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Sarcoma radiation

Min Wook Joo, Yong Koo Kang, Koichi Ogura, Shintaro Iwata, June Hyuk Kim, Won Ju Jeong, Xiaohui Niu, Pramod S Chinder, Han Soo Kim, Sung Wook Seo, Yang-Guk Chung
The oncologic risk of ionizing radiation is widely known. Sarcomas developing after radiotherapy have been reported, and they are a growing problem because rapid advancements in cancer management and screening have increased the number of long-term survivors. Although many patients have undergone radiation treatment in Asian countries, scarce reports on post-radiation sarcomas (PRSs) have been published. We investigated the feature and prognostic factors of PRSs in an Asian population. The Eastern Asian Musculoskeletal Oncology Group participated in this project...
2018: PloS One
Alain Joe Azzi, Sarah Zhou, Tyler Safran, Liqin Xu, Nayif Alnaif, Teanoosh Zadeh
INTRODUCTION: Radiation therapy (RT) is recommended for appropriately selected sarcoma patients to minimize the risk of local recurrence and to maximize outcomes of disease-free survival and function. The purpose of this study was to confirm the safety of vascularized tissue reconstruction in recently irradiated sarcoma defects. METHODS: A retrospective review of all patients treated by the senior author for sarcoma reconstruction from January 2005 to July 2017 was performed...
October 15, 2018: Annals of Plastic Surgery
Shihong Ren, Zhan Wang, Xin Huang, Lingling Sun, Jinxiang Shao, Zhaoming Ye
Background: Rhabdomyosarcoma (RMS) is a rare malignant soft tissue sarcoma with a poor outcome and unclear prognostic factors. The purpose of this study was to analyze the prognostic postoperative survival factors among patients with RMS of the limbs. Methods: Postoperative data on patients with RMS of the limbs from 1983 to 2013 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database of the US National Cancer Institute. Both overall survival (OS) and cancer-specific survival (CSS) were assessed using the Kaplan-Meier method (to obtain OS and CSS curves) and a Cox proportional hazards regression model...
2018: Cancer Management and Research
Wali Umer Shah, Syeda Dania Shujaat, Naseeb Ullah, Salman Mansoor
Synovial sarcoma is a soft-tissue sarcoma. Its involvement of the spine is extremely rare. We report a 40 year old male who presented with shoulder pain and progressive weakness in all four limbs for six months with a visible, slowly growing bulge in his upper back. On examination he had quadriparesis and diffuse sensory deficit. MRI of the cervical spine showed a large soft tissue mass, iso to hypointense, extending into the neural canal, compressing the cord. The mass had a few internal areas of contrast enhancement with extension into the right paraspinal regions involving the vertebral bodies...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Melike Elif Teker, Önder Teskin
BACKGROUND: Primary cardiac sarcoma is a rare and atypical clinical entity. We present a patient with long-term remission after primary cardiac sarcoma resection. CASE REPORT: A 42-year-old previously healthy female presented to the emergency department after an effort-induced 30-minute episode of chest pain and extreme shortness of breath. Physical examination upon admission was remarkable for a pulse of 99/minute; blood pressure was 101/73 mmHg. Transthoracic echocardiography showed a mass measuring 5...
September 25, 2018: Heart Surgery Forum
Michael J Nathenson, Constance M Barysauskas, Robert A Nathenson, William F Regine, Nader Hanna, Edward Sausville
BACKGROUND: Retroperitoneal soft tissue sarcomas (STS) include a number of histologies but are rare, with approximately 3000 cases in the USA per year. Retroperitoneal STS have a high incidence of local and distant recurrence. The purpose of this study was to review the University of Maryland Medical Center's (UMMC) treatment experience of retroperitoneal STS, where the patient population served represents a diverse socioeconomic and ethnic catchment. METHODS: IRB approval was obtained...
October 11, 2018: World Journal of Surgical Oncology
Sebastian Zschaeck, Peter Wust, Ingo Melcher, Jacek Nadobny, Daniel Rau, Jana Striefler, Stefan Pahl, Anne Flörcken, Annegret Kunitz, Pirus Ghadjar
PURPOSE: Localized adult high-grade soft tissue sarcomas (STS) usually require multimodality treatment including surgery, radiotherapy, chemotherapy and hyperthermia. If maximal preoperative tumor-shrinkage is envisaged, neoadjuvant chemotherapy + radiation (CRT) is often applied, however at the expense of relatively high toxicities and increased postoperative complication rates. This study aims to compare preoperative CRT with neoadjuvant chemotherapy + regional hyperthermia (HCT) regarding histopathological response, toxicity and outcome...
