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https://www.readbyqxmd.com/read/30109908/effect-of-a-prebiotic-galactooligosaccharide-mixture-b-gos%C3%A2-on-gastrointestinal-symptoms-in-adults-selected-from-a-general-population-who-suffer-with-bloating-abdominal-pain-or-flatulence
#1
Jelena Vulevic, George Tzortzis, Aleksandra Juric, Glenn R Gibson
BACKGROUND: Prebiotics exert beneficial effects upon gastrointestinal (GI) environment, but this is not always accompanied with a positive effect on GI symptoms. B-GOS® is a prebiotic with high selectivity toward bifidobacteria and a variety of other beneficial effects in humans. Here, we investigated its effect on GI symptoms in adults who suffer with bloating, abdominal pain, and flatulence. METHODS: In a double-blind, placebo-controlled, crossover study, 83 subjects from the general population who presented with GI symptoms during screening period and had a predicted probability of functional bowel disorder of more than 75% were randomized to receive either a placebo or the B-GOS® treatment (2...
August 15, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/30108477/diet-can-impact-microbiota-composition-in-children-with-autism-spectrum-disorder
#2
Kirsten Berding, Sharon M Donovan
Diet is one of the most influential environmental factors in determining the composition of the gastrointestinal microbiota. Microbial dysbiosis in children with Autism Spectrum Disorder (ASD) and the impact of some bacterial taxa on symptoms of ASD has been recognized. Children with ASD are often described as picky eaters with low intake of fiber-rich foods, including fruits and vegetables. However, the impact of diet on the microbiota composition in children with ASD is largely unknown. Herein, fecal samples, 3 day food diaries and the Youth and Adolescence Food Frequency questionnaire (YAQ) were collected from children with ASD (ASD; n = 26) and unaffected controls (CONT; n = 32)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/30094945/functional-gi-disorders-are-prevalent-among-pediatric-patients-with-persistent-asthma
#3
Ruben J Colman, Neal Bryan S Rosario, Analydia Gutierrez Bonilla, Gabriela Benavidez Alvarez, Joel Benavidez Alvarez, Vincent P Uy, Paulo R Pina, David H Rubin
AIM: Functional gastrointestinal disorders (such as functional abdominal pain, irritable bowel syndrome and functional dyspepsia) are a common cause of chronic GI symptoms in children. Prior studies demonstrated a high comorbidity of functional GI disorders (FGIDs) among patients with asthma. However, data exploring specific disease characteristics within the US populations are scarce. This study aimed to assess the prevalence and comorbidities of FGIDs among pediatric asthma patients at a university-affiliated urban community hospital...
August 9, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/30094167/a-functional-limitation-to-the-lower-limbs-affects-the-neural-bases-of-motor-imagery-of-gait
#4
Lucia Maria Sacheli, Laura Zapparoli, Matteo Preti, Carlo De Santis, Catia Pelosi, Nicola Ursino, Alberto Zerbi, Elena Stucovitz, Giuseppe Banfi, Eraldo Paulesu
Studies on athletes or neurological patients with motor disorders have shown a close link between motor experience and motor imagery skills. Here we evaluated whether a functional limitation due to a musculoskeletal disorder has an impact on the ability to mentally rehearse the motor patterns of walking, an overlearned and highly automatic behaviour. We assessed the behavioural performance (measured through mental chronometry tasks) and the neural signatures of motor imagery of gait in patients with chronic knee arthrosis and in age-matched, healthy controls...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/30071894/a-prebiotic-intervention-study-in-children-with-autism-spectrum-disorders-asds
#5
Roberta Grimaldi, Glenn R Gibson, Jelena Vulevic, Natasa Giallourou, Josué L Castro-Mejía, Lars H Hansen, E Leigh Gibson, Dennis S Nielsen, Adele Costabile
BACKGROUND: Different dietary approaches, such as gluten and casein free diets, or the use of probiotics and prebiotics have been suggested in autistic spectrum disorders in order to reduce gastrointestinal (GI) disturbances. GI symptoms are of particular interest in this population due to prevalence and correlation with the severity of behavioural traits. Nowadays, there is lack of strong evidence about the effect of dietary interventions on these problems, particularly prebiotics. Therefore, we assessed the impact of exclusion diets and a 6-week Bimuno® galactooligosaccharide (B-GOS®) prebiotic intervention in 30 autistic children...
