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aortic dissection inflammation

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https://www.readbyqxmd.com/read/30088482/effect-of-inflammation-on-the-biomechanical-strength-of-involved-aorta-in-type-a-aortic-dissection-and-ascending-thoracic-aortic-aneurysm-an-initial-research
#1
Zhixuan Bai, Jun Gu, Yingkang Shi, Wei Meng
OBJECTIVE: Type A aortic dissection (AD) and ascending thoracic aortic aneurysm (AA) are thoracic vascular diseases with similar initial pathology but inequable clinical features and outcomes, where local and systemic inflammation play an important part. We aimed to observe and analyze the differences and correlation between inflammation and pathological changes in the aorta and biomechanical strength between AD and AA. METHODS: From August 2011 to February 2013, 20 patients with AD (AD group) and 13 patients with AA (AA group) who underwent aorta surgery were included...
August 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/30072126/serum-levels-of-complement-c1q-tumor-necrosis-factor-related-protein-3-decreased-in-patients-with-acute-aortic-dissection
#2
Huimin Jiang, Menglong Wang, Jing Ye, Jianfang Liu, Zhen Wang, Yao Xu, Di Ye, Jun Wan
Complement-C1q/tumor necrosis factor-related protein-3 (CTRP3) is one kind of adipocytokines and has been reported to play key roles in many cardiovascular diseases by regulating inflammation. Inflammation was reported to be involved in the development of acute aortic dissection (AAD). The purpose of this study was to investigate whether serum levels of CTRP3 were associated with AAD. The serum was collected from 108 participants, including 60 patients with AAD and 32 patients with hypertension, as well as 16 healthy subjects...
July 4, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29982301/conflicting-vascular-and-metabolic-impact-of-the-il-33-sst2-axis
#3
Raffaele Altara, Rana Ghali, Ziad Mallat, Alessandro Cataliotti, George W Booz, Fouad A Zouein
Interleukin 33 (IL-33), which is expressed by several immune cell types, endothelial and epithelial cells, and fibroblasts, is a cytokine of the IL-1 family that acts both intra- and extracellularly to either enhance or resolve the inflammatory response. Intracellular IL-33 acts in the nucleus as a regulator of transcription. Once released from cells by mechanical stress, inflammatory cytokines, or necrosis, extracellular IL-33 is proteolytically processed to act in an autocrine/paracrine manner as an "alarmin" on neighboring or various immune cells expressing the ST2 receptor...
July 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29868945/predictors-of-oxygenation-impairment-in-medical-treatment-for-type-b-acute-aortic-dissection
#4
Yusuke Kashiwagi, Kimiaki Komukai, Kenichiro Suzuki, Yuhei Oi, Mitsutoshi Tominaga, Kotaro Nakata, Satoru Miyanaga, Tetsuya Ishikawa, Kosuke Minai, Tomohisa Nagoshi, Michihiro Yoshimura
Lung oxygenation impairment often occurs in patients with type B acute aortic dissection (AAD), necessitating mechanical ventilation. Patients receiving mechanical ventilation are at risk of complications, so a low-oxygen condition requiring mechanical ventilation should be avoided. We explored the predictors of oxygenation impairment. We enrolled 46 patients with type B AAD who had been medically treated and underwent computed tomography. Blood was sampled to measure markers of inflammation, such as the C-reactive protein (CRP) levels and white blood cell count...
June 4, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29729633/thrombospondin-4-mediates-cardiovascular-remodelling-in-angiotensin-ii-induced-hypertension
#5
Teresa Palao, Lejla Medzikovic, Catarina Rippe, Shaynah Wanga, Claudia Al-Mardini, Angela van Weert, Judith de Vos, Nicole N van der Wel, Henk A van Veen, Ed T van Bavel, Karl Swärd, Vivian de Waard, Erik Ntp Bakker
Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated Thrombospondin 4 knockout (Thbs4-/- ) mice. We reported increased heart weight, as well as the occurrence of aortic aneurysms in the Ang II-treated Thbs4-/- animals...
