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Intrauterine restriction growth

Chih-Ping Chen, Shu-Yuan Chang, Liang-Kai Wang, Tung-Yao Chang, Schu-Rern Chern, Peih-Shan Wu, Shin-Wen Chen, Shih-Ting Lai, Tzu-Yun Chuang, Chien-Wen Yang, Dai-Dyi Town, Li-Feng Chen, Wayseen Wang
OBJECTIVE: We present prenatal diagnosis of a 15q11.2 (BP1-BP2) microdeletion encompassing TUBGCP5, CYFIP1, NIPA2 and NIPA1 in a fetus with ventriculomegaly, microcephaly and intrauterine growth restriction (IUGR) on prenatal ultrasound. CASE REPORT: A 30-year-old, gravida 3, para 2, woman was referred to the hospital for amniocentesis because of fetal ventriculomegaly on prenatal ultrasound. Her husband was 31 years old. The couple had two healthy daughters, and there was no family history of mental disorders and congenital malformations...
October 2018: Taiwanese Journal of Obstetrics & Gynecology
Wentao Yu, Wei Gao, Dan Rong, Zhixian Wu, Raouf A Khalil
Preeclampsia is a pregnancy-related disorder characterized by hypertension and often fetal intrauterine growth restriction, but the underlying mechanisms are unclear. Defective placentation and apoptosis of invasive cytotrophoblasts cause inadequate remodeling of spiral arteries, placental ischemia and reduced uterine perfusion pressure (RUPP). RUPP causes imbalance between the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin and the pro-angiogenic vascular endothelial growth factor and placental growth factor, and stimulates the release of proinflammatory cytokines, hypoxia-inducible factor, reactive oxygen species, and angiotensin AT1 receptor agonistic autoantibodies...
October 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Margie H Davenport, Victoria L Meah, Stephanie-May Ruchat, Gregory A Davies, Rachel J Skow, Nick Barrowman, Kristi B Adamo, Veronica J Poitras, Casey E Gray, Alejandra Jaramillo Garcia, Frances Sobierajski, Laurel Riske, Marina James, Amariah J Kathol, Megan Nuspl, Andree-Anne Marchand, Taniya S Nagpal, Linda G Slater, Ashley Weeks, Ruben Barakat, Michelle F Mottola
OBJECTIVE: We aimed to identify the relationship between maternal prenatal exercise and birth complications, and neonatal and childhood morphometric, metabolic and developmental outcomes. DESIGN: Systematic review with random-effects meta-analysis and meta-regression. DATA SOURCES: Online databases were searched up to 6 January 2017. STUDY ELIGIBILITY CRITERIA: Studies of all designs were eligible (except case studies and reviews) if published in English, Spanish or French, and contained information on the relevant population (pregnant women without contraindication to exercise), intervention (subjective/objective measures of frequency, intensity, duration, volume or type of exercise, alone ('exercise-only') or in combination with other intervention components (eg, dietary; 'exercise+cointervention')), comparator (no exercise or different frequency, intensity, duration, volume, type or trimester of exercise) and outcomes (preterm birth, gestational age at delivery, birth weight, low birth weight (<2500 g), high birth weight (>4000 g), small for gestational age, large for gestational age, intrauterine growth restriction, neonatal hypoglycaemia, metabolic acidosis (cord blood pH, base excess), hyperbilirubinaemia, Apgar scores, neonatal intensive care unit admittance, shoulder dystocia, brachial plexus injury, neonatal body composition (per cent body fat, body weight, body mass index (BMI), ponderal index), childhood obesity (per cent body fat, body weight, BMI) and developmental milestones (including cognitive, psychosocial, motor skills))...
