keyword
https://read.qxmd.com/read/33115341/does-movement-change-when-low-back-pain-changes-a-systematic-review
#1
JOURNAL ARTICLE
Kevin Wernli, Jay-Shian Tan, Peter O'Sullivan, Anne Smith, Amity Campbell, Peter Kent
OBJECTIVE: To investigate the relationship between changes in volitional spinal movement (including muscle activity) and changes in pain or activity limitation at the individual level in people with nonspecific low back pain. DESIGN: Etiology systematic review. LITERATURE SEARCH: MEDLINE, Embase, CINAHL, and AMED were searched from inception to January 2020. STUDY SELECTION CRITERIA: The study included peer-reviewed articles that reported the relationship between changes in volitional spinal movement and changes in pain or activity limitation at the individual level in people with nonspecific low back pain...
December 2020: Journal of Orthopaedic and Sports Physical Therapy
https://read.qxmd.com/read/33109334/how-covid-19-inspired-surgical-residents-to-rethink-educational-programs
#2
EDITORIAL
Riley Brian, Peter Stock, Shareef Syed, Kenzo Hirose, Linda Reilly, Patricia O'Sullivan
No abstract text is available yet for this article.
October 21, 2020: American Journal of Surgery
https://read.qxmd.com/read/33097591/itaconate-controls-the-severity-of-pulmonary-fibrosis
#3
JOURNAL ARTICLE
Patricia P Ogger, Gesa J Albers, Richard J Hewitt, Brendan J O'Sullivan, Joseph E Powell, Emily Calamita, Poonam Ghai, Simone A Walker, Peter McErlean, Peter Saunders, Shaun Kingston, Philip L Molyneaux, John M Halket, Robert Gray, Daniel C Chambers, Toby M Maher, Clare M Lloyd, Adam J Byrne
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease in which airway macrophages (AMs) play a key role. Itaconate has emerged as a mediator of macrophage function, but its role during fibrosis is unknown. Here, we reveal that itaconate is an endogenous antifibrotic factor in the lung. Itaconate levels are reduced in bronchoalveolar lavage, and itaconate-synthesizing cis-aconitate decarboxylase expression ( ACOD1 ) is reduced in AMs from patients with IPF compared with controls. In the murine bleomycin model of pulmonary fibrosis, Acod1-/- mice develop persistent fibrosis, unlike wild-type (WT) littermates...
October 23, 2020: Science Immunology
https://read.qxmd.com/read/33036997/-you-re-the-best-liar-in-the-world-a-grounded-theory-study-of-rowing-athletes-experience-of-low-back-pain
#4
JOURNAL ARTICLE
Fiona Wilson, Leo Ng, Kieran O'Sullivan, J P Caneiro, Peter Pb O'Sullivan, Alex Horgan, Jane S Thornton, Kellie Wilkie, Virpi Timonen
OBJECTIVES: Low back pain (LBP) is common in rowers and leads to considerable disability and even retirement. The athlete voice can help clinicians to better understand sport-related pain disorders. We aimed to capture the lived experience of LBP in rowers. METHODS: Cross-sectional qualitative study using a grounded theory approach. Adult competitive rowers with a rowing-related LBP history were recruited in Australia and Ireland. Data were collected through interviews that explored: context around the time of onset of their LBP and their subsequent journey, experiences of management/treatment, perspectives around present beliefs, fears, barriers and expectations for the future...
March 2021: British Journal of Sports Medicine
https://read.qxmd.com/read/33028549/patient-characteristics-associated-with-a-poor-response-to-non-surgical-multidisciplinary-management-of-knee-osteoarthritis-a-multisite-prospective-longitudinal-study-in-an-advanced-practice-physiotherapist-led-tertiary-service
#5
JOURNAL ARTICLE
Shaun O'Leary, Maree Raymer, Peter Window, Patrick Swete Kelly, Bula Elwell, Ian McLoughlin, Will O'Sullivan, Ben Phillips, Anneke Wake, Andrew Ralph, Helen O'Gorman, Ellen Jang, Karen Groves, Andrew Hislop, Darryl Lee, Linda Garsden, Michael Conroy, Daniel Wickins, Bill Vicenzino, Tracy Comans, Michelle Cottrell, Asaduzzaman Khan, Steven McPhail
OBJECTIVES: To explore patient characteristics recorded at the initial consultation associated with a poor response to non-surgical multidisciplinary management of knee osteoarthritis (KOA) in tertiary care. DESIGN: Prospective multisite longitudinal study. SETTING: Advanced practice physiotherapist-led multidisciplinary orthopaedic service within eight tertiary hospitals. PARTICIPANTS: 238 patients with KOA. PRIMARY AND SECONDARY OUTCOME MEASURES: Standardised measures were recorded in all patients prior to them receiving non-surgical multidisciplinary management in a tertiary hospital service across multiple sites...
