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Peter O’Sullivan

Darren John Beales, Odette Gaynor, Jasmine Harris, Robyn Fary, Peter Bruce O'Sullivan, Helen Slater, Thomas Graven-Nielsen, Thorvaldur Skuli Palsson
Background and aims For some women, lumbopelvic pain (LPP) developed during pregnancy becomes a continuing post-partum problem. Increased understanding of potential prognostic factors is required. This study investigated whether active straight leg raise (ASLR), sleep dysfunction and pressure pain sensitivity during pregnancy are correlated with LPP intensity and quality, disability, and physical health-related quality of life (HRQoL) post-partum. Methods An exploratory, prospective cohort study design was used...
October 11, 2018: Scandinavian Journal of Pain
Edward M Pascoe, Matthew Free, Peter S Mackie, Leo Donnan, Mark O'Sullivan, Michael J Sullivan, John A Heath
BACKGROUND: Osteosarcoma in children below the age of 5 is extremely rare. OBSERVATION: We report on a previously well 14-month-old male infant, who presented with a reluctance to weight-bear on his right leg and had an associated limp. Plain imaging and a magnetic resonance imaging scan demonstrated a lytic lesion in the right distal femur. An open surgical biopsy confirmed the diagnosis of osteosarcoma. There was no significant family history of cancer and genetic screening for Li-Fraumeni syndrome was negative...
October 9, 2018: Journal of Pediatric Hematology/oncology
Kieran O'Sullivan, Peter B O'Sullivan, Tim J Gabbett, Mary O'Keeffe
No abstract text is available yet for this article.
September 19, 2018: British Journal of Sports Medicine
Robert Waller, Anne Julia Smith, Peter Bruce O'Sullivan, Helen Slater, Michele Sterling, Leon Melville Straker
OBJECTIVES: To investigate the cross-sectional associations between musculoskeletal pain experience and measures of pressure and cold pain sensitivity in young adults from the Western Australian Pregnancy Cohort (Raine) Study. METHODS: PARTICIPANTS: (n=917) were eligible for analysis if they provided data pertaining to musculoskeletal pain status at the 22-year follow up and had data for at least one valid pain sensitivity test. Standardised protocols were used to assess pressure pain threshold (4 sites: lumbar spine, tibialis anterior, upper trapezius and wrist) and cold pain threshold (wrist)...
September 26, 2018: Clinical Journal of Pain
Siobhan McCarthy, Veronika Dvorakova, Peter O'Sullivan, John F Bourke
No abstract text is available yet for this article.
September 10, 2018: Contact Dermatitis
Alison M Thorpe, Peter B O'Sullivan, Tim Mitchell, Mark Hurworth, Jonathan Spencer, Grant Booth, Sven Goebel, Paul Khoo, Aaron Tay, Anne Smith
BACKGROUND: Psychologic factors are associated with pain and disability in patients with chronic shoulder pain. Recent research regarding the association of affective psychologic factors (emotions) with patients' pain and disability outcome after surgery disagrees; and the relationship between cognitive psychologic factors (thoughts and beliefs) and outcome after surgery is unknown. QUESTIONS/PURPOSES: (1) Are there identifiable clusters (based on psychologic functioning measures) in patients undergoing shoulder surgery? (2) Is poorer psychologic functioning associated with worse outcome (American Shoulder and Elbow Surgeons [ASES] score) after shoulder surgery? METHODS: This prospective cohort study investigated patients undergoing shoulder surgery for rotator cuff-related shoulder pain or rotator cuff tear by one of six surgeons between January 2014 and July 2015...
October 2018: Clinical Orthopaedics and related Research
Kieran O'Sullivan, Peter B O'Sullivan, Mary O'Keeffe
No abstract text is available yet for this article.
August 31, 2018: British Journal of Sports Medicine
Dylan Meng, Kieran O'Sullivan, Ben Darlow, Peter B O'Sullivan, Guri Ranum Ekås, Bruce B Forster
No abstract text is available yet for this article.
August 14, 2018: British Journal of Sports Medicine
Dylan E O'Sullivan, Troy W R Hillier, Darren R Brenner, Cheryl E Peters, Will D King
PURPOSE: Despite a strong association between indoor tanning and the risk of cutaneous cancers, the relationship between indoor tanning and non-cutaneous cancers is unknown. Our objective was to estimate the association of indoor tanning with developing non-cutaneous cancers. METHODS: We conducted a systematic literature review and meta-analysis of the association between indoor tanning and non-cutaneous cancer sites. Associations were estimated using random effects models...