July 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29707315/inflammation-is-related-to-preoperative-hypoxemia-in-patients-with-acute-stanford-type-a-aortic-dissection
#6
Xu-Zhou Duan, Zhi-Yun Xu, Fang-Lin Lu, Lin Han, Yang-Feng Tang, Hao Tang, Yang Liu
Background: Preoperative hypoxemia is a frequent complication of acute Stanford type A aortic dissection (ATAAD). The aim of the present study was to determine which factors were associated with hypoxemia. Methods: A series of data were collected in a statistical analysis to evaluate preoperative hypoxemia in patients with ATAAD. After retrospectively analyzing data for 172 patients, we identified the risk factors for preoperative hypoxemia. Hypoxemia was defined by an arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2 /FiO2 ) ratio of 200 or lower...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29701396/takayasus-s-aortitis-induced-ascending-aorta-dissection
#7
Bruno Fernandes, Joana Saraiva, Lina Carvalho
INTRODUCTION: Takayasu aortitis is a well known yet rare form of large vessel vasculitis. Also known as pulseless disease, occlusive thromboaortopathy, and Martorell syndrome, is a chronic inflammatory aortitis. Vessel inflammation leads to wall thickening, fibrosis, stenosis, and thrombus formation. METHODS: A 64-year-old woman was referred to emergency for lack of pulse in the upper and lower limbs and changes in heart rate. AngioRMN revealed dissection of the ascending aorta while in PET, intense uptake of FDG-F18 involving ascending, crossa, descending thoracic and abdominal segments of the aorta, was evident urgent surgical correction occurred...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29685513/expression-of-platelet-derived-growth-factor-b-is-upregulated-in-patients-with-thoracic-aortic-dissection
#8
Weixin Meng, Shangdian Liu, Dandan Li, Zonghong Liu, Hui Yang, Bo Sun, Hongyu Liu
OBJECTIVE: Thoracic aortic dissection (TAD) is a serious condition requiring urgent treatment to avoid catastrophic consequences. The inflammatory response is involved in the occurrence and development of TAD, possibly potentiated by platelet-derived growth factors (PDGFs). This study aimed to determine whether expression of PDGF-B (a subunit of PDGF-BB) was increased in TAD patients and to explore the factors responsible for its upregulation and subsequent effects on TAD. METHODS: Full-thickness ascending aorta wall specimens from TAD patients (n = 15) and control patients (n = 10) were examined for expression of PDGF-B and its receptor (PDGFRB) and in terms of morphology, inflammation, and fibrosis...
April 20, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29642385/micrornas-as-potential-mediators-for-cigarette-smoking-induced-atherosclerosis
#9
Yuka Yokoyama, Nathan Mise, Yuka Suzuki, Saeko Tada-Oikawa, Kiyora Izuoka, Lingyi Zhang, Cai Zong, Akira Takai, Yoshiji Yamada, Sahoko Ichihara
Smoking increases the risk of atherosclerosis-related events, such as myocardial infarction and ischemic stroke. Recent studies have examined the expression levels of altered microRNAs (miRNAs) in various diseases. The profiles of tissue miRNAs can be potentially used in diagnosis or prognosis. However, there are limited studies on miRNAs following exposure to cigarette smoke (CS). The present study was designed to dissect the effects and cellular/molecular mechanisms of CS-induced atherosclerogenesis. Apolipoprotein E knockout (ApoE KO) mice were exposed to CS for five days a week for two months at low (two puffs/min for 40 min/day) or high dose (two puffs/min for 120 min/day)...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29628463/-vascular-smooth-muscle-cell-response-to-cyclic-mechanical-stretch-and-aortic-dissection
#10
Masanori Yoshizumi, Jing Zhao, Yoji Kyotani
Acute aortic dissection is the most common life-threatening vascular disease, with sudden onset of severe pain and a high fatality rate. The pulsatile nature of blood flow exposes vascular smooth muscle cells (VSMCs) in the vessel wall to cyclic mechanical stretch (CMS), which evokes VSMC death, phenotypic switching, and migration, leading to aortic dissection. We have revealed that CMS of rat aortic smooth muscle cells (RASMCs) caused JNK- and p38-dependent cell death and that a calcium channel blocker, azelnidipine and an angiotensin II receptor antagonist, olmesartan decreased the phosphorylation of JNK and p38 and, subsequently, decreased cell death by CMS...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29603401/platelet-to-lymphocyte-ratio-in-acute-aortic-dissection
#11
Eftihia Sbarouni, Panagiota Georgiadou, Elias Kosmas, Antonis Analitis, Vassilis Voudris
BACKGROUND: Inflammation plays an important role in the initiation and progression of acute aortic dissection (AAD). New inflammatory indices derived from full cell blood count and its differential may be associated with increased risk. We evaluated platelet-lymphocyte (PLR), red cell distribution width (RDW) and RDW/PLT's (platelets) (RPR) in AAD. METHODS: We studied 120 consecutive patients with AAD type I admitted for emergency surgery (group I), 121 consecutive patients with aortic aneurysms of the ascending aorta prior to elective repair (group II) and 121 controls (group III), age and sex matched...