October 9, 2018: International Journal of Hyperthermia
A Italiano, Solène Bringer, J Y Blay, S Bonvalot, A Le Cesne, F Le Loarer, P Maingon
More than half of all cancer patients receive radiotherapy. With the increasing number of long-term cancer survivors, there is a growing concern about the risk of radiation induced second malignant neoplasm. Sarcomas represent the most frequent type of cancer than can be induced by radiation exposure. We report the largest series of radiation-induced sarcomas (RIS). We demonstrate that a majority of RIS can be cured, provided they underwent well-planned surgery.
October 5, 2018: International Journal of Radiation Oncology, Biology, Physics
Jonathan K Ramsey, James L Chen, Lynn Schoenfield, Raymond I Cho
Undifferentiated pleomorphic sarcoma is a malignancy of mesenchymal origin, which was previously known as malignant fibrous histiocytoma. It is known to occur on rare occasion as a primary orbital tumor, but no known cases of metastatic orbital involvement have been reported since 2002, when the reclassification of these tumors took place. The authors report a patient who presented with a metastasis to the left orbit 2 years after undergoing treatment of a high-grade undifferentiated pleomorphic sarcoma of the right thigh...
September 27, 2018: Ophthalmic Plastic and Reconstructive Surgery
Kyle D Klingbeil, Sameera S Vangara, Raymond M Fertig, Jason L Radick
A previously healthy, 47-year-old male presented to his primary care physician with the complaint of a nontender, palpable breast mass discovered coincidentally 1 month after being scratched in the same location by his pet cat. Family history revealed his father was diagnosed with a soft tissue sarcoma of the thigh, 6 months following a traumatic injury in the same location. Cat scratch disease was considered; however, Bartonella Henselae antibody testing was negative. Imaging studies revealed a subpectoral mass without rib involvement...
September 2018: Indian Journal of Surgical Oncology
Peter Y Yu, Eliza W Beal, Tasha M Hughes, Lorena P Suarez-Kelly, Rita D Shelby, Cecilia G Ethun, Thuy B Tran, George Poultsides, John Charlson, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Raphael E Pollock, Valerie Grignol, Kenneth Cardona, J Harrison Howard
BACKGROUND: The treatment benefit of perioperative chemotherapy (CTX) for truncal soft tissue sarcoma (STS) is not well established. This study evaluates the association of CTX with survival for patients with resected primary high-grade truncal STS. MATERIALS AND METHODS: Adult patients with high-grade truncal STS who had curative-intent resection from 2000 to 2016 at seven U.S. institutions were evaluated retrospectively. Patients were stratified by receipt of CTX...
November 2018: Journal of Surgical Research
Falk Roeder, Antonino de Paoli, Ladan Saleh-Ebrahimi, Ingo Alldinger, Giulio Bertola, Giovanni Boz, Federico Navarria, Miguel Cuervo, Matthias Uhl, Ana Alvarez, Markus Buechler, Burkhard Lehner, Juergen Debus, Felipe A Calvo, Robert Krempien
INTRODUCTION: We report a pooled analysis evaluating the combination of gross complete limb-sparing surgery, intraoperative electron radiation therapy (IOERT), and external beam radiation therapy (EBRT) in patients with extremity soft tissue sarcoma (STS). METHODS: Individual data of 259 patients (median follow-up 63 months) with extremity STS from three European expert centers were pooled. Median age was 55 years and median tumor size was 8 cm. Eighty percent of patients presented with primary disease, mainly located in the lower limb (81%)...
October 1, 2018: Annals of Surgical Oncology
Shyam Ravisankar, Yair Levy, Maya Shah
Acute myeloid leukemia (AML) can present with extramedullary involvement known as myeloid sarcoma (MS). We present the case of a young woman who was diagnosed with AML and MS in bilateral orbits, brain, omentum, and retroperitoneum. She was treated with induction chemotherapy. Low-dose radiation was given to the orbits due to visual symptoms which resulted in complete response. The use of radiation therapy in orbital MS has not been studied extensively, and low dose may be adequate to achieve complete remission (CR) in selected patients...
2018: Case Reports in Hematology
Thomas F DeLaney
No abstract text is available yet for this article.
