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Daniel C Sukato, Daniel P Ballard, Jason M Abramowitz, Richard M Rosenfeld, Stefan Mlot
OBJECTIVE: The aim of this systematic review is to compare the perioperative outcomes of robotic versus conventional neck dissection in patients with head and neck malignancy. METHODS: An electronic search of PubMed, Web of Science, and EMBASE databases was conducted. We included studies with direct comparisons of robotic and open neck dissections and performed dual, independent data extraction for primary outcomes of nodal yield, recurrence rate, subjective cosmetic assessment, operative time, length of stay, and rates of perioperative complications...
October 16, 2018: Laryngoscope
Mehdi Koushki, Nasrin Amiri Dash Atan, Hossein Omidi-Ardali, Mostafa Rezaei Tavirani
Background: Pre-eclampsia (PE) is a pregnancy disorder characterized by hypertension and proteinuria. The evidence has suggested that microRNAs (miRs) are associated with pre-eclampsia pathogenesis; however, these results are inconsistent. The aim of this study was to assess the association between miR-210 expression and PE risk. Methods: Previous studies were selected using PubMed, Scopus, MEDLINE, EMBASE, Science Direct, Google Scholar, Directory of Open Access Journals (DOAJ), and Scientific Information Database (SID)...
October 2018: Reports of Biochemistry & Molecular Biology
Sarah Barber, Graham Thornicroft
This mini-review considers the mortality gap in persons with severe mental disorder (SMD) globally. Current estimates of 10-20 years of potential life lost may be too conservative, both in high (HIC) and low and middle-income countries (LMICs). There is an emerging consensus that natural causes account for the majority of deaths in persons with SMD in both resource settings. In HICs, cardiovascular causes predominate, and can be attributed to individual, health-system and societal level risk factors. Psychosocial lifestyle interventions target behavior specific risk factors for physical ill-health...
2018: Frontiers in Psychiatry
Peter Larsen, Michael S Rathleff, Rasmus Elsoe
INTRODUCTION: Despite fractures of the ankle being very common, there is a lack of clarity regarding the relative effectiveness of conservative versus surgical treatment. The purpose of this systematic review and meta-analysis was to investigate the clinical effects, benefits, and harms of surgical versus conservative treatment of ankle fractures in adults. METHODS: A systematic search strategy was conducted in the databases: Pubmed, Embase, Web of Science, and Cochrane up until the 16th of August 2017...
March 1, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Theo Jaspers, Jan Taeymans, Anja Hirschmüller, Heiner Baur, Roger Hilfiker, Slavko Rogan
BACKGROUND: This systematic review and meta-analysis evaluates the results of empirical studies on the effects of CPM on rehabilitation after ACL reconstruction. The research question was: what are the effects of CPM on ROM, swelling and pain after ACL reconstruction? PATIENTS/MATERIAL AND METHODS: We searched in MEDLINE, Embase, CINAHL, Cochrane and PEDro up to January 2018. Standardized mean differences (SMD) were expressed as Hedges' g, in order to correct for overestimation of the true effect in small study samples...
October 15, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
Niranjan J Sathianathen, Arveen Kalapara, Mark Frydenberg, Nathan Lawrentschuk, Christopher J Weight, Dipen Parekh, Badrinath R Konety
PURPOSE: To perform an updated systematic review and meta-analysis evaluating patient important outcomes for patients undergoing robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC). MATERIALS AND METHODS: Multiple scientific databases were searched up to July 2018 for randomized controlled trials that compared RARC and ORC. The primary outcomes of interest were: disease progression, major (Clavien III-V) complications and 90-day quality of life...
October 12, 2018: Journal of Urology
Ya-Nan Song, Ping Wang, Wei Xu, Jie-Qiong Li, Xi-Peng Cao, Jin-Tai Yu, Lan Tan
BACKGROUND: The conclusions about risk factors for rapid cognitive decline (RCD) in Alzheimer's disease (AD) and mild cognitive impairment (MCI) remain contradictory. OBJECTIVE: To explore the factors predicting RCD in AD and MCI. METHODS: We searched the PubMed, EMBASE, and the Cochrane Library from inception to May 27, 2017 for studies investigating factors associated with faster cognitive progression in AD and MCI. Effect sizes were meta-analyzed using fixed-effects and random-effects models...
