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Intrauterine restriction growth

Ali Alhousseini, Sunil Jaiman, Edgar Hernandez-Andrade, Salam Zeineddine, Faisal Qureshi, Suzanne M Jacques
Background: Thrombosis of one of the umbilical arteries can be associated with adverse pregnancy outcomes such as stillbirth and severe intrauterine growth restriction (IUGR). Case: A 21-year-old gravida 1 patient, with a history of 3-vessel cord at 20 weeks, presented at 29 weeks with a single umbilical artery. The estimated fetal weight measurements at 26 weeks, 29 weeks, and 31 weeks were at the 27th percentile, the 26th percentile, and less than the 5th percentile, respectively...
2018: Case Reports in Obstetrics and Gynecology
M B Tenório, R C Ferreira, F A Moura, N B Bueno, M O F Goulart, A C M Oliveira
AIMS: To determine whether oral antioxidant therapies, of various types and doses, are able to prevent or treat women with preeclampsia. DATA SYNTHESIS: The following databases were searched: MEDLINE, CENTRAL, LILACS, and Web of Science. Inclusion criteria were: a) randomized clinical trials; b) oral antioxidant supplementation; c) study in pregnant women; d) control group, treated or not with placebo. Papers were excluded if they evaluated antioxidant nutrient supplementation associated with other non-antioxidant therapies...
September 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Ramkumar Mohan, Daniel C Baumann, Emilyn U Alejandro
The prevalence of obesity and type 2 (T2D) diabetes is a major health concern in the United States and around the world. T2D is a complex disease characterized by pancreatic β-cell failure in association with obesity and insulin resistance in peripheral tissues. Although several genes associated with T2D have been identified, it is speculated that genetic variants account for only less than 10% of the risk for this disease. A strong body of data from both human epidemiological and animal studies shows that fetal nutrient factors in utero confer significant susceptibility to T2D...
August 15, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Cetewayo S Rashid, Amita Bansal, Rebecca A Simmons
Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and oxidative stress are commonly found in key tissues (pancreatic islets, liver, and skeletal muscle) of IUGR individuals. In this review, we explore the role of oxidative stress in IUGR-associated diabetes etiology.
September 1, 2018: Physiology
Gregory Costain, Michal Inbar-Feigenberg, Maha Saleh, Shimrit Yaniv-Salem, Greg Ryan, Eric Morgen, Elaine S Goh, Gen Nishimura, David Chitayat
Traditional approaches to prenatal genetic diagnosis for common presentations such as short femurs or intrauterine growth restriction are imperfect, and whole-exome sequencing is an emerging option. Mucolipidosis type II (I-cell disease) is an ultra-rare autosomal recessive lysosomal storage disorder with the potential for prenatal-onset skeletal and placental manifestations. We describe the prenatal signs in two recent unrelated patients with confirmed diagnoses soon after birth. In both cases, parents were consanguineous but there was no known family history of mucolipidosis type II...
September 2018: Journal of Pediatric Genetics
Konstantinos Nirgianakis, Maria Luisa Gasparri, Anda-Petronela Radan, Anna Villiger, Brett McKinnon, Beatrice Mosimann, Andrea Papadia, Michael D Mueller
OBJECTIVE: To study obstetric outcomes and complications in women with previously excised posterior deep infiltrating endometriosis (DIE) in comparison with women without endometriosis. DESIGN: Matched case-control study. SETTING: Tertiary-level academic center. PATIENT(S): All surgeries for endometriosis performed in the Department of Gynecology and Gynecological Oncology, University of Bern between March 2004 and July 2015, were assessed...
August 2018: Fertility and Sterility
Sonnet S Jonker, Samantha Louey, Charles E Roselli
Polycystic ovary syndrome (PCOS) is a complex and common disorder in women, and those affected experience an increased burden of cardiovascular disease. It is an intergenerational syndrome, as affected women with high androgen levels during pregnancy "program" fetal development, leading to a similar phenotype in their female offspring. The effect of excess maternal testosterone exposure on fetal cardiomyocyte growth and maturation is unknown. METHODS Pregnant ewes received biweekly injections of vehicle (Control) or 100 mg testosterone propionate between 30-59 days of gestation (dGA; Early T) or 60-90 dGA (Late T)...
