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Huang he-feng

Sai Ge, Xia Xia, Chen Ding, Bei Zhen, Quan Zhou, Jinwen Feng, Jiajia Yuan, Rui Chen, Yumei Li, Zhongqi Ge, Jiafu Ji, Lianhai Zhang, Jiayuan Wang, Zhongwu Li, Yumei Lai, Ying Hu, Yanyan Li, Yilin Li, Jing Gao, Lin Chen, Jianming Xu, Chunchao Zhang, Sung Yun Jung, Jong Min Choi, Antrix Jain, Mingwei Liu, Lei Song, Wanlin Liu, Gaigai Guo, Tongqing Gong, Yin Huang, Yang Qiu, Wenwen Huang, Tieliu Shi, Weimin Zhu, Yi Wang, Fuchu He, Lin Shen, Jun Qin
The diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with the worst prognosis and few treatment options. Here we present a dataset from 84 DGC patients, composed of a proteome of 11,340 gene products and mutation information of 274 cancer driver genes covering paired tumor and nearby tissue. DGC can be classified into three subtypes (PX1-3) based on the altered proteome alone. PX1 and PX2 exhibit dysregulation in the cell cycle and PX2 features an additional EMT process; PX3 is enriched in immune response proteins, has the worst survival, and is insensitive to chemotherapy...
March 8, 2018: Nature Communications
Mengxuan Xu, Liang Chen, Zhiming Yao, Shuqing Ren, Yuying Zhang, Feng Huang, Xu Ji, Chaohui He, Leidang Zhou, Jing Hu, Shiyi He, Kuo Zhao, Xiaoping Ouyang
A ZnO:Ga single crystal with an applicable size of φ40 × 1 mm was prepared using the hydro-thermal method. The crystal exhibits good crystallinity and scintillation properties with a 63.94-arcsec full-width at half-maximum (FWHM) in the X-ray rocking curve (XRC) spectrum, 8% luminous non-uniformity, emission at 389 nm in the X-ray excited luminescence spectrum, fast response and 5.5% BGO luminous intensity. Furthermore, an X-ray pinhole imaging system of nanosecond temporal resolution with a ZnO:Ga single-crystal image converter was established to diagnose the cathode electron emission spatial distribution of an intense current diode...
March 8, 2018: Scientific Reports
Chen Wang, Qiyuan He, Udayabagya Halim, Yuanyue Liu, Enbo Zhu, Zhaoyang Lin, Hai Xiao, Xidong Duan, Ziying Feng, Rui Cheng, Nathan O Weiss, Guojun Ye, Yun-Chiao Huang, Hao Wu, Hung-Chieh Cheng, Imran Shakir, Lei Liao, Xianhui Chen, William A Goddard Iii, Yu Huang, Xiangfeng Duan
Artificial superlattices, based on van der Waals heterostructures of two-dimensional atomic crystals such as graphene or molybdenum disulfide, offer technological opportunities beyond the reach of existing materials. Typical strategies for creating such artificial superlattices rely on arduous layer-by-layer exfoliation and restacking, with limited yield and reproducibility. The bottom-up approach of using chemical-vapour deposition produces high-quality heterostructures but becomes increasingly difficult for high-order superlattices...
March 7, 2018: Nature
Qiang Wang, Jian Mo, Chenchen Zhao, Kangmao Huang, Mingxuan Feng, Wenxin He, Jiying Wang, Shuai Chen, Zi'ang Xie, Jianjun Ma, Shunwu Fan
Bone metastasis is a severe complication of advanced breast cancer, resulting in osteolysis and increased mortality in patients. Raddeanin A (RA), isolated from traditional Chinese herbs, is an oleanane-type triterpenoid saponin with anticancer potential. In this study, we investigated the effects of RA in breast cancer-induced osteolysis and elucidated the possible mechanisms involved in this process. We first verified that RA could suppress osteoclast formation and bone resorption in vitro. Next, we confirmed that RA suppressed Ti-particle-induced osteolysis in a mouse calvarial model, possibly through inhibition of the SRC/AKT signaling pathway...
