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https://www.readbyqxmd.com/read/30322292/an-audit-of-performance-interpretation-and-influence-of-pretherapeutic-mri-in-rectal-cancer-a-swedish-population-based-cohort-study
#1
Anders H Elliot, Lennart Blomqvist, Arni Sigurdsson, Anna Martling, Hemming Johansson, Bengt Glimelius, Per J Nilsson
Background The performance of magnetic resonance imaging (MRI) interpretation and communication of findings and its implication on treatment decisions has not fully been explored in rectal cancer. Purpose To investigate in a region the adherence to MRI protocol standards and the relation between MRI interpretation and selection to preoperative therapy in rectal cancer. Material and Methods Data on consecutive patients who underwent elective rectal cancer surgery in the region from January to June 2010 were obtained from the National Colorectal Cancer Registry...
October 15, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/30319260/hpa-axis-genes-as-potential-risk-variants-for-neurocognitive-decline-in-trauma-exposed-hiv-positive-females
#2
Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian Mj Hemmings, Soraya Seedat
Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic-pituitary-adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 ( CRHR1 ; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein ( CRHBP ; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/30316664/nonmetal-clip-migration-after-laparoscopic-cholecystectomy-and-bile-duct-exploration-is-it-rare
#3
Yamin Zheng, Yuehua Wang, Xuesong Bai, Dongbin Liu, Fei Li
BACKGROUND: Nonmetal clip were applied to ligate cystic duct and gall bladder vessels as alternation for metal clip in cholecystectomy (LC) and laparoscopic bile duct exploration (LCBDE). This study aim to explore nonmetal clip migration cases after LC or LCBDE and make literature review. METHODS: This study reported six cases of nonmetal clip migration into the gastrointestinal tract or bile duct. Combined with previous literature, it was discussed about the possible risk factors, clinical presentations, outcomes and treatment...
October 10, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/30315367/stress-load-of-emergency-service-effects-on-the-car-and-hrv-of-hems-emergency-physicians-on-different-working-days-n-20
#4
Katja Petrowski, Benedict Herhaus, Christian Schöniger, Mark Frank, Jaroslaw Pyrc
PURPOSE: The occupation of the emergency physicians (EPs) of helicopter emergency medical services (HEMS) can be characterized as a high-strain occupation (Karasek in Adm Sci Q 24(2):285-308. https://doi.org/10.2307/2392498 , 1979). Therefore, the aim of this study was to measure and compare the stress load of the EPs of HEMS on duty on air ambulance workdays and on 2 control days. METHODS: In this field study (within-subjects design), hormonal, physiological, and self-perceived stress levels of 20 EPs [3 females, 17 males; mean age (M) = 44...
October 12, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/30314976/external-validity-is-also-an-ethical-consideration-in-cluster-randomised-trials-of-policy-changes-the-author-s-reply
#5
Karla Hemming
No abstract text is available yet for this article.
October 12, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/30312878/corrigendum-to-synthesis-of-glyceryl-glycosides-related-to-a-type-prymnesin-toxins-carbohydr-res-463-2018-14-23
#6
Edward S Hems, Sergey A Nepogodiev, Martin Rejzek, Robert A Field
No abstract text is available yet for this article.
October 9, 2018: Carbohydrate Research
https://www.readbyqxmd.com/read/30311608/cuaac-click-chemistry-for-the-enhanced-detection-of-novel-alkyne-based-natural-product-toxins
#7
Edward S Hems, Ben A Wagstaff, Gerhard Saalbach, Robert A Field
In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.
October 12, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/30308615/implant-based-breast-reconstruction-with-acellular-dermal-matrix-safety-data-from-an-open-label-multicenter-randomized-controlled-trial-in-the-setting-of-breast-cancer-treatment
#8
Fredrik Lohmander, Jakob Lagergren, Pankaj G Roy, Hemming Johansson, Yvonne Brandberg, Catharina Eriksen, Jan Frisell
OBJECTIVE: To evaluate clinical outcomes of using acellular dermal matrix (ADM) with implant based breast reconstructions (IBBRs) in a randomized controlled trial. SUMMARY BACKGROUND DATA: The use of ADMs in IBBRs is widespread, but link between ADM and complications remain a controversial topic. In view of reports concerning harm, we present 6-months safety data of ADM-assisted IBBR in the setting of breast cancer treatment. METHODS: An open-label, randomized, controlled trial recruiting patients from 4 centers in Sweden and 1 in UK...
October 10, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/30299527/-introduction-of-prehospital-blood-transfusion-programme-in-sweden-experiences-from-a-physician-staffed-helicopter-emergency-medical-service
#9
José-Gabriel Sato Folatre, Per Arnell, Mari Henning, Kristina Josefsson, Gabriel Skallsjö, Sven-Erik Ricksten
In 2016, physician staffed helicopter emergency medical service (VGR HEMS) became the first Swedish prehospital service to routinely carry and transfuse red blood cells. In this report we describe our implementation and present our results, with preliminary analysis of our data. Out of 1 336 patients a total of 34 patients (2,5 %) were transfused without any adverse events. Our demography is predominantly male and the most common mechanism of injury is trauma. Amongst the most common interventions were endotracheal intubation, thoracostomy and CPR...
