib is a potent BCR-ABL1 and Src family tyrosine kinase inhibitor. It is approved at a dose of 100 mg orally daily for the treatment of chronic myeloid leukemia in chronic phase (CML-CP). This dose schedule is associated with myelosuppression and pleural effusions. Anecdotal data suggest that lower doses may be as effective and less toxic. The aim of this study was to assess the efficacy and safety of a lower dose of dasatinib (50 mg daily) in patients with newly diagnosed CML-CP...
May 3, 2018: Cancer
https://www.readbyqxmd.com/read/29714452/increased-micronucleus-count-predicts-malignant-behavior-in-pleural-effusion-fluid
#12
Tuba Dilay Kökenek Ünal, İpek Çoban
Background/aim: Micronucleus (MN) frequency is used as a biomarker of chromosomal damage, genome instability, and cancer risk. The aim of this study was to evaluate the diagnostic usefulness of MN frequency to differentiate between malignant and benign pleural effusion samples. Materials and methods: Retrospectively, 78 pleural fluid cytology samples (including 20 cases of benign reactive mesothelial cells, 22 cases of suspicious cytology, and 36 cases of malignant cytology) were examined. The number of micronucleated cells in 1000 well- preserved cells was counted...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29713652/natural-killer-cells-from-malignant-pleural-effusion-are-endowed-with-a-decidual-like-proangiogenic-polarization
#13
Annalisa Bosi, Silvia Zanellato, Barbara Bassani, Adriana Albini, Alessandra Musco, Maria Cattoni, Matteo Desio, Elisa Nardecchia, Davide Giuseppe D'Urso, Andrea Imperatori, Lorenzo Dominioni, Douglas M Noonan, Lorenzo Mortara, Antonino Bruno
Natural killer (NK) cells are crucial in tumor recognition and eradication, but their activity is impaired in cancer patients, becoming poorly cytotoxic. A particular type of NK cells, from the decidua, has low cytotoxicity and shows proangiogenic functions. We investigated whether NK cells from peripheral blood (PB) and pleural effusions of patients develop decidual-like NK phenotype and whether exposure to IL-2 can restore their killing ability in the presence of pleural fluids. NK cells from pleural effusion of patients with inflammatory conditions (iPE, n  = 18), primary tumor (ptPE, n  = 18), and metastatic tumor (tmPE, n  = 27) acquired the CD56bright CD16- phenotype...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29709051/thoracic-ultrasound-for-the-detection-of-rib-metastases-of-non-small-cell-lung-cancer
#14
Ioannis Tomos, Nikos Tziolos, Thomas Raptakis, Dimitra Kavatha
Transthoracic ultrasound has lately emerged as a useful diagnostic tool for respiratory physicians in the diagnosis of diverse pulmonary diseases, usually including pleural effusion and pneumothorax. However, the use of chest ultrasound may be also critical in the evaluation of chest wall diseases. Therefore, we present an interesting case of a patient with metastases of lung cancer to the rib, detected during the chest wall ultrasound examination. By representing a non-invasive, surface-imaging technique with several advantages, chest ultrasound may evolve to a valid, bed-side diagnostic tool for the diagnosis and follow up of lung cancer with metastases in the chest wall...
