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Fredrik Åberg, Helena Isoniemi, Eero Pukkala, Hannu Jalanko, Allan Rasmussen, Hans H Storm, Nicolai Schultz, William Bennet, Nils Ekvall, Bo-Göran Ericzon, Silvia Malenicka, Steinar Tretli, Pål-Dag Line, Kirsten Muri Boberg, Anniken Østensen, Tom Hemming Karlsen, Arno Nordin
Cancer after liver transplantation (LT) constitutes a threat also for young recipients, but cancer risk factors are usually absent in children and large studies on cancer risk profile in young LT recipients are scarce. Data of patients younger than 30 years who underwent LT 1982-2013 in the Nordic countries was linked with respective national cancer registries to calculate standardized incidence ratios (SIR). Thirty-seven cancer cases were observed in 923 patients with 7846 person-years of follow-up. The SIR for all cancer types, compared to matched general population, was 9...
August 18, 2018: Liver Transplantation
Nirav C Patel, Jonathan M Hemli, Michael C Kim, Karthik Seetharam, Luigi Pirelli, Derek R Brinster, S Jacob Scheinerman, Varinder P Singh
OBJECTIVE: We sought to evaluate midterm survival data and resource use for patients who received hybrid coronary revascularization for 2-vessel coronary disease (robotic-assisted left internal thoracic artery graft to left anterior descending coronary artery (minimally invasive direct coronary artery bypass), coupled with a stent to the circumflex or right coronary artery), compared with a concurrent cohort who had traditional coronary artery bypass grafting. METHODS: A comprehensive retrospective review was undertaken of our prospectively collected database from January 2009 to December 2016...
April 30, 2018: Journal of Thoracic and Cardiovascular Surgery
Julian Thompson, Marius Rehn, Stephen J M Sollid
BACKGROUND: Helicopter EMS (HEMS) teams may perform a variety of clinical, managerial and transport functions during major incident management. Despite national and international variations in HEMS systems, the rapid delivery of HEMS personnel with advanced skills in major incident management and clinical scene leadership has been crucial to the delivery of an effective medical response at previous incidents. This document outlines the Best Practice Advice of the European HEMS and Air Ambulance Committee (EHAC) Medical Working Group on how HEMS and Pre Hospital Critical Care teams may maximise the positive impact of their resources in the event of Major Incidents...
August 15, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Guido Carpino, Vincenzo Cardinale, Trine Folseraas, Diletta Overi, Krzysztof Grzyb, Daniele Costantini, Pasquale Bartolomeo Berloco, Sabina Di Matteo, Tom Hemming Karlsen, Domenico Alvaro, Eugenio Gaudio
Primary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy frequently complicated by cholangiocarcinoma (CCA). Massive proliferation of biliary tree stem/progenitor cells (BTSCs), expansion of peribiliary glands (PBGs), and dysplasia were observed in PSC. The aims of the present study were to evaluate the involvement of PBGs and BTSCs in CCA which emerged in PSC patients. Specimens from normal liver (N=5), PSC (N=20), and PSC-associated CCA (N=20) were included. Samples were processed for histology, immunohistochemistry and immunofluorescence...
August 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
M L Hemming, M C Heinrich, S Bauer, S George
Gastrointestinal stromal tumor (GIST) is the most common soft tissue sarcoma of the gastrointestinal tract and, in the vast majority of cases, is characterized by activating mutations in KIT or, less commonly, PDGFRA. Mutations in these type III receptor tyrosine kinases (RTKs) account for over 85% of GIST cases, and the majority of KIT primary mutations respond to treatment with the tyrosine kinase inhibitor (TKI) imatinib. However, drug resistance develops over time, most commonly due to secondary kinase mutations...
August 8, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Guey-Horng Wang, Yi-Min Lin, Jong-Tar Kuo, Chia-Pei Lin, Chin-Feng Chang, Min-Chi Hsieh, Chiu-Yu Cheng, Ying-Chien Chung
Asparagus cochinchinensis root (ACR) is used in traditional Chinese medicine. In this study, ACR was first extracted with 25% ethyl acetate (EA) and then fermented by Aspergillus oryzae to enhance its antioxidant activity and evaluate its potential antityrosinase activity. The physiological activity and cytotoxicity of A. oryzae-fermented ACR extract, along with its antityrosinase activity and effects on melanogenic factor levels in human epidermal melanocytes (HEMs), were analyzed and compared with those of the unfermented extract...