October 2, 2018: Läkartidningen
https://www.readbyqxmd.com/read/30296878/treatment-transport-and-primary-care-involvement-when-helicopter-emergency-medical-services-are-inaccessible-a-retrospective-study
#10
Dag Ståle Nystøyl, Steinar Hunskaar, Hans Johan Breidablik, Øyvind Østerås, Erik Zakariassen
OBJECTIVE: To examine handling of cancelled helicopter emergency medical services (HEMS) missions with a persisting medical indication. DESIGN: Retrospective observational study. SETTING AND SUBJECTS: Cancelled HEMS missions with persisting medical indication within Sogn og Fjordane county in Norway during the period of 2010-2013. Both primary and secondary missions were included. MAIN OUTCOME MEASURES: Primary care involvement, treatment and cooperation within the prehospital system...
October 8, 2018: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/30289327/long-term-quality-of-life-after-comprehensive-surgical-staging-of-high-risk-endometrial-cancer-results-from-the-rashec-trial
#11
Sahar Salehi, Yvonne Brandberg, Elisabeth Åvall-Lundqvist, Chikako Suzuki, Hemming Johansson, Berit Legerstam, Henrik Falconer
PURPOSE: The health-related quality of life (HRQoL) outcomes after comprehensive surgical staging including infrarenal paraaortic lymphadenectomy in women with high-risk endometrial cancer (EC) are unknown. Our aim was to investigate the long-term HRQoL between robot-assisted laparoscopic surgery (RALS) and laparotomy (LT). PATIENTS AND METHODS: A total of 120 women with high-risk stage I-II EC were randomised to RALS or LT for hysterectomy, bilateral salpingoophorectomy, pelvic and infrarenal paraaortic lymphadenectomy in the previously reported Robot-Assisted Surgery for High-Risk Endometrial Cancer trial...
October 5, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/30284113/robotic-assisted-laparoscopic-apical-suspension-description-of-the-spiral-technique
#12
Hugo H Davila, Karisa Brown, Prajwal Dara, Lindsey Bruce, Lindsey Goodman, Taryn Gallo
This video's objective was to describe our spiral technique and surgical steps of robotic-assisted laparoscopic apical suspension (RALAS) in the treatment of patients with symptomatic apical vaginal prolapse. A 70-year-old Caucasian woman, gravida 3, para 2 had symptomatic pelvic organ prolapse (POP) apical/anterior stage III. At pelvic ultrasound evaluation, the uterus was small and normal appearing of adnexa bilaterally. She failed pessaries and is sexually active. The most relevant complaints were vaginal bulging and pressure...
October 3, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/30283471/the-hem-lines-a-new-library-of-homozygous-arabidopsis-thaliana-ems-mutants-and-its-potential-to-detect-meiotic-phenotypes
#13
Laia Capilla-Perez, Victor Solier, Virginie Portemer, Aurelie Chambon, Aurelie Hurel, Alexia Guillebaux, Daniel Vezon, Laurence Cromer, Mathilde Grelon, Raphael Mercier
Genetic screens have been crucial for deciphering many important biological processes, including meiosis. In Arabidopsis thaliana , previous forward screens have likely identified almost all the meiotic genes that when mutated lead to a pronounced decrease in fertility. However, the increasing number of genes identified in reverse genetics studies that play crucial roles in meiosis, but do not exhibit strong phenotypes when mutated, suggests that there are still many genes with meiotic function waiting to be discovered...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30280366/gasdermin-family-a-promising-therapeutic-target-for-stroke
#14
REVIEW
Sheng Chen, Shuhao Mei, Yujie Luo, Hemmings Wu, Jianmin Zhang, Junming Zhu
Stroke is one of the leading causes of death worldwide and therapies are limited. According to the mechanisms underlying stroke, direct cell demise, destruction of organelles, blood-brain barrier disruption, neuroinflammation are potential therapeutic targets. Gasdermin (GSDM) family is a series of recently discovered proteins, which acts as the executor of pyroptosis and protagonist of membrane pore formation. It can be cleaved by inflammatory caspases that are activated by multi-protein complexes, named as inflammasomes, and divided into two domains...
October 3, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/30278046/multimodal-mri-suggests-that-male-homosexuality-may-be-linked-to-cerebral-midline-structures
#15
Amirhossein Manzouri, Ivanka Savic
The neurobiology of sexual preference is often discussed in terms of cerebral sex dimorphism. Yet, our knowledge about possible cerebral differences between homosexual men (HoM), heterosexual men (HeM) and heterosexual women (HeW) are extremely limited. In the present MRI study, we addressed this issue investigating measures of cerebral anatomy and function, which were previously reported to show sex difference. Specifically, we asked whether there were any signs of sex atypical cerebral dimorphism among HoM, if these were widely distributed (providing substrate for more general 'female' behavioral characteristics among HoM), or restricted to networks involved in self-referential sexual arousal...
