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https://www.readbyqxmd.com/read/30279622/short-term-replacement-of-starch-with-isomaltulose-enhances-both-insulin-dependent-and-independent-glucose-uptake-in-rat-skeletal-muscle
#1
Keiichi Koshinaka, Rie Ando, Akiko Sato
Dietary intervention for preventing postprandial increases in glucose level by replacing high-glycemic index (GI) carbohydrates with lower-GI carbohydrate has been proposed as a strategy for treating insulin-resistant metabolic disorders such as type II diabetes. In this study, we examined the effect of short-term replacement of starch with a low-GI disaccharide, isomaltulose, on insulin action in skeletal muscle. Male Wistar rats were fed isomaltulose for 12 h during their dark cycle. In isolated epitrochlearis muscle, insulin-induced glucose uptake was greater in tissue from rats treated with isomaltulose than from those treated with starch...
September 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/30252633/association-of-serum-vitamin-d-concentration-with-clinical-symptoms-and-quality-of-life-in-patients-with-irritable-bowel-syndrome
#2
Amir Abbasnezhad, Reza Amani, Amin Hasanvand, Esmaeil Yousefi Rad, Meysam Alipour, Somayeh Saboori, Razieh Choghakhori
OBJECTIVE: A high prevalence of vitamin D deficiency (VDD) in gastrointestinal (GI) disorders and the role of vitamin D in the function of the gut have been shown previously. Therefore, we aimed to evaluated the VDD and the possible association of the GI symptoms severity and quality of life (QoL) score with the serum levels of vitamin D in irritable bowel syndrome (IBS). METHODS: A total of 90 patients with IBS based on Rome III criteria enrolled in the study from the tertiary referral university hospital...
September 25, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/30196529/determinants-of-binge-eating-disorder-among-normal-weight-and-overweight-female-college-students-in-korea
#3
Youl-Ri Kim, Bo In Hwang, Gi Young Lee, Kyung Hee Kim, Mirihae Kim, Kwang Kee Kim, Janet Treasure
PURPOSE: The aim of the present study was to describe the clinical features of binge eating disorder (BED) in normal weight and overweight undergraduate Korean women. METHODS: 117 overweight (BMI ≥ 25 kg/m2 ) and 346 normal weight (18 kg/m2  ≤ BMI < 25 kg/m2 ) undergraduate Korean women completed questionnaires to assess for BED. Their emotional eating behaviors, binge eating-related behaviors, a spectrum of compulsive behaviors such as substance abuse and obsessive-compulsive disorder, and psychological profiles were evaluated through personal interviews and questionnaires...
September 8, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/30160516/reduced-symptoms-of-post-traumatic-stress-disorder-and-irritable-bowel-syndrome-following-mindfulness-based-stress-reduction-among-veterans
#4
Kaitlin Harding, Tracy Simpson, David J Kearney
OBJECTIVES: Post-traumatic stress disorder (PTSD) and irritable bowel syndrome (IBS) are highly comorbid conditions associated with reduced health-related quality of life. Comorbid prevalence is especially high among veterans, ranging from 23% to 51%, but there is limited research on integrative treatments. DESIGN: To improve treatment of comorbid PTSD and IBS, this study examined the impact of mindfulness-based stress reduction (MBSR) on symptom reduction and mindfulness skill building among veterans with this comorbidity...
August 30, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/30132170/recent-advances-in-pharmacological-research-on-the-management-of-irritable-bowel-syndrome
#5
REVIEW
Yoonjin Nam, Young Sil Min, Uy Dong Sohn
Irritable bowel syndrome (IBS), a common gastrointestinal (GI) disorder, is associated with various factors, including lifestyle, infection, stress, intestinal flora, and related diseases. The pharmacotherapeutic stimulation of receptors and downstream signaling pathways is effective in reducing IBS symptoms; however, it is still associated with adverse effects. Various receptors related to GI motility and visceral hypersensitivity should be considered to enhance the benefit/risk ratio of IBS treatments. This review discusses recent pharmacological advances in IBS management...
