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https://www.readbyqxmd.com/read/28321424/cell-based-meniscus-repair-and-regeneration-at-the-brink-of-clinical-translation-a-systematic-review-of-preclinical-studies
#1
Jasmijn V Korpershoek, Tommy S de Windt, Michella H Hagmeijer, Lucienne A Vonk, Daniel B F Saris
BACKGROUND: Meniscus damage can be caused by trauma or degeneration and is therefore common among patients of all ages. Repair or regeneration of the menisci could be of great importance not only for pain relief or regaining function but also to prevent degenerative disease and osteoarthritis. Current treatment does not offer consistent long-term improvement. Although preclinical research focusing on augmentation of meniscal tear repair and regeneration after meniscectomy is encouraging, clinical translation remains difficult...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28321423/the-anterolateral-ligament-an-anatomic-study-on-sex-based-differences
#2
Matt Daggett, Camilo Helito, Matthew Cullen, Andrew Ockuly, Kyle Busch, Joseph Granite, Barth Wright, Bertrand Sonnery-Cottet
BACKGROUND: The anterolateral ligament (ALL) has been shown to have an important role in rotatory stability of the knee. While there is abundant research on sex-based differences related to anterior cruciate ligament (ACL) rupture, there is a paucity of literature related to such differences in the ALL. PURPOSE: To define any sex-based differences in the ALL with regard to length, width, and thickness. STUDY DESIGN: Descriptive laboratory study...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28318650/the-distribution-of-vascular-endothelial-growth-factor-in-human-meniscus-and-a-meniscal-injury-model
#3
Zhichao Lu, Takayuki Furumatsu, Masataka Fujii, Ami Maehara, Toshifumi Ozaki
BACKGROUND: The meniscus plays an important role in controlling the complex biomechanics of the knee. Meniscus injury is common in the knee joint. The perimeniscal capillary plexus supplies the outer meniscus, whereas the inner meniscus is composed of avascular tissue. Angiogenesis factors, such as vascular endothelial growth factor (VEGF), have important roles in promoting vascularization of various tissues. VEGF-mediated neovascularization is beneficial to the healing of injured tissues...
March 15, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28318635/the-application-of-infrared-imaging-and-optical-coherence-tomography-of-the-lacrimal-punctum-in-patients-undergoing-punctoplasty-for-epiphora
#4
Hannah M Timlin, Pearse A Keane, Geoffrey E Rose, Daniel G Ezra
PURPOSE: To determine the application of imaging the stenotic lacrimal punctum with infrared photographs and optical coherence tomography (OCT) and to identify characteristics of the lacrimal punctum in patients who benefit from punctoplasty. DESIGN: Case-control study. PARTICIPANTS: Twenty patients with epiphora who were listed for punctoplasty and 20 healthy controls. METHODS: Prospectively, 20 patients listed for punctoplasty were asked to rate their epiphora, using the Munk score, before and after punctoplasty...
March 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28318324/subchondral-bone-response-to-injected-adipose-derived-stromal-cells-for-treating-osteoarthritis-using-an-experimental-rabbit-model
#5
A Parrilli, G Giavaresi, A Ferrari, F Salamanna, G Desando, B Grigolo, L Martini, M Fini
Although articular cartilage is the target of osteoarthritis (OA), its deterioration is not always clearly associated with patient symptoms. Because a functional interaction between cartilage and bone is crucial, the pathophysiology of OA and its treatment strategy must focus also on subchondral bone. We investigated whether adipose-derived stromal cells (ASCs) injected into a joint at two different concentrations could prevent subchondral bone damage after the onset of mild OA in a rabbit model. We measured both volumetric and densitometric aspects of bone remodeling...
March 20, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28318066/three-dimensional-ultrashort-echo-time-cones-t1%C3%AF-3d-ute-cones-t1%C3%AF-imaging
#6
Ya-Jun Ma, Michael Carl, Hongda Shao, Anthony S Tadros, Eric Y Chang, Jiang Du
We report a novel three-dimensional (3D) ultrashort echo time (UTE) sequence employing Cones trajectory and T1ρ preparation (UTE-Cones-T1ρ ) for quantitative T1ρ assessment of short T2 tissues in the musculoskeletal system. A basic 3D UTE-Cones sequence was combined with a spin-locking preparation pulse for T1ρ contrast. A relatively short TR was used to decrease the scan time, which required T1 measurement and compensation using 3D UTE-Cones data acquisitions with variable TRs. Another strategy to reduce the total scan time was to acquire multiple Cones spokes (Nsp ) after each T1ρ preparation and fat saturation...
