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Intrauterine restriction growth

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https://www.readbyqxmd.com/read/30551235/association-of-antenatal-depression-with-clinical-subtypes-of-preterm-birth
#1
Kartik K Venkatesh, Kelly K Ferguson, Nicole A Smith, David E Cantonwine, Thomas F McElrath
OBJECTIVE:  To estimate the association between antenatal depression and spontaneous preterm birth (SPTB) relative to medically indicated preterm birth (MPTB). STUDY DESIGN:  This was a secondary analysis of a nested case-control study of preterm birth (PTB). The exposure was a clinical diagnosis of antenatal depression. The outcome was PTB at <37 weeks classified as SPTB (spontaneous labor, preterm premature rupture of membranes, placental abruption, and cervical shortening); and MPTB (preeclampsia and intrauterine growth restriction)...
December 14, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/30550759/postnatal-management-of-growth-failure-in-children-born-small-for-gestational-age
#2
REVIEW
Adriane de Andre Cardoso-Demartini, Margaret C S Boguszewski, Cresio A D Alves
OBJECTIVES: To discuss the etiology and growth consequences of small size at birth and the indications, effects, and safety of biosynthetic growth hormone therapy in children born small for gestational age. SOURCE OF DATA: A comprehensive and non-systematic search was carried out in the PubMed, LILACS, and SciELO databases from 1980 to the present day, using the terms "small for gestational age," "intrauterine growth restriction," and "growth hormone"...
December 11, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/30547777/obstetric-and-perinatal-outcomes-of-singleton-pregnancies-conceived-via-assisted-reproductive-technology-complicated-by-gestational-diabetes-mellitus-a-prospective-cohort-study
#3
Azam Kouhkan, Mohammad E Khamseh, Reihaneh Pirjani, Ashraf Moini, Arezoo Arabipoor, Saman Maroufizadeh, Roya Hosseini, Hamid Reza Baradaran
BACKGROUND: Growing evidence indicates that the risk of obstetric and perinatal outcomes is higher in women with assisted reproductive technology (ART). However, there is little known about pregnancy related complications and co-morbidity in gestational diabetes mellitus (GDM) following singleton pregnancies achieved by ART in comparison with spontaneous conception (SC). METHODS: Two hundred sixty singleton pregnant women conceived by ART and 314 pregnant women conceived by spontaneous conception (SC) were participated in this prospective cohort study...
December 14, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/30543835/quantification-of-fetal-steroids-in-nails-of-neonates-to-quantify-prenatal-stress-and-growth-restriction
#4
Viola Schmelter, Lena Antonaci, Susanne Fröhlich, Diran Herebian, Pablo Verde, Martin Heil, Thomas Hoehn
This study assesses the impact of prenatal stress and intrauterine growth restriction (IUGR) on the dehydroepiandrosterone (DHEA) and dehydroepiandrosteronesulfate (DHEAS) concentrations in nails of newborns. Nail samples were gained from 56 newborn infants. The concentration of DHEA and DHEAS was measured by liquid chromatography/tandem mass spectrometry. Prenatal stress was assessed by the Prenatal Distress Questionnaire and by the Life Experience Survey. Prenatal stress was not associated with infant nail DHEA or DHEAS concentrations...
December 10, 2018: Biological Psychology
https://www.readbyqxmd.com/read/30541390/cytokine-changes-in-maternal-peripheral-blood-correlate-with-time-to-delivery-in-pregnancies-complicated-by-premature-prelabor-rupture-of-the-membranes
#5
Stefania Ronzoni, Valerie Steckle, Rohan D'Souza, Kellie E Murphy, Stephen Lye, Oksana Shynlova
Premature prelabor rupture of the membranes (PPROM) causes one-third of preterm births worldwide and is most likely caused by subclinical intrauterine infection and/or inflammation. We proposed that women with systemic inflammation at the time of PPROM would have shorter latency. Peripheral blood samples were collected from 20 singleton pregnant women with PPROM between 23 ± 1 and 33 ± 6 weeks. The first sample was drawn within 48 hours of admission, followed by weekly blood draws until delivery. Pregnancies complicated with acute chorioamnionitis, preeclampsia, intrauterine growth restriction, obesity, substance abuse, and chronic maternal disease were excluded...
