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Igor Nasser, Jeffrey Willardson, Renata de Mello Perez, Michel Silva Reis, Anderson de Azevedo Brito, Ingrid Ferreira Dias, Humberto Lameira Miranda
The purpose of this study was to analyze and compare heart rate (HR), heart rate variability (HRV), and blood pressure (BP) responses during and after circuit resistance training with 1 min. (CIR1) vs. 2 min. (CIR2) rest intervals between exercises in liver cirrhosis patients. 10 patients (7 women, 3 men) participated in 2 experimental sessions (CIR1 and CIR2) in random order. Each experimental session consisted of 6 exercises performed for 3 sets of 10 repetitions with 70% of the 10-RM load. The only difference between experimental sessions was taking either 1 min...
December 17, 2018: International Journal of Sports Medicine
Christian Albert, Johanna Kube, Annemarie Albert, Denny Schanze, Martin Zenker, Peter R Mertens
AIM: Aim of this study was to investigate the association of genetic variants of functional polymorphisms of matrix metalloproteinase and Cubilin (CUBN) with diabetic nephropathy (DN), end-stage renal disease (ESRD), and risk of cardiovascular disease (CVD) in Caucasian type 2 diabetes (T2D) patients. METHODS: 472 T2D-patients were genotyped for 3 single-nucleotide polymorphisms (SNPs; MMP-2 [rs2285053], MMP-9 [rs17576] and CUBN [rs1801239]). Genotyping was carried out by allelic discrimination using TaqMan SNP-genotyping-assay...
December 17, 2018: Nephron
Yi-Cheng Chang, Chia-Hsuin Chang, Yi-Ting Huang, Yi-Chun Yeh, Meng-Lun Hsieh, Wei-Shun Yang, Yu-Kang Tu
BACKGROUND: Extensive studies have demonstrated that sleep is an important modulator of cardiovascular and metabolic diseases. However, its impact on renal function remains uncertain. METHODS: A total of 26,249 adults aged ≥20 years were recruited through voluntary health examinations in Taiwan. Sleep duration was self-reported by questionnaire. Proteinuria was graded semi-quantitatively by dipstick urine test. The associations of sleep duration with proteinuria and estimated glomerular filtration rate (eGFR) were analyzed...
December 17, 2018: American Journal of Nephrology
Malena P Pantou, Polyxeni Gourzi, Aggeliki Gkouziouta, Dimitrios Tsiapras, Christianna Zygouri, Pantelis Constantoulakis, Stamatis Adamopoulos, Dimitrios Degiannis
OBJECTIVE: We present the genotypic and phenotypic characterization of a family displaying dilated cardiomyopathy (DCM). METHODS: The proband and his relatives underwent full cardiological assessment. Genetic analysis of the proband was performed with the use of next-generation sequencing technology. RESULTS: In this study, we present 6 members of a family carrying the RBM20 mutation NM_001134363.2:c.1900C>T. The proband was initially diagnosed with DCM at the age of 18 years and received an implantable cardioverter defibrillator (ICD) due to ventricular arrhythmias...
December 17, 2018: Cardiology
Saurav Islam, Shruti Shukla, Vivek K Bajpai, Young-Kyu Han, Yun Suk Huh, Ashok Kumar, Arindam Ghosh, Sonu Gandhi
Human immunodeficiency virus (HIV), which isa worldwide public health issue, is commonly associated with cardiovascular disorders (CVDs) and rheumatoid arthritis (RA). A smart nanosensor was developed for the detection of HIV and its related diseases (CVDs and RA) using graphene-based field-effect transistors (FETs). In this study, amine-functionalized graphene (afG) was conjugated with antibodies [anti-p24 for HIV, anti-cardiac troponin 1 (anti-cTn1) for CVDs, and anti-cyclic citrullinated peptide (anti-CCP) for RA] to detect various biomarkers...
December 7, 2018: Biosensors & Bioelectronics
Tolulope Eniola Omolekulo, Olugbenga Samuel Michael, Lawrence Aderemi Olatunji
Dipeptidyl peptidase-4 (DPP-4) inhibition has been shown to exert beneficial effects against insulin resistance (IR) and type 2 diabetes. Combined oral contraceptive (COC) treatment is associated with impaired glucose and lipid metabolism but the mechanisms are elusive. We therefore, hypothesized that DPP-4 inhibition ameliorates COC-induced glucose dysregulation and hepatic triglyceride (TG) accumulation through adenosine deaminase (ADA) /xanthine oxidase (XO) /uric acid-dependent pathway. Female Wistar rats received (po) vehicle and COC (1...
December 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Bo-Yi Yang, Yuming Guo, Lidia Morawska, Michael S Bloom, Iana Markevych, Joachim Heinrich, Shyamali C Dharmage, Luke D Knibbs, Shao Lin, Steve Hung-Lam Yim, Gongbo Chen, Shanshan Li, Xiao-Wen Zeng, Kang-Kang Liu, Li-Wen Hu, Guang-Hui Dong
BACKGROUNDS: Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5 ) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM1 (≤1.0 μm) size fraction and CVD. We investigated the associations between PM1 and PM2.5 and CVD prevalence in Chinese adults. METHODS: In 2009, we randomly recruited 24,845 adults at the age of 18-74 years from 33 communities in Northeastern China...