October 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30114898/the-effect-of-trimebutine-on-the-overlap-syndrome-model-of-guinea-pigs
#6
Zahid Hussain, Da Hyun Jung, Young Ju Lee, Hyojin Park
Background/Aims: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) disorders and these patients frequently overlap. Trimebutine has been known to be effective in controlling FD co-existing diarrhea-dominant IBS, however its effect on overlap syndrome (OS) patients has not been reported. Therefore, we investigated the effect of trimebutine on the model of OS in guinea pigs. Methods: Male guinea pigs were used to evaluate the effects of trimebutine in corticotropin-releasing factor (CRF) induced OS model...
August 16, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30109908/effect-of-a-prebiotic-galactooligosaccharide-mixture-b-gos%C3%A2-on-gastrointestinal-symptoms-in-adults-selected-from-a-general-population-who-suffer-with-bloating-abdominal-pain-or-flatulence
#7
Jelena Vulevic, George Tzortzis, Aleksandra Juric, Glenn R Gibson
BACKGROUND: Prebiotics exert beneficial effects upon gastrointestinal (GI) environment, but this is not always accompanied with a positive effect on GI symptoms. B-GOS® is a prebiotic with high selectivity toward bifidobacteria and a variety of other beneficial effects in humans. Here, we investigated its effect on GI symptoms in adults who suffer with bloating, abdominal pain, and flatulence. METHODS: In a double-blind, placebo-controlled, crossover study, 83 subjects from the general population who presented with GI symptoms during screening period and had a predicted probability of functional bowel disorder of more than 75% were randomized to receive either a placebo or the B-GOS® treatment (2...
November 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/30108477/diet-can-impact-microbiota-composition-in-children-with-autism-spectrum-disorder
#8
Kirsten Berding, Sharon M Donovan
Diet is one of the most influential environmental factors in determining the composition of the gastrointestinal microbiota. Microbial dysbiosis in children with Autism Spectrum Disorder (ASD) and the impact of some bacterial taxa on symptoms of ASD has been recognized. Children with ASD are often described as picky eaters with low intake of fiber-rich foods, including fruits and vegetables. However, the impact of diet on the microbiota composition in children with ASD is largely unknown. Herein, fecal samples, 3 day food diaries and the Youth and Adolescence Food Frequency questionnaire (YAQ) were collected from children with ASD (ASD; n = 26) and unaffected controls (CONT; n = 32)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/30094945/prevalence-of-functional-gi-disorders-among-pediatric-patients-with-persistent-asthma
#9
Ruben J Colman, Neal Bryan S Rosario, Analydia Gutierrez Bonilla, Gabriela Benavidez Alvarez, Joel Benavidez Alvarez, Vincent P Uy, Paulo R Pina, David H Rubin
OBJECTIVE: Functional gastrointestinal (GI) disorders (FGIDs), such as irritable bowel syndrome, functional abdominal pain and dyspepsia, are common causes of chronic GI symptoms in children. Prior studies found high comorbidity of FGID and asthma. This study aimed to assess the prevalence and comorbidities of FGID among pediatric patients with asthma at a university-affiliated urban community hospital. METHODS: This prospective, cross-sectional study assessed FGID prevalence, asthma control and symptoms of anxiety among pediatric patients with persistent asthma...
August 9, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/30094167/a-functional-limitation-to-the-lower-limbs-affects-the-neural-bases-of-motor-imagery-of-gait
#10
Lucia Maria Sacheli, Laura Zapparoli, Matteo Preti, Carlo De Santis, Catia Pelosi, Nicola Ursino, Alberto Zerbi, Elena Stucovitz, Giuseppe Banfi, Eraldo Paulesu
Studies on athletes or neurological patients with motor disorders have shown a close link between motor experience and motor imagery skills. Here we evaluated whether a functional limitation due to a musculoskeletal disorder has an impact on the ability to mentally rehearse the motor patterns of walking, an overlearned and highly automatic behaviour. We assessed the behavioural performance (measured through mental chronometry tasks) and the neural signatures of motor imagery of gait in patients with chronic knee arthrosis and in age-matched, healthy controls...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/30071894/a-prebiotic-intervention-study-in-children-with-autism-spectrum-disorders-asds
#11
Roberta Grimaldi, Glenn R Gibson, Jelena Vulevic, Natasa Giallourou, Josué L Castro-Mejía, Lars H Hansen, E Leigh Gibson, Dennis S Nielsen, Adele Costabile
BACKGROUND: Different dietary approaches, such as gluten and casein free diets, or the use of probiotics and prebiotics have been suggested in autistic spectrum disorders in order to reduce gastrointestinal (GI) disturbances. GI symptoms are of particular interest in this population due to prevalence and correlation with the severity of behavioural traits. Nowadays, there is lack of strong evidence about the effect of dietary interventions on these problems, particularly prebiotics. Therefore, we assessed the impact of exclusion diets and a 6-week Bimuno® galactooligosaccharide (B-GOS®) prebiotic intervention in 30 autistic children...