August 2, 2018: Microbiome
https://www.readbyqxmd.com/read/30067118/black-radish-raphanus-sativus-l-var-niger-extract-mediates-its-hepatoprotective-effect-on-carbon-tetrachloride-induced-hepatic-injury-by-attenuating-oxidative-stress
#6
Meejung Ahn, Jeongtae Kim, Seunghyun Hong, Jungeun Kim, Hana Ko, Nam-Ho Lee, Gi-Ok Kim, Taekyun Shin
Nonalcoholic fatty liver disease is a serious liver disorder associated with oxidative stress. Black radish (Raphanus sativus L. var. niger) extract (BRE) can lower the risk of this disease. The hepatoprotective effect of BRE containing 3-(E)-(methylthio)methylene-2-pyrrolidinethione was evaluated in human hepatocyte carcinoma (HepG2) cells and in rat livers with carbon tetrachloride (CCl4 )-induced hepatic injury. BRE was administered at 125, 250, 500, and 1000 μg/mL to the oleic acid-induced HepG2 cells...
August 1, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/30066292/cardiovascular-and-gastrointestinal-safety-of-selective-cyclooxygenase-2-inhibitors-a-case-non-case-study
#7
Luis Hermenegildo Martin Arias, Antonio Martin Gonzalez, Rosario Sanz Fadrique, Esther Salgueiro, Maria Sainz
Background Coxibs cardiovascular (CV) safety continues being a current issue after rofecoxib worldwide withdrawal in 2004. Objective To evaluate the cardiovascular and gastrointestinal (GI) risk of coxibs through case/non-case study. Setting The Spanish Pharmacovigilance System for Human Use Drugs (FEDRA) and the Uppsala Monitoring Centre (VigiBase) databases. Method We identified adverse drug reactions (ADRs) cases reported under the MedDRA system organ classes of "cardiac disorders", "vascular disorders", "nervous system disorder" and "gastrointestinal disorders"...
July 31, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/30056562/improved-hemoglobin-response-with-ferric-carboxymaltose-in-patients-with-gastrointestinal-related-iron-deficiency-anemia-versus-oral-iron
#8
Gary R Lichtenstein, Jane E Onken
AIMS: To compare the efficacy and safety of intravenous (IV) ferric carboxymaltose (FCM) versus oral iron and other IV iron therapies in patients with iron-deficiency anemia (IDA) resulting from gastrointestinal (GI) disorders. METHODS: A pooled analysis of four prospective, randomized, active-controlled trials in patients with IDA was performed. Efficacy measures included change from baseline in hemoglobin (Hb), ferritin, and transferrin saturation (TSAT) and correlations of baseline Hb, ferritin, and TSAT to change in Hb...
July 28, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30034512/triphala-current-applications-and-new-perspectives-on-the-treatment-of-functional-gastrointestinal-disorders
#9
REVIEW
Aleksandra Tarasiuk, Paula Mosińska, Jakub Fichna
Background: Ayurvedic medicine is based on natural healing methods that use herbal medicine to cleanse the body of toxins and to attain physical and mental regeneration. Triphala (TLP) is one of the most important ayurvedic supplements and is believed to have a beneficial effect on the entire gastrointestinal (GI) tract. Purpose: We aim to summarize available literature focused on the components of TLP ( Terminalia chebula , Terminalia bellerica and Phyllanthus emblica ) and discusse their effectiveness and therapeutic value for improving lower GI symptoms in functional GI disorders, particularly irritable bowel syndrome (IBS)...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29795991/gastrointestinal-lesions-in-african-american-patients-with-iron-deficiency-anemia
#10
Hassan Brim, Anahita Shahnazi, Mehdi Nouraie, Dilhana Badurdeen, Adeyinka O Laiyemo, Tahmineh Haidary, Ali Afsari, Hassan Ashktorab
Background: Iron deficiency anemia (IDA) is a frequent disorder that is associated with many serious diseases. However, the findings of an evaluation of IDA-associated gastrointestinal disorders are lacking among African American patients. Aim: To determine the most prevalent gastrointestinal lesions among African American patients with IDA especially in young men. Methods: We reviewed medical records (n = 422) of patients referred for evaluation of IDA from 2008 to 2012...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/29707075/upper-and-lower-gastrointestinal-endoscopic-findings-in-hiv-infected-patients-in-the-era-of-highly-active-antiretroviral-therapy
#11
Russell Parvin, Sindhura Kolli, Jamil Shah, Manan Jhaveri, Madhavi Reddy
Background: Endoscopic evaluation with biopsies are instrumental in the diagnosis and management of gastrointestinal (GI) disorders in the setting of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS), especially in the era of highly active antiretroviral therapy (HAART). Methods: A retrospective chart review of 304 HIV-positive and 199 HIV-negative patients who had undergone upper and/or lower endoscopy in an urban community hospital from the years 2012 - 2017 was performed...
