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Internal diseases

Badr Eldin Mostafa, Talaat Ali Elsamny, Tamer Ali Youssef, Ahmed Bahaa Elserwi, Ahmed Abdelmoneim Teaima
OBJECTIVE: To define anatomical variations associated with arterial blood supply of the nose which has clinical implications on the management of different disorders, especially intractable posterior epistaxis. STUDY DESIGN: Case series. METHODS: Selective angiography of external and internal carotid arteries of 100 patients scheduled for routine angiography was done. RESULTS: Different anatomical variations were documented...
October 18, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Angela Lamarca, Salvatore Galdy, Jorge Barriuso, Sharzad Moghadam, Elizabeth Beckett, Jane Rogan, Alison Backen, Catherine Billington, Mairéad G McNamara, Richard A Hubner, Angela Cramer, Juan W Valle
INTRODUCTION: Expression of human epidermal growth factor receptor (HER)2 and HER3 have been investigated in small BTC studies using variable scoring systems. METHODS: HER2 and HER3 overexpression/amplification were explored following internationally agreed guidelines using immunohistochemistry (IHC) and fluorescent in-situ hybridisation (FISH), respectively. Logistic regression and survival analysis (Kaplan Meier, Log rank test and Cox Regression) were used for statistical analysis...
2018: PloS One
Jeffrey W Mercante, Jason A Caravas, Maliha K Ishaq, Natalia A Kozak-Muiznieks, Brian H Raphael, Jonas M Winchell
Legionella spp. are the cause of a severe bacterial pneumonia known as Legionnaires' disease (LD). In some cases, current genetic subtyping methods cannot resolve LD outbreaks caused by common, potentially endemic L. pneumophila (Lp) sequence types (ST), which complicates laboratory investigations and environmental source attribution. In the United States (US), ST1 is the most prevalent clinical and environmental Lp sequence type. In order to characterize the ST1 population, we sequenced 289 outbreak and non-outbreak associated clinical and environmental ST1 and ST1-variant Lp strains from the US and, together with international isolate sequences, explored their genetic and geographic diversity...
2018: PloS One
Andrew M Scheidler, Dominique Kinnett-Hopkins, Yvonne C Learmonth, Robert Motl, Citlali López-Ortiz
BACKGROUND: Multiple sclerosis (MS) is a disease of the central nervous system that causes ataxia and deficits in balance. Exercise-based therapies have been identified as integral to the recovery of motor function in MS, but few studies have investigated non-traditional movement interventions. We examined a targeted ballet program (TBP) designed to mitigate ataxia and improve balance in females with mild-to-moderate relapsing-remitting MS. METHODS AND FINDINGS: Twelve females with mild-to-moderate disability due to MS were assessed for study eligibility for the study...
2018: PloS One
Giacomo Germani, Marie Laryea, Laura Rubbia-Brandt, Hiroto Egawa, Patrizia Burra, John O'Grady, Kymberly D Watt
Nonalcoholic steatohepatitis (NASH) is a growing indication for liver transplant whether the primary or secondary cause of liver disease, and it is expected to be the leading indication in the years to come. NASH recurs after transplant but the impact of the recurrence on allograft and patient outcomes is unclear. A group of multidisciplinary transplant practice providers convened at the International Liver Transplant Society NASH consensus conference with the purpose of determining the current knowledge and future directions for understanding the recurrence rates, risk and management of NASH in the transplant allograft...
October 17, 2018: Transplantation
Michael R Charlton, Edward J Gane, Akash Shukla, Bekhbold Dashtseren, Davaadorj Duger, David H Muljono, Diana A Payawal, Ganbolor Jargalsaikhan, Hery D Purnomo, Ian H Cua, Irsan Hasan, Jose Sollano, Khin Maung Win, Laurentius A Lesmana, Mohammad Salih, Pham Thi Thu Thuy, Ravi Shankar, Vivek A Saraswat
BACKGROUND: The population of Asia exceeds 4.4 billion people. Chronic hepatitis C virus (HCV) infection in Asia is characterized by specific distribution of genotypes, lack of access to specific therapeutic agents, relatively high cost of treatment, and lack of experienced healthcare providers. Clear consensus on the diagnosis, management, and monitoring of HCV infection specific to the Asian region is a major unmet need. The consensus guidelines documents that have been published to date by major medical societies presume access to an array of direct acting antiviral agents and diagnostic tests that are not broadly applicable to resource limited settings, including Asia...
October 17, 2018: Transplantation
Jean Ferrieres, Gaetano Maria De Ferrari, Michel P Hermans, Moses Elisaf, Peter P Toth, Martin Horack, Philippe Brudi, Dominik Lautsch, Lori D Bash, Carl A Baxter, Veronica Ashton, Baishali Ambegaonkar, Anselm K Gitt
Background Patients with coronary heart disease (CHD) and survivors of acute coronary syndrome (ACS) are at very high risk for adverse cardiovascular events. Lowering low-density lipoprotein cholesterol (LDL-C) can reduce the risk, with effective lipid-lowering therapy (LLT) readily available; however, dyslipidemia remains prevalent throughout Europe. Design The observational Dyslipidemia International Study II (DYSIS II) aimed to identify unmet treatment needs in adult ACS and CHD patients. Data for the seven participating European countries are presented herein...
