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JOURNAL ARTICLE
Joseph Sullivan, Simon J Roberts, John Mckeown, Martin Littlewood, Christopher McLaren-Towlson, Matthew Andrew, Kevin Enright
The aim of this review was to summarise the methods used to predict and assess maturity status and timing in adolescent, male, academy soccer players. A systematic search was conducted on PubMed, Scopus, Web of Science, CINAHL, Medline and SPORTDiscus. Only experimental studies including male, academy players aged U9-U18 years registered with a professional soccer club were included. The methodological quality of the included studies was assessed using guidelines from the Framework of Potential Biases. Fifteen studies fulfilled our inclusion criteria...
2023: PloS One
#2
JOURNAL ARTICLE
Ali Al-Janabi, Amelle Ra, Zoe Littlewood, Amy C Foulkes, Hamish J A Hunter, Hector Chinoy, Christopher A Moriarty, Kimme L Hyrich, Jimmy K Limdi, Zenas Z N Yiu, Christopher E M Griffiths, Richard B Warren
BACKGROUND: Biologic and nonbiologic immunomodulators, used to treat immune-mediated inflammatory diseases (IMIDs), could impair the immune response to COVID-19 vaccines and thus vaccine effectiveness. OBJECTIVES: Our objective was to investigate the association between biologic and nonbiologic immunomodulators and seroconversion following the first and second dose of COVID-19 vaccines in patients with IMIDs. METHODS: Serum samples were collected following the first or second dose of the BNT162b2 or AZD1222 vaccines from patients receiving biologic and/or nonbiologic immunomodulators for one or more of psoriasis, psoriatic arthritis, rheumatoid arthritis, inflammatory bowel disease or systemic lupus erythematosus...
December 7, 2022: British Journal of Dermatology
#3
JOURNAL ARTICLE
Jadbinder Seehra, Andrew T DiBiase, Shruti Patel, Rachel Stephens, Simon J Littlewood, Richard J Spencer, Tom Frawley, Philip E Benson, Anthony J Ireland, Farnaz Parvizi, Nikki Atack, Giles Kidner, Gabriella Wojewodka, Christopher Ward, Spyridon N Papageorgiou, Jonathon T Newton, Martyn T Cobourne
BACKGROUND: Failure of eruption of the maxillary permanent incisor teeth usually presents in the mixed dentition between the ages of 7 and 9 years. Missing and unerupted maxillary incisors can be regarded as unattractive and have a potentially negative impact on facial and dental aesthetics. The presence of a supernumerary tooth (or odontoma) is commonly responsible for failed eruption or impaction of the permanent maxillary incisors. The primary objective of this trial is to investigate the success of eruption associated with maxillary incisor teeth that have failed to erupt because of a supernumerary tooth in the anterior maxilla...
September 16, 2022: Trials
#4
JOURNAL ARTICLE
Jonathan A Poli, Christopher Howard, Alfredo J Garcia, Don Remboski, Peter B Littlewood, John P Kress, Narayanan Kasthuri, Alia Comai, Kiran Soni, Philip Kennedy, John Ogger, Robert M DiBlasi
The COVID-19 pandemic has brought attention to the need for developing effective respiratory support that can be rapidly implemented during critical surge capacity scenarios in healthcare settings. Lung support with bubble continuous positive airway pressure (B-CPAP) is a well-established therapeutic approach for supporting neonatal patients. However, the effectiveness of B-CPAP in larger pediatric and adult patients has not been addressed. Using similar principles of B-CPAP pressure generation, application of intermittent positive pressure inflations above CPAP could support gas exchange and high work of breathing levels in larger patients experiencing more severe forms of respiratory failure...