August 10, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Yao-Lung Chang, An-Shine Chao, Hsiu-Huei Peng, Shuenn-Dyh Chang, Kuan-Ju Chen, Po-Jen Cheng, Tzu-Hao Wang
BACKGROUND: We previously reported that fetal plasma erythropoietin (EPO) concentrations are significantly increased in growth-restricted fetuses with abnormal umbilical artery (UA) Doppler. During hypoxia in an ovine model, the primary site of fetal EPO synthesis was switched from the kidneys to the placenta. Therefore, we designed this study to evaluate human placental EPO gene expression and the correlation to fetal serum EPO concentration in growth-restricted fetuses in a monochorionic (MC) twin model...
August 8, 2018: BMC Pregnancy and Childbirth
Tsai-Der Chuang, Reiko Sakurai, Ming Gong, Omid Khorram, Virender K Rehan
Considerable epidemiological and experimental evidence supports the concept that the adult chronic lung disease (CLD), at least in part, is due to aberrations in early lung development in response to an abnormal intrauterine environment; however, the underlying molecular mechanisms remain unknown. We used a well-established rat model of maternal undernutrition (MUN) during pregnancy that results in offspring intrauterine growth restriction (IUGR) and adult CLD to test the hypothesis that excess maternal glucocorticoids in response to MUN programs offspring lung development to a CLD phenotype by altering miRNA (miR)-29 expression, which is a key miR in regulating extracellular matrix (ECM) deposition during development and injury-repair...
August 8, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Hong Song, Bhanu P Telugu, Loren P Thompson
Placental hypoxia can stimulate oxidative stress and mitochondrial dysfunction reducing placental efficiency and inducing fetal growth restriction (FGR). We hypothesized that chronic hypoxia inhibits mitochondrial function in the placenta as an underlying cause of cellular mechanisms contributing to FGR. Pregnant guinea pigs were exposed to either normoxia (NMX) or hypoxia (HPX; 10.5%O2) at 25d gestation until term (65d). Guinea pigs were anesthetized, and fetuses and placentas were excised at either mid (40d) or late gestation (64d), weighed, and placental tissue stored at -80°C until assayed...
July 31, 2018: Biology of Reproduction
Karina L Arce-López, Juan Vicencio-Rivas, José Iglesias-Leboreiro, Isabel Bernárdez-Zapata, Mario E Rendón-Macías, Ariela Braverman-Bronstein
Introducción: El bajo peso neonatal (< 2.5 kg o < percentil 10) se atribuye a causas constitucionales (pequeño para la edad gestacional [PEG]) o a la restricción en el crecimiento intrauterino (RCIU), con riesgos posnatales diferentes. En ausencia de una valoración fetal-placentaria prenatal adecuada, resulta difícil establecerlo. El conocer los antecedentes maternos de enfermedades gestacionales (AMEG): hipertensión arterial (HTA), hipotiroidismo, Diabetes Mellitus (DM) gestacional y otra; pudiera orientar a la diferenciación y el manejo...
2018: Boletín Médico del Hospital Infantil de México
I M Beune, A Pels, S J Gordijn, W Ganzevoort
Fetal growth restriction (FGR) is a major health problem because it has a significant contribution to perinatal mortality and morbidity.(1, 2) Long-term health outcomes, such as neurological- and cognitive development, cardiovascular and endocrine diseases, are negatively influenced by an adverse intrauterine environment.(3) This article is protected by copyright. All rights reserved.
August 5, 2018: Ultrasound in Obstetrics & Gynecology
Sandra Haider, Gudrun Meinhardt, Leila Saleh, Viktoria Kunihs, Magdalena Gamperl, Ulrich Kaindl, Adolf Ellinger, Thomas R Burkard, Christian Fiala, Jürgen Pollheimer, Sasha Mendjan, Paulina A Latos, Martin Knöfler
Defective placentation is the underlying cause of various pregnancy complications, such as severe intrauterine growth restriction and preeclampsia. However, studies on human placental development are hampered by the lack of a self-renewing in vitro model that would recapitulate formation of trophoblast progenitors and differentiated subtypes, syncytiotrophoblast (STB) and invasive extravillous trophoblast (EVT), in a 3D orientation. Hence, we established long-term expanding organoid cultures from purified first-trimester cytotrophoblasts (CTBs)...
July 31, 2018: Stem Cell Reports
C Juvet, U Simeoni, C Yzydorczyk, B Siddeek, J-B Armengaud, K Nardou, P Juvet, M Benahmed, F Cachat, H Chehade
Intrauterine growth restriction (IUGR) has been identified as a risk factor for adult chronic kidney disease (CKD), including hypertension (HTN). Accelerated postnatal catch-up growth superimposed to IUGR has been shown to further increase the risk of CKD and HTN. Although the impact of excessive postnatal growth without previous IUGR is less clear, excessive postnatal overfeeding in experimental animals shows a strong impact on the risk of CKD and HTN in adulthood. On the other hand, food restriction in the postnatal period seems to have a protective effect on CKD programming...