October 18, 2018: European Journal of Preventive Cardiology
Tünde Csépány
The revolutionary progress of research in neuroimmu-nology has led to the introduction of disease modifying therapies in multiple sclerosis at the end of the last century. The International Panel on Diagnosis of Multiple Sclerosis originally proposed the 2001 McDonald criteria to facilitate the diagnosis of MS in patients with the first objective neurological symptom(s) suggesting demyelinating event, when magnetic resonance imaging is integrated with clinical and other paraclinical diagnostic methods. New terms have been introduced to substitute clinical information by MRI: dissemination in space - indicating a multifocal central demyelinating process and dissemination in time - indicating the development of new CNS lesions over time...
September 30, 2018: Ideggyógyászati Szemle
Péter Rajna, János Tajti
Two leading managers of the scientific journal currently publishing its 71st volume give an overview on the history and content- and form-related development of the journal. Recognizing the constantly decreasing role of paper-based literature products, the value system and the priorities of the journal were established more than 20 years ago: 1) preservation of high standards by achieving and maintaining international registration and annual qualification (i.e. impact factor); 2) enabling publication in Hungarian language for scientists living in Hungary and abroad; 3) displaying an ever broader spectrum of clinical neurosciences in the publications; 4) presentation of cutting-edge findings (related to the etiology, diagnostics, therapy, and care) of the most frequent and most relevant diseases in order to assure and enhance the quality of national clinical practice; 5) providing the possibility for the highest possible standard of scientific publication for Hungarian clinical neuroscientist; and finally 6) maintaining a readily available interaction surface and debate forum for the involved professionals in clinical questions of public interest...
September 30, 2018: Ideggyógyászati Szemle
Hana Brath, Nishila Mehta, Rachel D Savage, Sudeep S Gill, Wei Wu, Susan E Bronskill, Lynn Zhu, Jerry H Gurwitz, Paula A Rochon
OBJECTIVES: To systematically describe the resources available on preventing, detecting, and reversing prescribing cascades using a scoping review methodology. MEASUREMENTS: We searched Medline, EMBASE, PsychINFO, CINAHL, Cochrane Library, and Sociological Abstracts from inception until July 2017. Other searches (Google Scholar, hand searches) and expert consultations were performed for resources examining how to prevent, detect, or reverse prescribing cascades...
October 18, 2018: Journal of the American Geriatrics Society
Fabio Fabbian, Alfredo De Giorgi, Benedetta Boari, Elisa Misurati, Massimo Gallerani, Rosaria Cappadona, Rosario Cultrera, Roberto Manfredini, Maria A Rodrìguez Borrego, Pablo J Lopez-Soto
Infectious diseases (ID) are frequently cause of internal medicine wards (IMW) admission. We aimed to evaluate risk factors for in-hospital mortality (IHM) in IMW patients with ID, and to test the usefulness of a comorbidity score (CS).This study included ID hospital admissions between January 2013, and December 2016, recorded in the database of the local hospital. ICD-9-CM codes were selected to identify infections, development of sepsis, and to calculate a CS.We analyzed 12,173 records, (age 64.8 ± 25...
October 2018: Medicine (Baltimore)
Wan Syamimee Wan Ghazali, Saidatul Manera Mohd Daud, Nurashikin Mohammad, Kah Keng Wong
The aims of this study were to determine damage index in systemic lupus erythematosus (SLE) patients based on Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI) and to determine the laboratory and clinico-demographic factors affecting SDI.This is a retrospective cohort study of 94 SLE patients attending rheumatology clinics in 2 local hospitals in Kelantan, Malaysia. The patients were divided into 2 groups based on SDI score assigned by the attending physician, 0 (without damage) or ≥1 (with damage)...
October 2018: Medicine (Baltimore)
Natasha Alexander, Paula Marrano, Paul Thorner, Arlene Naranjo, Collin Van Ryn, Daniel Martinez, Vandana Batra, Libo Zhang, Meredith S Irwin, Sylvain Baruchel
Alternative radiolabeled, targeted agents are being investigated for children with relapsed neuroblastoma (NB) who do not respond to I-metaiodobenzylguanidine (MIBG) therapy. (DOTA-Tyr)-octreotate targets somatostatin receptors (SSTRs), particularly SSTR2, which are expressed on NB cells. We investigated SSTR2 expression in NB tumors (36 high-risk [HR]; 33 non-HR patients) and correlated SSTR2 levels with clinical features, norepinephrine transporter (NET) expression, and MIBG avidity. SSTR2 and NET immunohistochemistry scores (0 to 3) were calculated on biopsies using digital image analysis based on staining intensity and distribution...
