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anogenital neoplasia

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https://www.readbyqxmd.com/read/30054550/evaluation-and-validation-of-hpv-real-time-pcr-assay-for-the-detection-of-hpv-dna-in-oral-cytobrush-and-ffpe-samples
#1
Alexandre Harlé, Julie Guillet, Jacques Thomas, Xavier Sastre-Garau, Marie Rouyer, Carole Ramacci, Pauline Gilson, Cindy Dubois, Gilles Dolivet, Agnès Leroux, Julia Salleron, Jean-Louis Merlin
Specific HPV genotypes have been recognized as risk factors inducing head and neck cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect accurately High Risk HPV DNA in Formalin Fixed Paraffin Embedded (FFPE) and oral cytobrush samples and compare the results with conventional PCR. Repeatability, reproducibility and limit of detection of Cobas assay were estimated for oral cytobrush and FFPE samples of patients with HNC. 53 samples of patients with a HNC were then used for assay comparison with conventional PCR...
July 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30016957/efficacy-effectiveness-and-safety-of-vaccination-against-human-papillomavirus-in-males-a-systematic-review
#2
Thomas Harder, Ole Wichmann, Stefanie J Klug, Marianne A B van der Sande, Miriam Wiese-Posselt
BACKGROUND: Human papillomavirus (HPV) vaccination is safe and effective in preventing cervical cancer in females. As HPV infections can also induce cancers of the anus, penis and oral cavity, male vaccination is also advocated, but systematic reviews on efficacy and safety in males are lacking. METHODS: We performed a systematic review on the efficacy, effectiveness and safety of HPV vaccination in males of any age. MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and ClinicalTrials...
July 18, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29995724/human-papillomavirus-genotypes-from-vaginal-and-vulvar-intraepithelial-neoplasia-in-females-15-26-years-of-age
#3
Suzanne M Garland, Elmar A Joura, Kevin A Ault, F Xavier Bosch, Darron R Brown, Xavier Castellsagué, Alex Ferenczy, Daron G Ferris, Anna R Giuliano, Mauricio Hernandez-Avila, Warner K Huh, Ole-Erik Iversen, Susanne K Kjaer, Robert J Kurman, Joaquin Luna, Joseph Monsonego, Nubia Muñoz, Jorma Paavonen, Punnee Pitisuttihum, Brigitte M Ronnett, Marc Steben, Mark H Stoler, Cosette M Wheeler, Dorothy J Wiley, Gonzalo Perez, Alfred J Saah, Alain Luxembourg, Se Li, Mark J DiNubile, Monika Wagner, Christine Velicer
OBJECTIVE: To estimate the proportion of vulvar and vaginal low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) in females 15-26 years of age attributable to 14 human papillomavirus (HPV) genotypes (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59). METHODS: A post hoc analysis of prospectively diagnosed vulvar and vaginal LSILs and HSILs among females 15-26 years of age enrolled in the placebo arms of two phase 3, randomized HPV vaccine trials assessed 14 prespecified HPV genotypes associated with cervical cancers or anogenital warts using a type-specific multiplex polymerase chain reaction assay...
August 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29848037/ocular-human-papillomavirus-infections
#4
Mehenaz Hanbazazh, Kymberly A Gyure
CONTEXT: - Human papillomavirus (HPV) has a well-known role in the pathogenesis of squamous cell carcinoma and precursor lesions of the cervix, anogenital region, and head and neck, but its role in the development of squamous neoplasms of the eye, particularly the conjunctiva, remains unclear. OBJECTIVE: - To review recent evidence implicating HPV in the pathophysiology of ocular lesions. DATA SOURCES: - Published articles obtained from a PubMed search of the English literature were the primary sources for this review...
June 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29723682/intra-host-sequence-variability-in-human-papillomavirus
#5
Racheal S Dube Mandishora, Kristina S Gjøtterud, Sonja Lagström, Babill Stray-Pedersen, Kerina Duri, Nyasha Chin'ombe, Mari Nygård, Irene Kraus Christiansen, Ole Herman Ambur, Mike Z Chirenje, Trine B Rounge
Human papillomaviruses (HPVs) co-evolve slowly with the human host and each HPV genotype displays epithelial tropisms. We assessed the evolution of intra HPV genotype variants within samples, and their association to anogenital site, cervical cytology and HIV status. Variability in the L1 gene of 35 HPV genotypes was characterized phylogenetically using maximum likelihood, and portrayed by phenotype. Up to a thousand unique variants were identified within individual samples. In-depth analyses of the most prevalent genotypes, HPV16, HPV18 and HPV52, revealed that the high diversity was dominated by a few abundant variants...