March 7, 2018: Cell Death & Disease
Zhongpei Feng, Jie Yuan, Ge He, Wei Hu, Zefeng Lin, Dong Li, Xingyu Jiang, Yulong Huang, Shunli Ni, Jun Li, Beiyi Zhu, Xiaoli Dong, Fang Zhou, Huabing Wang, Zhongxian Zhao, Kui Jin
Stabilized FeSe thin films in ambient pressure with tunable superconducting critical temperature would be a promising candidate for superconducting electronic devices. By carefully controlling the depositions on twelve kinds of substrates using a pulsed laser deposition technique single crystalline FeSe thin films were fabricated. The high quality of the thin films was confirmed by X-ray diffraction with a full width at half maximum of 0.515° in the rocking curve and clear four-fold symmetry in φ-scan. The films have a maximum Tc ~ 15 K on the CaF2 substrate and were stable in ambient conditions air for more than half a year...
March 6, 2018: Scientific Reports
Bao-Feng Jin, Fan Yang, Xiao-Min Ying, Lin Gong, Shuo-Feng Hu, Qing Zhao, Yi-Da Liao, Ke-Zhong Chen, Teng Li, Yan-Hong Tai, Yuan Cao, Xiao Li, Yan Huang, Xiao-Yan Zhan, Xuan-He Qin, Jin Wu, Shuai Chen, Sai-Sai Guo, Yu-Cheng Zhang, Jing Chen, Dan-Hua Shen, Kun-Kun Sun, Lu Chen, Wei-Hua Li, Ai-Ling Li, Na Wang, Qing Xia, Jun Wang, Tao Zhou
BACKGROUND: Non-small-cell lung cancer (NSCLC) is characterized by abnormalities of numerous signaling proteins that play pivotal roles in cancer development and progression. Many of these proteins have been reported to be correlated with clinical outcomes of NSCLC. However, none of them could provide adequate accuracy of prognosis prediction in clinical application. METHODS: A total of 384 resected NSCLC specimens from two hospitals in Beijing (BJ) and Chongqing (CQ) were collected...
March 6, 2018: BMC Cancer
He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Ying Huang, Shuai-Bing Zhang, Yang Tang, Jian-Neng Yao, Lin Chen, Masahiko Isaka, Tao Feng, Ji-Kai Liu
This study features the isolation and identification of twelve lanostane-type triterpenoids, namely lepiotaprocerins A-L (1-12), from the fruiting bodies of Poland-collected edible mushroom Macrolepiota procera. Their structures as well as absolute configurations were ambiguously established by extensive spectroscopic analyses, ECD calculation, and single crystal X-ray diffraction analyses. Structurally, lepiotaprocerins A-F (1-6) are distinguished by the presence of a rare "1-en-1,11-epoxy" moiety which have not been previously described in the lanostane class...
March 6, 2018: Journal of Agricultural and Food Chemistry
Chengliang Zhou, Ying Yu, Qian Yang, Huihui Wang, Min Hou, Li Jin, Fanghong Zhang, Jiangzhong Sheng, Mingfang Miao, Xiaofu Yang, He-Feng Huang
Telbivudine is an orally nucleoside analog with potent and specific antihepatitis B virus (HBV) activity, and it has been reported to block mother-to-infant transmission. However, few studies have focused on the safety of prenatal exposure for offspring development.This is a prospective noninterventional study. Participants were enrolled during delivery through the Women's Hospital of Zhejiang University School of Medicine between January 2012 and September 2013. Neonate's umbilical cord arterial blood (UCAB) was collected after delivery...
March 2018: Medicine (Baltimore)
Yajuan Huang, Haishen Wen, Meizhao Zhang, Nan Hu, Yufeng Si, Siping Li, Feng He
Many genes related to muscle growth determine the proliferation of myoblasts, initiate myoblast differentiation and muscle hypertrophy. MyoD is a myogenic determination factor and contributes to myoblast determination, and IGF-I regulates muscle hypertrophy and muscle mass. MyoD interacted with IGF-I in regulating muscle hypertrophy and muscle mass. The aim of our study was to assess DNA methylation and mRNA expression patterns of MyoD and IGF-I during different developmental stages of Japanese flounder, and to examine the relationship between MyoD and IGF-I gene...
