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aortic dissection inflammation

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https://www.readbyqxmd.com/read/30510150/correction-cd40l-promotes-development-of-acute-aortic-dissection-via-induction-of-inflammation-and-impairment-of-endothelial-cell-function
#1
Lu Han, Lu Dai, Yuan-Fei Zhao, Hai-Yang Li, Ou Liu, Feng Lan, Wen-Jian Jiang, Hong-Jia Zhang
No abstract text is available yet for this article.
November 16, 2018: Aging
https://www.readbyqxmd.com/read/30487492/comparison-of-two-laboratory-methods-of-preservation-for-preclinical-preparation-of-bovine-aortic-heart-valve-suitable-for-human-use
#2
S A Sunny, M A Hossain, A B Adhikary
The present experimental study was carried out as an experimental study in the department of Cardiac Surgery at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2011 to May 2013 to see which preservation techniques give us morphologically and histologically suitable xenograft heart valve for clinical use. We reviewed 20 bovine aortic valves in 2 years. Each of 10 samples was grouped as glutaraldehyde (1.5%) preservation and cryopreservation (-180°C). After collecting each specimen, sterilization of valve was done in low concentration of sterile antibiotic solution (CLPVA)...
October 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/30391968/neovascularization-with-chronic-inflammation-characterizes-ascending-aortic-dissection
#3
Eetu Niinimäk, Ville Pynnönen, Ivana Kholova, Timo Paavonen, Ari Mennander
OBJECTIVE: Neovascularization of the aortic wall may be associated with aortic dissection (AD). Aortic wall endothelial CD31 deposition together with chronic inflammation indicates angiogenesis that may lead to tissue disruption. We studied the presence of neovascularization of the ascending aortic wall by characterizing CD31 positive endothelial cells. METHODS: Aortic wall routine histology and immunohistochemistry for CD31, T- and B-lymphocytes, plasma cells, macrophages, endothelial cells, smooth muscle cells, and cell proliferation were performed on 35 selected patients who underwent surgery for the ascending aorta, and the samples were grouped according to the presence of AD...
November 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/30372831/mechanical-stretch-aggravates-aortic-dissection-by-regulating-mapk-pathway-and-the-expression-of-mmp-9-and-inflammation-factors
#4
Yunnan Hu, Lin Lu, Zhihuang Qiu, Qiuyu Huang, Yinhai Chen, Liangwan Chen
This study aimed to explore whether mechanical stretch aggravated aortic dissection through regulating MAPK pathway, MMP-9, and inflammation factors. We first established aortic dissection model rats. Mechanical stretch (3 g) was exerted on vascular ring of aortic dissection which was also treated by inhibitors of MAPK pathway (SB203580, SP600125, and U0126). HE and Masson staining showed that aortic dissection severity with 3 g tension was worse than that without tension (0 g); after the treatments of diverse inhibitors, the fracture and breakage of the elastic fibers decreased...
December 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30359839/renal-cystic-disease-in-the-fbn1-c1039g-marfan-mouse-is-associated-with-enhanced-aortic-aneurysm-formation
#5
Stijntje Hibender, Shaynah Wanga, Ingeborg van der Made, Mariska Vos, Barbara Jm Mulder, Ron Balm, Carlie Jm de Vries, Vivian de Waard
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 gene (FBN1), resulting in aortic aneurysm formation and dissections. Interestingly, variable aortopathy is observed even within MFS families with the same mutation. Thus, additional risk factors determine disease severity. Here, we describe a case of a 2-month-old Fbn1C1039G/+ MFS mouse with extreme aortic dilatation and increased vascular inflammation, when compared to MFS siblings, which coincided with unilateral renal cystic disease...
October 16, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/30324867/contrast-enhanced-ultrasound-of-the-abdominal-aorta-current-status-and-future-perspectives
#6
Xin Li, Daniel Staub, Vasileios Rafailidis, Mohammed Al-Natour, Sanjeeva Kalva, Sasan Partovi
Ultrasound has been established as an important diagnostic tool in assessing vascular abnormalities. Standard B-mode and Doppler techniques have inherent limitations with regards to detection of slow flow and small vasculature. Contrast-enhanced ultrasound (CEUS) is a complementary tool and is useful in assessing both the macro- and microvascular anatomy of the aorta. CEUS can also provide valuable physiological information in real-time scanning sessions due to the physical and safety profiles of the administered microbubbles...