August 11, 2018: Cancer Causes & Control: CCC
Zhong Jie Kua, Nancy A Pachana, Gerard J Byrne, John D O'Sullivan, Rodney Marsh, Elizabeth Torbey, Peter A Silburn, George D Mellick, Nadeeka N W Dissanayaka
Depression and anxiety are prevalent in Parkinson disease (PD) yet underrecognized in clinical practice. Caregiver reports are frequently utilized to aid in the assessment of neuropsychiatric symptoms but little is known about caregivers' ability to recognize them in patients with PD. This study sought to examine the accuracy of caregiver reports. Eighty patient-caregiver dyads were involved. Accuracy of caregiver recognition was assessed by examining the level of agreement between caregiver ratings on the Neuropsychiatric Inventory and patients' diagnosis of depression and anxiety on the Mini-International Neuropsychiatric Interview (MINI)-Plus...
September 2018: Journal of Geriatric Psychiatry and Neurology
Peter Chernoff, Comfort Adedokun, Iomhar O'Sullivan, John McManus, Ann Payne
BACKGROUND AND AIMS: Healthcare professionals are exposed to high levels of stress in the course of their profession and are particularly susceptible to experiencing burnout. In the USA, burnout among physicians is highly prevalent, exceeding that of other workers. Little literature has been published describing burnout prevalence in the context of the Irish emergency healthcare population. We conducted a survey to determine burnout in the Emergency Department hospital staff at Cork University Hospital (CUH)...
July 26, 2018: Irish Journal of Medical Science
Aoife M O'Connor, Brenda A McManus, Peter M Kinnevey, Gráinne I Brennan, Tanya E Fleming, Phillipa J Cashin, Michael O'Sullivan, Ioannis Polyzois, David C Coleman
Staphylococcus aureus and Staphylococcus epidermidis are frequent commensals of the nares and skin and are considered transient oral residents. Reports on their prevalence in the oral cavity, periodontal pockets and subgingivally around infected oral implants are conflicting, largely due to methodological limitations. The prevalence of these species in the oral cavities, periodontal pockets and subgingival sites of orally healthy individuals with/without implants and in patients with periodontal disease or infected implants (peri-implantitis) was investigated using selective chromogenic agar and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
2018: Frontiers in Microbiology
Danielle T Avery, Alisa Kane, Tina Nguyen, Anthony Lau, Akira Nguyen, Helen Lenthall, Kathryn Payne, Wei Shi, Henry Brigden, Elise French, Julia Bier, Jana R Hermes, David Zahra, William A Sewell, Danyal Butt, Michael Elliott, Kaan Boztug, Isabelle Meyts, Sharon Choo, Peter Hsu, Melanie Wong, Lucinda J Berglund, Paul Gray, Michael O'Sullivan, Theresa Cole, Steven M Holland, Cindy S Ma, Christoph Burkhart, Lynn M Corcoran, Tri Giang Phan, Robert Brink, Gulbu Uzel, Elissa K Deenick, Stuart G Tangye
Gain-of-function (GOF) mutations in PIK3CD , encoding the p110δ subunit of phosphatidylinositide 3-kinase (PI3K), cause a primary immunodeficiency. Affected individuals display impaired humoral immune responses following infection or immunization. To establish mechanisms underlying these immune defects, we studied a large cohort of patients with PIK3CD GOF mutations and established a novel mouse model using CRISPR/Cas9-mediated gene editing to introduce a common pathogenic mutation in Pik3cd In both species, hyperactive PI3K severely affected B cell development and differentiation in the bone marrow and the periphery...
August 6, 2018: Journal of Experimental Medicine
Frank Maixner, Dmitrij Turaev, Amaury Cazenave-Gassiot, Marek Janko, Ben Krause-Kyora, Michael R Hoopmann, Ulrike Kusebauch, Mark Sartain, Gea Guerriero, Niall O'Sullivan, Matthew Teasdale, Giovanna Cipollini, Alice Paladin, Valeria Mattiangeli, Marco Samadelli, Umberto Tecchiati, Andreas Putzer, Mine Palazoglu, John Meissen, Sandra Lösch, Philipp Rausch, John F Baines, Bum Jin Kim, Hyun-Joo An, Paul Gostner, Eduard Egarter-Vigl, Peter Malfertheiner, Andreas Keller, Robert W Stark, Markus Wenk, David Bishop, Daniel G Bradley, Oliver Fiehn, Lars Engstrand, Robert L Moritz, Philip Doble, Andre Franke, Almut Nebel, Klaus Oeggl, Thomas Rattei, Rudolf Grimm, Albert Zink
The history of humankind is marked by the constant adoption of new dietary habits affecting human physiology, metabolism, and even the development of nutrition-related disorders. Despite clear archaeological evidence for the shift from hunter-gatherer lifestyle to agriculture in Neolithic Europe [1], very little information exists on the daily dietary habits of our ancestors. By undertaking a complementary -omics approach combined with microscopy, we analyzed the stomach content of the Iceman, a 5,300-year-old European glacier mummy [2, 3]...