March 20, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28317846/serum-and-synovial-fluid-lipidomic-profiles-predict-obesity-associated-osteoarthritis-synovitis-and-wound-repair
#7
Chia-Lung Wu, Kelly A Kimmerling, Dianne Little, Farshid Guilak
High-fat diet-induced obesity is a major risk factor for osteoarthritis (OA) and diminished wound healing. The objective of this study was to determine the associations among serum and synovial fluid lipid levels with OA, synovitis, adipokine levels, and wound healing in a pre-clinical obese mouse model of OA. Male C57BL/6 J mice were fed either a low-fat (10% kcal) or one of three high-fat (HF, 60% kcal) diets rich in saturated fatty acids (SFAs), ω-6 or ω-3 polyunsaturated FAs (PUFAs). OA was induced by destabilization of the medial meniscus...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28314900/bony-landmark-between-the-attachment-of-the-medial-meniscus-posterior-root-and-the-posterior-cruciate-ligament-ct-and-mr-imaging-assessment
#8
Masataka Fujii, Takayuki Furumatsu, Shinichi Miyazawa, Yuya Kodama, Tomohito Hino, Yusuke Kamatsuki, Toshifumi Ozaki
OBJECTIVES: (1) To reveal the prevalence of the bony recess (posterior dimple) and (2) to determine the position of the posterior dimple on the tibial plateau using three-dimensional computed tomography (3DCT). MATERIALS AND METHODS: In this study, a retrospective review of 112 patients was performed to identify the posterior dimple and to evaluate its position on 3DCT. Magnetic resonance images (MRIs) were also used to determine the positional relationship among the posterior cruciate ligament (PCL), medial meniscus posterior insertion (MMPI), and posterior dimple...
March 18, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28314754/kdm6b-regulates-cartilage-development-and-homeostasis-through-anabolic-metabolism
#9
Jun Dai, Dongsheng Yu, Yafei Wang, Yishan Chen, Heng Sun, Xiaolei Zhang, Shouan Zhu, Zongyou Pan, Boon Chin Heng, Shufang Zhang, Hongwei Ouyang
OBJECTIVES: Epigenetic mechanisms have been reported to play key roles in chondrogenesis and osteoarthritis (OA) development. Here, we sought to identify specific histone demethylases that are involved and delineate the underlying mechanisms. METHODS: We screened the expression of 17 distinct histone demethylases by quantitative real time PCR (qRT-PCR) during chondrogenic differentiation of C3H10T1/2 cells. The role of Kdm6b in cartilage development was then analysed with transgenic Col2a1-CreER(T2);Kdm6b(f/f) ...
March 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28303971/magnetowetting-of-ferrofluidic-thin-liquid-films
#10
Srinivas Tenneti, Sri Ganesh Subramanian, Monojit Chakraborty, Gaurav Soni, Sunando DasGupta
An extended meniscus of a ferrofluid solution on a silicon surface is subjected to axisymmetric, non-uniform magnetic field resulting in significant forward movement of the thin liquid film. Image analyzing interferometry is used for accurate measurement of the film thickness profile, which in turn, is used to determine the instantaneous slope and the curvature of the moving film. The recorded video, depicting the motion of the film in the Lagrangian frame of reference, is analyzed frame by frame, eliciting accurate information about the velocity and acceleration of the film at any instant of time...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302532/randomized-controlled-crossover-trial-comparing-the-impact-of-sham-or-intranasal-neurostimulation-on-conjunctival-goblet-cell-degranulation
#11
Koray Gumus, Karri L Schuetzle, Stephen C Pflugfelder
PURPOSE: The aim of the study was to investigate the effects of the Oculeve Intranasal Lacrimal Neurostimulator (ILN) on conjunctival goblet cell degranulation. DESIGN: A randomized, double-masked, placebo-controlled crossover trial METHODS: A total of 15 subjects (5 normal and 10 dry eye) were enrolled in a three-visit study consisting of one screening and two separate randomized-masked ILN treatments (sham extranasal or intranasal). Tear meniscus height (TMH) was measured by AS-OCT before and after applications...
March 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28298056/outcomes-after-biologically-augmented-isolated-meniscal-repair-with-marrow-venting-are-comparable-with-those-after-meniscal-repair-with-concomitant-anterior-cruciate-ligament-reconstruction
#12
Chase S Dean, Jorge Chahla, Lauren M Matheny, Justin J Mitchell, Robert F LaPrade
BACKGROUND: Meniscal repair in the setting of anterior cruciate ligament (ACL) reconstruction has demonstrated superior outcomes compared with isolated meniscal repair. Limited evidence exists for the effects of biological augmentation in isolated meniscal repair, particularly as compared with meniscal repair with concomitant ACL reconstruction. Purpose/Hypothesis: The purpose of this study was to compare the outcomes and survivorship of meniscal repair in 2 cohorts of patients: meniscal repair with biological augmentation using a marrow venting procedure (MVP) of the intercondylar notch, and meniscal repair with concomitant ACL reconstruction...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28297876/active-microrheology-of-smectic-membranes
#13
Zhiyuan Qi, Kyle Ferguson, Yancey Sechrest, Tobin Munsat, Cheol Soo Park, Matthew A Glaser, Joseph E Maclennan, Noel A Clark, Tatiana Kuriabova, Thomas R Powers
