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https://www.readbyqxmd.com/read/28923636/effect-of-preoperative-growth-status-on-clinical-outcomes-after-living-donor-liver-transplantation-in-infants
#1
Y Lu, Q Xia, Y Yang, P Wan, J Hou, Y Wang, B Qiu, M Feng, K He, M Huang, X Ren, L Gao, J Zhang
OBJECTIVE: The aim of this study was to evaluate the impact of preoperative growth status on clinical outcomes of infantile living-donor liver transplantation (LDLT). METHODS: From January 2009 to December 2014, 131 LDLT recipients ≤1 year of age met the eligibility criteria of this study, of whom 31 patients with weight z-scores less than -2 constituted the abnormal growth group. Patients in the abnormal growth group were randomly matched (1:1) to patients with normal growth status by means of a multivariate case-matched method, and thus 31 patients in the normal growth group and 31 patients in the abnormal growth group were finally enrolled into the study...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28915649/digoxin-induced-anemia-among-patients-with-atrial-fibrillation-and-heart-failure-clinical-data-analysis-and-drug-gene-interaction-network
#2
Yubi Lin, Siqi He, Ruiling Feng, Zhe Xu, Wanqun Chen, Zifeng Huang, Yang Liu, Qianhuan Zhang, Bin Zhang, Kejian Wang, Shulin Wu
Digoxin is widely used to treat various heart conditions. In order to clarify the association between digoxin and anemia adverse reaction, we inspected case reports submitted to the FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015. These reports involved 75618 atrial fibrillation patients and 15699 heart failure patients. Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912857/overexpression-of-transcription-factor-activating-enhancer-binding-protein-4-tfap4-predicts-poor-prognosis-for-colorectal-cancer-patients
#3
Jianchang Wei, Ping Yang, Tong Zhang, Zhuanpeng Chen, Wei Chen, Li Wanglin, Feng He, Fang Wei, Di Huang, Junbin Zhong, Zhi Yang, Huacui Chen, He Hu, Shanqi Zeng, Zheng Sun, Jie Cao
Transcription factor activating enhancer binding protein 4 (TFAP4) is an important regulator in the genesis and progression of human cancers. Overexpression of TFAP4 has been found to be correlated with several malignancies. The present study assessed the clinical importance of TFAP4 in colorectal cancer (CRC). First, immunohistochemistry was used to analyze TFAP4 expression and the association of TFAP4 expression with clinicopathological features on a tissue microarray containing 208 CRC patients. The results revealed that TFAP4 protein expression was significantly upregulated in CRC tissues compared with that in normal colon tissues (P<0...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912043/abnormal-segments-of-right-uncinate-fasciculus-and-left-anterior-thalamic-radiation-in-major-and-bipolar-depression
#4
Feng Deng, Ying Wang, Huiyuan Huang, Meiqi Niu, Shuming Zhong, Ling Zhao, Zhangzhang Qi, Xiaoyan Wu, Yao Sun, Chen Niu, Yuan He, Li Huang, Ruiwang Huang
Differential brain structural abnormalities between bipolar disorder (BD) and major depressive disorder (MDD) may reflect different pathological mechanisms underlying these two brain disorders. However, few studies have directly compared the brain structural properties, especially in white matter (WM) tracts, between BD and MDD. Using automated fiber-tract quantification (AFQ), we utilized diffusion tensor images (DTI) from 67 unmedicated depressed patients, including 31 BD and 36 MDD, and 45 healthy controls (HC) to create fractional anisotropy (FA) tract profiles along 20 major WM tracts...
September 11, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28906036/phosphorus-and-fluorine-co-doping-induced-enhancement-of-oxygen-evolution-reaction-in-bimetallic-nitride-nanorods-arrays-ionic-liquid-driven-and-mechanism-clarification
#5
Xue Bai, Qin Wang, Feng He, Zhi-Jian Wu, Guangran Xu, Keke Huang, Yunkun Ning, Jun Zhang
Electrocatalytic splitting of water is becoming increasingly crucial for renewable energy and device technologies. As one of the most important half-reactions for water splitting reaction, oxygen evolution reaction (OER) is a kinetically sluggish process that will greatly affect the energy conversion efficiency. Therefore, exploring a highly efficient, and durable catalyst to boost the OER is of great urgency. In this work, we develop a facile strategy for synthesis of well-defined phosphorus, fluorine co-doped Ni1...
