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Thymoma recurrence survival

Zhitao Gu, Chun Chen, Yun Wang, Yucheng Wei, Jianhua Fu, Peng Zhang, Yongyu Liu, Renquan Zhang, Keneng Chen, Zhentao Yu, Liewen Pang, Yangchun Liu, Yin Li, Yongtao Han, Hezhong Chen, Xinming Zhou, Youbin Cui, Lijie Tan, Jianyong Ding, Yi Shen, Yuan Liu, Wentao Fang
OBJECTIVES: Video-assisted thoracoscopic surgery (VATS) has been increasingly used in the management of thymic epithelial tumours. However, its oncological efficacy remains to be proved. The purpose of this study is to compare the oncological outcomes following thoracoscopic versus open surgery in the case-matched groups of patients with early-stage thymic tumours from the Chinese Alliance for Research in Thymomas (ChART) retrospective database. METHODS: Between 1994 and 2012, a total of 1087 patients who underwent surgery for UICC (Union for International Cancer Control) pathological Stage I tumours from the ChART retrospective database were recruited for this study...
July 16, 2018: European Journal of Cardio-thoracic Surgery
Hanyue Li, Jiantao Li, Jia Huang, Yunhai Yang, Qingquan Luo
Background: To report the first and largest series of robotic-assisted mediastinal surgeries performed in a single center by the same surgical team in mainland China. Methods: From May 2009 to June 2017, 167 patients (100 males, 67 females), with a mean age of 50.2 years (range, 12-78 years), underwent robotic surgery for the treatment of a mediastinal mass. Data regarding the operation time, docking time, blood loss, conversion rate, morbidity, mortality and survival follow-up were collected and analyzed...
May 2018: Journal of Thoracic Disease
Xuxia Shen, Yan Jin, Lei Shen, Yihua Sun, Haiquan Chen, Yuan Li
BACKGROUND: Multilocular thymic cysts (MTCs) associated with thymomas or thymic carcinomas (TCs) are rare and may be misdiagnosed as other benign cystic lesions. METHODS: We retrospectively analysed 18 cases of thymomas or TCs associated with MTCs, which were retrieved from 309 consecutive patients with thymomas or TCs in the Chinese population, emphasizing clinicopathologic characteristics, immunophenotypes and the prognostic impact. RESULTS: A total of 14 tumours were described as cystic or solid-cystic masses, and the other 4 tumours were described as solid masses...
June 26, 2018: Diagnostic Pathology
Bulent Koçer, Tevfik Kaplan, Nesimi Günal, Bilge Gönenli Koçer, Yucel Akkaş, Rasih Yazkan, Koray Dural, Sezer Kulaçoğlu, Serdar Han
Background The aim of this study was to evaluate the results of R0 resection of thymoma to identify prognostic factors for long-term outcomes. Methods Data of 62 patients (28 male, 34 female) with a mean age of 47.26 ± 14.42 years, who underwent R0 resection for thymoma and were followed-up between February 2004 and March 2016, were analyzed retrospectively. Results Eight patients had a video-assisted thoracoscopic thymectomy and 54 had a transsternal extended thymectomy. During a mean follow-up of 128...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
He J Zhu, Bradford S Hoppe, Stella Flampouri, Debbie Louis, John Pirris, R Charles Nichols, Randal H Henderson, Catherine E Mercado
Background: Radiotherapy for thymic malignancies is technically challenging due to their close proximity to the heart, lungs, esophagus, and breasts, raising concerns about significant acute and late toxicities from conventional photon radiotherapy. Proton therapy (PT) may reduce the radiation dose to these vital organs, leading to less toxicity. We reviewed the dosimetry and outcomes among patients treated with PT for thymic malignancies at our institution. Methods: From January 2008 to March 2017, six patients with de novo Masaoka stages II-III thymic malignancies were treated with PT on an IRB-approved outcomes tracking protocol...
April 2018: Translational Lung Cancer Research
Sureyya Sarıhan, Ahmet Sami Bayram, Cengiz Gebitekin, Omer Yerci, Deniz Sıgırlı
Aim: The aim of this study was to evaluate thymic epithelial tumors (TETs) for treatment outcomes and prognostic factors on survival. Background: TETs are very rare neoplasms and multidisciplinary approach is recommended according to prognostic factors. Materials and methods: Between 1995 and 2013, 31 patients were treated with median 5400 cGy (range: 1620-6596 cGy) radiotherapy (RT). Eleven patients received adjuvant or concurrent chemotherapy...
March 2018: Reports of Practical Oncology and Radiotherapy
Jian-Feng Li, Ben-Gang Hui, Xiao Li, Rong-Xin Xiao, Guan-Chao Jiang, Jun Liu, Jun Wang
Background: The use of video-assisted thoracic surgery (VATS) in the treatment of thymoma is becoming more and more common. The aim of this study was to evaluate safety and effectiveness of thoracoscopic treatment of thymoma and, more importantly, to report long-term follow-up results of a large single-center cohort. Methods: A retrospective review of a prospective database was performed. In total, 150 patients who underwent VATS resection for thymoma at Peking University People's Hospital from April 2001 to November 2014 were retrospectively reviewed...
