keyword
https://read.qxmd.com/read/12920247/hca587-antigen-expression-in-normal-tissues-and-cancers-correlation-with-tumor-differentiation-in-hepatocellular-carcinoma
#21
COMPARATIVE STUDY
Bing Li, Xiao-Ping Qian, Xue-Wen Pang, Wan-Zhong Zou, Yu-Ping Wang, Hong-Yan Wu, Wei-Feng Chen
The HCA587 gene, identified by serological analysis of recombinant cDNA expression library (SEREX) from a hepatocellular carcinoma (HCC) patient, encodes a new member of cancer-testis antigens. HCA587 mRNA expression in normal tissues and cancers has been previously reported. To estimate its immunogenicity to induce immune response, it is essential to analyze HCA587 expression at the protein level. In this study anti-HCA587 polyclonal antibody, termed "TC-1," was generated, and the expression of HCA587 protein was assessed by immunohistochemical staining in a panel of normal and tumor tissue sections...
August 2003: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://read.qxmd.com/read/12823710/the-angiogenic-receptor-kdr-is-widely-distributed-in-human-tissues-and-tumours-and-relocates-intracellularly-on-phosphorylation-an-immunohistochemical-study
#22
JOURNAL ARTICLE
M Stewart, H Turley, N Cook, F Pezzella, G Pillai, D Ogilvie, S Cartlidge, D Paterson, C Copley, J Kendrew, C Barnes, A L Harris, K C Gatter
AIMS: Angiogenesis is an important factor in tumour growth and metastasis. Vascular endothelial growth factor receptor 2 (VEGFR-2) or KDR plays a crucial role in angiogenesis. The aim of this study was to raise and characterize antibodies against phosphorylated KDR which could be used for studies on human tissues to assess KDR activation and novel inhibitors of KDR activation in clinical trials. METHODS AND RESULTS: Three monoclonal antibodies and one rabbit polyclonal antiserum were produced...
July 2003: Histopathology
https://read.qxmd.com/read/12621485/fatal-ebv-related-post-transplant-lymphoproliferative-disorder-lpd-after-matched-related-donor-nonmyeloablative-peripheral-blood-progenitor-cell-transplant
#23
JOURNAL ARTICLE
K W Zamkoff, S Bergman, M W Beaty, D H Buss, M J Pettenati, D D Hurd
A 39-year-old male underwent a nonmyeloablative stem cell transplant (NMAPBPCT) from his HLA-matched sister for recurrent anaplastic large cell lymphoma in CR-2, receiving fludarabine, cyclophosphamide, and rabbit antithymocyte globulin for the preparative therapy. The patient was readmitted on day+33 for persistent culture-negative fevers. He rapidly developed marked elevations of alkaline phosphatase and bilirubin. Liver biopsy showed a periportal infiltrate of large immunoblastic appearing cells. The tumor cells did not stain for CD3/CD20/CD30 and alk protein, but did stain for CD79a/LCA and CD43...
February 2003: Bone Marrow Transplantation
https://read.qxmd.com/read/12140761/human-rgr-transforming-activity-and-alteration-in-t-cell-malignancies
#24
JOURNAL ARTICLE
Peter Leonardi, Ezra Kassin, Inmaculada Hernandez-Muñoz, Roberto Diaz, Giorgio Inghirami, Angel Pellicer
We have previously identified the oncogene rgr (ralGDS related) in DNA derived from a rabbit squamous cell carcinoma. Here we describe the identification of the human orthologue of the rabbit rgr gene termed hrgr (human ralGDS related). Four alternatively spliced full-length hrgr transcripts were isolated from normal human testes and liver libraries. Truncation of hrgr confers transforming ability to its cDNA. Using a RT-PCR assay we have been able to detect the expression of an abnormally truncated transcript in several human T-cell lymphoma lines, and in fresh tissue samples of patients with T-cell malignancies...
