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Thymoma recurrence survival

Vittorio Aprile, Pietro Bertoglio, Stylianos Korasidis, Diana Bacchin, Olivia Fanucchi, Paolo Dini, Marcello Carlo Ambrogi, Marco Lucchi
BACKGROUND: Phrenic nerve infiltration has been described in up to 33% of advanced thymomas; en-bloc resection causes diaphragmatic loss of function, with detrimental effects on pulmonary function. We report the outcomes of selected patients operated on for invasive thymoma with a "nerve sparing" technique. METHODS: From 1990 to 2015 we used "nerve sparing" surgery with the intention to treat all patients with advanced stage thymomas without preoperative evidence of hemi-diaphragmatic palsy, but with macroscopical evidence of phrenic nerve involvement...
October 15, 2018: Annals of Thoracic Surgery
Yeon Joo Kim, Su Ssan Kim, Si Yeol Song, Seung-Il Park, Dong Kwan Kim, Yong-Hee Kim, Hyeong Ryul Kim, Eun Kyung Choi
INTRODUCTION: We evaluated the clinical outcome of patients with stage III to IV thymomas (Ts) or stage II to IV thymic carcinomas (TCs) treated with complete thymectomy and local radiation therapy (LRT, targeting the tumor bed and anterior mediastinal areas only) or elective nodal irradiation (ENI, targeting the entire mediastinal and supraclavicular regions). MATERIALS AND METHODS: Data from 47 patients diagnosed with Ts or TCs and treated with surgery and adjuvant RT from May 2002 to May 2015 were analyzed...
September 21, 2018: Clinical Lung Cancer
Giulio Maurizi, Camilla Poggi, Antonio D'Andrilli, Camilla Vanni, Anna Maria Ciccone, Mohsen Ibrahim, Claudio Andreetti, Simone Maria Tierno, Federico Venuta, Erino Angelo Rendina
BACKGROUND: Advanced stage thymic tumours infiltrating Superior Vena Cava(SVC), when radically resectable, can be surgically treated by SVC prosthetic replacement within a multimodality therapeutic approach. We hereby present our series of patients undergoing SVC resection and prosthetic reconstruction for stage-III/IV thymic malignancies. METHODS: Between 1989 and 2015, 27 patients with thymic tumours(21 thymoma, 6 thymic carcinoma) infiltrating SVC underwent radical resection with SVC prosthetic replacement by a bovine pericardial conduit in 12 cases, a polytetrafluoroethylene(PTFE) conduit in 13, a porcine pericardial conduit in 1 and saphenous vein conduit in 1...
October 11, 2018: Annals of Thoracic Surgery
Alfonso Fiorelli, Giovanni Natale, Chiara Freda, Mario Santini
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed is whether thymomectomy can be equivalent to thymectomy for non-myasthenic early-stage thymoma in terms of recurrence and survival. Ten papers were chosen to answer the question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers were tabulated. All studies included in this analysis are retrospective; most of them are small and from single-institution experiences, and only 3 used propensity-matched analysis to minimize the patients' selection bias...
September 4, 2018: Interactive Cardiovascular and Thoracic Surgery
Emanuele Voulaz, Giulia Veronesi, Maurizio Infante, Umberto Cariboni, Alberto Testori, Pierluigi Novellis, Edoardo Bottoni, Eliseo Passera, Emanuela Morenghi, Marco Alloisio
Background: Complete thymectomy is recommended for thymic malignancies to reduce local recurrence and the likelihood of the long-term development of myasthenia gravis (MG). Thymus-conserving surgery (thymomectomy) seems to yield similar results, but evidence is still limited. The objective of this study was to assess if the oncological outcome, in terms of overall survival (OS) and disease-free survival (DFS), are comparable between radical thymectomy vs. conservative thymomectomy patients, and to assess if the outcome of the video-assisted thoracoscopic surgery (VATS) approach was similar to open surgery approach...