October 6, 2020: BMJ Open
https://read.qxmd.com/read/33002429/timing-of-radiotherapy-after-radical-prostatectomy-radicals-rt-a-randomised-controlled-phase-3-trial
#6
RANDOMIZED CONTROLLED TRIAL
Christopher C Parker, Noel W Clarke, Adrian D Cook, Howard G Kynaston, Peter Meidahl Petersen, Charles Catton, William Cross, John Logue, Wendy Parulekar, Heather Payne, Rajendra Persad, Holly Pickering, Fred Saad, Juliette Anderson, Amit Bahl, David Bottomley, Klaus Brasso, Rohit Chahal, Peter W Cooke, Ben Eddy, Stephanie Gibbs, Chee Goh, Sandeep Gujral, Catherine Heath, Alastair Henderson, Ramasamy Jaganathan, Henrik Jakobsen, Nicholas D James, Subramanian Kanaga Sundaram, Kathryn Lees, Jason Lester, Henriette Lindberg, Julian Money-Kyrle, Stephen Morris, Joe O'Sullivan, Peter Ostler, Lisa Owen, Prashant Patel, Alvan Pope, Richard Popert, Rakesh Raman, Martin Andreas Røder, Ian Sayers, Matthew Simms, Jim Wilson, Anjali Zarkar, Mahesh K B Parmar, Matthew R Sydes
BACKGROUND: The optimal timing of radiotherapy after radical prostatectomy for prostate cancer is uncertain. We aimed to compare the efficacy and safety of adjuvant radiotherapy versus an observation policy with salvage radiotherapy for prostate-specific antigen (PSA) biochemical progression. METHODS: We did a randomised controlled trial enrolling patients with at least one risk factor (pathological T-stage 3 or 4, Gleason score of 7-10, positive margins, or preoperative PSA ≥10 ng/mL) for biochemical progression after radical prostatectomy (RADICALS-RT)...
October 31, 2020: Lancet
https://read.qxmd.com/read/32980258/crisis-change-management-during-covid-19-in-the-elective-orthopaedic-hospital-easing-the-trauma-burden-of-acute-hospitals
#7
JOURNAL ARTICLE
John P Gibbons, Siobhan Forman, Peter Keogh, Paul Curtin, Ruth Kiely, Geraldine O'Leary, Conor Skerritt, Kathy O'Sullivan, Keith Synnott, James P Cashman, John M O'Byrne
INTRODUCTION: With the emergence of the 2019 novel coronavirus and its resulting pandemic status in March 2020 all routine elective orthopaedic surgery was cancelled in our institution. The developing picture in Italy, of acute hospitals becoming overwhelmed with treating patients suffering with severe and life-threatening symptoms from the disease, prompted the orthopaedic surgeons to formulate a plan to transfer trauma patients requiring surgery to the elective hospital to unburden the acute hospital system...
September 8, 2020: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://read.qxmd.com/read/32949123/evaluation-of-absenteeism-pain-and-disability-in-nurses-with-persistent-low-back-pain-following-cognitive-functional-therapy-a-case-series-pilot-study-with-3-year-follow-up
#8
JOURNAL ARTICLE
Wannes Van Hoof, Kieran O'Sullivan, Sabine Verschueren, Peter O'Sullivan, Wim Dankaerts
OBJECTIVE: Persistent low back pain (PLBP) is a common and costly health problem worldwide. Better strategies to manage it are required. The purpose of this study was to longitudinally evaluate absenteeism, pain, and disability in nurses with PLBP following a cognitive functional therapy (CFT) intervention. METHODS: In this case series pilot study, 33 eligible nurses with PLBP were recruited. During the baseline phase (phase A; no intervention), outcome measures were collected on 2 occasions 6 months apart (A1 and A2)...
January 4, 2021: Physical Therapy
https://read.qxmd.com/read/32935571/maximal-axial-vertebral-rotation-in-adolescent-idiopathic-scoliosis-is-the-apical-vertebra-the-most-rotated
#9
JOURNAL ARTICLE
Kristóf József, Ádám Tibor Schlégl, Máté Burkus, István Márkus, Ian O'Sullivan, Péter Than, Miklós Tunyogi Csapó
STUDY DESIGN: Retrospective cross-sectional study. OBJECTIVES: It is generally believed that the apical vertebra has the largest axial rotation in adolescent idiopathic scoliosis. We investigated the relationship between apical axial vertebral rotation (apicalAVR) and maximal axial vertebral rotation (maxAVR) in both major and minor curves using biplanar stereo-imaging. METHODS: EOS 2D/3D biplanar radiograph images were collected from 332 patients with adolescent idiopathic scoliosis (Cobb angle range 10°-122°, mean age 14...