September 29, 2018: Journal of Alzheimer's Disease: JAD
Caroline A Fisher, Sonja Skocic, Kathleen A Rutherford, Sarah E Hetrick
BACKGROUND: Anorexia nervosa (AN) is characterised by a failure to maintain a normal body weight due to a paucity of nutrition, an intense fear of gaining weight or behaviour that prevents the individual from gaining weight, or both. The long-term prognosis is often poor, with severe developmental, medical and psychosocial complications, high rates of relapse and mortality. 'Family therapy approaches' indicate a range of approaches, derived from different theories, that involve the family in treatment...
October 15, 2018: Cochrane Database of Systematic Reviews
Andrew D Williams, Marie-Louise Bird, Sibella Gk Hardcastle, Mark Kirschbaum, Kathryn J Ogden, Julia Ae Walters
BACKGROUND: Current treatment modalities for cancer have been successful in achieving improved survivorship; however, they come with a number of long-term adverse effects. Accidental falls are a common and clinically significant adverse event in people living with and beyond cancer and rates are higher than in the rest of the population. OBJECTIVES: To assess the effects of prescribed or provided exercise for reducing accidental falls, and falls risk factors of strength, flexibility and balance, in people living with and beyond cancer...
October 15, 2018: Cochrane Database of Systematic Reviews
Andrea Iannone, Marinella Ruospo, Germaine Wong, Michele Barone, Mariabeatrice Principi, Alfredo Di Leo, Giovanni F M Strippoli
Background: Diverticular disease treatment is limited to fibres, antibiotics, and surgery. There is conflicting evidence on mesalazine benefits and harms. Aim: We systematically reviewed current evidence on benefits and harms of mesalazine versus all other treatments in people with diverticular disease. Methods: We searched MEDLINE, EMBASE, CENTRAL, for studies published to July 2018. We estimated risk ratios (RR) for dichotomous outcomes (disease remission/recurrence, acute diverticulitis in symptomatic uncomplicated diverticular disease, need for surgery/hospitalization, all-cause/disease-related mortality, adverse events), mean differences (MD) or standardized MD (SMD) for continuous outcomes (quality of life, symptoms score, time to recurrence/remission), and their 95% confidence intervals (CI) using random-effects models...
2018: Canadian Journal of Gastroenterology & Hepatology
Taro Kishi, Kazuto Oya, Yuki Matsui, Ikuo Nomura, Kenji Sakuma, Makoto Okuya, Yuki Matsuda, Kiyoshi Fujita, Toshihiko Funahashi, Reiji Yoshimura, Nakao Iwata
Purpose: The purpose of this study was to compare the efficacy and safety of brexpiprazole 4 mg/day (B4) and 2 mg/day (B2) for treating acute schizophrenia. Patients and methods: We performed three categorical meta-analyses (B4 vs placebo, B2 vs placebo, and B4 vs B2) of double-blind, randomized placebo-controlled trials (DBRCTs) that reported improvements in the Positive and Negative Syndrome Scale (PANSS) scores, response rate, Clinical Global Impression-Improvement and Severity (CGI-I and CGI-S) scores, discontinuation rate, and incidence of individual adverse events...
2018: Neuropsychiatric Disease and Treatment
João Paulo Lopes-Silva, Reid Reale, Emerson Franchini
The aim of this study was to perform a systematic review and meta-analysis on the acute and chronic effects of sodium bicarbonate (NaHCO3 ) ingestion on Wingate performance. Following a search through PubMed, Scopus and Web of Science, 9 studies were found meeting inclusion criteria (6 acute and 3 chronic). Random-effects meta-analysis of standardized mean difference (SMD) for peak and mean power was performed. Study quality was assessed using the QualSyst. Results of the meta-analysis showed that acute ingestion of NaHCO3 did not improve Wingate test peak (weighted average effect size Hedges's g = 0...
October 13, 2018: Journal of Sports Sciences
Akira Kuriyama, Hirokazu Maeda, Rao Sun
BACKGROUND: Postoperative sore throat negatively affects patient recovery and satisfaction levels. We conducted a systematic review and meta-analysis to assess the efficacy and safety of aerosolized corticosteroids in the prevention of postoperative sore throat in adults undergoing tracheal intubation for surgery. METHODS: We searched Medline, EMBASE, China National Knowledge Infrastructure, and the Cochrane Central Register of Controlled Trials for eligible studies from inception to 13 May 2018...
October 14, 2018: Acta Anaesthesiologica Scandinavica
C Deckers, P Stephan, K E Wever, C R Hooijmans, G Hannink
OBJECTIVE: It is unclear if anterior cruciate ligament (ACL) reconstruction can prevent the onset of degenerative changes in the knee. Previous studies were inconclusive on this subject. The aim of this study was to systematically review all studies on the effect of ACL reconstruction on articular cartilage in animals. DESIGN: Pubmed and Embase were searched to identify all original articles concerning the effect of ACL reconstruction on articular cartilage compared with both its positive (ACL transection) and negative (sham and/or non-operated) control in animals...
