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https://www.readbyqxmd.com/read/29150546/differential-regulation-of-two-tiered-plant-immunity-and-sexual-reproduction-by-anxur-receptor-like-kinases
#1
Hyunggon Mang, Baomin Feng, Zhangjian Hu, Aurelien Boisson-Dernier, Christina Franck, Xiangzong Meng, Yanyan Huang, Jinggeng Zhou, Guangyuan Xu, Taotao Wang, Libo Shan, Ping He
Plants have evolved two tiers of immune receptors to detect infections: cell surface-resident pattern recognition receptors (PRRs) that sense microbial signatures and intracellular nucleotide-binding domain leucine-rich repeat (NLR) proteins that recognize pathogen effectors. How PRRs and NLRs interconnect and activate the specific and overlapping plant immune responses remains elusive. A genetic screen for components controlling plant immunity identified ANXUR1 (ANX1), a malectin-like domain-containing receptor-like kinase, together with its homolog ANX2, as important negative regulators of both PRR- and NLR-mediated immunity in Arabidopsis thaliana...
November 17, 2017: Plant Cell
https://www.readbyqxmd.com/read/29132927/whole-exome-sequencing-identified-a-pathogenic-mutation-in-ryr2-in-a-chinese-family-with-unexplained-sudden-death
#2
Yubi Lin, Siqi He, Zili Liao, Ruiling Feng, Ruilin Liu, Yongzheng Peng, Nan Yu, Hang Qi, Jia Chen, Zifeng Huang, Heping Lei, Yang Liu, Fang Rao, Chunyu Deng, Yumei Xue, Guolin Zhang, Bin Zhang, Hua Yao, Shulin Wu
OBJECTIVE: This study aimed to identify the pathogenic mutation in a Chinese family with unexplained sudden death (USD) or occasional syncope. MATERIALS AND METHODS: Whole exome sequencing and target capture sequencing were respectively conducted for two related patients. The genetic data was screened using the 1000 genomes project and SNP database (PubMed), and the identified mutations were assessed for predicted pathogenicity using the SIFT and Polyphen-2 algorithms...
October 10, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29132870/mtor-inhibitor-rapamycin-induce-polymorphonuclear-myeloid-derived-suppressor-cells-mobilization-and-function-in-protecting-against-acute-graft-versus-host-disease-after-bone-marrow-transplantation
#3
Yu Lin, Binsheng Wang, Wei Shan, Yamin Tan, Jingjing Feng, Lin Xu, Limengmeng Wang, Biqing Han, Mingming Zhang, Jian Yu, Xiaohong Yu, He Huang
The mammalian target of rapamycin (mTOR) inhibitor rapamycin (RAPA) has been shown to be an effective immunosuppressor in the management of acute graft-versus-host disease (aGVHD) after bone marrow transplantation. Myeloid-derived suppressor cells (MDSCs) also have a protective effect in aGVHD regulation. However, the relationship between RAPA and MDSCs in aGVHD models is unclear. Meanwhile, the effect of RAPA on different subgroups of MDSCs is also less well described. In this study, we demonstrate that in vivo administration of RAPA results in the expansion and functional enhancement of polymorphonuclear MDSCs (PMN-MDSCs) in a murine model of aGVHD...
November 10, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29129906/correlation-of-maternal-serum-homocysteine-in-the-first-trimester-with-the-development-of-gestational-hypertension-and-preeclampsia
#4
Feng Sun, Wei Qian, Chen Zhang, Jian-Xia Fan, He-Feng Huang
BACKGROUND This study investigated the relationship of serum homocysteine in early pregnancy with the risk of gestational hypertension (GH) and preeclampsia (PE) and with the severity of preeclampsia. MATERIAL AND METHODS In a retrospective cohort study, we identified 147 confirmed cases of preeclampsia (103 with mild PE and 44 with severe PE) and 147 confirmed cases of GH; 4418 women who remained normotensive and nonproteinuric throughout pregnancy served as controls. Maternal blood samples were collected at between 11 and 13 weeks of gestation to test serum concentrations of homocysteine (Hcy), folic acid, and VitB12...
November 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29129657/transport-mechanism-of-lipid-covered-saquinavir-pure-drug-nanoparticles-in-intestinal-epithelium
#5
Dengning Xia, Yuan He, Qiuxia Li, Cunde Hu, Wei Huang, Yunhai Zhang, Feng Wan, Chi Wang, Yong Gan
Pure drug nanoparticles (NPs) represent a promising formulation for improved drug solubility and controlled dissolution velocity. However, limited absorption by the intestinal epithelium remains challenge to their clinical application, and little is known about how these NPs within the cells are transported. To improve cellular uptake and transport of pure nanodrug in cells, here, a lipid covered saquinavir (SQV) pure drug NP (Lipo@nanodrug) was designed by modifying a pure SQV NP (nanodrug) with a phospholipid bilayer...