August 2, 2018: Microbiome
https://www.readbyqxmd.com/read/30067118/black-radish-raphanus-sativus-l-var-niger-extract-mediates-its-hepatoprotective-effect-on-carbon-tetrachloride-induced-hepatic-injury-by-attenuating-oxidative-stress
#12
Meejung Ahn, Jeongtae Kim, Seunghyun Hong, Jungeun Kim, Hana Ko, Nam-Ho Lee, Gi-Ok Kim, Taekyun Shin
Nonalcoholic fatty liver disease is a serious liver disorder associated with oxidative stress. Black radish (Raphanus sativus L. var. niger) extract (BRE) can lower the risk of this disease. The hepatoprotective effect of BRE containing 3-(E)-(methylthio)methylene-2-pyrrolidinethione was evaluated in human hepatocyte carcinoma (HepG2) cells and in rat livers with carbon tetrachloride (CCl4 )-induced hepatic injury. BRE was administered at 125, 250, 500, and 1000 μg/mL to the oleic acid-induced HepG2 cells...
September 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/30066292/cardiovascular-and-gastrointestinal-safety-of-selective-cyclooxygenase-2-inhibitors-a-case-non-case-study
#13
Luis Hermenegildo Martin Arias, Antonio Martin Gonzalez, Rosario Sanz Fadrique, Esther Salgueiro, Maria Sainz
Background Coxibs cardiovascular (CV) safety continues being a current issue after rofecoxib worldwide withdrawal in 2004. Objective To evaluate the cardiovascular and gastrointestinal (GI) risk of coxibs through case/non-case study. Setting The Spanish Pharmacovigilance System for Human Use Drugs (FEDRA) and the Uppsala Monitoring Centre (VigiBase) databases. Method We identified adverse drug reactions (ADRs) cases reported under the MedDRA system organ classes of "cardiac disorders", "vascular disorders", "nervous system disorder" and "gastrointestinal disorders"...
August 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30056562/improved-hemoglobin-response-with-ferric-carboxymaltose-in-patients-with-gastrointestinal-related-iron-deficiency-anemia-versus-oral-iron
#14
Gary R Lichtenstein, Jane E Onken
AIMS: To compare the efficacy and safety of intravenous (IV) ferric carboxymaltose (FCM) versus oral iron and other IV iron therapies in patients with iron-deficiency anemia (IDA) resulting from gastrointestinal (GI) disorders. METHODS: A pooled analysis of four prospective, randomized, active-controlled trials in patients with IDA was performed. Efficacy measures included change from baseline in hemoglobin (Hb), ferritin, and transferrin saturation (TSAT) and correlations of baseline Hb, ferritin, and TSAT to change in Hb...