April 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29694969/clinical-features-of-hereditary-angioedema-in-korean-patients-a-nationwide-multicenter-study
#12
MULTICENTER STUDY
Jae-Woo Jung, Dong In Suh, Hye Jung Park, Sujeong Kim, Hyouk Soo Kwon, Min Suk Yang, Chan Sun Park, Joo-Hee Kim, Sae-Hoon Kim, Yong Won Lee, Gyu Young Hur, Young-Min Ye, Yong Eun Kwon, Hye-Kyung Park, Cheol Woo Kim, Young-Il Koh, Jung Wong Park, Jong-Myung Lee, Kyung-Up Min, Paige Wickner, Hye-Ryun Kang
BACKGROUND: Hereditary angioedema (HAE) is a genetically heterogeneous autosomal dominant disorder characterized by recurrent episodes of nonpruritic, nonpitting edema increasing after puberty. It can be fatal due to laryngeal or gastrointestinal (GI) involvement with varied and changing frequency of mortality according to studies published from the Western countries. Epidemiological and clinical data of HAE in Asian countries are sparse. We sought to examine the clinical characteristics of HAE patients in Korea...
2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29605984/connecting-our-gut-feeling-and-how-our-gut-feels-the-role-of-well-being-attributes-in-irritable-bowel-syndrome
#13
Ashkan Farhadi, Dwaine Banton, Laurie Keefer
Background/Aims: There is a close relationship between the mind and gut in the pathogenesis of functional bowel disorders. Common psychological disturbances such as depression and anxiety are not uncommon in those with irritable bowel syndrome (IBS). There is little research investigating the role of positive psychology and gastrointestinal (GI) conditions. In this pilot study we investigated the well-being attributes in those with and without IBS. Methods: We used an anonymous online survey and recruited 416 study subjects using social media as the main method of recruitment...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29577672/cancer-risk-in-patients-with-alopecia-areata-a-nationwide-population-based-matched-cohort-study
#14
Chih-Chiang Chen, Yun-Ting Chang, Han-Nan Liu, Yi-Ju Chen
Alopecia areata (AA) is an organ-specific autoimmune disorder. Defective immune system related disorders are prone to increase the risk of cancer formation. However, the association among AA and variety of cancer types had never been studied. A nationwide population-based matched cohort study was conducted to evaluate the cancer risk in patients with AA. Records from Taiwan National Health Insurance Research Database were analyzed. Cases of AA from 1997 to 2013 and cancers registered in the catastrophic illness profile from the same time period were collected...
