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Thymoma recurrence survival

Zhu Mei, He Wang, Shengnan Ren, Juan Wei, Yanhong Gu
RATIONALE: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma...
November 2018: Medicine (Baltimore)
Aurélien Maureille, Tanguy Fenouil, Bastien Joubert, Géraldine Picard, Véronique Rogemond, Anne-Laurie Pinto, Laure Thomas, François Ducray, Isabelle Quadrio, Dimitri Psimaras, Giulia Berzero, Jean-Christophe Antoine, Virginie Desestret, Jérôme Honnorat
OBJECTIVE: To report the clinical features and long-term outcome of 22 newly diagnosed paraneoplastic patients with GABAB receptor antibodies (GABAB R-Abs). METHODS: Retrospective clinical study of CSF-confirmed cases of GABAB R-Abs encephalitis. RESULTS: We identified 22 patients (4 female) with GABAB R-Abs, with a median age of 64 years (range 55-85). All were paraneoplastic: 20 small-cell lung cancer, one malignant thymoma, and one uncharacterized lung mass...
November 20, 2018: Journal of Neurology
Piergiorgio Muriana, Angelo Carretta, Paola Ciriaco, Alessandro Bandiera, Giampiero Negri
BACKGROUND: The introduction of the new TNM staging system for thymic epithelial malignancies produced a significant increase in the proportion of patients with stage I disease. The identification of new prognostic factors could help to select patients for adjuvant therapies based on their risk of recurrence. Neutrophil-to-lymphocyte ratio (NLR) has recently gained popularity as reliable prognostic biomarker in many different solid tumors. The aim of this study is to assess the utility of NLR evaluation as a prognostic marker in patients with surgically-treated thymoma...
November 19, 2018: Journal of Cardiothoracic Surgery
Vittorio Aprile, Pietro Bertoglio, Stylianos Korasidis, Diana Bacchin, Olivia Fanucchi, Paolo Dini, Marcello Carlo Ambrogi, Marco Lucchi
BACKGROUND: Phrenic nerve infiltration has been described in up to 33% of advanced thymomas; en-bloc resection causes diaphragmatic loss of function, with detrimental effects on pulmonary function. We report the outcomes of selected patients operated on for invasive thymoma with a "nerve sparing" technique. METHODS: From 1990 to 2015 we used "nerve sparing" surgery with the intention to treat all patients with advanced stage thymomas without preoperative evidence of hemi-diaphragmatic palsy, but with macroscopical evidence of phrenic nerve involvement...
October 15, 2018: Annals of Thoracic Surgery
Yeon Joo Kim, Su Ssan Kim, Si Yeol Song, Seung-Il Park, Dong Kwan Kim, Yong-Hee Kim, Hyeong Ryul Kim, Eun Kyung Choi
INTRODUCTION: We evaluated the clinical outcome of patients with stage III to IV thymomas (Ts) or stage II to IV thymic carcinomas (TCs) treated with complete thymectomy and local radiation therapy (LRT, targeting the tumor bed and anterior mediastinal areas only) or elective nodal irradiation (ENI, targeting the entire mediastinal and supraclavicular regions). MATERIALS AND METHODS: Data from 47 patients diagnosed with Ts or TCs and treated with surgery and adjuvant RT from May 2002 to May 2015 were analyzed...
September 21, 2018: Clinical Lung Cancer
Giulio Maurizi, Camilla Poggi, Antonio D'Andrilli, Camilla Vanni, Anna Maria Ciccone, Mohsen Ibrahim, Claudio Andreetti, Simone Maria Tierno, Federico Venuta, Erino Angelo Rendina
BACKGROUND: Advanced stage thymic tumours infiltrating Superior Vena Cava(SVC), when radically resectable, can be surgically treated by SVC prosthetic replacement within a multimodality therapeutic approach. We hereby present our series of patients undergoing SVC resection and prosthetic reconstruction for stage-III/IV thymic malignancies. METHODS: Between 1989 and 2015, 27 patients with thymic tumours(21 thymoma, 6 thymic carcinoma) infiltrating SVC underwent radical resection with SVC prosthetic replacement by a bovine pericardial conduit in 12 cases, a polytetrafluoroethylene(PTFE) conduit in 13, a porcine pericardial conduit in 1 and saphenous vein conduit in 1...
October 11, 2018: Annals of Thoracic Surgery
Alfonso Fiorelli, Giovanni Natale, Chiara Freda, Mario Santini
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed is whether thymomectomy can be equivalent to thymectomy for non-myasthenic early-stage thymoma in terms of recurrence and survival. Ten papers were chosen to answer the question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers were tabulated. All studies included in this analysis are retrospective; most of them are small and from single-institution experiences, and only 3 used propensity-matched analysis to minimize the patients' selection bias...
