keyword
https://read.qxmd.com/read/38547510/sulforaphane-improves-redox-homeostasis-and-right-ventricular-contractility-in-a-model-of-pulmonary-hypertension
#1
JOURNAL ARTICLE
Adriana Conzatti, Rafael Colombo, Rafaela Siqueira, Cristina Campos-Carraro, Patrick Turck, Alexandre Luz de Castro, Adriane Belló-Klein, Alex Sander da Rosa Araujo
Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance, imposing overload on the right ventricle (RV) and imbalance of redox state. Our study investigated the influence of treatment with sulforaphane (SFN), found in cruciferous vegetables, on right ventricle (RV) remodeling and redox homeostasis in monocrotaline-induced pulmonary arterial hypertension (PAH). Male Wistar rats were separated into four groups: control (CTR); control + sulforaphane (CTR + SFN); monocrotaline (MCT); monocrotaline + sulforaphane (MCT + SFN)...
March 14, 2024: Journal of Cardiovascular Pharmacology
https://read.qxmd.com/read/38547459/correction-to-prednisone-administration-in-inflammatory-cardiomyopathy-caveat-for-potentially-adverse-myocardial-actions
#2
(no author information available yet)
No abstract text is available yet for this article.
March 28, 2024: European Heart Journal
https://read.qxmd.com/read/38547458/multimodality-imaging-in-a-young-patient-with-antiphospholipid-syndrome-related-acute-myocardial-infarction
#3
JOURNAL ARTICLE
Ibrahim Naoum, Jorge E Schliamser, Keren Zissman, Alexander Fuks, Barak Zafrir
No abstract text is available yet for this article.
March 28, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38547456/weekly-journal-scan-a-hard-rafting-to-improve-long-term-survival-in-heart-failure-with-severely-reduced-ejection-fraction
#4
JOURNAL ARTICLE
Daniela Pedicino, Massimo Volpe
No abstract text is available yet for this article.
March 28, 2024: European Heart Journal
https://read.qxmd.com/read/38547409/long-term-rate-of-ventricular-arrhythmia-in-autoimmune-disease
#5
JOURNAL ARTICLE
Guoli Sun, Emil L Fosbøl, Morten Schou, Mikkel Faurschou, Adelina Yafasova, Jeppe K Petersen, Ketil J Haugan, Ulrik Madvig Mogensen, Jesper H Svendsen, Lars Køber, Jawad H Butt
AIMS: Although selected autoimmune diseases (AIDs) have been linked to an increased risk of ventricular arrhythmias (VAs), data on the long-term rate of VAs across the spectrum of AIDs are lacking. The aim of our study was to investigate the long-term rate of VAs (a composite of ventricular tachycardia, ventricular fibrillation, ventricular flutter, or cardiac arrest) in individuals with a history of 28 different AIDs. METHODS: Individuals diagnosed with an AID (2005-2018) were identified through Danish nationwide registries...
March 28, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38547396/predicting-oncology-drug-induced-cardiotoxicity-with-donor-specific-ipsc-cms-a-proof-of-concept-study-with-doxorubicin
#6
JOURNAL ARTICLE
Li Pang, Chengzhong Cai, Praful Aggarwal, Dong Wang, Vikrant Vijay, Prathyusha Bagam, Jacob Blamer, Andrea Matter, Amy Turner, Lijun Ren, Katy Papineau, Vinodh Srinivasasainagendra, Hemant K Tiwari, Xi Yang, Laura Schnackenberg, William Mattes, Ulrich Broeckel
Many oncology drugs have been found to induce cardiotoxicity in a subset of patients, which significantly limits their clinical use and impedes the benefit of lifesaving anti-cancer treatments. Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carry donor-specific genetic information and have been proposed for exploring the inter-individual difference in oncology drug-induced cardiotoxicity. Herein, we evaluated the inter- and intra- individual variability of iPSC-CM-related assays and presented a proof of concept to prospectively predict doxorubicin (DOX)-induced cardiotoxicity (DIC) using donor-specific iPSC-CMs...