April 2, 2022: Bioengineering
#5
JOURNAL ARTICLE
Hayley C Gorton, Lisa Riste, Donna Littlewood, Gary Pickering, Christopher J Armitage, Darren M Ashcroft
BACKGROUND: Specifically-designed community pharmacy-based services represent opportunities to support people with their mental health. As few such services exist worldwide, the Advancing Mental HeaLth Provision In PharmacY (AMPLIPHY) was designed with stakeholders. The purpose was to support people with their mental health when initiated on new prescription or change in drug, dose or quantity of antidepressant, through a series of consultations (up to 3 months). OBJECTIVE(S): The aim was to evaluate the feasibility of the AMPLIPHY service...
August 2022: Research in Social & Administrative Pharmacy: RSAP
#6
JOURNAL ARTICLE
Toshi A Furukawa, Aya Suganuma, Edoardo G Ostinelli, Gerhard Andersson, Christopher G Beevers, Jason Shumake, Thomas Berger, Florien Willemijn Boele, Claudia Buntrock, Per Carlbring, Isabella Choi, Helen Christensen, Andrew Mackinnon, Jennifer Dahne, Marcus J H Huibers, David D Ebert, Louise Farrer, Nicholas R Forand, Daniel R Strunk, Iony D Ezawa, Erik Forsell, Viktor Kaldo, Anna Geraedts, Simon Gilbody, Elizabeth Littlewood, Sally Brabyn, Heather D Hadjistavropoulos, Luke H Schneider, Robert Johansson, Robin Kenter, Marie Kivi, Cecilia Björkelund, Annet Kleiboer, Heleen Riper, Jan Philipp Klein, Johanna Schröder, Björn Meyer, Steffen Moritz, Lara Bücker, Ove Lintvedt, Peter Johansson, Johan Lundgren, Jeannette Milgrom, Alan W Gemmill, David C Mohr, Jesus Montero-Marin, Javier Garcia-Campayo, Stephanie Nobis, Anna-Carlotta Zarski, Kathleen O'Moore, Alishia D Williams, Jill M Newby, Sarah Perini, Rachel Phillips, Justine Schneider, Wendy Pots, Nicole E Pugh, Derek Richards, Isabelle M Rosso, Scott L Rauch, Lisa B Sheeber, Jessica Smith, Viola Spek, Victor J Pop, Burçin Ünlü, Kim M P van Bastelaar, Sanne van Luenen, Nadia Garnefski, Vivian Kraaij, Kristofer Vernmark, Lisanne Warmerdam, Annemieke van Straten, Pavle Zagorscak, Christine Knaevelsrud, Manuel Heinrich, Clara Miguel, Andrea Cipriani, Orestis Efthimiou, Eirini Karyotaki, Pim Cuijpers
BACKGROUND: Internet cognitive behavioural therapy (iCBT) is a viable delivery format of CBT for depression. However, iCBT programmes include training in a wide array of cognitive and behavioural skills via different delivery methods, and it remains unclear which of these components are more efficacious and for whom. METHODS: We did a systematic review and individual participant data component network meta-analysis (cNMA) of iCBT trials for depression. We searched PubMed, PsycINFO, Embase, and the Cochrane Library for randomised controlled trials (RCTs) published from database inception to Jan 1, 2019, that compared any form of iCBT against another or a control condition in the acute treatment of adults (aged ≥18 years) with depression...
