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Sarcoma radiation

Varun Chowdhry, Saveli Goldberg, Thomas F DeLaney, Gregory M Cote, Ivan Chebib, Jason Kim, Santiago A Lozano-Calderón, Karen De Amorim Bernstein
Introduction: Myxoid liposarcoma (MLS) is a subtype of liposarcoma characterized morphologically by lipomatous differentiation with a myxoid stroma. The purpose of this study was to review clinical and pathological information for patients treated for MLS at our institution to better understand neoadjuvant and adjuvant therapy. Materials and Methods: An institutional database of sarcomas was queried for patients who were treated for MLS at our institution between 1992 and 2013...
2018: Sarcoma
Woo J Chi, Matthew M Hanasono, Theresa M Hofstede, Ruth A Aponte-Wesson
This clinical report describes the prosthodontic rehabilitation of a 22-year-old woman with a substantial treatment history of Ewing sarcoma of the left maxillary sinus. The patient was diagnosed with Ewing sarcoma at the age of 7 years and went through chemotherapy, radiation, surgical resection, and free-flap reconstruction, initially without prosthodontic rehabilitation. The patient aged 22 years was referred to the oral oncology clinic at The University of Texas MD Anderson Cancer Center for prosthodontic treatment...
November 30, 2018: Journal of Prosthetic Dentistry
Alexander L Lazarides, David L Kerr, Daniel P Nussbaum, R Timothy Kreulen, Jason A Somarelli, Dan G Blazer, Brian E Brigman, William C Eward
BACKGROUND: For many cancer types, survival is improved when patients receive management at treatment centers that encounter high numbers of patients annually. This correlation may be more important with less common malignancies such as sarcoma. Existing evidence, however, is limited and inconclusive as to whether facility volume may be associated with survival in soft tissue sarcoma. QUESTIONS/PURPOSES: The purpose of this study was to examine the association between facility volume and overall survival in patients with soft tissue sarcoma of the extremities...
April 23, 2018: Clinical Orthopaedics and related Research
Kazi Sazzad Manir, Abhishek Basu, Krishnangshu B Choudhury, Swapnendu Basu, Koushik Ghosh, Subir Gangopadhyay
Purpose: Soft tissue sarcoma (STS) is rare but aggressive neoplasm. Interstitial brachytherapy (ISBT) alone or combined with external beam radiotherapy (EBRT) as post-operative treatment improves loco-regional (LRC) and distant control. Material and methods: Out of twenty-nine non-metastatic STS (lower limb 64%) patients (median age 37 yrs), treated with surgery and post-operative ISBT during February 2011 - December 2016, 27 patients with > 6 months follow-up were analyzed...
October 2018: Journal of Contemporary Brachytherapy
Jan Patrick Huber, Julia Lang, Robert Thimme, Arthur Schmidt, Dominik Bettinger
CLINICAL PRESENTATION: A 51-year-old male patient presented to our emergency department with fever, aggravating coughing and orthopnoea. Clinical evaluation revealed pneumonia in the right lower lobe of the lung and due to typical radiological hallmarks, aspiration pneumonia was suspected. During the last months, he had suffered from several pneumonias. The patient's history showed that he suffered from alveolar soft tissue sarcoma which was first diagnosed in 1985. He was treated with right-sided hemihepatectomy for resection of liver metastases, further liver resections, 12 sessions of radiation therapy and seven transarterial chemoembolisation sessions...
November 21, 2018: Gut
Tharcisio Machado Coelho, Ricardo César Fogaroli, Antonio Cassio Assis Pellizzon, Douglas Guedes De Castro, Guilherme Rocha Melo Gondim, Maria Leticia Gobo Silva, Michael Jenwei Chen, Henderson Ramos
BACKGROUND: Patients with recurrent retroperitoneal and pelvic region tumors often require multimodal therapies. Intraoperative radiation therapy (IORT) can deliver high-dose radiation to tumor beds, even if first-line external beam radiation therapy (EBRT) was administered. We evaluated local control (LC) and survival in patients receiving IORT for recurrent tumors. METHODS: We retrospectively analyzed 41 patients with isolated pelvic or retroperitoneal recurrences of colorectal, gynecological, or retroperitoneal primary tumors...
November 20, 2018: Radiation Oncology
Linda M Youngwirth, Kyle Freischlag, Daniel P Nussbaum, Ehsan Benrashid, Dan G Blazer
INTRODUCTION: Primary sarcomas of the pancreas are rare, and the limited data regarding their presentation, oncologic profile, and survival have been derived from small case series. METHODS: The National Cancer Data Base (1998-2012) was queried for patients with primary sarcomas of the pancreas. Demographic and clinical features at the time of diagnosis were evaluated for all patients. Subjects who underwent surgical resection were identified, and logistic regression was used to identify variables associated with resection...
