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Peter O’Sullivan

Dylan Meng, Kieran O'Sullivan, Ben Darlow, Peter B O'Sullivan, Guri Ranum Ekås, Bruce B Forster
No abstract text is available yet for this article.
August 14, 2018: British Journal of Sports Medicine
Dylan E O'Sullivan, Troy W R Hillier, Darren R Brenner, Cheryl E Peters, Will D King
PURPOSE: Despite a strong association between indoor tanning and the risk of cutaneous cancers, the relationship between indoor tanning and non-cutaneous cancers is unknown. Our objective was to estimate the association of indoor tanning with developing non-cutaneous cancers. METHODS: We conducted a systematic literature review and meta-analysis of the association between indoor tanning and non-cutaneous cancer sites. Associations were estimated using random effects models...
August 11, 2018: Cancer Causes & Control: CCC
Zhong Jie Kua, Nancy A Pachana, Gerard J Byrne, John D O'Sullivan, Marsh Rodney, Elizabeth Torbey, Peter A Silburn, George D Mellick, Nadeeka N W Dissanayaka
Depression and anxiety are prevalent in Parkinson disease (PD) yet underrecognized in clinical practice. Caregiver reports are frequently utilized to aid in the assessment of neuropsychiatric symptoms but little is known about caregivers' ability to recognize them in patients with PD. This study sought to examine the accuracy of caregiver reports. Eighty patient-caregiver dyads were involved. Accuracy of caregiver recognition was assessed by examining the level of agreement between caregiver ratings on the Neuropsychiatric Inventory and patients' diagnosis of depression and anxiety on the Mini-International Neuropsychiatric Interview (MINI)-Plus...
August 2, 2018: Journal of Geriatric Psychiatry and Neurology
Peter Chernoff, Comfort Adedokun, Iomhar O'Sullivan, John McManus, Ann Payne
BACKGROUND AND AIMS: Healthcare professionals are exposed to high levels of stress in the course of their profession and are particularly susceptible to experiencing burnout. In the USA, burnout among physicians is highly prevalent, exceeding that of other workers. Little literature has been published describing burnout prevalence in the context of the Irish emergency healthcare population. We conducted a survey to determine burnout in the Emergency Department hospital staff at Cork University Hospital (CUH)...
July 26, 2018: Irish Journal of Medical Science
Aoife M O'Connor, Brenda A McManus, Peter M Kinnevey, Gráinne I Brennan, Tanya E Fleming, Phillipa J Cashin, Michael O'Sullivan, Ioannis Polyzois, David C Coleman
Staphylococcus aureus and Staphylococcus epidermidis are frequent commensals of the nares and skin and are considered transient oral residents. Reports on their prevalence in the oral cavity, periodontal pockets and subgingivally around infected oral implants are conflicting, largely due to methodological limitations. The prevalence of these species in the oral cavities, periodontal pockets and subgingival sites of orally healthy individuals with/without implants and in patients with periodontal disease or infected implants (peri-implantitis) was investigated using selective chromogenic agar and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
2018: Frontiers in Microbiology
Danielle T Avery, Alisa Kane, Tina Nguyen, Anthony Lau, Akira Nguyen, Helen Lenthall, Kathryn Payne, Wei Shi, Henry Brigden, Elise French, Julia Bier, Jana R Hermes, David Zahra, William A Sewell, Danyal Butt, Michael Elliott, Kaan Boztug, Isabelle Meyts, Sharon Choo, Peter Hsu, Melanie Wong, Lucinda J Berglund, Paul Gray, Michael O'Sullivan, Theresa Cole, Steven M Holland, Cindy S Ma, Christoph Burkhart, Lynn M Corcoran, Tri Giang Phan, Robert Brink, Gulbu Uzel, Elissa K Deenick, Stuart G Tangye
Gain-of-function (GOF) mutations in PIK3CD , encoding the p110δ subunit of phosphatidylinositide 3-kinase (PI3K), cause a primary immunodeficiency. Affected individuals display impaired humoral immune responses following infection or immunization. To establish mechanisms underlying these immune defects, we studied a large cohort of patients with PIK3CD GOF mutations and established a novel mouse model using CRISPR/Cas9-mediated gene editing to introduce a common pathogenic mutation in Pik3cd In both species, hyperactive PI3K severely affected B cell development and differentiation in the bone marrow and the periphery...