November 2018: British Journal of Sports Medicine
Michelle F Mottola, Taniya S Nagpal, Roberta Bgeginski, Margie H Davenport, Veronica J Poitras, Casey E Gray, Gregory A Davies, Kristi B Adamo, Linda G Slater, Nick Barrowman, Ruben Barakat, Stephanie-May Ruchat
OBJECTIVE: Theoretical concerns regarding the supine position at rest due to the gravid uterus obstructing aorta and vena caval flow may impinge uterine blood flow (UBF) to the fetus and maternal venous return. DESIGN: Systematic review. DATA SOURCES: Online databases up to 11 December 2017. STUDY CRITERIA: Eligible population (pregnant without contraindication to exercise), intervention (frequency, intensity, duration, volume or type of supine exercise), comparator (no exercise or exercise in left lateral rest position, upright posture or other supine exercise), outcomes (potentially adverse effects on maternal blood pressure, cardiac output, heart rate, oxygen saturation, fetal movements, UBF, fetal heart rate (FHR) patterns; adverse events such as bradycardia, low birth weight, intrauterine growth restriction, perinatal mortality and other adverse events as documented by study authors), and study design (except case studies and reviews) published in English, Spanish, French or Portuguese...
October 18, 2018: British Journal of Sports Medicine
Kelly B Zafman, Chloe S Getrajdman, Melanie K Arnold, Joanne L Stone
OBJECTIVE:  To determine if patients with a history of low pregnancy-associated plasma protein A (PAPP-A) in an initial pregnancy are at higher risk for adverse obstetric outcomes in a subsequent pregnancy. STUDY DESIGN:  This was a retrospective cohort study in patients who underwent first trimester screening for PAPP-A in two consecutive pregnancies. Two groups were examined: patients who had low PAPP-A in the first pregnancy followed by normal PAPP-A in the second pregnancy and patients who had recurrent low PAPP-A...
October 18, 2018: American Journal of Perinatology
Yehudit Michelson, Yaniv Lustig, Shira Avivi, Eli Schwartz, Amos Danielli
Background: Zika virus has created global alarm as it has been associated with catastrophic fetal abnormalities, including microcephaly, spontaneous abortion, and intrauterine growth restriction. Current serological assays that detect antiviral antibodies suffer from low sensitivity and high cross-reactivity among different flaviviruses. Methods: Here, utilizing a novel Magnetic Modulation Biosensing (MMB) system and the Zika non-structural 1 (NS1) protein, we show highly sensitive and specific Zika serological assays...
October 18, 2018: Journal of Infectious Diseases
S Brun, P Pennamen, A Mattuizzi, F Coatleven, M L Vuillaume, D Lacombe, B Arveiler, J Toutain, C Rooryck
OBJECTIVE: The aim of this study is to evaluate the diagnostic utility of prenatal diagnosis using Chromosomal Microarray Analysis (CMA) for fetuses presenting with isolated or associated Intrauterine Growth Restriction (IUGR). METHOD: We retrospectively included all fetuses with IUGR referred for prenatal testing and studied by rapid fluorescence in situ hybridization (FISH), karyotype and CMA. RESULTS: Among the 162 IUGR fetuses (78 associated and 84 isolated IUGR) included, 15 had an abnormal FISH result: 10 associated and five isolated fetal IUGRs...
October 17, 2018: Prenatal Diagnosis
Sebastian Quezada, Margie Castillo-Melendez, David W Walker, Mary Tolcos
KEY POINTS: Normal folding of the cerebral cortex (gyrification) is fundamental for neurodevelopment. Some molecular mechanisms of gyrification during fetal development have been identified, but the impact of maternal health and the intrauterine environment has been largely overlooked. Recent evidence suggests that the intrauterine environment has a significant impact on the normal folding of the fetal cerebral cortex. This article reviews evidence for the effect of the most common intrauterine alterations on the normal development of the cortical folding in the fetus...
October 16, 2018: Journal of Physiology
M Patabendige, G Barnasuriya, I Mampitiya
Antiphospholipid syndrome (APS) is associated with vascular thrombosis and pregnancy complications. It causes recurrent miscarriage and it is associated with other adverse pregnancy outcomes such as preterm delivery, intrauterine growth restriction, preeclampsia, and HELLP syndrome. Obstetric morbidity is one of the major manifestations of APS with a wide variety of clinical manifestations. This case describes a case of a severe preeclampsia in a 16-year-old primigravida at 29 weeks resulting in a caesarean delivery and subsequent finding of an ulnar artery thrombosis in postpartum period...