August 1, 2002: Oncogene
https://read.qxmd.com/read/12038857/lymphoma-in-a-rabbit-histopathological-and-immunohistochemical-findings
#25
JOURNAL ARTICLE
L Gómez, A Gázquez, V Roncero, C Sánchez, M E Durán
Lymphoma is a very common lymphoid neoplasm in domestic animals, but few naturally occurring cases have been reported in rabbits. It presents at different sites within rabbits and, although the macroscopic pattern tends to be similar, different cell populations may be involved. This report describes a case of spontaneous lymphoma ocurring in a two-and-a-half-year-old pet Dutch dwarf rabbit. T and B lymphocyte infiltrates were observed in skin, lung, kidney, liver, intestine and lymph nodes, in each case affecting one or more tissue structures...
May 2002: Journal of Small Animal Practice
https://read.qxmd.com/read/11869943/allogeneic-transplantation-after-reduced-conditioning-in-high-risk-patients-is-complicated-by-a-high-incidence-of-acute-and-chronic-graft-versus-host-disease
#26
JOURNAL ARTICLE
Johannes Schetelig, Nicolaus Kröger, Thomas K Held, Christian Thiede, Andreas Krusch, Tatjana Zabelina, Marc Dubiel, Oliver Rick, Martin Bornhäuser, Gerhard Ehninger, Axel R Zander, Wolfgang Siegert
Background and Objectives. We studied the toxicity and efficacy of reduced intensity conditioning followed by allogeneic stem cell transplantation in 50 patients over 50 years old or with relative contraindications against myeloablative regimens. Diagnoses were chronic myeloid leukemia (n=15), acute myeloid leukemia (n=9), myelodysplastic syndromes (n=9), lymphoma (n=11) and refractory solid tumors (n=6). Design and Methods. Donors were identical siblings (n=25), non-identical family members (n=6) and unrelated volunteers (n=19)...
March 2002: Haematologica
https://read.qxmd.com/read/11568007/hv-mne-a-novel-lymphocryptovirus-related-to-epstein-barr-virus-induces-lymphoma-in-new-zealand-white-rabbits
#27
JOURNAL ARTICLE
M G Ferrari, E D Rivadeneira, R Jarrett, L Stevceva, S Takemoto, P Markham, G Franchini
HV(MNE) is a novel Epstein-Barr (EBV)-like virus isolated from a Macaca nemestrina with CD8(+) T-cell mycosis fungoides-cutaneous T-cell lymphoma. Here it is demonstrated that intravenous inoculation of irradiated HV(MNE)-infected T cells or cell-free virus from the J94356(PBMC) cell line in New Zealand White rabbits results in seroconversion to the viral capsid antigen (VCA) of EBV; all animals that seroconverted to VCA developed malignant lymphoma within months of inoculation. In contrast, control rabbits, inoculated with heat-inactivated culture supernatants from the same cell line, failed to seroconvert to VCA and did not develop disease...
October 1, 2001: Blood
https://read.qxmd.com/read/11345042/cysteine-proteinase-inhibitor-level-in-tumor-and-normal-tissues-in-control-and-cured-mice
#28
JOURNAL ARTICLE
O N Poteryaeva, O V Falameyeva, T A Korolenko, V I Kaledin, S J Djanayeva, J W Nowicky, J Sandula
Cystatin C is the best known extracellular endogenous cysteine proteinase inhibitor and has been studied as a possible index of tumor growth and as a marker of the effectiveness of antitumor therapy. The aim of this study was to evaluate cystatin C concentrations in murine tumor tissues (compared with other organs not directly involved with tumor development, such as the liver and spleen) during treatment with several antitumor drugs (Ukrain and/or cyclophosphane). Cystatin C concentrations in murine tissues and biological fluids was determined by enzyme-linked immunosorbent (ELISA) assay...