September 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28890726/next-generation-sequencing-aided-rapid-molecular-diagnosis-of-occult-macular-dystrophy-in-a-chinese-family
#6
Yu-He Qi, Feng-Juan Gao, Fang-Yuan Hu, Sheng-Hai Zhang, Jun-Yi Chen, Wan-Jing Huang, Guo-Hong Tian, Min Wang, De-Kang Gan, Ji-Hong Wu, Ge-Zhi Xu
Purpose: To show early, rapid and accurate molecular diagnosis of occult macular dystrophy (OMD) in a four-generation Chinese family with inherited macular dystrophy. Methods: In the current study, we comprehensively screened 130 genes involved in common inherited non-syndromic eye diseases with next-generation sequencing-based target capture sequencing of the proband of a four-generation Chinese family that has suffered from maculopathy without a definitive diagnosis for over 10 years. Variants were filtered and analyzed to identify possible disease-causing variants before validation by Sanger sequencing...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28887982/the-negative-effect-of-silica-nanoparticles-on-adipogenic-differentiation-of-human-mesenchymal-stem-cells
#7
Xing Yang, Xujie Liu, Yuanyuan Li, Qianli Huang, Wei He, Ranran Zhang, Qingling Feng, Dafna Benayahu
Nanoparticles have drawn much attention for a wide variety of applications in biomedical and bioengineering fields. The combined use of nanoparticles and human mesenchymal stem cells (hMSCs) in tissue engineering and regenerative medicine requires more knowledge of the influence of nanoparticles on cell viability and differentiation potential of hMSCs. The objective of this study is to investigate the in vitro uptake of silica nanoparticles (silica NPs) and their effect on adipogenic differentiation of hMSCs...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28886461/time-dependent-effects-of-olanzapine-treatment-on-the-expression-of-histidine-decarboxylase-h1-and-h3-receptor-in-the-rat-brain-the-roles-in-olanzapine-induced-obesity
#8
Meng He, Qingsheng Zhang, Chao Deng, Tiantian Jin, Xueqin Song, Hongqing Wang, Xu-Feng Huang
Antipsychotic treatment, particularly olanzapine and clozapine, induces severe obesity. The Histamine H1 receptor is considered to be an important contributor to olanzapine-induced obesity, however how olanzapine modulates the histaminergic system is not sufficiently understood. This study examined the effect of olanzapine on key molecules of the histaminergic system, including histidine decarboxylase (HDC), H1 receptor (H1R) and H3 receptor (H3R), in the brain at different stages of olanzapine-induced obesity...
August 24, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28881823/hypertriglyceridemia-in-female-rats-during-pregnancy-induces-obesity-in-male-offspring-via-altering-hypothalamic-leptin-signaling
#9
Tanzil Ur Rahman, Kamran Ullah, Zhang-Hong Ke, Meng-Xi Guo, Lu-Yang Jin, Jun Ren, Yu-Zhong Zhou, Yi Cheng, Xin-Yan Dong, Hai-Yan Pang, Ting-Ting Wang, Jian-Zhong Sheng, He-Feng Huang
Maternal obesity influence the child's long-term development and health. Though, the mechanism concerned in this process is still uncertain. In the present study, we explored whether overfeeding of a high-fat diet during pregnancy in female rats altered metabolic phenotypes in an F1 generation and authenticated the contribution of hypothalamic leptin signaling. Leptin responsiveness and the number of immunopositive neurons for phosphorylated signal transducer and activator transcription 3 (pSTAT3) were analyzed...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878204/analysis-of-antineutrophil-cytoplasm-antibody-from-118-730-patients-in-tertiary-hospitals-in-jiangxi-province-china
#10
Liming Tan, Anjun Jiao, Juanjuan Chen, Xiaojing Feng, Liuyue Xu, Siqi He, Fuyan Tan, Yongqing Jiang, Heng Luo, Hua Li, Yang Wu, Yongjian Tian, Tingting Zeng, Jianlin Yu, Liping Cao, Jianfeng Zheng, Hui Xu, Ming Wei, Wen Gan, Weihua Peng, Yanming Liu, Jing Hou, Jiangxia Xu, LiHua Shuai, Wenzhi Huang, Junyun Huang, Yan Lin, Jianrong Liu
BACKGROUND The discovery of antineutrophil cytoplasm antibody (ANCA) makes the early diagnosis of primary vasculitis possible, and also has important guiding significance for the diagnosis and treatment of secondary vasculitis. This study aimed to investigate the clinical significance of ANCA. MATERIAL AND METHODS ANCA was detected by indirect immunofluorescence assay (IIF), and anti-myeloperoxidase (MPO) antibody, and anti-proteinase 3 (PR3) antibody were detected by ELISA. The results were analyzed retrospectively...
