keyword
https://read.qxmd.com/read/38531939/ultra-low-dose-computed-tomography-and-chest-x-ray-in-follow-up-of-high-grade-soft-tissue-sarcoma-a-prospective-comparative-study
#1
JOURNAL ARTICLE
Samuli Salminen, Sari Jäämaa, Riikka Nevala, Markus J Sormaala, Mika Koivikko, Erkki Tukiainen, Jussi Repo, Carl Blomqvist, Mika Sampo
Ultra-low-dose computed tomography (ULD-CT) may combine the high sensitivity of conventional computed tomography (CT) in detecting sarcoma pulmonary metastasis, with a radiation dose in the same magnitude as chest X-ray (CXR). Fifty patients with non-metastatic high-grade soft tissue sarcoma treated with curative intention were recruited. Their follow-up involved both CXR and ULD-CT to evaluate their different sensitivity. Suspected findings were confirmed by conventional CT if necessary. Patients with isolated pulmonary metastases were treated with surgery or stereotactic body radiation therapy (SBRT) with curative intent if possible...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38524062/an-unexpected-late-recurrence-of-breast-irradiation-induced-angiosarcoma-following-autologous-microvascular-breast-reconstruction
#2
Mohammed Herieka, Kavit Amin, Damir Kosutic
The authors present the case of a 68-year-old female who developed recurrent angiosarcoma, a rare but recognized complication after breast irradiation therapy in the treatment of breast cancer. Microvascular breast reconstruction was performed after the completion of 10 years of disease-free clinical surveillance. Abdominal tissue was harvested and transferred onto the chest wall with restoration of its blood supply using microsurgical techniques to recreate the breast. Unexpectedly, local recurrence of irradiation-induced angiosarcoma was confirmed in the reconstructed breast 12 years later, a unique finding, given the long latent period and recruitment of tissues from a distant site...
February 2024: Curēus
https://read.qxmd.com/read/38521165/neutrophil-to-lymphocyte-ratio-for-the-prediction-of-soft-tissue-sarcomas-response-to-pre-operative-radiation-therapy
#3
JOURNAL ARTICLE
Constanza Martinez, Rie Asso, Neelabh Rastogi, Carolyn Freeman, Fabio Cury
PURPOSE/OBJECTIVE: This study aims to assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in soft tissue sarcomas (STS) treated with pre-operative hypofractionated radiotherapy (HFRT). MATERIALS/METHODS: This retrospective analysis included patients treated with pre-operative HFRT of 30 Gy in 5 fractions between 2016 and 2023. Clinical, demographic, and complete blood count (CBC) data were collected. NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count...
March 21, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38520048/intraoperative-radiation-therapy-for-pediatric-sarcomas-and-other-solid-tumors
#4
JOURNAL ARTICLE
Brianna Conte, Dana L Casey, Kathryn R Tringale, Michael P LaQuaglia, J Ted Gerstle, Leonard Wexler, Michael V Ortiz, Suzanne L Wolden
PURPOSE: To evaluate local failure (LF) and toxicity after intraoperative radiation therapy (IORT) in pediatric solid tumors (ST). METHODS: A single-institution retrospective study of 96 pediatric patients (108 applications) with ST treated from 1995 to 2022 with IORT. LF was calculated via cumulative incidence function and overall survival (OS) by Kaplan-Meier method, both from the day of surgery. RESULTS: Median age at time of IORT was 8 years (range: 0...
March 22, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38519388/female-fertility-cryopreservation-outcomes-in-childhood-cancer-a-systematic-review
#5
REVIEW
Srinithya R Gillipelli, Luca Pio, Paul D Losty, Abdelhafeez H Abdelhafeez
BACKGROUND AND AIMS: As survival rates in childhood cancer progress significantly, health outcomes in adulthood are pivotal to quality of life (QoL). Female patients undergoing chemotherapy and radiation for childhood cancer may experience adverse effects such as gonadotoxicity-related ovarian insufficiency. Ovarian tissue cryopreservation (OTC) is well studied in adults, but has only recently started to be explored in an effort to preserve fertility in young patients with childhood cancer...