February 24, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Lulu Liu, Xiaoling Wan, Peipei Zhou, Xiaoyuan Zhou, Wei Zhang, Xinhui Hui, Xiujie Yuan, Xiaodan Ding, Ruihong Zhu, Guangxun Meng, Hui Xiao, Feng Ma, He Huang, Xianmin Song, Bin Zhou, Sidong Xiong, Yan Zhang
BACKGROUND: Adenosine triphosphate (ATP)-dependent chromatin remodeling SWI/SNF-like BAF and PBAF complexes have been implicated in the regulation of stem cell function and cancers. Several subunits of BAF or PBAF, including BRG1, BAF53a, BAF45a, BAF180, and BAF250a, are known to be involved in hematopoiesis. Baf200, a subunit of PBAF complex, plays a pivotal role in heart morphogenesis and coronary artery angiogenesis. However, little is known on the importance of Baf200 in normal and malignant hematopoiesis...
February 26, 2018: Journal of Hematology & Oncology
Y T Luo, J Cheng, X Feng, S J He, Y W Wang, Q Huang
With cancer stem cells (CSCs) became the research hotspot, emerging studies attempt to reveal the functions of these special subsets in tumorigenesis. Although various approaches have been used in CSCs researches, only a few could really reflect or simulate the microenvironment in vivo. At present, CSCs theories are still difficult to apply for clinical remedy because CSCs subpopulations are always hard to identify and trace. Thus an ideal approach for clinicians and researchers is urgently needed. Circulating tumor cells (CTCs), as the method of noninvasive-liquid biopsy, could be detected in the peripheral blood (PB) from many tumors and even could be treated as procurators for CSCs deeper researches from patient-derived sample...
February 26, 2018: Journal of Experimental & Clinical Cancer Research: CR
L Adamczyk, J R Adams, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, N N Ajitanand, I Alekseev, D M Anderson, R Aoyama, A Aparin, D Arkhipkin, E C Aschenauer, M U Ashraf, A Attri, G S Averichev, X Bai, V Bairathi, K Barish, A Behera, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, J D Brandenburg, A V Brandin, D Brown, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, I Chakaberia, P Chaloupka, Z Chang, N Chankova-Bunzarova, A Chatterjee, S Chattopadhyay, X Chen, J H Chen, X Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, T G Dedovich, J Deng, A A Derevschikov, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, L E Dunkelberger, J C Dunlop, L G Efimov, N Elsey, J Engelage, G Eppley, R Esha, S Esumi, O Evdokimov, J Ewigleben, O Eyser, R Fatemi, S Fazio, P Federic, P Federicova, J Fedorisin, Z Feng, P Filip, E Finch, Y Fisyak, C E Flores, J Fujita, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, D Grosnick, D S Gunarathne, Y Guo, A Gupta, S Gupta, W Guryn, A I Hamad, A Hamed, A Harlenderova, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, S Horvat, X Huang, B Huang, T Huang, H Z Huang, T J Humanic, P Huo, G Igo, W W Jacobs, A Jentsch, J Jia, K Jiang, S Jowzaee, E G Judd, S Kabana, D Kalinkin, K Kang, D Kapukchyan, K Kauder, H W Ke, D Keane, A Kechechyan, Z Khan, D P Kikoła, C Kim, I Kisel, A Kisiel, L Kochenda, M Kocmanek, T Kollegger, L K Kosarzewski, A F Kraishan, L Krauth, P Kravtsov, K Krueger, N Kulathunga, L Kumar, J Kvapil, J H Kwasizur, R Lacey, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, C Li, X Li, Y Li, W Li, J Lidrych, T Lin, M A Lisa, P Liu, H Liu, Y Liu, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, S Luo, X Luo, Y G Ma, L Ma, R Ma, G L Ma, N Magdy, R Majka, D Mallick, S Margetis, C Markert, H S Matis, K Meehan, J C Mei, Z W Miller, N G Minaev, S Mioduszewski, D Mishra, S Mizuno, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, Md Nasim, T K Nayak, J M Nelson, M Nie, G