August 7, 2018: Journal of Bioscience and Bioengineering
Anmol Gupta, Amit Sachdeva, Narender Mahajan, Aakriti Gupta, Neha Sareen, Ravindra Mohan Pandey, Lakshmy Ramakrishnan, Hem Chandra Sati, Brij Sharma, Neetu Sharma, Umesh Kapil
Introduction: Recently, an increasing trend in the prevalence of pediatric metabolic syndrome (PMS) among school-age children has been documented in different parts of India. There is lack of data on the prevalence of PMS and its associated risk factors among school-age children living in district Shimla, Himachal Pradesh. Hence, to fill in the gap in the existing knowledge, the present study was conducted. Methodology: A cross-sectional study was conducted during 2015-2016...
May 2018: Indian Journal of Endocrinology and Metabolism
Yao Pan, Zeyuan Deng, Shi-Lian Zheng, Xuan Chen, Bing Zhang, Hongyan Li
The hydrophilic extracts of mulberry (HEM) and blueberry (HEB), lipophilic extracts of mango (LEM) and watermelon (LEW) were mixed in different ratios to assess the antioxidant interactions by chemical (DPPH and ABTS assay) and H9c2 cell-based models. There were both synergistic and antagonistic antioxidant interactions among daily fruits. Some groups with combinational extracts showed stronger synergistic antioxidant effects than the individual groups and others (HEM-LEW: F1/10, LEW-LEM: F5/10, HEB-LEM: F3/10) showed antagonistic effects than the individual groups based on the indicators (the values of DPPH, ABTS, MTT; the expression of SOD, GSH-Px, CAT, MDA; the release of LDH and the quantification of CAA)...
August 7, 2018: Journal of Agricultural and Food Chemistry
Pilar Esteve, Inmaculada Crespo, Polynikis Kaimakis, Africa Sandonís, Paola Bovolenta
The mammalian dorsal telencephalic neuroepithelium develops-from medial to lateral-into the choroid plaque, cortical hem, hippocampal primordium and isocortex under the influence of Bmp, Wnt and Notch signaling. Correct telencephalic development requires a tight coordination of the extent/duration of these signals, but the identification of possible molecular coordinators is still limited. Here, we postulated that Secreted Frizzled Related Protein 1 (Sfrp1), a multifunctional regulator of Bmp, Wnt and Notch signaling strongly expressed during early telencephalic development, may represent 1 of such molecules...
February 27, 2018: Cerebral Cortex
Buba Manjang, Karla Hemming, Chris Bradley, Jeroen Ensink, James T Martin, Jama Sowe, Abdou Jarju, Sandy Cairncross, Semira Manaseki-Holland
OBJECTIVE: Contamination of weaning food leads to diarrhoea in children under 5 years. Public health interventions to improve practices in low-income and middle-income countries are rare and often not evaluated using a randomised method. We describe an intervention implementation and provide baseline data for such a trial. DESIGN: Clustered randomised controlled trial. SETTING: Rural Gambia. PARTICIPANTS: 15 villages/clusters each with 20 randomly selected mothers with children aged 6-24 months per arm...
August 5, 2018: BMJ Open
Mansor Fazliana, Ahmad Zamri Liyana, Azahadi Omar, Rashidah Ambak, Noor Safiza Mohamad Nor, Ummi Kalthom Shamsudin, Narul Aida Salleh, Tahir Aris
BACKGROUND: Obesity is related to the increased incidence of hypertension and in healthy individuals, blood pressure changes with age and body mass. The aims of this paper were to evaluate the effectiveness of the weight loss intervention on body composition and blood pressure, and to evaluate the relationship between these factors among housewives in the MyBFF@home study. METHODS: MyBFF@home intervention was a quasi-experimental study which involved 328 overweight and obese housewives aged 18-59 years old (Control group: 159, Intervention group: 169)...
July 19, 2018: BMC Women's Health
Federico Landriel, Santiago Hem, Eduardo Vecchi, Claudio Yampolsky
Intradural extramedullary spinal tumors were historically managed through traditional midline approaches. Although conventional laminectomy or laminoplasty provides a wide tumor and spinal cord exposure, they may cause prolonged postoperative neck pain and late kyphosis deformity. Minimally invasive ipsilateral hemilaminectomy preserves midline structures, reduces the paraspinal muscle disruption, and could avoid postoperative kyphosis deformity. A safe tumor resection through this approach could be complicated in large sized or anteromedullary located lesions...
July 27, 2018: Operative Neurosurgery (Hagerstown, Md.)
Natalie Fisher, Michael G Edwards, Ryan Hemming, Steven M Allin, John D Wallis, Philip C Bulman Page, Michael J Mckenzie, Stefanie M Jones, Mark R J Elsegood, John King-Underwood, Alan Richardson
Autotaxin is an extracellular phospholipase D that catalyzes the hydrolysis of lysophosphatidyl choline (LPC) to generate the bioactive lipid lysophosphatidic acid (LPA). Autotaxin has been implicated in many pathological processes relevant to cancer. Intraperitoneal administration of an autotaxin inhibitor may benefit patients with ovarian cancer; however, low molecular mass compounds are known to be rapidly cleared from the peritoneal cavity. Icodextrin is a polymer that is already in clinical use because it is slowly eliminated from the peritoneal cavity...