2018: PloS One
https://www.readbyqxmd.com/read/30270450/surgical-repair-of-bilateral-coronary-artery-fistulae-and-a-left-main-coronary-artery-aneurysm-following-a-failed-percutaneous-embolization
#16
Umar Rashid, Afnan Tariq, Alvaro Dominguez, Chad Kliger, Jonathan Hemli, Derek Brinster
No abstract text is available yet for this article.
September 30, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/30269631/identifying-core-curricular-components-for-behavioral-health-training-in-internal-medicine-residency-qualitative-interviews-with-residents-faculty-and-behavioral-health-clinicians
#17
Patrick Hemming, Jessica A Revels, Anh N Tran, Lawrence H Greenblatt, Karen E Steinhauser
Objective Behavioral health services frequently delivered by primary care providers include care for mental health and substance abuse disorders and assistance with behavioral risk factor reduction. Internal medicine residencies in the United States lack formal expectations regarding training in behavioral health for residents. This qualitative study aimed to determine learners' and teachers' perceptions about appropriate behavioral health curricular components for internal medicine residents. Method Focus groups and interviews were conducted with the following individuals from the Duke Outpatient Clinic: residents with continuity practice (n = 27), advanced practice providers (n = 2), internal medicine attending physicians (n = 4), internal medicine/psychiatry attending physicians (n = 2), and behavioral health clinicians (n = 4)...
September 30, 2018: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/30261933/developing-a-framework-for-the-ethical-design-and-conduct-of-pragmatic-trials-in-healthcare-a-mixed-methods-research-protocol
#18
Monica Taljaard, Charles Weijer, Jeremy M Grimshaw, Adnan Ali, Jamie C Brehaut, Marion K Campbell, Kelly Carroll, Sarah Edwards, Sandra Eldridge, Christopher B Forrest, Bruno Giraudeau, Cory E Goldstein, Ian D Graham, Karla Hemming, Spencer Phillips Hey, Austin R Horn, Vipul Jairath, Terry P Klassen, Alex John London, Susan Marlin, John C Marshall, Lauralyn McIntyre, Joanne E McKenzie, Stuart G Nicholls, P Alison Paprica, Merrick Zwarenstein, Dean A Fergusson
BACKGROUND: There is a widely recognized need for more pragmatic trials that evaluate interventions in real-world settings to inform decision-making by patients, providers, and health system leaders. Increasing availability of electronic health records, centralized research ethics review, and novel trial designs, combined with support and resources from governments worldwide for patient-centered research, have created an unprecedented opportunity to advance the conduct of pragmatic trials, which can ultimately improve patient health and health system outcomes...
September 27, 2018: Trials
https://www.readbyqxmd.com/read/30253795/a-novel-method-of-non-clinical-dispatch-is-associated-with-a-higher-rate-of-critical-helicopter-emergency-medical-service-intervention
#19
Scott Munro, Mark Joy, Richard de Coverly, Mark Salmon, Julia Williams, Richard M Lyon
BACKGROUND: Helicopter Emergency Medical Services (HEMS) are a scarce resource that can provide advanced emergency medical care to unwell or injured patients. Accurate tasking of HEMS is required to incidents where advanced pre-hospital clinical care is needed. We sought to evaluate any association between non-clinically trained dispatchers, following a bespoke algorithm, compared with HEMS paramedic dispatchers with respect to incidents requiring a critical HEMS intervention. METHODS: Retrospective analysis of prospectively collected data from two 12-month periods was performed (Period one: 1st April 2014 - 1st April 2015; Period two: 1st April 2016 - 1st April 2017)...
September 25, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/30252913/improved-glycemic-control-with-minimal-systemic-metformin-exposure-effects-of-metformin-delayed-release-metformin-dr-targeting-the-lower-bowel-over-16-weeks-in-a-randomized-trial-in-subjects-with-type-2-diabetes
#20
Robert R Henry, Juan P Frias, Brandon Walsh, Sharon Skare, John Hemming, Colleen Burns, Thomas A Bicsak, Alain Baron, Mark Fineman
OBJECTIVE: Metformin use is restricted in patients with renal impairment due to potential excess systemic accumulation. This study evaluated the glycemic effects and safety of metformin delayed-release (Metformin DR), which targets metformin delivery to the ileum to leverage its gut-based mechanisms of action while minimizing systemic exposure. RESEARCH DESIGNS AND METHODS: Participants (T2DM [HbA1c 7-10.5%], eGFR ≥60 mL/min/1.73m2, not taking metformin for ≥2 months) were randomized to QD placebo (PBO); QD Metformin DR 600, 900, 1200, or 1500 mg; or to single-blind BID Metformin immediate-release (IR) 1000 mg...
2018: PloS One
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