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Jiangfeng Lu, Shiyu Tang, Yanru Wang, Yao Li, Chang Liu, Yingzhen Niu, Pengkai Cao, Fei Wang
This article compares the long-term outcomes of closing-wedge osteotomy (CWO) and opening-wedge osteotomy (OWO) in the treatment of unicompartmental medial osteoarthritis with varus deformity. This study included 79 patients who underwent high tibial osteotomy (HTO) between 2002 and 2008. Pre- and postoperative radiography and computed tomography were used to evaluate the posterior tibial slope, the patellar height, the tibiofemoral angle, and the lateral and medial tibiofemoral joint space. Pre- and postoperative severity of arthritis was assessed with the Kellgren-Lawrence grading system...
August 13, 2018: Journal of Knee Surgery
Kristen M Kennedy, Chris M Foster, Karen M Rodrigue
Recent evidence indicates that the relationship between increased beta-amyloid (Aβ) deposition and functional task-activation can be characterized by a non-linear trajectory of change in functional activation (Foster et al., 2017), explaining mixed results in prior literature showing both increases and decreases in activation as a function of beta-amyloid burden in cognitively normal adults. Here we sought to replicate this nonlinear effect in the same sample using a different functional paradigm to test the generalizability of this phenomenon...
August 10, 2018: NeuroImage
Janina Golob Deeb, Sompop Bencharit, Christopher A Loschiavo, Matthew Yeung, Daniel Laskin, George R Deeb
PURPOSE: A major advantage of guided implant surgery using 3-dimensionally printed guides is the ability to perform accurate flapless surgery. A drawback of a flapless technique is the inability to manipulate soft tissue to ensure sufficient gingiva around the implant. The purpose of this study was to determine how often flapless surgery using surgical guides results in less than 2 mm of keratinized tissue surrounding the implant. MATERIALS AND METHODS: This retrospective analysis included 27 maxillary and 27 mandibular implant sites that underwent treatment planning for implant-guided surgery using 3Shape Implant Studio (3Shape, Copenhagen, Denmark)...
July 19, 2018: Journal of Oral and Maxillofacial Surgery
Moon Jong Chang, Jin Hwa Jeong, Chong Bum Chang, Young Jun Kim, Bo-Kyung Seo, Min Kyu Song, Taehoon Kang, Seung-Baik Kang
BACKGROUND: Some patients with recurrent symptomatic instability after primary anterior cruciate ligament (ACL) reconstruction have an extension deficiency (ED). This study 1) compared preoperative clinical conditions between the ED and non-ED groups undergoing revision ACL reconstruction, 2) documented clinical and arthroscopic findings in ACL-reconstructed patients with re-instability and ED, and 3) determined whether the ED could be resolved and whether the clinical results of revision surgery differed between the ED and non-ED groups METHODS: This study included 58 patients who underwent revision ACL reconstruction...
August 13, 2018: Scandinavian Journal of Medicine & Science in Sports
José Ignacio Fernández-Vigo, Alfonso C Marcos, Rafael Agujetas, José María Montanero, Inés Sánchez-Guillén, Julián García-Feijóo, Adrián Pandal-Blanco, José Ángel Fernández-Vigo, Ana Macarro-Merino
PURPOSE: To compare aqueous humour (AH) dynamics in the presence of a precrystalline (Implantable Collamer Lens®; ICL) or iris-fixed (Artiflex®) phakic intraocular lens (PIOL). METHODS: By computational fluid dynamics simulation, AH flow was modelled through a peripheral iridotomy (PI) or central lens hole (both 360 μm) in the presence of an Artiflex or ICL lens, respectively. The impacts of AH flow were then determined in terms of wall shear stress (WSS) produced on the endothelium or crystalline lens...
2018: PloS One
Eijiro Okada, Kenshi Daimon, Hirokazu Fujiwara, Yuji Nishiwaki, Kenya Nojiri, Masahiko Watanabe, Hiroyuki Katoh, Kentaro Shimizu, Hiroko Ishihama, Nobuyuki Fujita, Takashi Tsuji, Masaya Nakamura, Morio Matsumoto, Kota Watanabe
STUDY DESIGN: A 20-year longitudinal study. OBJECTIVE: To evaluate the long-term effect of sagittal alignment of the cervical spine on intervertebral disk degeneration in healthy asymptomatic subjects. SUMMARY OF BACKGROUND DATA: This study continues a previous 10-year longitudinal study to determine whether sagittal alignment affects disk degeneration during normal aging. MATERIALS AND METHODS: We assessed 90 healthy subjects (30 men and 60 women) from among 497 volunteers who underwent magnetic resonance imaging (MRI) and plain radiographs of the cervical spine between 1994 and 1996 (follow-up rate 18...