2000: Drugs Under Experimental and Clinical Research
https://read.qxmd.com/read/10946281/the-iga-igm-receptor-expressed-on-a-murine-b-cell-lymphoma-is-poly-ig-receptor
#29
JOURNAL ARTICLE
J M Phillips-Quagliata, S Patel, J K Han, S Arakelov, T D Rao, M J Shulman, S Fazel, R B Corley, M Everett, M H Klein, B J Underdown, B Corthésy
T560, a mouse B lymphoma that originated in gut-associated lymphoid tissue, expresses receptors that bind dimeric IgA and IgM in a mutually inhibitory manner but have little affinity for monomeric IgA. Evidence presented in this paper indicates that the receptor is poly-Ig receptor (pIgR) known in humans and domestic cattle to bind both IgA and IgM. The evidence includes the demonstration that binding of IgM is J chain dependent, and that pIg-precipitated receptor has an appropriate Mr of 116-120 kDa and can be detected on immunoblots with specific rabbit anti-mouse pIgR...
September 1, 2000: Journal of Immunology
https://read.qxmd.com/read/10651055/spontaneous-lymphoma-in-a-japanese-white-rabbit
#30
JOURNAL ARTICLE
K Shibuya, M Tajima, K Kanai, M Ihara, T Nunoya
Lymphoma was observed in a 4-month-old female Japanese White rabbit. Grossly, the markedly enlarged mesenteric lymph nodes, prominent Peyer's patches of jejunum, splenomegaly, and enlargement of tracheobronchial lymph nodes, adrenal glands and ovaries were observed. Histologically, neoplastic lymphoid cells proliferated diffusely showing frequent mitotic figures and a characteristic 'starry sky' appearance. Their basophilic cytoplasm contained a few lipid droplets. The mesenteric lymph nodes, Peyer's patches of jejunum, and tracheobronchial lymph nodes were largely replaced by the tumor tissues...
December 1999: Journal of Veterinary Medical Science
https://read.qxmd.com/read/10502451/ovine-placental-lactogen-and-human-growth-hormone-bind-to-different-regions-of-the-same-receptors
#31
COMPARATIVE STUDY
S A Longhi, C Wolfenstein-Todel, K A Gómez, M E Miranda, L A Retegui
Anti-human growth hormone (hGH) polyclonal and monoclonal antibodies (MAb) failed to recognize ovine placental lactogen (oPL), indicating that the antigenic topographies of both hormones are different. Binding assays showed that oPL completely inhibited hGH binding to lactogenic receptors from Nb2-cells and to somatogenic receptors from rabbit or sheep liver; in contrast, oPL only bound to a subpopulation of rat liver receptors. Zinc ion increased hGH and oPL binding to Nb2-cell receptors and slightly inhibited both hormones' recognition by somatogenic receptors...
June 1999: Growth Hormone & IGF Research
https://read.qxmd.com/read/10418823/cyno-ebv-ebv-related-herpesvirus-from-cynomolgus-macaques-induces-rabbit-malignant-lymphomas-and-their-tumor-cell-lines-frequently-show-specific-chromosomal-abnormalities
#32
JOURNAL ARTICLE
K Hayashi, H L Chen, H Yanai, T R Koirala, N Ohara, N Teramoto, T Oka, T Yoshino, K Takahashi, K Miyamoto, K Fujimoto, Y Yoshikawa, T Akagi
Malignant lymphoma (ML) induction in rabbits by Epstein-Barr virus (EBV)-related herpesvirus of cynomolgus (Cyno-EBV) is reported. Twenty-seven of 30 (90%) rabbits inoculated intravenously with Cyno-EBV-producing simian (cynomolgus) lymphocyte cell line (Ts-B6) cells developed ML between 45 and 115 days after inoculation. The peroral inoculation of Ts-B6 cells induced ML in only 2 of 10 (20%) rabbits (75 to 85 days). Five of 6 (83%) rabbits injected with cell-free pellets from Ts-B6 cultures also developed ML (27 to 122 days)...