January 2018: Journal of Thoracic Disease
Michael Ried, Hans-Stefan Hofmann, Hendrik Dienemann, Martin Eichhorn
INTRODUCTION: For several years, hyperthermic intrathoracic chemotherapy (HITHOC) has been performed in a few departments for thoracic surgery in a multimodality treatment regime in addition to surgical cytoreduction. Specific data about HITHOC in Germany are still lacking. METHODS: Survey in written form to all departments of thoracic surgery in Germany. The objective is the evaluation of HITHOC with respect to number, indications, technique, perioperative protection measure and complications...
June 2018: Zentralblatt Für Chirurgie
Xiujuan Gui, Xinhai Zhu, Liangjun Guo, Guoqiang Tan, Yan Liu, Yi Tan, Qiufang Chen, Yuwei Song, Shaoqiang Lin
RATIONALE: Thymomas are associated with numerous autoimmune disorders, such as myasthenia gravis (MG), pure red cell aplasia (PRCA), and systemic lupus erythematosus (SLE). However, graft-versus-host disease (GVHD)-like erythroderma is a relatively uncommon paraneoplastic disorder associated with thymomas and signifies a poor prognosis. PATIENT CONCERNS: A 35-year-old woman with medical history significant for stage IVa type AB thymoma presented with patchy erythema over face, trunk, and extremities that failed to respond to topical steroids...
December 2017: Medicine (Baltimore)
Paolo Andrea Zucali, Tommaso De Pas, Giovannella Palmieri, Adolfo Favaretto, Antonio Chella, Marcello Tiseo, Michele Caruso, Matteo Simonelli, Matteo Perrino, Fabio De Vincenzo, Francesca Toffalorio, Vincenzo Damiano, Giulia Pasello, Erika Garbella, Marco Ali, Fabio Conforti, Margaret Ottaviano, Angela Cioffi, Sabino De Placido, Laura Giordano, Monica Bertossi, Annarita Destro, Luca Di Tommaso, Armando Santoro
Purpose No effective salvage treatments are available for patients with advanced/recurrent thymoma (T) or thymic carcinoma (TC) who have progressed after platinum-based chemotherapy. This study evaluated the activity of everolimus in patients with advanced/recurrent T or TC previously treated with cisplatin-containing chemotherapy. Patients and Methods This was a single-arm, single-stage, open-label, multicenter, phase II trial. Patients received oral everolimus 10 mg/d until disease progression, unacceptable toxicity, or patient refusal...
February 1, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Erkan Kaba, Berker Ozkan, Suat Erus, Salih Duman, Berk Cimenoglu, Alper Toker
PURPOSE: To analyze the role of surgery in patients with Masaoka stage IVa thymoma treated with multimodality therapy. METHODS: Of 191 patients undergoing surgery for thymoma in our department between January 2002 and December 2015, 39 (20.4%) had Masaoka stage IVa. Histopathological tumor type, myasthenic status of the Osserman-Genkins score, Masaoka stage at the first surgery, neoadjuvant treatment, number and type of surgeries, and survival rates were recorded...
February 20, 2018: Annals of Thoracic and Cardiovascular Surgery
Michael Ried, Maria-Magdalena Eicher, Reiner Neu, Zsolt Sziklavari, Hans-Stefan Hofmann
BACKGROUND: The objective of this study is the evaluation of the Masaoka-Koga and the International Association for the Study of Lung Cancer (IASLC)/International Thymic Malignancy Interest Group (ITMIG) proposal for the new TNM-staging system on clinical implementation and prognosis of thymic malignancies. METHODS: A retrospective study of 76 patients who underwent surgery between January 2005 and December 2015 for thymoma. Kaplan-Meier survival analysis was used to determine overall and recurrence-free survival rates...
December 2, 2017: World Journal of Surgical Oncology
Sukhmani K Padda, Xiaopan Yao, Alberto Antonicelli, Jonathan W Riess, Yue Shang, Joseph B Shrager, Robert Korst, Frank Detterbeck, James Huang, Bryan M Burt, Heather A Wakelee, Sunil S Badve
INTRODUCTION: Thymic epithelial tumors (TETs) are associated with paraneoplastic/autoimmune (PN/AI) syndromes. Myasthenia gravis is the most common PN/AI syndrome associated with TETs. METHODS: The International Thymic Malignancy Interest Group retrospective database was examined to determine (1) baseline and treatment characteristics associated with PN/AI syndromes and (2) the prognostic role of PN/AI syndromes for patients with TETs. The competing risks model was used to estimate cumulative incidence of recurrence (CIR) and the Kaplan-Meier method was used to calculate overall survival (OS)...