Nigmatkulov, T Niida, L V Nogach, T Nonaka, S B Nurushev, G Odyniec, A Ogawa, K Oh, V A Okorokov, D Olvitt, B S Page, R Pak, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, P Pile, J Pluta, K Poniatowska, J Porter, M Posik, N K Pruthi, M Przybycien, J Putschke, H Qiu, A Quintero, S Ramachandran, R L Ray, R Reed, M J Rehbein, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, J D Roth, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, S Salur, J Sandweiss, M Saur, J Schambach, A M Schmah, W B Schmidke, N Schmitz, B R Schweid, J Seger, M Sergeeva, R Seto, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, A Sharma, M K Sharma, W Q Shen, S S Shi, Z Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, N Smirnov, D Smirnov, W Solyst, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Strikhanov, B Stringfellow, A A P Suaide, T Sugiura, M Sumbera, B Summa, Y Sun, X M Sun, X Sun, B Surrow, D N Svirida, Z Tang, A H Tang, A Taranenko, T Tarnowsky, A Tawfik, J Thäder, J H Thomas, A R Timmins, D Tlusty, T Todoroki, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, B A Trzeciak, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, A N Vasiliev, F Videbæk, S Vokal, S A Voloshin, A Vossen, G Wang, Y Wang, F Wang, Y Wang, J C Webb, G Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y Wu, Z G Xiao, G Xie, W Xie, J Xu, Z Xu, Q H Xu, Y F Xu, N Xu, S Yang, Y Yang, C Yang, Q Yang, Z Ye, Z Ye, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, Z Zhang, J B Zhang, J Zhang, S Zhang, Y Zhang, X P Zhang, J Zhang, S Zhang, J Zhao, C Zhong, C Zhou, L Zhou, X Zhu, Z Zhu, M Zyzak
Rapidity-odd directed-flow measurements at midrapidity are presented for Λ, Λ[over ¯], K^{±}, K_{s}^{0}, and ϕ at sqrt[s_{NN}]=7.7, 11.5, 14.5, 19.6, 27, 39, 62.4, and 200 GeV in Au+Au collisions recorded by the Solenoidal Tracker detector at the Relativistic Heavy Ion Collider. These measurements greatly expand the scope of data available to constrain models with differing prescriptions for the equation of state of quantum chromodynamics. Results show good sensitivity for testing a picture where flow is assumed to be imposed before hadron formation and the observed particles are assumed to form via coalescence of constituent quarks...
February 9, 2018: Physical Review Letters
Shaoqing Cao, Yu Shao, Ying Wang, Tiesheng Wu, Longfei Zhang, Yijian Huang, Feng Zhang, Changrui Liao, Jun He, Yiping Wang
A highly sensitive refractive index sensor based on surface plasmon resonance in a side-polished low-index polymer optical fiber is proposed for biosensing. Benefitting from the low refractive index of the fiber core, the sensitivity of the device can reach ~44567 nm/RIU theoretically for aqueous solutions, at the expense of a lowered upper detection limit that is down to ~1.340. The sensor is fabricated by coating 55-nm-thick Au-film on the polished surface of a graded-index perfluorinated polymer optical fiber...
February 19, 2018: Optics Express
Yan-Sheng Huang, Ding-Jun Hao, Hang Feng, Hai-Ping Zhang, Si-Min He, Chao-Yuan Ge, Xing-Bang Niu
BACKGROUND The purpose of this study was to compare the efficacy of percutaneous kyphoplasty (PKP) and bone cement-augmented short segmental fixation (BCA+SSF) for treating Kümmell disease. MATERIAL AND METHODS Between June 2013 and December 2015, 60 patients were treated with PKP or BCA+SSF. All patients were followed up for 12-36 months. We retrospectively reviewed outcomes, including Oswestry Disability Index (ODI), visual analogue scale (VAS), and kyphotic Cobb angle. RESULTS VAS, ODI, and Cobb angle, measured postoperatively and at the final follow-up, were lower than those measured preoperatively in both groups (P<0...
