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Peter O’Sullivan

Vasileios Korakakis, Kieran O'Sullivan, Peter B O'Sullivan, Vasiliki Evagelinou, Yiannis Sotiralis, Alexandros Sideris, Konstantinos Sakellariou, Stefanos Karanasios, Giannis Giakas
BACKGROUND: Assessment of, and advice about, spinal posture is common when people with spinal pain present to physiotherapists. Most descriptions regarding optimal spinal posture have been qualitative in nature. OBJECTIVES: To determine the beliefs of physiotherapists regarding optimal sitting and standing posture. DESIGN: Online survey. METHOD: 544 Greek physiotherapists selected an optimal sitting (choice of seven) and standing (choice of five) posture, while providing justification for their choice...
November 17, 2018: Musculoskeletal Science & Practice
Ian Cowell, Peter O'Sullivan, Kieran O'Sullivan, Ross Poyton, Alison McGregor, Ged Murtagh
BACKGROUND: It has long been acknowledged that nonspecific chronic low back pain (NSCLBP) is associated with a complex combination of biopsychosocial (BPS) factors, and recent guidelines advocate that the management of back pain should reflect this multidimensional complexity. Cognitive functional therapy (CFT) is a behaviourally oriented intervention that targets patients' individual BPS profiles. Although the efficacy of CFT has been demonstrated in primary care, little evidence exists about the training requirements of this approach...
November 23, 2018: Musculoskeletal Care
Boaz Shulruf, Barbara-Ann Adelstein, Arvin Damodaran, Peter Harris, Sean Kennedy, Anthony O'Sullivan, Silas Taylor
BACKGROUND: Objective Structured Clinical Exams are used to increase reliability and validity, yet they only achieve a modest level of reliability. This low reliability is due in part to examiner variance which is greater than the variance of students. This variance often represents indecisiveness at the cut score with apparent confusion over terms such as "borderline pass". It is amplified by a well reported failure to fail. METHODS: A borderline grade (meaning performance is neither a clear pass nor a clear fail) was introduced in a high stakes undergraduate medical clinical skills exam to replace a borderline pass grade (which was historically resolved as 50%) in a 4 point scale (distinction, pass, borderline, fail)...
November 20, 2018: BMC Medical Education
Ian Cowell, Peter O'Sullivan, Kieran O'Sullivan, Ross Poyton, Alison McGregor, Ged Murtagh
BACKGROUND: Physiotherapists have been urged to embrace a patient-oriented biopsychosocial (BPS) framework for the management of non-specific chronic low back pain (NSCLBP). However, recent evidence suggests that providing broader BPS interventions demonstrates small differences in pain or disability compared to usual care. Little is known about how to integrate a BPS model into physiotherapy practice and the challenges it presents. OBJECTIVE: To explore the perceptions of physiotherapists' in primary care in England adopting a BPS approach to managing NSCLBP patients...
December 2018: Musculoskeletal Science & Practice
Jeffrey M Cochran, David R Busch, Anaïs Leproux, Zheng Zhang, Thomas D O'Sullivan, Albert E Cerussi, Philip M Carpenter, Rita S Mehta, Darren Roblyer, Wei Yang, Keith D Paulsen, Brian Pogue, Shudong Jiang, Peter A Kaufman, So Hyun Chung, Mitchell Schnall, Bradley S Snyder, Nola Hylton, Stefan A Carp, Steven J Isakoff, David Mankoff, Bruce J Tromberg, Arjun G Yodh
Ideally, neoadjuvant chemotherapy (NAC) assessment should predict pathologic complete response (pCR), a surrogate clinical endpoint for 5-year survival, as early as possible during typical 3- to 6-month breast cancer treatments. We introduce and demonstrate an approach for predicting pCR within 10 days of initiating NAC. The method uses a bedside diffuse optical spectroscopic imaging (DOSI) technology and logistic regression modeling. Tumor and normal tissue physiological properties were measured longitudinally throughout the course of NAC in 33 patients enrolled in the American College of Radiology Imaging Network multicenter breast cancer DOSI trial (ACRIN-6691)...
October 2018: Journal of Biomedical Optics
Darren John Beales, Odette Gaynor, Jasmine Harris, Robyn Fary, Peter Bruce O'Sullivan, Helen Slater, Thomas Graven-Nielsen, Thorvaldur Skuli Palsson
Background and aims For some women, lumbopelvic pain (LPP) developed during pregnancy becomes a continuing post-partum problem. Increased understanding of potential prognostic factors is required. This study investigated whether active straight leg raise (ASLR), sleep dysfunction and pressure pain sensitivity during pregnancy are correlated with LPP intensity and quality, disability, and physical health-related quality of life (HRQoL) post-partum. Methods An exploratory, prospective cohort study design was used...