March 1, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38515338/risk-of-thoracic-soft-tissue-sarcoma-after-breast-cancer-radiotherapy-a-population-based-cohort-study-in-osaka-japan
#6
JOURNAL ARTICLE
Toshiki Ikawa, Yoshihiro Kuwabara, Kayo Nakata, Naoyuki Kanayama, Masahiro Morimoto, Isao Miyashiro, Koji Konishi
Postoperative radiotherapy for breast cancer reportedly increases the risk of thoracic soft tissue sarcomas, particularly angiosarcomas; however, the risk in the Japanese population remains unknown. Therefore, this study aimed to investigate the incidence of thoracic soft tissue sarcoma among patients with breast cancer in Japan and determine its association with radiotherapy. This retrospective cohort study used data from the population-based cancer registry of the Osaka Prefecture. The inclusion criteria were female sex, age 20-84 years, diagnosis of breast cancer between 1990 and 2010, no supraclavicular lymph node or distant metastasis, underwent surgery and survived for at least 1 year...
March 21, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38513152/intercalary-resection-of-the-tibia-for-primary-bone-tumors-are-vascularized-fibula-autografts-with-or-without-allografts-a-durable-reconstruction
#7
JOURNAL ARTICLE
Domenico Andrea Campanacci, Roberto Scanferla, Mariagrazia Marsico, Federico Scolari, Guido Scoccianti, Giovanni Beltrami, Luca Delcroix, Marco Innocenti, Rodolfo Capanna
BACKGROUND: Reconstruction with vascularized fibula grafts (VFG) after intercalary resection of sarcoma may offer longevity by providing early graft-host union and fracture healing. The ability of the fibula to hypertrophy under mechanical stress, as well as vascularized bone in the area, may also be advantageous, given that soft tissues may be compromised because of resection, chemotherapy, or radiation therapy. VFG with a massive allograft combines the primary mechanical stability of the graft with the biological potential of the vascularized fibula; however, complications and the durability of this combined reconstruction are not well described...
March 21, 2024: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/38508788/radiotherapy-combined-with-intralesional-immunostimulatory-agents-for-soft-tissue-sarcomas
#8
REVIEW
Chang Su, Soo Kyoung Kim, Charles X Wang, David G Kirsch, Arta M Monjazeb
Immunotherapy has shifted the treatment paradigm for many types of cancer. Unfortunately, the most commonly used immunotherapies, such as immune checkpoint inhibitors (ICI), have yielded limited benefit for most types of soft tissue sarcoma (STS). Radiotherapy (RT) is a mainstay of sarcoma therapy and can induce immune modulatory effects. Combining immunotherapy and RT in STS may be a promising strategy to improve sarcoma response to RT and increase the efficacy of immunotherapy. Most combination strategies have employed immunotherapies, such as ICI, that derepress immune suppressive networks...
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38508787/immunotherapy-and-radiotherapy-combinations-for-sarcoma
#9
REVIEW
Qian S Zhang, John P Hayes, Vinai Gondi, Seth M Pollack
Sarcomas are a heterogeneous group of bone and soft tissue tumors. Survival outcomes for advanced (unresectable or metastatic) disease remain poor, so therapeutic improvements are needed. Radiotherapy plays an integral role in the neoadjuvant and adjuvant treatment of localized disease as well as in the treatment of metastatic disease. Combining radiotherapy with immunotherapy to potentiate immunotherapy has been used in a variety of cancers other than sarcoma, and there is opportunity to further investigate combining immunotherapy with radiotherapy to try to improve outcomes in sarcoma...
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38508786/flash-radiotherapy-what-can-flash-s-ultra-high-dose-rate-offer-to-the-treatment-of-patients-with-sarcoma
#10
REVIEW
Keith A Cengel, Michele M Kim, Eric S Diffenderfer, Theresa M Busch
FLASH is an emerging treatment paradigm in radiotherapy (RT) that utilizes ultra-high dose rates (UHDR; >40 Gy)/s) of radiation delivery. Developing advances in technology support the delivery of UHDR using electron and proton systems, as well as some ion beam units (eg, carbon ions), while methods to achieve UHDR with photons are under investigation. The major advantage of FLASH RT is its ability to increase the therapeutic index for RT by shifting the dose response curve for normal tissue toxicity to higher doses...
