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https://www.readbyqxmd.com/read/30114898/the-effect-of-trimebutine-on-the-overlap-syndrome-model-of-guinea-pigs
#1
Zahid Hussain, Da Hyun Jung, Young Ju Lee, Hyojin Park
Background/Aims: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) disorders and these patients frequently overlap. Trimebutine has been known to be effective in controlling FD co-existing diarrhea-dominant IBS, however its effect on overlap syndrome (OS) patients has not been reported. Therefore, we investigated the effect of trimebutine on the model of OS in guinea pigs. Methods: Male guinea pigs were used to evaluate the effects of trimebutine in corticotropin-releasing factor (CRF) induced OS model...
August 16, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/30112312/prevalence-of-helicobacter-pylori-infection-in-upper-gastrointestinal-tract-disorders-dyspepsia-patients-visiting-outpatient-department-of-a-hospital-of-north-india
#2
Puneet Kumar Agarwal, Mayank Badkur, Richa Agarwal, Seema Patel
Background: Helicobacter pylori infection is a major health ailment in developing countries. The infection is related with high morbidity and mortality ranging from chronic gastritis to gastric malignancies. The prevalence of H. pylori infection greatly varies from country to country and region to region. The aim is to study the prevalence of H. pylori infection in upper gastrointestinal (GI) tract disorders (dyspepsia) patients. Methods: The study was carried out in an outpatient department, India...
May 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/30057791/oral-health-related-quality-of-life-in-patients-with-upper-gastrointestinal-and-hepatic-disorders-in-pakistan-validation-of-the-oral-health-impact-profile-14-in-the-urdu-language
#3
Ibrahim Warsi, Anjum Younus, Abdur Rasheed, Javeria Ahmed, Hafsa Mahida, Rimsha Hashmi, Ambrina Qureshi
Introduction: The Oral Health Impact Profile (OHIP-14) has been used extensively to measure the impact of oral disease on oral health-related quality of life (HRQoL) but has not been validated in the Urdu language or tested in gastroenterology. Aims: To validate the OHIP-14 for use in Pakistan and its ability to assess oral health in patients with upper gastrointestinal (GI) and hepatic disorders. Design: Multicentre, cross-sectional. Setting: Four major tertiary care hospitals...
2018: BDJ Open
https://www.readbyqxmd.com/read/30002206/multiple-intestinal-perforations-due-to-blister-pill-pack-ingestion
#4
Francesc Simo Alari, Israel Gutierrez
A 72-year-old woman with morbid obesity and history of psychosis attended the emergency room due to abdominal pain. CT scan revealed a mesenteric infiltration surrounding a thickened wall bowel agglomeration; inside, a dense 2 cm foreign body with no pneumoperitoneum or peritoneal effusion. Surgery revealed four contained bowel perforations due to a blister pill pack inside the ileum; consequently, a 30 cm bowel resection was performed. Ingestion was restarted on day 2, a superficial wound infection was evacuated on day 4 and the patient was discharged 6 days after surgery...
