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Sarcoma radiation

Marissa Guo, Kristen L Kolberg, Eleanor C Smith, Brandon W Smith, Jonah E Yousif, Jason L Kessler, Joseph R Linzey, Anda-Alexandra Calinescu, Gregory A Clines, Daniel E Spratt, Nicholas J Szerlip
BACKGROUND: Spinal metastases pose significant morbidity. For many histologies, the spine is a frequent site for bone metastases. This predilection is not fully understood and there are conflicting reports regarding the distribution within the vertebral body itself. Knowing this distribution will give clues as to the underlying biologic reason for this increased incidence in the spine and lead to a better understanding of tumor dispersion and growth. METHODS: We retrospectively examined MRIs of patients undergoing radiation to the spine from 2015 to 2017 for spinal metastases...
August 13, 2018: World Neurosurgery
Jitesh B Shewale, Kyle G Mitchell, David B Nelson, Anthony P Conley, David C Rice, Mara B Antonoff, Wayne L Hofstetter, Garrett L Walsh, Stephen G Swisher, Jack A Roth, Reza J Mehran, Ara A Vaporciyan, Annikka Weissferdt, Boris Sepesi
BACKGROUND AND OBJECTIVES: Chest wall sarcomas are rare and may demonstrate heterogeneous features. Surgery remains the mainstay of treatment with chemotherapy and radiotherapy used as adjuncts. Herein, we report outcomes of a large cohort of patients with primary chest wall sarcoma who underwent resection. METHODS: Records of 121 patients who underwent resection for primary chest wall sarcoma between 1998 and 2013 were reviewed. A thoracic pathologist reexamined all tumors and categorized them according to grade...
August 15, 2018: Journal of Surgical Oncology
Mohamed Y Elsaid, Ankita Shahi, Albert R Wang, Dana C Baiu, Chunrong Li, Lauryn R Werner, Sorabh Singhal, Lance T Hall, Jamey P Weichert, Eric A Armstrong, Bryan P Bednarz, Paul M Harari, Gopal Iyer, Mario Otto
Anti-tumor alkyl phospholipid analogs comprise a group of structurally related molecules with remarkable tumor selectivity. Some of these compounds have shown radiosensitizing capabilities. CLR127 is a novel, clinical-grade anti-tumor alkyl phospholipid ether analog, a subtype of synthetic alkyl phospholipids broadly targeting cancer cells with limited uptake in normal tissues. The purpose of this study was to investigate the effect of CLR127 to modulate radiation response across several adult and pediatric cancer types in vitro as well as in murine xenograft models of human prostate adenocarcinoma, neuroblastoma, Ewing sarcoma and rhabdomyosarcoma...
August 14, 2018: Molecular Cancer Therapeutics
Muhammad A Memon, Burcak Karaca, Rasha Aboelhassan, Mohsen Barsoum, Mustafa Erman, Mert Basaran, Alper Sevinc, Djedi Hanene, Cassandra Slader, Virginia Pilipovic, Kerboua Esma, Bouzid Kamel
PURPOSE: Soft tissue sarcomas (STS) are a heterogeneous group of rare mesenchymal neoplasms, accounting for < 1% of all newly diagnosed malignancies. These tumors can occur in almost any anatomic site though they most frequently occur in the extremities. The objective of the study was to describe the epidemiology, treatment paradigm, and real-world outcomes in the clinical management of metastatic STS (mSTS) in the Middle East and North Africa (MEA) region. METHODS: MOON was an observational, multicenter, retrospective patient chart review study which included 200 patients with mSTS in the final analysis...
August 13, 2018: Journal of Cancer Research and Clinical Oncology
Melody J Xu, Alison Liewen, Luca Valle, Adam C Olson, Nicola M Zetola, Surbhi Grover
Background: To synthesize published literature on the association between human immunodeficiency virus (HIV) infection and radiation therapy (RT)-related toxicities. Methods: Two electronic databases, MEDLINE and Embase, were searched to identify studies published before November 2016 comparing RT-related toxicities between HIV-infected and HIV-uninfected patients receiving RT or chemoradiation therapy (CRT) for cancer. A qualitative synthesis of included articles and organ-specific toxicities was then performed...