2018: Case Reports in Obstetrics and Gynecology
Yun-Zhi Shi, Song Jin, Han Qin, Heng-Bo Jiang, Guo-Hua Song, Shu-Cun Qin
Dehydration is one of the intrauterine abnormalities that could lead to fetal growth retardation and to increase the risk of a variety of adult diseases later in life. This study were to determine the impact of hydrogen-rich water (HRW) supplementation on placental angiotensin II type 1 receptor and placental oxidative stress induced by water restriction. Pregnant Wistar rat were randomly assigned to one of the three groups ( n =12 per group). In control group, pure water and food were supplied ad libitum. Water restriction group and HRW group were respectively given pure water and HRW with free access to food, excepting only one hour was available for drinking from day 7 to day 17 of pregnancy...
July 2018: Medical Gas Research
Laura Woods, Vicente Perez-Garcia, Myriam Hemberger
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development. One of the most common complications during pregnancy is insufficient growth of the fetus, a problem termed intrauterine growth restriction (IUGR) that is most frequently rooted in a malfunctional placenta. Together with conventional gene targeting approaches, recent advances in screening mouse mutants for placental defects, combined with the ability to rapidly induce mutations in vitro and in vivo by CRISPR-Cas9 technology, has provided new insights into the contribution of the genome to normal placental development...
2018: Frontiers in Endocrinology
Jessica Sabbatine Chimini, Jose Sergio Possomato-Vieira, Maria Luiza Santos da Silva, Carlos A Dias-Junior
preeclampsia and hypertensive disorders of pregnancy are frequently associated with feto-placental growth restriction and that may be triggered by angiogenic imbalance and endothelial dysfunction. Impaired nitric oxide (NO) bioavailability seems to be involved in these pathophysiological changes observed in hypertensive pregnancy. Pravastatin has shown efficacy and to be safe during hypertension in pregnancy. However, NO involvement in pravastatin effects during maternal hypertension and feto-placental development is unclear...
October 14, 2018: Basic & Clinical Pharmacology & Toxicology
Karolina Rutkowska, Monika Stachowiak, Jolanta Oprzadek, Stefan Bauersachs, Krzysztof Flisikowski
Intrauterine growth restriction (IUGR) is a serious pregnancy complication caused by placental insufficiency. We previously reported that truncation of MIMT1 gene exons 3 and 4 (MIMT1Del ) causes IUGR in cattle. Here we investigated miRNA expression in the foetal and maternal placenta tissues of MIMT1Del/WT foetuses. Small RNA next generation sequencing and quantitative PCR revealed placental tissue-specific expression of the miR-4321, known to regulate many genes involved in early foetal development. This study also indicated that maternal and foetal components of the placenta respond differently to a deleterious conceptus mutation...
October 2018: Placenta
Stefan Dugalić, Milos Petronijevic, Aleksandar Stefanovic, Katarina Jeremic, Svetlana Vrzic Petronijevic, Ivan Soldatovic, Igor Pantic, Irena Djunic, Zoran Jokic, Filip Djokovic, Jelena Dotlic, Milica Zaric, Jovana Todorovic
One of the risk factors for vascular obstetric complications, such as intrauterine growth restriction (IUGR), is inherited thrombophilias. Nevertheless, routine screening for thrombophilias is not endorsed in pregnant women due to their low prevalence and conflicting results of published studies regarding the usefulness of screening in these patients. The cause of IUGR remains unknown in almost 1 quarter of cases. There are no published studies evaluating the association of inherited thrombophilias and IUGR in patients with IUGR of unknown origin...