July 23, 2018: Current Biology: CB
J P Caneiro, Peter O'Sullivan, Ottmar V Lipp, Lara Mitchinson, Nicolai Oeveraas, Priyanka Bhalvani, Richard Abrugiato, Sean Thorkildsen, Anne Smith
Background and aims Despite lack of support from recent in vivo studies, bending and lifting (especially with a round-back posture) are perceived as dangerous to the back. In light of this view, it has been proposed that pain-free people may hold a common implicit belief that is congruent with the idea that bending and lifting with a round-back represents danger to a person's back, however this has not been evaluated. The aims of this study were: (1) to evaluate implicit associations between back posture and safety related to bending and lifting in pain-free people; (2) to explore correlations between the implicit measure and explicit measures of back beliefs, fear of movement and safety of bending; (3) to investigate self-reported qualitative appraisal of safe lifting...
October 25, 2018: Scandinavian Journal of Pain
Jeremy Lewis, Peter O'Sullivan
No abstract text is available yet for this article.
June 25, 2018: British Journal of Sports Medicine
Robert Waller, Leon Straker, Peter O'Sullivan, Michele Sterling, Anne Smith
Background and aims Investigation of the multidimensional correlates of pressure pain threshold (PPT) requires the study of large cohorts, and thus the use of multiple raters, for sufficient statistical power. Although PPT testing has previously been shown to be reliable, the reliability of multiple raters and investigation for systematic bias between raters has not been reported. The aim of this study was to evaluate the intrarater and interrater reliability of PPT measurement by handheld algometer at the wrist, leg, cervical spine and lumbar spine...
October 1, 2015: Scandinavian Journal of Pain
Gemma D Banham, Shaun M Flint, Nicholas Torpey, Paul A Lyons, Don N Shanahan, Adele Gibson, Christopher J E Watson, Ann-Marie O'Sullivan, Joseph A Chadwick, Katie E Foster, Rachel B Jones, Luke R Devey, Anna Richards, Lars-Peter Erwig, Caroline O Savage, Kenneth G C Smith, Robert B Henderson, Menna R Clatworthy
BACKGROUND: B cells produce alloantibodies and activate alloreactive T cells, negatively affecting kidney transplant survival. By contrast, regulatory B cells are associated with transplant tolerance. Immunotherapies are needed that inhibit B-cell effector function, including antibody secretion, while sparing regulators and minimising infection risk. B lymphocyte stimulator (BLyS) is a cytokine that promotes B-cell activation and has not previously been targeted in kidney transplant recipients...
June 30, 2018: Lancet
Gilad Horowitz, Ali Hosni, Eugene Yu, Wei Xu, Lin Lu, Michael Au, Peter R Dixon, Dale Brown, Douglas B Chepeha, Ralph W Gilbert, David P Goldstein, Patrick J Gullane, Jonathan C Irish, Andrew Bayley, John Cho, Meredith Giuliani, Shao Hui Huang, Andrew Hope, John Kim, Brian O'Sullivan, Jolie Ringash, John Waldron, Ilan Weinreb, Bayardo Perez-Ordonez, Scott V Bratman, John R de Almeida
OBJECTIVE: (1) To estimate the prevalence of radiographically positive Retro-Pharyngeal Lymph Nodes (RPLN) in unknown primary carcinoma of the head and neck and (2) to determine the prognostic implications of radiographically positive RPLN and other radiographic features (3) to identify patients at low risk for retropharyngeal metastasis. MATERIALS AND METHODS: The medical records of all 68 eligible patients treated at the Princess Margaret Cancer Centre between 2000 and 2014 were retrospectively reviewed for demographic, clinical, pathologic, and radiologic data...
July 2018: Oral Oncology
Pieter Coenen, Anne Smith, Peter Kent, Mark Harris, Steven J Linton, Glenn Pransky, Darren Beales, Peter O'Sullivan, Leon Straker
Objectives Spinal (ie, back and neck) pain often develops as early as during adolescence and can set a trajectory for later life. However, whether early-life spinal-pain-related behavioral responses of missing school/work are predictive of future work absenteeism is yet unknown. We assessed the association of adolescent spinal-pain-related work or school absenteeism with early adulthood work absenteeism in a prospective population-based cohort. Methods Six year follow-up data from the Western Australian Pregnancy Cohort (Raine) study were used (N=476; with a 54% response rate)...
September 1, 2018: Scandinavian Journal of Work, Environment & Health
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