December 12, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/30535296/a-potential-role-for-gsk3beta-in-glucose-driven-intrauterine-catch-up-growth-in-maternal-obesity
#6
Sarah Appel, Jon Grothe, Sarah Storck, Ruth Janoschek, Inga Bae-Gartz, Maria Wohlfarth, Marion Handwerk, Eva Hucklenbruch-Rother, Alexandra Gellhaus, Jörg Dötsch
Obesity and an unhealthy nutrition are on the rise and affect also women in childbearing age and hence, during pregnancy. Despite normal or even high birth weight the offspring suffers from long term metabolic risks. We hypothesized that fetal growth is disturbed during different intrauterine phases. Underlying molecular events remain elusive. Female mice were fed either a control diet (SD) or a high fat diet (HFD) after weaning until mating and during pregnancy. Pregnant mice were sacrificed at gestational time points G15...
December 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/30534809/placental-findings-in-pregnancies-complicated-with-iugr-histopathological-and-immunohistochemical-analysis
#7
Maria Violeta Novac, Mihaela Niculescu, Maria Magdalena Manolea, Anda Lorena Dijmărescu, Dominic Gabriel Iliescu, Marius Bogdan Novac, Luciana Teodora Rotaru, Manuela Florica Stoenescu, Maria Carmen Tabacu, Ştefania Tudorache, Cristina Jana Busuioc, Ioana Andreea Gheonea
OBJECTIVE: Placental lesions and placental ischemia are typical elements of intrauterine growth restriction (IUGR). The aim of this study is to analyze histological and immunohistochemical (IHC) changes in the placentas of IUGR fetuses. MATERIALS AND METHODS: In this prospective study, 126 placentas from small for gestational age (SGA) pregnancies (newborns with birth weight <10th percentile) that formed the study group and 31 placentas from pregnancies without SGA representing control group, were included...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/30534030/association-of-fatty-acid-ethyl-esters-in-meconium-of-neonates-with-growth-deficits-at-birth-a-prospective-single-centre-cohort-study
#8
Hyun-Seung Lee, Yeon Hee Kim, Ho-Seok Kwak, Jung-Yeol Han, Sun-Jin Jo, Hae Kook Lee
Background: In this prospective cohort study, we investigated the association between fatty acid ethyl esters (FAEEs) in meconium as biomarkers of prenatal ethanol exposure and growth deficits, as birth outcomes, that constitute several of the key cardinal features of fetal alcohol syndrome. Methods: A total of 157 meconium samples were collected from enrolled infants within 24 hours of birth, and nine FAEEs were quantified using liquid chromatography/tandem mass spectrometry...
December 10, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/30528429/aspirin-pre-treatment-modulates-ozone-induced-fetal-growth-restriction-and-alterations-in-uterine-blood-flow-in-rats
#9
Colette N Miller, Urmila P Kodavanti, Erica J Stewart, Mette Schaldweiler, Judy H Richards, Allen D Ledbetter, Leslie T Jarrell, Samantha J Snow, Andres Henriquez, Aimen K Farraj, Janice A Dye
Prenatal exposure to ozone has been linked to low birth weight in people and fetal growth restriction in rats. Clinical recommendations suggest use of low dose aspirin to lower risk of preeclampsia and intrauterine growth restriction in high-risk pregnancies, yet its utility in mitigating the postnatal effects of gestational ozone exposure is unknown. The present study investigated the possibility of low dose aspirin to mitigate the effects of ozone exposure during pregnancy. Exposure to ozone impaired uterine arterial flow and induced growth restriction in fetuses of both sexes...
December 5, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/30527121/pregnancy-induced-hypertension-and-outcomes-in-early-and-moderate-preterm-infants
#10
Cheng-Qiu Lu, Jie Lin, Lin Yuan, Jian-Guo Zhou, Kun Liang, Qing-Hua Zhong, Jin-Hua Huang, Li-Ping Xu, Hui Wu, Zhi Zheng, Li-Li Ping, Yi Sun, Zhan-Kui Li, Ling Liu, Qin Lyu, Chao Chen
OBJECTIVE: To identify the effect of pregnancy induced hypertension on neonatal outcomes in early and moderate preterm infants of gestational age less than 34 weeks. STUDY DESIGN: Prospectively collected data in 773 premature deliveries less than 34 weeks from 10 centers in China between July 2014 and July 2016 were analyzed in this cohort study. Univariate and Multivariate regression analyses were conducted to exam the effect of pregnancy induced hypertension on neonatal outcomes, including mortality to discharge, intrauterine growth restriction, severe brain injury, neonatal respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, early onset of sepsis and retinopathy of prematurity...
