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Danka Pokrajac, Irmina Sefic-Pasic, Amela Begic
Introduction: The objective of this research was to determine whether vesicoureteral reflux(VUR) was associated with evolution to renal scarring (RS) following a febrile urinary tract infection (UTI) in infants. Materials and methods: Our research included 100 infants, ages up to 1 year with a first febrile UTI. The diagnostic was based on results of: laboratory findings, ultrasonography (USG), voiding cystourethrography (VCUG) and initial and control renal scintigraphy (DMSA renal scan) withtechnetium99m Tcsuccimer (dimercaptosuccinic acid), to assess the acute pyelonephritis (APN), VUR and RS...
October 2018: Medical Archives
Bongyoung Kim, Rangmi Myung, Jieun Kim, Myoung-Jae Lee, Hyunjoo Pai
Background: Acute pyelonephritis (APN) is one of the most common community-acquired bacterial infections. Recent increases of antimicrobial resistance in urinary pathogens might have changed the other epidemiologic characteristics of APN. The objective of this study was to describe the current epidemiology of APN in Korea, using the entire population. Methods: From the claims database of the Health Insurance Review and Assessment Service in Korea, the patients with International Classification of Diseases, 10th Revision codes N10 (acute tubulo-interstitial nephritis) or N12 (tubulo-interstitial nephritis, neither acute nor chronic) as the primary discharge diagnosis during 2010-2014 were analyzed, with two or more claims during a 14-day period considered as a single episode...
December 3, 2018: Journal of Korean Medical Science
Weihong Li, Lihong Geng, Xiru Liu, Wenwu Gui, Hongbo Qi
Recurrent spontaneous abortion (RSA) is associated with abnormal maternal tolerance to the semi-allogenic fetus, wherein the Th17/Treg axis plays a crucial role. Adiponectin (APN) is an adipocytokine that is shown to be a novel negative T-cell regulator and induce immune tolerance. The CBA/J × DBA/2 mating was used as an abortion-prone model to investigate whether the addition of recombinant adiponectin (rAPN) improves the pregnancy outcome. rAPN therapy reduced the abortion rate in abortion-prone model...
November 28, 2018: Biology of Reproduction
Heather Cuevas, Catherine Ward
RATIONALE, AIMS, AND OBJECTIVES: The risk of cognitive dysfunction is higher in people with diabetes than in the general population, and approximately 50% of those with diabetes will develop cognitive impairments as they age. Screening for cognitive dysfunction in people with diabetes can help identify both pathology and those who are at risk for higher health care utilization, but we do not know how health care providers implement cognitive screening recommendations in this population...
November 29, 2018: Journal of Evaluation in Clinical Practice
Hua Jiang, Yuwei Wu, Paloma Valverde, Dana Murray, Jin Tang, Qi Yao, Qianqian Han, Jin Zhang, Lan Zhang, Lei Sui, Yin Tang, Qisheng Tu, Jake Chen
Central adiponectin (APN) in either the globular (gAPN) or full-length forms decreases sympathetic tone and increases trabecular bone mass in mice through the hypothalamus. It is known that cannabinoid type-1 (CB1) receptors are expressed in the hypothalamic ventromedial nucleus and participate in energy metabolism by controlling sympathetic activity. However, whether central APN could influence endocannabinoid signaling through CB1 receptor to regulate bone metabolism has not been characterized. Here we demonstrate that gAPN downregulated CB1 expression in embryonic mouse hypothalamus N1 cells in vitro...
November 27, 2018: Journal of Cellular Physiology
Feng Tian, Zhigang Zheng, Damin Zhang, Si He, Jie Shen
Type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD) is difficult to treat. This study explored the efficacy of liraglutide in treating T2DM complicated with NAFLD. A total of 127 patients suffering from T2DM complicated with NAFLD were enrolled in this study, and randomly assigned to a Lira group (liraglutide injection: 0.6-1.2 mg/day, 12 weeks, n = 52) or a Met group (oral metformin: 1000-1500 mg/day, 12 weeks, n = 75). During the treatment phase, the values for fasting plasma glucose (FPG), 2 h plasma glucose (2hPG), glycated hemoglobin (HbA1c), Aspartate aminotransferase (AST)/alanine aminotransferase (ALT), and adiponectin (APN) decreased in both the Lira and Met groups, and the levels of Δ2hPG, ΔAST/ALT, and ΔAPN in the Lira group were significantly lower than those in the Met group...