February 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Ying Shen, Yuandong Feng, Hongli Chen, Lingjuan Huang, Fangxia Wang, Ju Bai, Yun Yang, Jianli Wang, Wanhong Zhao, Yachun Jia, Yan Peng, Xiaoru Lei, Aili He
AIMS: Multiple myeloma (MM) is an incurable hematological cancer with a higher rate of relapse. Alterations in the function of long non-coding RNAs (lncRNAs) promote the progression and metastasis of cancer. We carry out this study to explore the expression profile of differently expressed lncRNAs in newly diagnosed MM. MAIN METHODS: The Bone marrows we analyzed were obtained from five MM and five IDA patients (serving as controls). Arraystar Human LncRNA Array V4...
March 1, 2018: Life Sciences
Zhao-Fei Zhang, Dong-Hua Liu, Pei-Yu Wu, Chun-Liang Xie, Feng-Wei Qin, He Huang
OBJECTIVE: To evaluate the clinical effect of ultra-early injection (before the phase of "tooth-paste-like") of low-viscosity cement in percutaneous vertebroplasty (PVP) for treating osteoporotic vertebral compression fractures (OVCFs). METHODS: Two hundred sixty-one patients who had PVP procedures with low-viscosity cement (ultra-early injection: 145, normal injection: 135) were included from July 2010 to July 2016 in our hospital. Visual Analog Scale (VAS), Oswestry Disability Index (ODI), Cobb angle, cement leakage, and adjacent vertebral fractures were evaluated...
February 15, 2018: International Journal of Surgery
Feng Su, Wang He, Changhao Chen, Mo Liu, Hongwei Liu, Feiyuan Xue, Junming Bi, Dawei Xu, Yue Zhao, Jian Huang, Tianxin Lin, Chun Jiang
Long non-coding RNAs (lncRNAs) have been identified as significant regulators in cancer progression. Positive feedback loops between lncRNAs and transcription factors have attracted increasing attention. Akt pathway plays a crucial role in bladder cancer growth and recurrence. In the present study, we demonstrate a novel regulatory pattern involving FOXD2-AS1, Akt, and E2F1. FOXD2-AS1 is highly expressed in bladder cancer and is associated with tumor stage, recurrence, and poor prognosis. Further experiments showed that FOXD2-AS1 promotes bladder cancer cell proliferation, migration, and invasion in vitro and in vivo...
February 14, 2018: Cell Death & Disease
Zhen-Xiong Wang, Shen Qin, Li-Hua Xu, He-Ping Chen, Huan Sun, Rong Huang, Zheng-Hui Li, Tao Feng, Ji-Kai Liu
Three new lactones, xylanilyticolides A-C (1-3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60, A-549, SMMC-7721, MCF-7 and SW480 with the IC50values of 3.9, 15.2, 11.2, 5.9, and 4.7 μM, respectively.
February 13, 2018: Natural Products and Bioprospecting
Tie-Feng Song, Li-Wen Huang, Ying Yuan, Hui-Qin Wang, Hong-Peng He, Wen-Jian Ma, Li-Hong Huo, Hao Zhou, Nan Wang, Tong-Cun Zhang
Vascular smooth muscle cells (VSMCs), switching from a differentiated to a proliferative phenotype, contribute to various vascular diseases. However, the role of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 MALAT1 in the phenotype switching of VSMCs remains unclear. Here, we report that the knockdown of MALAT1 promotes the transformation of smooth muscle cells from a proliferative phenotype to a differentiated phenotype. MALAT1 knockdown inhibited cellular proliferation and migration, leading to significant cell cycle arrest in the G2 phase...
January 12, 2018: Oncotarget
Shenghua He, Hualong Feng, Zhiming Lan, Juyi Lai, Zhitao Sun, Yeguang Wang, Jian Wang, Zhiqiang Ren, Feiqiang Huang, Fuguang Xu
STUDY DESIGN: Prospective randomized study from a single center OBJECTIVE.: The purpose of this study was to compare outcomes between a zero-profile (ZP) anterior cervical discectomy and fusion (ACDF) construct to a traditional ACDF with anterior cervical plate (ACP) in the treatment of multilevel cervical spondylotic myelopathy. SUMMARY OF BACKGROUND DATA: Multilevel cervical spondylotic myelopathy can be treated by a variety of techniques, most commonly with corpectomy, ACDF, posterior cervical fusion, or a combination of the three...
March 1, 2018: Spine
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