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Robert T Mathie, Susanne Ulbrich-Zürni, Petter Viksveen, E Rachel Roberts, Elizabeth S Baitson, Lynn A Legg, Jonathan R T Davidson
BACKGROUND:  This study focuses on randomised controlled trials (RCTs) of individualised homeopathic treatment (IHT) in which the control (comparator) group was other than placebo (OTP). AIMS:  To determine the comparative effectiveness of IHT on health-related outcomes in adults and children for any clinical condition that has been the subject of at least one OTP-controlled trial. For each study, to assess the risk of bias and to determine whether its study attitude was predominantly 'pragmatic' or 'explanatory'...
August 18, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
Leizhen Duan, Zonggui Xue, Huanwen Ji, Dongdong Zhang, Yan Wang
BACKGROUND AND OBJECTIVE: CYP2R1 is a key gene in the vitamin D metabolic pathway. It has been suggested that CYP2R1 gene variants in European populations are associated with concentrations of 25(OH)D, a biomarker of vitamin D levels and status in peripheral blood. However, a comprehensive meta-analysis of this effect including different ethnicities has never been conducted. The objective of this meta-analysis was to evaluate the association between CYP2R1 gene variants and 25(OH)D levels and vitamin D status...
August 15, 2018: Gene
Yiyang Gao, Hengrui Liang, Luhao Liu, Alberto Gurioli, Wenqi Wu
OBJECTIVE: A meta-analysiswas conducted to compare alpha-blocker and antimuscarinic monotherapies in releasing US-related symptoms. METHOD: A comprehensive literature search was performed on online databases PubMed, Web of Science, Medline, and Cochrane library. Ureteric Symptom Score Questionnaire (USSQ), International Prostate Symptom Score (IPSS), quality of life (QoL) and visual analogue pain scale (VAPS) were pooled and compared. Statistical significance was taken as two-sided p<0...
August 18, 2018: Urology Journal
Matej Stuhec, Petar Lukić, Igor Locatelli
OBJECTIVE: Psychostimulants are the first-line treatment in adults with attention-deficit hyperactivity disorder (ADHD). This meta-analysis aimed to evaluate the efficacy, acceptability, and tolerability of lisdexamfetamine (LDX), mixed amphetamine salts (MASs), modafinil (MDF), and methylphenidate (MPH) in comparison with placebo. DATA SOURCES: We systematically searched PubMed/MEDLINE and in May 2016, along with CENTRAL and EU Clinical Trials Register in February 2016, for the randomized, double-blind, placebo-controlled, parallel-group clinical trials conducted on adults diagnosed with ADHD...
August 17, 2018: Annals of Pharmacotherapy
Rishad Khan, Joanne Plahouras, Bradley C Johnston, Michael A Scaffidi, Samir C Grover, Catharine M Walsh
BACKGROUND: Endoscopy has traditionally been taught with novices practicing on real patients under the supervision of experienced endoscopists. Recently, the growing awareness of the need for patient safety has brought simulation training to the forefront. Simulation training can provide trainees with the chance to practice their skills in a learner-centred, risk-free environment. It is important to ensure that skills gained through simulation positively transfer to the clinical environment...
August 17, 2018: Cochrane Database of Systematic Reviews
Kenji Doma, Andrea Grant, Jodie Morris
BACKGROUND: Several studies have examined the effects of balance training in elderly individuals following total knee arthroplasty (TKA), although findings appear to be equivocal. OBJECTIVES: This systematic review and meta-analysis examined the effects of balance training on walking capacity, balance-specific performance and other functional outcome measures in elderly individuals following TKA. METHODS: Data sources: Pubmed, PEDro, Cinahl, SportDiscus, Scopus...
August 16, 2018: Sports Medicine
Algimantas Gaubys, Valdas Papeckys, Mindaugas Pranskunas
Objectives: To overview preclinical animal trials and quantify the effect size that stem cell therapy has on the regeneration of periodontal tissue complex. Material and Methods: A systematic MEDLINE (PubMed) online library search was conducted for preclinical animal studies in vivo , using autologous periodontal ligament, dental pulp, cementum, alveolar periosteal, gingival margin or adipose stem cell types for periodontal tissue complex regeneration purposes. Studies had to be published between 2007...