June 2021: Lancet Psychiatry
#7
JOURNAL ARTICLE
Eirini Karyotaki, Orestis Efthimiou, Clara Miguel, Frederic Maas Genannt Bermpohl, Toshi A Furukawa, Pim Cuijpers, Heleen Riper, Vikram Patel, Adriana Mira, Alan W Gemmil, Albert S Yeung, Alfred Lange, Alishia D Williams, Andrew Mackinnon, Anna Geraedts, Annemieke van Straten, Björn Meyer, Cecilia Björkelund, Christine Knaevelsrud, Christopher G Beevers, Cristina Botella, Daniel R Strunk, David C Mohr, David D Ebert, David Kessler, Derek Richards, Elizabeth Littlewood, Erik Forsell, Fan Feng, Fang Wang, Gerhard Andersson, Heather Hadjistavropoulos, Heleen Christensen, Iony D Ezawa, Isabella Choi, Isabelle M Rosso, Jan Philipp Klein, Jason Shumake, Javier Garcia-Campayo, Jeannette Milgrom, Jessica Smith, Jesus Montero-Marin, Jill M Newby, Juana Bretón-López, Justine Schneider, Kristofer Vernmark, Lara Bücker, Lisa B Sheeber, Lisanne Warmerdam, Louise Farrer, Manuel Heinrich, Marcus J H Huibers, Marie Kivi, Martin Kraepelien, Nicholas R Forand, Nicky Pugh, Nils Lindefors, Ove Lintvedt, Pavle Zagorscak, Per Carlbring, Rachel Phillips, Robert Johansson, Ronald C Kessler, Sally Brabyn, Sarah Perini, Scott L Rauch, Simon Gilbody, Steffen Moritz, Thomas Berger, Victor Pop, Viktor Kaldo, Viola Spek, Yvonne Forsell
IMPORTANCE: Personalized treatment choices would increase the effectiveness of internet-based cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in interventions that better suit them. OBJECTIVE: To provide personalized estimates of short-term and long-term relative efficacy of guided and unguided iCBT for depression using patient-level information. DATA SOURCES: We searched PubMed, Embase, PsycInfo, and Cochrane Library to identify randomized clinical trials (RCTs) published up to January 1, 2019...
April 1, 2021: JAMA Psychiatry
#8
JOURNAL ARTICLE
Alasdair L Henry, Christopher B Miller, Richard Emsley, Bryony Sheaves, Daniel Freeman, Annemarie I Luik, Donna L Littlewood, Kate E A Saunders, Jennifer C Kanady, Jenna R Carl, Michelle L Davis, Simon D Kyle, Colin A Espie
Insomnia predicts the onset of depression, commonly co-presents with depression and often persists following depression remission. However, these conditions can be challenging to treat concurrently using depression-specific therapies. Cognitive behavioural therapy for insomnia may be an appropriate treatment to improve both insomnia and depressive symptoms. We examined the effects of a fully-automated digital cognitive behavioural therapy intervention for insomnia (Sleepio) on insomnia and depressive symptoms, and the mediating role of sleep improvement on depressive symptoms in participants from two randomized controlled trials of digital cognitive behavioural therapy for insomnia...
February 2021: Journal of Sleep Research
#9
JOURNAL ARTICLE
Anna Schubart, Karen Anderson, Nello Mainolfi, Holger Sellner, Takeru Ehara, Christopher M Adams, Aengus Mac Sweeney, Sha-Mei Liao, Maura Crowley, Amanda Littlewood-Evans, Sophie Sarret, Grazyna Wieczorek, Ludovic Perrot, Valérie Dubost, Thierry Flandre, Yuzhou Zhang, Richard J H Smith, Antonio M Risitano, Rajeshri G Karki, Chun Zhang, Eric Valeur, Finton Sirockin, Bernd Gerhartz, Paulus Erbel, Nicola Hughes, Thomas M Smith, Frederic Cumin, Upendra A Argikar, Börje Haraldsson, Muneto Mogi, Richard Sedrani, Christian Wiesmann, Bruce Jaffee, Jürgen Maibaum, Stefanie Flohr, Richard Harrison, Jörg Eder
Dysregulation of the alternative complement pathway (AP) predisposes individuals to a number of diseases including paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and C3 glomerulopathy. Moreover, glomerular Ig deposits can lead to complement-driven nephropathies. Here we describe the discovery of a highly potent, reversible, and selective small-molecule inhibitor of factor B, a serine protease that drives the central amplification loop of the AP. Oral administration of the inhibitor prevents KRN-induced arthritis in mice and is effective upon prophylactic and therapeutic dosing in an experimental model of membranous nephropathy in rats...