November 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29129340/synchronous-colorectal-cancer-and-multiple-myeloma-with-chest-wall-involvement-is-this-a-coincidence
#6
Qiu-Li Li, Jin-An Ma, Hai-Peng Li, Ren-Bing Huang, Chun-Hong Hu, Xian-Ling Liu, Ya-Wen Gao, Gang-Hua Feng, Fang Wu
Multiple primary malignant neoplasms (MPMNs) are rare malignant neoplasms that simultaneously or successively occur in the same patient as 2 or more primary malignancies. Currently, an increasing number of cases are being reported. In general, MPMNs more commonly occur as 2 solid tumors or 2 hematological malignancies. Cases of MPMN that involve a solid tumor and a hematological malignancy are rare. Here, we report a case of synchronous colorectal cancer (CRC) and multiple myeloma (MM) with chest wall involvement...
September 25, 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/29127408/statistical-analysis-for-collision-free-boson-sampling
#7
He-Liang Huang, Han-Sen Zhong, Tan Li, Feng-Guang Li, Xiang-Qun Fu, Shuo Zhang, Xiang Wang, Wan-Su Bao
Boson sampling is strongly believed to be intractable for classical computers but solvable with photons in linear optics, which raises widespread concern as a rapid way to demonstrate the quantum supremacy. However, due to its solution is mathematically unverifiable, how to certify the experimental results becomes a major difficulty in the boson sampling experiment. Here, we develop a statistical analysis scheme to experimentally certify the collision-free boson sampling. Numerical simulations are performed to show the feasibility and practicability of our scheme, and the effects of realistic experimental conditions are also considered, demonstrating that our proposed scheme is experimentally friendly...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116688/facile-synthesis-of-highly-water-soluble-lanthanide-doped-t-lavo4-nps-for-antifake-ink-and-latent-fingermark-detection
#8
Cailing Chen, Ying Yu, Chunguang Li, Dan Liu, He Huang, Chen Liang, Yue Lou, Yu Han, Zhan Shi, Shouhua Feng
In the information age, it is important to protect the security and integrity of the information. As a result, the fluorescent ink as an antifake technology and the fingermark as an information carrier have aroused great interest. In this work, highly water-soluble lanthanide (Ln(3+) )-doped tetragonal phase (t-) LaVO4 nanoparticles (NPs) are successfully obtained via a simple, fast, and green microwave-assisted hydrothermal method. The average size of t-LaVO4 NPs is about 43 nm. The aqueous solutions of Ln(3+) -doped t-LaVO4 exhibit excellent fluorescence properties under ultraviolet light (UV) excitation (t-LaVO4 :10%Eu is bright red and t-LaVO4 :0...
November 8, 2017: Small
https://www.readbyqxmd.com/read/29115406/berberine-prevents-the-apoptosis-of-mouse-podocytes-induced-by-traf5-overexpression-by-suppressing-nf-%C3%AE%C2%BAb-activation
#9
Feng Wu, Dong-Sheng Yao, Tian-Ying Lan, Chen Wang, Jian-Dong Gao, Li-Qun He, Di Huang
Berberine (BBR) has previously been found to exert beneficial effects on renal injury in experimental rats. However, the mechanisms underlying these effects are not yet fully understood. Tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) has been demonstrated to mediate the activation of nuclear factor-κB (NF-κB), which has been implicated in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to investigate the effects of BBR on kidney injury and the activation of the NF-κB signaling pathway in mouse podocytes...
November 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29114931/thrombotic-microangiopathy-with-concomitant-gi-agvhd-after-allogeneic-hematopoietic-stem-cell-transplantation-risk-factors-and-outcome
#10
Xiao-Hui Zhang, Xiao Liu, Qin-Ming Wang, Yun He, Xiao-Lu Zhu, Jia-Min Zhang, Wei Han, Huan Chen, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yuan-Yuan Zhang, Xiao-Dong Mo, Yao Chen, Yu Wang, Hai-Xia Fu, Ying-Jun Chang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang
OBJECTIVES: To explore the possible risk factors for the occurrence and mortality of TMA with concomitant aGVHD and to investigate outcomes and treatments of this disorder after allo-HSCT. METHODS: 50 cases diagnosed with TMA with concomitant aGVHD and 150 controls were identified from a cohort composed of 3 992 patients who underwent allo-HSCT from 2008 to 2016. RESULTS: Grade III-IV aGVHD (p=0.000), acute kidney injury (AKI) (p=0.033) and hypertension (p=0...