April 2018: Journal of Oral & Maxillofacial Research
Andrea J Braakhuis, Rohith Nagulan, Vaughan Somerville
Mitochondria are metabolically active organelles that produce significant reactive oxygen species, linked with aging and degenerative diseases. In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging. MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process...
2018: Oxidative Medicine and Cellular Longevity
Sonja Orlovska-Waast, Ole Köhler-Forsberg, Sophie Wiben Brix, Merete Nordentoft, Daniel Kondziella, Jesper Krogh, Michael Eriksen Benros
Infections and inflammatory processes have been associated with the development of schizophrenia and affective disorders; however, no study has yet systematically reviewed all available studies on cerebrospinal fluid (CSF) immune alterations. We aimed to systematically review the CSF immunological findings in schizophrenia spectrum and affective disorders. We identified all studies investigating CSF inflammatory markers in persons with schizophrenia or affective disorders published prior to March 23, 2017 searching PubMed, CENTRAL, EMBASE, Psychinfo, and LILACS...
August 16, 2018: Molecular Psychiatry
George Vaos, Anastasia Dimopoulou, Eleana Gkioka, Nick Zavras
PURPOSE: This study carried out a meta-analysis to compare immediate surgery (IS) with conservative treatment (CT) of complicated acute appendicitis (CAA) in children. METHODS: Systematic literature research was performed for relevant studies published from 1969 to date. Trials of IS compared with CT were included. Outcomes of interest were postoperative morbidity and length of hospital stay (LOS). RESULTS: Fifteen trials were studied (1.243 patients)...
July 27, 2018: Journal of Pediatric Surgery
Qian Tang, Zhi-Chao Hu, Li-Yan Shen, Ping Shang, Hua-Zi Xu, Hai-Xiao Liu
BACKGROUND: The objective of this study was to perform a meta-analysis to investigate the specific relationship between the expression level of circulating adiponectin and osteoarthritis (OA). METHOD: Multiple databases were searched to estimate the high quality of studies relevant to adiponectin and OA. We extracted the data from the eligible studies and included them in the meta-analysis using a random effects model. Subgroup analysis and meta-regression were further performed to explore the potential sources of heterogeneity...
August 16, 2018: Lipids in Health and Disease
Zhi Luo, Zhan Lu, Irfan Muhammad, Yun Chen, Qiuhong Chen, Jiaojiao Zhang, Yongyan Song
BACKGROUND: The associations of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) rs1801133 polymorphism with coronary artery disease (CAD) and plasma lipid levels have been widely investigated, but the results were inconsistent and inconclusive. This meta-analysis aimed to clarify the relationships of the rs1801133 polymorphism with CAD and plasma lipid levels. METHODS: By searching in PubMed, Google Scholar, Web of Science, Cochrane Library, Wanfang, VIP and CNKI databases, 123 studies (87,020 subjects) and 65 studies (85,554 subjects) were identified for the CAD association analysis and the lipid association analysis, respectively...
August 17, 2018: Lipids in Health and Disease
Victor T T Chan, Zihan Sun, Shumin Tang, Li Jia Chen, Adrian Wong, Clement C Tham, Tien Y Wong, Christopher Chen, M Kamran Ikram, Heather E Whitson, Eleonora M Lad, Vincent Mok, Carol Y Cheung
TOPIC: Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimer's Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. CLINICAL RELEVANCE: Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which are non-invasive, technically simple and inexpensive, are potential biomarkers of AD...
August 13, 2018: Ophthalmology
Hiran Thabrew, Karolina Stasiak, Sarah E Hetrick, Stephen Wong, Jessica H Huss, Sally N Merry
BACKGROUND: Long-term physical conditions affect 10% to 12% of children and adolescents worldwide; these individuals are at greater risk of developing psychological problems, particularly anxiety and depression. Access to face-to-face treatment for such problems is often limited, and available interventions usually have not been tested with this population. As technology improves, e-health interventions (delivered via digital means, such as computers and smart phones and ranging from simple text-based programmes through to multimedia and interactive programmes, serious games, virtual reality and biofeedback programmes) offer a potential solution to address the psychological needs of this group of young people...