July 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29979404/etiological-aspects-of-intragastric-bezoars-and-its-associations-to-the-gastric-function-implications-a-case-report-and-a-literature-review
#5
REVIEW
Samiullah Khan, Iftikhar-Ahmad Khan, Kifayat Ullah, Saima Khan, Xuan Wang, Lan-Ping Zhu, Mujeeb Ur Rehman, Xin Chen, Bang-Mao Wang
RATIONALE: Intragastric bezoar is a stony mass found trapped in the stomach, though it can occur in other locations of the gastro-intestinal tract. The etiology of intragastric bezoar is multifactorial, includes certain risk factors and predisposing factors such as coexisting medical disorders, anatomic abnormalities, and gastric motility disorders, which contribute to the development of intragastric bezoar. PATIENT CONCERNS: In this report, we present a rare case of intragastric bezoar with epigastric pain after prolonged consumption of jujubes...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29786011/nontraumatic-subperiosteal-orbital-hemorrhage-following-upper-gastrointestinal-endoscopy
#6
Swaranjali S Gore, Neha Rathi, Amol Y Ganvir, Nayana A Potdar, Monisha K Apte, Trupti R Marathe, Akshay Gopinathan Nair, Chhaya A Shinde
Subperiosteal hemorrhages are typically the result of blunt orbital or facial trauma. Nontraumatic subperiosteal hemorrhages are uncommon and are usually attributed to increase in central venous pressure and bleeding disorders. Here, we report the case of a 38-year-old female who underwent an upper gastrointestinal (GI) endoscopy and developed bilateral nontraumatic subperiosteal hemorrhages that resolved with conservative treatment. Here, we discuss the source of bleeding and the mechanisms for the occurrence of orbital subperiosteal bleeds...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29713739/barium-upper-gi-series-in-adults-a-surgeon-s-perspective
#7
Daniel T Dempsey
Barium upper GI series performed by an interested and competent radiologist is still a very useful study to evaluate a variety of esophagogastric disorders. It usually provides information complementary to upper endoscopy and other foregut studies. Barium upper GI series is an important part of the diagnostic workup for gastroesophageal reflux disease, hiatal hernia, and esophageal motility disorders including achalasia. It is also an important part of the follow-up after operation for these common problems and after other operations such as resection or bariatric surgery...
June 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29707075/upper-and-lower-gastrointestinal-endoscopic-findings-in-hiv-infected-patients-in-the-era-of-highly-active-antiretroviral-therapy
#8
Russell Parvin, Sindhura Kolli, Jamil Shah, Manan Jhaveri, Madhavi Reddy
Background: Endoscopic evaluation with biopsies are instrumental in the diagnosis and management of gastrointestinal (GI) disorders in the setting of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS), especially in the era of highly active antiretroviral therapy (HAART). Methods: A retrospective chart review of 304 HIV-positive and 199 HIV-negative patients who had undergone upper and/or lower endoscopy in an urban community hospital from the years 2012 - 2017 was performed...
April 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29700641/bowel-perforation-in-type-iv-vascular-ehlers-danlos-syndrome-a-systematic-review
#9
H El Masri, T-H Loong, G Meurette, J Podevin, F Zinzindohoue, P-A Lehur
Spontaneous gastrointestinal (GI) perforation is a well-known complication occurring in patients suffering from Type IV vascular Ehlers-Danlos syndrome (EDS IV). The aim of the present study was to review the current literature on spontaneous GI perforation in EDS IV and illustrate the surgical management and outcome when possible. A systematic review of all the published data on EDS IV patients with spontaneous GI perforation between January 2000 and December 2015 was conducted using three major databases PUBMED, EMBASE, and Cochrane Central Register of Controlled Trails...
May 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29694969/clinical-features-of-hereditary-angioedema-in-korean-patients-a-nationwide-multicenter-study
#10
MULTICENTER STUDY
Jae-Woo Jung, Dong In Suh, Hye Jung Park, Sujeong Kim, Hyouk Soo Kwon, Min Suk Yang, Chan Sun Park, Joo-Hee Kim, Sae-Hoon Kim, Yong Won Lee, Gyu Young Hur, Young-Min Ye, Yong Eun Kwon, Hye-Kyung Park, Cheol Woo Kim, Young-Il Koh, Jung Wong Park, Jong-Myung Lee, Kyung-Up Min, Paige Wickner, Hye-Ryun Kang
BACKGROUND: Hereditary angioedema (HAE) is a genetically heterogeneous autosomal dominant disorder characterized by recurrent episodes of nonpruritic, nonpitting edema increasing after puberty. It can be fatal due to laryngeal or gastrointestinal (GI) involvement with varied and changing frequency of mortality according to studies published from the Western countries. Epidemiological and clinical data of HAE in Asian countries are sparse. We sought to examine the clinical characteristics of HAE patients in Korea...