October 11, 2018: Osteoarthritis and Cartilage
Miranda Buhler, Cathy M Chapple, Simon Stebbings, Bahram Sangelaji, G David Baxter
OBJECTIVE: To examine the effectiveness of splinting for reducing pain and improving function and health-related quality of life (HR-QoL) in people with thumb carpometacarpal osteoarthritis (CMC OA). DESIGN: The Cochrane Library, MEDLINE, Embase, CINAHL, ISI Web of Science, Scopus and Google Scholar, 3 trial registries and 4 conference proceedings were systematically searched for randomised and non-randomised controlled trials up to March 17th , 2018. Two reviewers independently applied the inclusion criteria to select potential studies and assess risk of methodologic bias using the Cochrane Collaboration's Risk of Bias Tool...
October 11, 2018: Osteoarthritis and Cartilage
Gian Luca Erre, Panagiotis Paliogiannis, Floriana Castagna, Arduino Aleksander Mangoni, Ciriaco Carru, Giuseppe Passiu, Angelo Zinellu
BACKGROUND: We conducted a meta-analysis to review the available evidence regarding the associations between peripheral blood neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and the presence of rheumatoid arthritis (RA). METHODS: PubMed, Web of Science, and Scopus, from inception to January 2018, were searched for studies reporting on NLR and PLR in RA in comparison to healthy subjects. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%...
October 13, 2018: European Journal of Clinical Investigation
Sho Moriguchi, Akihiro Takamiya, Yoshihiro Noda, Nobuyuki Horita, Masataka Wada, Sakiko Tsugawa, Eric Plitman, Yasunori Sano, Ryosuke Tarumi, Muhammad ElSalhy, Nariko Katayama, Kamiyu Ogyu, Takahiro Miyazaki, Taishiro Kishimoto, Ariel Graff-Guerrero, Jeffrey H Meyer, Daniel M Blumberger, Zafiris J Daskalakis, Masaru Mimura, Shinichiro Nakajima
Alterations in glutamatergic neurotransmission are implicated in the pathophysiology of depression, and the glutamatergic system represents a treatment target for depression. To summarize the nature of glutamatergic alterations in patients with depression, we conducted a meta-analysis of proton magnetic resonance (1 H-MRS) spectroscopy studies examining levels of glutamate. We used the search terms: depress* AND (MRS OR "magnetic resonance spectroscopy"). The search was performed with MEDLINE, Embase, and PsycINFO...
October 12, 2018: Molecular Psychiatry
Dennis R Louie, Shannon B Lim, Janice J Eng
BACKGROUND: Mirror therapy is less commonly used to target the lower extremity after stroke to improve outcomes but is simple to perform. This review and meta-analysis aimed to evaluate the efficacy of lower extremity mirror therapy in improving balance, gait, and motor function for individuals with stroke. METHODS: PubMed, Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, Physiotherapy Evidence Database, and PsychINFO were searched from inception to May 2018 for randomized controlled trials (RCTs) comparing lower extremity mirror therapy to a control intervention for people with stroke...
October 9, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Yong Zhang, Tean Ma, Pan Zhang
BACKGROUND: Recent evidence has shown that nicotinamide treatment may have an impact on phosphorus metabolism in hemodialysis patients. Nevertheless, the treatment remains controversial. This study aimed to precisely estimate the efficacy and safety of nicotinamide on phosphorus, calcium and iPTH in hemodialysis patients. METHODS: We searched numerous information sources regarding randomized controlled trials (RCTs) of nicotinamide treatment in hemodialysis patients, including PubMed, EMBASE, and the Cochrane Library...
October 2018: Medicine (Baltimore)
Motahareh Hasani, Shirin Djalalinia, Farshad Sharifi, Mehdi Varmaghani, Maryam Zarei, Mohammad Esmaeili Abdar, Hamid Asayesh, Mehdi Noroozi, Amir Kasaeian, Armita Mahdavi Gorabi, Mostafa Qorbani
Selenium is an essential mineral that plays a key role in plenty of major metabolic processes. A growing body of literature has shown that selenium deficiency leads to an increase in plasma TC and TG levels. This study explores the effect of selenium supplementation on serum level of lipid profile [total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low density lipoprotein (VLDL)]. We systematically searched PubMed/MEDLINE, ISI/WOS, and Scopus (from their commencements to Jan 2016) to identify the papers investigating the association between the intake of selenium and lipid profile...
October 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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