March 30, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29589594/mercaptoethanol-protects-the-aorta-from-dissection-by-inhibiting-oxidative-stress-inflammation-and-extracellular-matrix-degeneration-in-a-mouse-model
#12
Lei Zhang, Changtian Wang, Zhilong Xi, Demin Li, Zhiyun Xu
BACKGROUND The aims of this study were to investigate the effects of mercaptoethanol treatment on the expression of mediators of oxidative stress, inflammation, and extracellular matrix (ECM) degeneration in a mouse aortic dissection (AD) model. MATERIAL AND METHODS Twenty-four 8-month-old C57BL/6J mice were divided into three groups and studied for two weeks: 1) the aortic dissection (AD) Model group (N=8) underwent intraperitoneal injection of angiotensin II (Ang II) (5 ml/kg) three times every 24 h; 2) the mercaptoethanol Treated group (N=8) were given oral mercaptoethanol (2...
March 28, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29545421/autopsy-case-of-aortic-dissection-after-transcatheter-aortic-valve-implantation-tavi
#13
Tereza Losmanova, Ivo Tosoni, Stella Fahrni, Peter Ernst Ballmer
Aortic dissection is one of the severe but rare vascular complications arising from transcatheter aortic valve implantation (TAVI). This paper presents an autopsy case of an 81-year-old male patient with delayed aortic dissection with underlying haemorrhages and acute inflammation 3 years after TAVI.
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29523595/interleukin-3-stimulates-matrix-metalloproteinase-12-production-from-macrophages-promoting-thoracic-aortic-aneurysm-dissection
#14
Chang Liu, Congcong Zhang, Lixin Jia, Boya Chen, Luxin Liu, Jie Sun, Wenmei Zhang, Bin You, Yulin Li, Ping Li, Jie Du
Thoracic aortic aneurysm and dissection (TAAD) is due to degeneration of the aorta and causes a high mortality rate, while molecular mechanisms for the development of TAAD are still not completely understood. In the present study, 3-aminopropionitrile (BAPN) treatment was used to induce TAAD mouse model. Through transcriptome analysis, we found the expression levels of genes associated with interleukin-3 (IL-3) signaling pathway were up-regulated during TAAD development in mouse, which were validated by real-time PCR...
March 30, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29519940/cd40l-deficiency-protects-against-aneurysm-formation
#15
Pascal J H Kusters, Tom T P Seijkens, Linda Beckers, Dirk Lievens, Holger Winkels, Vivian de Waard, Adriaan Duijvestijn, Moritz Lindquist Liljeqvist, Joy Roy, Alan Daugherty, Andrew Newby, Norbert Gerdes, Esther Lutgens
OBJECTIVE: The mechanisms underlying formation of arterial aneurysms remain incompletely understood. Because inflammation is a common feature during the progressive degeneration of the aortic wall, we studied the role of the costimulatory molecule CD40L, a major driver of inflammation, in aneurysm formation. APPROACH AND RESULTS: Transcriptomics data obtained from human abdominal aortic aneurysms and normal aortas revealed increased abundance of both CD40L and CD40 in media of thrombus-free and thrombus-covered human abdominal aortic aneurysms samples...