2018: Frontiers in Oncology
Sameer Tolay, Ranjit Nair, Alyson F McIntosh, Dennis M Sopka, Suresh G Nair
A substantial fraction of patients demonstrate resistance to immune checkpoint inhibitors, which limits their use. Use of radiation concurrently with checkpoint inhibitors has been shown to boost immune responsiveness, resulting in significant tumor regression in patients with metastatic melanoma. However, it is unknown whether radiation could play a role in reversing the inherent resistance to checkpoint inhibition in certain tumor types. Most trials testing this concurrent approach exclude such modestly responsive tumors and pursue checkpoint inhibition using anti-cytotoxic T-lymphocyte-associated protein 4 antibody (anti-CTLA-4, ipilimumab)...
August 13, 2018: Oncologist
Ziyad M Mohaidat, Abed-Allah A Saleh, Salah Al-Gharaibeh, Ibrahim R Yousef
BACKGROUND: Synovial sarcoma is a rare soft tissue sarcoma which most commonly affects the extremities of young adults. Axilla involvement by this sarcoma is very rare especially with involvement of the brachial plexus. This combination adds to the challenge in approaching such tumors which might significantly affect survival and function. CASE PRESENTATION: Herein, we present a 48-year-old female patient who presented with an isolated painless lump in her right axilla...
August 13, 2018: World Journal of Surgical Oncology
Eivind Rørvik, Lars Fredrik Fjæra, Tordis J Dahle, Jon Espen Dale, Grete May Engeseth, Camilla Hanqvuist Stokkevåg, Sara Thörnqvist, Kristian Smeland Ytre-Hauge
The relative biological effectiveness (RBE) of protons varies with multiple physical and biological factors. Phenomenological RBE models have been developed to include such factors in the estimation of a variable RBE, in contrast to the clinically applied constant RBE of 1.1. In this study, eleven published phenomenological RBE models and two plan-based models were explored and applied to simulated patient cases.&#13; Method and Materials: All models were analysed with respect to the distribution and range of linear energy transfer (LET) and reference radiation fractionation sensitivity ((α/β)&lt;sub&gt;x&lt;/sub&gt;) of their respective experimental databases...
August 13, 2018: Physics in Medicine and Biology
Landon S Wootton, Matthew J Nyflot, W Art Chaovalitwongse, Eric Ford
PURPOSE: To improve the detection of errors in intensity-modulated radiation therapy (IMRT) with a novel method that uses quantitative image features from radiomics to analyze gamma distributions generated during patient specific quality assurance (QA). METHODS AND MATERIALS: One hundred eighty-six IMRT beams from 23 patient treatments were delivered to a phantom and measured with electronic portal imaging device dosimetry. The treatments spanned a range of anatomic sites; half were head and neck treatments, and the other half were drawn from treatments for lung and rectal cancers, sarcoma, and glioblastoma...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Jin-Shan Zhang, Ge Wen, Yuan Liu, Zhao-Hong Wu, Gang-Dong Chen, Hao Wang, Tong-Chong Zhou
Extraskeletal osteosarcoma (ESOS) is a rare soft-tissue sarcoma that is treated with surgical resection, chemotherapy and radiotherapy; however, as it is now considered to be radiation resistance, it is associated with conflicting management principles and poor outcomes. A multimodality approach is currently used to treat ESOS, which entails the incorporation of multidrug chemotherapy and/or radiotherapy coupled with surgery to obtain the best outcome; however, there are many factors that influence the treatment effects and clinical outcomes of ESOS...
