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https://www.readbyqxmd.com/read/27910816/the-stimulatory-effect-of-silica-nanoparticles-on-osteogenic-differentiation-of-human-mesenchymal-stem-cells
#1
Xing Yang, Yuanyuan Li, Xujie Liu, Qianli Huang, Wei He, Ranran Zhang, Qingling Feng, Dafna Benayahu
Silica-based materials with favourable biocompatibility are generally considered as excellent candidates for applications in biomedical fields. However, previous researches mainly focused on the safety of silica-based materials, their effects on osteogenic differentiation of human mesenchymal stem cells (hMSCs) still need further investigations. In this study, core-shell fluorescent silica nanoparticles (silica NPs) with three different sizes (S1 ~ 50 nm, S2 ~ 200 nm, S3 ~ 400 nm, respectively) were prepared according to the Stöber method...
December 2, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27901495/air-pollution-and-dna-methylation-alterations-in-lung-cancer-a-systematic-and-comparative-study
#2
Cheng-Lan Jiang, Shui-Wang He, Yun-Dong Zhang, He-Xian Duan, Tao Huang, Yun-Chao Huang, Gao-Feng Li, Ping Wang, Li-Ju Ma, Guang-Biao Zhou, Yi Cao
The lung cancer incidence in the Xuanwei and neighboring region, Yunnan, China, is among the highest in China and is attributed to severe air pollution with high benzo(a)pyrene levels. We systematically and comparatively analyzed DNA methylation alterations at genome and gene levels in Xuanwei lung cancer tissues and cell lines, as well as benzo(a)pyrene-treated cells and mouse samples. We obtained a comprehensive dataset of genome-wide cytosine-phosphate-guanine island methylation in air pollution-related lung cancer samples...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27896428/xci-escaping-gene-kdm5c-contributes-to-ovarian-development-via-downregulating-mir-320a
#3
Yi-Xi Sun, Yi-Xin Zhang, Dan Zhang, Chen-Ming Xu, Song-Chang Chen, Jun-Yu Zhang, Ye-Chun Ruan, Feng Chen, Run-Ju Zhang, Ye-Qing Qian, Yi-Feng Liu, Lu-Yang Jin, Tian-Tian Yu, Hai-Yan Xu, Yu-Qin Luo, Xin-Mei Liu, Fei Sun, Jian-Zhong Sheng, He-Feng Huang
Mechanisms underlying female gonadal dysgenesis remain unclarified and relatively unstudied. Whether X-chromosome inactivation (XCI)-escaping genes and microRNAs (miRNAs) contribute to this condition is currently unknown. We compared 45,X Turner Syndrome women with 46,XX normal women, and investigated differentially expressed miRNAs in Turner Syndrome through plasma miRNA sequencing. We found that miR-320a was consistently upregulated not only in 45,X plasma and peripheral blood mononuclear cells (PBMCs), but also in 45,X fetal gonadal tissues...
November 28, 2016: Human Genetics
https://www.readbyqxmd.com/read/27894382/-study-of-tumor-necrosis-factor-%C3%AE-induced-protein-8-like-2-expression-in-peripheral-blood-mononuclear-cells-of-patients-with-acute-respiratory-distress-syndrome-correlate-with-disease-severity
#4
He Huang, Cong Feng, Zhaotao Tian, Yongming Yao, Tanshi Li
OBJECTIVE: To demonstrate the effect of tumor necrosis factor-α induced protein 8 like-2 (TIPE2) expression in patients with acute respiratory distress syndrome (ARDS) and its mechanism. METHODS: A prospective observation was conducted. Thirty-nine patients with ARDS admitted to department of emergency of PLA General Hospital from July 2013 to July 2015 were enrolled, and 35 healthy persons served as control group. The acute physiology and chronic health evaluation II (APACHE II) score within 24 hours after admission, blood gas analysis, procalcitonin (PCT), and C-reactive protein (CRP) were recorded...
June 2016: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/27888796/altered-dna-methylation-in-neonates-born-large-for-gestational-age-is-associated-with-cardiometabolic-risk-in-children
#5
Xian-Hua Lin, Dan-Dan Wu, Ling Gao, Jun-Yu Zhang, Hai-Tao Pan, Hui Wang, Cheng Li, Ping Zhang, Meng-Xi Guo, Yan-Ting Wu, Ya-Jing Tan, Li Jin, Yu-Qian Xiang, Ju-Xue Li, Jian-Zhong Sheng, He-Feng Huang
BACKGROUND: Infants being born Large-for-gestational-age (LGA) are prone to developing cardiometabolic disease. However, the underlying mechanisms remain unclear. RESULTS: Clinical investigation showed that children born LGA had significantly higher serum level of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and insulin, ratio of TC/high-density lipoprotein-cholesterol (HDL-c) compared to children born appropriate for gestational age (AGA)...