October 2018: Medicine (Baltimore)
Maria Vollsæter, Thomas Halvorsen, Trond Markestad, Knut Øymar, Per Magne Ueland, Klaus Meyer, Øivind Midttun, Anne-Lise Bjørke-Monsen
BACKGROUND: Preterm birth and low birth weight are associated with reduced nephron numbers and increased risk of hypertension and kidney disease in later life. AIMS: We tested the hypothesis that extremely preterm birth and intrauterine growth restriction is associated with decreased renal function in mid childhood. METHODS: At 11 years of age the following measures were obtained in a regional cohort of children born extremely premature (EP, i...
2018: PloS One
Asako Kumagai, Atsuo Itakura, Daisuke Koya, Keizo Kanasaki
Although the global maternal mortality ratio has been consistently reduced over time, in 2015, there were still 303,000 maternal deaths throughout the world, of which 99% occurred in developing countries. Understanding pathophysiology of pregnancy complications contributes to the proper prenatal care for the reduction of prenatal, perinatal and neonatal mortality and morbidity ratio. In this review, we focus on AMP-activated protein kinase (AMPK) as a regulator of pregnancy complications. AMPK is a serine/threonine kinase that is conserved within eukaryotes...
October 9, 2018: International Journal of Molecular Sciences
Brian Akhaphong, Amber Lockridge, Seokwon Jo, Ramkumar Mohan, Jacob A Wilcox, Cameron R Wing, Jean F Regal, Emilyn U Alejandro
Maternal hypertension during pregnancy is a major risk factor for intrauterine growth restriction (IUGR), which increases susceptibility to cardiovascular and metabolic disease in adulthood through unclear mechanisms. The aim of this study was to characterize pancreatic beta cell area and function in the fetal rat offspring of reduced uterine perfusion pressure (RUPP) model of gestational hypertension. At embryonic day 19.5, RUPP dams exhibited lower body weight, elevated mean blood pressure, reduced litter size, and higher blood glucose compared to sham-operated controls...
October 10, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Zhen Luo, Wenli Luo, Shaohua Li, Sen Zhao, Takami Sho, Xue Xu, Jing Zhang, Weina Xu, Jianxiong Xu
Intrauterine growth restriction (IUGR) remains a significant obstacle in pig production; however, information regarding the relationship between reactive oxygen species (ROS)-induced placental dysfunction and IUGR is still unknown. This study aimed to explore the placental redox status, mitochondrial content, cellular progression, and mitogen-activated protein kinase (MAPK) pathways in IUGR. Placental tissues were collected from normal intrauterine gestation (NIUG) and IUGR fetuses at delivery. Compared with the NIUG, placental ROS production, lipid peroxidation, and DNA damage were increased in IUGR...
October 6, 2018: Reproductive Biology
Erkan Kalafat, Asma Khalil
PURPOSE OF REVIEW: Two-thirds of the pregnancies complicated by stillbirth demonstrate growth restriction. Identification of the foetus at risk of growth restriction is essential to reduce the risk of stillbirth. The aim of this review is to critically appraise the current evidence regarding clinical utility of cerebroplacental ratio (CPR) in antenatal surveillance. RECENT FINDINGS: The CPR has emerged as an assessment tool for foetuses at increased risk of growth disorders...
October 6, 2018: Current Opinion in Obstetrics & Gynecology
Andrea Busnelli, Debora Lattuada, Stefania Ferrari, Marco Reschini, Barbara Colciaghi, Edgardo Somigliana, Luigi Fedele, Enrico Ferrazzi
Inflammation and oxidative stress are intrinsically linked to early poor placentation, typical of pregnancies complicated by preeclampsia associated with intrauterine growth restriction (PE-IUGR). Low mitochondrial DNA copy number (mtDNAcn) in peripheral blood constitutes a good peripheral surrogate marker of inflammation and oxidative stress. On these basis, we explored a possible correlation between mtDNAcn in peripheral blood in the first trimester of pregnancy and the PE-IUGR onset. To shed light on this issue, we setup a nested case-control study from a prospective cohort of pregnant women undergoing first-trimester aneuploidies screening...
October 8, 2018: Reproductive Sciences
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