April 16, 2019: Proceedings of the National Academy of Sciences of the United States of America
#10
JOURNAL ARTICLE
Sean A Locke, Alex Van Dam, Monica Caffara, Hudson Alves Pinto, Danimar López-Hernández, Christopher A Blanar
Higher systematics within the Digenea, Carus 1863 have been relatively stable since a phylogenetic analysis of partial nuclear ribosomal markers (rDNA) led to the erection of the Diplostomida Olson, Cribb, Tkach, Bray, and Littlewood, 2003. However, recent mitochondrial (mt) genome phylogenies suggest this order might be paraphyletic. These analyses show members of two diplostomidan superfamilies are more closely related to the Plagiorchiida La Rue, 1957 than to other members of the Diplostomida. A recent phylogeny based on partial cytochrome c oxidase I also indicates one of the groups implicated, the Diplostomoidea Poirier, 1886, is non-monophyletic...
November 2018: International Journal for Parasitology
#11
JOURNAL ARTICLE
Klemens Hoegenauer, Nicolas Soldermann, Frédéric Zécri, Ross S Strang, Nadege Graveleau, Romain M Wolf, Nigel G Cooke, Alexander B Smith, Gregory J Hollingworth, Joachim Blanz, Sascha Gutmann, Gabriele Rummel, Amanda Littlewood-Evans, Christoph Burkhart
The predominant expression of phosphoinositide 3-kinase δ (PI3Kδ) in leukocytes and its critical role in B and T cell functions led to the hypothesis that selective inhibitors of this isoform would have potential as therapeutics for the treatment of allergic and inflammatory disease. Targeting specifically PI3Kδ should avoid potential side effects associated with the ubiquitously expressed PI3Kα and β isoforms. We disclose how morphing the heterocyclic core of previously discovered 4,6-diaryl quinazolines to a significantly less lipophilic 5,6,7,8-tetrahydropyrido[4,3- d ]pyrimidine, followed by replacement of one of the phenyl groups with a pyrrolidine-3-amine, led to a compound series with an optimal on-target profile and good ADME properties...
September 14, 2017: ACS Medicinal Chemistry Letters
#12
MULTICENTER STUDY
Toby A Eyre, Ruth Clifford, Adrian Bloor, Lucy Boyle, Corran Roberts, Maite Cabes, Graham P Collins, Stephen Devereux, George Follows, Christopher P Fox, John Gribben, Peter Hillmen, Chris S Hatton, Tim J Littlewood, Helen McCarthy, Jim Murray, Andrew R Pettitt, Elizabeth Soilleux, Basile Stamatopoulos, Sharon B Love, Andrew Wotherspoon, Anna Schuh
Richter syndrome (RS) is associated with chemotherapy resistance and a poor historical median overall survival (OS) of 8-10 months. We conducted a phase II trial of standard CHOP-21 (cyclophosphamide, doxorubicin, vincristine, prednisolone every 21 d) with ofatumumab induction (Cycle 1: 300 mg day 1, 1000 mg day 8, 1000 mg day 15; Cycles 2-6: 1000 mg day 1) (CHOP-O) followed by 12 months ofatumumab maintenance (1000 mg given 8-weekly for up to six cycles). Forty-three patients were recruited of whom 37 were evaluable...
October 2016: British Journal of Haematology
#13
JOURNAL ARTICLE
S Dein, S Dein, R Littlewood, Y Oloyede, I B Krause, N Argenti
Millennialism and violence Michael Barkun (Ed.) London, Frank Cass, 1996, 177 pp. Evil and suffering in Jewish philosophy Oliver Leaman Cambridge, Cambridge University Press, 1995, 157 pp. Religion and the clinical practice of psychology Edward P. Shafranski (ed.) Washington DC, American Psychological Association, 1996, 619 pp., index, bibliographies, figures. Beyond reason: art and psychosis: works from the Prinzhorn Collection London, Hayward Gallery, 1997, £12.95, 195 pp., index, bibliography Madness and art: the life and works of Adolf Wölfli Walter Morgenthaler Lincoln, University of Nebraska Press, 1992, $35...