November 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27853643/peritumoral-stromal-neutrophils-are-essential-for-c-met-elicited-metastasis-in-human-hepatocellular-carcinoma
#6
Min He, Anping Peng, Xian-Zhang Huang, Dai-Chao Shi, Jun-Cheng Wang, Qiyi Zhao, Haibiao Lin, Dong-Ming Kuang, Pei-Feng Ke, Xiang-Ming Lao
Inflammation is a component of tumor progression mechanisms. Neutrophils are a common inflammatory infiltrate in many tumors, but their regulation and functions in neoplasia are not understood. Here, we showed, in detailed studies of c-Met molecule in 225 untreated patients with hepatocellular carcinoma (HCC), that high infiltration of neutrophils in HCC tissues determined malignant cell c-Met-associated clinical outcome of patients. High infiltration of neutrophils in HCCs determined malignant cell c-Met-associated clinical outcome of patients...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27852049/a-nomogram-to-predict-the-probability-of-axillary-lymph-node-metastasis-in-female-patients-with-breast-cancer-in-china-a-nationwide-multicenter-10-year-epidemiological-study
#7
Jian Zhang, Xiao Li, Rong Huang, Wei-Liang Feng, Ya-Nan Kong, Feng Xu, Lin Zhao, Qing-Kun Song, Jing Li, Bao-Ning Zhang, Jin-Hu Fan, You-Lin Qiao, Xiao-Ming Xie, Shan Zheng, Jian-Jun He, Ke Wang
Axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB) alone may lead to postoperative complications. Among patients with positive ALN in the preoperative examination, approximately 40% patients do not have SLN metastasis. Herein, we aimed to develop a model to predict the probability of ALN metastasis as a preoperative tool to support clinical decision-making. We retrospectively analyzed the clinicopathological features of 4211 female patients with breast cancer who were diagnosed in seven breast cancer centers representing entire China, over 10 years (1999-2008)...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27827435/maternal-high-estradiol-exposure-is-associated-with-elevated-thyroxine-and-pax8-in-mouse-offspring
#8
Ping-Ping Lv, Shen Tian, Chun Feng, Jing-Yi Li, Dan-Qin Yu, Li Jin, Yan Shen, Tian-Tian Yu, Ye Meng, Guo-Lian Ding, Min Jin, Xi-Jing Chen, Jian-Zhong Sheng, Dan Zhang, He-Feng Huang
Our previous studies have shown that maternal high estradiol (E2) environment increased the risk of thyroid dysfunction in offspring. However, the mechanism involved remains unexplored. To evaluate the thyroid function of offspring after high E2 exposure and to explore the underlying mechanism, we established a high E2 mouse model of early pregnancy, and detected thyroid hormones of their offspring. In thyroids of offspring, the expressions of Tg, Nis, Tpo, Pax8, and Titf1 and CpG island methylation status of Pax8 and genes involved in methylation were analyzed...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27826040/dying-glioma-cells-establish-a-proangiogenic-microenvironment-through-a-caspase-3-dependent-mechanism
#9
Xiao Feng, Yang Yu, Sijia He, Jin Cheng, Yanping Gong, Zhengxiang Zhang, Xuguang Yang, Bing Xu, Xinjian Liu, Chuan-Yuan Li, Ling Tian, Qian Huang
Vascular recovery or re-angiogenesis after radiotherapy plays a significant role in tumor recurrence, whereas molecular mechanisms of this process remain elusive. In this work, we found that dying glioma cells promoted post-irradiation angiogenesis through a caspase 3 dependent mechanism. Evidence in vitro and in vivo indicated that caspase 3 inhibition undermined proangiogenic effects of dying glioma cells. Proteolytic inactivation of caspase 3 in glioma cells reduced tumorigenicity. Importantly, we identified that NF-κB/COX-2/PGE2 axis acted as downstream signaling of caspase 3, mediating proangiogenic response after irradiation...