July 2018: Journal of Thoracic Disease
Jian Gong, Shengxin Jin, Xujing Pan, Guiye Wang, Lifang Ye, Hongqun Tao, Huaikai Wen, Yu Liu, Qipeng Xie
BACKGROUND: Thymoma is the most common primary anterior mediastinal neoplasm with a high recurrence rate. Long noncoding RNAs (lncRNAs) have recently been indicated to be used as diagnostic and prognostic indicators for different cancers. The aim of this study was to identify new tumor-specific prognostic lncRNA markers that can improve the treatment and follow-up of patients with thymomas. METHODS: One hundred seventeen thymoma patients with clinical information and level 3 RNAseqv2 data were downloaded from The Cancer Genome Atlas...
July 1, 2018: Clinical Laboratory
Claire Merveilleux du Vignaux, Eric Dansin, Laurent Mhanna, Laurent Greillier, Eric Pichon, Mallorie Kerjouan, Christelle Clement-Duchene, Bertrand Mennecier, Virginie Westeel, Marie Robert, Xavier Quantin, Gérard Zalcman, Luc Thiberville, Hervé Lena, Thierry Molina, Fabien Calcagno, Pierre Fournel, Julien Mazieres, Benjamin Besse, Nicolas Girard
BACKGROUND: Thymic epithelial tumors (TET) are rare malignancies that may be aggressive and difficult to treat. In the advanced setting, systemic treatments may be delivered as primary therapy before surgery or definitive radiotherapy, as exclusive treatment when no focal treatment is feasible, or in the setting of recurrences. RYTHMIC is the nationwide network for TET in France. The objective of the study was to describe the modalities and analyze the efficacy of systemic treatments for patients with advanced TET included in the RYTHMIC prospective database hosted by the French Thoracic Cancer Intergroup (IFCT)...
August 20, 2018: Journal of Thoracic Oncology
Kazutoshi Hamanaka, Tsutomu Koyama, Shunichiro Matsuoka, Tetsu Takeda, Kentaro Miura, Kyoko Yamada, Akira Hyogotani, Tatsuichiro Seto, Kenji Okada, Ken-Ichi Ito
OBJECTIVE: The purpose of this study is to elucidate the outcomes after surgical resection of Masaoka stage III-IV thymic epithelial tumors. METHODS: We retrospectively reviewed patients with Masaoka stage III-IV thymic epithelial tumor who underwent surgical resection from January 1995 to January 2017. The clinicopathological features, surgical procedures, and postoperative outcomes were investigated. RESULTS: Thirteen patients with thymoma and 18 patients with thymic carcinoma were assessed...
August 21, 2018: General Thoracic and Cardiovascular Surgery
Olumide B Gbolahan, Ryan F Porter, John T Salter, Constantin Yiannoutsos, Matthew Burns, E Gabriella Chiorean, Patrick J Loehrer
BACKGROUND: Thymoma and thymic carcinoma are neoplastic diseases with reported chemosensitivity to a broad range of agents. However, due to the rarity of these diseases, few prospective trials have been conducted in patients with advanced thymic malignancies. We conducted a prospective phase II trial to evaluate the clinical activity of pemetrexed, a multi-targeted anti-folate agent, in previously treated patients with thymoma (THY) and thymic carcinoma (TC). PATIENTS AND METHODS: Twenty-seven previously treated patients (THY = 16, TC = 11) with advanced, unresectable disease were treated with pemetrexed 500 mg/m2 IV every three weeks for a maximum of 6 cycles or until undue toxicity or progressive disease...