2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29577672/cancer-risk-in-patients-with-alopecia-areata-a-nationwide-population-based-matched-cohort-study
#11
Chih-Chiang Chen, Yun-Ting Chang, Han-Nan Liu, Yi-Ju Chen
Alopecia areata (AA) is an organ-specific autoimmune disorder. Defective immune system related disorders are prone to increase the risk of cancer formation. However, the association among AA and variety of cancer types had never been studied. A nationwide population-based matched cohort study was conducted to evaluate the cancer risk in patients with AA. Records from Taiwan National Health Insurance Research Database were analyzed. Cases of AA from 1997 to 2013 and cancers registered in the catastrophic illness profile from the same time period were collected...
May 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29550791/relamorelin-and-other-ghrelin-receptor-agonists-future-options-for-gastroparesis-functional-dyspepsia-and-proton-pump-inhibitors-resistant-non-erosive-reflux-disease
#12
H Zatorski, P Mosinska, M Storr, J Fichna
There is an unmet need for effective pharmacological therapies for the treatment of gastroparesis and other upper gastrointestinal (GI) motility disorders, which reduce patients' quality of life and are a burden to the healthcare system. Ghrelin is an endogenous growth hormone secretagogue receptor ligand and has been shown to exert prokinetic effects on GI motility. Nevertheless, considering the short half-life of ghrelin its use in clinical practice is limited. Thus, ghrelin receptor agonists with enhanced pharmacokinetics were developed; they accelerate gastric emptying and improve symptoms of gastroparesis in animal models and humans...
December 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29545632/helicobacter-pylori-infection-does-not-protect-against-eosinophilic-esophagitis-results-from-a-large-multicenter-case-control-study
#13
Javier Molina-Infante, Carolina Gutierrez-Junquera, Edoardo Savarino, Roberto Penagini, Ines Modolell, Ottavia Bartolo, Alicia Prieto-García, Aurelio Mauro, Javier Alcedo, Antonia Perelló, Carlos Guarner-Argente, Noelia Alcaide, Ana M Vegas, Patricia Barros-García, Marianette Murzi-Pulgar, Monica Perona, Javier P Gisbert, Alfredo J Lucendo
OBJECTIVES: Rising trends in eosinophilic esophagitis (EoE) have been repeatedly linked to declining Helicobacter pylori (H. pylori) infection, mostly in retrospective studies. We aimed to prospectively evaluate this inverse association. METHODS: Prospective case-control study conducted in 23 centers. Children and adults naïve to eradication therapy for H. pylori were included. Cases were EoE patients, whereas controls were defined by esophageal symptoms and <5 eos/HPF on esophageal biopsies...
July 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29519608/the-impact-of-preoperative-investigations-on-the-management-of-bariatric-patients-results-of-a-cohort-of-more-than-1200-cases
#14
Romano Schneider, Ioannis Lazaridis, Marko Kraljević, Christoph Beglinger, Bettina Wölnerhanssen, Ralph Peterli
BACKGROUND: Despite the increasing use of bariatric surgery as the most effective treatment of morbid obesity, there is still no consensus on its preoperative diagnostic workup. The aim of this study was to identify the pathologies of the endoscopic and radiologic investigations before performing bariatric surgery and to evaluate their impact on the patient management. METHODS: Retrospective analysis of prospectively collected data of 1225 consecutive patients who underwent laparoscopic Roux-en-Y gastric bypass (n = 834) or sleeve gastrectomy (n = 391) at our institution...
May 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29514412/proton-pump-inhibitors-not-associated-with-hypomagnesemia-regardless-of-dose-or-concomitant-diuretic-use
#15
Monica Chowdhry, Kuldeep Shah, Suzanne Kemper, David Zekan, William Carter, Brittain McJunkin
BACKGROUND AND AIM: Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide, with dramatic efficacy for upper gastrointestinal acid-related disorders. In recent years, however, the safety of long-term PPI use has been questioned. One issue based on scant and conflicting literature is the possibility of PPI-related hypomagnesemia. Our purpose was to assess for any clinically significant alteration in serum magnesium levels in large groups of patients taking different PPIs in varying doses, with or without diuretics...