August 6, 2018: Journal of Developmental Origins of Health and Disease
Bobby Brar, David Jackson, Manita Nat, Pooja Patil, Brian Iriye, Petar Planinic
OBJECTIVE: Daily opioid dependence for maternal pain management, methadone maintenance, or buprenorphine/naloxone therapy is an increasing trend in modern obstetrics. Opioids may produce depressive effects on fetal neurobehavioral status and thus on fetal heart rate patterns. Our primary objective was to describe the current methods utilized in antenatal monitoring of the daily opioid exposed fetus; and to describe interventions based upon monitoring which precipitated a recommendation for delivery...
August 5, 2018: Journal of Maternal-fetal & Neonatal Medicine
S Zullino, F Buzzella, T Simoncini
Nitric oxide (NO) is a key regulator of both maternal and fetal homeostasis during pregnancy, facilitating the maternal cardio-vascular changes, fetal development and growth and adaptation to extrauterine life. Dysfunction of the NO system during pregnancy is associated to placental and vascular-related diseases such as hypertensive disorders of pregnancy (HDP) and intrauterine growth restriction (IUGR). Emerging therapeutic strategies involving NO precursors, NO donors, natural derivatives or pharmacological modulators of the NO system seem hold promise for the treatment of such conditions of pregnancy...
August 1, 2018: Vascular Pharmacology
Chih-Chieh Yang, Pei-Ling Tang, Po-Yen Liu, Wei-Chun Huang, Ying-Yao Chen, Hsiao-Ping Wang, Jenn-Tzong Chang, Li-Te Lin
The utero-placental ischemia induced by pregnancy-induced hypertension (PIH) could lead to fetal hypoxia and proinflammatory cytokine release, which are associated with the development of neonatal necrotizing enterocolitis (NEC). However, a few studies have investigated the relationship between PIH and neonatal NEC and have produced controversial results. Therefore, we attempted to assess the relationship between PIH and the subsequent neonatal NEC risk and identify predictive risk factors.Patients with newly diagnosed PIH were recruited from the Taiwan National Health Insurance Research Database (NHIRD)...
August 2018: Medicine (Baltimore)
Giorgia Sebastiani, Cristina Borrás-Novell, Miguel Alsina Casanova, Mireia Pascual Tutusaus, Silvia Ferrero Martínez, María Dolores Gómez Roig, Oscar García-Algar
The consumption of alcohol and drugs of abuse among pregnant women has experienced a significant increase in the last decades. Suitable maternal nutritional status is crucial to maintain the optimal environment for fetal development but if consumption of alcohol or drugs of abuse disrupt the intake of nutrients, the potential teratogenic effects of these substances increase. Despite evidence of the importance of nutrition in addicted pregnant women, there is a lack of information on the effects of alcohol and drugs of abuse on maternal nutritional status; so, the focus of this review was to provide an overview on the nutritional status of addicted mothers and fetuses...
August 2, 2018: Nutrients
Liang Hu, Fei Han, Lin Chen, Xie Peng, Daiwen Chen, De Wu, Lianqiang Che, Keying Zhang
Background: Intrauterine growth-restricted (IUGR) neonates impair postnatal skeletal muscle growth. The aim of this study was to investigate whether high nutrient intake (HNI) during the suckling period could improve muscle growth and metabolic status of IUGR pigs. Methods: Twelve pairs of IUGR and normal birth weight (NBW) pigs (7 days old) were randomly assigned to adequate nutrient intake and HNI formula milk groups. Psoas major (PM) muscle sample was obtained after 21 days of rearing...
2018: Genes & Nutrition
Xiao-Xiao Gao, Xiao-He Li, Qi-Fan Zhang, Ming Zhu, Yi-Xuan Guo, Kai-Ping Deng, Guo-Min Zhang, Feng Wang
Nutrient deficiency in ruminants can lead to estrus cycle disorders, a decreased pregnancy rate, and reduce birth weight. l-arginine (L-Arg), an important amino acid, can improve uterine homeostasis in pregnant sheep and prevent intrauterine growth restriction (IUGR). However, most studies of L-Arg have been conducted on pregnant sheep and few have reported the effects of L-Arg on microvessel density (MVD) in the non-pregnant ovine endometrium. The processes of normal uterine cyclical development and implantation are dependent on a balanced of endometrial MVD...
July 19, 2018: Theriogenology
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