March 28, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38547393/uniportal-video-assisted-thoracic-surgery-segmentectomy-versus-lobectomy-early-outcomes
#7
JOURNAL ARTICLE
Erik Sachs, Veronica Jackson, Mamdoh Al-Ameri, Ulrik Sartipy
OBJECTIVES: To assess the feasibility and safety of uniportal video-assisted thoracoscopic pulmonary segmentectomy compared with lobectomy by studying early postoperative outcomes. METHODS: We included all patients who underwent uniportal segmentectomy and lobectomy between 2017 and 2022 at Karolinska University Hospital. Early clinical outcomes were compared between the uniportal segmentectomy and lobectomy groups. Differences in baseline characteristics were addressed using inverse probability of treatment weighting...
March 28, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38547389/clinical-and-radiological-septic-joint-analysis-of-spontaneous-sternoclavicular-joint-infections-achieving-the-best-outcomes-a-systems-engineering-approach
#8
JOURNAL ARTICLE
Tanushri Pothini, Charles D Wilmot, John K Waters, Michael A Wait, Scott I Reznik, Kirk G Jordan, Jacqueline T Caire, John M Ashworth, Leah C Cady, Jerzy R Lysikowski, Christina F Yen, Robert C Weinschenk, Richard Samade, Michael E Jessen, Andrew Kusiak, Kemp H Kernstine
PURPOSE: Spontaneous sternoclavicular joint infection (SSCJI) is a rare and poorly understood disease process. This study aims to identify factors guiding effective management strategies for SSCJI by using data mining. METHODS: An IRB-approved retrospective review of patients from two large hospitals (2010 to 2022) was conducted. Spontaneous sternoclavicular joint infection is defined as a joint infection without direct trauma or radiation, direct instrumentation, or contiguous spread...
March 28, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38547388/physiological-factors-associated-with-unsatisfied-inspiration-at-peak-exercise-in-healthy-adults
#9
JOURNAL ARTICLE
Olivia N Ferguson, Reid A Mitchell, Michele R Schaeffer, Andrew H Ramsook, Kyle G P J M Boyle, Satvir S Dhillon, Julia Zhang, Alanna S Hind, Dennis Jensen, Jordan A Guenette
INTRODUCTION: Contrary to common belief, a growing body of evidence suggests that unsatisfied inspiration (UI), an inherently uncomfortable quality of dyspnea, is experienced by ostensibly healthy adults during high-intensity exercise. Based on our understanding of the mechanisms of UI among people with chronic respiratory conditions, this analysis tested the hypothesis that the experience of UI at peak exercise in young, healthy adults reflects the combination of high ventilatory demand and critical inspiratory constraints...
March 28, 2024: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/38547372/reverse-cardio-oncology-is-heart-failure-mediated-gut-dysbiosis-the-mechanistic-driver-of-colorectal-cancer-progression
#10
EDITORIAL
Ashraf Yusuf Rangrez, Norbert Frey
No abstract text is available yet for this article.
March 28, 2024: Cardiovascular Research
https://read.qxmd.com/read/38547336/proprotein-convertase-subtilisin-kexin-type-9-inhibition-across-different-patient-populations
#11
JOURNAL ARTICLE
Paulina Elena Stürzebecher, Ulrich Laufs
PURPOSE OF REVIEW: Monoclonal antibodies (mAb) targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have been established in cardiovascular risk prevention. The purpose of this review is to summarize the effects of PCSK9 inhibitors across different patient populations. RECENT FINDINGS: Long-term data on the use of evolocumab and alirocumab shows persisting low- density lipoprotein cholesterol (LDL-C) lowering and good tolerability. PCSK9 inhibitors are effective and safe in both sexes, in pediatric patients as well as in the elderly...
March 28, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38547252/sorbs2-modulation-of-bk-channels-in-arterial-myocytes-implications-for-diabetes
#12
EDITORIAL
L Fernando Santana, Manuel F Navedo
No abstract text is available yet for this article.
March 29, 2024: Circulation Research
https://read.qxmd.com/read/38547251/biological-pacemakers-present-and-future
#13
JOURNAL ARTICLE
Thassio Mesquita, Rodrigo Miguel-Dos-Santos, Eugenio Cingolani
No abstract text is available yet for this article.
March 29, 2024: Circulation Research
https://read.qxmd.com/read/38547250/extracellular-matrix-interactome-in-modulating-vascular-homeostasis-and-remodeling
#14
REVIEW
Yi Fu, Yuan Zhou, Kai Wang, Zhuofan Li, Wei Kong
The ECM (extracellular matrix) is a major component of the vascular microenvironment that modulates vascular homeostasis. ECM proteins include collagens, elastin, noncollagen glycoproteins, and proteoglycans/glycosaminoglycans. ECM proteins form complex matrix structures, such as the basal lamina and collagen and elastin fibers, through direct interactions or lysyl oxidase-mediated cross-linking. Moreover, ECM proteins directly interact with cell surface receptors or extracellular secreted molecules, exerting matricellular and matricrine modulation, respectively...