September 16, 2020: Global Spine Journal
https://read.qxmd.com/read/32907798/there-is-more-to-pain-than-tissue-damage-eight-principles-to-guide-care-of-acute-non-traumatic-pain-in-sport
#10
EDITORIAL
J P Caneiro, Rafael Krasic Alaiti, Leandro Fukusawa, Luiz Hespanhol, Peter Brukner, Peter Pb O'Sullivan
No abstract text is available yet for this article.
January 2021: British Journal of Sports Medicine
https://read.qxmd.com/read/32900340/preventing-code-blue-false-alarms-through-a-simple-design-change-a-case-study
#11
JOURNAL ARTICLE
Zakary B Doherty, Peter A Faulkner, Jason A Fletcher, Kim L Fuzzard, Rebecca A Kippen, Belinda G O'Sullivan
No abstract text is available yet for this article.
September 2020: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://read.qxmd.com/read/32883734/readability-and-understandability-of-clinical-research-patient-information-leaflets-and-consent-forms-in-ireland-and-the-uk-a-retrospective-quantitative-analysis
#12
JOURNAL ARTICLE
Lydia O'Sullivan, Prasanth Sukumar, Rachel Crowley, Eilish McAuliffe, Peter Doran
OBJECTIVES: The first aim of this study was to quantify the difficulty level of clinical research Patient Information Leaflets/Informed Consent Forms (PILs/ICFs) using validated and widely used readability criteria which provide a broad assessment of written communication. The second aim was to compare these findings with best practice guidelines. DESIGN: Retrospective, quantitative analysis of clinical research PILs/ICFs provided by academic institutions, pharmaceutical companies and investigators...
September 3, 2020: BMJ Open
https://read.qxmd.com/read/32864676/national-osteoarthritis-strategy-brief-report-advanced-care
#13
JOURNAL ARTICLE
Xia Wang, Michelle Dowsey, Ian Harris, Peter O'Sullivan, Bill Donnelly, Thomas Buttel, Anita Wluka, Philip Clark, Raj Anand, Peter Choong, David J Hunter, Yingyu Feng, Jane M Gunn
BACKGROUND: Osteoarthritis (OA) is one of the most common chronic joint diseases and a leading cause of pain and disability in Australia. A National Osteoarthritis Strategy (the Strategy) was developed to outline a national plan to achieve optimal health outcomes for people at risk of, or with, OA. OBJECTIVE: This article focuses on the theme of advanced care of patients with OA within the Strategy. DISCUSSION: The Strategy was developed in consultation with a leadership group, thematic working groups, an implementation advisory committee, multisectoral stakeholders and the public...
September 2020: Australian Journal of General Practice
https://read.qxmd.com/read/32843463/2020-vision-a-case-of-malignant-hypertension
#14
JOURNAL ARTICLE
Richard Tanner, Bryan O'Sullivan, Liam Bourke, Peter Kelly
No abstract text is available yet for this article.
August 25, 2020: BMJ Case Reports
https://read.qxmd.com/read/32832851/protocol-for-systematic-review-of-ethical-declarations-made-in-clinical-publications-concerning-covid-19
#15
JOURNAL ARTICLE
Lydia O'Sullivan, Ronan P Killeen, Peter Doran, Rachel K Crowley
COVID-19 is a respiratory disease caused by a coronavirus, designated SARS-CoV-2, which is responsible for a global pandemic in 2020. Public interest in this disease has led to the publication of thousands of articles in the medical literature in a very short timeframe. It is imperative that medical research into COVID-19 is conducted quickly and safely, and that due reference is given to the ethical considerations enshrined in the ICH GCP guidelines, according to the Declaration of Helsinki. In order to review the reporting of ethical considerations in these papers, we hereby propose a protocol for a systematic review of COVID-19 papers up to April 14 th 2020...
2020: HRB open research
https://read.qxmd.com/read/32770086/spliceosome-mutations-are-common-in-persons-with-myeloproliferative-neoplasm-associated-myelofibrosis-with-rbc-transfusion-dependence-and-correlate-with-response-to-pomalidomide
#16
LETTER
Onima Chowdhury, Jennifer O'Sullivan, Nikolaos Barkas, Guanlin Wang, Gemma Buck, Angela Hamblin, Ayalew Tefferi, Haifa K Al-Ali, Giovanni Barosi, Timothy Devos, Heinz Gisslinger, Qian Jiang, Jean-Jacques Kiladjian, Ruben Mesa, Francesco Passamonti, Vincent Ribrag, Gary Schiller, Alessandro M Vannucchi, Daobin Zhou, Mary Frances McMullin, Jianhua Zhong, Robert Peter Gale, Adam J Mead
No abstract text is available yet for this article.