December 14, 2018: Environment International
Alexandrine Robert, Tiphaine Monsinjon, Romain Péden, Virginie Rasoamampianina, Jean-Claude Le Mével, Thomas Knigge
Serotonin (5-HT) takes a key position in regulating vital functions, such as cardio-ventilatory activity, locomotion and behaviour. Selective serotonin reuptake inhibitors (SSRIs) modulate the serotonergic system and thus affect these functions. Rhythmic behaviours, such as cardio-ventilatory activity, are controlled by central pattern generators, which in turn are regulated by 5-HT. In crustaceans, 5-HT also regulates the synthesis and secretion of crustacean hyperglycaemic hormone, a pleiotropic hormone involved in the mobilisation and release of glucose into the haemolymph, thus stimulating the animal's activity...
December 5, 2018: Aquatic Toxicology
Jiading Li, Cong Liu, Yuexin Cheng, Shumei Guo, Qian Sun, Lena Kan, Renjie Chen, Haidong Kan, Hongjian Bai, Jingyan Cao
BACKGROUND: Abundant epidemiological studies have revealed that short-term exposure to ambient air pollution increased the incidence of ischemic heart diseases. However, few investigations have explored the association between air pollution and ST-elevation myocardial infarction (STEMI), one major subtype of such events. METHODS: We conducted a time-stratified case-crossover study in two major hospitals of Yancheng, a city in East China, from January 2015 to February 2018...
December 12, 2018: Chemosphere
Julie C Krzykwa, Asal Saeid, Marlo K Sellin Jeffries
Fish embryos are increasingly being utilized in aquatic toxicity testing, as evidenced by the Organisation for Economic Co-operation and Development's approval of the fish embryo acute toxicity (FET) test. However, the FET test only allows for the estimation of acute toxicity, whereas other test methods such as the larval growth and survival (LGS) test allow for the estimation of both acute and chronic toxicity. Additionally, it has been demonstrated that the FET test is less sensitive than other test methods for some neurotoxic compounds...
December 14, 2018: Ecotoxicology and Environmental Safety
Lisa M McKenzie, James Crooks, Jennifer L Peel, Benjamin D Blair, Stephen Brindley, William B Allshouse, Stephanie Malin, John L Adgate
BACKGROUND: Oil and natural gas (O&G) extraction emits pollutants that are associated with cardiovascular disease, the leading cause of mortality in the United States. OBJECTIVE: We evaluated associations between intensity of O&G activity and cardiovascular disease indicators. METHODS: Between October 2015 and May 2016, we conducted a cross-sectional study of 97 adults living in Northeastern Colorado. For each participant, we collected 1-3 measurements of augmentation index, systolic and diastolic blood pressure (SBP and DBP), and plasma concentrations of interleukin (IL)- 1β, IL-6, IL-8 and tumor necrosis factor alpha (TNF-α)...
December 6, 2018: Environmental Research
Sarah Rajkumar, Bonnie N Young, Maggie L Clark, Megan L Benka-Coker, Annette M Bachand, Robert D Brook, Tracy L Nelson, John Volckens, Stephen J Reynolds, Christian L'Orange, Nicholas Good, Kirsten Koehler, Sebastian Africano, Anibal B Osorto Pinel, Jennifer L Peel
BACKGROUND: Household air pollution from cooking with solid fuels affects nearly 3 billion people worldwide and is responsible for an estimated 2.5 million premature deaths and 77 million disability-adjusted life years annually. Investigating the effect of household air pollution on indicators of cardiometabolic disease, such as metabolic syndrome, can help clarify the pathways between this widespread exposure and cardiovascular diseases, which are increasing in low- and middle-income countries...
December 10, 2018: Environmental Research
Luciana L Ferreira, Teresa Cunha-Oliveira, Caroline D Veloso, Cláudio F Costa, Kendall B Wallace, Paulo J Oliveira
Dose-dependent and cumulative cardiotoxicity associated with doxorubicin (DOX) is the main limitation of anticancer therapy. Pediatric cancer survivors are particularly vulnerable, and no effective prevention measures are available. The aim of the present study was to investigate the persistent effects of nanomolar DOX concentrations and determine whether a pretreatment would induce mitochondrial adaptations in H9c2 cardiomyoblasts. H9c2 cells were incubated with DOX (10 and 25 nM) for 24 h, followed by 9 days of recovery in drug-free medium...