March 2018: Journal of Thoracic Oncology
Giuseppe L Banna, Ankur Sheel, Varun Sheel, Andrea Bille, Tom Routledge, Shalini Fernando, Arjun Nair, Rohit Lal
AIM: The treatment of patients with recurrent or progressive thymic epithelial tumors remains uncertain due to limited data in this rare disease. MATERIALS & METHODS: A retrospective 10-year monoinstitutional analysis was conducted on 25 patients with first recurrence or disease progression following primary treatment. RESULTS: Twenty patients had thymoma, five thymic carcinomas. Ten patients (40%) received surgery, four (40%) following chemotherapy; 17 (68%) had chemotherapy, with a combination regimen in 16 of them (94%)...
November 2017: Future Oncology
Makoto Odaka, You Tsukamoto, Takamasa Shibasaki, Shohei Mori, Hisatoshi Asano, Makoto Yamashita, Toshiaki Morikawa
Thymoma remains the most common primary anterior mediastinal neoplasm. Surgical resection remains central to the treatment of thymoma, with thoracoscopic thymectomy (TT) being increasingly performed. This present review article aimed to summarize current studies comparing TT and open thymectomy (OT). Recently, most patients with Masaoka stage I-II thymoma have been receiving TT. This procedure is associated with a significantly shorter post-operative hospital stay, decreased intraoperative blood loss, and fewer complications compared with OT...
2017: Journal of Visualized Surgery
Masahiro Yanagiya, Jun-Ichi Nitadori, Kazuhiro Nagayama, Masaki Anraku, Masaaki Sato, Jun Nakajima
PURPOSE: The preoperative peripheral neutrophil-to-lymphocyte ratio (NLR) is associated with a poor prognosis for various cancers. We evaluated the prognostic role of the preoperative NLR in patients with thymoma. METHODS: We reviewed the medical records of 254 patients who underwent resection of thymic epithelial tumors at our institution. Patients were excluded if they had received steroid therapy, neoadjuvant therapy, or incomplete resection, or if they had thymic carcinoma or Good's syndrome, recurrence of thymoma, or missing data...
April 2018: Surgery Today
Jacqueline A Hill, Susan L Fubini, Richard P Hackett
OBJECTIVE To determine the anatomic location and clinical signs of thymoma in goats and long-term outcomes in a subset of goats treated by tumor excision. DESIGN Retrospective case series. ANIMALS 13 goats with a histologic diagnosis of thymoma at the Cornell University Hospital for Animals between 1990 and 2014. PROCEDURES Medical records of goats with thymoma were reviewed and data were evaluated regarding signalment, clinical signs, diagnostic imaging results, thymoma size, treatment, and outcome. Follow-up information was obtained via contact with the owners and review of medical records...
October 1, 2017: Journal of the American Veterinary Medical Association
Camille Mazza, Jordi Remon, Charles Honoré, Benjamin Besse
Thymomas are rare (1,5 cases/million) and typically occur in adults with a median age of 50 years old. Thymomas are indolent with a 10-year overall survival for resected stage II thymomas of 70%. Late relapses occur in 20% of the cases, and distant metastasis from thymoma is rare. Peritoneal recurrence of thymoma treated with surgery associated with hyperthermic intraperitoneal chemotherapy (HIPEC) has not been described in the literature. This report manages peritoneal recurrence of thymoma with HIPEC, suggesting that aggressive therapies may decrease the risk of recurrence...
September 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Qing Lin, Ye Zhang, Liuchun Yang
PURPOSE: We conducted this study to retrospectively analyze the clinical effects of surgical resection for patients with myasthenia gravis (MG) complicated with thymoma. METHODS: 162 patients with myasthenia gravis complicated with thymoma, that were admitted to our hospital and underwent surgical disease resection from Nov. 1993 to Nov. 2015, were selected for this study. Analyzed were the pathology (2004 WHO), Masaoka clinical stage, myasthenia gravis types (Osserman types), myasthenic crisis during the perioperative period, and the relationship between recurrence and survival rates during follow-up visits...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Yen-Chiang Tseng, Yen-Han Tseng, Hua-Lin Kao, Chih-Cheng Hsieh, Teh-Ying Chou, Yih-Gang Goan, Wen-Hu Hsu, Han-Shui Hsu
BACKGROUND AND OBJECTIVES: Thymoma has a variable long-term oncological outcome after surgical resection. Survival and tumor recurrence were analyzed to determine the predisposing factors for tumor recurrence. METHODS: A total of 235 patients who underwent surgery for thymoma or thymic carcinoma from December 1997 to March 2013 were analyzed using Masaoka staging system and World Health Organization (WHO) histological classification. Surgical intervention included extended thymothymectomy via median sternotomy and thymomectomy via thoracotomy/ video-assisted thoracoscopic surgery (VATS)...
2017: PloS One
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