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38508785/the-use-of-proton-and-carbon-ion-radiation-therapy-for-sarcomas
#11
REVIEW
Myrsini Ioakeim-Ioannidou, Melanie Rose, Yen-Lin Chen, Shannon M MacDonald
The unique physical and biological characteristics of proton and carbon ions allow for improved sparing of normal tissues, decreased integral dose to the body, and increased biological effect through high linear energy transfer. These properties are particularly useful for sarcomas given their histology, wide array of locations, and age of diagnosis. This review summarizes the literature and describes the clinical situations in which these heavy particles have advantages for treating sarcomas.
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38508784/opportunity-in-complexity-harnessing-molecular-biomarkers-and-liquid-biopsies-for-personalized-sarcoma-care
#12
REVIEW
Agnes Ewongwo, Caressa Hui, Everett J Moding
Due to their rarity and complexity, sarcomas represent a substantial therapeutic challenge. However, the incredible diversity within and across sarcoma subtypes presents an opportunity for personalized care to maximize efficacy and limit toxicity. A deeper understanding of the molecular alterations that drive sarcoma development and treatment response has paved the way for molecular biomarkers to shape sarcoma treatment. Genetic, transcriptomic, and protein biomarkers have become critical tools for diagnosis, prognostication, and treatment selection in patients with sarcomas...
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38508783/are-we-ready-for-life-in-the-fast-lane-a-critical-review-of-preoperative-hypofractionated-radiotherapy-for-localized-soft-tissue-sarcoma
#13
REVIEW
B Ashleigh Guadagnolo, Elizabeth H Baldini
This critical review aims to summarize the relevant published data regarding hypofractionation regimens for preoperative radiation therapy (RT) prior to surgery for soft tissue sarcoma (STS) of the extremity or superficial trunk. We identified peer-reviewed publications using a PubMed search on the MeSH headings of "soft tissue sarcoma" AND "hypofractionated radiation therapy." To obtain complication data on similar anatomical radiotherapeutic scenarios we also searched "hypofractionated radiation therapy" AND "melanoma" as well as "hypofractionated radiation therapy" AND "breast cancer...
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38508782/unraveling-the-myth-of-radiation-resistance-in-soft-tissue-sarcomas
#14
REVIEW
L M Wiltink, A B Miah, A N Scholten, R L Haas
There is a misconception that sarcomas are resistant to radiotherapy. This manuscript summarizes available (pre-) clinical data on the radiosensitivity of soft tissue sarcomas. Currently, clinical practice guidelines suggest irradiating sarcomas in 1.8-2 Gy once daily fractions. Careful observation of myxoid liposarcomas patients during preoperative radiotherapy led to the discovery of this subtype's remarkable radiosensitivity. It resulted subsequently in an international prospective clinical trial demonstrating the safety of a reduced total dose, yet still delivered with conventional 1...
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38508781/progress-in-retroperitoneal-sarcoma-management-surgical-and-radiotherapy-approaches
#15
REVIEW
Hiba Othman, Joel Shapiro, Peter Chung, Rebecca A Gladdy
Surgical resection is the cornerstone of curative treatment for retroperitoneal sarcomas (RPS), aiming for complete excision, yet the complexity of RPS with its proximity to vital structures continues to lead to high local recurrence rates after surgery alone. Thus, the role of radiotherapy (RT) continues to be refined to improve local control, which remains an important goal to prevent RPS recurrence. The recently completed global randomized trial to evaluate the role of surgery with and without preoperative RT - STRASS1, did not demonstrate a significant overall benefit for neoadjuvant RT based on the pre-specified definition of abdominal recurrence-free survival, however, sensitivity analysis using a standard definition of local recurrence and analysis of outcomes by compliance to the RT protocol suggests histology-specific benefit in well- and some de-differentiated liposarcomas...