March 7, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29510215/factor-analysis-defines-distinct-upper-and-lower-gastrointestinal-symptom-groups-compatible-with-rome-iv-criteria-in-a-population-based-study
#16
Egbert Clevers, William E Whitehead, Olafur S Palsson, Ami D Sperber, Hans Törnblom, Lukas Van Oudenhove, Jan Tack, Magnus Simrén
BACKGROUND & AIMS: The Rome IV criteria define functional gastrointestinal (GI) disorders by specific combinations of symptoms. It is possible to empirically evaluate these symptom combinations by factor analysis (a statistical procedure that groups variables that correlate). However, this analysis has not been performed for the Rome IV criteria, and factor analyses based on the previous versions of the Rome criteria did not use population-based data. We therefore investigated symptom grouping by the Rome IV questionnaire using factor analysis of a population-based sample...
August 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29503558/the-frequency-risk-factors-and-complications-of-gastrointestinal-dysfunction-during-enteral-nutrition-in-critically-ill-patients
#17
Ayse Gulsah Atasever, Perihan Ergin Ozcan, Kamber Kasali, Taner Abdullah, Gunseli Orhun, Evren Senturk
Background: Gastrointestinal (GI) motility disorders in intensive care patients remain relatively unexplored. Nowadays, the frequency, risk factors and complications of GI dysfunction during enteral nutrition (EN) become more questionable. Aim: To evaluate the frequency, risk factors and complications of GI dysfunction during EN in the first 2 weeks of the intensive care unit (ICU) stay and to identify precautions to prevent the development of GI dysfunction and avoid complications...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29485007/pinpoint-localized-odynophagia-plo-as-a-specific-symptom-of-pill-induced-oesophagitis-pio-in-the-evaluation-of-acute-retrosternal-chest-pain
#18
Dhruvkumar Patel, Mukundkumar V Patel, Sanjay L Rajput, Kamal Sharma
INTRODUCTION: 36 out of 100 cases of retrosternal chest pains are due to oesophageal pathologies and pill-induced oesophagitis(PIO) is one of them. PIO can present as retrosternal chest pain associated with various gastrointestinal (GI) symptoms and require a high index of suspicion. PIO is a clinical diagnosis; and oesophagogastroscopy is required for confirmation of the diagnosis, to find out complications of PIO and to rule out other oesophageal disorders. Our aims of the present study were to study clinical profile, risk factors and endoscopic features of PIO...
February 26, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29480864/retrograde-gastroesophageal-intussusception-after-peroral-endoscopic-myotomy-in-a-patient-with-achalasia-cardia-a-case-report
#19
Samiullah Khan, Shuai Su, Kui Jiang, Bang-Mao Wang
RATIONALE: Retrograde gastroesophageal intussusception (RGEI) is a relatively rare gastrointestinal (GI) disorder in which a portion of the stomach wall invaginates into the esophagus. More recently, peroral endoscopic myotomy (POEM) has emerged as an endoscopic alternative to surgical myotomy for achalasia, and, to the best of our knowledge, our case is the first RGEI after POEM to be reported. PATIENT CONCERNS: A 22-year-old male was presented with a history of vomiting, intractable retching and hematemesis for 3 days...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29476195/-inflammatory-diseases-of-the-upper-gastrointestinal-tract-role-of-radiology-in-diagnostics
#20
REVIEW
G Böhm
BACKGROUND: The radiological evaluation of the upper gastrointestinal tract (GI tract) is a diagnostic challenge. Although endoscopy has pushed radiographic methods into the background, these methods continue to play a key role in the diagnosis of dysphagia. In addition, cross-sectional imaging (computed tomography, magnetic resonance imaging) is increasingly used in complex clinical cases to evaluate surrounding tissue changes. METHODS: By combining conventional double-contrast techniques with a video recording, the entire upper GI tract can be assessed both anatomically and functionally in one examination procedure...
April 2018: Der Radiologe
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