October 16, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/30303488/development-of-a-novel-aortic-dissection-mouse-model-and-evaluation-of-drug-efficacy-using-in-vivo-assays-and-database-analyses
#7
Yuki Izawa-Ishizawa, Masaki Imanishi, Yoshito Zamami, Hiroki Toya, Tomoko Nagao, Marin Morishita, Koichi Tsuneyama, Yuya Horinouchi, Yoshitaka Kihira, Kenshi Takechi, Yasumasa Ikeda, Koichiro Tsuchiya, Masanori Yoshizumi, Toshiaki Tamaki, Keisuke Ishizawa
OBJECTIVE: Aortic dissection is a life-threatening disease. At present, the only therapeutic strategies available are surgery and antihypertensive drugs. Moreover, the molecular mechanisms underlying the onset of aortic dissection are still unclear. We established a novel aortic dissection model in mice using pharmacologically induced endothelial dysfunction. We then used the Japanese Adverse Drug Event Report database to investigate the role of pitavastatin in preventing the onset of aortic dissection...
January 2019: Journal of Hypertension
https://www.readbyqxmd.com/read/30299239/successful-use-of-rituximab-in-granulomatosis-with-polyangiitis-with-aortic-inflammation
#8
Lucas Pineda Bernal, Nicole Bitencourt, Kiran Batra, Elizabeth Blair Solow
Large vessel inflammation, although rare, has been increasingly recognised as a complication of granulomatosis with polyangiitis (GPA) in recent years. The presentation is highly variable, ranging from an incidental finding to aortic dissection and rupture. Treatment has predominately consisted of a combination of cyclophosphamide and high dose corticosteroids with surgical intervention when indicated. We present the case of a 34-year-old male diagnosed with GPA after presenting with sinus and eye inflammation and the ensuing investigation revealed large vessel involvement that remarkably improved after 6 months of treatment with the combination of rituximab infusions, methotrexate and corticosteroids...
September 20, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/30264146/characteristics-of-spontaneous-spinal-cord-infarction-and-proposed-diagnostic-criteria
#9
Nicholas L Zalewski, Alejandro A Rabinstein, Karl N Krecke, Robert D Brown, Eelco F M Wijdicks, Brian G Weinshenker, Timothy J Kaufmann, Jonathan M Morris, Allen J Aksamit, J D Bartleson, Giuseppe Lanzino, Melissa M Blessing, Eoin P Flanagan
Importance: Spinal cord infarction (SCI) is often disabling, and the diagnosis can be challenging without an inciting event (eg, aortic surgery). Patients with a spontaneous SCI are often misdiagnosed as having transverse myelitis. Diagnostic criteria for SCI are lacking, hindering clinical care and research. Objective: To describe the characteristics of spontaneous SCI and propose diagnostic criteria. Design, Setting, and Participants: An institution-based search tool was used to identify patients evaluated at Mayo Clinic, Rochester, Minnesota, from January 1997 to December 2017 with a spontaneous SCI...
September 24, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/30191627/postnatal-deficiency-of-adamts1-ameliorates-thoracic-aortic-aneurysm-and-dissection-in-mice
#10
Shanshan Wang, Yuting Liu, Guizhen Zhao, Li He, Yi Fu, Changan Yu, Zhizhi Wang, Tingting Zhao, Fan Cao, Yanxiang Gao, Wei Kong, Jingang Zheng
NEW FINDINGS: What is the central question of this study? Thoracic aortic aneurysm and dissection (TAAD) is characterized by extracellular matrix remodelling and an inflammatory response. Evidence suggests that ADAMTS1 is closely associated with TAAD development, but whether it contributes to the pathophysiology of TAAD remains unknown. What is the main finding and its importance? We generated inducible postnatal ADAMTS1 knockout mice and found that ADAMTS1 deficiency attenuated β-aminopropionitrile-dependent TAAD formation and rupture...