June 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29659752/performance-of-anal-cytology-compared-with-high-resolution-anoscopy-and-histology-in-women-with-lower-anogenital-tract-neoplasia
#6
Andreia Albuquerque, Michael Sheaff, Oliver Stirrup, Carmelina Cappello, Julie Bowring, Tamzin Cuming, Anke de Masi, Adam N Rosenthal, Mayura Nathan
Background: Information on the performance of anal cytology in women who are high-risk for human papillomavirus-related lesions and the factors that might influence it are largely lacking. Aims: Evaluate the performance of anal cytology in women with lower anogenital tract neoplasia. Methods: retrospective study including all new referrals of women with a previous history of anogenital neoplasia, from January 2012 to July 2017, with concomitant anal cytology and high-resolution anoscopy with or without biopsies...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29593938/oropharynx-hpv-status-and-its-relation-to-hiv-infection
#7
Leonora Maciel de Souza Vianna, Fabiana Pirani Carneiro, Rivadavio Amorim, Eliete Neves da Silva Guerra, Florêncio Figueiredo Cavalcanti Neto, Valdenize Tiziani, Andrea Barretto Motoyama, Anamélia Lorenzetti Bocca
Background: The number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx HPV infection in these patients is not clear. The aim of the present study was to detect HPV infection, and clinical and cytological changes in the oropharynx of HIV-positive patients. Methods: Samples collected from the oropharynx of 100 HIV-positive patients were subjected to hybrid capture (HC), conventional and liquid-based cytology...
2018: PeerJ
https://www.readbyqxmd.com/read/29570565/p16-immunohistochemistry-is-not-always-required-for-accurate-diagnosis-of-grade-2-squamous-intraepithelial-lesions
#8
Lulu Sun, Lingxin Zhang, Hannah R Krigman, Ian S Hagemann
OBJECTIVES: Preinvasive squamous neoplasms of the lower genital tract are currently classified using a two-tier system (high- or low-grade squamous intraepithelial lesion) as directed by the Lower Anogenital Squamous Terminology (LAST) guidelines but may also be subclassified as intraepithelial neoplasia grade 1 (-IN1), -IN2, or -IN3. The LAST recommended that all diagnoses of -IN2 be supported by immunohistochemistry (IHC) for p16. We examined whether p16 and Ki-67 IHC are necessary to diagnose -IN2 when the lesion has obvious high-grade histology...
April 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29434342/p16-immunostaining-in-histological-grading-of-anal-squamous-intraepithelial-lesions-a-systematic-review-and-meta-analysis
#9
Andreia Albuquerque, Elisabete Rios, Claudia Camila Dias, Mayura Nathan
p16 is the most widely studied biomarker in lower anogenital tract squamous intraepithelial lesions and, currently the only recommended biomarker for histological grade assessment. The aim of this systematic review and meta-analysis was to evaluate p16-positive rates according to anal squamous intraepithelial lesions/anal intraepithelial neoplasia (AIN) grade. Two investigators independently searched four electronic databases: PubMed, Web of Sciences, Scopus, and Embase from inception until August 2017. Studies that evaluated p16 immunostaining in histological samples of anal and/or perianal squamous intraepithelial lesions and defined a p16-positive result as diffuse block staining with nuclear or nuclear plus cytoplasmic staining were included...
February 13, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29204065/anal-cancer-and-anal-cancer-precursors-in-women-with-a-history-of-hpv-related-dysplasia-and-cancer
#10
Elizabeth A Stier, Elizabeth Y Chiao
The epidemiology of anal cancer in the U.S. has changed over the past 3 decades. During this period the incidence of anal cancer has increased among both men and women. Of note, women with a history of anogenital HPV infection are at higher risk than the general population for anal cancer. The increased risk ranged from increased incidence rate ratios ranging from 1.82 to 6.3 in women with a history of cervical cancer, to 4.2-16.4 in women with a history of prior cervical intraepithelial neoplasia 3 (CIN 3)...
June 2017: Seminars in Colon & Rectal Surgery
https://www.readbyqxmd.com/read/29112019/utility-of-p16-immunohistochemistry-in-evaluating-negative-cervical-biopsies-following-high-risk-pap-test-results
#11
Alana F Shain, Shirley Kwok, Ann K Folkins, Christina S Kong
The Lower Anogenital Squamous Terminology (LAST) Standardization Project for human papilloma virus (HPV)-associated lesions specifically recommends the use of p16 immunohistochemistry (IHC) as an adjunct to morphologic assessment of cervical biopsies interpreted as negative or low-grade squamous intraepithelial lesion (LSIL) from patients with prior high-risk Pap test results (high-grade squamous intraepithelial lesion [HSIL], atypical squamous cells cannot exclude HSIL, atypical glandular cells [AGC], or HPV16 atypical squamous cells of undetermined significance [ASC-US])...
January 2018: American Journal of Surgical Pathology
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