August 2018: Molecular and Clinical Oncology
Paola A Filomeno, Kyung-Phil Kim, Nara Yoon, Iran Rashedi, Victor Dayan, Rita A Kandel, Xing-Hua Wang, Tania C Felizardo, Elliot Berinstein, Salomeh Jelveh, Andrea Filomeno, Jeffrey A Medin, Peter C Ferguson, Armand Keating
BACKGROUND: Mesenchymal stromal cells (MSCs) promote wound healing, including after radiotherapy (RT) and surgery. The use of MSCs in regenerative medicine in the context of malignancy, such as to enhance wound healing post-RT/surgery in patients with soft tissue sarcomas (STSs), requires safety validation. The aim of this study was to determine the effects of human MSCs on STS growth in vitro and local recurrence and metastasis in vivo. METHODS: Human primary STS and HT-1080 fibrosarcoma lines were transduced to express luciferase/eGFP (enhanced green fluorescent protein)...
July 31, 2018: Cytotherapy
Monica Mangoni, Mariangela Sottili, Giulia Salvatore, Icro Meattini, Isacco Desideri, Daniela Greto, Mauro Loi, Carlotta Becherini, Pietro Garlatti, Camilla Delli Paoli, Luca Dominici, Chiara Gerini, Silvia Scoccianti, Pierluigi Bonomo, Angela Silvano, Giovanni Beltrami, Domenico Campanacci, Lorenzo Livi
Soft tissue sarcomas (STS) are aggressive tumors with a poor prognosis. Poly(ADP-ribose) polymerase (PARP)-1 inhibitors (PARPi) enhance the cytotoxic effects of radiation. In this study, we evaluated the effect of PARPi on survival and DNA damage of irradiated STS cells. For clonogenic assays, STS cell lines were irradiated with or without olaparib, iniparib or veliparib pretreatment. The effect of PARP inhibition on γ-H2AX and Rad51 foci formation, on PARP-1, phospho-ERK and cleaved caspase-3 protein expression and on cell cycle progression was evaluated on irradiated rhabdomyosarcoma cells pretreated with olaparib...
August 1, 2018: Radiation Research
Ahmed G Elsayed, Leesah Al-Qawasmi, Heather Katz, Yehuda Lebowicz
Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft tissue sarcoma with an indolent course and poor response to systemic treatment. We present a case of a 53-year-old male who presented with right gluteal extraskeletal myxoid chondrosarcoma. He was treated with wide local excision after receiving 50 Gray of neoadjuvant radiation therapy. Three years later he was found to have a left lower lobe lung nodule that was slowly increasing in size. He underwent a left lower lobectomy and the nodule was confirmed to be consistent with the patient's history of EMC...
May 30, 2018: Curēus
Yasushi Ishida, Miho Maeda, Souichi Adachi, Takeshi Rikiishi, Maho Sato, Hiroshi Kawaguchi, Atsushi Manabe, Mika Tokuyama, Hiroki Hori, Jun Okamura, Atsushi Ogawa, Hiroaki Goto, Ryoji Kobayashi, Shinji Yoshinaga, Junichiro Fujimoto, Tatsuo Kuroda
Background: Secondary cancer is the most life-threatening late effect of childhood cancer. We investigated the clinical features of secondary bone/soft tissue sarcoma among childhood cancer survivors (CCSs). Methods: We conducted a retrospective case-series study of 10 069 CCSs newly diagnosed with cancer between 1980 and 2009 across 15 Japanese hospitals. Twenty-one cases of pathologically diagnosed secondary bone/soft tissue sarcoma were selected, and the respective clinical courses were determined using additional questionnaires...
