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Ischemic mitral

Patrizia Aruta, Denisa Muraru, Andrada Camelia Guta, Sorina Mihaila, Niccolò Ruozi, Chiara Palermo, Basma Elnagar, Sabino Iliceto, Luigi P Badano
BACKGROUND: Transcatheter mitral valve replacement (TMVR) is a new therapeutic option for high surgical risk patients with mitral regurgitation (MR). Mitral valve (MV) geometry quantification is of paramount importance for success of the procedure and transthoracic 3D echocardiography represents a useful screening tool. Accordingly, we sought to asses MV geometry in patients with functional MR (FMR) that would potentially benefit of TMVR, focusing on the comparison of mitral annulus (MA) geometry between patients with ischemic (IMR) and non ischemic mitral regurgitation (nIMR)...
October 12, 2018: Cardiovascular Ultrasound
Mehmet Adnan Celkan, Ismail Kork, Abdullah Ulucay
BACKGROUND: In this study, we present the outcomes of 53 patients with concomitant coronary artery disease and ischemic mitral regurgitation (IMR)who underwent coronary bypass grafting (CABG) plus mitral repair (flexible posterior band annuloplasty). MATERIALS AND METHODS: A total of 53 patients with concomitant ischemic mitral regurgitation  and coronary artery disease underwent CABG plus posterior mitral band annuloplasty between June 2008 and June 2015. Flexible Duran AnCore® annuloplasty band (Medtronic) was used in all patients...
August 14, 2018: Heart Surgery Forum
Sina Stock, Michael Scharfschwerdt, Rebecca Janina Warnecke, Doreen Richardt, Stanislav Tsvelodub, Hans-Hinrich Sievers
BACKGROUND:  Optimal surgical treatment of functional ischemic mitral regurgitation (FIMR) is still controversy. Due to the underlying pathophysiology, stand-alone ring annuloplasty is assumed with a high recurrence rate of mitral regurgitation, thus additional subvalvular repair techniques might improve the results. This in vitro study introduces a new device for subvalvular mitral valve repair. METHODS:  We developed a new device for subvalvular mitral valve repair, consisting of two frames for papillary muscle (PM) attachment, which are connected with two holding bars serving for fixation of the device on an annuloplasty ring...
October 8, 2018: Thoracic and Cardiovascular Surgeon
Calcagno Simone, Cimino Sara, Cerbelli Bruna, Sardella Gennaro
Cerebral ischemic lesions occurring during transcatheter valve interventions are common feared complications and the use of filter device seems to reduce their incidence. We report the case of an 84-year old female patient with severe mitral regurgitation undergoing MitraClip. During the trans-esophageal echocardiography (TEE)-guided procedure was detected the presence of a little fibrin strand adherent to the steerable guide catheter for which we decided to implant the Claret CE Pro (Claret Medical, Inc. Santa Rosa, CA, USA) cerebral protection device and to continue the procedure during which the thrombus disappeared...
October 4, 2018: Catheterization and Cardiovascular Interventions
Laura Leticia Rodríguez-Chávez, Grecia Iveth Maryelis Raymundo-Martínez, Rodrigo Gopar-Nieto
There is no report of four valve replacement surgeries in a woman during 15-year follow-up. A 23-year-old female was diagnosed at 7 years with rheumatic fever. She developed severe mitral regurgitation and at the same age a prosthetic valve was placed. In the next 15 years her mitral valve was changed 3 times because of clinical, echocardiographic, and histopathologic evidence of thrombosis. Her coagulation tests all showed infratherapeutic international normalized ratio and by the age of 15 years she had had an ischemic stroke with total recovery...
September 2018: Journal of Cardiology Cases
Victor A Abrich, Aalap D Narichania, William T Love, Louis A Lanza, Win-Kuang Shen, Dan Sorajja
PURPOSE: The purpose of this study was to determine whether surgical left atrial appendage (LAA) exclusion performed during mitral valve surgery is associated with a reduction in cerebrovascular events in patients with atrial fibrillation. METHODS: We retrospectively studied patients with atrial fibrillation who underwent mitral valve surgery from 1/1/2001 through 12/31/2014. We screened 1352 patients using ICD-9 codes and included 281 patients in the study. The primary end point was a composite of strokes and transient ischemic attacks occurring within 5 years after surgery...
September 28, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Guglielmo Stefanelli, Fabrizio Pirro, Alina Olaru, Paolo Giovanardi, Marco Meli, Mauro Concari, Paolo L Weltert
INTRODUCTION: Aim of this study is to verify the potential advantages and benefits of bone-marrow derived autologous stem cells implantation associated to surgical left ventricular restoration(SVR),to report a new modality of cell delivery to myocardium ,and to identify possible side effects of this procedure. METHODS: Between March,2007 and March,2013,30 patients affected by ischemic dilative cardiomyopathy who received a SVR operation were enrolled in the study...