July 28, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30034512/triphala-current-applications-and-new-perspectives-on-the-treatment-of-functional-gastrointestinal-disorders
#15
REVIEW
Aleksandra Tarasiuk, Paula Mosińska, Jakub Fichna
Background: Ayurvedic medicine is based on natural healing methods that use herbal medicine to cleanse the body of toxins and to attain physical and mental regeneration. Triphala (TLP) is one of the most important ayurvedic supplements and is believed to have a beneficial effect on the entire gastrointestinal (GI) tract. Purpose: We aim to summarize available literature focused on the components of TLP ( Terminalia chebula , Terminalia bellerica and Phyllanthus emblica ) and discusse their effectiveness and therapeutic value for improving lower GI symptoms in functional GI disorders, particularly irritable bowel syndrome (IBS)...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29795991/gastrointestinal-lesions-in-african-american-patients-with-iron-deficiency-anemia
#16
Hassan Brim, Anahita Shahnazi, Mehdi Nouraie, Dilhana Badurdeen, Adeyinka O Laiyemo, Tahmineh Haidary, Ali Afsari, Hassan Ashktorab
Background: Iron deficiency anemia (IDA) is a frequent disorder that is associated with many serious diseases. However, the findings of an evaluation of IDA-associated gastrointestinal disorders are lacking among African American patients. Aim: To determine the most prevalent gastrointestinal lesions among African American patients with IDA especially in young men. Methods: We reviewed medical records (n = 422) of patients referred for evaluation of IDA from 2008 to 2012...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/29707075/upper-and-lower-gastrointestinal-endoscopic-findings-in-hiv-infected-patients-in-the-era-of-highly-active-antiretroviral-therapy
#17
Russell Parvin, Sindhura Kolli, Jamil Shah, Manan Jhaveri, Madhavi Reddy
Background: Endoscopic evaluation with biopsies are instrumental in the diagnosis and management of gastrointestinal (GI) disorders in the setting of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS), especially in the era of highly active antiretroviral therapy (HAART). Methods: A retrospective chart review of 304 HIV-positive and 199 HIV-negative patients who had undergone upper and/or lower endoscopy in an urban community hospital from the years 2012 - 2017 was performed...
April 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29694969/clinical-features-of-hereditary-angioedema-in-korean-patients-a-nationwide-multicenter-study
#18
MULTICENTER STUDY
Jae-Woo Jung, Dong In Suh, Hye Jung Park, Sujeong Kim, Hyouk Soo Kwon, Min Suk Yang, Chan Sun Park, Joo-Hee Kim, Sae-Hoon Kim, Yong Won Lee, Gyu Young Hur, Young-Min Ye, Yong Eun Kwon, Hye-Kyung Park, Cheol Woo Kim, Young-Il Koh, Jung Wong Park, Jong-Myung Lee, Kyung-Up Min, Paige Wickner, Hye-Ryun Kang
BACKGROUND: Hereditary angioedema (HAE) is a genetically heterogeneous autosomal dominant disorder characterized by recurrent episodes of nonpruritic, nonpitting edema increasing after puberty. It can be fatal due to laryngeal or gastrointestinal (GI) involvement with varied and changing frequency of mortality according to studies published from the Western countries. Epidemiological and clinical data of HAE in Asian countries are sparse. We sought to examine the clinical characteristics of HAE patients in Korea...
2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29605984/connecting-our-gut-feeling-and-how-our-gut-feels-the-role-of-well-being-attributes-in-irritable-bowel-syndrome
#19
Ashkan Farhadi, Dwaine Banton, Laurie Keefer
Background/Aims: There is a close relationship between the mind and gut in the pathogenesis of functional bowel disorders. Common psychological disturbances such as depression and anxiety are not uncommon in those with irritable bowel syndrome (IBS). There is little research investigating the role of positive psychology and gastrointestinal (GI) conditions. In this pilot study we investigated the well-being attributes in those with and without IBS. Methods: We used an anonymous online survey and recruited 416 study subjects using social media as the main method of recruitment...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29577672/cancer-risk-in-patients-with-alopecia-areata-a-nationwide-population-based-matched-cohort-study
#20
Chih-Chiang Chen, Yun-Ting Chang, Han-Nan Liu, Yi-Ju Chen
Alopecia areata (AA) is an organ-specific autoimmune disorder. Defective immune system related disorders are prone to increase the risk of cancer formation. However, the association among AA and variety of cancer types had never been studied. A nationwide population-based matched cohort study was conducted to evaluate the cancer risk in patients with AA. Records from Taiwan National Health Insurance Research Database were analyzed. Cases of AA from 1997 to 2013 and cancers registered in the catastrophic illness profile from the same time period were collected...
May 2018: Cancer Medicine
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