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A J Scheen, C Mathieu
Xultophy® (IDegLira) is a fixed ratio combination of basal insulin degludec and glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide. Insulin degludec is characterized by an original mode of prolonged and continuous insulin diffusion after its subcutaneous injection. Thereby, it has a very long half-life, around 25 hours, and a better reproducibility from both a pharmacokinetic and pharmacodynamic point of view, with less hypoglycaemia, especially at night. Liraglutide is a well-known once-daily GLP-1 receptor agonist that showed a cardiovascular and renal protection in patients with type 2 diabetes at high cardiovascular risk...
October 2018: Revue Médicale de Liège
G Résimont, R Gadisseur, L Lutteri, J M Krzesinski, E Cavalier, P Delanaye
The measurement of proteinuria is a very simple tool to screen and manage kidney diseases. Its predictive role is also relevant from a cardiovascular point of view. However, the interpretation of the results is not always easy. Indeed, there are several different methods to detect or measure proteinuria (or albuminuria), varying from the measurement on a 24-hour urine collection to the simplest detection with dipsticks or measurement on a random urine sample. Some methods are measuring total proteins, whereas others are measuring more specifically albuminuria...
October 2018: Revue Médicale de Liège
S Systermans, P Paulus, A Bruwier, Y Gilon
Obstructive Sleep Apnea Syndrome (OSAS) is a common underdiagnosed pathology. Its consequences are serious, especially in terms of quality of life and cardiovascular risk. This article describes the case of a patient having a severe OSAS. The conservative treatments as well as uvulopalatopharyngoplasty did not improve the symptomatology in an acceptable way. This clinical case illustrates the effectiveness of maxillomandibular advancement for patients with severe OSAS who respond poorly to conservative treatments...
October 2018: Revue Médicale de Liège
O D Ostroumova, M S Cherniaeva
This article presents a review of Russian and foreign literature about the impact of arterial hypertension (AH) on the risk of cognitive impairment and dementia. Large studies have demonstrated the effect of blood pressure (BP) on the risk of vascular dementia and Alzheimer's disease (AD) in elderly and oldest old people as well as a role of antihypertensive therapy. There is evidence of a negative effect of hypertension in middle age on cognitive functions in late-life. Observational studies as a whole have shown the positive effect of antihypertensive therapy on the prevention of cognitive function and dementia...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Tomasz Roleder, Michał Hawranek, Tomasz Gąsior, Daniel Cieśla, Marian Zembala, Wojciech Wojakowski, Mariusz Gąsior, Zbigniew Gąsior
Introduction During the last decade, aortic stenosis (AS) has emerged as one of the most significant subjects in cardiovascular diseases. Objectives The following study extracted data from the local registry to present the characteristics of AS patients. Patients and methods The report referred to the SILCARD database, which is based on the agreement between Silesian Centre for Heart Diseases in Zabrze and the Regional Department of National Health Fund in Katowice to conduct a comprehensive analysis of patients with cardiovascular diseases in the Silesian Province...
October 18, 2018: Polish Archives of Internal Medicine
Jae-Hyun Kim
After the implementation of a policy differentiating inpatient nursing fees, no study is found in the nursing literature for intensive care unit (ICU) patients admitted with cardiovascular (CV) disease exclusively in Korea. This study investigates the relationship between ICU nurse staffing and 30-day mortality using large representative claim database.National Health Insurance Service-Senior (NHIS-Senior) claim database from 2002 to 2013, which was released by the Korean National Health Insurance Service (KNHIS), was used in this study...
October 2018: Medicine (Baltimore)
Peng Cai, Yan Peng, Yan Wang, Xukai Wang
BACKGROUND: White-coat hypertension (WCH) is a debatable risk factor of cardio-cerebrovascular diseases and the current study results on the association between WCH and arterial stiffness are inconsistent. The aim was to investigate the effect of WCH on arterial stiffness using meta-analysis. METHODS: Based on prespecified search strategies and inclusion criteria, Medline, Embase, Web Of Science, Cochrane Library, and BioSciences Information Service Preview databases were reviewed...