August 16, 2018: Journal of Thoracic Oncology
Zhitao Gu, Chun Chen, Yun Wang, Yucheng Wei, Jianhua Fu, Peng Zhang, Yongyu Liu, Renquan Zhang, Keneng Chen, Zhentao Yu, Liewen Pang, Yangchun Liu, Yin Li, Yongtao Han, Hezhong Chen, Xinming Zhou, Youbin Cui, Lijie Tan, Jianyong Ding, Yi Shen, Yuan Liu, Wentao Fang
OBJECTIVES: Video-assisted thoracoscopic surgery (VATS) has been increasingly used in the management of thymic epithelial tumours. However, its oncological efficacy remains to be proved. The purpose of this study is to compare the oncological outcomes following thoracoscopic versus open surgery in the case-matched groups of patients with early-stage thymic tumours from the Chinese Alliance for Research in Thymomas (ChART) retrospective database. METHODS: Between 1994 and 2012, a total of 1087 patients who underwent surgery for UICC (Union for International Cancer Control) pathological Stage I tumours from the ChART retrospective database were recruited for this study...
July 16, 2018: European Journal of Cardio-thoracic Surgery
Hanyue Li, Jiantao Li, Jia Huang, Yunhai Yang, Qingquan Luo
Background: To report the first and largest series of robotic-assisted mediastinal surgeries performed in a single center by the same surgical team in mainland China. Methods: From May 2009 to June 2017, 167 patients (100 males, 67 females), with a mean age of 50.2 years (range, 12-78 years), underwent robotic surgery for the treatment of a mediastinal mass. Data regarding the operation time, docking time, blood loss, conversion rate, morbidity, mortality and survival follow-up were collected and analyzed...
May 2018: Journal of Thoracic Disease
Xuxia Shen, Yan Jin, Lei Shen, Yihua Sun, Haiquan Chen, Yuan Li
BACKGROUND: Multilocular thymic cysts (MTCs) associated with thymomas or thymic carcinomas (TCs) are rare and may be misdiagnosed as other benign cystic lesions. METHODS: We retrospectively analysed 18 cases of thymomas or TCs associated with MTCs, which were retrieved from 309 consecutive patients with thymomas or TCs in the Chinese population, emphasizing clinicopathologic characteristics, immunophenotypes and the prognostic impact. RESULTS: A total of 14 tumours were described as cystic or solid-cystic masses, and the other 4 tumours were described as solid masses...
June 26, 2018: Diagnostic Pathology
Bulent Koçer, Tevfik Kaplan, Nesimi Günal, Bilge Gönenli Koçer, Yucel Akkaş, Rasih Yazkan, Koray Dural, Sezer Kulaçoğlu, Serdar Han
Background The aim of this study was to evaluate the results of R0 resection of thymoma to identify prognostic factors for long-term outcomes. Methods Data of 62 patients (28 male, 34 female) with a mean age of 47.26 ± 14.42 years, who underwent R0 resection for thymoma and were followed-up between February 2004 and March 2016, were analyzed retrospectively. Results Eight patients had a video-assisted thoracoscopic thymectomy and 54 had a transsternal extended thymectomy. During a mean follow-up of 128...
July 2018: Asian Cardiovascular & Thoracic Annals
He J Zhu, Bradford S Hoppe, Stella Flampouri, Debbie Louis, John Pirris, R Charles Nichols, Randal H Henderson, Catherine E Mercado
Background: Radiotherapy for thymic malignancies is technically challenging due to their close proximity to the heart, lungs, esophagus, and breasts, raising concerns about significant acute and late toxicities from conventional photon radiotherapy. Proton therapy (PT) may reduce the radiation dose to these vital organs, leading to less toxicity. We reviewed the dosimetry and outcomes among patients treated with PT for thymic malignancies at our institution. Methods: From January 2008 to March 2017, six patients with de novo Masaoka stages II-III thymic malignancies were treated with PT on an IRB-approved outcomes tracking protocol...
April 2018: Translational Lung Cancer Research
Sureyya Sarıhan, Ahmet Sami Bayram, Cengiz Gebitekin, Omer Yerci, Deniz Sıgırlı
Aim: The aim of this study was to evaluate thymic epithelial tumors (TETs) for treatment outcomes and prognostic factors on survival. Background: TETs are very rare neoplasms and multidisciplinary approach is recommended according to prognostic factors. Materials and methods: Between 1995 and 2013, 31 patients were treated with median 5400 cGy (range: 1620-6596 cGy) radiotherapy (RT). Eleven patients received adjuvant or concurrent chemotherapy...