August 6, 2018: Journal of Experimental Medicine
Frank Maixner, Dmitrij Turaev, Amaury Cazenave-Gassiot, Marek Janko, Ben Krause-Kyora, Michael R Hoopmann, Ulrike Kusebauch, Mark Sartain, Gea Guerriero, Niall O'Sullivan, Matthew Teasdale, Giovanna Cipollini, Alice Paladin, Valeria Mattiangeli, Marco Samadelli, Umberto Tecchiati, Andreas Putzer, Mine Palazoglu, John Meissen, Sandra Lösch, Philipp Rausch, John F Baines, Bum Jin Kim, Hyun-Joo An, Paul Gostner, Eduard Egarter-Vigl, Peter Malfertheiner, Andreas Keller, Robert W Stark, Markus Wenk, David Bishop, Daniel G Bradley, Oliver Fiehn, Lars Engstrand, Robert L Moritz, Philip Doble, Andre Franke, Almut Nebel, Klaus Oeggl, Thomas Rattei, Rudolf Grimm, Albert Zink
The history of humankind is marked by the constant adoption of new dietary habits affecting human physiology, metabolism, and even the development of nutrition-related disorders. Despite clear archaeological evidence for the shift from hunter-gatherer lifestyle to agriculture in Neolithic Europe [1], very little information exists on the daily dietary habits of our ancestors. By undertaking a complementary -omics approach combined with microscopy, we analyzed the stomach content of the Iceman, a 5,300-year-old European glacier mummy [2, 3]...
July 23, 2018: Current Biology: CB
J P Caneiro, Peter O'Sullivan, Ottmar V Lipp, Lara Mitchinson, Nicolai Oeveraas, Priyanka Bhalvani, Richard Abrugiato, Sean Thorkildsen, Anne Smith
BACKGROUND AND AIMS: Despite lack of support from recent in vivo studies, bending and lifting (especially with a round-back posture) are perceived as dangerous to the back. In light of this view, it has been proposed that pain-free people may hold a common implicit belief that is congruent with the idea that bending and lifting with a round-back represents danger to a person's back, however this has not been evaluated. The aims of this study were: (1) to evaluate implicit associations between back posture and safety related to bending and lifting in pain-free people; (2) to explore correlations between the implicit measure and explicit measures of back beliefs, fear of movement and safety of bending; (3) to investigate self-reported qualitative appraisal of safe lifting...
July 9, 2018: Scandinavian Journal of Pain
Jeremy Lewis, Peter O'Sullivan
No abstract text is available yet for this article.
June 25, 2018: British Journal of Sports Medicine
Robert Waller, Leon Straker, Peter O'Sullivan, Michele Sterling, Anne Smith
Background and aims Investigation of the multidimensional correlates of pressure pain threshold (PPT) requires the study of large cohorts, and thus the use of multiple raters, for sufficient statistical power. Although PPT testing has previously been shown to be reliable, the reliability of multiple raters and investigation for systematic bias between raters has not been reported. The aim of this study was to evaluate the intrarater and interrater reliability of PPT measurement by handheld algometer at the wrist, leg, cervical spine and lumbar spine...
October 1, 2015: Scandinavian Journal of Pain
Gemma D Banham, Shaun M Flint, Nicholas Torpey, Paul A Lyons, Don N Shanahan, Adele Gibson, Christopher J E Watson, Ann-Marie O'Sullivan, Joseph A Chadwick, Katie E Foster, Rachel B Jones, Luke R Devey, Anna Richards, Lars-Peter Erwig, Caroline O Savage, Kenneth G C Smith, Robert B Henderson, Menna R Clatworthy
BACKGROUND: B cells produce alloantibodies and activate alloreactive T cells, negatively affecting kidney transplant survival. By contrast, regulatory B cells are associated with transplant tolerance. Immunotherapies are needed that inhibit B-cell effector function, including antibody secretion, while sparing regulators and minimising infection risk. B lymphocyte stimulator (BLyS) is a cytokine that promotes B-cell activation and has not previously been targeted in kidney transplant recipients...
June 30, 2018: Lancet
Gilad Horowitz, Ali Hosni, Eugene Yu, Wei Xu, Lin Lu, Michael Au, Peter R Dixon, Dale Brown, Douglas B Chepeha, Ralph W Gilbert, David P Goldstein, Patrick J Gullane, Jonathan C Irish, Andrew Bayley, John Cho, Meredith Giuliani, Shao Hui Huang, Andrew Hope, John Kim, Brian O'Sullivan, Jolie Ringash, John Waldron, Ilan Weinreb, Bayardo Perez-Ordonez, Scott V Bratman, John R de Almeida
OBJECTIVE: (1) To estimate the prevalence of radiographically positive Retro-Pharyngeal Lymph Nodes (RPLN) in unknown primary carcinoma of the head and neck and (2) to determine the prognostic implications of radiographically positive RPLN and other radiographic features (3) to identify patients at low risk for retropharyngeal metastasis. MATERIALS AND METHODS: The medical records of all 68 eligible patients treated at the Princess Margaret Cancer Centre between 2000 and 2014 were retrospectively reviewed for demographic, clinical, pathologic, and radiologic data...
July 2018: Oral Oncology
Pieter Coenen, Anne Smith, Peter Kent, Mark Harris, Steven J Linton, Glenn Pransky, Darren Beales, Peter O'Sullivan, Leon Straker
Objectives Spinal (ie, back and neck) pain often develops as early as during adolescence and can set a trajectory for later life. However, whether early-life spinal-pain-related behavioral responses of missing school/work are predictive of future work absenteeism is yet unknown. We assessed the association of adolescent spinal-pain-related work or school absenteeism with early adulthood work absenteeism in a prospective population-based cohort. Methods Six year follow-up data from the Western Australian Pregnancy Cohort (Raine) study were used (N=476; with a 54% response rate)...