March 29, 2024: Circulation Research
https://read.qxmd.com/read/38547249/meet-the-first-authors
#15
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 29, 2024: Circulation Research
https://read.qxmd.com/read/38547248/untangling-complexity-gut-microbiota-metabolites-and-fiber-intake-in-type-2-diabetes
#16
EDITORIAL
Nathan T Greenberg, Vienna E Brunt
No abstract text is available yet for this article.
March 29, 2024: Circulation Research
https://read.qxmd.com/read/38547246/gut-microbiota-and-blood-metabolites-related-to-fiber-intake-and-type-2-diabetes
#17
JOURNAL ARTICLE
Zheng Wang, Brandilyn A Peters, Bing Yu, Megan L Grove, Tao Wang, Xiaonan Xue, Bharat Thyagarajan, Martha L Daviglus, Eric Boerwinkle, Gang Hu, Yasmin Mossavar-Rahmani, Carmen R Isasi, Rob Knight, Robert D Burk, Robert C Kaplan, Qibin Qi
BACKGROUND: Consistent evidence suggests diabetes-protective effects of dietary fiber intake. However, the underlying mechanisms, particularly the role of gut microbiota and host circulating metabolites, are not fully understood. We aimed to investigate gut microbiota and circulating metabolites associated with dietary fiber intake and their relationships with type 2 diabetes (T2D). METHODS: This study included up to 11 394 participants from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos)...
March 29, 2024: Circulation Research
https://read.qxmd.com/read/38547172/clusters-of-longitudinal-risk-profile-trajectories-are-associated-with-cardiometabolic-diseases-results-from-the-population-based-kora-cohort
#18
JOURNAL ARTICLE
Fiona Niedermayer, Gunther Schauberger, Wolfgang Rathmann, Stefanie J Klug, Barbara Thorand, Annette Peters, Susanne Rospleszcz
BACKGROUND: Multiple risk factors contribute jointly to the development and progression of cardiometabolic diseases. Therefore, joint longitudinal trajectories of multiple risk factors might represent different degrees of cardiometabolic risk. METHODS: We analyzed population-based data comprising three examinations (Exam 1: 1999-2001, Exam 2: 2006-2008, Exam 3: 2013-2014) of 976 male and 1004 female participants of the KORA cohort (Southern Germany). Participants were followed up for cardiometabolic diseases, including cardiovascular mortality, myocardial infarction and stroke, or a diagnosis of type 2 diabetes, until 2016...
2024: PloS One
https://read.qxmd.com/read/38547158/management-of-hypertension-in-heart-transplant-recipients-an-ongoing-conundrum
#19
JOURNAL ARTICLE
Juan Duarte Torres, Selim R Krim
PURPOSE OF REVIEW: Hypertension remains one of the most common clinical problems leading to significant posttransplant complications. This study reviews the pathophysiology of hypertension in the postcardiac transplant phase and provides an update on currently available antihypertensive therapies for heart transplant patients. RECENT FINDINGS: The true prevalence of hypertension in the heart transplant population remains unknown. Effective blood pressure (BP) control is key to prevent left ventricular remodeling, diastolic dysfunction and stroke...
March 28, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38547148/recent-updates-on-therapeutic-targeting-of-lipoprotein-a-with-rna-interference
#20
JOURNAL ARTICLE
Aravind Sekhar, Ashani Kuttan, Richard A Lange
PURPOSE: RNA interference (RNAi)-based therapies that target specific gene products have impacted clinical medicine with 16 FDA approved drugs. RNAi therapy focused on reducing plasma lipoprotein(a) [Lp(a)] levels are under evaluation. FINDINGS: RNAi-based therapies have made significant progress over the past 2 decades and currently consist of antisense oligonucleotides (ASO) and small interfering RNA (siRNA). Chemical modification of the RNA backbone and conjugation of siRNA enables efficient gene silencing in hepatocytes allowing development of effective cholesterol lowering therapies...
March 27, 2024: Current Opinion in Cardiology
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