November 7, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29101185/advanced-oxidation-protein-products-aggravate-cardiac-remodeling-via-cardiomyocyte-apoptosis-in-chronic-kidney-disease
#11
Weijing Feng, Kun Zhang, Yu Liu, Jie Chen, Qingqing Cai, Wanbing He He, Yinyin Zhang, Mong-Heng Wang, Jingfeng Wang, Hui Huang
Advanced oxidation protein products (AOPPs) are independent risk factor for various cardiovascular diseases. Cardiomyocyte apoptosis has been implicated as an important mechanism in cardiac remodeling in chronic kidney disease (CKD). However, whether AOPPs affect cardiomyocyte apoptosis and subsequent cardiac remodeling in CKD is still not very clear. Here, we assessed the role of AOPPs in cardiomyocyte apoptosis in CKD. H9C2 rat cardiomyoblast cells were exposed to AOPPs. The apoptotic cells were determined by TUNEL assay...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29098483/irisin-alleviates-advanced-glycation-end-products-induced-inflammation-and-endothelial-dysfunction-via-inhibiting-ros-nlrp3-inflammasome-signaling
#12
Xian Deng, Wei Huang, Juan Peng, Ting-Ting Zhu, Xiao-Lei Sun, Xiang-Yu Zhou, Hui Yang, Jian-Feng Xiong, Hu-Qiang He, You-Hua Xu, Yan-Zheng He
The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome have been implicated in the initiation or progression of atherosclerosis. Recent research showed that irisin, a newly discovered adipomiokine, alleviates endothelial dysfunction in type 2 diabetes partially via reducing oxidative/nitrative stresses, suggesting that irisin may be a promising candidate for the treatment of vascular complications of diabetes. However, the association between irisin and NLRP3 inflammasome in the pathogenesis of atherosclerosis remains unclear...
November 2, 2017: Inflammation
https://www.readbyqxmd.com/read/29093513/high-fat-diet-and-chronic-stress-aggravate-adrenal-function-abnormality-induced-by-prenatal-caffeine-exposure-in-male-offspring-rats
#13
Zheng He, Feng Lv, Yufeng Ding, Hegui Huang, Lian Liu, Chunyan Zhu, Youyin Lei, Li Zhang, Cai Si, Hui Wang
We previously demonstrated thatprenatal caffeine exposure (PCE) suppressed fetal adrenal steroidogenesis and resulted in developmental programming changes in offspring rats. However, whether these changes play a role in adrenal corticosterone synthesis under high-fat diet (HFD) and unpredictable chronic stress (UCS) remains unknown. In present study, rat model was established by PCE (120 mg/kg.d), and male offspring were provided normal diet or HFD after weaning. At postnatal week 21, several rats fed HFD were exposed to UCS for 3 weeks and sacrificed...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29089968/targeting-of-auf1-to-vascular-endothelial-cells-as-a-novel-anti-aging-therapy
#14
Jian He, Ya-Feng Jiang, Liu Liang, Du-Jin Wang, Wen-Xin Wei, Pan-Pan Ji, Yao-Chan Huang, Hui Song, Xiao-Ling Lu, Yong-Xiang Zhao
BACKGROUND: Inhibition of aging of vascular endothelial cells (VECs) may delay aging and prolong life. The goal of this study was to prepare anti-CD31 monoclonal antibody conjugated PEG-modified liposomes containing the AU-rich region connecting factor 1 (AUF1) gene (CD31-PILs-AUF1) and to explore the effects of targeting CD31-PILs-AUF1 to aging VECs. METHODS: The mean particle sizes of various PEGylated immunoliposomes (PILs) were measured using a Zetasizer Nano ZS...
August 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29082701/-effect-of-mirna-from-glycyrrhiza-uralensis-decoction-on-gene-expression-of-human-immune-cells
#15
Jing Xiang, Jie-Chang Huang, Chang Xu, Mian He, Peng-Cheng Xu, Dan Zhang, Wen-Feng Zhang, Han Shen, Hong-Wei Shao
MicroRNAs(miRNA) are small non-coding RNAs that regulate the expression of protein coding genes by repressing translation of protein coding mRNA or enhancing mRNA degradation. Its functions have attracted more and more attention from the public. In recent years, the cross-border regulation of miRNA has become a new research direction, and provides a new perspective for people to comprehensively understand the functions of miRNA. Plant miRNA is usually methylated and not easy to degrade. According to our previous researches, there were abundant small RNAs in the decoction of dried liquorice, which provides a new way to study the mechanism of action of licorice...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29080622/elevated-serum-prostaglandin-e2-predicts-the-risk-of-infection-in-hepatitis-b-virus-related-acute-on-chronic-liver-failure-patients
#16
Xiao-Ping Huang, Yan Wang, Li Chen, Wei Sun, Yan Huang, Ying Xu, Ting-Ting Feng, Er-Ping Luo, Ai-Lan Qin, Wei-Feng Zhao, Jian-He Gan
OBJECTIVE: To evaluate the serum Prostaglandin E2 (PGE2) level in Acute-on-chronic liver failure (ACLF) and determine its predicative value for infection. METHODS: From April 2014 to April 2015, ninety-one patients with hepatitis B virus and ACLF but without infection were enrolled into this prospective study that was carried out at our Hospital. Twenty patients with stable chronic hepatitis B were enrolled from the outpatient department and twenty healthy control subjects without any disease were enrolled from hospital staff...