Thin fluid membranes embedded in a bulk fluid of different viscosity are of fundamental interest as experimental realizations of quasi-two-dimensional fluids and as models of biological membranes. We have probed the hydrodynamics of thin fluid membranes by active microrheology using small tracer particles to observe the highly anisotropic flow fields generated around a rigid oscillating post inserted into a freely suspended smectic liquid crystal film that is surrounded by air. In general, at distances more than a few Saffman lengths from the meniscus around the post, the measured velocities are larger than the flow computed by modeling a moving disklike inclusion of finite extent by superposing Levine-MacKintosh response functions for pointlike inclusions in a viscous membrane...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28296429/factors-that-predict-failure-in-anatomic-single-bundle-anterior-cruciate-ligament-reconstruction
#14
Ben Parkinson, Curtis Robb, Michael Thomas, Peter Thompson, Tim Spalding
BACKGROUND: Anatomic graft placement in anterior cruciate ligament (ACL) reconstruction has become the preferred technique for many surgeons. The predictive factors for graft failure in anatomic single-bundle ACL reconstruction are relatively unknown. PURPOSE: To determine the risk factors for graft failure and the relative importance of those factors in anatomic single-bundle ACL reconstruction. STUDY DESIGN: Case-control study; Level of evidence, 3...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28293698/anterolateral-ligament-abnormalities-are-associated-with-peripheral-ligament-and-osseous-injuries-in-acute-ruptures-of-the-anterior-cruciate-ligament
#15
Camilo Partezani Helito, Paulo Victor Partezani Helito, Renata Vidal Leão, Marco Kawamura Demange, Marcelo Bordalo-Rodrigues
PURPOSE: Few studies have used MRI to identify the ALL. As it was shown that it is not possible to precisely characterize this ligament in all examination, it is important to identify concomitant lesions that can help in diagnosing ALL abnormalities. It is important to characterise this injury due to its association with anterolateral knee instability. Thus, the present study was performed to determine the frequency of ALL injuries in patients with acute ACL rupture and to analyse its associated knee lesions...
March 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28289817/the-all-inside-meniscal-repair-technique-has-less-risk-of-injury-to-the-lateral-geniculate-artery-than-the-inside-out-repair-technique-when-suturing-the-lateral-meniscus
#16
Adrián Cuéllar, Ricardo Cuéllar, Jorge Díaz Heredia, Asier Cuéllar, Ignacio García-Alonso, Miguel Angel Ruiz-Ibán
PURPOSE: To evaluate the risk of injury to the inferior lateral geniculate artery with two different techniques for lateral meniscus repair. METHODS: Eight cadaveric knees were used. Inside-out sutures and an all-inside suture device were placed at the most lateral edge of the popliteal hiatus, and 15 and 30 mm anterior to this point. The minimum distances between the sutures and the inferior lateral geniculate artery were measured through a limited lateral arthrotomy...
March 13, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28282214/clinical-and-radiographic-outcomes-of-meniscus-surgery-and-future-targets-for-biologic-intervention-a-review-of-data-from-the-moon-group
#17
Robert W Westermann, Morgan Jones, David Wasserstein, Kurt P Spindler
Meniscus injury and treatment occurred with the majority of anterior cruciate ligament reconstructions (ACLR) in the multicenter orthopaedic outcomes (MOON) cohort. We describe the patient reported outcomes, radiographic outcomes and predictors of pain from meniscus injuries and treatment in the setting of ACLR. Patient reported outcomes improve significantly following meniscus repair with ACLR, but differences exist based on the meniscus injury laterally (medial or lateral). Patients undergoing medial meniscus repair have worse patient-reported outcomes and more pain compared to those with uninjured menisci...
March 10, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28278525/erratum-the-relationship-between-body-mass-index-and-risk-of-failure-following-meniscus-repair
#18
Mark F Sommerfeldt, Robert A Magnussen, Kyle L Randall, Marc Tompkins, Bryan Perkins, Avijit Sharma, Ryan Blackwell, David C Flanigan
No abstract text is available yet for this article.
March 9, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28274121/dynamics-of-capillary-driven-flow-in-3d-printed-open-microchannels
#19
Robert K Lade, Erik J Hippchen, Christopher W Macosko, Lorraine F Francis
Microchannels have applications in microfluidic devices, patterns for micromolding, and even flexible electronic devices. Three-dimensional (3D) printing presents a promising alternative manufacturing route for these microchannels due to the technology's relative speed and the design freedom it affords its users. However, the roughness of 3D printed surfaces can significantly influence flow dynamics inside of a microchannel. In this work, open microchannels are fabricated using four different 3D printing techniques: fused deposition modeling (FDM), stereolithography (SLA), selective laser sintering, and multi jet modeling...
March 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28272930/risk-factors-associated-with-knee-joint-degeneration-after-arthroscopic-reshaping-for-juvenile-discoid-lateral-meniscus
#20
Shinya Yamasaki, Yusuke Hashimoto, Junsei Takigami, Shozaburo Terai, Shinji Takahashi, Hiroaki Nakamura
BACKGROUND: Although arthroscopic meniscal reshaping for discoid lateral meniscus (DLM) has better outcomes than total or subtotal meniscectomy, degenerative changes on radiographs are still seen in some patients with meniscal reshaping. PURPOSE: To assess the risk factors associated with knee joint degeneration after reshaping surgery for juvenile DLM. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Forty patients (45 knees) with a mean age of 12...
March 2017: American Journal of Sports Medicine
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