April 1998: Anthropology & Medicine
#14
RANDOMIZED CONTROLLED TRIAL
Christopher J Hawkey, Matthieu Allez, Miranda M Clark, Myriam Labopin, James O Lindsay, Elena Ricart, Gerhard Rogler, Montserrat Rovira, Jack Satsangi, Silvio Danese, Nigel Russell, John Gribben, Peter Johnson, Jerome Larghero, Catherine Thieblemont, Sandro Ardizzone, Daan Dierickx, Adalberto Ibatici, Timothy Littlewood, Francesco Onida, Urs Schanz, Severine Vermeire, Jean-Frederic Colombel, Jean-Paul Jouet, Elizabeth Clark, Riccardo Saccardi, Alan Tyndall, Simon Travis, Dominique Farge
IMPORTANCE: Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease. OBJECTIVE: To evaluate the effect of autologous HSCT on refractory Crohn disease. DESIGN, SETTING, AND PARTICIPANTS: Parallel-group randomized clinical trial conducted in 11 European transplant units from July 2007 to September 2011, with follow-up through March 2013. Patients were aged 18 to 50 years with impaired quality of life from refractory Crohn disease not amenable to surgery despite treatment with 3 or more immunosuppressive or biologic agents and corticosteroids...
December 15, 2015: JAMA
#15
JOURNAL ARTICLE
Mario J N M Ouwens, Kavi J Littlewood, Christophe Sauboin, Bertrand Téhard, François Denis, Pierre-Yves Boëlle, Sophie Alain
PURPOSE: Varicella has a high incidence affecting the vast majority of the population in France and can lead to severe complications. Almost every individual infected by varicella becomes susceptible to herpes zoster later in life due to reactivation of the latent virus. Zoster is characterized by pain that can be long-lasting in some cases and has no satisfactory treatment. Routine varicella vaccination can prevent varicella. The vaccination strategy of replacing both doses of measles, mumps, and rubella (MMR) with a combined MMR and varicella (MMRV) vaccine is a means of reaching high vaccination coverage for varicella immunization...
April 1, 2015: Clinical Therapeutics
#16
JOURNAL ARTICLE
Kavi J Littlewood, Mario J N M Ouwens, Christophe Sauboin, Bertrand Tehard, Sophie Alain, François Denis
PURPOSE: Each year in France, varicella and zoster affect large numbers of children and adults, resulting in medical visits, hospitalizations for varicella- and zoster-related complications, and societal costs. Disease prevention by varicella vaccination is feasible, wherein a plausible option involves replacing the combined measles, mumps, and rubella (MMR) vaccine with the combined MMR and varicella (MMRV) vaccine. This study aimed to: (1) assess the cost-effectiveness of adding routine varicella vaccination through MMRV, using different vaccination strategies in France; and (2) address key uncertainties, such as the economic consequences of breakthrough varicella cases, the waning of vaccine-conferred protection, vaccination coverage, and indirect costs...