September 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29078125/posterior-c1-c2-screw-rod-fixation-and-autograft-fusion-for-the-treatment-of-os-odontoideum-with-c1-c2-instability
#17
Da-Geng Huang, Tao Wang, Ding-Jun Hao, Bao-Rong He, Tuan-Jiang Liu, Xiao-Wen Ma, Cheng-Cheng Yu, Hang Feng, Song-Chuan Zhao, Hua Hui
OBJECTIVE: To report our experience treating os odontoideum with C1-C2 instability via C1-C2 screw-rod fixation and autograft fusion and to explore the clinical efficacy of such a treatment strategy. PATIENTS AND METHODS: We retrospectively reviewed the medical records of patients who were diagnosed with os odontoideum with C1-C2 instability and treated by posterior C1-C2 screw-rod fixation and fusion. Neurological deficits were measured with the Japanese Orthopedic Association (JOA) scoring system and neck pain was assessed using the Visual Analogue Scale (VAS) score...
October 19, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29061377/a-cyclo-trimer-of-acetonitrile-combining-fluorescent-property-with-ability-to-induce-osteogenesis-and-its-potential-as-multifunctional-biomaterial
#18
Xujie Liu, Yong Xie, Rui Liu, Ranran Zhang, Hao Yan, Xing Yang, Qianli Huang, Wei He, Bo Yu, Qingling Feng, Shengli Mi, Qiang Cai
A biomaterial combining fluorescent property with ability to induce osteogenesis can serve as an ideal multifunctional scaffold in bone tissue engineering. However, the frequently used fluorescent agents can only serve as imaging probes. The polymer or oligomer with a conjugated system containing nitrogen atoms will fulfill these criteria. In this study, a cyclo-trimer of acetonitrile is synthesized using a facile method, which is proved to be 4-amino-2,6-dimethylpyrimidine. The cyclo-trimer of acetonitrile demonstrates strong intrinsic photoluminescence and has the potential for in vivo imaging...
October 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29053998/effects-of-ball-milling-on-the-physicochemical-and-sorptive-properties-of-biochar-experimental-observations-and-governing-mechanisms
#19
Honghong Lyu, Bin Gao, Feng He, Andrew R Zimmerman, Cheng Ding, Hua Huang, Jingchun Tang
With the goal of combining the advantages of ball-milling and biochar technologies, a variety of ball-milled biochars (BM-biochars) were synthesized, characterized, and tested for nickel (Ni(II)) removal from aqueous solution. Ball milling increased only the external surface area of low temperature biochars, but still dramatically enhanced their ability to sorb aqueous Ni(II). For higher temperature biochars with relatively low surface area, ball milling increased both external and internal surface area. Measurements of pH, zeta potential, stability, and Boehm titration demonstrated that ball milling also added oxygen-containing functional groups (e...
October 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29046127/serum-ferritin-is-a-different-predictor-from-transfusion-history-for-allogeneic-transplantation-outcome-in-patients-with-severe-aplastic-anemia
#20
Xiaoyu Zhang, Yuanyuan Shi, Yong Huang, Guixin Zhang, Yi He, Erlie Jiang, Jialin Wei, Donglin Yang, Qiaoling Ma, Rongli Zhang, Weihua Zhai, Sizhou Feng, Mingzhe Han
OBJECTIVES: Severe aplastic anemia (SAA) patients receive more red blood cell (RBC) transfusions as supportive management. We aim to clarify the associations between transfusion history or pre-transplantation serum ferritin (SF) and the overall survival of allogeneic hematopoietic stem cell transplantation (allo-HSCT) among SAA patients. MATERIAL AND METHODS: We retrospectively investigated 96 SAA patients undergoing allo-HSCT, and grouped them according to pre-transplantation duration...
October 18, 2017: Hematology (Amsterdam, Netherlands)
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