May 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29514135/cd40l-promotes-development-of-acute-aortic-dissection-via-induction-of-inflammation-and-impairment-of-endothelial-cell-function
#16
Lu Han, Lu Dai, Yuan-Fei Zhao, Hai-Yang Li, Ou Liu, Feng Lan, Wen-Jian Jiang, Hong-Jia Zhang
Acute aortic dissection is one of the most lethal cardiovascular disease. The major histopathological feature of AAD is medial degradation, especially breakdown of elastin and collagen. However, the underlying mechanism remains a mystery. Platelets expressed CD40 Ligand (CD40L) is recently recognised as a key effector of cardiovascular disease development through its pro-inflammatory effect. To clarify the role of CD40L in AAD, we examined level of CD40L in human blood serum samples and found that it is significantly higher in AAD patients compared with healthy subjects (26...
March 4, 2018: Aging
https://www.readbyqxmd.com/read/29473501/a-novel-finding-macrophages-involved-in-inflammation-participate-in-acute-aortic-dissection-complicated-with-acute-lung-injury
#17
Z Wu, Z Wang, P Xu, M Zhang, L Cheng, B Gong
BACKGROUND: Little is known about the pathogenesis of acute lung injury (ALI) complicated with acute aortic dissection (AAD). OBJECTIVE: We aim to investigate the roles of macrophages-derived matrix metalloproteinase 9 (MMP9) in the development of ALI complicated with AAD and factors involved in the recruitment of macrophages. METHODS: This study included three parts: (i) Determination of serum MMPs, angiotensin II (AngII) and MCP-1 in patients with AAD complicated with ALI or AAD only, non-ruptured chronic aortic aneurysm patients or healthy volunteers using ELISA method...
2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29118111/differential-cell-matrix-mechanoadaptations-and-inflammation-drive-regional-propensities-to-aortic-fibrosis-aneurysm-or-dissection-in-hypertension
#18
M R Bersi, R Khosravi, A J Wujciak, D G Harrison, J D Humphrey
The embryonic lineage of intramural cells, microstructural organization of the extracellular matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of the aorta. Yet, it remains unclear why certain diseases manifest differentially along the aorta. Toward this end, myriad animal models provide insight into diverse disease conditions-including fibrosis, aneurysm and dissection-but inherent differences across models impede general interpretations. We examined region-specific cellular, matrix, and biomechanical changes in a single experimental model of hypertension and atherosclerosis, which commonly coexist...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29115411/transcriptome-sequencing-revealed-candidate-genes-relevant-to-mesenchymal-stem-cells-role-in-aortic-dissection-patients
#19
Junlin Yang, Sili Zou, Mingfang Liao, Lefeng Qu
Aortic dissection (AD) results from the imbalance between synthesis and degradation of extracellular matrices in aortic wall, which is characterized by chronic inflammation. Mesenchymal stem cells (MSCs) are known for anti‑inflammatory and repairing effects and have therefore been studied for treatment for numerous diseases, including AD. However, it is unclear which genes or signaling pathways contribute to MSCs' role in AD. In the present study, RNA sequencing (RNA‑seq) was conducted between MSCs from patients with AS (AD‑MSCs) and those from age‑matched healthy donors (HD‑MSCs)...
January 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29108310/significance-of-the-thrombo-inflammatory-status-based-novel-prognostic-score-as-a-useful-predictor-for-in-hospital-mortality-of-patients-with-type-b-acute-aortic-dissection
#20
Dongze Li, Lei Ye, Jing Yu, Lixia Deng, Lianjing Liang, Yan Ma, Lei Yi, Zhi Zeng, Yu Cao, Zhi Wan
Background: Inflammation and thrombosis are associated with development and progression of acute aortic dissection (AAD). The aim of this study was to assess the prognostic significance of Simplified Thrombo-Inflammatory Prognostic Score (sTIPS), in patients with early phase type B AAD. Methods: We retrospectively reviewed 491 patients with type B AAD between November 2012 and September 2015. sTIPS was calculated from the white blood cell count (WBC) and mean platelet volume to platelet count (MPV/PC) ratio, at the time of admission...
October 3, 2017: Oncotarget
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