October 11, 2018: Scandinavian Journal of Pain
Edward M Pascoe, Matthew Free, Peter S Mackie, Leo Donnan, Mark O'Sullivan, Michael J Sullivan, John A Heath
BACKGROUND: Osteosarcoma in children below the age of 5 is extremely rare. OBSERVATION: We report on a previously well 14-month-old male infant, who presented with a reluctance to weight-bear on his right leg and had an associated limp. Plain imaging and a magnetic resonance imaging scan demonstrated a lytic lesion in the right distal femur. An open surgical biopsy confirmed the diagnosis of osteosarcoma. There was no significant family history of cancer and genetic screening for Li-Fraumeni syndrome was negative...
October 9, 2018: Journal of Pediatric Hematology/oncology
Kieran O'Sullivan, Peter B O'Sullivan, Tim J Gabbett, Mary O'Keeffe
No abstract text is available yet for this article.
September 19, 2018: British Journal of Sports Medicine
Robert Waller, Anne Julia Smith, Peter Bruce O'Sullivan, Helen Slater, Michele Sterling, Leon Melville Straker
OBJECTIVES: To investigate the cross-sectional associations between musculoskeletal pain experience and measures of pressure and cold pain sensitivity in young adults from the Western Australian Pregnancy Cohort (Raine) Study. METHODS: PARTICIPANTS: (n=917) were eligible for analysis if they provided data pertaining to musculoskeletal pain status at the 22-year follow up and had data for at least one valid pain sensitivity test. Standardised protocols were used to assess pressure pain threshold (4 sites: lumbar spine, tibialis anterior, upper trapezius and wrist) and cold pain threshold (wrist)...
September 26, 2018: Clinical Journal of Pain
Siobhan McCarthy, Veronika Dvorakova, Peter O'Sullivan, John F Bourke
No abstract text is available yet for this article.
September 10, 2018: Contact Dermatitis
Alison M Thorpe, Peter B O'Sullivan, Tim Mitchell, Mark Hurworth, Jonathan Spencer, Grant Booth, Sven Goebel, Paul Khoo, Aaron Tay, Anne Smith
BACKGROUND: Psychologic factors are associated with pain and disability in patients with chronic shoulder pain. Recent research regarding the association of affective psychologic factors (emotions) with patients' pain and disability outcome after surgery disagrees; and the relationship between cognitive psychologic factors (thoughts and beliefs) and outcome after surgery is unknown. QUESTIONS/PURPOSES: (1) Are there identifiable clusters (based on psychologic functioning measures) in patients undergoing shoulder surgery? (2) Is poorer psychologic functioning associated with worse outcome (American Shoulder and Elbow Surgeons [ASES] score) after shoulder surgery? METHODS: This prospective cohort study investigated patients undergoing shoulder surgery for rotator cuff-related shoulder pain or rotator cuff tear by one of six surgeons between January 2014 and July 2015...
October 2018: Clinical Orthopaedics and related Research
Kieran O'Sullivan, Peter B O'Sullivan, Mary O'Keeffe
No abstract text is available yet for this article.
August 31, 2018: British Journal of Sports Medicine
Dylan Meng, Kieran O'Sullivan, Ben Darlow, Peter B O'Sullivan, Guri Ranum Ekås, Bruce B Forster
No abstract text is available yet for this article.
August 14, 2018: British Journal of Sports Medicine
Dylan E O'Sullivan, Troy W R Hillier, Darren R Brenner, Cheryl E Peters, Will D King
PURPOSE: Despite a strong association between indoor tanning and the risk of cutaneous cancers, the relationship between indoor tanning and non-cutaneous cancers is unknown. Our objective was to estimate the association of indoor tanning with developing non-cutaneous cancers. METHODS: We conducted a systematic literature review and meta-analysis of the association between indoor tanning and non-cutaneous cancer sites. Associations were estimated using random effects models...
October 2018: Cancer Causes & Control: CCC
Zhong Jie Kua, Nancy A Pachana, Gerard J Byrne, John D O'Sullivan, Rodney Marsh, Elizabeth Torbey, Peter A Silburn, George D Mellick, Nadeeka N W Dissanayaka
Depression and anxiety are prevalent in Parkinson disease (PD) yet underrecognized in clinical practice. Caregiver reports are frequently utilized to aid in the assessment of neuropsychiatric symptoms but little is known about caregivers' ability to recognize them in patients with PD. This study sought to examine the accuracy of caregiver reports. Eighty patient-caregiver dyads were involved. Accuracy of caregiver recognition was assessed by examining the level of agreement between caregiver ratings on the Neuropsychiatric Inventory and patients' diagnosis of depression and anxiety on the Mini-International Neuropsychiatric Interview (MINI)-Plus...