April 1, 2015: Clinical Therapeutics
#17
JOURNAL ARTICLE
Lawrence N Hudson, Tim Newbold, Sara Contu, Samantha L L Hill, Igor Lysenko, Adriana De Palma, Helen R P Phillips, Rebecca A Senior, Dominic J Bennett, Hollie Booth, Argyrios Choimes, David L P Correia, Julie Day, Susy Echeverría-Londoño, Morgan Garon, Michelle L K Harrison, Daniel J Ingram, Martin Jung, Victoria Kemp, Lucinda Kirkpatrick, Callum D Martin, Yuan Pan, Hannah J White, Job Aben, Stefan Abrahamczyk, Gilbert B Adum, Virginia Aguilar-Barquero, Marcelo A Aizen, Marc Ancrenaz, Enrique Arbeláez-Cortés, Inge Armbrecht, Badrul Azhar, Adrián B Azpiroz, Lander Baeten, András Báldi, John E Banks, Jos Barlow, Péter Batáry, Adam J Bates, Erin M Bayne, Pedro Beja, Åke Berg, Nicholas J Berry, Jake E Bicknell, Jochen H Bihn, Katrin Böhning-Gaese, Teun Boekhout, Céline Boutin, Jérémy Bouyer, Francis Q Brearley, Isabel Brito, Jörg Brunet, Grzegorz Buczkowski, Erika Buscardo, Jimmy Cabra-García, María Calviño-Cancela, Sydney A Cameron, Eliana M Cancello, Tiago F Carrijo, Anelena L Carvalho, Helena Castro, Alejandro A Castro-Luna, Rolando Cerda, Alexis Cerezo, Matthieu Chauvat, Frank M Clarke, Daniel F R Cleary, Stuart P Connop, Biagio D'Aniello, Pedro Giovâni da Silva, Ben Darvill, Jens Dauber, Alain Dejean, Tim Diekötter, Yamileth Dominguez-Haydar, Carsten F Dormann, Bertrand Dumont, Simon G Dures, Mats Dynesius, Lars Edenius, Zoltán Elek, Martin H Entling, Nina Farwig, Tom M Fayle, Antonio Felicioli, Annika M Felton, Gentile F Ficetola, Bruno K C Filgueiras, Steven J Fonte, Lauchlan H Fraser, Daisuke Fukuda, Dario Furlani, Jörg U Ganzhorn, Jenni G Garden, Carla Gheler-Costa, Paolo Giordani, Simonetta Giordano, Marco S Gottschalk, Dave Goulson, Aaron D Gove, James Grogan, Mick E Hanley, Thor Hanson, Nor R Hashim, Joseph E Hawes, Christian Hébert, Alvin J Helden, John-André Henden, Lionel Hernández, Felix Herzog, Diego Higuera-Diaz, Branko Hilje, Finbarr G Horgan, Roland Horváth, Kristoffer Hylander, Paola Isaacs-Cubides, Masahiro Ishitani, Carmen T Jacobs, Víctor J Jaramillo, Birgit Jauker, Mats Jonsell, Thomas S Jung, Vena Kapoor, Vassiliki Kati, Eric Katovai, Michael Kessler, Eva Knop, Annette Kolb, Ádám Kőrösi, Thibault Lachat, Victoria Lantschner, Violette Le Féon, Gretchen LeBuhn, Jean-Philippe Légaré, Susan G Letcher, Nick A Littlewood, Carlos A López-Quintero, Mounir Louhaichi, Gabor L Lövei, Manuel Esteban Lucas-Borja, Victor H Luja, Kaoru Maeto, Tibor Magura, Neil Aldrin Mallari, Erika Marin-Spiotta, E J P Marshall, Eliana Martínez, Margaret M Mayfield, Grzegorz Mikusinski, Jeffrey C Milder, James R Miller, Carolina L Morales, Mary N Muchane, Muchai Muchane, Robin Naidoo, Akihiro Nakamura, Shoji Naoe, Guiomar Nates-Parra, Dario A Navarrete Gutierrez, Eike L Neuschulz, Norbertas Noreika, Olivia Norfolk, Jorge Ari Noriega, Nicole M Nöske, Niall O'Dea, William Oduro, Caleb Ofori-Boateng, Chris O Oke, Lynne M Osgathorpe, Juan Paritsis, Alejandro Parra-H, Nicolás Pelegrin, Carlos A Peres, Anna S Persson, Theodora Petanidou, Ben Phalan, T Keith Philips, Katja Poveda, Eileen F Power, Steven J Presley, Vânia Proença, Marino Quaranta, Carolina Quintero, Nicola A Redpath-Downing, J Leighton Reid, Yana T Reis, Danilo B Ribeiro, Barbara A Richardson, Michael J Richardson, Carolina A Robles, Jörg Römbke, Luz