December 2018: Surgical Oncology
R L Haas, S van Beek, A Betgen, S Ali, C J Schneider, F Heres Diddens, A N Scholten, F Koetsveld, P Remeijer
INTRODUCTION: Many authors suggest that extremity soft tissue sarcomas (ESTS) do not change significantly in size during preoperative radiotherapy (RT). This conebeam CT study investigates the justification to deliver the entire course with one initial RT plan by observing anatomical changes during RT. METHODS: In 2015-2017, 99 ESTS patients were treated with either curative (n=80) or palliative intent (n=19) with a regimen of at least 6 fractions. CTV-to-PTV margin was 1cm...
November 14, 2018: Practical Radiation Oncology
Alessandro Ottaiano, Valerio Scotti, Chiara De Divitiis, Monica Capozzi, Carmen Romano, Antonino Cassata, Rossana Casaretti, Lucrezia Silvestro, Anna Nappi, Valeria Vicario, Alfonso De Stefano, Salvatore Tafuto, Massimiliano Berretta, Guglielmo Nasti, Antonio Avallone
Background: There are very few clinical or prognostic studies on the role of SRT (Stereotactic Radiation Therapy) in the continuum of care of metastatic colorectal cancer (mCRC) patients. Patients and methods: Patients affected by oligo-mCRC were treated with SRT before or after front-line standard treatments. SRT was delivered according to a risk-adapted protocol. Total body CT (Computed Tomography) scan was done before therapy and every three months thereafter...
October 16, 2018: Oncotarget
Giridhar M Shivaram, Anne Elizabeth Gill, Eric J Monroe, Kevin S H Koo, C Matthew Hawkins
BACKGROUND: Cone-beam CT is increasingly used in pediatric interventional radiology procedures. However, the feasibility or safety of using this mode of imaging guidance for percutaneous lung nodule biopsy in children has not been assessed. OBJECTIVE: To retrospectively evaluate safety and diagnostic accuracy of percutaneous lung nodule biopsy in people treated at a pediatric hospital using cone-beam CT with navigational overlay. MATERIALS AND METHODS: Thirty-six consecutive patients from two large tertiary-care children's hospitals with lung nodules of 48 mm or smaller underwent percutaneous lung nodule biopsy using cone-beam CT with navigational overlay...
November 8, 2018: Pediatric Radiology
Seong Eun Kim, Younggon Jung, Tae Hoon Oh, Uh Jin Kim, Seung-Ji Kang, Hee-Chang Jang, Kyung-Hwa Park, Kyung-Hwa Lee, Sook In Jung
BACKGROUND: The incidence of AIDS-defining cancers (ADCs) has decreased markedly in the era of highly active antiretroviral therapy (HAART). The occurrence of two ADCs is rare in people living with HIV or AIDS (PWHA) who are severely immunosuppressed or have incomplete virologic suppression. CASE PRESENTATION: We report a case of dual primary ADCs, especially NHL followed by KS, in a 70-year-old HIV-infected man who was on antiretroviral therapy and had successful virologic suppression...
November 8, 2018: BMC Cancer
Boya Abudu, Philip R Cohen
Sporotrichosis is a fungal infection known for its distinct pattern of infectious skin nodules. Several conditions can present with lesions that appear in a sporotrichoid pattern. An 82-year-old man that presented with three cutaneous nodules on his right leg in a sporotrichoid manner is described; biopsy of each lesion revealed a keratoacanthoma. In addition to keratoacanthomas, other neoplasms-albeit rarely-may be observed to occur in a sporotrichoid manner. These included squamous cell carcinoma (three patients), lymphoma (two patients), and one patient with each of the following: epithelioid sarcoma, Langerhans cell histiocytosis, melanoma, and peripheral nerve sheath tumor...
August 23, 2018: Curēus
Alexander Waselewski, Michael Joiner, Steven Raymond Miller
A 50-year-old woman previously diagnosed with acute myeloid leukaemia presented with a 3-month history of shortness of breath and a right-sided facial rash. A chest CT revealed an intracardiac mass in the right atrium extending into her superior and inferior vena cava. Surgery was performed to remove the mass and pathology was consistent with myeloid sarcoma. After surgery, adjuvant radiation therapy was directed to the residual disease. The patient eventually relapsed in other sites not including the right atrium and eventually succumbed to her disease...