October 2018: Medicine (Baltimore)
Hongyu Kuang, Xue Zhou, Li Li, Qijian Yi, Weinian Shou, Tiewei Lu
RATIONALE: Familial hypercholesterolemia (FH) is a common inherited cause of coronary heart disease (CHD) and premature death in an early age. Nevertheless, an ischemic heart failure (IHF) associated with FH seems to be rare, and an early diagnosis and therapy could influence the prognosis. PATIENT CONCERNS: In this 13-year-old girl, multiple xanthomas began to develop from the first day of birth. Until June, 2017, she was admitted to our center due to edema, oliguria, and dyspnea during exertion, which was attributed to a recent respiratory infection...
October 2018: Medicine (Baltimore)
Jun Shimizu, Yoshihisa Yamano, Kimito Kawahata, Noboru Suzuki
Relapsing polychondritis (RP) is a multisystem disorder of cartilaginous tissues. Previously, we found that patients with respiratory involvement and patients with auricular involvement were mutually exclusive in the RP cohort, which suggests a strong inverse relationship between respiratory and auricular involvement. Here, we examined the clinical manifestation patterns in a subgroup of patients with respiratory involvement (R subgroup) and a subgroup of patients with auricular involvement (A subgroup) and investigated the clinical and laboratory characteristics of each subgroup...
October 2018: Medicine (Baltimore)
Chunghee Joo, Joo-Won Min, Giyong Noh, Jaeho Seo
INTRODUCTION: Aortic dissection is a very rare but life-threatening condition associated with a high mortality. Unexpected sudden cardiac death due to aortic rupture following laparoscopic appendectomy is very rare and may be difficult to diagnose. However, early diagnosis of aortic dissection is essential for the timely treatment and outcome of aortic dissection. CASE PRESENTATION: A 50-year-old man underwent a laparoscopic appendectomy. Postoperatively, the patient complained of dyspnea and chest pain...
October 2018: Medicine (Baltimore)
Jae-Hyung Roh, Young-Hak Kim, Hee Jun Kang, Pil Hyung Lee, Sung-Han Yoon, Mineok Chang, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
This study aimed to investigate the feasibility and safety of the modified balloon crush technique.The conventional crush technique accompanies difficult and suboptimal final kissing balloon inflation (FKI)In a single-center percutaneous coronary intervention registry, 515 patients with 515 bifurcation lesions were treated with the modified balloon technique (n = 70) or the conventional crush technique (n = 445). In contrast to the conventional crush technique, where the implanted side branch (SB) stent is crushed by expansion of the main branch (MB) stent, the modified balloon crush technique uses balloon crushing and additional SB ballooning across the crushed SB stent before MB stenting to facilitate FKI...
October 2018: Medicine (Baltimore)
Jason P Burnham, Rebecca P Rojek, Marin H Kollef
Central-line-associated bloodstream infections (CLABSIs) are responsible for ∼1/3 of all deaths from healthcare-associated infections in the United States. Of these, multidrug-resistant organisms (MDROs) are responsible for 20% to 67%. However, whether catheter removal affects clinical outcomes for MDRO CLABSIs has not been studied. Our objective was to determine the relationship between failure to remove a central venous catheter (CVC) and 30-day all-cause mortality in patients with MDRO CLABSIs. We used a retrospective cohort from Barnes-Jewish Hospital (1/1/2009-10/1/2015) to study patients with a multidrug-resistant Staphylococcus aureus, Enterococcus species, Enterobacteriaceae, Acinetobacter species, or Pseudomonas aeruginosa CLABSI...