July 1999: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://read.qxmd.com/read/10370802/the-incidence-of-malignancy-in-heart-transplant-recipients
#33
JOURNAL ARTICLE
M Garlicki, K Wierzbicki, P Przybyłowski, D Drop, M Biernat, P Rudziński, B Olszewska, A Dziatkowiak
OBJECTIVES AND METHODS: 219 heart transplant recipients with survival over 3 months were retro- and prospectively analysed for the incidence of primary neoplasms. Patients received immunosuppressive drugs (cyclosporine A, azathioprine, steroids) with a 4-5 days induction course of Rabbit Anti-Thymocyte Immunoglobulin (RATG) or monoclonal antibodies induction /OKT3/ in some cases. Anti-rejection treatment consisted of pulse doses of methyloprednisolon or RATG. RESULTS: 9 cases of malignancy (4...
1998: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/9849695/lymphoproliferative-disorders-following-allogeneic-bone-marrow-transplantation-the-vancouver-experience
#34
JOURNAL ARTICLE
I N Micallef, M Chhanabhai, R D Gascoyne, J D Shepherd, H C Fung, S H Nantel, C L Toze, H G Klingemann, H J Sutherland, D E Hogge, T J Nevill, A Le, M J Barnett
Between June 1988 and May 1996, 428 patients underwent allogeneic BMT (288 related donor (RD) and 140 unrelated donor (UD)) at the Vancouver General Hospital. Eight patients (UD six and RD two) developed a post-transplant lymphoproliferative disorder (PTLD). Median age at BMT was 38 years (range 22-51). Five of the six UD allografts were T cell depleted. Cyclosporine+/-methotrexate was used for GVHD prophylaxis. All eight patients developed GVHD; in six this was refractory to treatment with corticosteroids...
November 1998: Bone Marrow Transplantation
https://read.qxmd.com/read/9730252/prophylactic-effect-of-korean-mistletoe-viscum-album-coloratum-extract-on-tumor-metastasis-is-mediated-by-enhancement-of-nk-cell-activity
#35
JOURNAL ARTICLE
T J Yoon, Y C Yoo, T B Kang, Y J Baek, C S Huh, S K Song, K H Lee, I Azuma, J B Kim
We here demonstrated the prophylactic effect of an extract (KM-110) from Viscum album coloratum, a Korean mistletoe, on tumor metastasis produced by highly metastatic tumor cells, colon 26-M3.1 carcinoma, B16-BL6 melanoma and L5178Y-ML25 lymphoma cells, using experimental models in mice. Intravenous (i.v.) administration of KM-110 (100 microg/mouse) 2 days before tumor inoculation significantly inhibited lung metastasis of B16-BL6 and colon 26-M3.1 cells, and liver and spleen metastasis of L5178Y-ML25 cells...
April 1998: International Journal of Immunopharmacology
https://read.qxmd.com/read/9434859/thalidomide-lack-of-mutagenic-activity-across-phyla-and-genetic-endpoints
#36
JOURNAL ARTICLE
J Ashby, H Tinwell, R D Callander, I Kimber, P Clay, S M Galloway, R B Hill, S K Greenwood, M E Gaulden, M J Ferguson, E Vogel, M Nivard, J M Parry, J Williamson
The human and rabbit teratogen thalidomide has been tested for mutagenicity in a wide range of assays, ranging from bacterial gene mutation assays conducted in vitro to in vivo cytogenetic assays conducted using rabbits, and including a variety of human-derived tissues. Thalidomide was not mutagenic to 6 strains of Salmonella when tested both in the presence and absence of Aroclor-induced rat liver S9 mix. This inactivity was confirmed in strains TA98 and TA100 using a 1-h pre-incubation assay protocol with the same S9 mix (10% S9), and additionally, in strain TA98 using 3 concentrations of S9 (4%, 10% and 30% S9 in S9 mix)...
