Yi Liu, Jiani Yi, Pin Wu, Jun Zhang, Xufan Li, Jia Li, Liyuan Zhou, Yong Liu, Haiming Xu, Enguo Chen, Honghe Zhang, Mingyu Liang, Pengyuan Liu, Xiaoqing Pan, Yan Lu
DNA methylation, an epigenetic mechanism that alters gene expression without changing DNA sequence, is essential for organism development and key biological processes like genomic imprinting and X-chromosome inactivation. Despite tremendous efforts in DNA methylation research, accurate quantification of cytosine methylation remains a challenge. Here, a single-base methylation quantification approach is introduced by weighting methylation of consecutive CpG sites (Wemics) in genomic regions. Wemics quantification of DNA methylation better predicts its regulatory impact on gene transcription and identifies differentially methylated regions (DMRs) with more biological relevance...
March 28, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)