November 1, 2018: BMJ Case Reports
Lorenzo Giannini, Fabiola Incandela, Marco Fiore, Alessandro Gronchi, Silvia Stacchiotti, Claudia Sangalli, Cesare Piazza
In the last decades, radiotherapy (RT) has become one of the cornerstones in the treatment of head and neck (HN) malignancies and has paralleled an increase in long-term patient survival. This lead to a concomitant increase in the incidence of radiation-induced sarcomas (RIS) of the irradiated field, with an annual rate up to 0.17%. The new techniques of irradiation do not seem to influence the risk of RIS of the HN (RISHN), which mainly develop within the middle-dose field. The median latency of RISHN after RT is 10-12 years and osteosarcoma is the most represented histotype, even though there is a high variability in time of occurrence and histological features observed...
2018: Frontiers in Oncology
Kripa Guram, Maria Nunez, John Einck, Loren K Mell, Ezra Cohen, P Dominick Sanders, Sayuri Miyauchi, Elizabeth Weihe, Razelle Kurzrock, Sarah Boles, Andrew B Sharabi
Background: Undifferentiated pleomorphic sarcoma (UPS) of the maxillary sinus is an extremely rare malignancy of the head and neck. Surgery is the mainstay of treatment for UPS; however, proximity to vital structures makes it challenging to achieve negative surgical margins. Adjuvant therapy including radiation therapy with or without chemotherapy is generally indicated. Despite advances in multimodality treatment, objective response rates to available therapies and prognosis of metastatic UPS remain dismal...
2018: Frontiers in Oncology
Helen Zieschang, Rainer Koch, Manfred P Wirth, Michael Froehner
PURPOSE: Leiomyosarcoma of the urinary bladder is exceedingly rare. Most clinicians come across only a few cases during their career, and information regarding treatment and outcome is scattered in the scientific literature. Interested clinicians and patients have to undertake troublesome search for treatment and outcome information. MATERIAL AND METHODS: We performed a systematic review of the literature using the PubMed and Web of Science databases and included all identified cases published in English language between 1970 and June 2018 into a meta-analysis...
November 1, 2018: Urologia Internationalis
Markus Albertsmeier, Falk Roeder, Martin K Angele
No abstract text is available yet for this article.
October 29, 2018: Annals of Surgical Oncology
Sarah Abaricia, Angela C Hirbe
Sarcomas are a heterogeneous group of rare malignancies that arise from mesenchymal cells and can occur anywhere in the body. Herein, the focus will be on one subtype of sarcoma that arises from adipocytic tissue, liposarcoma. Specifically, the review will focus on one type of liposarcoma, myxoid liposarcoma. Given the rarity of this tumor, it is imperative that these patients are treated at a sarcoma center, where a multidisciplinary approach incorporates all the modalities available including clinical trials...
October 25, 2018: Current Treatment Options in Oncology
Rohini Kadle, Catherine C Motosko, George A Zakhem, John T Stranix, Timothy Rapp, Pierre B Saadeh
PURPOSE:  Limb-sparing treatment of extremity soft tissue sarcomas requires wide resections and radiation therapy. The resulting complex composite defects necessitate reconstructions using either muscle or fasciocutaneous flaps, often in irradiated wound beds. METHODS:  A retrospective chart review was performed of all limb-sparing soft tissue sarcoma resections requiring immediate flap reconstruction from 2012 through 2016. RESULTS:  Forty-four patients with 51 flaps were identified: 25 fasciocutaneous and 26 muscle-based flaps...
October 24, 2018: Journal of Reconstructive Microsurgery
Simona Camero, Simona Ceccarelli, Francesca De Felice, Francesco Marampon, Olga Mannarino, Lucrezia Camicia, Enrica Vescarelli, Paola Pontecorvi, Barry Pizer, Rajeev Shukla, Amalia Schiavetti, Maria Giovanna Mollace, Antonio Pizzuti, Vincenzo Tombolini, Cinzia Marchese, Francesca Megiorni, Carlo Dominici
PURPOSE: PARP inhibitors (PARPi) are used in a wide range of human solid tumours but a limited evidence is reported in rhabdomyosarcoma (RMS), the most frequent childhood soft-tissue sarcoma. The cellular and molecular effects of Olaparib, a specific PARP1/2 inhibitor, and AZD2461, a newly synthesized PARP1/2/3 inhibitor, were assessed in alveolar and embryonal RMS cells both as single-agent and in combination with ionizing radiation (IR). METHODS: Cell viability was monitored by trypan blue exclusion dye assays...
October 24, 2018: Journal of Cancer Research and Clinical Oncology
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