August 16, 2018: Cochrane Database of Systematic Reviews
Guilherme C Q da Silva, Thiago M Cardozo, Giovanni W Amarante, Charlles R A Abreu, Bruno A C Horta
The kinetics of trichloroacetic acid (TCA) decarboxylation strongly depends on the solvent in which it occurs, proceeding faster in polar aprotic solvents compared to protic solvents. In particular, the reaction is known to be fast in DMSO even at room temperature and is rather slow in water even at higher temperatures. In order to understand the role of the solvent in the kinetics of TCA decarboxylation, the present study investigates this reaction using both ab initio molecular dynamics (AIMD) simulations in explicit solvents and static electronic structure calculations with the SMD polarizable continuum model, considering DMSO and water as solvents...
August 15, 2018: Physical Chemistry Chemical Physics: PCCP
Yulin Liang, Junbo Zou, Xiaofei Zhang, Yu Wang, Jia Tai, Dongyan Guo, Chunli Cui, Jing Wang, Jiangxue Cheng, Yajun Shi
Objective: To evaluate the clinical efficacy and safety of Compound Danshen Dripping Pill (CDDP) and Isosorbide Mononitrate (ISMN) in the treatment of unstable angina pectoris (UAP) in the elderly. Materials and Methods: CNKI, Wanfang, VIP, CBM, and PubMed databases were searched for appropriate articles without language limitations on keywords. RevMan 5.3 software was used to perform the meta-analysis. Results: This analysis compared CDDP with ISMN of 21 randomized controlled trials (RCTs) that involved a total of 2356 patients with UAP...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Zheng Liu, Yu-Ying Sun, Bao-Liang Zhong
BACKGROUND: Caring for people with dementia is highly challenging, and family carers are recognised as being at increased risk of physical and mental ill-health. Most current interventions have limited success in reducing stress among carers of people with dementia. Mindfulness-based stress reduction (MBSR) draws on a range of practices and may be a promising approach to helping carers of people with dementia. OBJECTIVES: To assess the effectiveness of MBSR in reducing the stress of family carers of people with dementia...
August 14, 2018: Cochrane Database of Systematic Reviews
Libo Wang, Jia Li, Jiajun Chen
Background: Levodopa has been widely used and regarded as the most effective therapy for Parkinson's disease (PD), but long-term treatment with oral levodopa may result in motor fluctuations and involuntary movements (dyskinesias). There is evidence to suggest that Continuous infusion of levodopa-carbidopa intestinal gel (LCIG) can effectively manage motor and non-motor complications in PD, but clinical studies investigating this have yielded inconsistent results. This systematic review and meta-analysis was performed to examine the efficacy and safety of LCIG for patients with PD...
2018: Frontiers in Neurology
Ada Ng, Wilson W Tam, Melvyn W Zhang, Cyrus S Ho, Syeda F Husain, Roger S McIntyre, Roger C Ho
We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are significantly higher in elderly with depression and Alzheimer's disease. We searched Pubmed, PsycINFO and Embase, and thirty-four relevant studies (2609 with Depression, 1645 with Alzheimer's disease and 14363 Controls) were included. Compared with controls, IL-1β (pooled standardized mean difference [SMD]: 0...
August 13, 2018: Scientific Reports
Maksim Kouza, Anirban Banerji, Andrzej Kolinski, Irina Buhimschi, Andrzej Kloczkowski
Protein-peptide interactions play essential roles in many cellular processes and their structural characterization is the major focus of current experimental and theoretical research. Two decades ago, it was proposed to employ the steered molecular dynamics (SMD) to assess the strength of protein-peptide interactions. The idea behind using SMD simulations is that the mechanical stability can be used as a promising and an efficient alternative to computationally highly demanding estimation of binding affinity...
August 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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