October 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/30524373/maternal-protein-restriction-induces-alterations-in-hepatic-unfolded-protein-response-related-molecules-in-adult-rat-offspring
#11
Xiaomei Liu, Jun Wang, Linlin Gao, Yisheng Jiao, Caixia Liu
Intrauterine growth restriction (IUGR) leads to the development of metabolic syndrome in adulthood. To explore the potential mechanisms of metabolic imprinting, we investigated the effect of malnutrition in utero on hepatic unfolded protein response (UPR)-related genes in IUGR offspring. An IUGR rat model was developed by feeding a low-protein diet to pregnant rats. The expression levels and activity of hepatic UPR genes were analysed by quantitative PCR (qPCR) arrays and western blotting. The hepatic UPR molecules heat-shock 70-kDa protein 4l ( Hspa4l ), mitogen-activated protein kinase 10 ( Mapk10 ), and endoplasmic reticulum to nucleus signalling 2 ( Ern2 ) were markedly downregulated in IUGR foetuses, but the expression of Mapk10 and Ern2 returned to normal levels at 3 weeks postnatal...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30517142/components-of-the-antepartum-intrapartum-and-postpartum-exposome-impact-on-distinct-short-term-adverse-neonatal-outcomes-of-premature-infants-a-prospective-cohort-study
#12
Unzila Ali Nayeri, Catalin S Buhimschi, Guomao Zhao, Irina A Buhimschi, Vineet Bhandari
We aimed to test the hypothesis that determinants of the perinatal clinical exposome related to the underlying etiology of premature birth (PTB) impact differently on select neonatal outcomes. We conducted a prospective longitudinal study of 377 singleton preterm neonates [gestational age (GA) at birth: 23-34 weeks] separated into three distinct contemporaneous newborn cohorts: i) spontaneous PTB in the setting of intra-amniotic infection/inflammation (yes-IAI, n = 116); ii) spontaneous PTB in the absence of IAI (no-IAI, n = 130), and iii) iatrogenic PTB for preeclampsia (iPTB-PE, n = 131)...
2018: PloS One
https://www.readbyqxmd.com/read/30513528/the-tubular-damage-markers-neutrophil-gelatinase-associated-lipocalin-and-kidney-injury-molecule-1-in-newborns-with-intrauterine-growth-restriction
#13
Monika Kamianowska, Marek Szczepański, Elżbieta Ewa Kulikowska, Barbara Bebko, Anna Wasilewska
BACKGROUND: Intrauterine growth restriction (IUGR) is a poorly understood complication of pregnancy. It may be associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance, and end-stage renal disease. OBJECTIVES: The aim of this study was to check whether IUGR affects the function of renal tubules, as assessed by the tubular damage markers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1)...
December 4, 2018: Neonatology
https://www.readbyqxmd.com/read/30513135/prenatal-and-postnatal-presentation-of-prmt7-related-syndrome-expanding-the-phenotypic-manifestations
#14
Roee Birnbaum, Naama Yosha-Orpaz, Miri Yanoov-Sharav, Dvora Kidron, Hila Gur, Keren Yosovich, Tally Lerman-Sagie, Gustavo Malinger, Dorit Lev
Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyze the transfer of methyl groups from S-adenosyl-l-methionine to nitrogen atoms on arginine residues. Arginine methylation is involved in multiple biological processes, such as signal transduction, mRNA splicing, transcriptional control, DNA repair, and protein translocation. Currently, 10 patients have been described with mutations in PRMT7. The shared findings include: hypotonia, intellectual disability, short stature, brachydactyly, and mild dysmorphic features...
December 4, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/30512127/maternal-perinatal-outcome-in-women-with-sickle-cell-disease-a-comparison-of-two-time-periods
#15
John N Chang, Everett F Magann, Sarah A Novotny, Chad E Cooley, C Heath Gauss, Marc R Parrish, John C Morrison
OBJECTIVE: To compare pregnancy outcomes in women with sickle cell disease from recent deliveries with a similar group delivered earlier. METHODS: During a 12-year period (2005-2016), data from pregnant women with hemoglobin SS or SC were collected from three university medical centers and compared with earlier studies (1979-2003) involving similar patients. The primary endpoints were maternal complications during pregnancy and newborn outcomes. RESULTS: There were 278 patients in the control group (1979-2003) compared with 150 patients in the study group (2005-2016)...
December 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/30508105/effects-of-dietary-methionine-restriction-on-postnatal-growth-insulin-sensitivity-and-glucose-metabolism-in-intrauterine-growth-retardation-pigs-at-49-and-105-days-of-age
#16
Zhixiong Ying, Xiaoke Ge, Hao Zhang, Weipeng Su, Yue Li, Le Zhou, Lili Zhang, Tian Wang
This study was conducted to investigate the effects of methionine restriction (MR) on growth performance, insulin sensitivity, and hepatic and muscle glucose metabolism in intrauterine growth retardation (IUGR) pigs at 49 and 105 days of age. At weaning (day 21), 30 female normal birth weight (NBW) piglets were fed control diets with adequate methionine (NBW-CON), whereas 60 female IUGR piglets were fed either the control diets (IUGR-CON) or MR diets which were 30% reduced in methionine (IUGR-MR) (n=6 replicates (pens) with 5 piglets/replicate)...