June 11, 2018: Scandinavian Journal of Work, Environment & Health
Xuezhi Jiang, Ragad Asmaro, David M O'Sullivan, Jaymin Modi, Elizabeth Budnik, Peter F Schnatz
OBJECTIVE: Depression has been suggested as a risk factor for coronary heart disease (CHD). However, whether the risk may be affected by age is unknown. We seek to assess the difference in long-term CHD risk between younger (<65) and older (≥65) women with depressive symptoms. METHODS: Between June and August 2004, 1995 women presenting for routine mammography were enrolled to the primary study on breast arterial calcification. In 2005 (year 2), each woman completed a validated depression screening questionnaire...
May 24, 2018: International Journal of Cardiology
Kenneth R Gundle, Anthony M Griffin, Brendan C Dickson, Peter W Chung, Charles N Catton, Brian O'Sullivan, Jay S Wunder, Peter C Ferguson
No abstract text is available yet for this article.
August 1, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Seán Mc Auliffe, Rodney Whiteley, Peter Malliaras, Kieran O'Sullivan
No abstract text is available yet for this article.
May 30, 2018: British Journal of Sports Medicine
Emily S J Edwards, Julia Bier, Theresa S Cole, Melanie Wong, Peter Hsu, Lucinda J Berglund, Kaan Boztug, Anthony Lau, Emma Gostick, David A Price, Michael O'Sullivan, Isabelle Meyts, Sharon Choo, Paul Gray, Steven M Holland, Elissa K Deenick, Gulbu Uzel, Stuart G Tangye
BACKGROUND: Germline gain-of function (GOF) mutations in PIK3CD, encoding the catalytic p110δ subunit of phosphoinositide 3-kinase (PI3K), result in hyperactivation of the PI3K-AKT-mechanistic target of rapamycin pathway and underlie a novel inborn error of immunity. Affected subjects exhibit perturbed humoral and cellular immunity, manifesting as recurrent infections, autoimmunity, hepatosplenomegaly, uncontrolled EBV and/or cytomegalovirus infection, and increased incidence of B-cell lymphoproliferation, lymphoma, or both...
May 22, 2018: Journal of Allergy and Clinical Immunology
Anneliese Synnot, Peter Bragge, Dianne Lowe, Jack S Nunn, Molly O'Sullivan, Lidia Horvat, Allison Tong, Debra Kay, Davina Ghersi, Steve McDonald, Naomi Poole, Noni Bourke, Natasha Lannin, Danny Vadasz, Sandy Oliver, Karen Carey, Sophie J Hill
OBJECTIVE: To identify research priorities of consumers and other stakeholders to inform Cochrane Reviews in 'health communication and participation' (including such concepts as patient experience, shared decision-making and health literacy). SETTING: International. PARTICIPANTS: We included anyone with an interest in health communication and participation. Up to 151 participants (18-80 years; 117 female) across 12 countries took part, including 48 consumers (patients, carers, consumer representatives) and 75 professionals (health professionals, policymakers, researchers) (plus 25 people who identified as both)...
May 8, 2018: BMJ Open
Owen Cronin, Wiley Barton, Peter Skuse, Nicholas C Penney, Isabel Garcia-Perez, Eileen F Murphy, Trevor Woods, Helena Nugent, Aine Fanning, Silvia Melgar, Eanna C Falvey, Elaine Holmes, Paul D Cotter, Orla O'Sullivan, Michael G Molloy, Fergus Shanahan
Many components of modern living exert influence on the resident intestinal microbiota of humans with resultant impact on host health. For example, exercise-associated changes in the diversity, composition, and functional profiles of microbial populations in the gut have been described in cross-sectional studies of habitual athletes. However, this relationship is also affected by changes in diet, such as changes in dietary and supplementary protein consumption, that coincide with exercise. To determine whether increasing physical activity and/or increased protein intake modulates gut microbial composition and function, we prospectively challenged healthy but sedentary adults with a short-term exercise regime, with and without concurrent daily whey protein consumption...
May 2018: MSystems
Peter B O'Sullivan, J P Caneiro, Mary O'Keeffe, Anne Smith, Wim Dankaerts, Kjartan Fersum, Kieran O'Sullivan
Biomedical approaches for diagnosing and managing disabling low back pain (LBP) have failed to arrest the exponential increase in health care costs, with a concurrent increase in disability and chronicity. Health messages regarding the vulnerability of the spine and a failure to target the interplay among multiple factors that contribute to pain and disability may partly explain this situation. Although many approaches and subgrouping systems for disabling LBP have been proposed in an attempt to deal with this complexity, they have been criticized for being unidimensional and reductionist and for not improving outcomes...
May 1, 2018: Physical Therapy
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