December 12, 1997: Mutation Research
https://read.qxmd.com/read/9322914/site-directed-mutagenesis-of-recombinant-bovine-placental-lactogen-at-lysine-73-leads-to-selective-attenuation-of-its-somatogenic-activity
#37
JOURNAL ARTICLE
D Helman, N R Staten, J Byatt, J Grosclaude, R E McKinnie, J Djiane, A Gertler
Bovine placental lactogen (bPL) is capable of binding and transducing biological activity via somatogenic and lactogenic receptors. To modify this capability, three analogs, bPL(K73D), bPL(K73F) and bPL(K73A), mutated at position 73, and corresponding to R64 in human GH (hGH), were produced in Escherichia coli. Circular dichroic spectrum analyses indicated proper refolding in all cases. Biological activity of these analogs was tested in vitro. In a lactogenic-receptor-mediated Nb2 rat lymphoma cell bioassay, bPL and its analogs acted similarly...
October 1997: Endocrinology
https://read.qxmd.com/read/9234382/malignant-lymphoma-induction-of-rabbits-with-oral-spray-of-epstein-barr-virus-related-herpesvirus-from-si-iia-cells-htlv-ii-transformed-cynomolgus-cell-line-a-possible-animal-model-for-epstein-barr-virus-infection-and-subsequent-virus-related-tumors-in-humans
#38
JOURNAL ARTICLE
T R Koirala, K Hayashi, H L Chen, H Ino, N Kariya, H Yanai, C R Choudhury, T Akagi
Malignant lymphoma (ML) was induced in eight of nine rabbits inoculated by oral spray of the cell-free pellets from Si-IIA culture (HTLV-II-transformed leukocyte cell line of the Cynomolgus-producing Epstein-Barr virus (EBV)-related herpesvirus) after 64-141 days. None of the rabbits inoculated with EBV from B-95-8 cells or HTLV-II from MOT cells developed ML. Malignant lymphomas were usually of diffuse, large-cell or mixed type. HTLV-II infection was excluded by the polymerase chain reaction (PCR) and the particle agglutination test...
July 1997: Pathology International
https://read.qxmd.com/read/9213332/metallothionein-a-potential-marker-for-differentiating-benign-and-neoplastic-gastrointestinal-lymphoid-infiltrates
#39
JOURNAL ARTICLE
K S Rizkalla, M G Cherian
Metallothioneins (MT) are low molecular weight, metal-binding proteins. The induction of MT synthesis by cytokines, hormones and other cytotoxic agents indicates its role in cellular proliferation and differentiation as well as in cellular defense mechanisms. Previous studies have detected expression of MT in various human tumors by immunohistochemical staining. In certain cases the presence of MT in a tumor may be associated with its resistance against radiation and chemotherapeutic agents. Immunohistochemical staining of MT using a rabbit polyclonal anti-rat liver MT antibody was carried out in eight gastric, two small bowel and one large bowel lymphomas, and in ten control gastrointestinal (gastric, colonic and small bowel) biopsies or excised bowel segments with benign lymphoid infiltrates...
May 1997: Pathology
https://read.qxmd.com/read/9178818/preventive-effect-of-igg-from-ebv-seropositive-donors-on-the-development-of-human-lympho-proliferative-disease-in-scid-mice
#40
JOURNAL ARTICLE
M R Abedi, A Linde, B Christensson, M Mackett, L Hammarström, C I Smith
The effect of weekly treatments with various gammaglobulin preparations on the development of human B-cell tumors was studied in severe combined immunodeficient (SCID) mice. SCID mice were injected i.p. with human peripheral blood mononuclear cells (PBMCs) from an Epstein-Barr virus (EBV)-seropositive healthy blood donor. Repopulated SCID mice were divided into 7 treatment groups receiving either PBS, 2 commercial gammaglobulin preparations, purified IgG prepared from pooled plasma from EBV-seronegative or -seropositive blood donors, a rabbit anti-serum against EBV envelope glycoprotein gp340 or interferon (IFN)-alpha...
May 16, 1997: International Journal of Cancer. Journal International du Cancer
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