December 14, 2018: Food and Chemical Toxicology
Owen A Williams, Yang An, Lori Beason-Held, Yuankai Huo, Luigi Ferrucci, Bennett A Landman, Susan M Resnick
White matter microstructure can be measured with diffusion tensor imaging (DTI). While increasing age is a predictor of white matter (WM) microstructure changes, roles of other possible modifiers, such as cardiovascular risk factors, APOE ε4 allele status and biological sex have not been clarified. We investigated 665 cognitively normal participants from the Baltimore Longitudinal Study of Aging (age 50-95, 56.7% female) with a total of 1384 DTI scans. WM microstructure was assessed by fractional anisotropy (FA) and mean diffusivity (MD)...
December 14, 2018: NeuroImage
Julian Mustroph, Simon Lebek, Lars S Maier, Stefan Neef
Ethanol can acutely and chronically alter cardiomyocyte and whole-organ function in the heart. Importantly, ethanol acutely and chronically predisposes to arrhythmias, while chronic abuse can induce heart failure. However, the molecular mechanisms of ethanol toxicity in the heart are incompletely understood. In this review, we summarize the current mechanistic knowledge on cardiac ethanol toxicity, with a focus on druggable pathways. Ethanol effects on excitation-contraction coupling, oxidative stress, apoptosis, and cardiac metabolism, as well as effects of ethanol metabolites will be discussed...
December 14, 2018: Pharmacology & Therapeutics
Dongsheng Lei, Yadong Yu, Yu-Lin Kuang, Jianfang Liu, Ronald M Krauss, Gang Ren
Intermediate-density lipoproteins (IDLs), the remnants of very-low-density lipoproteins via lipolysis, are rich in cholesteryl ester and are correlated with cardiovascular disease. Despite pharmacological interests in IDL, the three-dimensional (3D) structure of IDLs is still undetermined due to their variation in size, compositions, and dynamic structure. To explore the 3D structure of IDL, we reconstructed 3D density maps from each individual IDL particles using cryo-electron microscopy (cryo-EM) and individual-particle electron tomography (IPET, without averaging from different molecules)...
December 14, 2018: Biochimica et biophysica acta. Molecular and cell biology of lipids
Shouguo Liu, Jan D Reinhardt, Xia Zhang, Cristina Ehrmann, Wenzhi Cai, Birgit Prodinger, Shan Liu, Jianan Li
OBJECTIVE: To validate the ICF Generic-6 in daily routine clinical practice in Mainland China. Specific objectives were to a) analyse the interrater reliability, b) convergent validity, c) known group validity and d) predictive validity of the ICF Generic-6. DESIGN: Multi-centre prospective cohort study. SETTING: 50 hospitals from 20 provinces of Mainland China. PARTICIPANTS: 4510 patients from departments of Rehabilitation, Orthopaedics, Neurology, Cardiology, Pneumology, and Cerebral Surgery of the participating hospitals with different health condition were included in this study...
December 14, 2018: Archives of Physical Medicine and Rehabilitation
Lydia L M Lytle, Jennifer L Dannenbring, Matthew A Kilgas, Steven J Elmer
OBJECTIVE: We compared metabolic, cardiorespiratory, and perceptual responses to acute eccentric (ECCarm ) and traditional concentric (CONarm ) arm cycling in a cohort of wheelchair users. DESIGN: Single-group repeated measures. SETTING: Exercise physiology laboratory. PARTICIPANTS: A convenience sample of seven manual wheelchair users (45±15yrs; 87±21kg; 1.8±0.1m; time in wheelchair 17±14yrs) volunteered. INTERVENTIONS: Participants performed 5min trials of eccentric and concentric arm cycling at 1) iso-metabolic rate (35% of peak oxygen consumption) and 2) iso-power output (80W)...
December 14, 2018: Archives of Physical Medicine and Rehabilitation
Eman M Alissa, Layla S Alzughaibi, Zuhair M Marzouki
AIMS: The convergence of obesity and inflammation in the pathogenesis of cardiovascular diseases (CVD) has been recognized over the past decade. Resistin has emerged as a novel secreted protein with links to both insulin resistance and inflammation. We aimed to investigate the relationship between changes in serum resistin levels with metabolic parameters, including obesity and inflammatory markers in women free of CVD. METHODS AND RESULTS: A total of 200 apparently healthy women were consecutively recruited from the Out-patients Clinics at King Abdulaziz university Hospital in Jeddah, Saudi Arabia...
December 14, 2018: Chemistry and Physics of Lipids
Mark K Ferguson, Kristen Wroblewski, Megan Huisingh-Scheetz, Katherine Thompson, Jeanne Farnan
BACKGROUND: Physician gender differences exist for estimating surgical risk and recommending lung resection. We assessed gender differences in perceived importance of health characteristics portrayed by standardized patients posing as lung resection candidates. METHODS: Physicians read a clinical vignette categorized as low, average, or high surgical risk, then viewed a video of a standardized patient exhibiting vigorous, normal, or frail behavior. The relative importance of gait speed, strength, fatigue, age, and weight loss in the videos was scored on a 5-point Likert-like scale...
December 14, 2018: Annals of Thoracic Surgery
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