J Ashby, H Tinwell, R D Callander, I Kimber, P Clay, S M Galloway, R B Hill, S K Greenwood, M E Gaulden, M J Ferguson, E Vogel, M Nivard, J M Parry, J Williamson
The human and rabbit teratogen thalidomide has been tested for mutagenicity in a wide range of assays, ranging from bacterial gene mutation assays conducted in vitro to in vivo cytogenetic assays conducted using rabbits, and including a variety of human-derived tissues. Thalidomide was not mutagenic to 6 strains of Salmonella when tested both in the presence and absence of Aroclor-induced rat liver S9 mix. This inactivity was confirmed in strains TA98 and TA100 using a 1-h pre-incubation assay protocol with the same S9 mix (10% S9), and additionally, in strain TA98 using 3 concentrations of S9 (4%, 10% and 30% S9 in S9 mix)...
December 12, 1997: Mutation Research