December 2018: Experimental Physiology
https://www.readbyqxmd.com/read/30088482/effect-of-inflammation-on-the-biomechanical-strength-of-involved-aorta-in-type-a-aortic-dissection-and-ascending-thoracic-aortic-aneurysm-an-initial-research
#11
Zhixuan Bai, Jun Gu, Yingkang Shi, Wei Meng
OBJECTIVE: Type A aortic dissection (AD) and ascending thoracic aortic aneurysm (AA) are thoracic vascular diseases with similar initial pathology but inequable clinical features and outcomes, where local and systemic inflammation play an important part. We aimed to observe and analyze the differences and correlation between inflammation and pathological changes in the aorta and biomechanical strength between AD and AA. METHODS: From August 2011 to February 2013, 20 patients with AD (AD group) and 13 patients with AA (AA group) who underwent aorta surgery were included...
August 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/30072126/serum-levels-of-complement-c1q-tumor-necrosis-factor-related-protein-3-decreased-in-patients-with-acute-aortic-dissection
#12
Huimin Jiang, Menglong Wang, Jing Ye, Jianfang Liu, Zhen Wang, Yao Xu, Di Ye, Jun Wan
Complement-C1q/tumor necrosis factor-related protein-3 (CTRP3) is one kind of adipocytokines and has been reported to play key roles in many cardiovascular diseases by regulating inflammation. Inflammation was reported to be involved in the development of acute aortic dissection (AAD). The purpose of this study was to investigate whether serum levels of CTRP3 were associated with AAD. The serum was collected from 108 participants, including 60 patients with AAD and 32 patients with hypertension, as well as 16 healthy subjects...
October 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29982301/conflicting-vascular-and-metabolic-impact-of-the-il-33-sst2-axis
#13
Raffaele Altara, Rana Ghali, Ziad Mallat, Alessandro Cataliotti, George W Booz, Fouad A Zouein
Interleukin 33 (IL-33), which is expressed by several immune cell types, endothelial and epithelial cells, and fibroblasts, is a cytokine of the IL-1 family that acts both intra- and extracellularly to either enhance or resolve the inflammatory response. Intracellular IL-33 acts in the nucleus as a regulator of transcription. Once released from cells by mechanical stress, inflammatory cytokines, or necrosis, extracellular IL-33 is proteolytically processed to act in an autocrine/paracrine manner as an 'alarmin' on neighbouring or various immune cells expressing the ST2 receptor...
October 1, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29868945/predictors-of-oxygenation-impairment-in-medical-treatment-for-type-b-acute-aortic-dissection
#14
Yusuke Kashiwagi, Kimiaki Komukai, Kenichiro Suzuki, Yuhei Oi, Mitsutoshi Tominaga, Kotaro Nakata, Satoru Miyanaga, Tetsuya Ishikawa, Kosuke Minai, Tomohisa Nagoshi, Michihiro Yoshimura
Lung oxygenation impairment often occurs in patients with type B acute aortic dissection (AAD), necessitating mechanical ventilation. Patients receiving mechanical ventilation are at risk of complications, so a low-oxygen condition requiring mechanical ventilation should be avoided. We explored the predictors of oxygenation impairment. We enrolled 46 patients with type B AAD who had been medically treated and underwent computed tomography. Blood was sampled to measure markers of inflammation, such as the C-reactive protein (CRP) levels and white blood cell count...
June 4, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29729633/thrombospondin-4-mediates-cardiovascular-remodelling-in-angiotensin-ii-induced-hypertension
#15
Teresa Palao, Lejla Medzikovic, Catarina Rippe, Shaynah Wanga, Claudia Al-Mardini, Angela van Weert, Judith de Vos, Nicole N van der Wel, Henk A van Veen, Ed T van Bavel, Karl Swärd, Vivian de Waard, Erik Ntp Bakker
Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated Thrombospondin 4 knockout (Thbs4-/- ) mice. We reported increased heart weight, as well as the occurrence of aortic aneurysms in the Ang II-treated Thbs4-/- animals...