August 10, 2018: Clinical Spine Surgery
Damla Hanalioğlu, Yasemin Özsürekci, Ayşe Büyükçam, Ayşe Gültekingil-Keser, Özlem Tekşam, Mehmet Ceyhan
Hanalioğlu D, Özsürekci Y, Büyükçam A, Gültekingil-Keser A, Tekşam Ö, Ceyhan M. Acute peripheral facial paralysis following varicella infection: An uncommon complication. Turk J Pediatr 2018; 60: 99-101. Chickenpox is caused by varicella zoster virus (VZV/HHV-3), which is one of the eight human herpes viruses. Although chickenpox has a good prognosis, neurologic complications including encephalitis, acute cerebellar ataxia, myelitis and meningitis may seldom be associated with the disease. Peripheral facial palsy (PFP) is an extremely rare complication in patients with chickenpox...
2018: Turkish Journal of Pediatrics
Stine Hangaard, Henrik Gudbergsen, Cecilie L Daugaard, Henning Bliddal, Janus Damm Nybing, Miika T Nieminen, Victor Casula, Carl-Johan Tiderius, Mikael Boesen
BACKGROUND: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). PURPOSE: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA. STUDY TYPE: Cross-sectional...
August 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
Daniel C Kopala-Sibley, Marilyn Cyr, Megan C Finsaas, Jonathan Orawe, Anna Huang, Nim Tottenham, Daniel N Klein
Seventy-nine 3-year olds and their mothers participated in a laboratory-based task to assess maternal hostility. Mothers also reported their behavioral regulation of their child. Seven years later, functional magnetic resonance imaging data were acquired while viewing emotional faces and completing a reward processing task. Maternal hostility predicted more negative amygdala connectivity during exposure to sad relative to neutral faces with frontal and parietal regions as well as more negative left ventral striatal connectivity during monetary gain relative to loss feedback with the right posterior orbital frontal cortex and right inferior frontal gyrus...
August 13, 2018: Child Development
Jeffrey P Gross, Sean Sachdev, Irene B Helenowski, David Lipps, John P Hayes, Eric D Donnelly, Jonathan B Strauss
PURPOSE: The occurrence of upper extremity lymphedema after regional nodal irradiation (RNI) for breast cancer treatment varies significantly based on patient and treatment factors. The relationship between the radiation therapy (RT) field design and lymphedema risk is not well-characterized. The present study sought to correlate the variations in RT field design with lymphedema outcomes. METHODS AND MATERIALS: Women with stage II-IV breast cancer receiving RNI after breast surgery that included sentinel lymph node biopsy or axillary dissection were identified...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Ben Deverett, Sue Ann Koay, Marlies Oostland, Samuel S-H Wang
To make successful evidence-based decisions, the brain must rapidly and accurately transform sensory inputs into specific goal-directed behaviors. Most experimental work on this subject has focused on forebrain mechanisms. Using a novel evidence-accumulation task for mice, we performed recording and perturbation studies of crus I of the lateral posterior cerebellum, which communicates bidirectionally with numerous forebrain regions. Cerebellar inactivation led to a reduction in the fraction of correct trials...
August 13, 2018: ELife
Tugce Celenk-Koca, Aslihan Ertan Erdinc, Serpil Hazar, Lacey Harris, Jeryl D English, Sercan Akyalcin
OBJECTIVES: To evaluate and compare the dental and skeletal changes with conventional and miniscrew-supported maxillary expansion appliances in adolescents. MATERIALS AND METHODS: Forty patients were divided into two groups, with one group receiving a tooth-borne expander and the other group receiving an expander supported by four miniscrews (bone-borne). Multiplanar coronal and axial slices obtained from cone-beam computed tomography images were used to measure the changes in transverse skeletal widths, buccal bone thickness, tooth inclination, and root length...
August 13, 2018: Angle Orthodontist
Ronak H Jani, Marion A Hughes, Zachary E Ligus, Alexandra Nikas, Raymond F Sekula
BACKGROUND AND PURPOSE: Glossopharyngeal neuralgia causes extreme paroxysmal pain in the posterior pharynx, tonsillar region, base of tongue, or deep ear, that is, the distribution of the glossopharyngeal nerve. Some cases of glossopharyngeal neuralgia are associated with neurovascular conflict, usually by the posterior inferior cerebellar artery. Such symptomatic compression occurs only in proximal, centrally myelinated portions of the glossopharyngeal nerve near the brainstem. Microvascular decompression provides effective and durable pain relief for properly selected patients with medically refractory glossopharyngeal neuralgia...