May 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29541439/network-specific-sex-differentiation-of-intrinsic-brain-function-in-males-with-autism
#15
Dorothea L Floris, Meng-Chuan Lai, Tanmay Nath, Michael P Milham, Adriana Di Martino
Background: The male predominance in the prevalence of autism spectrum disorder (ASD) has motivated research on sex differentiation in ASD. Multiple sources of evidence have suggested a neurophenotypic convergence of ASD-related characteristics and typical sex differences. Two existing, albeit competing, models provide predictions on such neurophenotypic convergence. These two models are testable with neuroimaging. Specifically, the Extreme Male Brain (EMB) model predicts that ASD is associated with enhanced brain maleness in both males and females with ASD (i...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29533398/identification-of-individuals-with-functional-dyspepsia-with-a-simple-minimally-invasive-test-a-single-center-cohort-study-of-the-oral-capsaicin-test
#16
Johann Hammer
OBJECTIVES: The diagnosis of functional dyspepsia (FD) is challenging due to the lack of reliable biological markers to support the diagnosis. We assessed the relevance of a previously validated simple test for chemical hypersensitivity in the setting of a gastrointestinal outpatient department. METHODS: A total of 224 outpatients who were referred for evaluation of gastrointestinal symptoms in the absence of alarm symptoms swallowed a capsule containing 0.75 mg capsaicin...
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29510215/factor-analysis-defines-distinct-upper-and-lower-gastrointestinal-symptom-groups-compatible-with-rome-iv-criteria-in-a-population-based-study
#17
Egbert Clevers, William E Whitehead, Olafur S Palsson, Ami D Sperber, Hans Törnblom, Lukas Van Oudenhove, Jan Tack, Magnus Simrén
BACKGROUND & AIMS: The Rome IV criteria define functional gastrointestinal (GI) disorders by specific combinations of symptoms. It is possible to empirically evaluate these symptom combinations by factor analysis (a statistical procedure that groups variables that correlate). However, this analysis has not been performed for the Rome IV criteria, and factor analyses based on the previous versions of the Rome criteria did not use population-based data. We therefore investigated symptom grouping by the Rome IV questionnaire using factor analysis of a population-based sample...
August 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29485007/pinpoint-localized-odynophagia-plo-as-a-specific-symptom-of-pill-induced-oesophagitis-pio-in-the-evaluation-of-acute-retrosternal-chest-pain
#18
Dhruvkumar Patel, Mukundkumar V Patel, Sanjay L Rajput, Kamal Sharma
INTRODUCTION: 36 out of 100 cases of retrosternal chest pains are due to oesophageal pathologies and pill-induced oesophagitis(PIO) is one of them. PIO can present as retrosternal chest pain associated with various gastrointestinal (GI) symptoms and require a high index of suspicion. PIO is a clinical diagnosis; and oesophagogastroscopy is required for confirmation of the diagnosis, to find out complications of PIO and to rule out other oesophageal disorders. Our aims of the present study were to study clinical profile, risk factors and endoscopic features of PIO...
February 26, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29483895/involvement-of-corticotropin-releasing-factor-and-receptors-in-immune-cells-in-irritable-bowel-syndrome
#19
REVIEW
Mahanand Chatoo, Yi Li, Zhiqiang Ma, John Coote, Jizeng Du, Xuequn Chen
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder defined by ROME IV criteria as pain in the lower abdominal region, which is associated with altered bowel habit or defecation. The underlying mechanism of IBS is not completely understood. IBS seems to be a product of interactions between various factors with genetics, dietary/intestinal microbiota, low-grade inflammation, and stress playing a key role in the pathogenesis of this disease. The crosstalk between the immune system and stress in IBS mechanism is increasingly recognized...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29394213/eosinophil-counts-in-the-small-intestine-and-colon-of-children-without-apparent-gastrointestinal-disease-a-meta-analysis
#20
Zoltán Kiss, Bálint Tél, Nelli Farkas, András Garami, Áron Vincze, Judit Bajor, Patrícia Sarlós, Katalin Márta, Adrienn Erős, Alexandra Mikó, Zsolt Szakács, Dániel Pécsi, Péter Mátrai, Péter Hegyi, Gábor Veres
The aim of the current study was to review the available data regarding eosinophil density in healthy tissue specimen originating from lower gastrointestinal segments to support suggested diagnostic cutoffs widely used in clinical practice. A systematic search was performed in 3 different databases. Calculations were made with Comprehensive MetaAnalysis software using random-effects model. Cell number measurements were pooled using the random-effects model and displayed on forest plots. Summary point estimations, 95% confidence intervals (CIs), and 95% prediction intervals (PIs) were calculated...
July 2018: Journal of Pediatric Gastroenterology and Nutrition
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