Piedad Romero-Duque, Loreta Rosselli, Stephen J Rossiter, T'ai H Roulston, Laurent Rousseau, Jonathan P Sadler, Szabolcs Sáfián, Romeo A Saldaña-Vázquez, Ulrika Samnegård, Christof Schüepp, Oliver Schweiger, Jodi L Sedlock, Ghazala Shahabuddin, Douglas Sheil, Fernando A B Silva, Eleanor M Slade, Allan H Smith-Pardo, Navjot S Sodhi, Eduardo J Somarriba, Ramón A Sosa, Jane C Stout, Matthew J Struebig, Yik-Hei Sung, Caragh G Threlfall, Rebecca Tonietto, Béla Tóthmérész, Teja Tscharntke, Edgar C Turner, Jason M Tylianakis, Adam J Vanbergen, Kiril Vassilev, Hans A F Verboven, Carlos H Vergara, Pablo M Vergara, Jort Verhulst, Tony R Walker, Yanping Wang, James I Watling, Konstans Wells, Christopher D Williams, Michael R Willig, John C Z Woinarski, Jan H D Wolf, Ben A Woodcock, Douglas W Yu, Andrey S Zaitsev, Ben Collen, Rob M Ewers, Georgina M Mace, Drew W Purves, Jörn P W Scharlemann, Andy Purvis
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project - and avert - future declines...
December 2014: Ecology and Evolution
#18
COMPARATIVE STUDY
Keith E Littlewood, Ashley M Shilling, Christopher J Stemland, Elisabeth B Wright, Mark A Kirk
BACKGROUND: Case-based discussion (CBD) is an established method for active learning in medical education. High-fidelity simulation has emerged as an important new educational technology. There is limited data from direct comparisons of these modalities. AIMS: The primary purpose of this study was to compare the effectiveness of high-fidelity medical simulation with CBD in an undergraduate medical curriculum for shock. METHODS: The subjects were 85 third-year medical students in their required surgery rotation...
2013: Medical Teacher
#19
JOURNAL ARTICLE
Ruth E Curran, Christopher R J Claxton, Laura Hutchison, Paul J Harradine, Iain J Martin, Peter Littlewood
Past publications have highlighted the influence of postdialysis plasma pH on the measured fraction unbound in plasma (fup). There is disparity in the industry as to which of two main methods is more suitable for controlling postdialysis plasma pH: the use of either a stronger buffer or a CO(2) atmosphere for the incubation. In the current study, it has been found that 10% CO(2) could be too high for the buffering capacities of both 100 mM sodium phosphate (pH 7.40 decreased to pH 6.90 after a 6-h incubation) and plasma (decreased below pH 7...
March 2011: Drug Metabolism and Disposition: the Biological Fate of Chemicals
#20
JOURNAL ARTICLE
Magdalena Koziczak-Holbro, Amanda Littlewood-Evans, Bernadette Pöllinger, Jiri Kovarik, Janet Dawson, Gerhard Zenke, Christoph Burkhart, Matthias Müller, Hermann Gram
OBJECTIVE: We have previously reported that the kinase activity of interleukin-1 receptor-associated kinase 4 (IRAK-4) is important for Toll-like receptor and interleukin-1 receptor signaling in vitro. Using mice devoid of IRAK-4 kinase activity (IRAK-4 KD mice), we undertook this study to determine the importance of IRAK-4 kinase function in complex disease models of joint inflammation. METHODS: IRAK-4 KD mice were subjected to serum transfer-induced (K/BxN) arthritis, and migration of transferred spleen lymphocytes into joints and cartilage and bone degradation were assessed...
June 2009: Arthritis and Rheumatism
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