September 26, 2018: Minerva Cardioangiologica
John Bozinovski
No abstract text is available yet for this article.
October 2018: Journal of Thoracic and Cardiovascular Surgery
Martina Nassif, Reindert P van Steenwijk, Jacqueline M Hogenhout, Huangling Lu, Rianne H A C M de Bruin-Bon, Alexander Hirsch, Peter J Sterk, Berto J Bouma, Bart Straver, Jan G P Tijssen, Barbara J M Mulder, Robbert J de Winter
OBJECTIVE: The association between secundum atrial septal defects (ASD) and asthma-like dyspnea with consequent long-term pulmonary inhalant use, is poorly understood in adult ASD patients. Airway hyperresponsiveness is suggested to be the underlying mechanism of cardiac asthma from mitral valve disease and ischemic cardiomyopathy. We hypothesized that airway hyperresponsiveness may also be found in adult ASD patients. Our aim was to study airway responsiveness in adult ASD patients before percutaneous closure and at short-and long-term postprocedural follow-up...
September 21, 2018: Congenital Heart Disease
Sung-Ai Kim, Min-Kyung Kang, Chi Young Shim, Sak Lee, Byung-Chul Chang, Jong-Won Ha
BACKGROUND: Patients with chronic heart failure have alteration in body composition as a reduction in fat mass, lean body mass and bone mass. However, body wasting in valvular heart disease and the impact of corrective valvular surgery on body composition has not been investigated. OBJECTIVES: We hypothesized that body wasting in severe mitral valve (MV) diseases is reversible through MV surgery. METHODS: Forty eight patients who were scheduled to undergo MV surgery were consecutively enrolled after excluding patients with combined valvular heart disease, ischemic heart disease, cardiomyopathies, and diseases or who were taking medications that could affect metabolism...
2018: PloS One
A Claire Watkins, Nathan L Maassel, Mehrdad Ghoreishi, Murtaza Y Dawood, Si M Pham, Zachary N Kon, Bradley S Taylor, Bartley P Griffith, James S Gammie
BACKGROUND: Cardiac surgery for structural heart disease has poor outcomes in the presence of cardiogenic shock or advanced heart failure. We applied venoarterial extracorporeal membrane oxygenation (ECMO) to restore end-organ function and resuscitate patients before high-risk cardiac operation. METHODS: Twelve patients with cardiogenic shock and end-organ failure were evaluated for cardiac surgery. The average Society of Thoracic Surgeons (STS) mortality risk was 24% (±13)...
September 17, 2018: Annals of Thoracic Surgery
Ravi R Pradhan, Ashish Jha, Gaurav Nepal, Manju Sharma
Valvular heart disease is one of the more common diseases in low- and middle-income countries, when associated with atrial fibrillation (AF), carries a risk of multisystemic embolizations. We report a case of 37-year-old man with multiple systemic emboli consisting of acute ischemic stroke, acute myocardial infarction, and acute limb ischemia. This is a rare occurrence in a single subject. The patient had a background of rheumatic heart disease (RHD) involving severe mitral stenosis (MS) with AF, who was not compliant with his medications...
July 11, 2018: Curēus
Amir H Khalighi, Bruno V Rego, Andrew Drach, Robert C Gorman, Joseph H Gorman, Michael S Sacks
Ischemic mitral regurgitation (IMR) is a currently prevalent disease in the US that is projected to become increasingly common as the aging population grows. In recent years, image-based simulations of mitral valve (MV) function have improved significantly, providing new tools to refine IMR treatment. However, clinical implementation of MV simulations has long been hindered as the in vivo MV chordae tendineae (MVCT) geometry cannot be captured with sufficient fidelity for computational modeling. In the current study, we addressed this challenge by developing a method to produce functionally equivalent MVCT models that can be built from the image-based MV leaflet geometry alone...
September 5, 2018: Annals of Biomedical Engineering
Zhi Qi, Sheng Liu, Fujian Duan
OBJECTIVES: Several trials are investigating the delivery of stem cells to treat ischemic cardiomyopathy. The aim of this study was the echocardiographic evaluation of the effectiveness of isolated coronary artery bypass graft (CABG) combined with bone marrow mononuclear cells (BMMNC) delivered through the graft vessels to improve left ventricular dyssynchrony in patients with previous myocardial infarction and chronic heart failure. METHODS: 42 patients with previous myocardial infarction and chronic heart failure were randomly allocated to either the CABG only group (n = 18) or the CABG with BMMNC graft group (n = 24group)...