November 25, 2018: Bioscience Reports
Agnieszka Baranowska, Beata Skowron, Krzysztof Gil, Jolanta Kaszuba-Zwoińska
OBJECTIVE: The main goal of our studies was to investigate the effect exerted by pulsed electromagnetic led (PEMF) on adipocytokines secretion in cell culture supernatants from rat adipose derived stem cells (ADSCs) grown on varied energy-rich diet. O spring and adult animals were randomly selected for two types of experimental diets: low (LF) or high fat (HF) diet for 7 weeks. A er the diet period, serum glucose level was measured, ADSCs were isolated from adipose tissues from different locations...
2018: Folia Medica Cracoviensia
Jingjie Xiao, Lei Wu, Wei Zhang, Liang Zhang, Yang Wang, Li Li, Xinzhi Li, Ketao Ma
Objective To investigate the protective effects and mechanism of adiponectin (APN) on RAW264.7 macrophages under cell model of hypoxia established by CoCl2 . Methods Cells were treated with CoCl2 (100 μmol/L) and different concentrations of APN (0.5, 1, 2 μg/mL APN, pretreated for 2 hours firstly, and treated with CoCl2 in a dose of 100 μmol/L). The cells' vitality in each group was detected by CCK-8 assay. The distribution of caspase-3, as well as the influences of CoCl2 and APN on the expression of caspase-3 was detected by immunofluorescence technique...
September 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
Masahiro Miyaji, Yuichiro Hayashi, Masafumi Funakoshi, Akihiro Tanaka, Qiu-Mei Zhang-Akiyama
AP endonuclease deficiency causes cell death and embryonic lethality in mammals. However, the physiological roles of AP endonucleases in multicellular organisms remain unclear, especially after embryogenesis. Here, we report novel physiological roles of the AP endonuclease EXO-3 from larval to adult stages in Caenorhabditis elegans, and elucidated the mechanism of the observed phenotypes due to EXO-3 deficiency. The exo-3 mutants exhibited developmental delay, whereas the apn-1 mutants did not. The delay depended on the DNA glycosylase NTH-1 and checkpoint kinase CHK-2...
November 13, 2018: Scientific Reports
Junhua Yang, Guanghui Du, Jinyu Wang, Jia Chen, Chenghui Yang, Jia Li, Yun Zhang
BACKGROUND AND AIMS: Decreased adiponectin (APN) level has been indicated to be associated with depression. In the present study, we aimed to investigate whether serum APN could predict poststroke depression (PSD) at 3 months in patients with acute ischemic stroke. METHOD: Patients with first-ever ischemic stroke and hospitalized within 24 hours of symptoms onset were enrolled prospectively during March 2017 to September 2017. Serum APN level was measured at admission by enzyme-linked immunosorbent assay...
October 31, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Arlen Peña-Cardeña, Ricardo Grande, Jorge Sánchez, Bruce E Tabashnik, Alejandra Bravo, Mario Soberón, Isabel Gómez
Bacillus thuringiensis (Bt) Cry toxins are used worldwide for controlling insects. Cry1Ab is produced as a 130 kDa protoxin that is activated by proteolytic removal of an inert 500 amino-acids-long C-terminal region, enabling the activated toxin to bind to insect midgut receptor proteins and leading to its membrane insertion and pore formation. It has been proposed that the C-terminal region is only involved in toxin crystallization, but its role in receptor binding is undefined. Here we show that the C-terminal region of Cry1Ab protoxin provides additional binding sites to alkaline phosphatase (ALP) and aminopeptidase N (APN) insect receptors...
November 1, 2018: Journal of Biological Chemistry
María Jesús Ramírez-Expósito, José Manuel Martínez-Martos
BACKGROUND: It has been described that doxazosin, an antihypertensive drug, also promotes glioblastoma cells death by inhibiting cell proliferation, arresting cell cycle and inducing apoptosis. Doxazosin has also demonstrated several modulator effects on renin-angiotensin system (RAS)-regulating aminopeptidase activities, which are highly involved in tumor growth in experimental glioma. Therefore, it remains to elucidate if the anti-tumoral effects of doxazosin could be also mediated by the proteolytic regulatory components of the RAS...
October 29, 2018: CNS & Neurological Disorders Drug Targets
Na-Young Kang, Julijana Ivanovska, Liran Tamir-Hostovsky, Jaques Belik, Estelle B Gauda
Premature infants have chronic intermittent hypoxia (CIH) that increases morbidity, and the youngest and the smallest premature infants are at the greatest risk. The combination of lung injury from inflammation/oxidative stress causing low functional residual capacity combined with frequent short apneas leads to CIH. Adiponectin (APN) is an adipose-derived adipokine that protects the lung from inflammation and oxidative stress. Premature and small for gestational age (SGA) infants have minimal body fat and low levels of circulating APN...