August 15, 2018: Journal of Medicinal Chemistry
Abby K Scurfield
Signaling transduction pathways are now known to be foundational mechanisms for a wide variety of biological function. Nobel laureate Paul Greengard dedicated his early career to the exploration of how these molecular cascades are triggered by neurotransmitters, hence applying a general phenomenon to the nervous system. A review by Hemmings, Nairn, McGuinness, Huganir, and Greengard published in the FASEB journal in 1989 identifies three different effects of protein phosphorylation, namely vesicle release, modulation of receptor sensitivity, and initiation of positive or negative feedback systems...
2018: Journal of Undergraduate Neuroscience Education: JUNE: a Publication of FUN, Faculty for Undergraduate Neuroscience
Tania Mendonca, Tim R Birkhead, Ashley J Cadby, Wolfgang Forstmeier, Nicola Hemmings
The sperm mid-piece has traditionally been considered to be the engine that powers sperm. Larger mid-pieces have therefore been assumed to provide greater energetic capacity. However, in the zebra finch Taeniopygia guttata , a recent study showed a surprising negative relationship between mid-piece length and sperm energy content. Using a multi-dimensional approach to study mid-piece structure, we tested whether this unexpected relationship can be explained by a trade-off between mid-piece length and mid-piece thickness and/or cristae density inside the mitochondrial helix...
July 25, 2018: Proceedings. Biological Sciences
Brett A Faine, Sanjana Dayal, Rahul Kumar, Steven R Lentz, Enrique C Leira
INTRODUCTION: Rural and critical access hospitals rely on the "drip and ship" practice using helicopter emergency medical services (HEMS). But those helicopter flights are an unusual environment with physical factors such as vibration and accelerations that could potentially affect the stability, and pharmacological properties of IV rtPA, an issue that has not been previously addressed. MATERIALS AND METHODS: This was a prospective cohort study of consecutive acute ischemic stroke patients receiving IV rtPA through a Comprehensive Stroke Center from November 2015 to February 2017 to measure the effects of HEMS on the integrity and activity of rtPA by collecting residual medication left in the vial...
July 20, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Margherita Raccuglia, Christian Heyde, Alex Lloyd, Simon Hodder, George Havenith
PURPOSE: Moisture accumulation in clothing affects human performance and productivity through its impact on thermal balance and various aspects of discomfort. Building on our laboratory's work on mapping sweat production across the body, this study aimed to obtain detailed spatial and temporal maps showing how this sweat migrates into a single clothing layer (T-shirt) during physical exercise. METHOD: Eight male participants performed running exercise in a warm environment...
July 19, 2018: European Journal of Applied Physiology
Liba Sheeran, Rebecca Hemming, Robert van Deursen, Valerie Sparkes
This study determined differences in spinal-pelvic kinematics sitting on (i) mat (ii) block and (iii) novel 10º forward inclined wedge (ButtaflyTM ) in a same-subject repeated measures cross-over design in 60 healthy individuals (34 females). Repeated measures ANOVA revealed statistically significant differences between sitting conditions and lumbar and pelvic sagittal angles. Both, the inclined wedge and the block seating aids reduced overall flexion, but the inclined wedge had a greater influence in the lumbar region whilst the block induced the greatest change in the pelvis...
2018: Cogent engineering
Federico Landriel, Santiago Hem, Claudio Yampolsky
Neurogenic claudication is a common symptom of lumbar spinal stenosis; its pathophysiology is thought to be ischemia of the nerve roots secondary to compression from surrounding structures. The stenosis of the lateral recesses and neuroforamen can cause these symptoms and its surgical treatment is decompression. The placement of interbody cages that restore the disc space height may indirectly decompress the neuroforamen and alleviate the nerve impingement symptoms. In case of concomitant low-grade spondylolisthesis, interbody devices might also reduce the slippage...
July 17, 2018: Operative Neurosurgery (Hagerstown, Md.)
V M Chernov, O A Chernova, A A Mouzykantov, L V Lopukhov, M V Trushin
Inflammation and the ways for its regulation: The development of an effective system for the treatment of inflammatory diseases requires comprehensive studies of the cellular signaling molecular networks comprising responses to various stressors, including pathogenic and non-pathogenic microorganisms. Significant attention on fundamental and applied research has recently focused on inducers of hemе oxygenase-1 (HO-1) and inhibitors of the expression of this enzyme, which regulates expression of this and other cytoprotective molecules and modulation of inflammation...
July 16, 2018: Current Pharmaceutical Design
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