September 2018: Journal of Geriatric Psychiatry and Neurology
Peter Chernoff, Comfort Adedokun, Iomhar O'Sullivan, John McManus, Ann Payne
BACKGROUND AND AIMS: Healthcare professionals are exposed to high levels of stress in the course of their profession and are particularly susceptible to experiencing burnout. In the USA, burnout among physicians is highly prevalent, exceeding that of other workers. Little literature has been published describing burnout prevalence in the context of the Irish emergency healthcare population. We conducted a survey to determine burnout in the Emergency Department hospital staff at Cork University Hospital (CUH)...
July 26, 2018: Irish Journal of Medical Science
Aoife M O'Connor, Brenda A McManus, Peter M Kinnevey, Gráinne I Brennan, Tanya E Fleming, Phillipa J Cashin, Michael O'Sullivan, Ioannis Polyzois, David C Coleman
Staphylococcus aureus and Staphylococcus epidermidis are frequent commensals of the nares and skin and are considered transient oral residents. Reports on their prevalence in the oral cavity, periodontal pockets and subgingivally around infected oral implants are conflicting, largely due to methodological limitations. The prevalence of these species in the oral cavities, periodontal pockets and subgingival sites of orally healthy individuals with/without implants and in patients with periodontal disease or infected implants (peri-implantitis) was investigated using selective chromogenic agar and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
2018: Frontiers in Microbiology
Danielle T Avery, Alisa Kane, Tina Nguyen, Anthony Lau, Akira Nguyen, Helen Lenthall, Kathryn Payne, Wei Shi, Henry Brigden, Elise French, Julia Bier, Jana R Hermes, David Zahra, William A Sewell, Danyal Butt, Michael Elliott, Kaan Boztug, Isabelle Meyts, Sharon Choo, Peter Hsu, Melanie Wong, Lucinda J Berglund, Paul Gray, Michael O'Sullivan, Theresa Cole, Steven M Holland, Cindy S Ma, Christoph Burkhart, Lynn M Corcoran, Tri Giang Phan, Robert Brink, Gulbu Uzel, Elissa K Deenick, Stuart G Tangye
Gain-of-function (GOF) mutations in PIK3CD , encoding the p110δ subunit of phosphatidylinositide 3-kinase (PI3K), cause a primary immunodeficiency. Affected individuals display impaired humoral immune responses following infection or immunization. To establish mechanisms underlying these immune defects, we studied a large cohort of patients with PIK3CD GOF mutations and established a novel mouse model using CRISPR/Cas9-mediated gene editing to introduce a common pathogenic mutation in Pik3cd In both species, hyperactive PI3K severely affected B cell development and differentiation in the bone marrow and the periphery...
August 6, 2018: Journal of Experimental Medicine
Frank Maixner, Dmitrij Turaev, Amaury Cazenave-Gassiot, Marek Janko, Ben Krause-Kyora, Michael R Hoopmann, Ulrike Kusebauch, Mark Sartain, Gea Guerriero, Niall O'Sullivan, Matthew Teasdale, Giovanna Cipollini, Alice Paladin, Valeria Mattiangeli, Marco Samadelli, Umberto Tecchiati, Andreas Putzer, Mine Palazoglu, John Meissen, Sandra Lösch, Philipp Rausch, John F Baines, Bum Jin Kim, Hyun-Joo An, Paul Gostner, Eduard Egarter-Vigl, Peter Malfertheiner, Andreas Keller, Robert W Stark, Markus Wenk, David Bishop, Daniel G Bradley, Oliver Fiehn, Lars Engstrand, Robert L Moritz, Philip Doble, Andre Franke, Almut Nebel, Klaus Oeggl, Thomas Rattei, Rudolf Grimm, Albert Zink
The history of humankind is marked by the constant adoption of new dietary habits affecting human physiology, metabolism, and even the development of nutrition-related disorders. Despite clear archaeological evidence for the shift from hunter-gatherer lifestyle to agriculture in Neolithic Europe [1], very little information exists on the daily dietary habits of our ancestors. By undertaking a complementary -omics approach combined with microscopy, we analyzed the stomach content of the Iceman, a 5,300-year-old European glacier mummy [2, 3]...
July 23, 2018: Current Biology: CB
J P Caneiro, Peter O'Sullivan, Ottmar V Lipp, Lara Mitchinson, Nicolai Oeveraas, Priyanka Bhalvani, Richard Abrugiato, Sean Thorkildsen, Anne Smith
Background and aims Despite lack of support from recent in vivo studies, bending and lifting (especially with a round-back posture) are perceived as dangerous to the back. In light of this view, it has been proposed that pain-free people may hold a common implicit belief that is congruent with the idea that bending and lifting with a round-back represents danger to a person's back, however this has not been evaluated. The aims of this study were: (1) to evaluate implicit associations between back posture and safety related to bending and lifting in pain-free people; (2) to explore correlations between the implicit measure and explicit measures of back beliefs, fear of movement and safety of bending; (3) to investigate self-reported qualitative appraisal of safe lifting...
October 25, 2018: Scandinavian Journal of Pain
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