2018: Advances in Experimental Medicine and Biology
Silvia Raphaelis, Hanna Mayer, Stefan Ott, Rene Hornung, Beate Senn
OBJECTIVES: To determine whether written information and/or counseling decreases illness-related uncertainty in women with vulvar neoplasia. SAMPLE & SETTING: 49 women with vulvar neoplasia from four Swiss hospitals and one Austrian hospital. METHODS & VARIABLES: A longitudinal, multicenter, randomized phase 2 study was performed. The written information group received a set of leaflets. The counseling group received five consultations with an advanced practice nurse (APN) from diagnosis to six months postsurgery that focused on symptom self-management, healthcare services, and decision making...
November 1, 2018: Oncology Nursing Forum
G-Z Ding, W-S Li
OBJECTIVE: Inflammatory reactions and imbalance of oxidant/antioxidant and protease/anti-protease are the major causes of chronic obstructive pulmonary disease. Based on the information mentioned, the expressions and significance of adiponectin (APN), D-dimer (DD), Interleukin (IL)-17, and high-sensitivity CRP (hs-CRP) in patients with acute exacerbation of chronic obstructive pulmonary disease were investigated in this study. PATIENTS AND METHODS: A total of 70 patients with chronic obstructive pulmonary disease were enrolled and divided into stable group (group A, 28 cases) and acute exacerbation group (group B, 42 cases)...
October 2018: European Review for Medical and Pharmacological Sciences
A L B Moreira Filho, P R Ferket, R D Malheiros, C J B Oliveira, P C Aristimunha, D E Wilsmann, P E N Givisiez
The effects of in ovo feeding with threonine (Thr) on intestinal morphology, ileal gene expression and performance of broiler chicken between 1 and 21 d of age (d) were assessed. On day 17.5 of incubation, fertile eggs were randomly allotted to 5 treatments of Thr injection in the amniotic fluid (0; 1.75; 3.5; 5.25; 7%, corresponding to 17.5; 35; 52.5 and 70 mg Thr/mL). After hatch, chicks were given a commercial corn-soybean diet up to 21 d. Daily feed intake (FI), body weight (BW), and food conversion ratio (FCR) were measured from 1 to 7, 14, and 21 d of age...
October 15, 2018: Poultry Science
Imen Gorsane, Sana Barrah, Samia Barbouch, Hayet Kaaroud, Amel Harzallah, Taieb Ben Abdallah
INTRODUCTION: Acute pyelonephritis (APN) results from bacterial invasion of the renal parenchyma. The aim of this study was to investigate the epidemiological, clinico-biological, therapeutic and evolutionary APN and to identify the risk factors of this renal disease. METHODS: We conducted a retrospective and descriptive study, over a period of 37 years (1977-2014), including 43 patients with APN, hospitalized in our Department. RESULTS: There were 43 patients with mean age of 36...
January 2018: La Tunisie Médicale
Emmanuel Salomon, Marjorie Schmitt, Anil Kumar Marapaka, Athanasios Stamogiannos, Germain Revelant, Céline Schmitt, Sarah Alavi, Isabelle Florent, Anthony Addlagatta, Efstratios Stratikos, Céline Tarnus, Sébastien Albrecht
The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield. In order to investigate their specificity, series of enzyme inhibition assays were carried out against a diversity of proteases, covering representative members of aspartic, cysteine, metallo and serine endopeptidases and including eight members of the monometallic M1 family of aminopeptidases as well as two members of the bimetallic M17 and M28 aminopeptidase families...
October 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Bruno Moulin, Thierry Ponchon
Background and study aims  Colonoscopy is a widely used diagnostic procedure which requires prior cleansing of the bowel. Many different bowel cleansing preparations have been developed, all of which have specific advantages and disadvantages. This review compares two low-volume high-osmolarity bowel cleansing preparations, oral phosphate salts and oral sulphate salts, with a particular focus on risk of nephrotoxicity. Patients and methods  An electronic search of the Medline database was performed using the search terms "(phosphates OR sulfates) AND cathartics [MeSH Term] AND kidney" restricted to humans with a cut-off date of December 31, 2016...
October 2018: Endoscopy International Open
X-S Qian, J-X Song, M-H Zhu
OBJECTIVE: To discuss the correlation between polymorphism of rs266729 (-11377C/G, Cytosine/Guanine) (adiponectin promoter) site and atherosclerotic plaque compositions as well as related indicators under intravascular ultrasound (IVUS). PATIENTS AND METHODS: 76 patients with coronary heart disease from December 2014 to December 2016 were enrolled. The PCR-RFLP method was used to analyze the adiponectin gene polymorphism in rs266729 site. All the objects were divided into CC type group (n=26), CG type group (n=23), and GG type group (n=27) according to the results of polymorphism...
September 2018: European Review for Medical and Pharmacological Sciences
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