2018: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29707109/mir-21-over-expression-and-programmed-cell-death-4-down-regulation-features-malignant-pleural-mesothelioma
#15
Lorenzo Nicolè, Rocco Cappellesso, Tiziana Sanavia, Vincenza Guzzardo, Ambrogio Fassina
Background: Differential diagnosis between malignant pleural mesothelioma (MPM) and benign mesothelial conditions is still challenging and there is a lack of useful markers. Programmed cell death 4 (PDCD4) is a well-known tumor suppressor gene in several cancers, its post-transcriptional activity is directly controlled by miR-21, whose over-expression has been recently reported in MPM compared to normal mesothelium. Aim of this study was to test this suppressor gene as a possible new marker of malignant transformation in mesothelial cells, as well as a new prognostic marker...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29701337/the-first-24-robotic-surgeries-of-hospital-da-luz
#16
João Eurico Reis, João Santos Silva, Ana Rita Costa, Fernando Palma Martelo
INTRODUCTION: Robotic assisted thoracic surgery (RATS) has been growing all over the world, presenting itself as an improvement over video-assisted thoracic surgery (VATS). The main advantages are the precision of the movements, as well as the three-dimensional vision with the consequent perception of the depth of the surgical field. Thus, technically more difficult procedures, such as anatomic segmentectomies and bronchoplastic resections, are facilitated. This surgical approach also improves the quality of mediastinal lymph node dissection, extremely important in lung cancer patients...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29695936/invasive-meningococcal-disease-without-meningitis-a-forgotten-diagnosis
#17
Saqib Walayat, Nooreen Hussain, Abdullah H Malik, Elsa Vazquez-Melendez, Bhagat S Aulakh, Teresa Lynch
Neisseria meningitidis , a Gram-negative diplococcus, is an uncommon cause of pneumonia. There have been only about 344 cases reported worldwide from 1906 to 2015. To our knowledge, there have been only 3 cases reported in the USA in the past 2 decades. We present a case of a 72-year-old male with a past medical history of severe COPD, obstructive sleep apnea, and stage I lung cancer status post-stereotactic body radiation therapy 1 year ago, who was admitted with a 6-day history of productive cough with yellowish sputum, shortness of breath, extreme myalgias, and fatigue...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29693703/the-role-of-vegf-in-the-diagnosis-and-treatment-of-malignant-pleural-effusion-in-patients-with-non%C3%A2-small-cell-lung-cancer-review
#18
Yao Chen, Nicholas W Mathy, Hongda Lu
Malignant pleural effusion (MPE) is a severe medical condition, which can result in breathlessness, pain, cachexia and reduced physical activity. It can occur in almost all types of malignant tumors; however, lung cancer is the most common cause of MPE, accounting for ~1/3 of clinical cases. Although there are numerous therapeutic approaches currently available for the treatment of MPE, none are fully effective and the majority can only alleviate the symptoms of the patients. Vascular endothelial growth factor (VEGF) has now been recognized as one of the most important regulatory factors in tumor angiogenesis, which participates in the entire process of tumor growth through its function to stimulate tumor angiogenesis, activate host vascular endothelial cells and promote malignant proliferation...
April 23, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29690982/-malignant-pleural-mesothelioma
#19
Sajitha Sophia Sritharan, Jens Lundby Frandsen, Øyvind Omland, Jens Meldgaard Bruun
Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. The disease is of importance, since the incidence in Denmark is increasing despite cessation of the use of asbestos in the 1980s. MPM has a long latency period, and the first symptom is often dyspnoea, typically caused by pleural effusion. The diagnosis is a challenge, because cytology often is non-conclusive, and thoracoscopy is needed to obtain biopsies for immunohistochemistry. The occupational history is important, since the patients are entitled to compensation...
April 9, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29684955/-a-case-of-sarcomatoid-squamous-cell-carcinoma-of-the-penis
#20
Atsushi Wanifuchi, Takashi Shimizu, Hiroshi Hotta
A 74-year-old man presented to our hospital with the swelling of penis in May 2016. Physical examination revealed a goose egg-sized lump at the tip of the penis under foreskin. After dorsal skin incision we confirmed the 7 cm tumor on the inner preputial skin and then resected the tumor with circumcision. Histopathological examination revealed sarcomatoid squamous cell carcinoma of the penis. Computed tomography (CT) revealed swelling of bilateral inguinal lymph nodes, and we performed partial penectomy with bilateral superficial inguinal lymph node dissection in July 2016...
February 2018: Hinyokika Kiyo. Acta Urologica Japonica
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