September 4, 2018: Interactive Cardiovascular and Thoracic Surgery
Emanuele Voulaz, Giulia Veronesi, Maurizio Infante, Umberto Cariboni, Alberto Testori, Pierluigi Novellis, Edoardo Bottoni, Eliseo Passera, Emanuela Morenghi, Marco Alloisio
Background: Complete thymectomy is recommended for thymic malignancies to reduce local recurrence and the likelihood of the long-term development of myasthenia gravis (MG). Thymus-conserving surgery (thymomectomy) seems to yield similar results, but evidence is still limited. The objective of this study was to assess if the oncological outcome, in terms of overall survival (OS) and disease-free survival (DFS), are comparable between radical thymectomy vs. conservative thymomectomy patients, and to assess if the outcome of the video-assisted thoracoscopic surgery (VATS) approach was similar to open surgery approach...
July 2018: Journal of Thoracic Disease
Jian Gong, Shengxin Jin, Xujing Pan, Guiye Wang, Lifang Ye, Hongqun Tao, Huaikai Wen, Yu Liu, Qipeng Xie
BACKGROUND: Thymoma is the most common primary anterior mediastinal neoplasm with a high recurrence rate. Long noncoding RNAs (lncRNAs) have recently been indicated to be used as diagnostic and prognostic indicators for different cancers. The aim of this study was to identify new tumor-specific prognostic lncRNA markers that can improve the treatment and follow-up of patients with thymomas. METHODS: One hundred seventeen thymoma patients with clinical information and level 3 RNAseqv2 data were downloaded from The Cancer Genome Atlas...
July 1, 2018: Clinical Laboratory
Claire Merveilleux du Vignaux, Eric Dansin, Laurent Mhanna, Laurent Greillier, Eric Pichon, Mallorie Kerjouan, Christelle Clément-Duchêne, Bertrand Mennecier, Virginie Westeel, Marie Robert, Xavier Quantin, Gérard Zalcman, Luc Thiberville, Hervé Lena, Thierry Molina, Fabien Calcagno, Pierre Fournel, Julien Mazières, Benjamin Besse, Nicolas Girard
INTRODUCTION: Thymic epithelial tumors (TETs) are rare malignancies that may be aggressive and difficult to treat. In the advanced setting, systemic treatments may be delivered as primary therapy before surgery or definitive radiotherapy, as exclusive treatment when no focal treatment is feasible, or in the setting of recurrences. Réseau tumeurs THYMIques et Cancer (RYTHMIC) is the nationwide network for TETs in France. The objective of the study was to describe the modalities and analyze the efficacy of systemic treatments for patients with advanced TETs included in the RYTHMIC prospective database hosted by the French Thoracic Cancer Intergroup...
November 2018: Journal of Thoracic Oncology
Kazutoshi Hamanaka, Tsutomu Koyama, Shunichiro Matsuoka, Tetsu Takeda, Kentaro Miura, Kyoko Yamada, Akira Hyogotani, Tatsuichiro Seto, Kenji Okada, Ken-Ichi Ito
OBJECTIVE: The purpose of this study is to elucidate the outcomes after surgical resection of Masaoka stage III-IV thymic epithelial tumors. METHODS: We retrospectively reviewed patients with Masaoka stage III-IV thymic epithelial tumor who underwent surgical resection from January 1995 to January 2017. The clinicopathological features, surgical procedures, and postoperative outcomes were investigated. RESULTS: Thirteen patients with thymoma and 18 patients with thymic carcinoma were assessed...
December 2018: General Thoracic and Cardiovascular Surgery
Olumide B Gbolahan, Ryan F Porter, John T Salter, Constantin Yiannoutsos, Matthew Burns, E Gabriella Chiorean, Patrick J Loehrer
INTRODUCTION: Thymoma and thymic carcinoma (TC) are neoplastic diseases with reported chemosensitivity to a broad range of agents. However, because of the rarity of these diseases, few prospective trials have been conducted in patients with advanced thymic malignancies. We conducted a prospective phase II trial to evaluate the clinical activity of pemetrexed, a multitargeted antifolate agent, in previously treated patients with thymoma and TC. METHODS: A total of 27 previously treated patients (16 with thymoma and 11 with TC) with advanced, unresectable disease were treated with pemetrexed, 500 mg/m2 , intravenously every 3 weeks for a maximum of six cycles or until undue toxicity or progressive disease...
August 16, 2018: Journal of Thoracic Oncology
Zhitao Gu, Chun Chen, Yun Wang, Yucheng Wei, Jianhua Fu, Peng Zhang, Yongyu Liu, Renquan Zhang, Keneng Chen, Zhentao Yu, Liewen Pang, Yangchun Liu, Yin Li, Yongtao Han, Hezhong Chen, Xinming Zhou, Youbin Cui, Lijie Tan, Jianyong Ding, Yi Shen, Yuan Liu, Wentao Fang
OBJECTIVES: Video-assisted thoracoscopic surgery (VATS) has been increasingly used in the management of thymic epithelial tumours. However, its oncological efficacy remains to be proved. The purpose of this study is to compare the oncological outcomes following thoracoscopic versus open surgery in the case-matched groups of patients with early-stage thymic tumours from the Chinese Alliance for Research in Thymomas (ChART) retrospective database. METHODS: Between 1994 and 2012, a total of 1087 patients who underwent surgery for UICC (Union for International Cancer Control) pathological Stage I tumours from the ChART retrospective database were recruited for this study...