April 2021: Leukemia
https://read.qxmd.com/read/32766850/uncovering-infant-group-b-streptococcal-gbs-disease-clusters-in-the-uk-and-ireland-through-genomic-analysis-a-population-based-epidemiological-study
#17
JOURNAL ARTICLE
Simon M Collin, Natalie Groves, Catherine O'Sullivan, Elita Jauneikaite, Darshana Patel, Robert Cunney, Mary Meehan, Arlene Reynolds, Andrew Smith, Diane Lindsay, Lorraine Doherty, Eleri Davies, Victoria Chalker, Peter Lamb, Baharak Afshar, Sooria Balasegaram, Juliana Coelho, Derren Ready, Colin S Brown, Androulla Efstratiou, Kirsty Le Doare, Shiranee Sriskandan, Paul T Heath, Theresa Lamagni
BACKGROUND: The true frequency of hospital outbreaks of invasive group B streptococcal (iGBS; Streptococcus agalactiae) disease in infants is unknown. We used whole genome sequencing (WGS) of iGBS isolates collected during a period of enhanced surveillance of infant iGBS disease in the UK and Ireland to determine the number of clustered cases. METHODS: Potentially linked iGBS cases from infants with early (<7 days of life) or late-onset (7-89 days) disease were identified from WGS data (HiSeq 2500 platform, Illumina) from clinical sterile site isolates collected between 04/2014 and 04/2015...
August 7, 2020: Clinical Infectious Diseases
https://read.qxmd.com/read/32732567/what-influences-patient-satisfaction-after-tka-a-qualitative-investigation
#18
JOURNAL ARTICLE
Nardia-Rose Klem, Anne Smith, Peter O'Sullivan, Michelle M Dowsey, Robert Schütze, Peter Kent, Peter F Choong, Samantha Bunzli
BACKGROUND: Patient satisfaction is a common measure of the success of an orthopaedic intervention. However, there is poor understanding of what satisfaction means to patients or what influences it. QUESTIONS/PURPOSES: Using qualitative study methodology in patients undergoing TKA, we asked: (1) What does it mean to be satisfied after TKA? (2) What factors influence satisfaction levels after TKA? METHODS: People in a hospital registry who had completed 12-month follow-up questionnaires and were not more than 18 months post-TKA at the time of sampling were eligible (n = 121)...
August 2020: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/32694432/femoral-neck-shaft-angle-and-bone-age-in-4-to-24-year-olds-based-on-1005-eos-three-dimensional-reconstructions
#19
JOURNAL ARTICLE
Ian R O'Sullivan, Ádám T Schégl, Péter Varga, Péter Than, Csaba Vermes
The aim of the study was to assess the correlation between femoral neck-shaft angles (NSAs) and skeletal maturity in EOS reconstructions from a large population of children. Full-body three-dimensional (3D) reconstructions were generated from 1005 children and young adults (4-24 years old; 449 male, 556 female) using the EOS three-dimensional/3D scanner, with images taken during routine clinical practice. The true NSAs were measured and assessed for correlation with individuals' chronological age and bone age, based on cervical vertebral morphology...
July 17, 2020: Journal of Pediatric Orthopedics. Part B
https://read.qxmd.com/read/32659313/long-term-open-label-extension-study-of-the-efficacy-and-safety-of-epicutaneous-immunotherapy-for-peanut-allergy-in-children-people-3-year-results
#20
JOURNAL ARTICLE
David M Fleischer, Wayne G Shreffler, Dianne E Campbell, Todd D Green, Sara Anvari, Amal Assa'ad, Philippe Bégin, Kirsten Beyer, J Andrew Bird, Terri Brown-Whitehorn, Aideen Byrne, Edmond S Chan, Amarjit Cheema, Sharon Chinthrajah, Hey Jin Chong, Carla M Davis, Lara S Ford, Rémi Gagnon, Matthew Greenhawt, Jonathan O'B Hourihane, Stacie M Jones, Edwin H Kim, Lars Lange, Bruce J Lanser, Stephanie Leonard, Vera Mahler, Andreas Maronna, Anna Nowak-Wegrzyn, Roxanne C Oriel, Michael O'Sullivan, Daniel Petroni, Jacqueline A Pongracic, Susan L Prescott, Lynda C Schneider, Peter Smith, Doris Staab, Gordon Sussman, Robert Wood, William H Yang, Romain Lambert, Aurélie Peillon, Timothée Bois, Hugh A Sampson
BACKGROUND: The PEPITES (Peanut EPIT Efficacy and Safety) trial, a 12-month randomized controlled study of children with peanut allergy and 4 to 11 years old, previously reported the safety and efficacy of epicutaneous immunotherapy (EPIT) for peanut allergy (250 μg, daily epicutaneous peanut protein; DBV712 250 μg). OBJECTIVE: We sought to assess interim safety and efficacy of an additional 2 years of EPIT from the ongoing (5-year treatment) PEOPLE (PEPITES Open-Label Extension) study...
October 2020: Journal of Allergy and Clinical Immunology
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