August 30, 2018: Journal of Clinical Ultrasound: JCU
Chih-Chung Shiao, Wei-Chih Kan, Jian-Jhong Wang, Yu-Feng Lin, Likwang Chen, Eric Chueh, Ya-Ting Huang, Wen-Po Chiang, Li-Jung Tseng, Chih-Hsien Wang, Vin-Cent Wu
The influence of acute kidney injury (AKI) on subsequent incident atrial fibrillation (AF) has not yet been fully addressed. This retrospective nationwide cohort study was conducted using Taiwan's National Health Insurance Research Database from 1 January 2000 to 31 December 2010. A total of 41,463 patients without a previous AF, mitral valve disease, and hyperthyroidism who developed de novo dialysis-requiring AKI (AKI-D) during their index hospitalization were enrolled. After propensity score matching, "non-recovery group" ( n = 2895), "AKI-recovery group" ( n = 2895) and "non-AKI group" (control group, n = 5790) were categorized...
August 29, 2018: Journal of Clinical Medicine
Koji Furukawa, Mitsuhiro Yano, Eisaku Nakamura, Masanori Nishimura, Kunihide Nakamura
OBJECTIVES: Mitral annuloplasty (MAP) for ischemic mitral regurgitation (IMR) with advanced remodeling is often associated with recurrent mitral regurgitation (MR). We performed surgeries adjusted according to the degree of remodeling; i.e., for advanced remodeling cases, we added subvalvular repair (SVR) to MAP. This study aimed to evaluate our experience with patients with IMR. METHODS AND RESULTS: Thirty patients with IMR (MR grade ≥ 2) were retrospectively analyzed...
August 25, 2018: General Thoracic and Cardiovascular Surgery
Bruno V Rego, Amir H Khalighi, Andrew Drach, Eric K Lai, Alison M Pouch, Robert C Gorman, Joseph H Gorman, Michael S Sacks
Assessment of mitral valve (MV) function is important in many diagnostic, prognostic, and surgical planning applications for treatment of MV disease. Yet, to date, there are no accepted noninvasive methods for determination of MV leaflet deformation, which is a critical metric of MV function. In this study, we present a novel, completely noninvasive computational method to estimate MV leaflet in-plane strains from clinical-quality real-time three-dimensional echocardiography (rt-3DE) images. The images were first segmented to produce meshed medial-surface leaflet geometries of the open and closed states...
August 21, 2018: International Journal for Numerical Methods in Biomedical Engineering
V A Kuznetsov, E I YAroslavskaya, S M Dyachkov
PURPOSE: to identify factors associated with moderate and severe secondary mitral regurgitation (MR) in ischemic heart disease patients without myocardial infarction depending on gender. MATERIALS AND METHODS: From the Register of coronary angiography we selected men and women with significant coronary stenosis (≥75 % of lumen in at least one epicardial artery) who had no acute or previous myocardial infarction: 1001 men without and 66 men with moderate or severe MR, 183 women without and 20 women with moderate or severe MR...
August 2018: Kardiologiia
Yiğit Çanga, Ayşe Emre, Gülbün Asuman Yüksel, Mehmet Baran Karataş, Nizamettin Selçuk Yelgeç, Ufuk Gürkan, Ali Nazmi Çalık, Hülya Tireli, Sait Terzi
Background: An increased risk of ischemic stroke has been reported in patients with Parkinson's disease (PD). Atrial fibrillation (AF) is strongly associated with ischemic stroke. Prolonged atrial electromechanical delay (EMD) is an independent predictor for the development of AF. Aims: The aim of the present study was to evaluate the atrial conduction parameters in patients with PD and to assess their relation with the severity of PD. Study design: We prospectively enrolled 51 consecutive patients with newly diagnosed PD and 31 age- and sex-matched non-PD subjects...
2018: Parkinson's Disease
Ahmet Guner, Alev Kılıcgedik, Macit Kalçık, Mehmet Ozkan
Coronary embolism (CE) is the underlying cause of 3% of acute coronary syndromes but is frequently overlooked in the differential diagnoses of acute coronary syndromes. The CE may be direct (left sided from the native or prosthetic heart valve, the left atrium, left atrial appendage or pulmonary venous bed), paradoxical (from the venous circulation through a patent foramen ovale, atrial septal defect, ventricular septal defects, cyanotic congenital heart defects or pulmonary arteriovenous malformations), or iatrogenic (following cardiac interventions...
August 13, 2018: Echocardiography
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