August 13, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Shoichi Emura
We examined the dorsal lingual surfaces of an adult Chapman's zebra by scanning electron microscopy. The filiform papillae of the lingual apex consisted of a main papilla and smaller secondary papillae. The fungiform papillae were round in shape. The filiform papillae of central region of the lingual body were needle-like in shape. The filiform papillae of posterior region of the lingual body were hair-like in shape. Many grooves were observed on posterolateral regions and the fungiform papillae were observed on the inside of some grooves...
2018: Okajimas Folia Anatomica Japonica
Azusa Shiromaru, Ryuta Kinno, Naohito Ito, Kenjiro Ono
No abstract text is available yet for this article.
August 10, 2018: Internal Medicine
Kyoichi Adachi, Takumi Notsu, Tomoko Mishiro, Mayumi Okada, Eiko Okimoto, Yoshikazu Kinoshita
Aim Esophageal mucosal breaks are considered to occur circumferentially in locations with high exposure to acid. In the present study, we investigated the circumferential localization of esophageal mucosal breaks based on their distance from the esophagogastric junction. Subjects and methods The vertical and circumferential localization of 625 esophageal longitudinal mucosal breaks was examined in 398 patients with mild reflux esophagitis. Results The number of mucosal breaks in which the distal end was located 0-1 cm from the esophagogastric junction was 454, while those in which the distal end was located 1-2, 2-3, and >3 cm from the junction were 125, 28, and 18, respectively...
August 10, 2018: Internal Medicine
Ryosuke Tsumagari, Yasuhito Shirai
Brain can be roughly divided into two parts, cerebrum and cerebellum. Cerebrum controls higher brain functions including memory, emotion and cognition, while cerebellum is important for motor coordination. The only output neuron in cerebellum, Purkinje cell, regulates long term depression (LTD). LTD and morphology of Purkinje cells are important for motor function. So far, disorder of protein kinase C (PKC) α and γ, which are expressed in Purkinje cells, impaired LTD, morphology of Purkinje cells and motor coordination...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Shigeru Tanaka
G-protein-coupled receptor 3 (GPR3) is a member of the class A rhodopsin-type GPCR family and is highly expressed in various neurons. A unique feature of GPR3 is its ability to constitutively activate the Gαs protein without the addition of ligands, which results in the elevation of the basal level of intracellular cAMP. During the development of the cerebellum, GPR3 expression is upregulated in cerebellar granular neurons (CGNs) and maintained thereafter. In our previous studies, we showed that the intrinsic expression of GPR3 in CGNs is highly associated with neurite outgrowth, neurite differentiation, and neuronal survival...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Takefumi Uemura, Naoki Sawada, Takao Sakaba, Satoshi Kametaka, Masaya Yamamoto, Satoshi Waguri
Adaptor protein complex-1 (AP-1) and Golgi associated, γ-adaptin ear containing, Arf binding proteins (GGAs) are clathrin adaptors that regulate membrane trafficking between the trans-Golgi network (TGN) and endosomes. p56 is a clathrin adaptor accessory protein that may modulate the function of GGAs in mammalian cell lines. However, the precise relationship between p56 and the three GGAs (GGA1-3), as well as the physiological role of p56 in tissue cells, remain unknown. To this end, we generated an antibody against p56 and determined its cellular localization...
2018: Biomedical Research
Mustafa C Kir, Semih Ayanoglu, Haluk Cabuk, Suleyman S Dedeoglu, Yunus Imren, Bulent Karslioglu, Ali Yuce, Hakan Gurbuz
OBJECTIVE: Intra-articular displaced calcaneal fractures are common fractures and are often treated with surgical interventions. Sinüs tarsi approach provides secure access to lateral wall and joint facets. The aim of the study is to compare cannulated screw (CS) fixation and mini-plate (MP) fixation via sinus tarsi approach with Sanders types 2 and 3 fracture of calcaneus. METHODS: Sixty patients with Sanders types 2 and 3 calcaneal fracture underwent surgical intervention were randomly allocated into two groups as group MP fixation and group CS fixation regarding osteosynthesis method for 5-year period...
May 2018: Journal of Orthopaedic Surgery
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