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38508780/extremity-and-truncal-soft-tissue-sarcoma-risk-assessment-and-multidisciplinary-management
#16
REVIEW
Alessandra Borghi, Alessandro Gronchi
Extremity and truncal soft tissue sarcomas are a heterogeneous group of rare cancers that arise from mesenchymal tissues. Hence, the adoption of tailored risk assessment and prognostication tools plays a crucial role in optimizing the decision-making for which of the many possible treatment strategies to select. Management of these tumors requires a multidisciplinary strategy, which has seen significant development in recent decades. Surgery has emerged as the primary treatment approach, with the main goal of achieving microscopic negative tumor margins...
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38508779/the-role-of-radiotherapy-in-the-contemporary-management-of-patients-with-sarcoma-opportunities-to-improve-patient-outcomes
#17
EDITORIAL
David G Kirsch
No abstract text is available yet for this article.
April 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38503969/utility-of-lef1-to-differentiate-desmoid-fibromatosis-from-its-histologic-mimics
#18
JOURNAL ARTICLE
Soma Jobbagy, Santiago Lozano-Calderon, John T Mullen, G Petur Nielsen, Yin P Hung, Ivan Chebib
Diagnosis of desmoid-type fibromatosis (DF) may be challenging on biopsy due to morphologic overlap with reactive fibrosis (scar) and other uniform spindle cell neoplasms. Evaluation of nuclear β-catenin, a surrogate of Wnt pathway activation, is often difficult in DF due to weak nuclear expression and high background membranous/cytoplasmic staining. Lymphoid enhancer-factor 1 (LEF1) is a recently characterized effector partner of β-catenin which activates the transcription of target genes. We investigated the performance of LEF1 and β-catenin immunohistochemistry in a retrospective series of 156 soft tissue tumors, including 35 DF, 3 superficial fibromatosis, and 121 histologic mimics (19 soft tissue perineurioma, 8 colorectal perineurioma, 4 intraneural perineurioma, 26 scars, 23 nodular fasciitis, 6 low-grade fibromyxoid sarcomas, 6 angioleiomyomas, 5 neurofibromas, 5 dermatofibrosarcoma protuberans, 3 low-grade myofibroblastic sarcomas, 3 synovial sarcomas, 3 inflammatory myofibroblastic tumors, 2 schwannomas, and 1 each of Gardner-associated fibroma, radiation-associated spindle cell sarcoma, sclerotic fibroma, dermatofibroma, and glomus tumor)...
March 19, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38501816/extraosseous-ewing-s-sarcoma-of-the-pancreas
#19
JOURNAL ARTICLE
María Luisa López García, Nicolás Felipe Prado Troya, Leire Irusta Olano, María Paz Arreba González, Ainara Merino Zubizarreta, Ángel José Calderón García, Rosa Irene Alvarado Cuenca, Maite Zufiaurre Echavarri
We present the clinical case of a 21-year-old male with abdominal pain in the left hypochondrium radiating to the ipsilateral lumbar area and a weight loss of 2kg over a month, secondary to a large palpable intra-abdominal mass in the examination. TAC revealed a large solid mass with necrotic-cystic component which depended of the pancreas, infiltrated the spleen, enveloped the celiac trunk and affected to the splenic vases. Inmunohistochemical and molecular study confirmed the diagnosis extraosseus Ewing sarcoma (EES)...
March 19, 2024: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/38501158/proton-beam-therapy-for-clival-chordoma-optimising-rare-cancer-treatments-in-australia
#20
REVIEW
Ashwathy Mathew, Peter Gorayski, Nicholas Candy, Frank Saran, Hien Le
With the anticipated launch of the Australian Bragg Centre for Proton Therapy and Research (ABCPTR) in Adelaide, Australia, proton therapy will become a significant addition to existing cancer treatment options for Australians. The anticipated benefits will be particularly evident in rare cancers such as clival chordomas, a challenging tumour entity due to the anatomical relationship with critical structures, and proven radio-resistance to conventional radiation therapy. The article synthesises key findings from major studies and evaluates the current evidence supporting various management strategies for clival chordomas...
March 19, 2024: Journal of Medical Radiation Sciences
keyword
keyword
163700
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.