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https://www.readbyqxmd.com/read/30226603/overexpression-of-epsin-3-enhances-migration-and-invasion-of-glioma-cells-by-inducing-epithelial%C3%A2-mesenchymal-transition
#1
Yaru Wang, Wen Song, Pengcheng Kan, Chao Huang, Zhuolin Ma, Qiaoli Wu, Xiuhua Yao, Biao Zhang
Epsin 3 (EPN3) expression is limited to gastric parietal cells and wounded or pathological tissue rather than normal brain tissue, and although it has been identified as an oncogene in estrogen receptor‑positive breast cancer and non‑small cell lung cancer, its function in cancer is poorly understood. The present study aimed to investigate the association of EPN3 expression with the clinicopathological features of patients with glioma, as well as the effects of EPN3 on glioblastoma cells and the potential molecular mechanisms for its effects on glioblastoma cell behavior...
November 2018: Oncology Reports
https://www.readbyqxmd.com/read/30216763/sorcin-a-potential-molecular-target-for-cancer-therapy
#2
REVIEW
Bano Shabnam, Ganesan Padmavathi, Kishore Banik, Sosmitha Girisa, Javadi Monisha, Gautam Sethi, Lu Fan, Lingzhi Wang, Xinliang Mao, Ajaikumar B Kunnumakkara
Sorcin (Soluble resistance related calcium binding protein) is a small soluble penta EF family (PEF) of calcium (Ca2+ ) binding protein (22,000 Da). It has been reported to play crucial roles in the regulation of calcium homeostasis, apoptosis, vesicle trafficking, cancer development, and multidrug resistance (MDR). Overexpression of sorcin has been reported to be associated with different cancers such as breast cancer, colorectal cancer, gastric cancer, leukemia, lung cancer, nasopharyngeal cancer, ovarian cancer, etc...
September 11, 2018: Translational Oncology
https://www.readbyqxmd.com/read/30027971/distributions-of-manganese-in-diverse-human-cancers-provide-insights-into-tumour-radioresistance
#3
Philip A Doble, George L Gabor Miklos
Many cancers are variably resistant to radiation treatment: some patients die within months, while others with the same tumour type and equivalent radiation protocol, survive for years. To determine why some tumours are radiosensitive, while others return after radiotherapy, requires new non-traditional approaches to oncology. Herein we used laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) to test the hypothesis that Mn functions as a metabolic radioprotector and is an apex predictor of tumour radioresponsiveness...
September 19, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29211451/clip6-pna-peptide-conjugates-non-endosomal-delivery-of-splice-switching-oligonucleotides
#4
Terese Soudah, Maxim Mogilevsky, Rotem Karni, Eylon Yavin
Efficient delivery of oligonucleotides still remains a challenge in the field of oligonucleotide based therapy. Peptide nucleic acid (PNA), a DNA analogue that is typically synthesized by solid phase peptide chemistry, has been conjugated to a variety of cell penetrating peptides (CPP) as a means of improving its cellular uptake. These CPPs typically deliver their cargoes into cells by an endosomal-dependent mechanism resulting in lower bioavailability of the cargo. Herein, we designed and synthesized PNA-peptide conjugates as splice switching oligonucleotides (SSO) targeting the Mnk2 gene, a therapeutic target in cancer...
December 20, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29135607/targeting-the-perivascular-niche-in-brain-tumors
#5
REVIEW
Giorgio Seano
PURPOSE OF REVIEW: Brain tumors are composed of primary tumors of the central nervous system, such us glioblastoma (GBM), and secondary metastatic tumors, such as melanoma, non-Hodgkin lymphoma as well as lung and breast cancers. Brain tumors are highly deadly, and unfortunately not many improvements have been achieved to improve the survival of patients with brain tumors. Chemoradiation resistance is one of the most clinically relevant challenges faced in patients with brain tumors. The perivascular niche is one of the most relevant microenvironment hubs in brain tumors...
January 2018: Current Opinion in Oncology
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