November 5, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27825649/sources-atmospheric-transport-and-deposition-mechanism-of-organochlorine-pesticides-in-soils-of-the-tibetan-plateau
#10
Laiguo Chen, Qianhua Feng, Qiusheng He, Yumei Huang, Yu Zhang, Guo Jiang, Wei Zhao, Bo Gao, Kui Lin, Zhencheng Xu
Because of mountain cold-trapping, the soil in the Tibetan Plateau may be an important global sink of organochlorine pesticides (OCPs). However, there are limited data on OCPs in the soils of the Tibetan Plateau. In addition, the atmospheric transport and deposition mechanisms of OCPs also need to be further studied. In this study, the sampling area covered most regions of the Tibetan Plateau. The detection frequencies of ΣChlordane (sum of trans-chlordane, cis-chlordane and oxychlordane), HCB, ΣNonachlor (sum of trans- and cis-nonachlor), DDTs, ΣEndo (sum of endosulfan-I, endosulfan-II and endosulfate), aldrin, HCHs, ΣHeptachlor (sum of heptachlor and heptachlor epoxide), mirex and dieldrin were 100%, 98...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27822364/new-withanolides-with-trail-sensitizing-effect-from-physalis-pubescens-l
#11
Li-Xia Chen, Gui-Yang Xia, Hao He, Jian Huang, Feng Qiu, Xiao-Lin Zi
Physalis pubescens L. plant produces nutritious and healthy fruits, called husk tomato or hairy ground cherry. However, its bioactive components are largely unknown. Four new withanolide steroids (1-4) together with one known withanolide (5) were isolated from the extract of P. pubescens L. and their chemical structures were established by extensive spectroscopic analyses. Compounds 1, 3 and 5 showed potent growth inhibitory effects against four human renal cell carcinoma (RCC) cell lines (i.e. 786-O, A-498, Caki-2 and ACHN)...
2016: RSC Advances
https://www.readbyqxmd.com/read/27818927/simultaneous-quantification-of-ginsenoside-rg1-and-its-metabolites-by-hplc-ms-ms-rg1-excretion-in-rat-bile-urine-and-feces
#12
Chiyu He, Ru Feng, Yupeng Sun, Shifeng Chu, Ji Chen, Chao Ma, Jie Fu, Zhenxiong Zhao, Min Huang, Jiawen Shou, Xiaoyang Li, Yuzhu Wang, Jinfeng Hu, Yan Wang, Juntian Zhang
Ginsenoside Rg1 (Rg1), the major effective component of ginseng, has been shown to have multiple bioactivities, but low oral bioavailability. The aim of this study was to develop a simple, sensitive and rapid high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, which could be used to validate and quantify the concentrations of Rg1 and its metabolites in Sprague-Dawley rat bile, urine, and feces after oral administration (25 mg/kg). Calibration curves offered satisfactory linearity (r>0...
November 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27811093/draft-genome-sequence-of-the-bacterium-comamonas-aquatica-cjg
#13
Wenkui Dai, Yutong Zhu, Xiqian Wang, Nazgul Sakenova, Zhenyu Yang, Hongjuan Wang, Guoqiao Li, Jiajing He, Deyu Huang, Yongfei Cai, Weizheng Guo, Qian Wang, Tingting Feng, Quanshui Fan, Tianling Zheng, Aidong Han
A Gram-negative bacterial strain, Comamonas aquatica CJG, absorbs low-density lipoprotein but not high-density lipoprotein in serum. Here, we report its draft genomic sequence of 3,764,434 bp, containing total 3,425 genes, 27% of which encode proteins for metabolism and energy conversion, and it is 30% identical to the genome of Comamonas testosteroni.
November 3, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27810403/mirna-194-activates-the-wnt-%C3%AE-catenin-signaling-pathway-in-gastric-cancer-by-targeting-the-negative-wnt-regulator-sufu
#14
Yin Peng, Xiaojing Zhang, Qiang Ma, Ruibin Yan, Ying Qin, Yanqiu Zhao, Yulan Cheng, Mengting Yang, Qixiang Wang, Xianling Feng, Yong Huang, Weiling Huang, Zhenfu Zhao, Liang Wang, Yanjie Wei, Zhendan He, Xinmin Fan, Song Li, Zhe Jin, Stephen J Meltzer
Emerging evidence has shown that miRNA-194 is aberrantly upregulated in gastric cancer (GC); however, the biological mechanisms underlying its involvement are largely unknown. Wnt/β-catenin signaling has been implicated in gastric tumorigenesis; we therefore hypothesized that miRNA-194 promotes gastric carcinogenesis by activating Wnt/β-catenin signaling. MiRNA-194 was found to be overexpressed in GC cell lines and 43 paired GC tissues. Overexpression of miRNA-194 promoted cell proliferation and migration, while inhibition of miRNA-194 blocked these processes...
October 31, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27805691/high-order-optical-vortex-generation-in-a-few-mode-fiber-via-cascaded-acoustically-driven-vector-mode-conversion
#15
Wending Zhang, Ligang Huang, Keyan Wei, Peng Li, Biqiang Jiang, Dong Mao, Feng Gao, Ting Mei, Guoquan Zhang, Jianlin Zhao
We propose a method to generate the high-order optical vortex in a few-mode fiber via cascaded acoustically driven vector mode conversion. Theoretical analysis showed that the vector mode conversion induced by the acoustically induced fiber grating (AIFG) could occur between two HE modes with adjacent azimuthal numbers. In the experiment conducted at 532 nm, two AIFGs were simultaneously induced in the same segment of the fiber by a radio frequency source containing two different frequency components. One AIFG was used to convert the left- and right-handed circular polarization fundamental modes to the ±1-order vortex modes, which were then further converted to the ±2-order vortex modes by the other AIFG...