October 2018: Medicine (Baltimore)
Chen-Jan Chiu, Chih-Wen Chi, Hui-Ru Hsieh, Yu-Chuen Huang, Huey-June Wu, Yu-Jen Chen
The aim of this study was to examine the effect of the level-1 Yo-Yo intermittent recovery test (YYIRT1) on polarization of macrophages in young football players.Fourteen male football players (19.9 ± 1.4 years old) were enrolled in this study. YYIRT1 was performed with 20-meter shuttle runs at increasing speeds and 10-second active recovery in a 5-meter distance between runs till exhaustion. Fasting blood samples were collected before and immediately after YYIRT1. Analysis for macrophage polarization by flow cytometry, reactive oxygen species (ROS) by flow cytometry, biochemical parameters by chemical reactions, and serum cytokines by ELISA were performed...
October 2018: Medicine (Baltimore)
Mojtaba Nouhi, Mohamad Hadian, Alireza Olyaeemanesh
BACKGROUND: Surgical intervention is one of the common therapeutic interventions applied to a vast class of diseases. Unwarranted variation in practice style in different locations is considered as practice style variations (PSVs), which cause undesirable effects on patient health status and economic consequences. The magnitude of the variations in surgical interventions and its effects on clinical outcomes of patients and also utilization of resources have been investigated in recent years...
October 2018: Medicine (Baltimore)
Fay H Johnston, Farhad Salimi, Grant J Williamson, Sarah B Henderson, Jiayun Yao, Martine Dennekamp, Karen Smith, Michael J Abramson, Geoffrey G Morgan
BACKGROUND: Ambulance data provide a useful source of population-based and spatiotemporally resolved information for assessing health impacts of air pollution in non-hospital settings. We used the clinical records of paramedics to quantify associations between PM2.5 and diabetic, cardiovascular, and respiratory conditions commonly managed by those responding to calls for emergency ambulance services. METHODS: We evaluated 394,217 paramedic assessments from three states in Southeastern Australia (population 13...
October 16, 2018: Epidemiology
Alexander Dastrup, Anton Pottegård, Jesper Hallas, Søren Overgaard
BACKGROUND: There have been concerns that the antifibrinolytic drug tranexamic acid (TXA) might increase the postoperative risk of cardiovascular events. Our objective was to determine whether perioperative TXA use is associated with cardiovascular events and death within 30 days after primary total hip arthroplasty (THA). METHODS: We conducted a nationwide cohort study of cardiovascular outcomes after perioperative exposure to tranexamic acid during THA. We included 45,290 patients who had a THA in the study period of 2006 to 2013; 38,586 received perioperative TXA, and 6,704 did not...
October 17, 2018: Journal of Bone and Joint Surgery. American Volume
Carl G Streed, Zil Goldstein, Tonia Poteat, Monica Mukherjee, Asa Radix
No abstract text is available yet for this article.
October 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Guilherme Pinheiro Machado, Gustavo N Araujo, Christian K Carpes, Mateus C Lech, Stefani Mariani, Felipe H Valle, Luiz C C Bergoli, Rodrigo V Wainstein, Marco V Wainstein
BACKGROUND: Elevated neutrophil-to-lymphocyte ratio (NLR) is an indirect marker of inflammation, and is associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to investigate the usefulness of NLR to predict procedural adverse events is patients who underwent primary percutaneous coronary intervention (PCI). PATIENTS AND METHODS: Consecutive patients with STEMI who underwent primary PCI were divided into low and high NLR, whereas high was defined as an NLR value above 75° percentile (≥9...
October 16, 2018: Coronary Artery Disease
Taian Vieira, Giacinto Luigi Cerone, Laura Gastaldi, Stefano Pastorelli, Liliam F Oliveira, Marco Gazzoni, Alberto Botter
Functional electrical stimulation of lower limb muscles during rowing provides a means for the cardiovascular conditioning in paraplegia. The possibility of shaping stimulation profiles according to changes in knee angle, so far conceived as changes in seat position, may help circumventing open issues associated with muscle fatigue and movement coordination. Here we present a subject-specific biomechanical model for the estimation of knee joint angle during indoor rowing. Anthropometric measurements and foot and seat position are inputs to the model...
October 17, 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
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