September 27, 2018: Annals of Surgical Oncology
Nita L Seibel, Yueh-Yun Chi, Elizabeth J Perlman, Jing Tian, Junfeng Sun, James R Anderson, Michael L Ritchey, Patrick R Thomas, James Miser, John A Kalapurakal, Paul E Grundy, Daniel M Green
PURPOSE: To improve the event-free survival (EFS) and overall survival (OS) for patients with clear cell sarcoma of the kidney (CCSK) by incorporating cyclophosphamide and etoposide into treatment on National Wilms Tumor Study (NWTS)-5. PATIENTS AND METHODS: Patients less than 16 years of age with a centrally confirmed pathological diagnosis of CCSK were eligible for treatment on this prospective single-arm study conducted between August 1995 and June 2002. Staging consisted of CT scans of chest, abdomen, pelvis, bone scan, skeletal survey, and CT or MRI of the head...
September 25, 2018: Pediatric Blood & Cancer
Emily Z Keung, Alexander J Lazar, Keila E Torres, Wei-Lien Wang, Janice N Cormier, B Ashleigh Guadagnolo, Andrew J Bishop, Heather Lin, Kelly K Hunt, Justin Bird, Valerae O Lewis, Shreyaskumar R Patel, Jennifer A Wargo, Neeta Somaiah, Christina L Roland
BACKGROUND: Soft tissue sarcomas are a heterogeneous and rare group of solid tumors of mesenchymal origin that can arise anywhere in the body. Although surgical resection is the mainstay of treatment for patients with localized disease, disease recurrence is common and 5-year overall survival is poor (~ 65%). Both radiation therapy and conventional chemotherapy are used to reduce local and distant recurrence. However, the utility of radiation therapy is often limited by disease location (in the case of retroperitoneal sarcomas, for instance) while systemic therapy with conventional lines of chemotherapy offer limited efficacy and are often poorly tolerated and associated with significant toxicity...
September 24, 2018: BMC Cancer
Sinziana Dumitra, Alessandro Gronchi
Retroperitoneal sarcoma (RPS) is a rare tumor whose diagnosis and management can be challenging and for which management requires a multidisciplinary team in a specialized center. An important part of the diagnosis-identification of the histologic subtype-depends on pathology; identifying the histologic subtype is important because this can affect prognosis and treatment options. Complete surgical resection with negative margins remains the cornerstone of treatment of nonmetastatic RPS and is the only chance for cure...
September 15, 2018: Oncology (Williston Park, NY)
Richard J Cassidy, Jeffrey M Switchenko, Melinda L Yushak, Nicholas Madden, Mohammad K Khan, David K Monson, Jonathan J Beitler, Jerome C Landry, Karen D Godette, Theresa W Gillespie, Kirtesh R Patel
BACKGROUND: Scalp angiosarcomas (SA) are rare, representing <1% of soft tissue sarcomas. The optimal management of these tumors is unknown, with management based on small case series. We sought to assess the impact of different therapies on overall survival (OS), the practice patterns nationally, and identify factors associated with OS for non-metastatic scalp angiosarcomas. METHODS: A prospectively maintained database was used to identify non-metastatic scalp angiosarcomas who received some form of definitive therapy...
September 13, 2018: Surgical Oncology
Vaia Florou, Antonio G Nascimento, Ashish Gulia, Gilberto de Lima Lopes
Sarcomas, rare and heterogenous malignancies that comprise less than 1% of all cancers, have poor outcomes in the metastatic and refractory setting. Their management requires a multidisciplinary approach that consists of medical and surgical oncologists, radiation oncologists, and pathologists as well as ancillary support. In addition to systemic treatments, most patients will require surgical resection and radiation therapy, which mandates the use of the latest technologies and specialized expertise. Management guidelines have been developed in high-income countries, but their applicability in low-income countries, where resources may be limited, remains a challenge...
May 23, 2018: American Society of Clinical Oncology Educational Book
Juneko E Grilley-Olson, Nicholas P Webber, David S Demos, Jared D Christensen, David G Kirsch
Soft tissue sarcomas (STS) encompass a group of rare but heterogeneous diseases. Nevertheless, many patients, particularly those with oligometastatic disease can benefit from thoughtful multimodality evaluation and treatment regardless of the STS subtype. Here, we review surgical, interventional radiology, radiation, and chemotherapy approaches to maximize disease palliation and improve survival, including occasionally long-term disease-free survival. Surgical resection can include lung or other visceral, soft tissue and bone metastases with a goal of rendering the patient disease free...
May 23, 2018: American Society of Clinical Oncology Educational Book
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