September 7, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28877835/pathological-changes-in-app-ps-1-transgenic-mouse-models-of-alzheimer-s-disease-treated-with-ganoderma-lucidum-preparation
#11
Chuan Qin, Shan-Qiu Wu, Bao-Sheng Chen, Xiao-Xian Wu, Kun-Yao Qu, Jun-Min Liu, Gui-Fang Zhang, Yan-Feng Xu, Shunli Shu, Lihua Sun, Yan-Yong Li, Hua Zhu, Lan Huang, Chun-Mei Ma, Yu-Huan Xu, Yun-Lin Han, Yao-Zeng Lu
Objective To explore the efficacy of ganoderma lucidum preparation(Ling Zhi) in treating APP/PS-1 transgenic mouse models of Alzheimer's disease(AD).Methods APP/PS-1 transgenic mice of 4 months were randomly divided into model group,ganoderma lucidum treatment groups,including high [2250 mg/(kg·d)] and middle [750 mg/(kg·d)] dose groups,i.e.LZ-H and LZ-M groups,and the positive control group(treated with donepezil hydrochloride [2 mg/(kg·d)]).In addition,C57BL/6J wild mice were selected as normal group.The animals were administered for 4 months...
August 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28874712/pglyco-2-0-enables-precision-n-glycoproteomics-with-comprehensive-quality-control-and-one-step-mass-spectrometry-for-intact-glycopeptide-identification
#12
Ming-Qi Liu, Wen-Feng Zeng, Pan Fang, Wei-Qian Cao, Chao Liu, Guo-Quan Yan, Yang Zhang, Chao Peng, Jian-Qiang Wu, Xiao-Jin Zhang, Hui-Jun Tu, Hao Chi, Rui-Xiang Sun, Yong Cao, Meng-Qiu Dong, Bi-Yun Jiang, Jiang-Ming Huang, Hua-Li Shen, Catherine C L Wong, Si-Min He, Peng-Yuan Yang
The precise and large-scale identification of intact glycopeptides is a critical step in glycoproteomics. Owing to the complexity of glycosylation, the current overall throughput, data quality and accessibility of intact glycopeptide identification lack behind those in routine proteomic analyses. Here, we propose a workflow for the precise high-throughput identification of intact N-glycopeptides at the proteome scale using stepped-energy fragmentation and a dedicated search engine. pGlyco 2.0 conducts comprehensive quality control including false discovery rate evaluation at all three levels of matches to glycans, peptides and glycopeptides, improving the current level of accuracy of intact glycopeptide identification...
September 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28860713/metformin-a-review-of-its-potential-indications
#13
REVIEW
Yi-Wei Wang, Si-Jia He, Xiao Feng, Jin Cheng, Yun-Tao Luo, Ling Tian, Qian Huang
Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. In recent years, in addition to glucose lowering, several studies have presented evidence suggesting some potential role for metformin, such as antitumor effect, antiaging effect, cardiovascular protective effect, neuroprotective effect or an optional treatment for polycystic ovary syndrome. This paper will critically review the role of metformin to provide reference for doctors and researchers.
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28857561/identification-of-missing-proteins-in-the-phosphoproteome-of-kidney-cancer
#14
Xuehui Peng, Feng Xu, Shu Liu, Suzhen Li, Qingbo Huang, Lei Chang, Lei Wang, Xin Ma, Fuchu He, Ping Xu
Identifying missing proteins (MPs) has been one of the critical missions of the Chromosome-Centric Human Proteome Project (C-HPP). Since 2012, over 30 research teams from 17 countries have been trying to search adequate and accurate evidence of MPs through various biochemical strategies. MPs mainly fall into the following classes: (1) low-molecular-weight (LMW) proteins, (2) membrane proteins, (3) proteins that contained various post-translational modifications (PTMs), (4) nucleic acid-associated proteins, (5) low abundance, and (6) unexpressed genes...