December 1, 2018: European Journal of Cardio-thoracic Surgery
Hanyue Li, Jiantao Li, Jia Huang, Yunhai Yang, Qingquan Luo
Background: To report the first and largest series of robotic-assisted mediastinal surgeries performed in a single center by the same surgical team in mainland China. Methods: From May 2009 to June 2017, 167 patients (100 males, 67 females), with a mean age of 50.2 years (range, 12-78 years), underwent robotic surgery for the treatment of a mediastinal mass. Data regarding the operation time, docking time, blood loss, conversion rate, morbidity, mortality and survival follow-up were collected and analyzed...
May 2018: Journal of Thoracic Disease
Xuxia Shen, Yan Jin, Lei Shen, Yihua Sun, Haiquan Chen, Yuan Li
BACKGROUND: Multilocular thymic cysts (MTCs) associated with thymomas or thymic carcinomas (TCs) are rare and may be misdiagnosed as other benign cystic lesions. METHODS: We retrospectively analysed 18 cases of thymomas or TCs associated with MTCs, which were retrieved from 309 consecutive patients with thymomas or TCs in the Chinese population, emphasizing clinicopathologic characteristics, immunophenotypes and the prognostic impact. RESULTS: A total of 14 tumours were described as cystic or solid-cystic masses, and the other 4 tumours were described as solid masses...
June 26, 2018: Diagnostic Pathology
Bulent Koçer, Tevfik Kaplan, Nesimi Günal, Bilge Gönenli Koçer, Yucel Akkaş, Rasih Yazkan, Koray Dural, Sezer Kulaçoğlu, Serdar Han
Background The aim of this study was to evaluate the results of R0 resection of thymoma to identify prognostic factors for long-term outcomes. Methods Data of 62 patients (28 male, 34 female) with a mean age of 47.26 ± 14.42 years, who underwent R0 resection for thymoma and were followed-up between February 2004 and March 2016, were analyzed retrospectively. Results Eight patients had a video-assisted thoracoscopic thymectomy and 54 had a transsternal extended thymectomy. During a mean follow-up of 128...
July 2018: Asian Cardiovascular & Thoracic Annals
He J Zhu, Bradford S Hoppe, Stella Flampouri, Debbie Louis, John Pirris, R Charles Nichols, Randal H Henderson, Catherine E Mercado
Background: Radiotherapy for thymic malignancies is technically challenging due to their close proximity to the heart, lungs, esophagus, and breasts, raising concerns about significant acute and late toxicities from conventional photon radiotherapy. Proton therapy (PT) may reduce the radiation dose to these vital organs, leading to less toxicity. We reviewed the dosimetry and outcomes among patients treated with PT for thymic malignancies at our institution. Methods: From January 2008 to March 2017, six patients with de novo Masaoka stages II-III thymic malignancies were treated with PT on an IRB-approved outcomes tracking protocol...
April 2018: Translational Lung Cancer Research
Sureyya Sarıhan, Ahmet Sami Bayram, Cengiz Gebitekin, Omer Yerci, Deniz Sıgırlı
Aim: The aim of this study was to evaluate thymic epithelial tumors (TETs) for treatment outcomes and prognostic factors on survival. Background: TETs are very rare neoplasms and multidisciplinary approach is recommended according to prognostic factors. Materials and methods: Between 1995 and 2013, 31 patients were treated with median 5400 cGy (range: 1620-6596 cGy) radiotherapy (RT). Eleven patients received adjuvant or concurrent chemotherapy...
March 2018: Reports of Practical Oncology and Radiotherapy
Jian-Feng Li, Ben-Gang Hui, Xiao Li, Rong-Xin Xiao, Guan-Chao Jiang, Jun Liu, Jun Wang
Background: The use of video-assisted thoracic surgery (VATS) in the treatment of thymoma is becoming more and more common. The aim of this study was to evaluate safety and effectiveness of thoracoscopic treatment of thymoma and, more importantly, to report long-term follow-up results of a large single-center cohort. Methods: A retrospective review of a prospective database was performed. In total, 150 patients who underwent VATS resection for thymoma at Peking University People's Hospital from April 2001 to November 2014 were retrospectively reviewed...
January 2018: Journal of Thoracic Disease
Michael Ried, Hans-Stefan Hofmann, Hendrik Dienemann, Martin Eichhorn
INTRODUCTION: For several years, hyperthermic intrathoracic chemotherapy (HITHOC) has been performed in a few departments for thoracic surgery in a multimodality treatment regime in addition to surgical cytoreduction. Specific data about HITHOC in Germany are still lacking. METHODS: Survey in written form to all departments of thoracic surgery in Germany. The objective is the evaluation of HITHOC with respect to number, indications, technique, perioperative protection measure and complications...
June 2018: Zentralblatt Für Chirurgie
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