November 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27791169/allelic-diversity-in-an-nlr-gene-bph9-enables-rice-to-combat-planthopper-variation
#16
Yan Zhao, Jin Huang, Zhizheng Wang, Shengli Jing, Yang Wang, Yidan Ouyang, Baodong Cai, Xiu-Fang Xin, Xin Liu, Chunxiao Zhang, Yufang Pan, Rui Ma, Qiaofeng Li, Weihua Jiang, Ya Zeng, Xinxin Shangguan, Huiying Wang, Bo Du, Lili Zhu, Xun Xu, Yu-Qi Feng, Sheng Yang He, Rongzhi Chen, Qifa Zhang, Guangcun He
Brown planthopper (BPH), Nilaparvata lugens Stål, is one of the most devastating insect pests of rice (Oryza sativa L.). Currently, 30 BPH-resistance genes have been genetically defined, most of which are clustered on specific chromosome regions. Here, we describe molecular cloning and characterization of a BPH-resistance gene, BPH9, mapped on the long arm of rice chromosome 12 (12L). BPH9 encodes a rare type of nucleotide-binding and leucine-rich repeat (NLR)-containing protein that localizes to the endomembrane system and causes a cell death phenotype...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27789776/chemotherapy-near-the-end-of-life-for-chinese-patients-with-solid-malignancies
#17
Jin Sheng, Ya-Xiong Zhang, Xiao-Bo He, Wen-Feng Fang, Yun-Peng Yang, Gui-Nan Lin, Xuan Wu, Ning Li, Jing Zhang, Lin-Zhu Zhai, Yuan-Yuan Zhao, Yan Huang, Ning-Ning Zhou, Hong-Yun Zhao, Li Zhang
INTRODUCTION: There are increasing concerns about the negative impacts of chemotherapy near the end of life (EOL). There is discrepancy among different countries about its use, and little is known about the real-world situation in China. PATIENTS AND METHODS: This retrospective study was conducted at six representative hospitals across China. Adult decedents with a record of advanced solid cancer and palliative chemotherapy were consecutively screened from 2010 through 2014...
October 27, 2016: Oncologist
https://www.readbyqxmd.com/read/27787238/automatic-crystal-centring-procedure-at-the-ssrf-macromolecular-crystallography-beamline
#18
Zhijun Wang, Qiangyan Pan, Lifeng Yang, Huan Zhou, Chunyan Xu, Feng Yu, Qisheng Wang, Sheng Huang, Jianhua He
X-ray diffraction is a common technique for determining crystal structures. The average time needed for the solution of a protein structure has been drastically reduced by a number of recent experimental and theoretical developments. Since high-throughput protein crystallography benefits from full automation of all steps that are carried out on a synchrotron beamline, an automatic crystal centring procedure is important for crystallographic beamlines. Fully automatic crystal alignment involves the application of optical methods to identify the crystal and move it onto the rotation axis and into the X-ray beam...
November 1, 2016: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/27776551/molecular-characterization-and-multilocus-genotypes-of-enterocytozoon-bieneusi-among-horses-in-southwestern-china
#19
Lei Deng, Wei Li, Zhijun Zhong, Chao Gong, Xuehan Liu, Xiangming Huang, Li Xiao, Ruoxuan Zhao, Wuyou Wang, Fan Feng, Yue Zhang, Yanchun Hu, Hualin Fu, Min He, Yue Zhang, Kongju Wu, Guangneng Peng
BACKGROUND: Enterocytozoon bieneusi is one of the most prevalent causative species of diarrhea and enteric diseases in various hosts. E. bieneusi has been identified in humans, mammals, birds, rodents and reptiles in China, but few studies have reported E. bieneusi in horses. Therefore, the present study was conducted to assess the prevalence, molecular characteristics and zoonotic potential of E. bieneusi among horses in southwestern China. FINDINGS: Three hundred and thirty-three fecal specimens were collected from horses on five farms in the Sichuan and Yunnan provinces of southwestern China...
October 25, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27773765/new-acetylenic-acids-and-derivatives-from-the-basidiomycete-craterellus-lutescens-cantharellaceae
#20
Ying Huang, Shuai-Bing Zhang, He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng, Ji-Kai Liu
Five new acetylenic acid analogues, craterellynes A-E (1-5), together with three known compounds (6-8), were isolated from the fruiting bodies of Craterellus lutescens. Their structures were elucidated on the basis of spectroscopic and chemical means. The absolute configurations of 1-6 were determined by the modified Mosher method.
October 20, 2016: Fitoterapia
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