September 12, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28836435/controlling-molecular-weight-of-hyaluronic-acid-conjugated-on-amine-rich-surface-toward-better-multifunctional-biomaterials-for-cardiovascular-implants
#15
Jingan Li, Feng Wu, Kun Zhang, Zikun He, Dan Zou, Xiao Luo, Yonghong Fan, Ping Yang, Ansha Zhao, Nan Huang
The molecular weights (MWs) of hyaluronic acid (HA) in extracellular matrix secreted from both vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs) play crucial roles in the cardiovascular physiology, as HA with appropriate MW influences important pathways of cardiovascular homeostasis, inhibits VSMC synthetic phenotype change and proliferation, inhibits platelet activation and aggregation, promotes endothelial monolayer repair and functionalization, and prevents inflammation and atherosclerosis...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28829837/transforming-growth-factor-%C3%AE-1-signaling-promotes-epithelial-mesenchymal-transition-like-phenomena-cell-motility-and-cell-invasion-in-synovial-sarcoma-cells
#16
Yan Qi, Ning Wang, Yonglai He, Jun Zhang, Hong Zou, Wenjie Zhang, Wenyi Gu, Yalan Huang, Xiaojuan Lian, Jianming Hu, Jin Zhao, Xiaobin Cui, Lijuan Pang, Feng Li
The epithelial-to-mesenchymal transition (EMT) and the reverse process (the mesenchymal-to-epithelial transition [MET]) have been shown to be associated with tumor cell invasion and metastasis in different carcinomas. The EMT and MET have recently been shown to play a key role in the pathogenic processes of sarcomas, which are completely different from those of carcinomas. However, the definitive roles of the EMT in the tumorigenesis of synovial sarcomas remain unknown. Here, we explored whether transforming growth factor (TGF)-β signaling, an important oncogenic event in synovial sarcoma, modulates tumor cell characteristics related to the EMT, such as cell adhesion, migration, invasion, and proliferation...
2017: PloS One
https://www.readbyqxmd.com/read/28803680/corrigendum-to-analysis-of-association-between-common-snps-in-erbb4-and-bipolar-affective-disorder-major-depressive-disorder-and-schizophrenia-in-the-han-chinese-population-prog-neuro-psychopharmacol-biol-psychiatry-36-2012-17-21
#17
P Chen, J Chen, K Huang, W Ji, T Wang, T Li, Y Wang, H Wang, L He, G Feng, Y Shi
No abstract text is available yet for this article.
August 10, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28801279/-high-frequency-echocardiography-for-assessment-of-regional-wall-motion-abnormality-and-cardiac-function-in-mice-with-myocardial-infarction
#18
Jing Wang, Wei-Jiang Tan, Xiang Li, Gui-Ping Zhang, Jia-Yuan Huang, Xiao-Hong Chen, Qian Lei, Feng-Hua Yang, Ren Huang
OBJECTIVE: To evaluate the value of high-frequency echocardiography in assessing cardiac structure and function in a mouse model of myocardial infarction. METHODS: Twenty-five C57BL/6 mice were randomly divided into sham-operated group (n=10) and myocardial infarction model group (n=15) established by ligation of the left anterior descending artery. The cardiac structure, regional wall motion and cardiac function of mice were examined with pulsed wave Doppler (PWD), tissue Doppler imaging (TDI), EKV and M-mode echocardiography 3 days before and at 1 week after the operation...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28790925/nlrp3-inflammasome-as-a-molecular-marker-in-diabetic-cardiomyopathy
#19
REVIEW
Beibei Luo, Feng Huang, Yanli Liu, Yiying Liang, Zhe Wei, Honghong Ke, Zhiyu Zeng, Weiqiang Huang, Yan He
Diabetic cardiomyopathy (DCM), a common consequence of longstanding diabetes mellitus, is initiated by death of cardiomyocyte. Hyperglycemia-induced reactive oxygen species (ROS) overproduction is a major contributor of the chronic low-grade inflammation that characterizes as the DCM. ROS may promote the activation of nucleotide-binding oligomerization domain like receptor (NLR) pyrin domain containing 3 (NLRP3) inflammasome, a novel regulator of inflammation and cell death, by nuclear factor-kB (NF-κB) and thioredoxin interacting/inhibiting protein (TXNIP)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28780796/-changes-of-integrin-linked-kinase-expression-on-rats-pulmonary-fibrosis-induced-by-paraquat
#20
Y W Su, Y H Li, F Li, Y C Feng, H Huang, B X Wei, Y M Liu
Objective: To observe the expression of integrin-linked kinase on pulmonary fibrosis of paraquat (PQ) poisoning rats, and to discuss the relationship between ILK with pulmonary fibrosis induced by paraquat. Methods: Forty male Sprague-Dawley (SD) rats were randomly divided into control group and paraquat group, 20 in each group; the PQ group rats were intraperitoneally injected PQ liquid (18 mg/kg) , and the control group rats were injected the same volume of saline; 5 rats of these two groups were respectively sacrificed after 7, 14, 28, 56 days of PQ injection; according to the results of lung biopsy HE staining and Masson staining to observe the lung pathologic changes, measure the value of lung hydroxyproline and the expression of ILK...
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
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