October 16, 2018: Journal of Pediatric Hematology/oncology
Amanda Nicole Fletcher, Richard M Schwend, Mitchell Solano, Christopher Wester, Dale E Jarka
BACKGROUND: Unintentional injuries are the leading cause of morbidity and mortality among children 0 to 18 years of age in the U.S. An estimated 9,400 to 17,000 pediatric lawn-mower injuries occur each year. The aims of this study were to better define the epidemiology of lawn-mower injuries and to identify predictors of severe lawn-mower injuries to optimize public education and injury prevention. METHODS: All patients 0 to 18 years of age who presented to Children's Mercy Hospital (CMH), Kansas City, Missouri, during the period of 1995 to 2015 after sustaining a lawn-mower injury were identified using International Classification of Diseases, 9th Revision (ICD-9) codes...
October 17, 2018: Journal of Bone and Joint Surgery. American Volume
Kai Dallas, Christopher S Elliott, Raveen Syan, Ericka Sohlberg, Ekene Enemchukwu, Lisa Rogo-Gupta
OBJECTIVE: To evaluate the association of hysterectomy at the time of pelvic organ prolapse (POP) repair with the risk of undergoing subsequent POP surgery in a large population-based cohort. METHODS: Data from the California Office of Statewide Health Planning and Development were used in this retrospective cohort study to identify all women who underwent an anterior, apical, posterior or multiple compartment POP repair at nonfederal hospitals between January 1, 2005, and December 31, 2011, using Current Procedural Terminology and International Classification of Diseases, 9th Revision procedure codes...
October 15, 2018: Obstetrics and Gynecology
Lauren A Gard, Jonna Peterson, Corrine Miller, Nilasha Ghosh, Quentin Youmans, Aashish Didwania, Stephen D Persell, Muriel Jean-Jacques, Paul Ravenna, Matthew J O'Brien, Mita Sanghavi Goel
PURPOSE: Medical training has traditionally focused on the proximate determinants of disease, with little focus on how social conditions influence health. The authors conducted a scoping review of existing curricula to understand the current programs designed to teach primary care residents about the social determinants of health (SDH). METHOD: In January and March 2017, the authors searched seven databases. Eligible articles focused on primary care residents, described a curriculum related to SDH, were published between January 2007 and January 2017, and were based in the United States...
October 16, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
Jie Wang, Jian-Xiong Ma, Shao-Wen Zhu, Hao-Bo Jia, Xin-Long Ma
BACKGROUND: Acromioclavicular joint arthritis is a common, painful, and often missed diagnosis, and it often accompanies other shoulder conditions such as rotator cuff disease. Whether distal clavicle resection is important to perform in patients undergoing surgery for rotator cuff tears and concomitant acromioclavicular joint arthritis is controversial. QUESTIONS/PURPOSES: The purpose of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of distal clavicle resection on (1) outcome scores; (2) shoulder ROM, joint pain or tenderness, and joint instability; and (3) risk of reoperation among patients treated surgically for rotator cuff tears who had concomitant acromioclavicular joint arthritis...
October 16, 2018: Clinical Orthopaedics and related Research
Jerome B Taxy, Harry M Goldin, Sara Dickie, Thomas Cibull
The ulcerated papules of cutaneous leishmaniasis represent an unusual form of granulomatous dermatitis caused by Leishmania species, a protozoan transmitted by sandfly bites. As the disease is not native to North America, clinical suspicion is partially based on a compatible travel history and may result in a biopsy. The key role of standard morphology is the identification of Leishmania organisms, supplemented by Giemsa and/or CD1a immunostaining. Histologically, the organism may be confused with Histoplasma species, which is resolved by staining with methenamine silver or PAS...
October 16, 2018: American Journal of Surgical Pathology
Frank Kowalzik, Harald Binder, Daniela Zöller, Margarita Riera-Montes, Ralf Clemens, Thomas Verstraeten, Fred Zepp
We estimated numbers of hospitalizations for norovirus gastroenteritis (NGE) and associated medical costs in Germany, where norovirus testing is high because reimbursement is affected. We extracted aggregate data for patients hospitalized with a primary or secondary code from the International Classification of Diseases, 10th Revision (ICD-10), NGE diagnosis during 2007-2012 from the German Federal Statistics Office. We assessed reliability of the coding system in patient records from a large academic hospital...
November 2018: Emerging Infectious Diseases
Krisztián Kállay, Judit Csomor, Emma Ádám, Csaba Bödör, Csaba Kassa, Réka Simon, Gábor Kovács, György Péter, Gábor Ottóffy, Katalin Bartyik, Csongor Kiss, Péter Masát, Marienn Réti, Blanka Tóth, Gergely Kriván
INTRODUCTION: Acquired bone marrow failures are rare but fatal diseases in childhood. Since 2013, Hungary has been participating as a full member in the work of the European Working Group on uniform diagnostics and therapy in patients with acquired bone marrow failure syndromes. Hypocellular refractory cytopenia of childhood has been emphasized as a frequent entity, transplanted by reduced intensity conditioning with excellent outcomes. AIM: To analyse and compare the results of treatment before and after our joining...
October 2018: Orvosi Hetilap
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