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29707315/inflammation-is-related-to-preoperative-hypoxemia-in-patients-with-acute-stanford-type-a-aortic-dissection
#16
Xu-Zhou Duan, Zhi-Yun Xu, Fang-Lin Lu, Lin Han, Yang-Feng Tang, Hao Tang, Yang Liu
Background: Preoperative hypoxemia is a frequent complication of acute Stanford type A aortic dissection (ATAAD). The aim of the present study was to determine which factors were associated with hypoxemia. Methods: A series of data were collected in a statistical analysis to evaluate preoperative hypoxemia in patients with ATAAD. After retrospectively analyzing data for 172 patients, we identified the risk factors for preoperative hypoxemia. Hypoxemia was defined by an arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2 /FiO2 ) ratio of 200 or lower...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29701396/takayasus-s-aortitis-induced-ascending-aorta-dissection
#17
Bruno Fernandes, Joana Saraiva, Lina Carvalho
INTRODUCTION: Takayasu aortitis is a well known yet rare form of large vessel vasculitis. Also known as pulseless disease, occlusive thromboaortopathy, and Martorell syndrome, is a chronic inflammatory aortitis. Vessel inflammation leads to wall thickening, fibrosis, stenosis, and thrombus formation. METHODS: A 64-year-old woman was referred to emergency for lack of pulse in the upper and lower limbs and changes in heart rate. AngioRMN revealed dissection of the ascending aorta while in PET, intense uptake of FDG-F18 involving ascending, crossa, descending thoracic and abdominal segments of the aorta, was evident urgent surgical correction occurred...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29685513/expression-of-platelet-derived-growth-factor-b-is-upregulated-in-patients-with-thoracic-aortic-dissection
#18
Weixin Meng, Shangdian Liu, Dandan Li, Zonghong Liu, Hui Yang, Bo Sun, Hongyu Liu
OBJECTIVE: Thoracic aortic dissection (TAD) is a serious condition requiring urgent treatment to avoid catastrophic consequences. The inflammatory response is involved in the occurrence and development of TAD, possibly potentiated by platelet-derived growth factors (PDGFs). This study aimed to determine whether expression of PDGF-B (a subunit of PDGF-BB) was increased in TAD patients and to explore the factors responsible for its upregulation and subsequent effects on TAD. METHODS: Full-thickness ascending aorta wall specimens from TAD patients (n = 15) and control patients (n = 10) were examined for expression of PDGF-B and its receptor (PDGFRB) and in terms of morphology, inflammation, and fibrosis...
April 20, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29642385/micrornas-as-potential-mediators-for-cigarette-smoking-induced-atherosclerosis
#19
Yuka Yokoyama, Nathan Mise, Yuka Suzuki, Saeko Tada-Oikawa, Kiyora Izuoka, Lingyi Zhang, Cai Zong, Akira Takai, Yoshiji Yamada, Sahoko Ichihara
Smoking increases the risk of atherosclerosis-related events, such as myocardial infarction and ischemic stroke. Recent studies have examined the expression levels of altered microRNAs (miRNAs) in various diseases. The profiles of tissue miRNAs can be potentially used in diagnosis or prognosis. However, there are limited studies on miRNAs following exposure to cigarette smoke (CS). The present study was designed to dissect the effects and cellular/molecular mechanisms of CS-induced atherosclerogenesis. Apolipoprotein E knockout (ApoE KO) mice were exposed to CS for five days a week for two months at low (two puffs/min for 40 min/day) or high dose (two puffs/min for 120 min/day)...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29628463/-vascular-smooth-muscle-cell-response-to-cyclic-mechanical-stretch-and-aortic-dissection
#20
Masanori Yoshizumi, Jing Zhao, Yoji Kyotani
Acute aortic dissection is the most common life-threatening vascular disease, with sudden onset of severe pain and a high fatality rate. The pulsatile nature of blood flow exposes vascular smooth muscle cells (VSMCs) in the vessel wall to cyclic mechanical stretch (CMS), which evokes VSMC death, phenotypic switching, and migration, leading to aortic dissection. We have revealed that CMS of rat aortic smooth muscle cells (RASMCs) caused JNK- and p38-dependent cell death and that a calcium channel blocker, azelnidipine and an angiotensin II receptor antagonist, olmesartan decreased the phosphorylation of JNK and p38 and, subsequently, decreased cell death by CMS...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
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