March 2018: Reports of Practical Oncology and Radiotherapy
Jian-Feng Li, Ben-Gang Hui, Xiao Li, Rong-Xin Xiao, Guan-Chao Jiang, Jun Liu, Jun Wang
Background: The use of video-assisted thoracic surgery (VATS) in the treatment of thymoma is becoming more and more common. The aim of this study was to evaluate safety and effectiveness of thoracoscopic treatment of thymoma and, more importantly, to report long-term follow-up results of a large single-center cohort. Methods: A retrospective review of a prospective database was performed. In total, 150 patients who underwent VATS resection for thymoma at Peking University People's Hospital from April 2001 to November 2014 were retrospectively reviewed...
January 2018: Journal of Thoracic Disease
Michael Ried, Hans-Stefan Hofmann, Hendrik Dienemann, Martin Eichhorn
INTRODUCTION: For several years, hyperthermic intrathoracic chemotherapy (HITHOC) has been performed in a few departments for thoracic surgery in a multimodality treatment regime in addition to surgical cytoreduction. Specific data about HITHOC in Germany are still lacking. METHODS: Survey in written form to all departments of thoracic surgery in Germany. The objective is the evaluation of HITHOC with respect to number, indications, technique, perioperative protection measure and complications...
June 2018: Zentralblatt Für Chirurgie
Xiujuan Gui, Xinhai Zhu, Liangjun Guo, Guoqiang Tan, Yan Liu, Yi Tan, Qiufang Chen, Yuwei Song, Shaoqiang Lin
RATIONALE: Thymomas are associated with numerous autoimmune disorders, such as myasthenia gravis (MG), pure red cell aplasia (PRCA), and systemic lupus erythematosus (SLE). However, graft-versus-host disease (GVHD)-like erythroderma is a relatively uncommon paraneoplastic disorder associated with thymomas and signifies a poor prognosis. PATIENT CONCERNS: A 35-year-old woman with medical history significant for stage IVa type AB thymoma presented with patchy erythema over face, trunk, and extremities that failed to respond to topical steroids...
December 2017: Medicine (Baltimore)
Paolo Andrea Zucali, Tommaso De Pas, Giovannella Palmieri, Adolfo Favaretto, Antonio Chella, Marcello Tiseo, Michele Caruso, Matteo Simonelli, Matteo Perrino, Fabio De Vincenzo, Francesca Toffalorio, Vincenzo Damiano, Giulia Pasello, Erika Garbella, Marco Ali, Fabio Conforti, Margaret Ottaviano, Angela Cioffi, Sabino De Placido, Laura Giordano, Monica Bertossi, Annarita Destro, Luca Di Tommaso, Armando Santoro
Purpose No effective salvage treatments are available for patients with advanced/recurrent thymoma (T) or thymic carcinoma (TC) who have progressed after platinum-based chemotherapy. This study evaluated the activity of everolimus in patients with advanced/recurrent T or TC previously treated with cisplatin-containing chemotherapy. Patients and Methods This was a single-arm, single-stage, open-label, multicenter, phase II trial. Patients received oral everolimus 10 mg/d until disease progression, unacceptable toxicity, or patient refusal...
February 1, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Erkan Kaba, Berker Ozkan, Suat Erus, Salih Duman, Berk Cimenoglu, Alper Toker
PURPOSE: To analyze the role of surgery in patients with Masaoka stage IVa thymoma treated with multimodality therapy. METHODS: Of 191 patients undergoing surgery for thymoma in our department between January 2002 and December 2015, 39 (20.4%) had Masaoka stage IVa. Histopathological tumor type, myasthenic status of the Osserman-Genkins score, Masaoka stage at the first surgery, neoadjuvant treatment, number and type of surgeries, and survival rates were recorded...
February 20, 2018: Annals of Thoracic and Cardiovascular Surgery
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