July 25, 2018: Japanese Journal of Clinical Oncology
Munetoshi Akazawa, Toshiaki Saito, Kazuya Ariyoshi, Masao Okadome, Ryohei Yokoyama, Kenichi Taguchi
A primitive neuroectodermal tumor (PENT) belongs to the category of a Ewing sarcoma. A PENT of the uterus is rare and has been known to be very aggressive by nature. Owing to the rarity of the tumor, there is no optimal treatment at present. In many cases, after hysterectomy, chemotherapy or radiation therapy has been performed. However, an effective chemotherapy regimen was unclear. In the soft tissue sarcoma area, the chemotherapy approach has recently greatly improved. Vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide (VDC-IE) therapy has improved the survival rate of patients with Ewing sarcoma/PENT...
July 26, 2018: Journal of Obstetrics and Gynaecology Research
Lawrence Williams, Lyubov Tmanova, Wojciech K Mydlarz, Brandi Page, Jeremy D Richmon, Harry Quon, Nicole C Schmitt
INTRODUCTION: Radiation-associated soft tissue sarcomas of the neck (RASN) constitute a rare and aggressive tumor type. METHODS: A retrospective chart review at the authors' institution revealed 3 patients with RASN. A systematic review of the literature was also conducted using MEDLINE, Ovid, the Cochrane Library, and Embase. RESULTS: Patients within the authors' institutional chart review presented from 6 to 26 years after neck radiation with neck masses...
July 26, 2018: Annals of Otology, Rhinology, and Laryngology
Gauthier Eloy, Caroline Daveau, Sarah Kreps, Pascaline Boudou-Rouquette, Philippe Anract, David Biau
PURPOSE: The use of adjuvant radiation in the treatment of soft-tissue sarcoma (STS) is equivocal in selected cases. Our objective was to compare the short-term outcomes in patients operated on for a local recurrence who had radiation for the primary tumour to those who were spared radiation. METHODS: This was a retrospective study of 103 patients treated for a local recurrence: 48 (47%) with previous radiation and 55 (53%) without. Our primary outcome criterion was to identify the differences in the local treatment provided...
July 25, 2018: International Orthopaedics
Michael J Nathenson, Anthony P Conley, Heather Lin, Nicole Fleming, Alexander Lazar, Wei-Lien Wang, Vinod Ravi
OBJECTIVE: This retrospective study examined the clinicopathologic features of adenosarcoma patients to determine potential prognostic factors and retrospectively evaluated overall survival (OS), disease-free survival (DFS), and local recurrence-free survival (LRFS) after primary treatment of adenosarcoma including surgery, radiation, and chemotherapy. METHODS: One hundred sixty-five patients with adenosarcoma were identified from the MD Anderson Cancer Center tumor registry between 1982 and 2014...
July 23, 2018: International Journal of Gynecological Cancer
Samuli H Salminen, Mika M Sampo, Tom O Böhling, Laura Tuomikoski, Maija Tarkkanen, Carl P Blomqvist
Radiation-associated sarcoma (RAS) is a rare complication of radiation therapy (RT) to breast cancer (BC). This study explored RAS after RT to BC in a nationwide population-based material. The Finnish Cancer Registry was queried for patients with BC treated during 1953-2014 who were later diagnosed with a secondary sarcoma in 1953-2014. Registry data, patient files, and sarcoma specimens were  analyzed to confirm diagnosis and location of RAS at or close to the RT target volume. A total of 132 512 patients were diagnosed with invasive BC during the study period...
July 25, 2018: Cancer Medicine
Tomonori Kanda, Yuichi Wakabayashi, Feibi Zeng, Yoshiko Ueno, Keitaro Sofue, Takaki Maeda, Munenobu Nogami, Takamichi Murakami
Radiation therapy is a useful treatment for tumors and vascular malformations of the central nervous system. Radiation therapy is associated with complications, including leukoencephalopathy, radiation necrosis, vasculopathy, and optic neuropathy. Secondary tumors are also often seen long after radiation therapy. Secondary tumors are often benign tumors, such as hemangiomas and meningiomas, but sometimes malignant gliomas and soft tissue sarcomas emerge. We review the imaging findings of complications that may occur after brain radiation therapy...
July 24, 2018: Japanese Journal of Radiology
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