December 2, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/30503519/dna-polymerase-epsilon-deficiency-causes-image-syndrome-with-variable-immunodeficiency
#17
Clare V Logan, Jennie E Murray, David A Parry, Andrea Robertson, Roberto Bellelli, Žygimantė Tarnauskaitė, Rachel Challis, Louise Cleal, Valerie Borel, Adeline Fluteau, Javier Santoyo-Lopez, Tim Aitman, Inês Barroso, Donald Basel, Louise S Bicknell, Himanshu Goel, Hao Hu, Chad Huff, Michele Hutchison, Caroline Joyce, Rachel Knox, Amy E Lacroix, Sylvie Langlois, Shawn McCandless, Julie McCarrier, Kay A Metcalfe, Rose Morrissey, Nuala Murphy, Irène Netchine, Susan M O'Connell, Ann Haskins Olney, Nandina Paria, Jill A Rosenfeld, Mark Sherlock, Erin Syverson, Perrin C White, Carol Wise, Yao Yu, Margaret Zacharin, Indraneel Banerjee, Martin Reijns, Michael B Bober, Robert K Semple, Simon J Boulton, Jonathan J Rios, Andrew P Jackson
During genome replication, polymerase epsilon (Pol ε) acts as the major leading-strand DNA polymerase. Here we report the identification of biallelic mutations in POLE, encoding the Pol ε catalytic subunit POLE1, in 15 individuals from 12 families. Phenotypically, these individuals had clinical features closely resembling IMAGe syndrome (intrauterine growth restriction [IUGR], metaphyseal dysplasia, adrenal hypoplasia congenita, and genitourinary anomalies in males), a disorder previously associated with gain-of-function mutations in CDKN1C...
November 23, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/30502592/a-review-of-the-reproductive-consequences-of-consanguinity
#18
REVIEW
Olubunmi Oniya, Karen Neves, Badreldeen Ahmed, Justin C Konje
BACKGROUND: Consanguinity is the close union, sexual relationship or marriage between persons who have common biological ancestors usually up to about 2nd cousins. Contrary to general opinion consanguinity is quite common and is practiced worldwide. It is an important topic as while rates of consanguineous unions in certain society have decreased over time, rates have remained stable or increased in other societies with rates as high as 80.6% in some communities. Our aim was to conduct a review looking at general aspects of consanguinity and any published reproductive outcomes in literature...
November 1, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/30501879/progressive-uterine-artery-occlusion-in-the-guinea-pig-leads-to-defects-in-placental-structure-that-relate-to-fetal-growth
#19
Jorge Lopez-Tello, Maria Angeles Jimenez-Martinez, Emilio A Herrera, Bernardo J Krause, Amanda N Sferruzzi-Perri
Intrauterine growth restriction (IUGR) is a common obstetric complication with immediate and life-long consequences for offspring health. Yet the mechanisms underlying its aetiology require elucidation. Recent work in the guinea pig shows that progressive uterine artery occlusion induced IUGR and vascular dysfunction in pups. Here we explore the extent to which uterine artery occlusion influences fetal outcomes via impacts on placental morphology. Our study demonstrates that uterine artery occlusion severely compromised both the labyrinth exchange zone (increased fibrosis and reduced vascularisation, trophoblast volume, surface area and diffusing capacity) and interlobium zone (increased apoptosis), which likely contributed to the IUGR observed...
December 2018: Placenta
https://www.readbyqxmd.com/read/30498368/pena-shokeir-syndrome-current-management-strategies-and-palliative-care
#20
REVIEW
Sumaiya Adam, Melantha Coetzee, Engela Magdalena Honey
Pena-Shokeir syndrome (PSS) type 1, also known as fetal akinesia deformation sequence, is a rare genetic syndrome that almost always results in intrauterine or early neonatal death. It is characterized by markedly decreased fetal movements, intrauterine growth restriction, joint contractures, short umbilical cord, and features of pulmonary hypoplasia. Antenatal diagnosis can be difficult. Ultrasound features are varied and may overlap with those of Trisomy 18. The poor prognosis of PSS is due to pulmonary hypoplasia, which is an important feature that distinguishes PSS from arthrogryposis multiplex congenital without pulmonary hypoplasia, which has a better prognosis...
2018: Application of Clinical Genetics
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